@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2438c: (2016-05-10 )
MNFYSAYQHGFVRVAACTHHTTIGDPAANAASVLDMARACHDDGAALAVFPELTLSGYSIEDVLLQDSLLDAVEDALLDLVTESADLLPVLVVGAPLRHRHRIYNTAVVIHRGAVLGVVPKSYLPTYREFYERRQMAPGDGERGTIRIGGADVAFGTDLLFAASDLPGFVLHVEICEDMFVPMPPSAEAALAGATVLANLSGSPITIGRAEDRRLLARSASARCLAAYVYAAAGEGESTTDLAWDGQTMIWENGALLAESERFPKGVRRSVADVDTELLRSERLRMGTFDDNRRHHRELTESFRRIDFALDPPAGDIGLLREVERFPFVPADPQRLQQDCYEAYNIQVSGLEQRLRALDYPKVVIGVSGGLDSTHALIVATHAMDREGRPRSDILAFALPGFATGEHTKNNAIKLARALGVTFSEIDIGDTARLMLHTIGHPYSVGEKVYDVTFENVQAGLRTDYLFRIANQRGGIVLGTGDLSELALGWSTYGVGDQMSHYNVNAGVPKTLIQHLIRWVISAGEFGEKVGEVLQSVLDTEITPELIPTGEEELQSSEAKVGPFALQDFSLFQVLRYGFRPSKIAFLAWHAWNDAERGNWPPGFPKSERPSYSLAEIRHWLQIFVQRFYSFSQFKRSALPNGPKVSHGGALSPRGDWRAPSDMSARIWLDQIDREVPKG
Atome Classification :
(20 SA)
-.........10........20.----.......30........40-.........50........60........70........80...-.---.----...90.----------------.......-----------100.......110........120.......130.......140.......150.......160....-...170.......180.....-..190.......200.......210.....--..220.......230.......240.......-250-.......260.......270.......280.......290.......300.......-310.......320.......330-----.......340.......350.......360.......370.......380.....----..390.......400.......410......-.420.......430.......440..-.....450.......460.......470.......480.......490.-......500.......510.......520.......530.......540.....---..550.......560-.......570.......580.......590.......600.......610.......620.......630.......640.......-650.......660.......670.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MN
F
Y
S
A
Y
QHG
F
V
R
V
A
A
CTHHTT----IGDPA
A
N
A
A
S
V
L
D
M
A
R
A
C--HDDG
A
A
L
A
V
FPELTLSGY
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
TES-A---D----
L
L
P
V
L
V
----------------VGAP
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H-R
G
A
V
L
GVV
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
RQMAPGDGER
G
T
I
R
IGGADVAFGT
D
L
L
F
AASDL-P
G
F
V
L
H
V
E
I
C
E
D
MFVPMPPSA-
E
A
A
LAG
A
T
V
L
ANLSGS
P
I
T
IGR
A
E
D
R
R
L
L
A
--
R
SAS
A
R
C
L
A
A
Y
V
Y
AAAGEGESTT
D
L
A
WDG
Q
T
M
-
I
WE-NG
A
L
L
AESERF
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
RLRMGTFDDN
R
R
H
H
R
E
L
T
E
S
F
R
RI
D
F
A
-LDPPA
G
D
I
G
L
L
R
E
V
E
RFPFVPA
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
YNI
Q
V
S
G
L
E
Q
R
L
R
ALDYP
K
V
V
I
G
VSGGLDS
T
H
A
L
I
V
A
T
HAMDRE----GRPRS
D
I
L
A
FALPGFATGEHTKN
N
A
I
K
L
A
R
A
-LG
V
T
F
S
EIDIG
D
T
A
R
L
M
L
H
TIGHPYS-VG
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
ANQRG
G
I
V
L
GTG
D
L
S
E
L
A
LGWSTY-GVGDQMSHYNVNAG
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
LDTEITPELI---PT
G
E
E
E
L
Q
SSEAKVG-P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
YGFRP
S
K
I
A
F
L
A
W
H
AWNDAERGNWPPGFPKSERPSY
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
ALPNGPKVSHGG-ALSPRGDWRAPSDM
S
A
R
I
W
L
D
Q
I
D
R
EVPKG
21
PsiBlast_CBE
99.31
100%
-111
- C2 -
3SYT
5
NADE_MYCTU
B:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
F
------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
P
Y
S
-
V
G
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
25
PsiBlast_CBE
98.94
99%
-112
- C2 -
3SEZ
3
NADE_MYCTU
B:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
F
------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
P
Y
S
-
V
G
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
-------------------
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
22
PsiBlast_CBE
98.53
100%
-112
- C2 -
3DLA
9
NADE_MYCTU
B:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
-------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
-----------
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
2
PsiBlast_PDB
98.44
100%
-111
- C2 -
3SYT
6
NADE_MYCTU
A:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
F
------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
P
Y
S
-
V
G
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
24
PsiBlast_CBE
98.19
99%
-112
- C2 -
3SZG
5
NADE_MYCTU
B:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
-------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
----------
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
-----------------
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
23
PsiBlast_CBE
98.18
99%
-112
- C2 -
3SZG
6
NADE_MYCTU
D:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
F
------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
P
Y
S
-
V
G
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
------------------
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
4
PsiBlast_PDB
97.96
99%
-112
- C2 -
3SEQ
3
NADE_MYCTU
A:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
F
------
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
P
Y
S
-
V
G
E
K
V
Y
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
26
HHSearch
97.21
99%
-112
- C2 -
3SDB
-
NADE_MYCTU
A:
[1-679]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
-
P
S
A
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
--------
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
-------------
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
G
V
-
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
-
H
G
G
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
47
Fugue
97.13
99%
-113
- C2 -
3DLA
7
NADE_MYCTU
A:
[1-680]
S
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
-----
H
T
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
----------
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
A
K
V
------------------
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
3
PsiBlast_PDB
96.94
99%
-111
- C2 -
3SDB
-
NADE_MYCTU
A:
[1-679]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
A
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
--------
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
-------------
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
----------------
S
E
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
1
PsiBlast_PDB
96.80
100%
-113
- C2 -
3DLA
7
NADE_MYCTU
A:
[2-680]
-
M
N
F
Y
S
A
Y
Q
H
G
F
V
R
V
A
A
C
T
H
H
T
T
----
I
G
D
P
A
A
N
A
A
S
V
L
D
M
A
R
A
C
--
H
D
D
G
A
A
L
A
V
F
P
E
L
T
L
S
G
Y
S
I
E
D
V
L
L
Q
D
S
L
L
D
A
V
E
D
A
L
L
D
L
V
T
E
S
-
A
---
D
----
L
L
P
V
L
V
----------------
V
G
A
P
L
R
H
-----------
R
H
R
I
Y
N
T
A
V
V
I
H
-
R
G
A
V
L
G
V
V
P
K
S
Y
L
P
T
Y
R
E
F
Y
E
R
R
Q
M
A
P
G
D
G
E
R
G
T
I
R
I
G
G
A
D
V
A
F
G
T
D
L
L
F
A
A
S
D
L
-
P
G
F
V
L
H
V
E
I
C
E
D
M
F
V
P
M
P
P
S
A
-
E
A
A
L
A
G
A
T
V
L
A
N
L
S
G
S
P
I
T
I
G
R
A
E
D
R
R
L
L
A
--
R
S
A
S
A
R
C
L
A
A
Y
V
Y
A
A
A
G
E
G
E
S
T
T
D
L
A
W
D
G
Q
T
M
-
I
W
E
-
N
G
A
L
L
A
E
S
E
R
F
P
K
G
V
R
R
S
V
A
D
V
D
T
E
L
L
R
S
E
R
L
R
M
G
T
F
D
D
N
R
R
H
H
R
E
L
T
E
S
F
R
R
I
D
F
A
-
L
D
P
P
A
G
D
I
G
L
L
R
E
V
E
R
F
P
F
V
P
A
D
-----
P
Q
R
L
Q
Q
D
C
Y
E
A
Y
N
I
Q
V
S
G
L
E
Q
R
L
R
A
L
D
Y
P
K
V
V
I
G
V
S
G
G
L
D
S
T
H
A
L
I
V
A
T
H
A
M
D
R
E
----
G
R
P
R
S
D
I
L
A
F
A
L
P
G
-----
H
T
K
N
N
A
I
K
L
A
R
A
-
L
G
V
T
F
S
E
I
D
I
G
D
T
A
R
L
M
L
H
T
I
G
H
----------
D
V
T
F
E
N
V
Q
A
G
L
R
T
D
Y
L
F
R
I
A
N
Q
R
G
G
I
V
L
G
T
G
D
L
S
E
L
A
L
G
W
S
T
Y
-
G
V
G
D
Q
M
S
H
Y
N
V
N
A
G
V
P
K
T
L
I
Q
H
L
I
R
W
V
I
S
A
G
E
F
G
E
K
V
G
E
V
L
Q
S
V
L
D
T
E
I
T
------------------
A
K
V
G
-
P
F
A
L
Q
D
F
S
L
F
Q
V
L
R
Y
G
F
R
P
S
K
I
A
F
L
A
W
H
A
W
N
D
A
E
R
G
N
W
P
P
G
F
P
K
S
E
R
P
S
Y
S
L
A
E
I
R
H
W
L
Q
I
F
V
Q
R
F
Y
S
F
S
Q
F
K
R
S
A
L
P
N
G
P
K
V
S
H
G
G
-
A
L
S
P
R
G
D
W
R
A
P
S
D
M
S
A
R
I
W
L
D
Q
I
D
R
E
V
P
K
G
29
HHSearch
52.53
29%
-86
- C2 -
4F4H
2
?
A:
[6-565]
-----------
K
T
R
I
A
L
A
Q
L
N
V
T
----
V
G
D
F
A
G
N
V
A
K
I
V
A
A
A
Q
A
A
--
H
D
A
G
A
H
F
L
I
A
P
E
L
A
L
S
G
Y
P
P
E
D
L
L
L
R
P
A
F
Y
A
A
S
D
A
A
L
A
E
L
A
A
Q
L
K
P
---
F
----
A
G
L
A
V
L
----------------
V
G
H
P
L
R
A
PANRAIERGVP
P
V
D
T
Y
N
A
A
S
L
I
V
-
G
G
E
V
A
G
T
Y
R
K
Q
D
L
P
N
T
E
V
F
D
E
K
R
Y
F
A
T
D
A
A
P
----------------
Y
V
F
E
---
L
-
N
G
V
K
F
G
V
V
I
C
E
D
V
W
H
A
S
A
-
A
Q
-
L
A
K
A
A
G
A
Q
V
L
I
V
P
N
G
S
P
Y
H
M
N
K
D
A
V
R
I
D
I
L
--
R
A
R
I
R
E
T
G
L
P
M
V
Y
V
N
L
V
G
G
Q
--
D
E
L
V
F
D
G
G
S
F
V
L
D
G
-
A
G
E
L
V
A
K
M
P
Q
F
E
--
E
G
N
A
I
V
E
F
D
G
A
R
A
L
P
A
----------------------------------------------
A
I
A
P
---------
A
L
S
V
E
A
Q
V
Y
R
A
L
V
L
G
V
R
D
Y
I
G
K
N
G
F
P
G
A
I
I
G
L
S
G
G
V
D
S
A
L
V
L
A
V
A
V
D
A
L
G
A
---------
E
R
V
R
A
V
M
M
P
S
R
Y
T
A
G
I
S
T
T
D
A
A
D
M
A
R
R
-
V
G
V
R
Y
D
E
I
A
I
A
P
M
F
D
A
F
R
A
S
L
A
A
E
F
---
A
G
L
A
E
D
A
T
E
E
N
I
Q
A
R
I
R
G
T
L
L
M
A
L
S
N
K
F
G
S
I
V
L
T
T
G
N
K
S
E
M
A
V
G
Y
C
T
L
-
Y
-
G
D
M
A
G
G
F
A
V
I
K
D
I
A
K
T
L
V
Y
R
L
C
R
Y
R
N
A
A
A
E
Y
-
G
Q
P
D
I
V
P
E
R
I
L
T
R
-----------------------
L
P
-
P
Y
D
V
L
D
A
I
M
R
M
Y
M
E
E
D
R
P
L
A
E
I
V
A
A
---
G
--------------------
Y
S
----
E
A
D
V
K
R
V
T
R
L
I
K
-
I
N
E
Y
K
R
R
Q
A
P
V
G
I
R
V
T
-
H
R
-
A
F
G
-
R
-
D
W
R
Y
P
I
T
S
R
---
F
V
E
S
I
D
------
28
HHSearch
52.46
28%
-90
* C2 *
3N05
3
?
A:
[2-583]
---------
S
L
Q
L
R
L
A
L
N
Q
I
D
S
T
----
V
G
D
I
A
G
N
A
E
A
I
L
R
W
T
R
H
S
--
A
E
Q
G
A
H
L
V
A
F
P
E
M
A
L
T
G
Y
P
V
E
D
L
A
L
R
S
S
F
V
E
A
S
R
T
A
L
R
E
L
A
A
R
L
-
A
E
E
G
F
----
G
E
L
P
V
L
----------------
V
G
Y
L
D
R
S
ESAQPKYGQP-
A
G
A
P
R
N
A
A
A
V
L
H
-
R
G
R
V
A
L
T
F
A
K
H
H
L
P
N
Y
G
V
F
D
E
F
R
Y
F
V
P
G
D
T
M
----------------
P
I
V
R
---
L
-
H
G
V
D
I
A
L
A
I
C
E
D
L
W
Q
D
G
G
R
V
P
-
A
A
R
S
A
G
A
G
L
L
L
S
V
N
A
S
P
Y
E
R
D
K
D
D
T
R
L
E
L
V
--
R
K
R
A
Q
E
A
G
C
T
T
A
Y
L
A
M
I
G
G
Q
--
D
E
L
V
F
D
G
D
S
I
V
V
D
R
-
D
G
E
V
V
A
R
A
P
Q
F
S
--
E
G
C
V
V
L
D
L
D
L
P
A
A
E
A
E
P
P
T
-
G
V
V
D
D
G
-----------
L
R
I
D
R
L
V
I
S
E
-
E
P
L
P
A
Y
E
--
A
E
L
A
G
G
Y
A
D
---------
R
L
D
A
D
E
E
V
Y
S
A
L
V
V
G
L
R
A
Y
V
A
K
N
G
F
R
S
V
L
I
G
L
S
G
G
I
D
S
A
L
V
A
A
I
A
C
D
A
L
G
A
---------
Q
N
V
Y
G
V
S
M
P
S
K
Y
S
S
D
H
S
K
G
D
A
A
E
L
A
R
R
-
T
G
L
N
F
R
T
V
S
I
E
P
M
F
D
A
Y
M
A
S
L
G
---------
L
T
G
L
A
E
E
N
L
Q
S
R
L
R
G
T
T
L
M
A
I
S
N
Q
E
G
H
I
V
L
A
P
G
N
K
S
E
L
A
V
G
Y
S
T
L
-
Y
-
G
D
S
V
G
A
Y
G
P
I
K
D
V
Y
K
T
S
I
F
R
L
A
E
W
R
N
R
A
A
A
E
R
G
Q
T
P
P
I
P
E
A
S
I
T
K
P
-------------------------
D
Y
P
V
L
D
A
I
L
E
L
Y
V
D
R
D
T
G
A
D
A
I
V
A
A
---
G
--------------------
Y
D
R
----
E
L
V
V
K
T
L
R
M
V
D
-
T
A
E
Y
K
R
R
Q
Y
P
P
G
T
K
I
S
-
A
K
-
G
F
G
-
K
-
D
R
R
L
P
I
T
N
R
---
W
R
E
---------
5
PsiBlast_PDB
50.36
29%
-91
- C2 -
3N05
3
?
A:
[5-487]
------------
L
R
L
A
L
N
Q
I
D
S
T
----
V
G
D
I
A
G
N
A
E
A
I
L
R
W
T
R
H
S
--
A
E
Q
G
A
H
L
V
A
F
P
E
M
A
L
T
G
Y
P
V
E
D
L
A
L
R
S
S
F
V
E
A
S
R
T
A
L
R
E
L
A
A
R
L
-
A
---
E
E
GFG
E
L
P
V
L
V
G
Y
L
D
R
S
ESAQPKYGQP
A
G
A
P
------------------
R
N
A
A
A
V
L
H
-
R
G
R
V
A
L
T
F
A
K
H
H
L
P
N
Y
G
V
F
D
E
F
R
Y
F
V
P
G
D
-
T
M
P
I
V
R
L
H
G
V
D
I
A
L
A
-------------------
I
C
E
D
L
W
Q
D
G
G
R
V
P
-
A
A
R
S
A
G
A
G
L
L
L
S
V
N
A
S
P
Y
E
R
D
K
D
D
T
R
L
E
L
V
R
K
R
A
Q
E
A
G
C
T
T
A
Y
L
A
M
I
G
G
Q
D
E
----
L
V
F
D
G
D
S
I
-
V
V
D
R
D
G
E
V
V
A
R
A
P
Q
F
S
E
G
C
--
V
V
L
D
L
D
L
P
A
A
E
A
E
P
-
P
T
G
V
V
D
D
G
L
R
I
D
R
----------------------
L
V
I
S
E
E
P
L
P
A
Y
E
A
E
LAGGY
A
D
R
L
D
A
D
-
E
E
V
Y
S
A
L
V
V
G
L
R
A
Y
V
A
K
N
G
F
R
S
V
L
I
G
L
S
G
G
I
D
S
A
L
V
A
A
I
A
C
D
A
L
G
A
Q
---------
N
V
Y
G
V
S
M
P
S
K
Y
S
S
D
H
S
K
G
D
A
A
E
L
A
R
R
-
T
G
L
N
F
R
T
V
S
I
E
P
M
F
D
A
Y
M
A
S
L
G
---------
L
T
G
L
A
E
E
N
L
Q
S
R
L
R
G
T
T
L
M
A
I
S
N
Q
E
G
H
I
V
L
A
P
G
N
K
S
E
L
A
V
G
Y
S
T
L
--
Y
G
D
S
V
G
A
Y
G
P
I
K
D
V
Y
K
T
S
I
F
R
L
A
E
W
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
40.33
21%
-94
- C2 -
3P52
1
NADE_CAMJE
A:
[5-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
Q
K
I
T
E
K
M
C
D
F
I
Q
E
K
V
K
N
S
Q
S
Q
G
V
V
L
G
L
S
G
G
I
D
S
A
L
V
A
T
L
C
K
R
A
L
K
----------
E
N
V
F
A
L
L
M
P
T
Q
I
S
N
K
A
N
L
E
D
A
L
R
L
C
A
D
-
L
N
L
E
Y
K
I
I
E
I
Q
S
I
L
D
A
F
I
K
Q
S
E
--------
N
T
T
L
V
S
L
G
N
F
A
A
R
I
R
M
S
L
L
Y
D
Y
S
A
L
K
N
S
L
V
I
G
T
S
N
K
S
E
L
L
L
G
Y
G
T
I
-
Y
-
G
D
L
A
C
A
F
N
P
I
G
S
L
Y
K
S
E
I
Y
A
L
A
K
Y
L
N
-----------
L
H
E
N
F
I
K
K
-------------------------F
S
Y
T
K
I
D
E
G
L
K
A
L
E
T
N
D
E
---
K
L
L
R
----
T
--------------------
L
D
----
P
S
L
I
A
M
L
K
N
R
M
Q
-
K
N
A
F
K
G
K
-
M
P
E
I
L
E
------------------------------------
43
HHSearch
37.12
22%
-90
- C2 -
2DYU
-
AMIF_HELPY
A:
[13-274]
-----------
G
F
L
V
A
A
I
Q
F
P
V
P
IVNS
R
K
D
I
D
H
N
I
E
S
I
I
R
T
L
H
A
T
K
A
G
Y
P
G
V
E
L
I
I
F
P
E
Y
S
T
Q
G
L
N
T
A
K
W
L
S
E
E
F
L
L
D
V
P
G
K
E
T
E
L
Y
A
K
A
C
-
K
---
E
----
A
K
V
Y
G
V
----------------
F
S
I
M
E
R
N
PDS--------
N
K
N
P
Y
N
T
A
I
I
I
D
P
Q
G
E
I
I
L
K
Y
R
K
L
F
P
W
N
P
----
I
-
E
P
W
Y
P
G
D
L
G
----------
M
-----
P
V
C
E
---
G
P
G
G
S
K
L
A
V
C
I
C
H
D
G
M
I
P
E
L
-
A
R
-
E
A
A
Y
K
G
C
N
V
Y
I
R
I
S
G
Y
S
T
Q
V
--
N
D
Q
W
I
L
T
N
--
R
S
N
A
W
H
N
L
M
Y
T
V
S
V
N
L
A
G
Y
D
--
N
V
F
Y
Y
F
G
E
G
Q
I
C
N
F
-
D
G
T
T
L
V
Q
G
H
R
N
--
P
W
E
I
V
T
G
E
I
Y
P
K
M
A
D
N
A
R
L
S
W
G
L
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
35.18
21%
-83
- C2 -
3P52
1
NADE_CAMJE
A:
[17-189]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
Q
E
K
V
K
N
S
Q
S
Q
G
V
V
L
G
L
S
G
G
I
D
S
A
L
V
A
T
L
C
K
R
A
L
----------
K
E
N
V
F
A
L
L
M
P
T
Q
I
S
N
K
A
N
L
E
D
A
L
R
L
C
A
D
-
L
N
L
E
Y
K
I
I
E
I
Q
S
I
L
D
A
F
I
K
Q
--------
S
E
N
T
T
L
V
S
L
G
N
F
A
A
R
I
R
M
S
L
L
Y
D
Y
S
A
L
K
N
S
L
V
I
G
T
S
N
K
S
E
L
L
L
G
Y
G
T
I
--
Y
G
D
L
A
C
A
F
N
P
I
G
S
L
Y
K
S
E
I
Y
A
L
A
K
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
34.82
26%
-80
- C2 -
4F4H
2
?
A:
[282-555]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
Y
R
A
L
V
L
G
V
R
D
Y
I
G
K
N
G
F
P
G
A
I
I
G
L
S
G
G
V
D
S
A
L
V
L
A
V
A
V
D
A
L
G
A
E
---------
R
V
R
A
V
M
M
P
S
R
Y
T
A
G
I
S
T
T
D
A
A
D
M
A
R
R
-
V
G
V
R
Y
D
E
I
A
I
A
P
M
F
D
A
F
R
A
S
L
A
A
E
F
A
G
L
A
E
---
D
A
T
E
E
N
I
Q
A
R
I
R
G
T
L
L
M
A
L
S
N
K
F
G
S
I
V
L
T
T
G
N
K
S
E
M
A
V
G
Y
C
T
L
--
Y
G
D
M
A
G
G
F
A
V
I
K
D
I
A
K
T
L
V
Y
R
L
C
R
Y
R
N
A
A
A
E
Y
G
Q
P
-----------
D
I
V
P
E
R
I
L
T
R-------------
L
P
-
P
Y
D
V
L
D
-
A
I
M
R
M
Y
M
E
E
D
R
P
L
A
E
I
V
A
A
G
Y
S
E
A
D
V
K
R
---------------------------
V
T
R
L
I
K
I
N
E
Y
K
R
R
Q
A
P
V
G
I
R
V
T
H
R
A
-
F
G
R
---
D
W
R
Y
P
-------------------
33
HHSearch
34.42
22%
-78
- C2 -
5F23
2
NADE_PSEAE
A:
[31-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Q
A
Q
I
A
R
R
I
A
F
I
Q
Q
C
L
K
D
S
G
L
K
T
L
V
L
G
I
S
G
G
V
D
S
L
T
A
G
L
L
A
Q
R
A
V
E
Q
L
R
E
Q
T
G
D
Q
A
Y
R
F
I
A
V
R
L
P
Y
Q
V
Q
--
Q
D
E
A
D
A
Q
A
S
L
A
T
I
R
A
D
E
E
Q
T
V
N
I
G
P
S
V
K
A
L
A
E
Q
L
E
A
L
E
G
-
L
E
P
A
K
S
D
F
V
I
G
N
I
K
A
R
I
R
M
V
A
Q
Y
A
I
A
G
A
R
G
G
L
V
I
G
T
D
H
A
A
E
A
V
M
G
F
F
T
K
-
F
-
G
D
G
A
C
D
L
A
P
L
S
G
L
A
K
H
Q
V
R
A
L
A
R
A
L
G
-----------
A
P
E
N
L
V
E
K
I
----------------------
H
G
V
T
Y
A
E
I
D
A
F
L
H
G
Q
P
L
------------------------------------
R
----
E
E
A
A
R
V
I
V
D
T
Y
H
-
K
T
Q
H
K
R
E
-
L
P
K
A
--------------------------------------
32
HHSearch
34.05
24%
-79
- C2 -
2E18
7
NADE_PYRHO
A:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
I
E
R
I
L
E
F
I
R
E
K
G
N
N
G
V
V
I
G
I
S
G
G
V
D
S
A
T
V
A
Y
L
A
T
K
A
L
G
K
---------
E
K
V
L
G
L
I
M
P
Y
F
--
E
N
K
D
V
E
D
A
K
L
V
A
E
K
-
L
G
I
G
Y
K
V
I
N
I
K
P
I
V
D
S
F
V
E
N
L
E
L
N
-------
L
D
R
K
G
L
G
N
I
M
S
R
T
R
M
I
M
L
Y
A
H
A
N
S
L
G
R
I
V
L
G
T
S
N
R
S
E
F
L
T
G
Y
F
T
K
-
W
-
G
D
G
A
S
D
Y
A
P
I
I
N
L
Y
K
T
E
V
W
E
I
A
K
R
I
G
-----------
V
P
E
R
I
V
K
K
K
P
S
A
G
L
W
---
E
G
-----
Q
T
D
E
D
E
L
G
I
S
Y
N
L
L
D
E
I
L
W
R
M
I
D
L
K
I
G
K
E
E
I
A
K
D
L
--
G
--------------------
I
P
----
L
S
L
V
E
R
V
E
E
L
I
K
-
K
S
E
H
K
R
R
-
L
P
I
G
P
S
F
E
-
D
L
-------------------------------