@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0845: (2016-01-21 )
MSRSAFTALLLSCVLLALSMPARADDLPYRFGLGKADITGEAAEVGMMGYSSLEQKTAGIHMRQWARAFVIEEAASGRRLVYVNTDLGMIFQAVHLKVLARLKAKYPGVYDENNVMLAATHTHSGPGGFSHYAMYNLSVLGFQEKTFNAIVDGIVRSIERAQARLQPGRLFYGSGELRNANRNRSLLSHLKNPDIVGYEDGIDPQMSVLSFVDANGELAGAISWFPVHSTSMTNANHLISPDNKGYASYHWEHDVSRKSGFVAAFAQTNAGNLSPNLNLKPGSGPFDNEFDNTREIGLRQFAKAYEIAGQAQEEVLGELDSRFRFVDFTRLPIRPEFTDGQPRQLCTAAIGTSLAAGSTEDGPGPLGLEEGNNPFLSALGGLLTGVPPQELVQCQAEKTILADTGNKKPYPWTPTVLPIQMFRIGQLELLGAPAEFTVMAGVRIRRAVQAASEAAGIRHVVFNGYANAYASYVTTREEYAAQEYEGGSTLYGPWTQAAYQQLFVDMAVALRERLPVETSAIAPDLSCCQMNFQTGVVADDPYIGKSFGDVLQQPRESYRIGDKVTVAFVTGHPKNDLRTEKTFLEVVNIGKDGKQTPETVATDNDWDTQYRWERVGISASKATISWSIPPGTEPGHYYIRHYGNAKNFWTQKISEIGGSTRSFEVLGTTP
Atome Classification :
(20 SA)
---------------------------------------------------------------.........10........20....-....30...-.....40----.........50....----....60.......----------.70........80......--..90........100.-......110.---..----------..--..120......----.130.....--..140.....------..150.....-..160.......170.......180-.......190.--......200....-...210---.-..-....220---.......230--.........240.--......250.-....-----.---.260....---------...270-.-..-------..------------------------..280.....--------..290.......300..--------.------....310-.......320.-......-330--.....-...340.....---.-----------.---------------------.350......----.360...----------....370----.....---------------..380-----.-----...----..---.390..--....-.400....-...410-......-----------------------..420........430.......440------------------------......-----.450....----------------------...--460..-----.....470.---------------......480.......490...---....500....-...510.......520.......530...---------..---...540.------......550..---.---....560-----------........570.....--.--.580.......590--------.--......600.......610.......--.620.....----------.--.630.......-----------.640.------......650---..-----------------------.....660.......670-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------MS
R
S
A
F
T
A
L
L
L
S
C
V
L
L
A
LSMPARAD-DLPYRFGLG-KADITG-----
E
A
A
E
V
G
MM
G
Y
S
S
L
E
Q
----
K
T
AG
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
EAASG
R
R
L
V
Y
V
NT
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-AKYPGVYDEN---
N
V
----------
M
L
--
A
A
THTHSGPGG----F
S
H
Y
A
M
Y
N
L
--
S
V
LGF
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
ARLQPG
R
L
F
YGSGELRNANR-
N
R
S
L
L
S
HLKNP--DIVGYEDGID
P
Q
M
-
S
V
L
S
FV---D-AN-G
E
L
A
G
A
I
---
S
W
F
PVHST----SMTNANHLISPDN--KG
Y
A
S
Y
H
WEH-DVSR-----K---S
G
F
V
A
A
F
A
---------QTNAGN-L-SP-------NL------------------------NLKPGSGPFD--------NEFD
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
IAG
Q
A
Q
-
E
E
V
L
G
E
L
D
SR
F
-
R
F
V
D
FT-RL---PIRPE-FTDG
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
IGTSLAAGS----TEDGPGP----------LGLEEGN----
N
P
F
L
S
---------------
A
L
G
G
L
-----L-----TGV----
P
P
---
Q
E
L
V
Q
C
--QAE
K
-
T
I
L
ADTGN-KKPYP--WT
P
T
V
L
-----------------------
P
I
Q
-
M
F
RIG
Q
L
E
L
LGAPA
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
AAG----------------------
I
R
H
--
V
V
FNG-----Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
EYEGG
S
T
L
YG
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
RLPVETSAIAPD
L
S
C
C
Q
M
N-FQT---------GV---VADDPYI------
G
K
S
F
G
D
V
L
QQ
P
---
R
---
E
SYRIG------------D
K
V
T
V
A
F
VTGHPKNDL--
R
--
T
E
K
T
F
L
E
V
V
NIGKD--------G--KQTPETVATDNDWDT
Q
Y
-
R
W
E
RVGIS--AS
K
A
T
I
S
W
S----------I--PP-GTEPG
H
Y
Y
-----------
I
R
H
YG------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
IGGST
R
S
F
E
V
LGTTP-------------------
2
PsiBlast_PDB
99.45
99%
-71
- C6 -
2ZWS
23
NCASE_PSEAE
A:
[1-645]
---------------------------------------------------------------------------------------
D
-
D
L
P
Y
R
F
G
L
G
-
K
A
D
I
T
G
-----
E
A
A
E
V
G
M
M
G
Y
S
S
L
E
Q
----
K
T
A
G
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
E
A
A
S
G
R
R
L
V
Y
V
N
T
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-
A
K
Y
P
G
V
Y
D
E
N
---
N
V
----------
M
L
--
A
A
T
H
T
H
S
G
P
G
G
----
F
S
H
Y
A
M
Y
N
L
--
S
V
L
G
F
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
A
R
L
Q
P
G
R
L
F
Y
G
S
G
E
L
R
N
A
S
R
-
N
R
S
L
L
S
H
L
K
N
P
--
D
I
A
G
Y
E
D
G
I
D
P
Q
M
-
S
V
L
S
F
V
---
D
-
A
N
-
G
E
L
A
G
A
I
---
S
W
F
P
V
H
S
T
----
S
M
T
N
A
N
H
L
I
S
P
D
N
--
K
G
Y
A
S
Y
H
W
E
H
-
D
V
S
R
-----
K
---
S
G
F
V
A
A
F
A
---------
Q
T
N
A
G
N
-
L
-
S
P
-------
N
L
------------------------
N
L
K
P
G
S
G
P
F
D
--------
N
E
F
D
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
I
A
G
Q
A
Q
-
E
E
V
L
G
E
L
D
S
R
F
-
R
F
V
D
F
T
-
R
L
---
P
I
R
P
E
-
F
T
D
G
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
I
G
T
-----------------------------
L
E
E
G
N
----
N
P
F
L
S
---------------
A
L
G
G
L
-----
L
-----
T
G
V
----
P
P
---
Q
E
L
V
Q
C
--
Q
A
E
K
-
T
I
L
A
D
T
G
N
-
K
K
P
Y
P
--
W
T
P
T
V
L
-----------------------
P
I
Q
-
M
F
R
I
G
Q
L
E
L
L
G
A
P
A
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
A
A
G
----------------------
I
R
H
--
V
V
F
N
G
-----
Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
E
Y
E
G
G
S
T
L
Y
G
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
R
L
P
V
E
T
S
A
I
A
P
D
L
S
C
C
Q
M
N
-
F
Q
T
---------
G
V
---
V
A
D
D
P
Y
I
------
G
K
S
F
G
D
V
L
Q
Q
P
---
R
---
E
S
Y
R
I
G
------------
D
K
V
T
V
A
F
V
T
G
H
P
K
N
D
L
--
R
--
T
E
K
T
F
L
E
V
V
N
I
G
K
D
--------
G
--
K
Q
T
P
V
T
V
A
T
D
N
D
W
D
T
Q
Y
-
R
W
E
R
V
G
I
S
--
A
S
K
A
T
I
S
W
S
----------
I
--
P
P
-
G
T
E
P
G
H
Y
Y
-----------
I
R
H
Y
G
------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
I
G
G
S
T
R
S
F
E
V
L
G
T
T
--------------------
20
HHSearch
99.32
100%
-71
- C6 -
2ZWS
23
NCASE_PSEAE
A:
[2-645]
-----------------------------------------------------------------------------------------
D
L
P
Y
R
F
G
L
G
-
K
A
D
I
T
G
-----
E
A
A
E
V
G
M
M
G
Y
S
S
L
E
Q
----
K
T
A
G
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
E
A
A
S
G
R
R
L
V
Y
V
N
T
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-
A
K
Y
P
G
V
Y
D
E
N
---
N
V
----------
M
L
--
A
A
T
H
T
H
S
G
P
G
G
----
F
S
H
Y
A
M
Y
N
L
--
S
V
L
G
F
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
A
R
L
Q
P
G
R
L
F
Y
G
S
G
E
L
R
N
A
S
R
-
N
R
S
L
L
S
H
L
K
N
P
--
D
I
A
G
Y
E
D
G
I
D
P
Q
M
-
S
V
L
S
F
V
---
D
-
A
N
-
G
E
L
A
G
A
I
---
S
W
F
P
V
H
S
T
----
S
M
T
N
A
N
H
L
I
S
P
D
N
--
K
G
Y
A
S
Y
H
W
E
H
-
D
V
S
R
-----
K
---
S
G
F
V
A
A
F
A
---------
Q
T
N
A
G
N
-
L
-
S
P
-------
N
L
------------------------
N
L
K
P
G
S
G
P
F
D
--------
N
E
F
D
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
I
A
G
Q
A
Q
-
E
E
V
L
G
E
L
D
S
R
F
-
R
F
V
D
F
T
-
R
L
---
P
I
R
P
E
-
F
T
D
G
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
I
G
T
-----------------------------
L
E
E
G
N
----
N
P
F
L
S
---------------
A
L
G
G
L
-----
L
-----
T
G
V
----
P
P
---
Q
E
L
V
Q
C
--
Q
A
E
K
-
T
I
L
A
D
T
G
N
-
K
K
P
Y
P
--
W
T
P
T
V
L
-----------------------
P
I
Q
-
M
F
R
I
G
Q
L
E
L
L
G
A
P
A
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
A
A
G
----------------------
I
R
H
--
V
V
F
N
G
-----
Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
E
Y
E
G
G
S
T
L
Y
G
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
R
L
P
V
E
T
S
A
I
A
P
D
L
S
C
C
Q
M
N
-
F
Q
T
---------
G
V
---
V
A
D
D
P
Y
I
------
G
K
S
F
G
D
V
L
Q
Q
P
---
R
---
E
S
Y
R
I
G
------------
D
K
V
T
V
A
F
V
T
G
H
P
K
N
D
L
--
R
--
T
E
K
T
F
L
E
V
V
N
I
G
K
D
--------
G
--
K
Q
T
P
V
T
V
A
T
D
N
D
W
D
T
Q
Y
-
R
W
E
R
V
G
I
S
--
A
S
K
A
T
I
S
W
S
----------
I
--
P
P
-
G
T
E
P
G
H
Y
Y
-----------
I
R
H
Y
G
------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
I
G
G
S
T
R
S
F
E
V
L
G
T
T
--------------------
30
Fugue
99.14
99%
-69
- C6 -
2ZXC
7
NCASE_PSEAE
A:
[2-644]
-----------------------------------------------------------------------------------------
D
L
P
Y
R
F
G
L
G
-
K
A
D
I
T
G
-----
E
A
A
E
V
G
M
M
G
Y
S
S
L
E
Q
----
K
T
A
G
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
E
A
A
S
G
R
R
L
V
Y
V
N
T
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-
A
K
Y
P
G
V
Y
D
E
N
---
N
V
----------
M
L
--
A
A
T
H
T
H
S
G
P
G
G
----
F
S
H
Y
A
M
Y
N
L
--
S
V
L
G
F
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
A
R
L
Q
P
G
R
L
F
Y
G
S
G
E
L
R
N
A
S
R
-
N
R
S
L
L
S
H
L
K
N
P
--
D
I
A
G
Y
E
D
G
I
D
P
Q
M
-
S
V
L
S
F
V
---
D
-
A
N
-
G
E
L
A
G
A
I
---
S
W
F
P
V
H
S
T
----
S
M
T
N
A
N
H
L
I
S
P
D
N
--
K
G
Y
A
S
Y
H
W
E
H
-
D
V
S
R
-----
K
---
S
G
F
V
A
A
F
A
---------
Q
T
N
A
G
N
-
L
-
S
P
-------
N
L
------------------------
N
L
K
P
G
S
G
P
F
D
--------
N
E
F
D
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
I
A
G
Q
A
Q
-
E
E
V
L
G
E
L
D
S
R
F
-
R
F
V
D
F
T
-
R
L
---
P
I
R
P
E
-
F
T
D
G
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
I
G
T
S
L
A
A
G
S
----
T
E
D
G
P
G
P
----------
L
G
L
E
E
G
N
----
N
P
F
L
S
---------------
A
L
G
G
L
-----
L
-----
T
G
V
----
P
P
---
Q
E
L
V
Q
C
--
Q
A
E
K
-
T
I
L
A
D
T
G
N
-
K
K
P
Y
P
--
W
T
P
T
V
L
-----------------------
P
I
Q
-
M
F
R
I
G
Q
L
E
L
L
G
A
P
A
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
A
A
G
----------------------
I
R
H
--
V
V
F
N
G
-----
Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
E
Y
E
G
G
S
T
L
Y
G
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
R
L
P
V
E
T
S
A
I
A
P
D
L
S
C
C
Q
M
N
-
F
Q
T
---------
G
V
---
V
A
D
D
P
Y
I
------
G
K
S
F
G
D
V
L
Q
Q
P
---
R
---
E
S
Y
R
I
G
------------
D
K
V
T
V
A
F
V
T
G
H
P
K
N
D
L
--
R
--
T
E
K
T
F
L
E
V
V
N
I
G
K
D
--------
G
--
K
Q
T
P
V
T
V
A
T
D
N
D
W
D
T
Q
Y
-
R
W
E
R
V
G
I
S
--
A
S
K
A
T
I
S
W
S
----------
I
--
P
P
-
G
T
E
P
G
H
Y
Y
-----------
I
R
H
Y
G
------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
I
G
G
S
T
R
S
F
E
V
L
G
T
---------------------
1
PsiBlast_PDB
99.14
99%
-69
- C6 -
2ZXC
7
NCASE_PSEAE
A:
[2-644]
-----------------------------------------------------------------------------------------
D
L
P
Y
R
F
G
L
G
-
K
A
D
I
T
G
-----
E
A
A
E
V
G
M
M
G
Y
S
S
L
E
Q
----
K
T
A
G
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
E
A
A
S
G
R
R
L
V
Y
V
N
T
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-
A
K
Y
P
G
V
Y
D
E
N
---
N
V
----------
M
L
--
A
A
T
H
T
H
S
G
P
G
G
----
F
S
H
Y
A
M
Y
N
L
--
S
V
L
G
F
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
A
R
L
Q
P
G
R
L
F
Y
G
S
G
E
L
R
N
A
S
R
-
N
R
S
L
L
S
H
L
K
N
P
--
D
I
A
G
Y
E
D
G
I
D
P
Q
M
-
S
V
L
S
F
V
---
D
-
A
N
-
G
E
L
A
G
A
I
---
S
W
F
P
V
H
S
T
----
S
M
T
N
A
N
H
L
I
S
P
D
N
--
K
G
Y
A
S
Y
H
W
E
H
-
D
V
S
R
-----
K
---
S
G
F
V
A
A
F
A
---------
Q
T
N
A
G
N
-
L
-
S
P
-------
N
L
------------------------
N
L
K
P
G
S
G
P
F
D
--------
N
E
F
D
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
I
A
G
Q
A
Q
-
E
E
V
L
G
E
L
D
S
R
F
-
R
F
V
D
F
T
-
R
L
---
P
I
R
P
E
-
F
T
D
G
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
I
G
T
S
L
A
A
G
S
----
T
E
D
G
P
G
P
----------
L
G
L
E
E
G
N
----
N
P
F
L
S
---------------
A
L
G
G
L
-----
L
-----
T
G
V
----
P
P
---
Q
E
L
V
Q
C
--
Q
A
E
K
-
T
I
L
A
D
T
G
N
-
K
K
P
Y
P
--
W
T
P
T
V
L
-----------------------
P
I
Q
-
M
F
R
I
G
Q
L
E
L
L
G
A
P
A
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
A
A
G
----------------------
I
R
H
--
V
V
F
N
G
-----
Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
E
Y
E
G
G
S
T
L
Y
G
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
R
L
P
V
E
T
S
A
I
A
P
D
L
S
C
C
Q
M
N
-
F
Q
T
---------
G
V
---
V
A
D
D
P
Y
I
------
G
K
S
F
G
D
V
L
Q
Q
P
---
R
---
E
S
Y
R
I
G
------------
D
K
V
T
V
A
F
V
T
G
H
P
K
N
D
L
--
R
--
T
E
K
T
F
L
E
V
V
N
I
G
K
D
--------
G
--
K
Q
T
P
V
T
V
A
T
D
N
D
W
D
T
Q
Y
-
R
W
E
R
V
G
I
S
--
A
S
K
A
T
I
S
W
S
----------
I
--
P
P
-
G
T
E
P
G
H
Y
Y
-----------
I
R
H
Y
G
------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
I
G
G
S
T
R
S
F
E
V
L
G
T
---------------------
18
PsiBlast_CBE
99.05
99%
-67
- C6 -
2ZXC
9
NCASE_PSEAE
B:
[2-644]
-----------------------------------------------------------------------------------------
D
L
P
Y
R
F
G
L
G
-
K
A
D
I
T
G
-----
E
A
A
E
V
G
M
M
G
Y
S
S
L
E
Q
----
K
T
A
G
I
H
M
R
Q
W
A
R
A
----------
F
V
I
E
E
A
A
S
G
R
R
L
V
Y
V
N
T
D
L
--
G
M
I
F
Q
A
V
H
L
K
V
L
A
R
L
K
-
A
K
Y
P
G
V
Y
D
E
N
---
N
V
----------
M
L
--
A
A
T
H
T
H
S
G
P
G
G
----
F
S
H
Y
A
M
Y
N
L
--
S
V
L
G
F
Q
E
K
T
F
------
N
A
I
V
D
G
I
V
R
S
-
I
E
R
A
Q
A
R
L
Q
P
G
R
L
F
Y
G
S
G
E
L
R
N
A
S
R
-
N
R
S
L
L
S
H
L
K
N
P
--
D
I
A
G
Y
E
D
G
I
D
P
Q
M
-
S
V
L
S
F
V
---
D
-
A
N
-
G
E
L
A
G
A
I
---
S
W
F
P
V
H
S
T
----
S
M
T
N
A
N
H
L
I
S
P
D
N
--
K
G
Y
A
S
Y
H
W
E
H
-
D
V
S
R
-----
K
---
S
G
F
V
A
A
F
A
---------
Q
T
N
A
G
N
-
L
-
S
P
-------
N
L
------------------------
N
L
K
P
G
S
G
P
F
D
--------
N
E
F
D
N
T
R
E
I
G
L
R
Q
F
A
K
A
--------
Y
------
E
I
A
G
Q
A
Q
-
E
E
V
L
G
E
L
D
S
R
F
-
R
F
V
D
F
T
-
R
L
---
P
I
R
P
E
-
F
T
D
G
Q
-
P
R
Q
L
C
---
T
-----------
A
---------------------
A
I
G
T
S
L
A
A
G
S
----
T
E
D
G
P
G
P
----------
L
G
L
E
E
G
N
----
N
P
F
L
S
---------------
A
L
G
G
L
-----
L
-----
T
G
V
----
P
P
---
Q
E
L
V
Q
C
--
Q
A
E
K
-
T
I
L
A
D
T
G
N
-
K
K
P
Y
P
--
W
T
P
T
V
L
-----------------------
P
I
Q
-
M
F
R
I
G
Q
L
E
L
L
G
A
P
A
E
F
T
V
M
A
G
V
------------------------
R
I
R
R
A
V
-----
Q
A
A
S
E
A
A
G
----------------------
I
R
H
--
V
V
F
N
G
-----
Y
A
N
A
Y
A
S
Y
V
---------------
T
T
R
E
E
Y
A
A
Q
E
Y
E
G
G
S
T
L
Y
G
P
W
T
---
Q
A
A
Y
Q
Q
L
F
V
D
M
-
A
V
A
L
R
E
R
L
P
V
E
T
S
A
I
A
P
D
L
S
C
C
Q
M
N
-
F
Q
T
---------
G
V
---
V
A
D
D
P
Y
I
------
G
K
S
F
G
D
V
L
Q
Q
P
---
R
---
E
S
Y
R
I
G
------------
D
K
V
T
V
A
F
V
T
G
H
P
K
N
D
L
--
R
--
T
E
K
T
F
L
E
V
V
N
I
G
K
D
--------
G
--
K
Q
T
P
V
T
V
A
T
D
N
D
W
D
T
Q
Y
-
R
W
E
R
V
G
I
S
--
A
S
K
A
T
I
S
W
S
----------
I
--
P
P
-
G
T
E
P
G
H
Y
Y
-----------
I
R
H
Y
G
------
N
A
K
N
F
W
T
Q
K
---
I
S
-----------------------
E
I
G
G
S
T
R
S
F
E
V
L
G
T
---------------------
3
PsiBlast_PDB
82.03
36%
-57
- C6 -
4WGK
10
?
A:
[4-680]
--------------------------------------------------------------------------------------------
Y
H
I
G
V
G
-
R
A
D
C
T
G
-----
Q
V
A
D
I
N
L
M
G
Y
G
K
S
G
Q
----
N
A
Q
G
I
L
T
R
L
Y
S
R
A
----------
F
I
M
A
E
P
D
G
S
N
R
T
V
F
V
S
I
D
I
--
G
M
V
S
Q
R
L
R
L
E
V
L
N
R
L
Q
-
S
K
Y
G
S
L
Y
R
R
D
---
N
V
----------
I
L
--
S
G
T
H
T
H
S
G
P
A
G
----
Y
F
Q
Y
T
V
F
V
I
--
A
S
E
G
F
S
N
Q
T
F
------
Q
H
M
V
T
G
I
L
K
S
-
I
D
I
A
H
T
N
M
K
P
G
K
I
F
I
N
K
G
N
V
D
G
V
Q
I
-
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
-
I
V
L
K
M
V
---
D
-
L
N
-
G
D
D
L
G
L
I
---
S
W
F
A
I
H
P
V
----
S
M
N
N
S
N
H
L
V
N
S
D
N
--
V
G
Y
A
S
Y
L
L
E
Q
-
E
K
N
K
GYLPG
Q
---
G
P
F
V
A
A
F
A
---------
S
S
N
L
G
D
-
V
-
S
P
-------
N
I
LGPRCINTGESCDNANSTCPIGGP
S
M
C
I
A
K
G
P
G
Q
--------
D
M
F
D
S
T
Q
I
I
G
R
A
M
Y
Q
R
A
--------
K
------
E
L
Y
A
S
A
S
-
Q
E
V
T
G
P
L
A
S
A
H
-
Q
W
V
D
M
T
-
D
V
---
T
V
W
L
N
-
S
T
H
A
S
---
K
T
C
---
K
-----------
P
---------------------
A
L
G
Y
S
F
A
A
G
-----
T
I
D
G
V
G
G
----------
L
N
F
T
Q
G
K
TEG-
D
P
F
W
D
---------------
T
I
R
D
Q
-----
I
-----
L
G
K
----
P
S
---
E
E
I
K
E
C
--
H
K
P
K
-
P
I
L
L
H
T
G
E
L
S
K
P
H
P
--
W
H
P
D
I
V
-----------------------
D
V
Q
-
I
I
T
L
G
S
L
A
I
T
A
I
P
G
E
F
T
T
M
S
G
R
------------------------
R
L
R
E
A
V
-----
Q
A
E
F
A
S
H
G
----------------------
M
Q
N
M
T
V
V
I
S
G
-----
L
C
N
V
Y
T
H
Y
I
---------------
T
T
Y
E
E
Y
Q
A
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
---
L
S
A
Y
I
Q
L
F
R
N
L
-
A
K
A
I
A
T
D
T
-
V
A
N
L
S
R
G
P
E
P
P
F
-----
F
K
Q
-----------------
I
P
S
I
V
D
R
A
P
K
G
R
T
F
G
D
V
L
Q
P
A
---
K
---
P
E
Y
R
V
G
------------
E
V
A
E
V
I
F
V
G
A
N
P
K
N
S
V
Q----
T
H
Q
T
F
L
T
V
E
K
Y
-
E
A
--------
T
--
S
T
S
W
Q
I
V
C
N
D
A
S
W
E
T
R
F
-
Y
W
H
K
G
L
L
G
--
L
S
N
A
T
V
E
W
H
----------
I
--
P
D
-
T
A
Q
P
G
I
Y
R
-----------
I
R
Y
F
G
------
H
N
R
K
Q
----P
A
V
I
L
-----------------------
S
F
E
G
T
S
P
A
F
E
V
V
T
I
---------------------
19
PsiBlast_CBE
81.73
36%
-58
- C6 -
4WGK
12
?
B:
[4-680]
--------------------------------------------------------------------------------------------
Y
H
I
G
V
G
-
R
A
D
C
T
G
-----
Q
V
A
D
I
N
L
M
G
Y
G
K
S
G
Q
----
N
A
Q
G
I
L
T
R
L
Y
S
R
A
----------
F
I
M
A
E
P
D
G
S
N
R
T
V
F
V
S
I
D
I
--
G
M
V
S
Q
R
L
R
L
E
V
L
N
R
L
Q
-
S
K
Y
G
S
L
Y
R
R
D
---
N
V
----------
I
L
--
S
G
T
H
T
H
S
G
P
A
G
----
Y
F
Q
Y
T
V
F
V
I
--
A
S
E
G
F
S
N
Q
T
F
------
Q
H
M
V
T
G
I
L
K
S
-
I
D
I
A
H
T
N
M
K
P
G
K
I
F
I
N
K
G
N
V
D
G
V
Q
I
-
N
R
S
P
Y
S
Y
L
Q
N
P
Q
S
E
R
A
R
Y
S
S
N
T
D
K
E
M
-
I
V
L
K
M
V
---
D
-
L
N
-
G
D
D
L
G
L
I
---
S
W
F
A
I
H
P
V
----
S
M
N
N
S
N
H
L
V
N
S
D
N
--
V
G
Y
A
S
Y
L
L
E
Q
-
E
K
N
K
GYLPG
Q
---
G
P
F
V
A
A
F
A
---------
S
S
N
L
G
D
-
V
-
S
P
-------
N
I
LGPRCINTGESCDNANSTCPIGGP
S
M
C
I
A
K
G
P
G
Q
--------
D
M
F
D
S
T
Q
I
I
G
R
A
M
Y
Q
R
A
--------
K
------
E
L
Y
A
S
A
S
-
Q
E
V
T
G
P
L
A
S
A
H
-
Q
W
V
D
M
T
-
D
V
---
T
V
W
L
N
-
S
T
H
A
S
---
K
T
C
---
K
-----------
P
---------------------
A
L
G
Y
S
F
A
A
G
-----
T
I
D
G
V
G
G
----------
L
N
F
T
Q
G
K
TEG-
D
P
F
W
D
---------------
T
I
R
D
Q
-----
I
-----
L
G
K
----
P
S
---
E
E
I
K
E
C
--
H
K
P
K
-
P
I
L
L
H
T
G
E
L
S
K
P
H
P
--
W
H
P
D
I
V
-----------------------
D
V
Q
-
I
I
T
L
G
S
L
A
I
T
A
I
P
G
E
F
T
T
M
S
G
R
------------------------
R
L
R
E
A
V
-----
Q
A
E
F
A
S
H
G
----------------------
M
Q
N
M
T
V
V
I
S
G
-----
L
C
N
V
Y
T
H
Y
I
---------------
T
T
Y
E
E
Y
Q
A
Q
R
Y
E
A
A
S
T
I
Y
G
P
H
T
---
L
S
A
Y
I
Q
L
F
R
N
L
-
A
K
A
I
A
T
D
T
-
V
A
N
L
S
R
G
P
E
P
P
F
-----
F
K
Q
----------------
L
I
P
S
I
V
D
R
A
P
K
G
R
T
F
G
D
V
L
Q
P
A
---
K
---
P
E
Y
R
V
G
------------
E
V
A
E
V
I
F
V
G
A
N
P
K
N
S
V
QN
Q
--
T
H
Q
T
F
L
T
V
E
K
Y
-
E
A
--------
T
--
S
T
S
W
Q
I
V
C
N
D
A
S
W
E
T
R
F
-
Y
W
H
K
G
L
L
G
--
L
S
N
A
T
V
E
W
H
----------
I
--
P
D
-
T
A
Q
P
G
I
Y
R
-----------
I
R
Y
F
G
------
H
N
R
K
Q
----A
V
-
I
L
-----------------------
S
F
E
G
T
S
P
A
F
E
V
V
T
----------------------
34
Fugue
42.75
17%
-11
- C3 -
4IUW
16
?
A:
[4-633]
---------------------------------------------------------------
L
P
R
I
Q
D
D
L
Y
L
A
V
N
G
E
W
Q
A
K
T
P
I
P
P
D
-
K
---
S
V
V
S
A
-
D
S
N
L
T
D
-----
D
I
R
Q
K
L
V
A
D
L
S
T
M
T
K
----
T
A
K
T
L
P
L
Q
Y
A
A
R
L
----------
F
A
K
A
N
D
Q
T
R
R
Q
Q
L
G
I
E
P
V
R
--
D
R
I
S
F
L
M
A
L
T
T
L
D
Q
F
R
-
S
A
M
P
K
L
V
A
D
Q
---
Y
V
LP
I
S
P
Y
V
D
A
D
M
H
--
D
A
E
H
N
I
L
N
L
G
G
P
D
T
I
L
P
D
A
A
M
Y
N
Q
ED
A
E
N
A
A
D
L
A
A
W
------
S
Q
M
A
A
A
M
L
A
A
-
V
G
F
--------
S
Q
T
D
Q
T
A
Y
V
E
A
A
K
R
F
D
R
R
L
A
D
Y
V
P
A
N
--
V
D
L
A
V
D
S
T
Y
D
N
P
L
-
S
W
Q
A
F
E
---
D
-
A
A
-
G
Y
L
-
G
I
P
---
Q
A
F
A
---
T
----
Y
M
P
Q
T
P
A
K
V
N
A
V
V
--
P
A
Y
L
P
H
L
S
K
L
L
T
P
D
N
-----
Y
---
S
E
W
H
A
W
M
V
---------
I
N
E
L
L
T
-
C
-
A
T
-------
Y
L
S
D
----------------------
D
L
R
Q
L
A
G
Q
Y
D
--------
R
F
L
A
G
Q
P
E
A
S
-
S
W
T
K
H
A
--------
F
------
G
I
A
N
E
Y
F
-
D
D
V
I
G
Q
Y
Y
G
Q
T
-
Y
F
G
A
D
A
-
K
A
---
D
V
T
A
M
-
V
K
Q
I
L
-
A
Q
Y
R
V
---
Q
-----------
L
---------------------
E
N
N
T
W
L
S
P
A
T
----
K
Q
K
A
M
R
K
----------
L
A
T
M
Q
V
K
M
GYP
A
R
L
F
S
---------------
L
Y
D
H
L
-----
S
-----
V
D
V
----
D
D
D
L
L
T
A
I
L
K
L
--
S
A
Q
T
-
Q
A
F
W
F
K
Q
L
-
G
Q
T
V
D
--
R
N
Q
W
N
M
-----------------------
P
G
H
-
L
V
N
A
S
Y
D
P
L
K
N
---
D
I
T
F
P
A
G
I
LQPPYYSL----------------
K
W
T
R
A
E
-----
N
L
G
G
T
G
A
T
----------------------
I
G
H
--
E
I
S
H
S
-----
F
D
N
N
G
A
L
Y
------------------------
D
E
Y
G
N
L
H
N
W
W
T
P
A
D
---
K
Q
A
F
D
Q
L
V
K
A
M
-
A
A
Q
F
D
G
R
-----------------
D
-
Y
E
----------
G
V
---
K
V
N
--------------
G
T
L
T
V
S
E
---
N
---
M
A
D
N
A
G
------------
M
D
V
A
L
A
L
L
G
D
Q
P
--
D
V
--
K
--
D
L
Q
A
F
F
I
T
Y
A
R
S
W
A
--------
T
--
K
M
R
P
E
R
A
K
T
V
L
R
Q
D
V
H
A
P
A
T
L
R
V
N
V
P
--
V
Q
N
-
F
P
A
W
Y
----------
Q
--
A
F
-
N
V
Q
P
Q
D
G
M
-----------
Y
R
Q
P
Q
------
K
R
L
T
I
W
H
Q
----------------------------------------------------------------
36
Fugue
42.12
18%
-20
- C5 -
4IIB
17
BGL1_ASPAC
A:
[3-841]
-------------------------------------------------------------L
A
F
S
P
P
F
Y
P
S
P
W
A
N
G
Q
G
E
W
A
E
A
Y
Q
R
A
V
-
A
I
V
S
Q
M
T
L
D
E
K
V
N
L
T
T
-----
G
T
G
----
W
E
L
E
K
C
V
G
----
Q
T
G
G
V
-
P
R
L
N
I
G
G
----------
M
C
L
Q
D
S
P
L
G
I
R
D
S
D
Y
N
S
A
F
P
A
G
V
N
V
A
A
T
W
D
K
N
L
A
Y
L
R
-
G
Q
A
M
G
Q
E
F
S
D
K
GI
D
V
----------
Q
L
GP
A
A
G
P
L
G
R
S
P
D
G
----
G
R
N
W
E
G
F
S
P
--
D
-
P
A
L
T
G
V
L
F
------
A
E
T
I
K
G
I
Q
D
A
-
G
V
V
A
T
A
K
H
Y
---
I
L
N
E
Q
E
H
F
R
Q
V
A
E
-
A
A
G
Y
G
F
N
I
S
D
T
--
I
S
S
N
V
D
D
K
T
I
H
E
M
-
Y
L
W
P
F
A
---
D
-
A
V
-
R
A
G
V
G
A
I
M
C
-
S
Y
N
Q
I
N
N
S
YGCQ
N
S
Y
T
L
N
K
L
L
K
A
E
L
GF
Q
G
F
V
M
S
D
W
G
----
A
H
-----
H
---
S
G
V
G
S
A
L
A
GLDMSMPGD
I
T
F
D
S
A
-
T
-
S
F
WG
T
----
N
L
------------------------
T
I
A
V
L
N
G
T
V
P
--------
Q
W
--
R
V
D
D
M
A
V
R
I
M
A
-
A
--------
Y
------
Y
K
V
G
R
D
R
-------
L
Y
Q
P
P
-
N
F
S
S
W
T
-
R
D
---
E
Y
G
F
K
-
Y
F
Y
P
Q
-
E
G
P
Y
E
---
K
VNHFVNVQRNH
S
---------------------
E
V
I
R
K
L
G
A
D
S
TVLL
K
N
N
N
A
L
P
LTGKER
K
V
A
I
L
G
E
D
A
G
S
----
N
S
Y
G
A
NGCSDRGCDNGTLA
M
A
W
G
S
G
-----
T
-----
A
E
F
----
P
Y
---
L
V
T
P
E
Q
--
A
I
Q
A
-
E
V
L
K
H
K
G
------------
S
V
Y
-----------------------
A
I
T
D
N
W
A
L
S
Q
V
E
T
L
A
K
Q
A
S
V
S
L
V
F
V
N
S
D
A
G
EGYISVDGNEGDRNNLTLWK
N
G
D
N
L
I
-----
K
A
A
A
N
N
C
N
N
T
I
V
V
I
H
S
VGPVLVDEWYDHPN
V
T
A
--
I
L
W
A
G
LPGQE
S
G
N
S
L
A
D
V
L
Y
GRVNPGAKSP
F
T
W
G
K
T
R
E
A
Y
G
D
Y
L
V
R
E
L
N
N
G
N
G
A
P
Q
---
D
D
F
S
E
G
V
F
I
D
Y
R
G
F
D
K
R
N
E
T
P
I
Y
E
F
G
H
G
L
S
Y
T
T
F
N
Y
S
G
L
H
I
---------
Q
V
L
NA
V
A
T
E
T
G
A
------
A
P
T
F
G
Q
V
G
N
A
S
---
D
---
Y
V
Y
P
E
G
L
T
R
I
S
KFIYPWL
N
S
T
D
L
K
A
S
S
G
D
P
Y
Y
G
V
--
D
--
T
A
E
H
V
P
E
G
A
T
---
D
--------
G
--
S
P
Q
P
V
L
P
A
G
G
G
S
G
G
N
P
R
-
L
Y
D
E
L
I
R
V
--
S
V
T
V
K
N
T
G
R
----------
V
--
A
G
-
D
A
V
P
Q
L
Y
V
S
LGGPNEPK
V
V
L
R
K
F
D
R
L
T
L
K
P
S
E
E
T
V
W
T
T
T
---
L
T
RRDLSNWDVAAQDWVITSY
P
K
K
V
H
V
G
S
S
S
R
Q
L
P
L
H
A
A
L
P
KVQ----------------
5
PsiBlast_PDB
35.33
26%
-34
- C6 -
2JL1
6
?
A:
[12-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
V
I
Q
H
L
L
-----
K
K
V
----
P
A
---
S
Q
I
I
A
I
V
R
N
V
E
K
A
S
T
L
A
D
Q
G
V
-
E
V
R
H
G
D
Y
N
Q
P
E
S
L
-----------------------
Q
K
A
-
F
A
G
V
S
K
L
L
F
I
S
G
P
H
Y
D
N
T
L
L
I
V
------------------------
Q
H
A
N
V
V
-----
K
A
A
R
D
A
-
G
----------------------
V
K
H
--
I
A
Y
T
G
-----
Y
A
F
A
E
E
S
I
I
---------------
P
L
A
H
V
H
L
A
T
E
Y
A
I
R
T
T
N
I
-
P
Y
T
F
LR
N
A
L
Y
T
D
F
F
V
N
E
-
G
L
----
R
A
S
T
E
S
G
A
I
V
T
N
A
G
S
G
I
V
N
-
S
V
T
R
N
E
L
A
L
A
A
A
T
V
---
L
T
E
E
G
H
E
------
N
K
T
Y
N
L
V
S
N
Q
P
WT
F
D
---
E
L
A
Q
I
L
------------
S
E
V
S
G
K
K
V
V
H
Q
P
V
S
-
F
--
E
--
E
E
K
N
F
L
--
V
N
A
G
V
P
--------
E
--
P
F
T
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
-
A
S
K
T
S
D
D
L
--
Q
K
L
I
G
S
L
T
P
----------
L
--
K
E
-
T
V
K
Q
A
L
K
M
----------------------------------------------------------------------------------------------
21
HHSearch
35.20
12%
-10
- C6 -
2P9R
-
A2MG_HUMAN
A:
[113-187]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
Y
K
P
G
------------
Q
T
V
K
F
R
V
V
S
M
D
E
N
F
H
P
-----
L
N
E
L
I
P
L
V
Y
I
Q
D
---------------------
P
K
G
--
N
R
I
A
-
Q
W
Q
S
F
Q
L
E
--
G
G
L
K
Q
F
S
F
P
----------
L
--
S
S
-
E
P
F
Q
G
S
Y
K
-----------
V
V
V
Q
K
------
K
-----------------------------------------------------------------------
4
PsiBlast_PDB
34.74
26%
-40
- C6 -
2VRB
1
?
A:
[12-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
V
I
Q
H
L
L
-----
K
K
V
----
P
A
---
S
Q
I
I
A
I
V
R
N
V
E
K
A
S
T
L
A
D
Q
G
V
-
E
V
R
H
G
D
Y
N
Q
P
E
S
L
-----------------------
Q
K
A
-
F
A
G
V
S
K
L
L
F
I
S
G
P
H
Y
D
N
T
L
L
I
V
------------------------
Q
H
A
N
V
V
-----
K
A
A
R
D
A
-
G
----------------------
V
K
H
--
I
A
Y
T
G
-----
Y
A
F
A
E
E
S
I
I
---------------
P
L
A
H
V
H
L
A
T
E
Y
A
I
R
T
T
N
I
-
P
Y
T
F
LR
N
A
L
Y
T
D
F
F
V
N
E
-
G
L
----
R
A
S
T
E
S
G
A
I
V
T
N
A
G
S
G
I
V
N
-
S
V
T
R
N
E
L
A
L
A
A
A
T
V
---
L
T
E
E
G
H
E
------
N
K
T
Y
N
L
V
S
N
Q
P
WT
F
D
---
E
L
A
Q
I
L
------------
S
E
V
S
G
K
K
V
V
H
Q
P
V
S
-
F
--
E
--
E
E
K
N
F
L
--
V
N
A
G
V
P
--------
E
--
P
F
A
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
-
A
S
K
T
S
D
D
L
--
Q
K
L
I
G
S
L
T
P
----------
L
--
K
E
-
T
V
K
Q
A
L
------------------------------------------------------------------------------------------------
35
Fugue
34.40
10%
-19
- C4 -
3PSF
-
SPT6_YEAST
A:
[298-1248]
D
I
Y
D
L
E
D
L
K
K
N
LMT
E
G
D
M
K
I
R
K
TDIP
E
R
Y
Q
E
L
R
A
GITDYGNMS
S
E
D
Q
E
L
E
R
N
W
I
A
E
K
I
S
V
D
K
N
F
D
A
N
Y
D
L
T
E
F
K
E
A
I
G
N
A
I
K
F
I
T
K
E
N
L
E
V
P
F
I
Y
A
Y
R
-
R
N
Y
I
S
S
-----
R
E
K
D
G
F
L
L
---
T
E
D
D
----
L
W
D
I
V
S
L
D
I
E
F
H
S
----------
L
V
N
K
K
D
Y
V
Q
R
F
Y
A
E
L
H
I
D
D
--
P
I
V
T
E
Y
F
K
N
Q
N
S
L
Q
D
I
-
Y
D
Y
L
E
F
K
Y
A
N
---
E
I
----------
N
E
--
M
S
Y
E
K
F
K
A
S
P
L
----
Y
Q
A
V
S
D
I
G
I
--
S
A
E
D
V
G
E
N
I
S
S
QHQIH
P
P
V
D
H
P
S
S
K
P
-
V
E
V
I
E
S
I
L
N
A
N
S
G
D
L
Q
T
K
L
A
I
D
T
V
Q
-
K
Y
Y
S
L
E
L
S
K
N
T
--
K
I
R
E
K
V
R
S
D
F
S
K
Y
-
Y
L
A
D
V
V
L
T
A
K
-
G
K
-
K
E
I
Q
K
G
S
---
L
Y
E
D
I
K
Y
A
----
I
N
R
T
P
M
H
F
R
R
D
P
D
--
V
F
L
K
M
V
E
A
E
S
-
L
N
L
L
-----
S
---
V
K
L
H
M
S
S
Q
---------
A
Q
Y
I
E
H
-
L
-
F
Q
-------
I
A
------------------------
L
E
T
T
N
T
S
D
I
A
--------
I
E
W
N
N
F
R
K
L
A
F
N
Q
A
M
D
K
--------
I
F
Q
D
I
S
Q
E
V
K
D
N
L
T
-
K
N
C
Q
K
L
V
A
K
T
V
-
R
H
K
F
M
T
-
K
L
D
QA
P
F
I
P
N
-
V
R
D
P
K
I
P
K
I
L
S
---
L
-----------
T
CGQGRFGA
D
A
I
I
A
V
Y
V
N
RKGD
F
I
R
D
Y
K
I
V
D
N
----
P
F
D
K
T
N
P
----------
E
K
F
E
D
T
L
----
D
N
I
I
Q
---------------
S
C
Q
P
N
-----
A
-----
I
G
I
N
GPN
P
K
---
T
Q
K
F
Y
K
--
R
L
Q
E
-
V
L
H
K
K
Q
I
V
-
D
S
R
G
H
--
T
I
P
I
I
Y
V
ED
E
V
A
I
R
Y
Q
N
S
E
R
A
A
Q
E
F
PNKP
P
L
V
-
K
Y
C
I
A
L
A
R
Y
M
H
S
P
L
L
E
Y
A
N
L
T
S
------------------------
E
E
V
R
S
L
SIHPH
Q
N
L
L
S
S
E
Q
----------------------
L
S
W
--
A
L
E
T
A
-----
F
V
D
I
V
N
L
V
S
---------------
V
E
V
N
K
A
T
D
N
N
Y
Y
A
S
A
L
K
Y
I
S
G
F
---
G
K
R
K
A
I
D
F
L
Q
S
-
L
Q
R
L
N
E
P
L
L
A
R
Q
Q
L
I
T
H
N
I
L
H
K
T
I
F
-
M
N
S
---------
A
G
---
F
L
Y
I
S
W
N
------
E
D
L
E
H
D
Q
L
D
S
T
---
R
IHP
E
D
Y
H
L
A
------------
T
K
V
A
A
D
A
L
-
E
Y
D
P
D
T
I
--
A
--
E
K
E
E
Q
G
T
M
S
E
F
I
E
L
--------
L
--
R
E
D
P
D
R
R
A
K
L
E
S
L
N
L
E
S
-
Y
A
E
E
L
E
K
N
TG
L
R
K
L
N
N
L
N
T
----------
I
--
V
L
-
E
L
L
D
G
F
E
E
-----------
L
R
N
D
F
------
H
P
L
Q
G
D
E
I
F
---
Q
S
-----------------------
L
T
G
E
S
S
K
D
P
S
I
W
D
L
K
Q
E
L
E
D
A
E
E
E
R
K
L
M
M
A
E
A
R
AK
33
Fugue
31.14
14%
-23
- C2 -
4L8N
3
?
A:
[6-457]
------------------------------------------------------------------------
N
T
S
I
C
R
L
G
F
T
Y
D
I
S
Q
S
-
K
---
N
W
G
N
N
-
K
P
V
I
K
S
I
I
P
YS
S
A
E
Q
A
G
I
K
K
Y
D
V
I
E
E
INGV
P
V
T
E
V
S
V
D
E
I
P
Q
L
L
N
PAGRN
D
V
L
L
T
I
S
N
L
S
S
P
S
K
Q
V
L
V
K
K
D
C
--
K
K
S
N
A
I
T
E
D
Q
L
A
S
A
Y
A
M
Y
S
L
E
T
T
N
E
Q
E
---
F
V
----------
C
P
--
F
K
T
T
V
T
S
D
G
V
D
----
F
G
N
F
K
T
F
A
F
--
S
T
I
D
E
N
N
R
K
L
------
E
T
V
I
N
E
C
I
E
N
E
L
T
K
K
G
L
T
V
D
I
A
K
P
D
L
L
I
Q
T
F
Y
F
F
D
K
-
N
P
N
Y
L
G
--
A
N
E
--
K
E
P
T
Y
R
Y
N
F
S
H
S
K
M
E
K
F
P
F
L
---
N
-
Y
A
-
A
A
E
A
E
A
----------
E
Y
----
L
L
Q
F
G
I
R
I
I
D
Q
K
D
--
I
P
-
G
R
V
L
W
E
C
-
E
A
N
E
-----
L
L
E
D
S
Y
R
L
D
E
Y
A
---------
R
V
H
V
P
L
M
C
M
Q
Y
PYTKYG
R
N
V
------------------------
P
F
K
V
S
K
K
T
Y
N
Y
TG
I
S
Y
D
I
D
K
L
D
Q
V
V
D
V
D
R
N
S
P
A
Y
A
A
GIRPRDI
I
------
E
K
I
G
R
H
K
M
D
H
S
A
E
E
F
S
S
A
Y
K
R
F
I
T
N
T
M
Q
Y
---
R
D
P
K
T
M
F
T
D
A
N
-
G
F
K
Y
C
M
F
W
D
-----------
V
---------------------
F
K
Y
P
Q
I
A
D
A
S
----
Q
S
-------------------
S
D
Y
----
L
P
A
F
S
---------------
Y
L
Y
Y
F
-----
A
-----
P
Y
I
----
N
P
---
S
G
N
N
A
C
--
T
F
N
I
-
K
R
G
K
T
K
L
E
-
V
I
I
R
P
--
T
I
R
S
E
V
-----------------------
T
V
E
-
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
25.74
22%
70
- C6 -
2ZZ8
-
?
A:
[90-199]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
G
------------
D
L
V
S
D
A
F
K
A
A
T
P
E
E
K
S
--
M
PH
W
F
D
T
W
I
R
V
E
R
M
S
-
A
IMPDQ
I
A
K
A
A
K
A
K
P
V
Q
-------
G
D
D
T
Y
-
K
E
E
R
H
N
K
Y
--
N
S
L
T
R
I
K
I
P
NPPKSFDDLK
N
ID
T
K
K
L
L
V
R
G
L
Y
R
-----------
I
S
F
T
T
------
Y
K
P
G
E
V
K
G
S
---
F
V
-----------------------
A
S
V
G
L
L
F
P
P
G
I
P
G
V
S
P
-------------------
6
PsiBlast_PDB
24.38
24%
7
- C6 -
2VRC
-
?
D:
[12-203]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
L
-----
V
IQHLM
A
A
V
----
P
A
---
S
Q
I
I
A
I
VR
N
V
E
K
A
S
T
L
A
D
Q
G
V
-
E
V
R
H
G
DY
N
Q
P
E
S
L
-----------------------
Q
K
A
-
F
A
G
V
S
K
L
L
F
I
S
G
P
H
Y
D
N
T
L
L
I
V
------------------------
Q
H
A
N
V
V
-----
K
A
A
R
D
A
-
G
----------------------
V
K
H
--
I
A
Y
T
G
-----
Y
A
F
A
E
E
S
I
I
---------------
P
L
A
H
V
H
L
A
T
E
Y
A
T
R
T
T
N
I
-
P
Y
T
FLR
N
A
L
Y
T
D
F
F
V
N
E
-
G
L
----
R
A
S
T
E
S
G
A
I
V
T
N
A
G
S
G
I
V
N
-
S
V
T
RNELALAAA
T
V
---
L
T
E
E
G
H
E
------
N
K
T
Y
N
L
V
S
N
Q
P
---
W
---
T
F
D
E
L
A
------------
Q
I
L
S
E
V
S
G
K
K
V
V
H
Q
P
V
--
S
--
F
E
E
E
K
N
F
M
V
N
A
G
V
P
--------
E
--
P
F
A
E
I
T
A
A
I
Y
D
A
I
S
K
G
E
-
A
S
K
T
S
D
D
L
--
Q
K
L
I
G
S
L
T
P
----------
L
--
K
E
-
T
V
K
Q
A
L
------------------------------------------------------------------------------------------------
22
HHSearch
19.97
14%
31
* C6 *
3JAM
-
?
Y:
[24-72]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
D
V
L
H
--
P
N
R
A
N
V
S
K
D
E
L
R
E
K
L
A
-
E
A
Y
K
--
A
E
K
D
---
A
V
----------
S
V
--
F
G
F
R
T
Q
Y
G
G
G
K
----
S
T
G
F
G
L
V
Y
N
--
S
V
A
D
A
K
K
F
E
P
------
A
Y
R
L
V
R
Y
G
L
A
-
E
K
V
E
K
A
S
R
Q
Q
R
K
Q
R
K
N
R
G
K
K
I
F
G
T
G
-
K
S
I
A
K
K
A
A
R
R
N
--
A
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
18.23
24%
42
- C6 -
1EQJ
3
GPMI_GEOSE
A:
[389-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
-
Y
D
A
I
I
L
N
Y
A
N
P
--
D
M
V
G
H
S
G
K
L
E
P
T
I
-
K
A
V
E
A
V
---
D
E
C
L
-
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
----
D
H
G
N
A
D
E
V
L
T
P
D
G
--
K
P
Q
T
A
H
T
T
N
P
-
V
P
V
I
-----
V
---
T
K
K
G
I
K
L
R
---------
D
G
G
I
L
G
-
D
-
L
A
-------
P
T
------------------------
M
L
D
L
L
G
L
P
Q
P
--------
K
E
M
T
G
K
S
L
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
17.57
24%
46
- C6 -
1EJJ
3
GPMI_GEOSE
A:
[389-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
-
Y
D
A
I
I
L
N
Y
A
N
P
--
D
M
V
G
H
S
G
K
L
E
P
T
I
-
K
A
V
E
A
V
---
D
E
C
L
-
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
----
D
H
G
N
A
D
E
V
L
T
P
D
G
--
K
P
Q
T
A
H
T
T
N
P
-
V
P
V
I
-----
V
---
T
K
K
G
I
K
L
R
---------
D
G
G
I
L
G
-
D
-
L
A
-------
P
T
------------------------
M
L
D
L
L
G
L
P
Q
P
--------
K
E
M
T
G
K
S
L
I
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
17.29
24%
52
- C6 -
1O99
3
GPMI_GEOSE
A:
[389-457]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
K
-
Y
D
A
I
I
L
N
Y
A
N
P
--
D
M
V
G
H
S
G
K
L
E
P
T
I
-
K
A
V
E
A
V
---
D
-
E
C
L
G
K
V
V
D
A
I
L
A
K
G
G
I
A
I
I
T
A
----
D
H
G
N
A
D
E
V
L
T
P
D
G
--
K
P
Q
T
A
H
T
T
N
P
-
V
P
V
I
-----
V
---
T
K
K
G
I
K
L
R
---------
D
G
G
I
L
G
-
D
-
L
A
-------
P
T
------------------------
M
L
D
L
L
G
L
P
Q
P
--------
K
E
M
T
G
K
S
L
I
V
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------