@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3584: (2016-02-18 )
MSQAHTPSAPLAEVYDVAVVGGGINGVGIAADAAGRGLSVFLCEQHDLAQHTSSASSKLIHGGLRYLEHYEFRLVREALAEREVLLAKAPHIVKPLRFVLPHRPHLRPAWMIRAGLFLYDHLGKREKLPASRGLRFTGSSPLKAEIRRGFEYSDCAVDDARLVVLNAISAREHGAHVHTRTRCVSARRSKGLWHLHLERSDGSLYSIRARALVNAAGPWVARFIQDDLKQKSPYGIRLIQGSHIIVPKLYEGEHAYILQNEDRRIVFAIPYLDRFTMIGTTDREYQGDPAKVAISEEETAYLLQVVNAHFKQQLAAADILHSFAGVRPLCDDESDEPSAITRDYTLSLSAGNGEPPLLSVFGGKLTTYRKLAESALTQLQPFFANLGPAWTAKAPLPGGEQMQSVEALTEQLANRYAWLDRELALRWARTYGTRVWRLLDGVNGEADLGEHLGGGLYAREVDYLCKHEWAQDAEDILWRRSKLGLFLSPSQQVRLGQYLQSEHPHRPRVHAA
Atome Classification :
(20 SA)
.........10........20........30....-....40.....-.-..50-.........60.......-.70........80........90----..-.......100---...-.-.---...110........120......-.130......---.140--.--------------.-.-.--------...150----........160.--......170.......180.......-190---------------........200---........210.......220......-.230-.......240....--...250-.----.-----------..-..-.----.260.--......---..270-..-.-....280.....--.-.290--.--.......-.300.......310-...--....320..--.....------------330.......340.......350-.-....-...360---.---......370.......-----380....-----...390.......--400..-.-.....410.--..--....--420.......430.......440.......450..-......460.......470.......480....----------------------...490.......500.......510
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSQAHTPSA
P
L
A
E
V
Y
D
V
A
V
VGGGIN
G
V
G
I
AADAAG-R
G
L
S
V
F
L
CEQH-
D
-
L
A
Q
--HTSSA
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
R
E
A
L
AE
R
E
V
L
L
AKA
P
-----
H
I
-
V
K
P
L
R
F
VLP----HRP-H-L---
R
P
A
W
-
M
I
R
A
G
L
F
L
Y
D
HLGKREKL-PASRG
L
R
FTG---SS
P
L
--
K
--------------
A
-
E
-
I
--------
R
RGF-E----YSDCAVDD
A
R
L
V
--
V
L
N
A
ISAREHGAHV
H
T
R
T
R
C
V
S
A
RRS-K
G
----------------
L
W
H
L
H
L
ERS-D---G
S
L
Y
S
I
R
A
R
A
L
VNAA
G
P
W
V
A
R
F
I
Q
D
D
L
-KQKS-PY
G
I
R
L
IQG
S
H
I
I
V
--
P
K
LY-E-G----
E
-----------
H
A
-
Y
I
-
L
----QN--E--D
R
R
I
V
F
---AIPYL-D
R
-
F
-
T
MIGTTDREYQG--D-P
A
----
K
--
V
A
ISE
E
E
-
T
A
Y
L
L
Q
V
V
N
A
H
F
K
Q
-
Q
L
A
--
A
A
D
I
L
H
S
F
A--GVRPL------------CDDESDEPS
A
I
T
R
D
Y
T
L
S
LSAG--N-GEP
P
-
L
L
S
VFG---G---
K
L
T
T
Y
R
K
L
A
E
S
A
L
T
Q
L
-----
Q
P
F
F
A
NL-----GPAWTAKAPLPG
G
--
E
-
Q
M
Q
-
S
-
V
E
A
L
T
E
Q
L
A
--
N
R
--
Y
A
W
L
--
D
R
E
L
A
L
R
W
A
R
T
Y
G
T
R
V
W
R
L
L
DGVNGE
A
D
L
G
E
-HLG-GG
L
Y
A
R
E
V
D
Y
L
C
K
H
E
W
A
Q
D
A
E
D
I
L
W
R
R
SKL
G
L
F
----------------------LSPS
Q
Q
V
R
L
G
Q
Y
L
Q
SEHPHRPRVHAA
2
PsiBlast_PDB
93.37
60%
-94
- C1 -
2R45
27
GLPD_ECOLI
A:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
23
PsiBlast_CBE
92.44
60%
-94
- C1 -
2R45
15
GLPD_ECOLI
B:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
3
PsiBlast_PDB
92.37
60%
-92
- C1 -
2R46
23
GLPD_ECOLI
A:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
4
PsiBlast_PDB
92.12
60%
-93
- C1 -
2R4E
20
GLPD_ECOLI
A:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
5
PsiBlast_PDB
91.99
60%
-93
- C1 -
2R4J
22
GLPD_ECOLI
A:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
22
PsiBlast_CBE
91.90
60%
-92
- C1 -
2R46
14
GLPD_ECOLI
B:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
1
PsiBlast_PDB
91.77
60%
-93
* C1 *
2QCU
24
GLPD_ECOLI
A:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
24
PsiBlast_CBE
91.75
60%
-91
- C1 -
2QCU
12
GLPD_ECOLI
B:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
21
PsiBlast_CBE
91.66
60%
-92
- C1 -
2R4E
18
GLPD_ECOLI
B:
[27-489]
--------------------------------------
L
S
V
L
M
L
E
A
Q
-
D
-
L
A
C
--
A
T
S
S
A
S
S
K
L
I
H
G
G
L
R
Y
L
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
----
H
R
P
-
H
-
L
---
R
P
A
W
-
M
I
R
I
G
L
F
M
Y
D
H
L
G
K
R
T
S
L
-
P
G
S
T
G
L
R
F
G
A
---
N
S
V
L
--
K
--------------
P
-
E
-
I
--------
K
R
G
F
-
E
----
Y
S
D
C
W
V
D
D
A
R
L
V
--
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
A
T
S
A
R
R
E
-
N
G
----------------
L
W
I
V
E
A
E
D
I
-
D
T--
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
F
F
D
D
G
M
-
H
L
P
S
-
P
Y
G
I
R
L
I
K
G
S
H
I
V
V
--
P
R
V
H
-
T
-
Q
----
K
-----------
Q
A
-
Y
I
-
L
----
Q
N
--
E
--
D
K
R
I
V
F
---
V
I
P
W
M
-
D
E
-
F
-
S
I
I
G
T
T
D
V
E
Y
K
G
--
D
-
P
K
----
A
--
V
K
I
E
E
S
E
-
I
N
Y
L
L
N
V
Y
N
T
H
F
K
K
-
Q
L
S
--
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
------------
C
D
D
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
E
--
N
-
G
K
A
P
-
L
L
S
V
F
G
---
G
---
K
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
-----
T
P
Y
Y
Q
G
I
-----
G
P
A
W
T
K
E
S
V
L
P
G
G
--
A
-
I
E
G
-
D
-
R
D
D
Y
A
A
R
L
R
--
R
R
--
Y
P
F
L
--
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
D
L
G
E
-
D
F
G
-
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
K
Q
G
M
W
----------------------
L
N
A
D
Q
Q
S
R
V
S
Q
W
L
-------------
49
HHSearch
67.94
29%
-75
- C1 -
2RGH
2
?
A:
[29-569]
----------
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
-
S
G
I
K
T
G
L
I
E
M
Q
-
D
-
F
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
----
I
Y
E
-
D
E
G
ATT
F
N
M
F
-
S
V
K
V
A
M
D
L
Y
D
K
L
A
N
V
T
G
T
K
Y
E
N
Y
T
L
T
P
E
E
V
L
E
R
E
P
F
--
L
K-------------
K
-
E
G
L
--------
K
G
A
G
-
V
----
Y
L
D
F
R
N
N
D
A
R
L
V
--
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
L
Y
E
-
G
D
Q---------------
I
V
G
V
K
A
R
D
L
L
T
---
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-
T
R
P
V
-
S
P
K
M
R
P
T
K
G
I
H
L
V
V
--
D
A
K
K
-
L
-
P
V---
P
-----------
Q
P
-
T
Y
-
F
----
D
T
GK
Q
--
D
G
R
M
V
F
---
A
I
P
R
E
--
N
-
K
-
T
Y
F
G
T
T
D
T
D
Y
Q
G
--
D
-
F
T
----
D
--
P
K
V
T
Q
E
D
-
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
--
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
------------
L
I
G
-----------
S
S
L
E
R
E
P
-------
D
G
-
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
-----
R
Q
L
L
K
E
E
YG
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
--
N
-
F
D
P
T
K
-
L
E
E
T
V
T
E
L
A
K
E
G
V
--
A
A
G
L
--
E
E
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
M
A
P
Y
---
P
G
L
-
S
L
A
E
S
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
ERDQLDEI
K
Q
P
V
I
D
A
I
A
E
Y
F
GW
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
L
K
G
7
PsiBlast_PDB
63.20
30%
-88
- C1 -
2RGH
2
?
A:
[55-477]
-------------------------------------
G
I
K
T
G
L
I
E
M
Q
-
D
-
F
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
ED
E
G
A
-
T
-
T
---
F
N
M
F
-
S
V
K
V
A
M
D
L
Y
D
------
K
L
-
A
N
V
T
G
T
K
Y
E
N
---
Y
T
L
T
--
P
--------------
E
-
E
-
V
L
E
R
EPFLK
K
E
G
L
-
K
G
A
G
V
Y
L
D
F
R
N
N
D
A
R
L
V
--
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
-
L
Y
-
E
G
----------------
D
Q
I
V
G
V
K
A
R
-
D
LLT
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-
T
R
P
V
-
S
P
K
M
R
P
T
K
G
I
H
L
V
V
DA
K
K
L
P
-
V
-
P
----
Q
-----------
P
T
-
Y
F
D
T
----
G
K
--
Q
--
D
G
R
M
V
F
---
A
I
P
R
E
-
N
K
---
T
Y
F
G
T
T
D
T
D
Y
Q
G
--
D
-
F
T
----
D
--
P
K
V
T
Q
E
D
-
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
--
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
------------
L
I
G
-----------
S
S
L
E
R
--------
E
P
D
G
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
-----
K
E
I
D
S
K
K
Y
Q
I
S
G
G
--
N
F
D
P
T
-
K
-
L
E
E
T
V
T
E
L
A
--
K
E
G
V
A
A
G
L
--
E
E
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
------------------------------------------------------------------------------------------------
48
HHSearch
61.13
30%
-72
- C1 -
3DA1
1
?
A:
[14-543]
---------
M
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
-
R
G
I
Q
T
G
L
V
E
M
N
-
D
-
F
A
S
--
G
T
S
S
R
S
T
K
L
V
H
G
----------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
P
----
I
F
K
---------------------------------
R
Y
M
L
N
E
K
Q
T
L
E
K
E
P
L
--
L
R-------------
K
E
N
-
L
--------
K
G
G
G
-
I
----
Y
V
E
Y
R
T
D
D
A
R
L
T
--
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
-
Q
G
K---------------
V
V
G
V
V
A
K
D
R
L
T
---
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
K
D
R
-
S
K
-
H
-
G
K
Y
L
K
L
S
K
G
V
H
L
V
V
--
D
Q
S
R
-
F
-
P
L---
R
-----------
Q
A
-
V
Y
-
F
----
D
T
E-
S
--
D
G
R
M
I
F
---
A
I
P
R
--
E
G
-
K
-
T
Y
I
G
T
T
D
T
F
Y
D
K
--
D
-
I
A
----
S
--
P
R
M
T
V
E
D
-
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
--
L
R
LT
A
D
D
V
E
S
S
W
A
--
G
L
R
P
L
------------
I
H
E
-----------
D
E
I
F
F
S
D
-------
S
G
-
L
I
S
I
A
G
---
G
---
K
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
-----
A
Q
G
L
N
V
N
-----
E
P
C
T
T
A
A
I
R
L
S
G
G
--
L
-
A
E
G
A
Q
G
F
P
R
F
L
D
E
A
S
R
K
G
A
--
K
L
G
F
--
D
A
D
E
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
E
E
A
E
H
Y
G
L
-
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
SW
T
E
E
E
K
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
V
D
-----
8
PsiBlast_PDB
60.40
27%
-89
- C1 -
2RGO
1
?
A:
[41-514]
-------------------------------------
G
I
K
T
G
L
I
E
M
Q
-
D
-
F
A
E
--
G
T
S
S
R
S
T
K
L
V
H
G
G
I
R
Y
L
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
ED
E
G
A
-
T
-
T
---
F
N
M
F
-
S
V
K
V
A
M
D
L
Y
D
------
K
L
-
A
N
V
T
G
T
K
Y
E
N
---
Y
T
L
T
--
P
--------------
E
-
E
-
V
L
E
R
EPFLK
K
E
G
L
-
K
G
A
G
V
Y
L
D
F
R
N
N
D
A
R
L
V
--
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
A
V
G
F
-
L
Y
-
E
G
----------------
D
Q
I
V
G
V
K
A
R
-
D
LLT
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-
T
R
P
V
-
S
P
K
M
R
P
T
K
G
I
H
L
V
V
DA
K
K
L
P
-
V
-
P
----
Q
-----------
P
T
-
Y
F
D
T
----
G
K
--
Q
--
D
G
R
M
V
F
---
A
I
P
R
E
-
N
K
---
T
Y
F
G
T
T
D
T
D
Y
Q
G
--
D
-
F
T
----
D
--
P
K
V
T
Q
E
D
-
V
D
Y
L
L
D
V
I
N
H
R
Y
P
E
A
N
I
T
--
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
LIGNSGSDYNGG---------
T
I
S
R
G
S
S
L
E
R
--------
E
P
D
G
L
L
T
L
S
G
---
G
---
K
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
-----
K
E
I
D
S
K
K
Y
Q
I
S
G
G
--
N
F
D
P
T
-
K
-
L
E
E
T
V
T
E
L
A
--
K
E
G
V
A
A
G
L
--
E
E
E
D
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
57.30
30%
-72
- C1 -
3DA1
1
?
A:
[36-503]
-------------------------------
D
A
Q
V
-
R
G
I
Q
T
G
L
V
E
M
N
-
D
-
F
A
S
--
G
T
S
S
R
S
T
K
L
V
H
G
----------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
P
I
---
F
K
---------------------------
R
Y
M
L
-
N
E
K
Q
T
L
E
------
K
E
P
L
LR
K
--------------
E
-
N
-
L
--------
K
G
G
G
-
I
----
Y
V
E
Y
R
T
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
V
E
S
F
I
Y
D
Q
G
-
K
V
----------------
V
G
V
V
A
K
D
R
L
-
T
---
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
K
D
R
-
S
K
H
G
-
K
Y
-
L
K
L
S
K
G
V
H
L
V
V
D
Q
S
R
F
P
-
L
-
R
----
Q
-----------
A
V
-
Y
F
-
D
----
T
E
--
S
--
D
G
R
M
I
F
---
A
I
P
R
E
-
G
K
---
T
Y
I
G
T
T
D
T
F
Y
D
K
--
D
-
I
A
----
S
--
P
R
M
T
V
E
D
-
R
D
Y
I
L
A
A
A
N
Y
M
F
P
S
L
R
L
T
--
A
D
D
V
E
S
S
W
A
--
G
L
R
P
L
------------
I
H
E
-----------
D
E
I
F
F
S
-------
D
S
G
-
L
I
S
I
A
G
---
G
---
K
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
-----
A
Q
G
L
N
V
N
-----
E
P
C
T
T
A
A
I
R
L
S
G
G
LA
E
-
G
A
Q
-
G
-
F
P
R
F
L
D
E
A
S
--
R
K
--
G
A
K
L
GF
D
A
D
E
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
E
E
A
E
-
H
Y
G
L
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
-
A
L
F
----------------------
F
N
I
S
----------------------
64
HHSearch
53.92
17%
-80
- C1 -
2OLN
3
?
A:
[3-375]
------------
E
S
Y
D
V
V
V
V
G
G
G
P
V
G
L
A
T
A
W
Q
V
A
E
-
R
G
H
R
V
L
V
L
E
R
H
-
T
-
F
F
N
--
E
N
G
G
T
S
G
A
E
R
H
W
R
L
Q
Y
T
Q
-
E
D
L
F
R
L
T
L
E
T
L
P
L
W
R
A
L
E
S
R
C
E
R----
R
L
-
I
H
E
I
G
S
L
W
F
----
G
D
T
-
D
-
V
---
V
T
N
E
G
Q
I
S
G
T
A
A
M
M
D
K
L
----
S
--
V
R
Y
E
W
L
K
A
T
D
I
E
R
R
F
G
F
--
R
GL------------
P
-
R
-
D
--------
Y
E
G
F
L
Q
----
P
D
G
G
T
I
D
V
R
G
T
L
--
A
A
L
F
T
L
A
Q
A
A
G
A
T
L
R
A
G
E
T
V
T
E
L
V
P
D
-
A
D
----------------
G
V
S
V
T
T
D
-------
R
--
G
T
Y
R
A
G
K
V
V
L
A
C
G
P
Y
T
N
D
L
L
E
P
L
G
-
A
----
R
L
A
Y
S
V
Y
E
M
A
I
A
A
Y
--
R
Q
A
T
P
V
-
T
----
E
-----------
A
P
-
F
W
-
F
A
F
Q
Q
P
T
P-
Q
--
D
T
N
L
F
Y
G
FG
H
N
P
W
A
-
P
G
-
E
F
V
R
C
G
P
D
F
E
V
D
P
L
--
D
H
P
S
----
A
AT
G
V
A
D
R
R
Q
-
M
D
R
L
S
G
W
L
R
D
H
L
P
T
--
V
D
--
P
-
D
P
V
R
T
S
T
C
L
A
V
L
P
T
------------
D
P
E
R
Q
F
---------
F
L
G
T
A
R
D
LM
T
-
H
G
E
K
-
L
V
-
V
Y
G
AG-
W
---
A
F
K
F
V
P
L
F
G
R
I
C
A
D
L
A
-----
V
E
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
50.75
18%
-75
- C1 -
3DME
4
?
A:
[3-368]
------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
-
G
G
H
E
V
L
V
A
E
A
A
E
G
-
I
G
T
--
G
T
S
S
R
N
S
E
V
I
H
A
G
I
Y
Y
P
A
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
R
G
-----
V
P
-
H
Q
R
L
G
K
L
I
V
----
A
T
S
D
A
-
E
---
A
S
Q
L
------
D
S
I
A
R
R
A
G
-
A
N
G
V
-
D
D
L
Q
H
I
D
G
A
A
A
R
R
L
E
P
A
--
L
----------------
H
-
C
--------
T
A
A
L
-
V
S
---
P
S
T
G
I
V
D
S
H
A
L
M
--
L
A
Y
Q
G
D
A
E
S
D
G
A
Q
L
V
F
H
T
P
L
I
A
G
R
V
R
P
E
G
----------------
G
F
E
L
D
F
G
---
G
---
A
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
L
H
A
P
G
L
A
R
R
I
E
G
I
P
R
D
S
I
P
P
E
Y
L
C
K
G
S
Y
F
T
L
--
A
G
R
A
-
P
-
F
----
S
-----------
R
--
L
I
-
Y
----
P
V
--
P
QH
A
G
L
G
V
H
---
L
T
L
D
L
-
G
G
-
Q
-
A
K
F
G
P
D
T
E
W
I
A
-----
T
E
----
D
--
Y
T
L
D
P
R
R
-
A
D
V
F
Y
A
A
V
R
S
Y
W
P
--
A
L
P
--
D
G
A
L
A
P
G
Y
T
--
G
I
R
P
K
------------
I
S
G
P
H
----
E
P
A
A
D
F
A
I
A
G
P
-
A
--
S
H
G
V
A
G
-
L
V
N
L
Y
G
---
I
ESP
G
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
-----
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
50.75
14%
-82
- C1 -
1RYI
2
GLOX_BACSU
A:
[14-362]
----------
M
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
-
E
N
K
N
T
A
L
F
E
S
G
-
T
-
M
G
G
--
R
T
T
S
A
A
A
G
M
L
G
A
H
A
E
C
E
E
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
SGV
D
I
R
Q
H
N
G
G
M
F
K
L
----
A
F
S
E
E
-
D
---
V
L
Q
L
----------
R
Q
M
---
D
D
L
-
D
S
V
S
W
Y
S
K
E
E
V
L
E
K
E
P
Y
--
A
S-------------
G
-
D
-
I
--------
F
G
A
S
F
I
----
Q
D
D
V
H
V
E
P
Y
F
V
C
--
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
V
L
H
V
E
R
D
-
G
E
----------------
A
L
F
I
K
T
P
-------
S
--
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
----
L
-
N
N
A
F
L
P
V
K
G
E
C
L
S
V
--
W
N
D
D
-
I
-
P
----
L
-----------
T
K
-
T
L
-
Y
------------
H
D
H
C
Y
---
I
V
P
R
K
-
S
G
-
R
-
L
V
V
G
A
T
M
K
P
G
D
W
----------
S
--
E
T
P
D
L
G
G
-
L
E
S
V
M
K
K
A
K
T
M
L
P
--
A
I
Q
--
N
M
K
V
D
R
F
W
A
--
G
L
R
P
G
------------
T
K
D
G
K
P
---------
Y
I
G
R
H
----
P
-
E
D
S
R
-
I
L
F
A
A
G
HFR
N
---
G
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
-----
M
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
49.56
14%
-80
- C1 -
2GF3
6
MSOX_BACB0
A:
[2-364]
------------
T
H
F
D
V
I
V
V
G
A
G
S
M
G
M
A
A
G
Y
Q
L
A
K
-
Q
G
V
K
T
L
L
V
D
A
F
-
D
-
P
P
H
TN
G
S
H
H
G
D
T
R
I
I
R
H
A
Y
G
E
-
G
-
R
E
Y
V
P
L
A
L
R
S
Q
E
L
W
Y
E
L
E
K
E
T
H
H----
K
I
-
F
T
K
T
G
V
L
V
F
----
G
P
K
-
G
-
E
---
S
A
F
V
------
A
E
T
M
E
A
A
K
-
E
H
S
L
--
T
V
D
L
L
E
G
D
E
I
N
K
R
W
P
G
--
I
T
V
------------
P
-
E
-
N
--------
Y
N
A
I
F
E
----
P
N
S
G
V
L
F
S
E
N
C
I
--
R
A
Y
R
E
L
A
E
A
R
G
A
K
V
L
T
H
T
R
V
E
D
F
D
I
S
-
P
D
----------------
S
V
K
I
E
T
A
---
N
------
G
S
Y
T
A
D
K
L
I
V
S
M
G
A
W
N
S
K
L
L
S
K
L
N
----
L
-
D
I
P
L
Q
P
Y
R
Q
V
V
G
F
F
--
E
S
D
E
-
S
K
Y
SNDI
D
-----------
F
P
G
F
M
-
V
----
E
V
-----
P
N
G
I
Y
Y
---
G
F
P
S
F
-
G
G
C
G
-
L
K
L
G
Y
H
T
F
G
Q
K
I
--
D
-
P
D
TINR
E
--
F
G
V
Y
P
E
D
-
E
S
N
L
R
A
F
L
E
E
Y
M
P
G
--
A
N
---
G
E
L
K
R
G
A
V
--
C
M
Y
T
K
------------
T
L
D
E
H
F
---------
I
I
D
L
H
----
P
-
E
H
S
N
-
V
V
I
A
A
G
FS-
G
H--
G
F
K
F
S
S
G
V
G
E
V
L
S
Q
L
A
-----
L
T
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
49.48
14%
-78
- C1 -
1Y56
4
?
B:
[2-356]
----------
L
P
E
K
S
E
I
V
V
I
G
G
G
I
V
G
V
T
I
A
H
E
L
A
K
-
R
G
E
E
V
T
V
I
E
K
R
-
F
-
I
G
S
--
G
S
T
F
R
C
G
T
G
I
R
Q
Q
F
--
N
D
-
E
A
N
V
R
V
M
K
R
S
V
E
L
W
K
K
Y
S
E
E
Y
G
-----
F
S
-
F
K
Q
T
G
Y
L
F
L
----
L
Y
D
D
E
-
E
---
V
K
T
F
-
K
-----
R
N
I
E
I
Q
N
-
K
F
G
V
--
P
T
K
L
I
T
P
E
E
A
K
E
I
V
P
L
--
L
D-------------
I
S
E
-
V
--------
I
A
A
S
W
N
----
P
T
D
G
K
A
D
P
F
E
A
T
--
T
A
F
A
V
K
A
K
E
Y
G
A
K
L
L
E
Y
T
E
V
K
G
F
L
I
E
-
N
N
E---------------
I
K
G
V
K
T
N
-------
K
--
G
I
I
K
T
G
I
V
V
N
A
T
N
A
W
A
N
L
I
N
A
M
A
G
-
I
K
-
T
-
K
I
P
I
E
P
Y
K
H
Q
A
V
I
T
--
Q
P
I
K
-
R
-
G
T---
I
-----------
N
P
-
M
V
-
I
----
S
---
F
--
K
Y
G
H
A
Y
---
L
T
Q
T
F
-
H
G
-
G
-
I
I
G
G
I
G
Y
E
I
G
P
-----
T
Y
----
D
--
L
T
P
T
Y
E
F
-
L
R
E
V
S
Y
Y
F
T
K
I
I
P
--
A
L
K
--
N
L
L
I
L
R
T
W
A
--
G
Y
Y
A
K
------------
T
P
D
S
N
P
---------
A
I
G
R
I
----
E
-
E
L
N
D
-
Y
Y
I
A
A
G
FS-
G
H--
G
F
M
M
A
P
A
V
G
E
M
V
A
E
L
I
-----
T
K
G
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
HHSearch
48.22
15%
-72
- C1 -
3AXB
7
?
A:
[21-419]
-----------
M
P
R
F
D
Y
V
V
V
G
A
G
V
V
G
L
A
A
A
Y
Y
L
K
V
W
S
G
G
S
V
L
V
V
D
A
G
-
H
A
P
G
S
--
G
D
S
G
R
S
M
A
A
F
R
T
F
F
S
S
T
M
---
N
R
L
V
A
G
S
T
V
R
L
F
E
D
A
Q
R
G
G
E
-----
D
L
G
L
V
K
S
G
Y
L
F
V
----
Y
D
R
-
E
-
R
---
W
R
E
V
------
E
E
P
L
R
E
A
G
-
E
E
G
--
R
D
Y
L
I
I
P
P
E
E
L
E
R
R
L
G
M
--
N
TRVSDGE
E
A
E
V
L
GV
G
-
D
-
V
--------
E
G
A
V
-
L
I
---
R
S
A
G
F
L
D
A
E
K
V
V
--
D
Y
Y
Y
R
R
A
S
G
A
G
V
E
F
I
F
G
R
R
V
V
G
V
E
L
K
-
P
R
VELGIEGEPLPWQE
A
R
A
S
A
A
V
L
S
---
D
---
G
-
T
R
V
E
V
G
E
K
L
V
V
A
A
G
V
W
S
N
R
L
L
N
P
L
G
----
I
-
D
T
F
S
R
P
K
K
R
M
V
F
R
V
--
S
A
S
T
-
E
-
G
L
R
--
R
I
M
R
EGDLAGAG
A
P
-
P
L
-
I
----
I
------
L
P
K
R
V
L
---
V
R
P
A
P
R
E
G
-
S
-
F
W
V
Q
L
S
D
N
L
G
R
P
FA
L
-
E
E
----
D
--
P
Q
P
E
E
H
Y
Y
S
L
A
I
L
P
I
L
S
L
Y
L
P
--
Q
F
Q
--
D
A
Y
P
S
G
G
W
A
--
G
H
Y
D
I
------------
S
F
D
A
N
P
---------
V
V
F
E
P
------
W
E
S
G
-
I
V
V
A
A
G
TS-
G
S--
G
I
M
K
S
D
S
I
G
R
V
A
A
A
V
A
-----
L
G
M
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------