@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5313: (2016-03-06 )
MTMNDEPQSSSLDNFWMPFTANRQFKARPRLLESAEGIHYIAQGGRRILDGTAGLWCCNAGHGRREISEAVARQIATLDYAPPFQMGHPLPFELAARLTEIAPPSLNKVFFTNSGSESADTALKIALAYQRAIGQGTRTRLIGRELGYHGVGFGGLSVGGMVNNRKAFSANLLPGVDHLPHTLDVARNAFTVGLPEHGVEKAEELERLVTLHGAENIAAVIVEPMSGSAGVVLPPKGYLQRLREITRKHGILLIFDEVITGFGRVGEAFAAQRWGVVPDLLTCAKGLTNGSIPMGAVFVDEKIHAAFMQGPQGAIEFFHGYTYSGHPVACAAALATLDIYRRDDLFQRAVELEGYWQDALFSLRDLPNVVDIRAVGLVGGVQLAPHADGPGKRGYDVFERCFWEHDLMVRVTGDIIAMSPPLIIDKPHIDQIVERLAQAIRASV
Atome Classification :
(32 SA)
.........10..--......20....--....30........40........50........60........70........-80........90........100...-....110.......120.......130.......140.......150.......160..---------.....170-.......180.......190....-..-..200..-----.....210.......220...-....230.......240.......250.......260.......270.-......280.......290.......300.......--310...-.-.....320.......330.......340.......350----........360........370.......380--------.--.......390--....---.....400.......410-.-......420.......430-------.......440..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTMNDEPQSSSLD--NFWMPFTANRQF--KARP
R
L
L
E
SAEGI
H
Y
I
A
QGG
R
R
ILDGTA
G
L
W
C
CNAGH
G
R
R
E
I
S
E
A
V
A
R
Q
I
A
TLD-YAPPFQMGHPL
P
F
E
L
A
A
R
L
T
EIAPPS-L
N
K
V
F
F
TNSGSESA
D
T
A
L
K
I
A
L
A
Y
Q
R
A
IGQG
T
R
T
R
L
I
G
R
ELGYHGVGFGG
L
S
VG
G
M
VNN---------RKAFSANL-LPGVDHLP
H
T
L
D
V
ARN
A
F
T
-VGLP-EH-G
V
E
K
A
E
E
-----
L
E
R
L
V
T
LHGAE
N
I
A
A
V
I
V
EPM-SGSA
G
V
V
LP
P
K
G
Y
L
Q
R
L
R
E
I
T
R
KH
G
I
L
L
I
F
D
E
V
I
T
G
F
G
R
V
G
E
A
F
A
A
Q
R-WGV
V
P
D
L
L
T
C
A
K
GLTNGSI
P
M
G
A
V
F
VDE
K
I
H
A
A
F
MQ--G--P
Q
G
-
A
-
I
E
F
FHGYTYSG
H
P
V
A
C
A
A
A
L
A
T
L
D
I
Y
R
R
D
D
L
F
Q
R
A
V
E
-----
L
E
G
Y
W
Q
D
A
L
F
-
S
L
RDLP
N
V
V
D
I
R
A
V
G
L
VG
G
V
---------
Q
--LAPHADGP----GKR
G
---
Y
D
V
F
E
R
C
F
WEH
D
L
M
V
R
V
T-G-
D
I
I
AMSP
P
L
I
IDKP
H
I
D
Q
I
-------
V
E
R
L
A
Q
A
I
RASV
23
PsiBlast_CBE
95.05
50%
-114
- C1 -
4BQ0
4
BAUA_PSEAE
B:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
21
PsiBlast_CBE
94.99
50%
-111
- C1 -
4BQ0
4
BAUA_PSEAE
D:
[14-445]
----------
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
2
PsiBlast_PDB
94.65
50%
-112
- C1 -
4B9B
6
BAUA_PSEAE
A:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
3
PsiBlast_PDB
94.58
50%
-110
- C1 -
4BQ0
4
BAUA_PSEAE
A:
[10-445]
------
P
V
S
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
28
PsiBlast_CBE
94.36
50%
-113
- C1 -
4B9B
4
BAUA_PSEAE
D:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
1
PsiBlast_PDB
94.16
50%
-109
- C1 -
4B98
6
BAUA_PSEAE
A:
[10-445]
------
P
V
S
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
24
PsiBlast_CBE
94.08
50%
-111
- C1 -
4B9B
12
BAUA_PSEAE
H:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
29
PsiBlast_CBE
94.03
50%
-111
- C1 -
4B9B
8
BAUA_PSEAE
C:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
31
PsiBlast_CBE
93.83
50%
-109
- C1 -
4B98
6
BAUA_PSEAE
D:
[10-445]
------
P
V
S
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
33
PsiBlast_CBE
93.75
50%
-112
- C1 -
4B98
6
BAUA_PSEAE
B:
[10-445]
------
P
V
S
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
32
PsiBlast_CBE
93.67
50%
-109
- C1 -
4B98
6
BAUA_PSEAE
C:
[10-445]
------
P
V
S
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
26
PsiBlast_CBE
93.38
50%
-110
- C1 -
4B9B
3
BAUA_PSEAE
F:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
22
PsiBlast_CBE
93.38
50%
-110
- C1 -
4BQ0
4
BAUA_PSEAE
C:
[14-445]
----------
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
27
PsiBlast_CBE
93.32
50%
-109
- C1 -
4B9B
6
BAUA_PSEAE
E:
[14-445]
----------
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
30
PsiBlast_CBE
93.02
50%
-112
- C1 -
4B9B
5
BAUA_PSEAE
B:
[14-445]
----------
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
4
PsiBlast_PDB
92.54
48%
-108
- C1 -
3A8U
1
OAPT_PSEPU
X:
[15-445]
----------
K
L
D
--
A
H
W
M
P
Y
T
A
N
R
N
F
--
L
R
D
P
R
L
I
V
A
A
E
G
S
W
L
V
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
T
R
K
E
I
Q
E
A
V
A
K
Q
L
S
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
T
D
L
T
P
G
N
-
L
N
H
V
F
F
T
D
S
G
S
E
C
A
L
T
A
V
K
M
V
R
A
Y
W
R
L
K
G
Q
A
T
K
T
K
M
I
G
R
A
R
G
Y
H
G
V
N
I
A
G
T
S
L
G
G
V
N
G
N
---------
R
K
L
F
-
G
Q
P
-
M
Q
D
V
D
H
L
P
H
T
L
-
L
A
S
N
A
Y
S
-
R
G
M
P
K
E
G
-
G
I
A
L
A
D
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
F
V
E
P
L
-
A
G
S
A
G
V
L
V
P
P
E
G
Y
L
K
R
N
R
E
I
C
N
Q
H
N
I
L
L
V
F
D
E
V
I
T
G
F
G
R
T
G
S
M
F
G
A
D
S
-
F
G
V
T
P
D
L
M
C
I
A
K
Q
V
T
N
G
A
I
P
M
G
A
V
I
A
S
T
E
I
Y
Q
T
F
M
N
QP
T
--
P
E
Y
-
A
-
V
E
F
P
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
C
L
L
Q
K
E
N
L
V
Q
S
V
A
E
-----
V
A
P
H
F
E
K
A
L
H
-
G
I
K
G
A
K
N
V
I
D
I
R
N
F
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
A
----
I
V
R
P
---
F
E
A
-
G
M
A
L
W
K
A
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
S
K
P
Q
D
L
D
R
L
-------
F
D
A
V
G
E
V
L
N
---
25
PsiBlast_CBE
91.82
50%
-109
- C1 -
4B9B
12
BAUA_PSEAE
G:
[13-445]
---------
S
E
L
N
LR
A
H
W
M
P
F
S
A
N
R
N
F
--
Q
K
D
P
R
I
I
V
A
A
E
G
S
W
L
T
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
S
R
K
E
I
Q
E
A
V
A
R
Q
L
G
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
A
G
L
L
P
G
E
-
L
N
H
V
F
F
T
G
S
G
S
E
C
A
D
T
S
I
K
M
A
R
A
Y
W
R
L
K
G
Q
P
Q
K
T
K
L
I
G
R
A
R
G
Y
H
G
V
N
V
A
G
T
S
L
G
G
I
G
G
N
---------
R
K
M
F
G
Q
---
L
M
D
V
D
H
L
P
H
T
L
Q
P
G
M
-
A
F
T
-
R
G
M
A
-
Q
T
G
G
V
E
L
A
N
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
I
V
E
P
M
-
S
G
S
A
G
V
L
V
P
P
V
G
Y
L
Q
R
L
R
E
I
C
D
Q
H
N
I
L
L
I
F
D
E
V
I
T
A
F
G
R
L
G
T
Y
S
G
A
E
Y
-
F
G
V
T
P
D
L
M
N
V
A
K
Q
V
T
N
G
A
V
P
M
G
A
V
I
A
S
S
E
I
Y
D
T
F
M
N
--
Q
AL
P
E
H
-
A
-
V
E
F
S
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
D
I
L
A
R
D
N
L
V
Q
Q
S
A
E
-----
L
A
P
H
F
E
K
G
L
H
-
G
L
Q
G
A
K
N
V
I
D
I
R
N
C
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
P
----
T
V
R
P
---
F
E
A
G
M
K
-
L
W
Q
Q
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
A
R
P
E
E
L
D
R
L
-------
F
D
A
V
G
E
A
L
N
---
84
HHSearch
91.37
48%
-105
- C1 -
3A8U
1
OAPT_PSEPU
X:
[14-447]
---------
L
K
L
D
--
A
H
W
M
P
Y
T
A
N
R
N
F
L-
R
D
-
P
R
L
I
V
A
A
E
G
S
W
L
V
D
D
K
G
R
K
V
Y
D
S
L
S
G
L
W
T
C
G
A
G
H
T
R
K
E
I
Q
E
A
V
A
K
Q
L
S
T
L
D
-
Y
S
P
G
F
Q
Y
G
H
P
L
S
F
Q
L
A
E
K
I
T
D
L
T
-
P
G
N
L
N
H
V
F
F
T
D
S
G
S
E
C
A
L
T
A
V
K
M
V
R
A
Y
W
R
L
K
G
Q
A
T
K
T
K
M
I
G
R
A
R
G
Y
H
G
V
N
I
A
G
T
S
L
G
G
V
N
G
N
---------
R
K
L
F
-
G
Q
P
-
M
Q
D
V
D
H
L
P
H
T
L
L
A
-
S
N
A
Y
S
R
G
M
P
K
-
E
G
-
G
I
A
L
A
D
E
-----
L
L
K
L
I
E
L
H
D
A
S
N
I
A
A
V
F
V
E
P
L
-
A
G
S
A
G
V
L
V
P
P
E
G
Y
L
K
R
N
R
E
I
C
N
Q
H
N
I
L
L
V
F
D
E
V
I
T
G
F
G
R
T
G
S
M
F
G
A
D
S
-
F
G
V
T
P
D
L
M
C
I
A
K
Q
V
T
N
G
A
I
P
M
G
A
V
I
A
S
T
E
I
Y
Q
T
F
M
N
--
Q
--
P
T
P
E
Y
A
V
E
F
P
H
G
Y
T
Y
S
A
H
P
V
A
C
A
A
G
L
A
A
L
C
L
L
Q
K
E
N
L
V
Q
S
V
A
E
-----
V
A
P
H
F
E
K
A
L
H
G
I
K
G
A
-
K
N
V
I
D
I
R
N
F
G
L
A
G
A
I
---------
Q
--
I
A
P
R
D
G
D
A
----
I
V
R
P
---
F
E
A
G
M
A
L
W
K
-
A
G
F
Y
V
R
F
G
-
G
-
D
T
L
Q
F
G
P
T
F
N
S
K
P
Q
D
L
D
R
L
-------
F
D
A
V
G
E
V
L
N
K
L
-
75
HHSearch
80.30
37%
-102
- C1 -
3I5T
2
?
A:
[14-454]
------
V
G
A
A
M
R
D
--
H
I
L
L
P
A
Q
E
M
A
K
L
GK
S
A
-
Q
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
D
G
R
R
L
I
D
G
P
A
G
M
W
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
-
Y
A
S
P
W
Y
M
A
T
S
P
A
A
R
L
A
E
K
I
A
T
L
T
-
P
G
D
L
N
R
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
G
N
---------
W
P
N
F
-
D
I
A
-
Q
D
R
I
S
F
L
S
S
P
N
P
R
-
H
A
G
-
N
-
R
S
Q
E
-
A
F
-
L
D
D
L
V
Q
E
-----
F
E
D
R
I
E
S
L
G
P
D
T
I
A
A
F
L
A
E
P
I
-
L
A
S
G
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
K
V
F
G
V
V
P
D
I
I
T
F
A
K
G
V
T
S
G
Y
V
P
L
G
G
L
A
I
S
E
A
V
L
A
R
I
S
G
--
E
--
N
A
K
-
G
-
S
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
E
G
I
V
D
Q
A
R
E
-----
M
A
D
Y
F
A
A
A
L
A
S
L
R
-
D
L
P
G
V
A
E
T
R
S
V
G
L
V
G
C
V
---------
Q
--
C
L
L
D
---
G
T
A
E
D
K
A
F
T
---
L
K
I
D
E
R
C
F
E
-
L
G
L
I
V
R
P
L
-
G
-
D
L
C
V
I
S
P
P
L
I
I
S
R
A
Q
I
D
E
M
-------
V
A
I
M
R
Q
A
I
T
E
V
-
5
PsiBlast_PDB
79.76
39%
-111
- C1 -
3I5T
2
?
A:
[34-451]
-----------------------------
K
S
A
Q
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
D
G
R
R
L
I
D
G
P
A
G
M
W
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
-
Y
A
S
P
W
Y
M
A
T
S
P
A
A
R
L
A
E
K
I
A
T
L
T
P
G
D
-
L
N
R
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
G
N
WPNFDIAQD
R
I
S
F
L
S
S
P
-
N
P
-----
R
H
A
G
N
R
S
Q
E
A
F
L
-
D
D
L
---------
V
Q
E
-----
F
E
D
R
I
E
S
L
G
P
D
T
I
A
A
F
L
A
E
P
I
-
L
A
S
G
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
K
V
F
G
V
V
P
D
I
I
T
F
A
K
G
V
T
S
G
Y
V
P
L
G
G
L
A
I
S
E
A
V
L
A
R
I
S
G
--
E
--
N
A
K
-
G
-
S
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
E
G
I
V
D
Q
A
R
E
-----
M
A
D
Y
F
A
A
A
L
A
-
S
L
R
D
L
P
G
V
A
E
T
R
S
V
G
L
V
G
C
V
---------
Q
C
L
L
D
----
G
T
----
A
E
D
K
A
F
T
L
K
I
D
E
R
C
F
-
E
L
G
L
I
V
R
P
L
-
G
-
D
L
C
V
I
S
P
P
L
I
I
S
R
A
Q
I
D
E
M
-------
V
A
I
M
R
Q
A
I
----
7
PsiBlast_PDB
76.30
35%
-102
- C1 -
4A6R
2
?
A:
[34-455]
---------------------------------
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
-
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
---------
H
-----
D
L
P
I
P
G
M
A
H
I
E
Q
P
W
-
W
Y
K
H
G
K
D
-
M
T
P
D
-
E
F
-
G
V
V
A
A
R
W
-----
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
-
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
--
G
--
G
------
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
----
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
KNKAKR
E
--
L
F
P
D
F
G
E
I
----
G
T
L
C
---
R
D
I
F
F
R
----
N
N
L
I
M
R
A
C
-
G
-
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
A
--
35
PsiBlast_CBE
75.23
35%
-98
- C1 -
4BA5
2
?
B:
[33-455]
--------------------------------
A
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
-
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
---------
H
E
--
Q
G
D
L
P
I
P
G
M
A
H
I
E
Q
P
W
-
W
Y
K
H
G
K
D
-
M
T
P
D
-
E
F
-
G
V
V
A
A
R
W
-----
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
-
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
--
G
--
G
------
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
DIGPY
M
Q
K
R
W
R
E
----
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
TLVKNKAKR
E
--
L
F
P
D
F
G
E
I
----
G
T
L
C
---
R
D
I
F
F
R
----
N
N
L
I
M
R
A
C
-
G
-
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
LAVAERC
L
E
E
F
E
Q
T
L
K
A
--
45
PsiBlast_CBE
75.17
35%
-102
- C1 -
4A6R
2
?
B:
[34-455]
---------------------------------
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
E
G
N
K
I
I
D
G
M
A
G
L
W
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
Y
N
T
F
F
K
T
T
H
P
A
V
V
E
L
S
S
L
L
A
E
V
T
P
A
G
-
F
D
R
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
M
---------
H
------
L
P
I
P
G
M
A
H
I
E
Q
P
W
-
W
Y
K
H
G
K
D
-
M
T
P
D
-
E
F
-
G
V
V
A
A
R
W
-----
L
E
E
K
I
L
E
I
G
A
D
K
V
A
A
F
V
G
E
P
I
-
Q
G
A
G
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
H
-
F
G
F
Q
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
G
L
I
A
--
G
--
G
------
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
Y
M
Q
K
R
W
R
E
----
T
F
S
R
F
E
H
V
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
KNKAKR
E
--
L
F
P
D
F
G
E
I
----
G
T
L
C
---
R
D
I
F
F
R
----
N
N
L
I
M
R
A
C
-
G
-
D
H
I
V
S
A
P
P
L
V
M
T
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
K
A
--
91
HHSearch
72.08
35%
-116
* C1 *
1VEF
2
ARGD_THET8
A:
[26-395]
-----------------------------
K
H
-
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
-
A
M
P
Q
T
-
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
-
P
P
E
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
-
L
P
L
-
V
E
P
V
E
F
I
P
---------
Y
N
------------
D
V
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
-------------
G
G
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
A
I
P
S
--
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
E
K
A
--------------
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
G
P
-
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
A
V
R
A
V
L
A
---
72
PsiBlast_CBE
69.57
31%
-106
- C1 -
1MGV
5
BIOA_ECOLI
A:
[31-421]
-------------------------------------
S
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
-
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
---------
M
H
S
L
W
K
G
Y
-
L
P
------------
E
N
L
F
A
-
P
A
P
Q
-
S
R
-
M
D
G
E
W
D
E
RDM
V
G
F
A
R
L
M
A
A
H
R
H
E
-
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
--
G
--
E
A
G
-
C
---
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
-----
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
---------
E
--
T
T
H
P
V
N
-------------
M
A
A
L
Q
K
F
F
V
E
Q
G
V
W
I
A
P
F
-
G
-
K
L
I
Y
L
M
P
P
Y
I
I
----
L
P
Q
Q
-------
L
Q
R
L
T
A
A
V
N
R
A
V
71
PsiBlast_CBE
69.50
31%
-105
- C1 -
1MGV
7
BIOA_ECOLI
B:
[31-421]
-------------------------------------
S
A
E
G
C
E
L
I
L
S
D
G
R
R
L
V
D
G
M
S
S
W
W
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
-
H
V
M
F
G
G
I
T
H
A
P
A
I
E
L
C
R
K
L
V
A
M
T
P
Q
P
-
L
E
C
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
A
-
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
S
---------
M
H
S
L
W
K
G
Y
-
L
P
------------
E
N
L
F
A
-
P
A
P
Q
-
S
R
-
M
D
G
E
W
D
E
RDMVG
F
A
R
L
M
A
A
H
R
H
E
-
I
A
A
V
I
I
E
P
I
V
Q
G
A
G
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
H
-
A
E
I
A
P
D
I
L
C
L
G
K
A
L
T
G
G
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
I
S
N
--
G
--
E
A
G
-
C
---
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
D
-----
I
E
V
Q
L
R
E
Q
L
A
-
P
A
R
D
A
E
M
V
A
D
V
R
V
L
G
A
I
G
V
V
---------
E
--
T
T
H
P
V
N
-------------
M
A
A
L
Q
K
F
F
V
E
Q
G
V
W
I
A
P
F
-
G
-
K
L
I
Y
L
M
P
P
Y
I
I
----
L
P
Q
Q
-------
L
Q
R
L
T
A
A
V
N
R
A
V
51
PsiBlast_CBE
69.07
33%
-114
- C1 -
1WKH
2
ARGD_THET8
B:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--
55
PsiBlast_CBE
68.98
33%
-115
- C1 -
1VEF
2
ARGD_THET8
B:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--
54
PsiBlast_CBE
68.78
33%
-115
- C1 -
1WKG
2
ARGD_THET8
A:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--
52
PsiBlast_CBE
68.63
33%
-113
- C1 -
1WKH
2
ARGD_THET8
A:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--
56
PsiBlast_CBE
68.39
33%
-115
- C1 -
1VEF
2
ARGD_THET8
A:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--
53
PsiBlast_CBE
67.16
33%
-111
- C1 -
1WKG
2
ARGD_THET8
B:
[44-392]
------------------------------------------------
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
--
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
-
L
N
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
H
T
------
G
R
K
K
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
W
E
P
K
Y
---------
R
E
P
F
L
P
L
V
-
E
P
-
V
E
F
I
P
Y
N
-
D
V
--------------------
E
A
-----
L
K
R
A
V
D
----
E
E
T
A
A
V
I
L
E
P
V
-
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
-
F
G
I
V
P
D
I
L
T
L
A
K
A
L
-
G
G
G
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
-------
P
K
G
-
G
-----
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
R
L
W
E
R
A
A
E
-----
L
G
P
W
F
M
E
K
L
R
-
A
I
P
S
-
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
---------
E
--
L
K
-----------
E
K
A
---
A
P
Y
I
A
R
L
E
K
E
H
R
V
L
A
L
Q
A
-
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
-------
V
E
----
A
V
R
A
--