@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv2579: (2016-05-12 )
MTAFGVEPYGQPKYLEIAGKRMAYIDEGKGDAIVFQHGNPTSSYLWRNIMPHLEGLGRLVACDLIGMGASDKLSPSGPDRYSYGEQRDFLFALWDALDLGDHVVLVLHDWGSALGFDWANQHRDRVQGIAFMEAIVTPMTWADWPPAVRGVFQGFRSPQGEPMALEHNIFVERVLPGAILRQLSDEEMNHYRRPFVNGGEDRRPTLSWPRNLPIDGEPAEVVALVNEYRSWLEETDMPKLFINAEPGAIITGRIRDYVRSWPNQTEITVPGVHFVQEDSPEEIGAAIAQFVRRLRSAAGV
Atome Classification :
(28 SA)
.........10........20.......--.30-.........40........50........60........70........-80........90........100.......110.......120.......130....-...-140.......150.......-160.......170.......180.......190.......200.......210.-......220.......230...-....240.......250........260.......-270.......280.......290.......300
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTAFGVEPYGQPK
Y
L
EIAG
K
R
M
A
Y
I
DEG--KG--
D
A
I
V
F
QHGNP
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
R
L
V
A
C
D
L
IGMGASDKLSPSGPD-RYSYGE
Q
R
D
F
L
F
A
L
W
D
A
LDLGD
H
V
V
L
V
L
HDWGSALGFD
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
I
V-TPM-TWADW
P
P
A
V
R
G
V
F
Q
G
F
RSPQ-GE
P
M
A
LEH
N
I
F
V
E
RVL
P
G
A
I
L
R
Q
L
S
D
E
E
M
N
H
Y
RRPFVNGGEDRRPTLSWPRNLP-IDG
E
P
A
E
V
V
A
L
V
N
E
Y
R
S
W
L
E
ET-DM
P
K
L
F
I
NAEPG
A
I
I
-
T
G
R
I
R
D
Y
V
R
SWPNQ
T
E
I
T
V-P
G
V
H
FVQED
S
P
E
E
I
G
A
A
I
A
Q
F
V
R
R
L
R
S
AAGV
1
PsiBlast_PDB
96.79
100%
-115
- C1 -
2O2H
3
DHAA_MYCTU
A:
[4-297]
---
F
G
V
E
P
Y
G
Q
P
K
Y
L
E
I
A
G
K
R
M
A
Y
I
D
E
G
--
K
G
--
D
A
I
V
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
R
L
V
A
C
D
L
I
G
M
G
A
S
D
K
L
S
P
S
G
P
D
-
R
Y
S
Y
G
E
Q
R
D
F
L
F
A
L
W
D
A
L
D
L
G
D
H
V
V
L
V
L
H
D
W
G
S
A
L
G
F
D
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
I
V
-
T
P
M
-
T
W
A
D
W
P
P
A
V
R
G
V
F
Q
G
F
R
S
P
Q
-
G
E
P
M
A
L
E
H
N
I
F
V
E
R
V
L
P
G
A
I
L
R
Q
L
S
D
E
E
M
N
H
Y
R
R
P
F
V
N
G
G
E
D
R
R
P
T
L
S
W
P
R
N
L
P
-
I
D
G
E
P
A
E
V
V
A
L
V
N
E
Y
R
S
W
L
E
E
T
-
D
M
P
K
L
F
I
N
A
E
P
G
A
I
I
-
T
G
R
I
R
D
Y
V
R
S
W
P
N
Q
T
E
I
T
V
-
P
G
V
H
F
V
Q
E
D
S
P
E
E
I
G
A
A
I
A
Q
F
V
R
R
L
R
S
A
---
21
PsiBlast_CBE
96.47
100%
-115
- C1 -
2QVB
2
DHAA_MYCTU
B:
[1-297]
--
A
F
G
V
E
P
Y
G
Q
P
K
Y
L
E
I
A
G
K
R
M
A
Y
I
D
E
G
--
K
G
--
D
A
I
V
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
R
L
V
A
C
D
L
I
G
M
G
A
S
D
K
L
S
P
S
G
P
D
-
R
Y
S
Y
G
E
Q
R
D
F
L
F
A
L
W
D
A
L
D
L
G
D
H
V
V
L
V
L
H
D
W
G
S
A
L
G
F
D
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
I
V
-
T
P
M
-
T
W
A
D
W
P
P
A
V
R
G
V
F
Q
G
F
R
S
P
Q
-
G
E
P
M
A
L
E
H
N
I
F
V
E
R
V
L
P
G
A
I
L
R
Q
L
S
D
E
E
M
N
H
Y
R
R
P
F
V
N
G
G
E
D
R
R
P
T
L
S
W
P
R
N
L
P
-
I
D
G
E
P
A
E
V
V
A
L
V
N
E
Y
R
S
W
L
E
E
T
-
D
M
P
K
L
F
I
N
A
E
P
G
A
I
I
-
T
G
R
I
R
D
Y
V
R
S
W
P
N
Q
T
E
I
T
V
-
P
G
V
H
F
V
Q
E
D
S
P
E
E
I
G
A
A
I
A
Q
F
V
R
R
L
R
S
A
A
G
-
2
PsiBlast_PDB
95.99
100%
-118
- C1 -
2O2I
2
DHAA_MYCTU
A:
[4-296]
---
F
G
V
E
P
Y
G
Q
P
K
Y
L
E
I
A
G
K
R
M
A
Y
I
D
E
G
--
K
G
--
D
A
I
V
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
R
L
V
A
C
D
L
I
G
M
G
A
S
D
K
L
S
P
S
G
P
D
-
R
Y
S
Y
G
E
Q
R
D
F
L
F
A
L
W
D
A
L
D
L
G
D
H
V
V
L
V
L
H
D
W
G
S
A
L
G
F
D
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
I
V
-
T
P
M
-
T
W
A
D
W
P
P
A
V
R
G
V
F
Q
G
F
R
S
P
Q
-
G
E
P
M
A
L
E
H
N
I
F
V
E
R
V
L
P
G
A
I
L
R
Q
L
S
D
E
E
M
N
H
Y
R
R
P
F
V
N
G
G
E
D
R
R
P
T
L
S
W
P
R
N
L
P
-
I
D
G
E
P
A
E
V
V
A
L
V
N
E
Y
R
S
W
L
E
E
T
-
D
M
P
K
L
F
I
N
A
E
P
G
A
I
I
-
T
G
R
I
R
D
Y
V
R
S
W
P
N
Q
T
E
I
T
V
-
P
G
V
H
F
V
Q
E
D
S
P
E
E
I
G
A
A
I
A
Q
F
V
R
R
L
R
S
----
6
PsiBlast_PDB
87.63
69%
-113
- C1 -
2BFN
4
LINB_SPHPI
A:
[3-296]
---
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
7
PsiBlast_PDB
87.37
69%
-110
- C1 -
1MJ5
3
LINB_SPHPI
A:
[2-296]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
10
PsiBlast_PDB
87.36
69%
-111
- C1 -
1K5P
2
LINB_SPHPI
A:
[1-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
15
PsiBlast_PDB
87.14
69%
-111
- C1 -
4WDQ
2
LINB_SPHPI
A:
[1-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
W
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
8
PsiBlast_PDB
86.80
69%
-113
- C1 -
1IZ7
3
LINB_SPHPI
A:
[2-295]
---
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
11
PsiBlast_PDB
86.74
69%
-109
- C1 -
1K63
4
LINB_SPHPI
A:
[1-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
16
PsiBlast_PDB
86.59
69%
-110
- C1 -
4H7F
6
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
V
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
T
-
M
P
L
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
H
L
T
-
T
G
R
I
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
12
PsiBlast_PDB
86.54
69%
-109
- C1 -
1K6E
4
LINB_SPHPI
A:
[1-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
17
PsiBlast_PDB
86.40
68%
-110
- C1 -
4H77
5
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
V
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
V
T
-
M
P
L
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
H
L
T
-
T
G
R
I
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
14
PsiBlast_PDB
86.38
69%
-111
- C1 -
4H7E
4
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
V
T
-
M
P
L
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
H
L
T
-
T
G
R
I
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
4
PsiBlast_PDB
86.32
69%
-113
- C1 -
1CV2
-
LINB_SPHPI
A:
[4-296]
----
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
23
PsiBlast_CBE
86.21
69%
-110
- C1 -
4WDR
2
?
A:
[1-293]
----
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
A
A
D
L
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
W
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
L
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
5
PsiBlast_PDB
86.12
69%
-112
- C1 -
1D07
3
LINB_SPHPI
A:
[4-296]
----
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
19
PsiBlast_PDB
86.08
68%
-112
- C1 -
4H7I
4
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
V
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
V
T
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
H
L
T
-
T
G
R
I
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
3
PsiBlast_PDB
86.01
100%
-124
- C- -
2QVB
2
DHAA_MYCTU
A:
[1-297]
--
A
F
G
V
E
P
Y
G
Q
P
K
Y
L
E
I
A
G
K
R
M
A
Y
I
D
E
G
--
K
G
--
D
A
I
V
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
L
E
G
L
G
R
L
V
A
C
D
L
I
G
M
G
A
S
D
K
L
S
P
S
G
P
D
-
R
Y
S
Y
G
E
Q
R
D
F
L
F
A
L
W
D
A
L
D
L
G
D
H
V
V
L
V
L
H
D
W
G
S
A
L
G
F
D
W
A
N
Q
H
R
D
R
V
Q
G
I
A
F
M
E
A
I
V
-
T
P
M
-
T
W
A
D
W
P
P
A
V
R
G
V
F
Q
G
F
R
S
P
Q
-
G
E
P
M
A
L
E
H
N
I
F
V
E
R
V
L
P
G
A
I
L
R
Q
L
S
D
E
E
M
N
H
Y
R
R
P
F
V
N
G
G
E
D
R
R
P
T
L
S
W
P
R
N
L
P
-
I
D
G
E
P
A
E
V
V
A
L
V
N
E
Y
R
S
W
L
E
E
T
-
D
M
P
K
L
F
I
N
A
E
P
G
A
I
I
-
T
G
R
I
R
D
Y
V
R
S
W
P
N
Q
T
E
I
T
V
-
P
G
V
H
F
V
Q
E
D
S
P
E
E
I
G
A
A
I
A
Q
F
V
R
R
L
R
S
A
A
G
-
9
PsiBlast_PDB
85.96
69%
-111
- C1 -
1IZ8
5
LINB_SPHPI
A:
[2-295]
---
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
A
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
A
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
I
A
-
M
P
I
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
A
---
22
PsiBlast_CBE
85.83
68%
-111
- C1 -
4H7K
2
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
V
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
V
T
-
M
P
L
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
H
L
T
-
T
G
R
M
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
13
PsiBlast_PDB
85.73
69%
-109
- C1 -
4H7J
4
?
A:
[2-295]
--
S
L
G
A
K
P
F
G
E
K
K
F
I
E
I
K
G
R
R
M
A
Y
I
D
E
G
--
T
G
--
D
P
I
L
F
Q
H
G
N
P
T
S
S
Y
L
W
R
N
I
M
P
H
C
A
G
L
G
R
L
I
A
C
D
L
I
G
M
G
D
S
D
K
L
D
P
S
G
P
E
-
R
Y
T
Y
A
E
H
R
D
Y
L
D
A
L
W
E
A
L
D
L
G
D
R
V
V
L
V
V
H
D
W
G
S
V
L
G
F
D
W
A
R
R
H
R
E
R
V
Q
G
I
A
Y
M
E
A
V
T
-
M
P
L
-
E
W
A
D
F
P
E
Q
D
R
D
L
F
Q
A
F
R
S
Q
A
-
G
E
E
L
V
L
Q
D
N
V
F
V
E
Q
V
L
P
G
L
I
L
R
P
L
S
E
A
E
M
A
A
Y
R
E
P
F
L
A
A
G
E
A
R
R
P
T
L
S
W
P
R
Q
I
P
-
I
A
G
T
P
A
D
V
V
A
I
A
R
D
Y
A
G
W
L
S
E
S
-
P
I
P
K
L
F
I
N
A
E
P
G
A
L
T
-
T
G
R
I
R
D
F
C
R
T
W
P
N
Q
T
E
I
T
V
-
A
G
A
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
I
A
A
F
V
R
R
L
R
P
----
35
PsiBlast_CBE
78.28
45%
-107
- C1 -
4FWB
5
DHAA_RHORH
A:
[9-291]
-----------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
--
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
-----
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
-
P
F
P
-
T
W
D
E
W
P
E
F
A
R
E
T
F
Q
A
F
R
T
A
D
V
G
R
E
L
I
I
D
Q
N
A
F
I
E
G
A
L
P
K
Y
V
V
R
P
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
-
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
-
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
S
-
P
V
P
K
L
L
F
W
G
T
P
G
F
I
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
F
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
H
-----
31
PsiBlast_CBE
77.13
45%
-106
- C1 -
4F5Z
2
DHAA_RHORH
A:
[12-293]
-----------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
--
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
-----
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
V
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
-
P
I
P
-
T
W
D
E
W
P
E
F
A
R
E
T
F
Q
A
F
R
T
A
D
V
G
R
E
L
I
I
D
Q
N
A
F
I
E
G
V
L
P
K
C
V
V
R
P
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
-
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
-
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
S
-
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
------
37
PsiBlast_CBE
77.10
45%
-109
- C1 -
3FBW
8
?
A:
[12-293]
-----------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
--
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
-----
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
-
P
I
P
-
T
W
D
E
W
P
E
F
A
R
E
T
F
Q
A
F
R
T
A
D
V
G
R
E
L
I
I
D
Q
N
A
F
I
E
G
A
L
P
K
Y
V
V
R
P
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
-
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
-
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
S
-
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
------
36
PsiBlast_CBE
77.01
45%
-106
- C1 -
3G9X
3
DHAA_RHOSO
A:
[12-293]
-----------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
--
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
-----
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
-
P
F
P
-
T
W
D
E
W
P
E
F
A
R
E
T
F
Q
A
F
R
T
A
D
V
G
R
E
L
I
I
D
Q
N
A
F
I
E
G
A
L
P
K
C
V
V
R
P
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
-
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
-
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
S
-
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
------
38
PsiBlast_CBE
76.63
45%
-107
- C1 -
3FWH
4
DHAA_RHOSO
A:
[12-293]
-----------
P
H
Y
V
E
V
L
G
E
R
M
H
Y
V
D
V
G
P
R
D
G
--
T
P
V
L
F
L
H
G
N
P
T
S
S
Y
L
W
R
N
I
I
P
H
V
A
P
S
H
R
C
I
A
P
D
L
I
G
M
G
K
S
D
K
-----
P
D
L
D
Y
F
F
D
D
H
V
R
Y
L
D
A
F
I
E
A
L
G
L
-
E
E
V
V
L
V
I
H
D
W
G
S
A
L
G
F
H
W
A
K
R
N
P
E
R
V
K
G
I
A
C
M
E
F
I
R
-
P
F
P
-
T
W
D
E
W
P
E
F
A
R
E
T
F
Q
A
F
R
T
A
D
V
G
R
E
L
I
I
D
Q
N
A
F
I
E
G
A
L
P
K
Y
V
V
R
P
L
T
E
V
E
M
D
H
Y
R
E
P
F
L
K
-
P
V
D
R
E
P
L
W
R
F
P
N
E
L
P
-
I
A
G
E
P
A
N
I
V
A
L
V
E
A
Y
M
N
W
L
H
Q
S
-
P
V
P
K
L
L
F
W
G
T
P
G
V
L
I
P
P
A
E
A
A
R
L
A
E
S
L
P
N
C
K
T
V
D
I
G
P
G
L
H
Y
L
Q
E
D
N
P
D
L
I
G
S
E
I
A
R
W
L
P
A
L
------
26
PsiBlast_CBE
76.14
62%
-104
- C1 -
4C6H
3
?
A:
[7-284]
----------
K
K
K
F
A
T
V
H
G
K
Q
M
A
Y
I
E
E
G
--
T
G
--
D
P
I
V
F
L
H
G
N
P
M
S
S
Y
L
W
R
N
I
M
P
H
L
A
G
K
G
R
L
I
A
P
D
L
I
G
M
G
D
S
D
K
L
D
N
S
G
P
D
-
S
Y
T
F
A
E
H
C
T
Y
L
F
A
L
L
E
Q
L
G
V
T
E
N
V
T
L
V
I
H
D
W
G
S
G
L
G
F
H
W
A
H
T
H
S
D
A
V
K
G
I
A
F
M
E
A
I
V
E
T
R
E
-
S
W
D
A
F
P
E
R
A
R
E
M
F
Q
A
L
R
S
P
A
-
G
E
E
M
V
L
E
K
N
L
F
V
E
A
L
V
P
G
S
I
L
R
D
L
T
E
E
E
M
N
E
Y
R
R
P
F
A
N
A
G
E
D
R
R
P
T
L
T
F
P
R
Q
V
P
-
I
E
G
Q
P
K
D
V
T
E
L
V
D
A
Y
V
D
W
L
G
Q
T
-
S
I
P
K
L
F
I
N
A
D
P
G
V
L
I
-
T
G
E
V
R
D
R
V
R
S
W
P
N
L
T
E
V
T
V
-
A
G
L
H
F
I
Q
E
D
S
P
D
E
I
G
A
A
V
-------------
43
PsiBlast_CBE
71.32
40%
-101
- C1 -
2PSD
2
LUCI_RENRE
A:
[20-305]
--------
W
A
R
C
K
Q
M
N
V
L
D
S
F
I
N
Y
Y
D
S
E
--
K
H
AE
N
A
V
I
F
L
H
G
N
A
T
S
S
Y
L
W
R
H
V
V
P
H
I
E
P
V
A
R
C
I
I
P
D
L
I
G
M
G
K
S
G
K
---
S
G
N
G
-
S
Y
R
L
L
D
H
Y
K
Y
L
T
A
W
F
E
L
L
N
L
P
K
K
I
I
F
V
G
H
D
W
G
A
A
L
A
F
H
Y
A
Y
E
H
Q
D
R
I
K
A
I
V
H
M
E
S
V
V
-
D
V
I
E
S
W
D
E
W
P
D
I
E
E
D
I
-
A
L
I
K
S
E
E
-
G
E
K
M
V
L
E
N
N
F
F
V
E
T
V
L
P
S
K
I
M
R
K
L
E
P
E
E
F
A
A
Y
L
E
P
F
K
E
K
G
E
V
R
R
P
T
L
S
W
P
R
E
I
P
L
V
K
G
G
K
P
D
V
V
Q
I
V
R
N
Y
N
A
Y
L
R
A
S
D
D
L
P
K
L
F
I
E
S
D
P
G
-
F
F
-
S
N
A
I
V
E
G
A
K
K
F
P
N
T
E
F
V
K
V
-
K
G
L
H
F
L
Q
E
D
A
P
D
E
M
G
K
Y
I
K
S
F
V
E
R
V
------