@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0056: (2015-12-20 )
MDRLTATRVFVEVIDSGSQTAAAERLDMSRAMVSRYLAELEEWVGARLLHRSTRRLSLTDAGAELLPQCREMLAVADAMQATGQTRRDSPRGTLRITSSLSFAQAWLTRAAAAFVERYPGTAIDLQVNSQVVNLVEERIDLALRIANQLDPNLIARRLGECRSVICAAPDYLRRHGTPRRPEDLALHNCLTYSYFGRSLWQFERDGEPTSVPVGGSLSANESTVLLEAAAAGAGISQQPLYSAAPLIRSGRLVALLPEWSPQVLGIHAVYASRRQMPPALRALLDFLVERMAADPHWDEAGPLALA
Atome Classification :
(20 SA)
----.........10........20........30........40........50........60........70...-....-.--80......-..90........-100........110.......120....---.--..--130..-.-....-..140.---......---150......-.160-.......170...--....-180......-.190...---.-.-.--.--200-..-.....210.....-...220...-.....230........240-.......250..-.....-260........270.......280........290.-......300....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MDR
L
T
A
T
R
V
F
V
E
V
IDSGSQ
T
A
A
A
E
R
L
D
M
S
R
A
M
V
S
R
Y
L
A
E
L
E
E
W
V
G
A
R
L
L
H
RST
R
R
L
SL
T
D
A
G
A
E
L
L
P
Q
C
R
E
M
L
A
-
V
A
D
A
-
M
--
Q
ATGQTRR-DSPR
G
T
L
R
I
TSS-
L
-
S
F
A
Q
A
W
L
T
R
A
A
A
A
F
V
E
RYPG
T
A
I
D
L
Q
---V--
N
S
--
Q
--
V
V
-
N
-
L
V
E
E
-
R
I
D
L
A
L
---
R
I
A
N
QL---
D
P
N
L
I
A
R
R
L
-
G
E
C
R
-
S
V
I
CAA
P
D
Y
L
R
RH--GTPR-R
P
E
D
L
A
L
H
N
-
C
L
T
Y
S
Y
F
---
G
-
R
-
S
--
L
--
W
Q
F-ER-DGEPTSV-PVGGS-LSANE-
S
T
V
-
L
L
E
AAAA-GAGISQQP
L
Y
S-AAPLIRS
G
R
L
V
A
-LLPEW-S-P
Q
V
L
G
I
H
A
V
Y
ASRRQM
P
P
A
L
-
R
A
L
L
D
F
L
V
E
R
MAA-DPHWDEAGPLALA
23
HHSearch
90.95
33%
-116
- C1 -
3HHG
-
?
A:
[2-294]
----
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
-
A
--
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
---
S
--
S
E
--
G
--
Y
I
-
N
-
L
I
E
R
-
K
V
D
I
A
L
---
R
A
G
E
L
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
-
F
R
V
I
A
S
P
E
Y
L
A
K
H
--
G
T
P
Q
-
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
T
E
P
G--
S
-
L
-
N
--
T
--
W
A
V
-
L
D
-
A
Q
-
G
N
P
Y
-
K
I
S
P
H
-
F
T
A
S
S
-
G
E
I
-
L
R
S
L
C
L
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
T
S
-
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
---------------
2
PsiBlast_PDB
89.49
34%
-118
- C1 -
3HHG
-
?
A:
[10-294]
------------
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
-
A
--
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
---
S
--
S
E
--
G
--
Y
I
-
N
-
L
I
E
R
-
K
V
D
I
A
L
---
R
A
G
E
L
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
-
F
R
V
I
A
S
P
E
Y
L
A
K
H
--
G
T
P
Q
-
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
T
E
P
---
G
-
S
L
N
--
T
--
W
A
V
--
L
-
D
A
Q
G
N
P
Y
-
K
I
S
P
H
-
F
T
A
S
S
-
G
E
I
-
L
R
S
L
C
L
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
T
S
-
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
---------------
22
HHSearch
85.52
27%
-114
- C1 -
3SZP
-
?
A:
[1-289]
-----
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
-
M
--
T
E
E
I
T
D
E
C
-
R
G
A
S
G
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
---
M
--
S
N
--
Q
--
A
D
-
D
-
L
D
P
T
-
E
W
D
V
I
F
---
R
V
G
P
Q
R
---
D
S
S
L
I
A
R
K
I
-
G
E
V
K
-
D
I
L
V
A
S
P
Q
Y
L
S
S
H
--
P
Q
P
T
-
H
A
E
E
L
H
Q
H
Q
-
L
L
K
G
Y
P
L
-------
L
--
K
--
W
Q
L
-
T
N
S
Q
G
E
T
V
V
N
-
S
D
R
G
R
-
F
Q
A
S
A
-
L
N
V
-
V
R
S
A
C
S
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
---------------
3
PsiBlast_PDB
84.91
28%
-113
- C1 -
3SZP
-
?
A:
[2-286]
------
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
-
M
T
E
E
I
T
D
E
C
R
G
-
A
S
--
G
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
---
M
--
S
N
--
Q
--
A
D
-
D
-
L
D
P
T
-
E
W
D
V
I
F
---
R
V
G
P
Q
R
---
D
S
S
L
I
A
R
K
I
-
G
E
V
K
-
D
I
L
V
A
S
P
Q
Y
L
S
S
H
--
P
Q
P
T
-
H
A
E
E
L
H
Q
H
Q
-
L
L
K
-------
G
-
Y
-
P
--
L
L
K
W
Q
L
T
N
S
-
Q
G
E
T
V
V
N
-
S
D
R
G
R
-
F
Q
A
S
A
-
L
N
V
-
V
R
S
A
C
S
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
---------------
4
PsiBlast_PDB
83.29
28%
-106
- C1 -
3T1B
-
?
B:
[2-286]
------
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
-
M
T
E
E
I
T
D
E
C
R
G
-
A
S
--
G
R
I
R
I
S
A
P
-
S
-
E
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
---
M
--
S
N
--
Q
--
A
D
---
L
D
P
T
-
E
W
D
V
I
F
---
R
V
G
P
Q
R
---
D
S
S
L
I
A
R
K
I
-
G
E
V
K
-
D
I
L
V
A
S
P
Q
Y
L
S
S
H
--
P
Q
P
T
-
H
A
E
E
L
H
Q
H
Q
-
L
L
K
-------
G
-
Y
-
P
--
L
LK
W
Q
L
T
N
S
-
Q
G
E
T
V
V
N
-
S
D
R
G
R
-
F
Q
A
S
A
-
L
N
V
-
V
R
S
A
C
S
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
---------------
5
PsiBlast_PDB
73.74
32%
-121
- C1 -
3HHF
1
?
B:
[5-208]
--------------------------------------------------------------------------------------------------
P
Q
G
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
---
S
--
S
E
--
G
--
Y
I
-
N
-
L
I
E
R
-
K
V
D
I
A
L
---
R
A
G
--
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
-
F
R
V
I
A
S
P
E
Y
L
A
K
H
--
G
T
P
Q
-
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
T
E
P
---
G
-
S
L
N
--
T
--
W
A
V
--
L
-
D
A
Q
G
N
P
Y
-
K
I
S
P
H
-
F
T
A
S
S
-
G
E
I
-
L
R
S
L
C
L
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
T
S
-
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
---------------
40
HHSearch
73.13
31%
-120
- C1 -
3HHF
1
?
B:
[5-208]
--------------------------------------------------------------------------------------------------
P
Q
G
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
---
S
--
S
E
--
G
--
Y
I
-
N
-
L
I
E
R
-
K
V
D
I
A
L
---
R
A
G
--
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
-
F
R
V
I
A
S
P
E
Y
L
A
K
H
--
G
T
P
Q
-
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
T
E
P
G--
S
-
L
-
N
--
T
--
W
A
V
-
L
D
-
A
Q
-
G
N
P
Y
-
K
I
S
P
H
-
F
T
A
S
S
-
G
E
I
-
L
R
S
L
C
L
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
S
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
---------------
1
PsiBlast_PDB
71.32
33%
-114
- C1 -
3MZ1
-
?
A:
[85-292]
-------------------------------------------------------------------------------------------------
L
P
K
G
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
Q
I
D
L
G
---
V
--
S
D
--
R
--
T
----
Y
L
A
E
-
N
V
D
C
A
I
---
R
A
G
T
L
T
---
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
-
F
V
A
C
A
S
R
D
F
L
E
R
H
--
P
V
P
Q
-
H
P
S
D
L
E
-
K
N
-
C
Y
V
V
G
Y
F
L
PK
Q
-
Q
-
M
--
P
--
F
H
F
-
R
R
-
G
N
E
E
I
E
V
-
S
G
R
Y
T
-
M
A
A
N
E
-
S
T
T
-
Y
L
A
A
A
R
A
-
G
L
G
V
I
Q
A
P
L
F
M
-
V
R
E
D
L
R
N
G
T
M
V
P
-
V
L
P
D
W
-
Q
-
V
E
P
M
P
I
Y
L
V
Y
P
P
N
R
H
L
S
S
R
L
-
R
V
F
A
D
W
V
V
K
V
M
A
Q
-
S
Q
N
----------
27
HHSearch
70.44
33%
-110
- C1 -
3MZ1
-
?
A:
[85-293]
-------------------------------------------------------------------------------------------------
L
P
K
G
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
Q
I
D
L
G
---
V
--
S
D
--
R
--
T
----
Y
L
A
E
-
N
V
D
C
A
I
---
R
A
G
T
L
T
---
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
-
F
V
A
C
A
S
R
D
F
L
E
R
H
--
P
V
P
Q
-
H
P
S
D
L
E
K
N
C
-
Y
V
V
G
Y
F
L
PK--Q
Q
-
M
--
P
--
F
H
F
-
R
R
-
G
N
E
E
I
E
V
-
S
G
R
Y
T
-
M
A
A
N
E
-
S
T
T
-
Y
L
A
A
A
R
A
-
G
L
G
V
I
Q
A
P
L
F
M
-
V
R
E
D
L
R
N
G
T
M
V
P
-
V
L
P
D
W
-
Q
-
V
E
P
M
P
I
Y
L
V
Y
P
P
N
R
H
L
S
S
R
L
-
R
V
F
A
D
W
V
V
K
V
M
A
Q
-
S
Q
N
----------
46
Fugue
70.38
21%
-97
- C1 -
3FZV
1
?
A:
[4-300]
-----
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
G
S
V
A
E
A
S
R
K
L
Y
I
A
Q
S
-
I
S
T
A
V
K
G
L
E
E
S
F
V
Q
---------
L
F
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
L
R
M
A
H
E
F
-
E
--
Q
N
L
--
A
D
N
-
D
V
I
A
G
Q
I
D
I
G
C
F
-
E
-
T
V
A
P
L
Y
L
P
G
L
I
A
G
F
R
Q
A
Y
P
G
V
E
I
R
I
R
---
D
G
E
Q
Q
--
E
--
L
V
-
Q
-
G
L
T
S
G
R
F
D
L
A
F
---
L
Y
E
H
D
L
---
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
-
P
H
A
L
L
P
E
G
H
R
F
A
G
--
Q
A
Q
V
-
S
L
R
D
L
C
L
E
P
M
I
L
L
D
V
Q
P
---
S
-
R
-
T
--
Y
--
F
V
S
-
L
F
-
E
E
L
G
L
T
P
-
N
I
A
F
S
-
S
P
S
I
E
M
V
R
G
M
V
----
G
Q
-
G
F
G
F
S
L
L
V
T
R
P
-
H
S
E
C
T
Y
D
G
K
K
V
V
M
V
D
L
A
E
-
P
-
V
S
T
S
G
L
A
A
A
W
L
K
R
A
Q
L
T
K
P
A
-
R
L
F
V
D
Y
C
R
E
Q
L
G
K
--------------
43
Fugue
69.79
33%
-111
- C1 -
3HHF
1
?
A:
[5-207]
--------------------------------------------------------------------------------------------------
P
Q
G
V
L
S
V
D
S
A
M
P
M
V
L
H
L
--
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
---
S
--
S
E
--
G
--
Y
I
-
N
-
L
I
E
R
-
K
V
D
I
A
L
---
R
A
G
E
L
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
-
F
R
V
I
A
S
P
E
Y
L
A
K
H
--
G
T
P
Q
-
S
T
E
E
L
A
G
H
Q
-
C
L
G
F
T
E
P
---
G
-
S
-
L
N-
T
--
W
A
V
-
L
--
D
A
Q
G
N
P
Y
-
K
I
S
P
H
-
F
T
A
S
S
-
G
E
I
-
L
R
S
L
C
L
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
S
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
---------------
21
HHSearch
69.73
20%
-106
- C1 -
3FXQ
7
TSAR_COMTE
A:
[1-296]
----
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
V
T
-
E
S
R
R
-
A
--
Q
E
E
I
G
Q
L
R
-
G
R
W
E
G
H
I
T
F
A
A
S
-
P
-
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
---
D
--
G
M
--
Y
PA
V
S
-
P
Q
L
R
D
G
-
T
L
D
F
A
L
---
T
A
A
H
K
H
DI-
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
-
V
V
I
V
G
Q
R
Q
H
P
M
A
N
----
A
T
-
R
L
A
E
L
Q
E
C
R
-
W
A
F
S
S
A
P
---
R
-
G
-
P
--
G
--
A
I
I
-
R
N
-
A
F
A
R
Y
G
L
P
E
P
K
L
G
-
L
V
C
E
S
-
F
L
A
-
L
P
G
V
V
A
H
-
S
D
L
L
T
T
M
P
R
T
L
-
Y
E
R
N
A
F
K
D
Q
L
C
S
-
I
P
L
Q
D
-
A
-
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
-
A
G
L
I
R
W
I
Q
H
H
A
L
---------------
44
Fugue
69.33
20%
-89
- C1 -
1IZ1
-
?
A:
[1-292]
----
M
E
-
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
L
E
-
L
A
G
R
-
S
--
G
D
R
S
R
A
A
A
-
R
G
D
V
G
E
L
S
V
A
Y
F
-
G
-
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
--
D
E
--
Q
--
V
E
-
G
-
L
L
A
G
-
T
I
H
V
G
F
---
S
R
F
F
P
R
---
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
-
L
Y
L
A
V
H
R
S
Q
S
G
K
F
--
G
K
T
C
-
K
L
A
D
L
R
A
V
E
-
L
T
L
F
P
R
G
---
G
-
R
-
P
S
F
A
--
D
E
V
-
I
G
-
L
F
K
H
A
G
I
-
E
P
R
I
A
-
R
V
V
E
D
-
A
T
A
-
A
L
A
L
T
M
A
-
G
A
A
S
S
I
V
P
A
S
V
-
A
A
I
R
W
P
D
I
A
F
A
R
-
I
V
G
---
T
-
R
V
K
V
P
I
S
C
I
F
R
K
E
K
Q
-
P
P
I
L
-
A
R
F
V
E
H
V
R
R
S
A
----------------
25
HHSearch
64.84
16%
-95
- C1 -
2ESN
-
?
A:
[7-303]
----
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
-
G
--
L
E
E
W
R
P
F
V
P
G
Q
S
Q
R
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
---
N
--
A
E
--
R
KL
S
V
-
E
A
L
A
S
G
-
R
I
D
F
A
L
---
G
Y
D
E
E
H
ERL
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
-
Y
V
V
V
A
R
R
D
H
P
R
L
A
--
G
-
A
P
-
T
L
E
G
Y
L
A
E
R
-
H
A
V
V
T
P
W
---
N
-
E
-
D
--
S
--
G
V
I
-
D
R
-
L
L
A
R
S
G
L
-
R
R
E
V
A
-
V
Q
L
P
T
-
V
L
A
-
A
L
F
L
A
G
S
-
T
D
F
L
L
T
A
P
R
H
A
-
A
R
A
L
A
E
A
A
G
L
A
L
-
Y
P
A
P
F
-
D
-
I
P
P
Y
V
L
R
L
Y
S
H
V
Q
--
G
R
D
A
H
-
A
W
M
I
G
Q
L
K
G
L
D
----------------
50
Fugue
64.39
16%
-92
- C1 -
2ESN
-
?
A:
[3-303]
PLLR
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
G
L
--
E
E
W
R
P
F
V
P
-
G
Q
S
Q
R
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
NAE
R
--
K
L
--
S
--
V
E
-
A
-
L
A
S
G
-
R
I
D
F
A
L
G
Y
D
E
E
H
E
R
L
---
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
-
Y
V
V
V
A
R
R
D
H
-
P
R
L
--
A
G
A
P
-
T
L
E
G
Y
L
A
E
R
-
H
A
V
V
T
P
W
---
N
-
E
-
D
--
S
--
G
V
I
-
D
R
-
L
L
A
R
S
G
L
-
R
R
E
V
A
-
V
Q
L
P
T
-
V
L
A
-
A
L
F
L
A
G
S
-
T
D
F
L
L
T
A
P
R
H
A
-
A
R
A
L
A
E
A
A
G
L
A
L
-
Y
P
A
P
F
-
D
-
I
P
P
Y
V
L
R
L
Y
S
H
V
Q
G
R
--
D
A
H
-
A
W
M
I
G
Q
L
K
G
L
D
----------------
32
HHSearch
61.61
19%
-92
- C1 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
A
L
-
L
E
S
E
-
A
--
L
A
E
M
G
--
A
-
S
L
K
R
T
R
I
T
I
A
V
N
-
A
-
D
S
M
A
T
W
F
S
A
V
F
D
----
G
L
G
D
V
L
L
D
V
R
---
I
--
E
D
Q
D
H
--
S
A
-
R
L
L
R
E
G
-
V
A
M
G
A
V
---
T
T
E
R
N
P
---
V
P
G
C
R
V
H
P
L
-
G
E
M
R
-
Y
L
P
V
A
S
R
P
F
V
Q
R
H
L-
S
D
G
F
-
T
A
A
A
A
A
K
A
P
-
S
L
A
W
N
R
D
D--
G
-
L
-
Q
--
D
--
M
L
V
-
R
K
-
A
F
R
R
A
I
---
T
R
P
T
-
H
F
V
P
T
-
T
E
G
-
F
T
A
A
A
R
A
-
G
L
G
W
G
M
F
P
E
K
L
-
A
A
S
P
L
A
D
G
S
F
V
R
-
V
C
D
-
I
-----
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
-
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
G
Q
---------
45
Fugue
57.51
17%
-90
- C1 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
A
L
-
L
E
S
E
-
A
--
L
--
A
E
M
G
A
-
S
L
K
R
T
R
I
T
I
A
V
N
-
A
-
D
S
M
A
T
W
F
S
A
V
F
D
G
L
G
D
V
L
L
D
V
R
I
E
-----
D
--
Q
D
--
H
--
S
A
-
R
-
L
L
R
E
G
V
A
M
G
A
V
---
T
T
E
R
N
P
---
V
P
G
C
R
V
H
P
L
-
G
E
M
R
-
Y
L
P
V
A
S
R
P
F
V
Q
R
H
--
L
S
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
A
W
N
R
D
---
D
-
G
-
L
--
Q
--
D
M
L
-
V
R
-
K
A
F
R
R
A
I
-
T
R
P
T
H
-
F
V
P
T
--
T
E
G
-
F
T
A
A
A
R
A
-
G
L
G
W
G
M
F
P
E
K
L
-
A
A
S
P
L
A
D
G
S
F
V
R
-
V
C
D
I
H
-
L
-
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
-
D
T
V
R
A
A
A
S
G
L
Y
R
G
-
Q
------------
48
Fugue
55.18
19%
-91
- C1 -
3KOS
9
AMPR_CITFR
A:
[11-210]
---------------------------------------------------------------------------------------------------
Q
E
K
L
K
I
G
V
V
-
G
-
T
F
A
I
G
C
L
F
P
L
L
S
D
F
K
R
S
Y
P
H
I
D
L
H
I
S
---
T
--
H
N
--
N
--
R
V
-
D
-
P
A
A
E
-
G
L
D
Y
T
I
---
R
Y
G
G
G
A
---
W
H
D
T
D
A
Q
Y
L
-
C
S
A
L
M
S
P
L
C
S
-
P
T
L
A
S
Q
-----
I
Q
-
T
P
A
D
I
L
K
F
P
-
L
L
R
-
S
Y
R
---
R
-
D
-
E
--
W
--
A
L
W
M
Q
T
-
V
G
E
A
P
P
S
-
P
T
H
N
V
M
V
F
D
S
--
S
V
T
M
L
E
A
A
Q
A
G
M
G
V
A
I
A
---
P
V
R
M
F
T
H
L
L
S
S
E
R
I
V
Q
-
P
F
L
T
Q
-
I
-
D
L
--
G
S
Y
W
I
T
R
L
Q
S
R
P
E
T
P
A
M
R
E
F
S
R
W
L
T
G
V
L
H
K
-
T
------------
31
HHSearch
53.26
22%
-76
- C1 -
2H9B
5
BENM_ACIAD
A:
[89-295]
---------------------------------------------------------------------------------------------------
E
K
T
I
R
I
G
F
V
-
G
-
S
L
L
F
G
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
---
E
--
M
G
--
T
K
A
Q
T
E
A
-
L
K
E
G
-
R
I
D
A
G
F
---
G
R
L
K
I
S
---
D
P
A
I
K
H
S
L
L
-
R
N
E
R
-
L
M
V
A
V
H
A
S
H
P
L
N
Q
MK
D
K
G
V
-
H
L
N
D
L
I
D
E
K
-
I
L
L
Y
P
S
S
---
P
K
P
-
N
F
-
S
--
T
H
V
-
M
N
-
I
F
S
D
H
G
L
-
E
P
T
K
I
-
N
E
V
R
E
-
V
Q
L
-
A
L
G
L
V
A
A
-
G
E
G
I
S
L
V
P
A
S
T
-
Q
S
I
Q
L
F
N
L
S
Y
V
P
-
L
L
D
---
P
-
D
A
I
T
P
I
Y
I
A
V
R
N
M
E
-
E
S
T
Y
I
-
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
-
E
G
F
T
E
P
P
N
W
----
39
HHSearch
52.36
17%
-85
* C1 *
2FYI
-
CBL_ECOLI
A:
[89-296]
------------------------------------------------------------------------------------------------
N
D
T
S
G
V
L
T
I
A
T
T
-
H
-
T
Q
A
R
Y
S
L
P
E
V
I
K
A
F
R
E
L
F
P
E
V
R
L
E
L
I
---
Q
--
G
T
--
P
Q
E
I
A
-
T
L
L
Q
N
G
-
E
A
D
I
G
I
---
A
S
E
R
L
S
N--
D
P
Q
L
V
A
F
P
W
-
F
R
W
H
-
H
S
L
L
V
P
H
D
H
P
L
T
Q
--
I
S
P
L
-
T
L
E
S
I
A
K
W
P
-
L
I
T
Y
R
Q
G
---
I
T
G
-
R
--
S
--
R
-
I
-
D
D
-
A
F
A
R
K
G
L
-
L
A
D
I
V
-
L
S
A
Q
D
-
S
D
V
-
I
K
T
Y
V
A
L
-
G
L
G
I
G
L
V
A
E
Q
S
-
S
G
E
Q
-
E
E
E
N
L
I
R
-
L
D
T
R
H
-
L
-
F
D
A
N
T
V
W
L
G
L
K
R
G
Q
L
Q
R
N
Y
V
-
W
R
F
L
E
L
C
N
A
G
L
S
V
-
E
D
I
K
R
Q
V
M
E
S
---