@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA5366: (2016-03-06 )
MQNETASHGINFDALGRDRQSLDLASESVELEVPGLNLFYGAKQALFDVRMNIPKQRVTAFIGPSGCGKSTLLRCFNRMNDLVDGCRVEGEIRLDGHNIFAKGVDVAELRRRVGMVFQKPNPFPKSIYENVVYGLRIQGINKKRVLDEAVEWALKGAALWEEVKDRLHESALGLSGGQQQRLVIARTIAVEPEVLLLDEPCSALDPISTLKIEELIYELKSKFTIVIVTHNMQQAARVSDYTAFMYMGKLIEFGDTDTLFTNPAKKQTEDYITGRYG
Atome Classification :
(46 SA)
.........10........20........30........40.----.....---..50........60........70.....-------...80.....---...90.....-------------...-----------100-----------.-......----110.......120....-....130..------.--...-.140---........---.--150.......160.--------..-------....170.......180.......190........200.......210-.......--220..--.-......230.......240.....-..250.......260...-....270.....---------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQNETASHGI
N
F
D
ALGRD
R
Q
SLDLASE
S
V
E
L
EVPG
L
N
L
F
Y
G
A
----
K
Q
A
L
F
---
D
V
R
MNI
P
K
Q
R
V
T
A
F
IGPSGC
G
K
S
T
L
L
R
C
F
-------
N
R
M
N
D
L
V
D
GC---RV
E
G
E
I
R
LDG-------------H
N
I
-----------
F
AK-----------G-V
D
V
A
E
L
----
R
R
RVG
M
V
FQKPN-PF
P
K
-
S
I
Y
E
NV
V
Y
G
------
L
--
R
I
Q-GI-----
N
K
K
R
V
L
D
E
---
A
--
V
E
W
A
L
K
G
A
A
L
W
E
E
V
--------
K
D
-------
R
L
H
E
S
ALGLSGGQ
Q
Q
R
L
V
I
A
R
T
IAV-EP
E
V
L
L
LDEPCSALDP
I
S
T
L
K
I
-
E
E
L
I
Y
E
L
--K--S
K
--
F
-
T
I
V
I
V
TH
N
M
Q
Q
A
A
R
V
S
D
Y
T
A
F
M
Y
M
-
G
K
L
IEFGDTDTLFTNPAK-K
Q
T
E
D
YITGRYG---------------------------------------------------------------------------------------------
124
HHSearch
87.92
37%
-104
- C1 -
1B0U
4
HISP_SALTY
A:
[5-255]
----------------------------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
----
H
E
V
L
K
---
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
-------
N
F
L
E
K
P
--------
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
-----------
N
L
V
R
D
KDGQLKVAD
K
-
N
Q
L
R
L
L
----
R
T
R
L
T
M
V
F
Q
H
F
N
-
L
W
S
H
M
T
V
L
E
N
V
M
E
A
------
P
--
I
Q
V
L
G
L
-----
S
-
K
H
D
A
R
E
---
R
--
A
L
K
Y
L
A
K
V
G
I
D
E
R
------------------
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
--
A
E
-
E
G
--
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
K
G
------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
86.35
33%
-106
* C1 *
1B0U
4
HISP_SALTY
A:
[6-255]
-----------------------------
K
L
H
V
I
D
L
H
K
R
Y
G
G
----
H
E
V
L
K
---
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
-------
N
F
L
E
K
--------
P
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
V
R
D
KDGQLK
V
A
D
-----------
K
-
N
Q
L
R
L
L
----
R
T
R
L
T
M
V
F
Q
H
F
N
-
L
W
S
H
M
T
V
L
E
N
V
M
E
A
P-----
I
--
Q
V
L
-
G
L
-----
S
K
H
D
A
R
E
R
---
A
--
L
K
Y
L
A
K
-
V
G
I
D
E
R
A
--------
Q
G
-------
K
Y
---
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
--
A
--
E
E
G-
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
-
P
R
L
Q
Q
F
L
K
G
------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
84.00
34%
-108
- C1 -
4U00
3
?
A:
[5-238]
------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
--------
E
G
E
V
V
V
D
G
-------------
L
S
V
------------
K
D
-----------
D
-
R
A
L
R
E
I
----
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
-----
M
--
R
V
R
-
R
W
-----
P
R
E
K
A
E
K
K
---
A
--
L
E
L
L
E
R
V
G
I
L
-------------
D
-------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
-
Q
--
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
83.53
34%
-104
- C1 -
4U02
1
?
C:
[5-238]
------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
--------
E
G
E
V
V
V
D
G
-------------
L
S
V
------------
K
D
-----------
D
-
R
A
L
R
E
I
----
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P-----
M
--
R
V
R
-
R
W
-----
P
R
E
K
A
E
K
K
---
A
--
L
E
L
L
E
R
V
G
I
L
-------------
D
-------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A-
Q
--
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
83.51
34%
-105
- C1 -
4U02
1
?
B:
[5-238]
------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
--------
E
G
E
V
V
V
D
G
-------------
L
S
V
------------
K
D
-----------
D
-
R
A
L
R
E
I
----
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P-----
M
--
R
V
R
-
R
W
-----
P
R
E
K
A
E
K
K
---
A
--
L
E
L
L
E
R
V
G
I
L
-------------
D
-------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A-
Q
--
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------
110
HHSearch
83.02
32%
-110
- C1 -
3TUI
1
METN_ECOLI
C:
[23-264]
----------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
GTRT
I
Q
A
L
N
---
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
-------
N
L
L
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
-----------
T
T
L
-----------
S
E
S
E
L
T
K
A
----
R
R
Q
I
G
M
I
F
Q
H
F
N
-
L
L
S
S
R
T
V
F
G
N
V
A
L
P
------
L
--
E
L
D
-
N
T
-----
P
K
-
D
E
V
K
R
---
R
--
V
T
E
L
L
S
L
V
G
L
G
------------
D
-------
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
--
N
RR
L
G
--
L
-
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
-
P
L
A
Q
K
F
I
--------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
82.11
34%
-105
- C1 -
4U02
1
?
A:
[5-238]
------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
--------
E
G
E
V
V
V
D
G
-------------
L
S
V
------------
K
D
-----------
D
-
R
A
L
R
E
I
----
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P-----
M
--
R
V
R
-
R
W
-----
P
R
E
K
A
E
K
K
---
A
--
L
E
L
L
E
R
V
G
I
L
-------------
D
-------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A
-
Q
--
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------
129
Fugue
81.82
31%
-99
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
-----------------
R
T
----
I
Q
A
L
N
---
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
-------
N
L
L
E
R
P
T
--------
E
G
S
V
L
V
D
G
-------------
Q
E
L
T----------
T
L
S
-----------
E
-
S
E
L
T
K
A
----
R
R
Q
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
-
T
V
F
G
N
V
A
L
P
------
L
--
E
L
D
-
N
T
-----
P
K
-----
D
---
E
--
V
K
R
R
V
T
E
L
L
S
L
V
G
L
--------
G
D
-------
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
--
N
--
R
R
LG
L
-
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
-
P
L
A
Q
K
F
I
Q
S
T
L
H
LDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
33
PsiBlast_CBE
81.22
34%
-102
- C1 -
4U02
1
?
D:
[5-238]
------------------------------
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
---
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
-------
N
R
L
E
D
F
Q
--------
E
G
E
V
V
V
D
G
-------------
L
S
V
------------
K
D
-----------
D
-
R
A
L
R
E
I
----
R
R
E
V
G
M
V
F
Q
Q
F
N
-
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P-----
M
--
R
V
R
-
R
W
-----
P
R
E
K
A
E
K
K
---
A
--
L
E
L
L
E
R
V
G
I
L
-------------
D
-------
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
D
V
M
R
D
L
A-
Q
--
G
G
--
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
-
E
R
T
R
S
F
L
--------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.23
36%
-105
- C1 -
4YMU
2
?
J:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.23
36%
-103
- C1 -
4YMT
-
?
J:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
137
Fugue
79.87
35%
-108
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
----------------------------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
-------
H
E
VLK
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
FLEKPS---------------
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
-----------
D
K
N
-----------
Q
-
L
R
L
L
R
T
-----
R
-
L
T
M
V
F
Q
H
F
N
-
L
W
S
H
M
T
V
L
E
N
V
M
E
A
------
P
--
I
Q
V
-
L
--------------GLS
K
--
H
D
A
R
E
R
A
L
K
Y
L
A
K
V
GIDERAQG------------
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
-
L
R
I
M
Q
Q
L
--
A
--
E
E
G-
K
-
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
P
R
L
Q
Q
F
L
K
G
S
L
K
KLE------------------------------------------------------------------------------------------
1
PsiBlast_PDB
79.71
35%
-106
- C1 -
3C41
3
?
J:
[4-239]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
79.28
35%
-113
- C1 -
3C4J
4
?
B:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
79.25
35%
-109
- C1 -
2OLK
2
?
B:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
79.17
36%
-106
- C1 -
4YMW
-
?
J:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.12
36%
-105
- C1 -
4YMS
-
?
J:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.88
35%
-110
- C1 -
2OLJ
4
?
A:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
78.83
36%
-103
- C1 -
4YMU
2
?
A:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.59
36%
-102
- C1 -
4YMV
1
?
J:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
78.55
35%
-110
- C1 -
2OLK
1
?
D:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
78.26
36%
-102
- C1 -
4YMV
1
?
A:
[11-237]
---------------------------------------
F
G
S
----
L
E
V
L
K
---
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
-------
N
L
L
E
E
--------
P
T
K
G
E
V
F
I
D
G
-------------
V
K
I
-----------
N
N
G
-----------
K
-
V
N
I
N
K
V
----
R
Q
K
V
G
M
V
F
Q
H
F
N
-
L
F
P
H
L
T
A
I
E
N
I
T
L
A
P-----
V
--
K
V
K
-
K
M
-----
N
K
K
E
A
E
E
L
---
A
--
V
D
L
L
A
K
V
G
L
L
-------------
D
-------
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
-
L
N
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
-
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
78.04
35%
-108
- C1 -
3C41
3
?
K:
[4-239]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
77.71
35%
-107
- C1 -
2OLK
1
?
C:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
77.50
35%
-106
- C1 -
3C4J
3
?
A:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.63
35%
-104
- C1 -
2Q0H
4
?
A:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P
-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
76.52
35%
-103
- C1 -
2OLJ
3
?
B:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
75.95
35%
-107
- C1 -
2OLK
1
?
A:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
74.46
35%
-108
- C1 -
2Q0H
4
?
B:
[25-260]
------------------------------
I
D
V
H
Q
L
K
K
S
F
G
S
----
L
E
V
L
K
---
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
-------
N
L
L
E
D
F
D
--------
E
G
E
I
I
I
D
G
-------------
I
N
L
-----------
K
A
K
-----------
D
-
T
N
L
N
K
V
----
R
E
E
V
G
M
V
F
Q
R
F
N
-
L
F
P
H
M
T
V
L
N
N
I
T
L
A
P-----
M
--
K
V
R
-
K
W
-----
P
R
E
K
A
E
A
K
---
A
--
M
E
L
L
D
K
V
G
-----
L
--------
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
-
L
S
V
M
K
Q
L
--
A
--
N
E
G-
M
-
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
-
E
R
T
K
A
F
L
S
-------------------------------------------------------------------------------------------------
89
PsiBlast_CBE
70.29
35%
-111
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[20-236]
-------------------------------------------------
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
-------
A
G
F
E
Q
--------
P
D
S
G
E
I
S
L
S
G
-------------
K
T
I
-----------
F
S
K
-----------
N
-
T
N
L
P
V
R
----
E
R
R
L
G
Y
L
V
Q
E
G
V
-
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
------
L
------
G
N
-----
G
K
G
R
T
A
Q
E
---
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
L
A
--------
G
R
-------
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
--
R
--
A
N
--
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-----------------------------------------------------------------------------------------------------------
88
PsiBlast_CBE
68.97
35%
-111
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[20-231]
-------------------------------------------------
L
N
---
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
-------
A
G
F
E
Q
--------
P
D
S
G
E
I
S
L
S
G
-------------
K
T
I
-----------
F
S
K
-----------
N
-
T
N
L
P
V
R
----
E
R
R
L
G
Y
L
V
Q
E
G
V
-
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
------
L
------
G
N
-----
G
K
G
R
T
A
Q
E
---
R
QR
I
E
A
M
L
E
L
T
G
I
S
E
L
A
--------
G
R
-------
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
--
R
--
A
N
--
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
-
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-----------------------------------------------------------------------------------------------------------
104
PsiBlast_CBE
68.90
34%
-118
- C1 -
1L2T
4
Y796_METJA
A:
[20-223]
------------------------------------------------
A
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
---------------
G
C
LDK
P
T
E
G
E
V
Y
I
D
---------------
N
I
-----------
K
T
N
-----------
D
-
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
IF
K
Y
R
-
G
A
M
S
G
E
E
R
R
K
R
A
L
E
----------
C
L
K
M
A
E
L
E
E
R
F
--------
A
N
-------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
--
N
--
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------------------------------------------------------------------------------------------------
103
PsiBlast_CBE
68.45
34%
-120
- C1 -
1L2T
4
Y796_METJA
B:
[20-223]
------------------------------------------------
A
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
---------------
G
C
LDK
P
T
E
G
E
V
Y
I
D
---------------
N
I
-----------
K
T
N
-----------
D
-
L
D
D
D
E
L
TKIR
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
IF
K
Y
R
-
G
A
MSGEE
R
R
K
R
A
L
E
----------
C
L
K
M
A
E
L
E
E
R
F
--------
A
N
-------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
--
N
--
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
68.20
34%
-116
- C1 -
3TIF
7
Y796_METJA
A:
[20-223]
------------------------------------------------
A
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
---------------
G
C
LDK
P
T
E
G
E
V
Y
I
D
---------------
N
I
-----------
K
T
N
-----------
D
-
L
D
D
D
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
IF
K
Y
R
-
G
A
M
S
G
E
E
R
R
K
R
A
L
E
----------
C
L
K
M
A
E
L
E
E
R
F
--------
A
N
-------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
--
N
--
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------------------------------------------------------------------------------------------------
105
PsiBlast_CBE
66.66
34%
-121
- C1 -
3TIF
6
Y796_METJA
B:
[20-223]
------------------------------------------------
A
L
K
---
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
---------------
G
C
LDK
P
T
E
G
E
V
Y
I
D
---------------
N
I
-----------
K
T
N
-----------
D
-
L
D
D
D
E
L
TKIR
R
D
K
I
G
F
V
F
Q
Q
F
N
-
L
I
P
L
L
T
A
L
E
N
V
E
L
P
------
L
IF
K
Y
R
-
G
A
MSGEE
R
R
K
R
A
L
E
----------
C
L
K
M
A
E
L
E
E
R
F
--------
A
N
-------
H
K
P
N
Q
---
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
-
M
Q
L
L
K
K
L
--
N
--
E
E
DG
K
-
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
-------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
61.13
31%
-118
- C1 -
1VCI
1
?
A:
[11-240]
----------------------------
V
E
V
K
L
E
N
L
T
K
R
F
G
N
----
F
T
A
V
N
---
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
-------
A
G
L
E
E
P
T
E
G
----------------------------
R
I
-----------
Y
F
G
-----------
D
-
R
D
V
T
Y
L
PPK-
D
R
N
I
S
M
V
F
Q
-------
H
M
T
V
Y
E
N
I
A
F
P
------
L
----
K
-
K
F
-----
P
K
D
E
I
-
D
K
---
R
--
V
R
W
A
----
A
E
L
L
Q
I
--------
E
E
-------
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
-
R
A
E
I
K
K
L
Q
Q
K
--
L
K
--
V
-
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
-
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
------------------------------------------------------------------------------------------------------------
95
PsiBlast_CBE
60.68
33%
-98
- C1 -
2ONJ
4
Y1866_STAAM
B:
[359-557]
------------------------------------------------------
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-------
P
R
F
Y
D
V
T
--------
S
G
Q
I
L
I
D
G
-------------
H
N
I
-------------
K
-----------
D
-
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
N
I
-
L
F
S
D
-
T
V
K
E
N
I
L
L
G
---------------------
R
P
T
A
T
D
E
---
E
--
V
V
E
A
A
K
M
A
N
A
H
D
F
I
--------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
--
S
--
K
D
--
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
---------------------------------------------------------------------------------------------------------------------
96
PsiBlast_CBE
60.52
33%
-97
- C1 -
2ONJ
4
Y1866_STAAM
A:
[359-557]
------------------------------------------------------
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-------
P
R
F
Y
D
V
T
--------
S
G
Q
I
L
I
D
G
-------------
H
N
I
-------------
K
-----------
D
-
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
N
I
-
L
F
S
D
-
T
V
K
E
N
I
L
L
G
---------------------
R
P
T
A
T
D
E
---
E
--
V
V
E
A
A
K
M
A
N
A
H
D
F
I
--------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
--
S
--
K
D
--
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
---------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
59.21
31%
-82
- C1 -
3NHB
3
A:
[63-277]
--------------------------------------
Y
A
D
-----
R
E
T
L
Q
---
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
-------
F
R
F
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
-------------
S
-----------
Q
-
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
-
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
------
R
--
V
T
A
-
G
N
-----
D
E
V
E
A
A
A
Q
---
A
--
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
--------
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
--
C
--
A
N
--
R
-
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
-
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--------------------------------------------------------------------------------------------------------------
97
PsiBlast_CBE
59.14
33%
-101
- C1 -
2HYD
3
Y1866_STAAM
B:
[359-557]
------------------------------------------------------
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-------
P
R
F
Y
D
V
T
--------
S
G
Q
I
L
I
D
G
-------------
H
N
I
-------------
K
-----------
D
-
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
N
I
-
L
F
S
D
-
T
V
K
E
N
I
L
L
G
---------------------
R
P
T
A
T
D
E
---
E
--
V
V
E
A
A
K
M
A
N
A
H
D
F
I
--------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
--
S
--
K
D
--
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
---------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
59.07
33%
-100
- C1 -
2HYD
3
Y1866_STAAM
A:
[359-557]
------------------------------------------------------
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-------
P
R
F
Y
D
V
T
--------
S
G
Q
I
L
I
D
G
-------------
H
N
I
-------------
K
-----------
D
-
F
L
T
G
S
L
----
R
N
Q
I
G
L
V
Q
Q
D
N
I
-
L
F
S
D
-
T
V
K
E
N
I
L
L
G
---------------------
R
P
T
A
T
D
E
---
E
--
V
V
E
A
A
K
M
A
N
A
H
D
F
I
--------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
-
Q
E
A
L
D
V
L
--
S
--
K
D
--
R
-
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
---------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
57.66
31%
-80
- C1 -
3NH9
3
A:
[63-277]
--------------------------------------
Y
A
D
G
----
R
E
T
L
Q
---
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
-------
F
R
F
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
-------------
S
-----------
Q
-
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
-
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
------
R
--
V
T
A
-
G
N
-----
D
E
V
E
A
A
A
Q
---
A
--
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
--------
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
--
C
--
A
N
--
R
-
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
-
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
57.39
31%
-81
- C1 -
3NHA
4
A:
[63-277]
--------------------------------------
Y
A
D
-----
R
E
T
L
Q
---
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
-------
F
R
F
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
-------------
S
-----------
Q
-
V
T
Q
A
S
L
----
R
S
H
I
G
V
V
P
Q
D
T
V
-
L
F
N
D
-
T
I
A
D
N
I
R
Y
G
------
R
--
V
T
A
-
G
N
-----
D
E
V
E
A
A
A
Q
---
A
--
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
--------
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
-
Q
A
S
L
A
K
V
--
C
--
A
N
--
R
-
T
T
I
V
V
A
H
R
L
S
T
V
V
N
-
A
D
Q
I
L
V
I
K
D
-
G
C
I
V
E
R
G
R
H
E
A
L
L
S
--------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
54.67
32%
-84
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[362-572]
------------------------------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
P
A
S
G
T
--------
I
S
L
D
G
-------------
H
D
I
-------------
R
-----------
Q
-
L
N
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
P
I
-
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
--
T
A
E
-
E
I
-----
Q
R
V
A
E
V
A
N
---
A
--
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
------------------
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
--
D
G
--
R
-
T
V
L
V
I
A
H
R
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
52.02
32%
-86
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[393-598]
------------------------------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
P
A
S
G
T
--------
I
S
L
D
G
-------------
H
D
I
-------------
R
-----------
Q
-
L
N
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
P
I
-
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
--
T
A
E
-
E
I
-----
Q
R
V
A
E
V
A
N
---
A
--
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
------------------
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
--
D
G
--
R
-
T
V
L
V
I
A
H
H
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
51.45
32%
-83
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[362-567]
------------------------------------------------------
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
-------
L
R
L
Y
D
P
A
S
G
T
--------
I
S
L
D
G
-------------
H
D
I
-------------
R
-----------
Q
-
L
N
P
V
W
L
----
R
S
K
I
G
T
V
S
Q
E
P
I
-
L
F
S
C
-
S
I
A
E
N
I
A
Y
G
ADDPSS
V
--
T
A
E
-
E
I
-----
Q
R
V
A
E
V
A
N
---
A
--
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
------------------
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
-
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
-
Q
E
A
L
D
R
L
--
M
--
D
G
--
R
-
T
V
L
V
I
A
H
R
L
-
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
-
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------