@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3861: (2016-02-21 )
MVEPQEGKTRFHDFNLAPSLMHAIHDLGFPYCTPIQAQVLGFTLRGQDAIGRAQTGTGKTAAFLISIITQLLQTPPPKERYMGEPRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARFCDILVATPGRLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPHKGERQTLLFSATFTDDVMNLAKQWTVDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVAQNNWERVMVFANRKDEVRRIEERLTKDGISAAQMSGDVPQHKRIRTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGTSISFAGEDDAFALPPIEELLGRKITCEMPPAELLKPVPRKH
Atome Classification :
(55 SA)
.........10..-......20........30........40....--.--...50........60........70......--.-----------.-80...----------.....90........100.......-110.-.---......120.......130.......140......-.--150.-.-.....--160.......170-.--.-.....180.-...--..--.-----190.......200.......210.......220...----....230-....-.....240-..-.----.....250..-.....260........270.......280-.........290.......300.......310.......320.......330....------.----..340.........350.......360..-.-...-.370.......380.......390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVEPQEG
K
T
RFHD-FNL
A
P
S
L
M
H
A
I
H
DLGFPYCTPIQ
A
Q
V
L
G
F
T
LR--G--QDAIGRAQTGT
G
K
T
A
A
F
L
I
S
I
I
T
Q
L
LQTPP
P
--
K
-----------
E
-RYMGE----------P
R
A
L
I
IAP
T
R
E
L
V
V
Q
I
A
K
D
A
A
A
L
T
K-YT-G-
L
---
N
V
M
T
F
VGGM
D
F
D
K
Q
L
K
Q
L
E
A
R
F
C
D
I
L
VATPG
R
L
LD-F--NQRG-
E
-
V
H
L
D
M
--
V
E
V
M
VLDE
A
D
R
M
L-D--M-G
F
I
P
Q
V
R
Q
I
-
I
R
Q--TP--H-----KGE
R
Q
T
L
L
F
S
AT
F
T
D
D
V
M
N
L
A
K
QWTVD
P
A
I
V
E
IEPE----NV
A
S
D
---
T
V
E
Q
-
H
V
Y
A
VA-G-S
D
-
K
----
Y
K
L
L
Y
N
L
V
AQ-NNW
E
R
V
-
M
V
F
ANR
K
D
E
V
R
R
I
E
E
R
L
T
KD---GI
S
A
A
Q
MSGDVP
Q
H
K
R
I
R
T
L
E
GFREG
K
I
R
V
L
V
ATDVAGR
G
I
H
IDG
I
S
H
V
I
N
FTLPE------D----P
D
D
--
Y
V
H
R
IGRTGRAGASGT
S
I
S
FAGED-D-AFA-LP
P
I
E
E
L
LG
R
K
I
TCEM
P
P
A
E
L
LKPVPRKH
3
PsiBlast_PDB
87.49
38%
-106
- C6 -
4D25
4
?
A:
[52-413]
----------
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
S
-----------
E
-
N
G
C
A
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
-
V
-
L
---
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
--
V
E
R
N
-
R
-
V
S
F
G
S
--
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
F
M
P
S
I
E
K
M
-
M
L
H
--
P
T
MV
E
-----
T
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
G
A
S
T
---
D
V
E
Q
-
I
F
I
E
V
T
-
K
-
Y
E
-
K
----
R
N
S
L
K
Q
L
I
E
E
-
N
D
G
K
R
I
-
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
----
I
D
E
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-
Q
-
D
L
A
-
L
----------------------------
4
PsiBlast_PDB
87.28
38%
-105
- C6 -
4D26
4
?
A:
[52-413]
----------
F
E
T
-
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
--
G
--
R
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
S
-----------
E
-
N
G
C
A
Q
----------
P
Q
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
-
G
S
-
V
-
L
---
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
H
I
L
V
A
T
P
G
R
L
H
D
-
F
--
V
E
R
N
-
R
-
V
S
F
G
S
--
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
F
M
P
S
I
E
K
M
-
M
L
H
--
P
T
MV
E
-----
T
T
K
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
----
G
G
A
S
T
---
D
V
E
Q
-
I
F
I
E
V
T
-
K
-
Y
E
-
K
----
R
N
S
L
K
Q
L
I
E
E
-
N
D
G
K
R
I
-
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
---
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
----
I
D
E
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
S
D
-
Q
-
D
L
A
-
L
----------------------------
104
HHSearch
86.04
38%
-118
- C6 -
2I4I
1
DDX3X_HUMAN
A:
[13-410]
------
H
I
E
S
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
A
L
R
A
M
K
E
NGRY
G
-
R
R
K
Q
Y
----------
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
--
D
T
MP
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
--------
T
S
E
---
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
D
-
K
----
R
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
T
-
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
----
I
E
E
--
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
R
-
N
-
I
N
I
-
T
K
D
L
L
D
L
L
V
E
--
A
K
Q
E
V
P
S
W
L
E
N
M
A
----
2
PsiBlast_PDB
84.79
38%
-114
- C6 -
4PXA
5
DDX3X_HUMAN
A:
[67-432]
----------
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
-----------
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
P
--
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
----
G
S
T
S
E
---
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
D
-
K
----
R
S
F
L
L
D
L
L
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
----
I
E
E
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
E
-------------------------------------
1
PsiBlast_PDB
84.63
39%
-126
- C6 -
2I4I
1
DDX3X_HUMAN
A:
[17-382]
----------
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
-----------
A
L
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
P
--
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
--------
T
S
E
---
N
I
T
Q
-
K
V
V
W
V
E
-
E
-
S
D
-
K
----
R
S
F
L
L
D
L
L
N
A
-
T
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
---
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
----
I
E
E
--
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
E
-------------------------------------
6
PsiBlast_PDB
83.93
39%
-107
- C6 -
4KBF
3
?
A:
[3-361]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
---------
N
V
I
K
D
EPV
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
G
-
R
----
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
----
A
E
A
--
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
R
R
F
-----------------
24
PsiBlast_CBE
83.69
39%
-105
- C6 -
4KBG
4
?
B:
[3-361]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
---------
N
V
I
K
D
EPV
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
G
-
R
----
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
----
A
E
A
--
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
R
R
F
-----------------
103
HHSearch
83.05
36%
-104
- C6 -
2DB3
3
VASA1_DROME
A:
[54-420]
------
P
I
Q
H
F
T
S
-
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
H
E
----------------
L
E
L
G
R
----------
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
-
F
--
V
D
R
T
-
F
-
I
T
F
E
D
--
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
S
E
D
M
R
R
I
-
M
T
H
--
V
T
--
M
-----
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
A
C
S
---
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
A
-
K
----
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
----
I
D
D
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
D
P
E
K
D
-
R
A
I
-
A
A
D
L
V
K
I
L
---------------------
37
PsiBlast_CBE
82.96
33%
-121
- C6 -
3EWS
1
DD19B_HUMAN
A:
[64-433]
----------
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
----
E
P
--
A
-----------
N
-
K
Y
-------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
---
K
L
A
Y
A
V
R
G
N
K
L
E
R
G
Q
K
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
-
K
F
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
P
--
R
-----
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
E
T
L
D
---
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
K
----
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
KDGN
P
D
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
-----------------
25
PsiBlast_CBE
82.79
39%
-112
- C6 -
4KBF
1
?
B:
[3-361]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
---------
N
V
I
K
D
EPV
T
Y
E
E
-
E
A
V
P
A
P
-
V
-
R
G
-
R
----
L
E
V
L
S
D
L
L
Y
V
-
A
S
P
D
R
A
-
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
---
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
----
A
E
A
--
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
G
P
R
-
E
-
R
R
D
-
V
E
A
L
E
R
A
V
G
R
R
F
-----------------
13
PsiBlast_PDB
82.68
32%
-117
- C6 -
2J0S
3
IF4A3_HUMAN
A:
[39-403]
----------
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
--------------------
D
-
I
Q
V
R
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
-
N
-
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
--
I
R
R
R
-
S
-
L
R
T
R
A
--
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
P
--
P
-----
A
T
--
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
F
V
A
V
E
-
R
-
E
E
W
K
----
F
D
T
L
C
D
L
Y
D
T
-
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
----
R
E
L
--
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
-
E
M
P
------------
36
PsiBlast_CBE
82.63
33%
-120
- C6 -
3FHT
4
DD19B_HUMAN
A:
[27-396]
----------
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
----
E
P
--
A
-----------
N
-
K
Y
-------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
---
K
L
A
Y
A
V
R
G
N
K
L
E
R
G
Q
K
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
-
K
F
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
P
--
R
-----
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
E
T
L
D
---
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
K
----
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
KDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
-----------------
26
PsiBlast_CBE
82.57
32%
-113
- C6 -
3EX7
4
IF4A3_HUMAN
H:
[40-404]
----------
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
----
L
Q
C
L
D
I
--
Q
-----------
V
-
R
---
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
-
N
-
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
--
I
R
R
R
-
S
-
L
R
T
R
A
--
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
P
--
P
-----
A
T
--
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
F
V
A
V
E
-
R
-
E
E
W
K
----
F
D
T
L
C
D
L
Y
D
T
-
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
----
R
E
L
--
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
-
E
M
P
------------
22
PsiBlast_CBE
82.36
36%
-107
- C6 -
2DB3
3
VASA1_DROME
C:
[58-403]
----------
F
T
S
-
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
----
H
-----------
E
-
L
E
L
G
R
----------
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
-
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
-
F
--
V
D
R
T
-
F
-
I
T
F
E
D
--
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
S
E
D
M
R
R
I
-
M
T
H
--
V
T
--
M
-----
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
A
C
S
---
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
A
-
K
----
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
----
I
D
D
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
----------------------------------------
35
PsiBlast_CBE
82.23
33%
-119
- C6 -
3FHT
6
DD19B_HUMAN
B:
[27-396]
----------
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
----
E
P
--
A
-----------
N
-
K
Y
-------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
---
K
L
A
Y
A
V
R
G
N
------
K
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
-
K
F
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
P
--
R
-----
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
E
T
L
D
---
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
K
----
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
KDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
-----------------
21
PsiBlast_CBE
82.10
36%
-107
- C6 -
2DB3
3
VASA1_DROME
D:
[58-403]
----------
F
T
S
-
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
--
G
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
L
E
D
P
----
H
-----------
E
-
L
E
L
G
R
----------
P
Q
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
-
E
S
-
Y
-
L
---
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
-
N
E
C
I
T
R
G
C
H
V
V
I
A
T
P
G
R
L
L
D
-
F
--
V
D
R
T
-
F
-
I
T
F
E
D
--
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
S
E
D
M
R
R
I
-
M
T
H
--
V
T
--
M
-----
R
P
E
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
----
G
G
A
C
S
---
D
V
K
Q
-
T
I
Y
E
V
N
-
K
-
Y
A
-
K
----
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
T
-
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
---
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
----
I
D
D
--
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
----------------------------------------
96
HHSearch
82.08
34%
-117
- C6 -
3EIQ
-
IF4A1_HUMAN
A:
[29-400]
-----
E
I
V
D
S
F
D
D
-
M
N
L
S
E
S
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
L
P
C
I
K
--
G
--
Y
D
V
I
A
Q
A
Q
S
G
T
G
K
T
A
T
F
A
I
S
I
L
Q
Q
I
E
L
D
L
---------------------
K
A
----------
T
Q
A
L
V
L
A
P
T
R
E
L
A
Q
Q
I
Q
K
V
V
M
A
L
G
D
-
Y
M
-
G
-
A
---
S
C
H
A
C
I
G
G
T
N
V
R
A
E
V
Q
K
L
Q
M
E
A
P
H
I
I
V
G
T
P
G
R
V
F
D
-
M
--
L
N
R
R
-
Y
-
L
S
P
K
Y
--
I
K
M
F
V
L
D
E
A
D
E
M
L
-
S
--
R
-
G
F
K
D
Q
I
Y
D
I
-
F
Q
K
--
L
N
---------
S
N
T
Q
V
V
L
L
S
A
T
M
P
S
D
V
L
E
V
T
K
K
F
M
R
D
P
I
R
I
L
V
K
K
E
----
E
L
T
L
E
---
G
I
R
Q
-
F
Y
I
N
V
E
R
E
-
E
W
-
K
----
L
D
T
L
C
D
L
Y
E
T
-
L
T
I
T
Q
A
-
V
I
F
I
N
T
R
R
K
V
D
W
L
T
E
K
M
H
A
R
---
D
F
T
V
S
A
M
---
M
D
Q
K
E
R
D
V
I
M
R
E
F
R
S
G
---
V
L
I
T
T
D
L
L
A
--
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
T
------
N
----
R
E
N
--
Y
I
H
R
I
G
R
G
-------
V
A
I
N
M
V
T
E
E
-
D
-
K
R
T
-
L
R
D
I
E
T
F
Y
N
T
S
I
E
E
M
P
L
------------
17
PsiBlast_PDB
81.98
31%
-119
- C6 -
4CT4
3
DDX6_HUMAN
B:
[7-370]
----------
F
E
D
-
Y
C
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
E
E
S
I
P
I
A
L
S
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
R
L
--------------------
D
-
L
K
K
D
N
----------
I
Q
A
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
K
-
H
M
-
G
G
A
---
K
V
M
A
T
T
G
G
T
N
L
R
D
D
I
M
R
L
D
D
T
V
-
H
V
V
I
A
T
P
G
R
I
L
D
-
L
--
I
K
K
G
-
V
-
A
K
V
D
H
--
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
L
T
--
L
P
--
K
-------
N
R
Q
I
L
L
Y
S
A
T
F
P
L
S
V
Q
K
F
M
N
S
H
L
Q
K
P
Y
E
I
N
L
M
E
E
----
L
T
L
K
G
---
V
T
Q
Y
-
Y
A
Y
-
V
T
-
E
-
R
Q
-
K
----
V
H
C
L
N
T
L
F
S
R
-
L
Q
I
N
Q
S
-
I
I
F
C
N
S
S
Q
R
V
E
L
L
A
K
K
I
S
Q
L
---
G
Y
S
C
F
Y
I
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
----
A
E
T
--
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
Y
D
-
D
-
R
F
N
-
L
K
S
I
E
E
Q
L
G
T
E
I
----------
K
P
I
P
---
9
PsiBlast_PDB
81.92
32%
-111
- C6 -
2HYI
3
IF4A3_HUMAN
C:
[40-404]
----------
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
----
L
Q
C
L
D
I
--
Q
-----------
V
-
R
---
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
-
N
-
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
--
I
R
R
R
-
S
-
L
R
T
R
A
--
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
P
--
P
-----
A
T
--
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
F
V
A
V
E
-
R
-
E
E
W
K
----
F
D
T
L
C
D
L
Y
D
T
-
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
----
R
E
L
--
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
-
E
M
P
------------
10
PsiBlast_PDB
81.85
32%
-112
- C6 -
3EX7
4
IF4A3_HUMAN
C:
[40-404]
----------
F
D
T
-
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
--
G
--
R
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
----
L
Q
C
L
D
I
--
Q
-----------
V
-
R
---
E
----------
T
Q
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
-
Y
M
-
N
-
V
---
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
D
Y
G
-
Q
H
V
V
A
G
T
P
G
R
V
F
D
-
M
--
I
R
R
R
-
S
-
L
R
T
R
A
--
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
P
--
P
-----
A
T
--
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
I
R
I
L
V
K
R
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
F
V
A
V
E
-
R
-
E
E
W
K
----
F
D
T
L
C
D
L
Y
D
T
-
L
T
I
T
Q
A
-
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
---
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
----
R
E
L
--
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
N
D
-
D
-
I
R
I
-
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
-
E
M
P
------------
38
PsiBlast_CBE
81.67
31%
-134
- C6 -
2VSX
1
IF4A_YEAST
B:
[23-387]
---------
K
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--------------------
D
-
T
S
V
K
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
---
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
--
I
Q
R
R
-
R
-
F
R
T
D
K
--
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
P
--
P
-----
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
E
Y
K
----
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
----
K
E
N
--
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
T
Q
I
E
-
E
L
P
------------
39
PsiBlast_CBE
81.21
31%
-133
- C6 -
2VSX
1
IF4A_YEAST
A:
[23-387]
---------
K
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--------------------
D
-
T
S
V
K
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
---
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
--
I
Q
R
R
-
R
-
F
R
T
D
K
--
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
P
--
P
-----
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
E
Y
K
----
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
----
K
E
N
--
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
T
Q
I
E
-
E
L
P
------------
32
PsiBlast_CBE
81.11
33%
-115
- C6 -
3G0H
4
DD19B_HUMAN
A:
[43-412]
----------
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
----
E
P
--
A
-----------
N
-
K
Y
-------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
---
K
L
A
Y
A
V
R
G
N
K
L
E
R
G
Q
K
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
-
K
F
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
P
--
R
-----
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
E
T
L
D
---
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
-
R
D
E
K
----
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
KDGN
P
D
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
-
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
-----------------
100
HHSearch
80.66
33%
-109
- C6 -
3FHT
4
DD19B_HUMAN
A:
[22-399]
-----
Y
S
V
K
S
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
E
P
A
---------------------
N
K
Y
----------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
-
F
Y
-
P
E
L
---
K
L
A
Y
A
V
R
G
N
K
----
L
E
R
G
Q
K
I
S
E
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
K
F
-
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
--
T
Q
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
---------
P
R
N
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
----
E
E
T
L
D
---
T
I
K
Q
-
Y
Y
V
L
C
S
-
S
R
D
E
-
K
----
F
Q
A
L
C
N
L
Y
G
A
-
I
T
I
A
Q
A
-
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
---
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
----
N
E
T
--
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
S
K
H
S
-
M
N
I
-
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
--------------
41
PsiBlast_CBE
80.39
31%
-131
- C6 -
2VSO
1
IF4A_YEAST
A:
[23-387]
---------
K
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--------------------
D
-
T
S
V
K
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
---
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
--
I
Q
R
R
-
R
-
F
R
T
D
K
--
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
P
--
P
-----
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
E
Y
K
----
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
----
K
E
N
--
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
T
Q
I
E
-
E
L
P
------------
40
PsiBlast_CBE
80.12
31%
-132
- C6 -
2VSO
1
IF4A_YEAST
B:
[23-387]
---------
K
F
D
D
-
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
--
G
--
H
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
--------------------
D
-
T
S
V
K
A
----------
P
Q
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
F
-
H
M
-
D
-
I
---
K
V
H
A
C
I
G
----------
L
--
R
D
A
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
--
I
Q
R
R
-
R
-
F
R
T
D
K
--
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
P
--
P
-----
T
T
--
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
----
E
L
T
L
E
---
G
I
K
Q
-
F
Y
V
N
V
E
-
E
-
E
E
Y
K
----
Y
E
C
L
T
D
L
Y
D
S
-
I
S
V
T
Q
A
-
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
---
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
----
K
E
N
--
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
N
E
-
D
-
V
G
A
-
M
R
E
L
E
K
F
Y
S
T
Q
I
E
-
E
L
P
------------
42
PsiBlast_CBE
79.82
32%
-117
- C6 -
3RRN
2
DBP5_YEAST
A:
[7-370]
----------
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
----
N
P
--
E
-----------
D
----
A
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
-
I
---
T
S
Q
L
I
V
P
D
-
S
F
E
K
N
-
K
Q
I
N
A
Q
---
V
I
V
G
T
P
G
T
V
L
D
-
L
--
M
R
R
K
-
L
-
M
Q
L
Q
K
--
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
P
--
K
-------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
----------
D
---
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
-
K
----
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
----
P
A
T
--
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
--------------------
19
PsiBlast_PDB
79.07
33%
-112
- C6 -
4BRW
2
DHH1_YEAST
A:
[3-361]
----------
F
E
D
-
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
--
G
--
R
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
----
L
E
K
V
K
P
--
K
---------------
L
N
K
----------
I
Q
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
-
H
C
-
G
-
I
---
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
N
E
T
-
V
H
I
L
V
G
T
P
G
R
V
L
D
-
L
--
A
S
R
K
-
V
-
A
D
L
S
D
--
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
--
R
-
D
F
K
T
I
I
E
Q
I
-
L
S
F
--
L
P
---------
P
T
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
D
E
F
M
D
K
H
L
H
K
P
Y
E
I
N
L
-
M
E
----
E
L
T
L
K
---
G
I
T
Q
-
Y
Y
A
F
V
E
-
E
-
R
Q
-
K
----
L
H
C
L
N
T
L
F
S
K
-
L
Q
I
N
Q
A
-
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
---
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
----
A
E
T
--
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
W
N
-
D
-
R
F
N
-
L
Y
K
I
E
Q
E
L
G
T
E
I
-----------------
44
PsiBlast_CBE
78.42
32%
-114
- C6 -
3PEW
9
DBP5_YEAST
A:
[7-370]
----------
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
----
N
P
--
E
-----------
D
----
A
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
-
I
---
T
S
Q
L
I
V
P
D
-
S
F
E
K
N
-
K
Q
I
N
A
Q
---
V
I
V
G
T
P
G
T
V
L
D
-
L
--
M
R
R
K
-
L
-
M
Q
L
Q
K
--
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
P
--
K
-------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
N
V
D
---
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
-
K
----
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
----
P
A
T
--
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
--------------------
45
PsiBlast_CBE
78.04
32%
-114
- C6 -
3PEY
11
DBP5_YEAST
A:
[7-370]
----------
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
----
N
P
--
E
-----------
D
----
A
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
-
I
---
T
S
Q
L
I
V
P
D
-
S
F
E
K
N
-
K
Q
I
N
A
Q
---
V
I
V
G
T
P
G
T
V
L
D
-
L
--
M
R
R
K
-
L
-
M
Q
L
Q
K
--
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
P
--
K
-------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
N
V
D
---
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
-
K
----
F
D
V
L
T
E
L
Y
G
L
-
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
----
P
A
T
--
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
--------------------
105
HHSearch
77.57
32%
-109
- C6 -
3PEY
11
DBP5_YEAST
A:
[4-369]
-------
A
K
S
F
D
E
-
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
N
P
E
---------------------
D
A
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
-
I
---
T
S
Q
L
I
V
P
D
S
F
-----
E
K
N
K
Q
I
N
A
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
--
M
R
R
K
-
L
-
M
Q
L
Q
K
--
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
---------
P
K
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
----
E
V
N
V
D
---
A
I
K
Q
-
L
Y
M
D
C
K
N
E
-
A
D
-
K
----
F
D
V
L
T
E
L
Y
G
L
-
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
----
P
A
T
--
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
S
F
N
I
-
L
S
A
I
Q
K
Y
F
---------------------
43
PsiBlast_CBE
76.45
32%
-117
- C6 -
3RRM
1
DBP5_YEAST
A:
[11-370]
---------------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
--
N
P
P
R
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
----
N
P
--
E
-----------
D
----
A
S
----------
P
Q
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
-
F
T
-
K
-
I
---
T
S
Q
L
I
V
P
D
-
S
F
E
K
N
-
K
Q
I
N
A
Q
---
V
I
V
G
T
P
G
T
V
L
D
-
L
--
M
R
R
K
-
L
-
M
Q
L
Q
K
--
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
P
--
K
-------
D
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
--------
V
N
V
D
---
A
I
K
Q
L
Y
M
D
C
K
N
-
E
-
A
D
-
K
----
F
D
V
L
T
E
L
Y
G
V
-
M
T
I
G
S
S
-
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
---
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
----
P
A
T
--
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
-
N
-
S
F
N
I
L
S
A
I
Q
K
Y
F
G
--------------------
101
HHSearch
71.87
30%
-106
- C6 -
3I5X
3
MS116_YEAST
A:
[78-457]
---------------
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
Q
K
T
I
K
P
I
L
S
SE
D
--
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
H
L
I
N
T
K
F
D
-----------------
S
Q
Y
M
----------
V
K
A
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
D
-
M
N
Y
G
-
L
KKY
A
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
K
L
R
P
N
I
V
I
A
T
P
G
R
L
I
D
-
V
--
L
E
K
Y
S
N
-
K
F
F
R
F
--
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
N
--
E
K
NSKS
A
D
N
I
K
T
L
L
F
S
A
T
L
D
D
K
V
Q
K
L
A
N
N
I
M
N
K
K
E
C
L
F
L
D
T
V
DKNE
P
E
A
H
E
---
R
I
D
Q
-
S
V
V
I
S
E
-
K
F
A
N
-
S
I
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
D
S
N
Y
K
A
-
I
I
F
A
P
T
V
K
F
T
S
F
L
C
S
I
L
K
N
E
FKK
D
L
P
I
L
E
F
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
----
L
A
N
--
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
K
D
-
E
-
L
P
F
-
V
R
E
L
-------------------------
62
PsiBlast_CBE
67.52
40%
-144
- C6 -
4PX9
1
DDX3X_HUMAN
C:
[67-281]
----------
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
-----------
A
L
R
A
M
K
E
NGRYGRRKQY
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
P
--
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
67.31
40%
-144
- C6 -
4PX9
1
DDX3X_HUMAN
A:
[67-281]
----------
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
-----------
A
L
R
A
M
K
E
NGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
P
--
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
67.05
40%
-144
- C6 -
4PX9
1
DDX3X_HUMAN
B:
[67-281]
----------
F
S
D
-
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
--
K
--
R
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
Y
S
D
G
P
G
--
E
-----------
A
L
R
A
M
K
E
NGRYG
R
R
K
Q
Y
P
I
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
-
R
S
-
R
-
V
---
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
E
-
R
G
C
H
L
L
V
A
T
P
G
R
L
V
D
-
M
--
M
E
R
G
-
K
-
I
G
L
D
F
--
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
P
--
P
-----
K
G
V
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
66.01
43%
-128
- C6 -
3NBF
2
?
A:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
65.97
43%
-130
- C6 -
2GXQ
2
?
A:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
65.64
43%
-128
- C6 -
2GXS
3
?
A:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
65.47
43%
-127
- C6 -
2GXS
4
?
B:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
65.34
41%
-134
- C6 -
3FE2
3
DDX5_HUMAN
A:
[31-231]
----------
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
-
N
H
Q
P
F
--
L
-----------
E
-
R
G
D
G
-----------
P
I
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
C
-
R
-
L
---
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
E
-
R
G
V
E
I
C
I
A
T
P
G
R
L
I
D
-
F
--
L
E
C
G
-
K
-
T
N
L
R
R
--
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
K
I
-
V
D
Q
--
I
---------
R
P
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
65.30
41%
-137
- C6 -
3FE2
4
DDX5_HUMAN
B:
[31-231]
----------
F
Y
E
-
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
--
G
--
L
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
-
N
H
Q
P
F
--
L
-----------
E
-
R
G
D
G
-----------
P
I
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
R
-
A
C
-
R
-
L
---
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
E
-
R
G
V
E
I
C
I
A
T
P
G
R
L
I
D
-
F
--
L
E
C
G
-
K
-
T
N
L
R
R
--
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
K
I
-
V
D
Q
--
I
---------
R
P
D
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
65.15
43%
-132
- C6 -
3NBF
4
?
C:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
64.97
43%
-133
- C6 -
3MWL
2
?
B:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
64.95
39%
-133
- C6 -
3BER
4
DDX47_HUMAN
A:
[36-242]
I
V
E
E
E
E
T
K
T
-
F
K
D
-
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
--
G
--
R
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
A
L
L
E
T
P
----------------
Q
-
R
L
F
--------------
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
-
S
I
-
G
-
V
---
Q
S
A
V
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
P
H
I
I
I
A
T
P
G
R
L
I
D
-
H
L
E
N
T
K
G
---
F
N
L
R
A
--
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
--
M
-
D
F
E
T
E
V
D
K
I
-
L
K
V
--
I
P
--
R
-------
D
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
64.77
38%
-151
- C6 -
3IUY
2
DDX53_HUMAN
A:
[19-228]
--------
C
R
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
D
-----------------------
N
G
-----------
P
G
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
S
--
Y
K
-
G
-
L
---
K
S
I
C
I
Y
G
------
Q
I
E
D
I
-
S
K
G
V
D
I
I
I
A
T
P
G
R
L
N
D
-
L
--
Q
M
N
N
-
S
-
V
N
L
R
S
--
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
F
E
P
Q
I
R
K
I
-
L
L
D
--
V
---------
R
P
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
64.55
43%
-130
- C6 -
3MWK
2
?
B:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
64.55
43%
-131
- C6 -
3NBF
2
?
D:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
64.43
36%
-140
- C6 -
2PL3
6
DDX10_HUMAN
A:
[25-232]
--------
T
R
F
S
D
-
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
--
G
--
K
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
L
Q
W
T
--
S
-----------
T
-
D
G
L
G
-------------
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
-
N
H
-
D
-
F
---
S
A
G
L
I
I
G
G
--
L
K
H
E
A
E
R
I
N
N
--
I
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
--
D
E
T
V
-
S
-
F
H
A
T
D
--
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
--
M
-
G
F
A
D
T
M
N
A
V
-
I
E
N
--
L
P
--
K
-----
K
--
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
W
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
64.26
43%
-125
- C6 -
3NBF
2
?
B:
[3-205]
----------
F
K
D
-
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
--
G
--
K
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
---
A
P
S
--
Q
-----------
E
-
R
G
R
-
K
----------
P
R
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
-
H
----
L
---
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
-
K
E
A
L
L
R
G
A
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
--
L
R
Q
G
-
V
-
L
D
L
S
R
--
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
P
--
P
-----
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
62.68
38%
-144
- C6 -
3IUY
2
DDX53_HUMAN
B:
[19-228]
--------
C
R
F
K
D
A
F
Q
Q
Y
P
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
--
G
--
I
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
D
S
----------------------
N
G
-----------
P
G
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
A
E
C
S
K
Y
S
--
Y
K
-
G
-
L
---
K
S
I
C
I
Y
G
---------------
V
D
I
I
I
A
T
P
G
R
L
N
D
-
L
--
Q
M
N
N
-
S
-
V
N
L
R
S
--
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
--
M
-
E
F
E
P
Q
I
R
K
I
-
L
L
D
--
V
---------
R
P
D
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
M
I
V
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
62.53
33%
-131
- C6 -
1T6N
1
DX39B_HUMAN
B:
[16-215]
----------
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--------------------
E
-
P
V
T
G
Q
----------
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M
P
N
-
V
---
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
--
A
R
N
K
-
S
-
L
N
L
K
H
--
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
M
R
R
D
V
Q
E
I
-
F
R
M
--
T
P
--
H
-------
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
61.96
33%
-131
- C6 -
1T6N
1
DX39B_HUMAN
A:
[16-215]
----------
F
R
D
-
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
--
G
--
M
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--------------------
E
-
P
V
T
G
Q
----------
V
S
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
-
Y
M
P
N
-
V
---
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
--
A
R
N
K
-
S
-
L
N
L
K
H
--
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q-
L
-
D
M
R
R
D
V
Q
E
I
-
F
R
M
--
T
P
--
H
-------
E
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
61.01
32%
-137
- C6 -
3FMO
1
DD19B_HUMAN
B:
[94-300]
----------
F
E
E
-
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
----
E
P
--
A
-----------
N
-
K
Y
-------------
P
Q
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
Y
P
-
E
-
L
---
K
L
A
Y
A
V
R
G
N
K
L
E
R
G
Q
K
I
S
E
----
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
--
C
S
K
L
-
K
F
I
D
P
K
K
--
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
P
--
R
-----
N
C
--
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
52.76
34%
-108
- C6 -
3DKP
4
DDX52_HUMAN
A:
[32-228]
-----------
Q
E
-
Y
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
M
Q
A
I
P
V
M
L
H
--
G
--
R
E
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
Q
L
K
Q
--
P
A
--
N
-----------
K
-
G
F
--------------
R
A
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
I
S
E
-
G
T
-
G
-
F
---
R
I
H
M
I
H
K
A
A
V
A
A
K
K
F
G
P
K
S
S
K
K
F
D
I
L
V
T
T
P
N
R
L
I
Y
-
L
--
L
K
Q
D
-
P
-
P
G
I
D
L
AS
V
E
W
L
V
V
D
E
S
D
K
L
F
-
E
D
G--
G
F
R
D
Q
L
A
S
I
F
L
A
C
--
T
S
--
H
-----
K
V
R
R
A
--
M
F
S
A
T
F
A
Y
D
V
----
E
Q
W
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------