@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : D3E974_GEOS4: (2019-01-27 )
MLYTLGQKIGEGGCSEVFEVGDNRIIKLAKENTSFEALRREYLNNCIAWECGLPIPQPFELTKMSGRPGIVFEHIAGKTMMERFFNQVIVSHNNEVKQADVQLTAQLLFRVHQALAEGKELPCQKSIIKSNILSVNYLSASEKESAISLLESLETKQCLCHGDPNPRNVIVKDDGEAILLDWMNATIGNPEADIAEYIVMIRYAVLPSSFPEETRDMFDSIREDLIDIFIDEYYRLSGISYDDVVPWIIPILARKLSADAISDVEKKKLVAEIRRDLGKQKNRV
Atome Classification :
(23 SA)
-------------------..---....-----...10........20..-----------.-----.-----....-.30...-----.-----....-------.40-....-....-50.---..-......60-----...------.---.---..----..70......-..80.....-----------------...----90.......-.100...-...--------.110.--------------......--.----120--.---.--------...----..-------.---.-130-..------.---.----.-----.---..----.----140-----..-----------.---....----..150--.---.----.-------...------.-..160.......170------------------------...----.----.....180......-------------.190......------.200....------...210...----------....220-.---------......230-----------........---240........250.......260..----------.....270.......280----.--...--------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------ML---
Y
T
L
G
-----
Q
K
IGEG
G
C
S
E
V
F
E
V-GD-----------
N
-----
R
-----
I
I
K
L-AK-ENT-----
S
-----
F
E
A
L
-------
R
R
E
-
Y
L
N
N-
C
I
AW-E-C---GL-PIPQPF
E
------
L
TK------M---S---GR----P
G
I
V
F
E
H
IA
G
-
K
T
M
M
E
R
F
F
N
-----------------
Q
V
I
----
V
SHNNE
V
K
Q
-
A
D
V
Q
L
T
A
-
Q
L
L
--------
F
R
-
V
H
--------------
Q
A
L
AEG--K----E----L---
P
--------
C
Q
K
----
S
I
-------
I
---
K
-S---N
I
------
L
---
S
----
V
-----
N
---YL----S----A-------S
E
-----------
K
---
E
S
A
I
----
S
L
L
----
E
---S----L-------
E
T
K
------
Q
-
C
L
CHGDPNP
R
N
V
I
--------------------------VKD----D----G
E
A
I
L
L
D
W
M
N
ATIG-------------NP
E
A
D
I
A
E
Y
I
------
V
M
I
R
Y
A
VL------PSSF
P
E
E
T
R
----------
D
M
F
D
S
I
R
-
E
---------
D
L
I
D
I
F
I
D
------------
E
Y
Y
R
LSGI---
S
-
Y
D
D
V
V
P
W
I
I
P
I
L
A
R
K
LS
A
D
A
I
S
D
V
----------
E
K
K
K
L
V
A
E
I
R
R
D
L
G
KQ------K--NRV--------------------------------
69
Fugue
74.21
16%
9
- C3 -
-
4XHG
2
?
A:
[2-397]
--------------DLRVG
R
K
---
F
R
I
G
-----
R
K
I
G
S
G
S
F
G
D
I
Y
H
G
-
T
N
-----------
L
-----
I
SG
E
E
V
A
I
R
L
-
E
S
-
I
R
S
-----
R
-----
H
P
Q
L
-------
D
Y
E
S
R
V
Y
K
-
Y
L
S
G
-
G
-
V
---
G
I
-
P
F
I
R
W
F
G
--------
R
------
E
---
G
---
E
Y
----
N
A
M
V
I
D
L
L
G
P
-
S
--
L
E
D
L
F
N
-----------------
Y
C
----------------
H
R
K
F
S
F
-
K
T
V
--------
I
M
-
L
A
--------------
L
Q
M
I
C
R
--
V
----
Q
----
Y
---
I
--------
H
G
R
----
S
F
-------
I
---
H
-
R
---
D
I
------
K
---
P
----
D
-----
N
---
F
L
M
---
G
----
V
-------
G
R
-----------
R
---
G
S
T
V
----
H
V
I
----
D
---
F
----
G
-------
L
S
K
------
K
----
Y
R
D
F
N
T
H
R
H
I
P
Y
R
E
N
K
S
L
T
G
TARYAS
V
N
T
H
L
GIEQS
R
R
D
----
D
----
L
E
S
L
G
Y
M
L
I
Y
F
C
K
G
SLPWQGLKATT
K
K
Q
K
Y
D
R
I
L
E
K
K
------
L
C
I
S
V
E
T
L
------
C
A
G
L
P
L
E
F
S
----------
E
Y
M
N
Y
C
R
-
N
LKFDERPD
Y
L
Y
L
A
R
L
F
K
------------
D
L
S
I
K
L
E
Y
---
H
-
N
D
H
L
F
D
W
T
M
L
R
Y
T
K
A
M
V
E
K
K
N
D
S
F
----------
N
K
V
K
L
L
A
M
K
K
F
A
S
H
F
H
------
Y
--
C
K
N
DDKHYPT
P
E
E
I
K
Q
Q
T
V
Q
N
N
N
AAP
E
L
L
S
A
I
D
K-
70
Fugue
73.96
15%
34
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
-------------TDIT
E
D
E
L
---
R
N
F
L
-----
T
Q
Y
D
V
G
S
L
T
S
Y
K
G
I
-
A
E
-----------
N
-----
S
-----
N
F
L
L
-
H
T
-
T
K
D
-----
P
-----
L
I
L
T
L
Y
EKKN
D
L
P
F
-
F
L
G
L
M
Q
H
L
A
-
A
-
K
---
G
L
-
S
C
P
L
P
L
P
R
KDGEL
L
G
E
------
L
---
S
---
G
R
----
P
A
A
L
I
S
F
L
E
G
M
W
L
R
K
------------------------------
P
E
A
K
H
C
R
E
-
V
G
K
A
L
A
A
M
H
L
A
--------
S
E
G
F
E
--------------
I
K
R
P
N
A
--
L
----
S
----
V
---
D
--------
G
W
K
----
V
L
-------
W
---
D
-
K
---
S
E
------
E
---
R
----
A
-----
D
---
E
V
----
E
----
K
-------
G
L
-----------
R
---
E
E
I
R
----
P
E
I
----
D
---
Y
----
L
-------
A
A
H
WPKDLP
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
F
--------------------------
F
L
G
----
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
-------------
L
L
A
Y
D
V
S
I
C
L
------
N
A
W
C
F
E
K
D
------
G
A
Y
N
V
T
K
G
K
----------
A
L
L
E
G
Y
Q
-
S
---------
V
-
R
P
L
S
E
A
------------
E
L
E
A
L
P
L
L
---
S
-
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
A
G
A
L
V
----------
V
K
K
D
P
-
L
E
Y
L
R
K
L
R
F
H
------
R
--
T
I
A
NVAEYGLA------------------------
42
HHSearch
70.92
16%
-36
- C3 -
-
3ATT
2
Y3168_MYCTU
A:
[27-317]
---------------------------------
G
V
D
S
T
G
M
S
S
E
T
I
I
L
-
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
K
-----
L
-----
V
A
R
V
-
A
P
-
A
A
E
DVPVF
P
-----
T
Y
R
L
-------
D
H
Q
-
F
E
V
I
-
R
L
V
G
-
E
L
T
---
D
V
-
P
V
P
R
V
R
W
------
I
E
T
------
T
GDV
L
---
G
T
----
P
F
F
L
M
D
Y
V
E
G
-
V
V
P
P
D
V
M
P
Y
-----------------
T
F
G
DNWF
A
D
A
P
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
-
A
A
L
--------
A
T
-
L
H
--------------
S
I
P
N
A
Q
--
N
----
T
----
F
---
S
FLT-------
D
----
T
T
L
H
R
H
F
N
W
V
---
R
-
S
---
W
Y
------
D
---
F
----
A
-----
V
E
G
-
I
G
----
R
----
S
-------
P
L
-----------
L
---
E
R
T
F
----
E
W
L
----
Q
---
S
H
---
W
P
D
D
A
A
--
A
R
E
------
P
-
V
L
L
W
G
D
A
R
V
G
N
V
L
--------------------------
Y
R
D
----
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
-------------
P
R
E
L
D
V
A
W
M
I
------
F
A
H
R
V
F
Q
E
------
L
A
G
L
A
---
T
-----------
L
-
P
G
L
P
E
V
---------
M
R
E
D
D
V
R
A
------------
T
Y
Q
A
L
T
G
V
---
E
-
L
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
------------------------------------------------------------------------------
41
HHSearch
70.39
16%
-32
* C3 *
-
3ATS
1
Y3168_MYCTU
A:
[27-317]
---------------------------------
G
V
D
S
T
G
M
S
S
E
T
I
I
L
-
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
K
-----
L
-----
V
A
R
V
-
A
P
-
A
A
E
DVPVF
P
-----
T
Y
R
L
-------
D
H
Q
-
F
E
V
I
-
R
L
V
G
-
E
L
T
---
D
V
-
P
V
P
R
V
R
W
------
I
E
T
------
T
GDV
L
---
G
T
----
P
F
F
L
M
D
Y
V
E
G
-
V
V
P
P
D
V
M
P
Y
-----------------
T
F
G
DNWF
A
D
A
P
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
-
A
A
L
--------
A
T
-
L
H
--------------
S
I
P
N
A
Q
--
N
----
T
----
F
---
S
FLT-------
D
----
T
T
L
H
R
H
F
N
W
V
---
R
-
S
---
W
Y
------
D
---
F
----
A
-----
V
E
G
-
I
G
----
R
----
S
-------
P
L
-----------
L
---
E
R
T
F
----
E
W
L
----
Q
---
S
H
---
W
P
D
D
A
A
--
A
R
E
------
P
-
V
L
L
W
G
D
A
R
V
G
N
V
L
--------------------------
Y
R
D
----
F
----
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
-------------
P
R
E
L
D
V
A
W
M
I
------
F
A
H
R
V
F
Q
E
------
L
A
G
L
A
---
T
-----------
L
-
P
G
L
P
E
V
---------
M
R
E
D
D
V
R
A
------------
T
Y
Q
A
L
T
G
V
---
E
-
L
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
------------------------------------------------------------------------------
33
HHSearch
67.92
18%
-12
- C3 -
-
4H05
-
?
B:
[17-251]
--------------------------
W
V
-----
V
V
E
D
G
A
S
G
A
G
V
Y
R
L
-
R
G
GG
R
--------
E
-----
L
-----
F
V
K
V
-
A
A
-
L
G
A
-----------
G
V
G
L
-------
L
G
E
-
A
E
R
L
-
V
W
L
A
-
E
-
V
---
G
I
-
P
V
P
R
V
V
E
------
G
G
G
------
D
---
E
---
R
V
----
A
W
L
V
T
E
A
V
P
G
-
R
P
A
S
A
R
W
-----------------------------
P
R
E
Q
R
L
-
D
V
A
V
A
L
A
-
G
L
A
--------
R
S
-
L
H
--------------
A
L
D
W
E
R
--
C
----
P
----
F
---
D
RS
L
A
V
T
V
P
Q
A
A
----
R
A
-------
V
---
A
-
E
---
G
S
------
V
---
D
----
L
-----
E
---
D
L
DEER
K
----
G
-------
W
S
-----------
G
---
E
R
L
L
----
A
E
L
----
E
---
R
T
RP-
A
-------
D
E
D
------
L
-
A
V
C
H
G
D
L
C
P
D
N
V
L
--------------------------
L
D
P
----
R
TC--
E
V
T
G
L
I
D
V
G
R
V
G
R
A
-------------
D
R
H
S
D
L
A
L
V
L
------
R
E
L
A
H
E
E
D
------
P
----------------------
W
F
G
-
P
---------
E
C
S
A
A
F
L
R
------------
E
Y
G
R
G
W
D
G
---
A
-----------------------------------------------------------------------------------------------
37
HHSearch
66.89
16%
3
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[17-245]
-------------------------
R
C
V
-----
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
-
V
G
EN
E
--------
N
-----
L
-----
Y
L
K
M
-
T
D
-
S
R
Y
KG---
T
-----
T
Y
D
V
-------
E
R
E
-
K
D
M
M
-
L
W
L
E
-
G
-----
K
L
-
P
V
P
K
V
L
H
------
F
E
R
------
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
Y
---------------------------
E
-
D
E
Q
S
P
E
-
K
I
I
E
L
Y
A
-
E
C
I
--------
R
L
-
F
H
--------------
S
I
D
I
S
D
--
C
----
P
YTNS
L
---
D
--------
S
R
L
A
E
L
D
Y
L
-------
L
---
N
-
N
---
D
L
------
A
---
D
----
V
-----
D
CEN
W
E
----
E
DTP-
F
-------
K
D
-----------
P
---
R
E
L
Y
----
D
F
L
----
K
---
T
E
K--
P
-------
E
E
E
------
L
-
V
F
S
H
G
D
L
G
D
S
N
I
F
--------------------------
V
K
D
----
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
-------------
D
K
W
Y
D
I
A
F
C
V
------
R
S
I
R
E
D
I
G
-------------------------------
E
-
E
---------
Q
Y
V
E
L
F
F
D
------------
L
L
G
--------------------------------------------------------------------------------------------------------
38
HHSearch
66.41
16%
9
- C3 -
-
1L8T
2
KKA3_ENTFL
A:
[17-245]
-------------------------
R
C
V
-----
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
-
V
G
EN
E
--------
N
-----
L
-----
Y
L
K
M
-
T
D
-
S
R
Y
KG---
T
-----
T
Y
D
V
-------
E
R
E
-
K
D
M
M
-
L
W
L
E
-
G
-----
K
L
-
P
V
P
K
V
L
H
------
F
E
R
------
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
Y
---------------------------
E
-
D
E
Q
S
P
E
-
K
I
I
E
L
Y
A
-
E
C
I
--------
R
L
-
F
H
--------------
S
I
D
I
S
D
--
C
----
P
YTNS
L
---
D
--------
S
R
L
A
E
L
D
Y
L
-------
L
---
N
-
N
---
D
L
------
A
---
D
----
V
-----
D
CEN
W
E
----
E
DTP-
F
-------
K
D
-----------
P
---
R
E
L
Y
----
D
F
L
----
K
---
T
E
K--
P
-------
E
E
E
------
L
-
V
F
S
H
G
D
L
G
D
S
N
I
F
--------------------------
V
K
D
----
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
-------------
D
K
W
Y
D
I
A
F
C
V
------
R
S
I
R
E
D
I
G
-------------------------------
E
-
E
---------
Q
Y
V
E
L
F
F
D
------------
L
L
G
--------------------------------------------------------------------------------------------------------
57
SP3
66.35
13%
0
- C- -
-
1F3M
-
?
C:
[1-294]
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
---
Y
T
R
F
-----
E
K
I
G
Q
G
A
S
G
T
V
Y
T
A
-
M
D
-----------
V
ATG
Q
E
V
-----
A
I
R
Q
-
M
N
-
L
Q
Q
-----
Q
PK---
K
E
L
I
-------
I
N
E
-
I
L
V
M
-
R
E
N
K
-
N
------
P
-
N
I
V
N
Y
L
D
------
S
Y
L
------
V
---
G
---
D
E
----
L
W
V
V
M
E
Y
L
A
G
-
G
S
L
T
D
V
V
T
E
-----------------
T
C
M
----
D
---
E
G
Q
I
A
-
A
V
C
R
E
C
L
-
Q
A
L
--------
E
F
-
L
H
--------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
--------------------------
L
G
M
----
D
----
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
-------------
T
-----------------
T
M
V
G
T
P
------
Y
W
M
A
P
E
V
V
T
----------
R
K
A
Y
G
P
K
-
V
---------
D
I
W
S
L
G
I
M
------------
A
I
E
M
I
E
G
------
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
P
E
L
----------
Q
N
P
E
K
L
S
A
I
F
R
D
F
L
N
R
CLDMDV
E
--
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
KIAKPLS
S
L
T
P
L
I
A
A
A
K
EATK
60
Fugue
65.60
15%
20
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
----KTPL
Y
E
T
L
N
E
S
S
A
V
A
L
A
---
V
K
L
G
LT
L
T
C
Q
E
I
G
D
G
N
L
N
Y
V
F
H
I
Y
D
R
-----------
A
-----
L
-----
I
I
K
Q
-
A
V
-
P
Y
W
-----
P
-----
L
T
I
D
-------
R
A
R
-
I
E
S
S
-
A
L
I
R
-
Q
-
G
---
E
H
V
P
H
L
V
P
R
V
------
F
Y
S
------
D
---
T
---
E
M
----
A
V
T
V
M
E
D
L
S
H
-
L
K
I
A
R
K
G
L
I
E
GENYPH
L
S
Q
H
I
G
E
F
L
G
K
T
L
----
F
Y
S
S
D
Y
A
L
E
-
P
K
V
K
K
Q
L
-
V
K
Q
--------
F
T
-
N
P
--------------
E
L
C
D
I
T
--
E
----
R
----
L
---
V
--------
F
T
D
----
P
F
-------
F
---
D
-
H
---
D
T
N
D
F
E
EE
L
---
R
----
P
-----
F
---
V
E
----
K
----
L
-------
W
N
-----------
N
---
D
S
V
K
----
I
E
A
----
A
---
K
----
L
-------
K
K
S
F
L
TSA-
E
-
T
L
I
H
G
D
L
H
T
G
S
I
F
--------------------------
A
-
S
----
E
----
H
E
T
K
V
I
D
P
E
F
A
F
Y
G
-------------
P
I
G
F
D
V
G
Q
F
I
------
A
N
L
F
L
N
A
L
S
R
DGAD
R
E
P
L
Y
E
H
V
N
----------
Q
V
W
E
T
F
E
-
E
---------
T
F
S
E
A
W
Q
K
DSLDVYANIDG
Y
L
T
D
T
L
S
H
I
---
F
-
E
E
A
I
G
F
A
G
C
E
L
I
R
R
T
I
G
L
A
H
V
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
------
R
--
S
E
F
KT
I
T
D
V
I
E
L
F
K
L
L
V
K-----------------
26
HHSearch
63.97
15%
-4
- C- -
-
3N4U
-
?
A:
[25-280]
---------------------------
I
-----
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
-
N
R
-----------
D
-----
F
-----
I
F
K
F
-
P
K
-
H
S
R
-----
G
-----
S
T
N
L
-------
F
N
E
-
V
N
I
L
-
K
R
I
H
-
N
K
L
---
P
L
-
P
I
P
E
V
V
F
------
T
G
M
------
P
---
S
ETY
Q
M
----
S
F
A
G
F
T
K
I
K
G
-
V
P
L
T
P
L
L
L
N
-------------------------
N
L
P
K
Q
S
Q
N
-
Q
A
A
K
D
L
A
-
R
F
L
--------
S
E
-
L
H
--------------
S
I
N
I
S
G
--
F
----
K
----
S
NLV
L
--------
D
F
R
----
E
K
-------
I
---
N
-
E
---
D
N
------
K
---
K
I
K
K
L
L
-----
S
R--
E
L
----
K
----
G
-------
P
Q
-----------
M
---
K
K
V
D
----
D
F
Y
R
D
I
L
E
NEI
Y
----
F
-------
K
Y
Y
------
P
-
C
L
I
H
N
D
F
S
S
D
H
I
L
--------------------------
F
D
T
EK--
N
----
T
I
C
G
I
I
D
F
G
D
A
A
I
S
-------------
D
P
D
N
D
F
I
S
L
M
------
E
D
D
E
--
E
Y
-------------------------------
G
-
M
---------
E
F
V
S
K
I
L
N
------------
H
Y
K
H
K
D
I
P
---
T
V
L
E
K
Y
R
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
--------------------------------------------------------------------------
67
Fugue
63.89
12%
2
- C3 -
-
3CSV
11
?
A:
[4-333]
----------S
R
E
D
E
I
R
D
F
L
A
---
T
H
G
Y
-----
A
D
W
N
R
T
P
R
Y
Q
R
L
R
S
-
P
T
-----------
G
-----
A
-----
K
A
V
L
M
D
W
-
S
P
E
-----
E
-----
G
G
D
T
-------
Q
P
F
-
V
D
L
A
-
Q
Y
L
R
-
N
-
L
---
D
I
-
S
A
P
---
E
------
I
Y
A
------
E
---
E
---
H
A
----
R
G
L
L
L
I
E
D
L
G
-
D
A
L
F
T
E
V
I
N
-----------------
N
----------
D
P
A
Q
E
M
P
L
Y
R
A
A
V
-
D
L
L
--------
I
H
-
L
H
--------------
D
A
Q
T
P
E
--
L
----
A
----
R
---
L
--------
D
P
E
----
T
L
-------
S
---
E
M
T
---
R
L
------
A
---
F
----
S
-----
E
---
Y
R
----
Y
----
A
-------
I
L
GDAA
E
D
N
R
K
R
F
E
---
H
R
F
A
----
Q
I
L
----
S
---
A
----
Q
-------
L
E
G
------
D
M
V
F
V
H
R
D
F
H
A
Q
N
L
L
--------------------------
W
L
P
----
E
REGL
A
R
V
G
V
I
D
F
Q
D
A
K
L
G
-------------
H
R
A
Y
D
L
V
S
L
L
Q
DARRD
V
P
A
Q
V
E
A
Q
M
-----
I
D
H
Y
I
Q
A
T
G
VD
E
S
H
F
R
S
A
Y
A
V
I
A
V
Q
R
-
N
M
--------
R
I
L
G
I
F
A
R
------------
L
S
Q
R
F
G
K
R
---
H
-
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
H
P
A
L
A
S
A
-----------
A
E
E
I
L
N
A
L
P
A
P
A
P
E
V
------
L
--
E
R
L
R
A------------------------------
27
HHSearch
63.35
16%
-0
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[26-270]
--------------------------
S
Y
-----
K
G
I
A
E
---
N
S
N
F
L
L
-
H
T
T
K
D
--------
P
-----
L
-----
I
L
T
L
-
Y
E
-
K
-------------
K
N
D
L
-------
P
F
F
-
L
G
L
M
-
Q
H
L
A
-
A
-
K
---
G
L
-
S
C
P
L
P
L
P
------
R
K
D
GEL
L
G
E
L
---
S
---
G
R
----
P
A
A
L
I
S
F
L
E
G
-
M
W
L
R
K
P
E
------------------------------
A
K
H
-----
C
R
E
V
G
-
K
A
L
--------
A
A
-
M
H
--------------
L
A
S
E
G
F
E
I
K
R
P
--
N
ALS-
V
---
D
--------
G
W
K
----
V
L
-------
W
---
D
-
K
---
S
E
------
E
---
R
----
A
-----
D
---
E
V
----
E
----
K
G
L
R
----
E
E
-----------
I
---
R
P
E
I
----
D
Y
L
----
A
---
A
H
WP-
K
-------
D
L
P
------
A
-
G
V
I
H
A
D
L
F
Q
D
N
V
F
--------------------------
F
L
G
----
D
----
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
-------------
L
L
A
Y
D
V
S
I
C
L
------
N
A
W
C
F
E
K
-------
D
-
G
--------------------
A
Y
N
-
V
---------
T
K
G
K
A
L
L
E
------------
G
Y
Q
S
V
R
P
L
---
S
-
E
A
E
L
E
A
L
P
L
L
S
R
----------------------------------------------------------------------------------
32
HHSearch
62.67
18%
-4
- C- -
-
4H05
-
?
A:
[17-251]
--------------------------
W
V
-----
V
V
E
D
G
A
S
G
A
G
V
Y
R
L
-
R
G
GG
R
--------
E
-----
L
-----
F
V
K
V
-
A
A
-
L
G
A
-----------
G
V
G
L
-------
L
G
E
-
A
E
R
L
-
V
W
L
A
-
E
-
V
---
G
I
-
P
V
P
R
V
V
E
------
G
G
G
------
D
---
E
---
R
V
----
A
W
L
V
T
E
A
V
P
G
-
R
P
A
S
A
R
W
-----------------------------
P
R
E
Q
R
L
-
D
V
A
V
A
L
A
-
G
L
A
--------
R
S
-
L
H
--------------
A
L
D
W
E
R
--
C
----
P
----
F
---
D
RS
L
A
V
T
V
P
Q
A
A
----
R
A
-------
V
---
A
-
E
---
G
S
------
V
---
D
----
L
-----
E
---
D
L
DEER
K
----
G
-------
W
S
-----------
G
---
E
R
L
L
----
A
E
L
----
E
---
R
T
RP-
A
-------
D
E
D
------
L
-
A
V
C
H
G
D
L
C
P
D
N
V
L
--------------------------
L
D
P
----
R
TC--
E
V
T
G
L
I
D
V
G
R
V
G
R
A
-------------
D
R
H
S
D
L
A
L
V
L
------
R
E
L
A
H
E
E
D
------
P
----------------------
W
F
G
-
P
---------
E
C
S
A
A
F
L
R
------------
E
Y
G
R
G
W
D
G
---
A
-----------------------------------------------------------------------------------------------
68
Fugue
62.25
16%
38
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
---AKMRIS
P
E
L
K
K
L
I
E
K
Y
R
C
---
V
K
D
T
-----
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
-
N
E
-----------
N
-----
L
-----
Y
L
K
M
-
T
D
-
S
R
Y
-----
K
-----
G
T
T
Y
-------
D
V
E
-
R
E
K
D
-
M
M
L
W
L
E
-
G
---
K
L
-
P
V
P
K
V
L
H
------
F
E
R
------
H
---
D
---
G
W
----
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
----------------------------
Y
E
D
E
Q
S
P
E
-
K
I
I
E
L
Y
A
-
E
C
I
--------
R
L
-
F
H
S
IDISDCPYTNS
L
D
S
R
L
A
E
L
--
D
----
Y
----
L
---
L
--------
N
N
D
----
L
A
-------
D
---
V
-
D
---
C
E
------
N
---
W
----
E
-----
E
---
D
T
----
P
----
F
-------
K
D
-----------
P
---
R
E
L
Y
----
D
F
L
----
K
---
T
E
K--
P
-------
E
E
E
------
L
-
V
F
S
H
G
D
L
G
D
S
N
I
F
--------------------------
V
K
D
----
G
----
K
V
S
G
F
I
D
L
G
R
S
G
R
A
-------------
D
K
W
Y
D
I
A
F
C
V
------
R
S
I
R
E
D
I
G
------
E
---
E
Q
Y
V
E
----------
L
F
F
D
L
L
G
-
I
---------
K
P
D
W
E
K
I
K
------------
Y
Y
I
L
L
D
E
L
---
F
-----------------------------------------------------------------------------------------------
43
HHSearch
61.34
15%
-2
- C3 -
-
4DCA
1
?
A:
[42-276]
---------------------------
L
-----
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
-
N
E
-----------
Q
-----
Y
-----
V
V
K
V
-
P
K
-
R
D
S
-----
V
-----
R
I
S
Q
-------
K
R
E
-
L
E
L
Y
-
R
F
L
E
-
N
-
C
KL-
S
Y
-
Q
I
P
A
V
V
Y
------
Q
----------------
S
D
----
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
H
-------------------------
K
L
S
E
K
E
K
D
-
A
L
A
Y
D
E
A
-
T
F
L
--------
K
E
-
L
H
--------------
S
I
E
I
D
C
--
S
----
V
S
---
L
F
--
S
D
A
LVN---
K
K
D
----
K
F
-------
L
Q
D
K
K
-
L
L
I
S
I
L
------
E
---
K
----
E
-----
Q
---
L
L
----
T
----
D
-------
E
M
-----------
L
E
H
I
E
T
I
Y
----
E
N
I
----
L
---
S
NAVL
F
-------
K
Y
T
------
P
-
C
L
V
H
N
D
F
S
A
N
N
M
I
--------------------------
F
R
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
-------------
D
P
D
N
D
F
L
C
L
L
------
D
C
S
T
-
D
D
-------------------------------
F
G
-
K
---------
E
F
G
R
K
V
L
K
------------
Y
Y
Q
H
K
A
P
E
---
V
-
A
E
--------------------------------------------------------------------------------------------
44
HHSearch
61.27
15%
-19
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[25-247]
---------------------------
A
-----
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
-
S
A
-----------
Q
G
R
P
V
-
L
-----
F
V
K
T
-
D
L
-
S
G
A
-----------
L
N
E
L
-------
Q
D
E
-
A
A
R
L
-
S
W
L
A
-
T
-
T
---
G
V
-
P
C
A
A
V
L
D
------
V
V
T
------
E
---
A
---
G
R
----
D
W
L
L
L
G
E
V
P
G
-
Q
D
L
L
S
S
H
---------------------------
L
A
P
A
-----
E
K
V
S
I
M
A
-
D
A
M
--------
R
R
-
L
H
--------------
T
L
D
P
A
T
--
C
----
P
----
F
---
D
HQ
A
K
H
R
I
E
R
A
R
----
T
R
-------
M
---
E
-
A
---
G
L
------
V
---
D
----
Q
-----
D
---
D
L
----
D
EEHQ
G
-------
L
A
-----------
P
---
A
E
L
F
----
A
R
L
----
K
---
A
R
MP-
D
-------
G
E
D
------
L
-
V
V
T
H
G
D
A
C
L
P
N
I
M
--------------------------
V
E
N
----
G
----
R
F
S
G
F
I
D
C
G
R
L
G
V
A
-------------
D
R
Y
Q
D
I
A
L
A
T
------
R
D
I
A
E
-
E
L
-------------------------------
G
-
G
---------
E
W
A
D
R
F
L
V
------------
L
Y
G
I
A
------------------------------------------------------------------------------------------------------
64
Fugue
59.93
14%
32
- C3 -
-
3HAM
3
?
A:
[1-299]
----MVNLD
A
E
I
Y
E
H
L
N
K
Q
I
K
---
I
N
E
L
-----
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
-
N
E
-----------
Q
-----
Y
-----
V
V
K
V
-
P
K
-
R
D
S
-----
V
-----
R
I
S
Q
-------
K
R
E
-
F
E
L
Y
-
R
F
L
E
-
N
-
C
---
K
L
-
S
Y
Q
I
P
A
V
------
V
Y
Q
--------------
S
D
----
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
H
-----------------
K
L
S
----
E
K
E
K
D
A
L
A
Y
-
D
E
A
T
F
L
K
-
E
L
H
S
IEIDCSV
S
L
-
F
S
--------------
D
A
L
V
N
K
--
K
----
D
----
K
---
F
--------
L
Q
D
----
K
K
-------
L
---
L
-
I
---
S
I
------
L
---
E
----
K
E
----
Q
---
L
L
----
T
----
D
-------
E
M
-----------
L
---
E
H
I
E
----
T
I
Y
----
E
---
N
----
I
L
N
NAVLF
K
Y
T
------
P
-
C
L
V
H
N
D
F
S
A
N
N
M
I
--------------------------
F
R
N
----
N
----
R
L
F
G
V
I
D
F
G
D
F
N
V
G
-------------
D
P
D
N
D
F
L
---------------
C
L
------
L
D
C
S
T
D
D
F
G
----------
K
E
F
G
R
K
V
-
L
---------
K
Y
Y
Q
H
K
A
P
------------
E
V
A
E
R
K
A
E
---
L
-
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
----------
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
---------------------------------------------
63
Fugue
59.35
14%
0
- C3 -
-
3UQC
-
MVINL_MYCTU
A:
[20-265]
--------VQLVPGARIAN
G
R
---
Y
R
L
L
-----
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
-
L
D
-----------
T
-----
A
LD
R
Q
V
A
L
T
F
-
V
D
P
Q
G
V
-----
L
-----
P
D
D
V
-------
L
Q
E
-
T
L
S
R
-
T
L
R
L
-
S
-
R
ID-
K
P
-
G
V
A
R
V
L
D
------
V
V
H
------
T
---
R
---
A
G
----
G
L
V
V
A
E
W
I
R
G
-
G
S
L
Q
E
V
A
----------------------------
D
T
S
P
S
P
V
-
G
A
I
R
A
M
Q
-
S
L
A
--------
A
A
-
A
D
--------------
A
A
H
R
A
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
L
S
I
D
H
P
S
R
V
R
--------------------------
V
S
I
----
D
----
G
D
V
V
L
A
Y
P
A
T
M
P
D
A
-------------
N
P
Q
D
D
I
R
G
I
G
------
A
S
L
-
Y
A
L
L
------
V
N
R
W
P
L
P
E
A
----------
G
V
R
S
G
L
A
-
P
---------------
A
E
------------
R
D
T
A
G
Q
P
I
---
E
-
P
A
D
I
D
R
-
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
----------
G
G
I
R
S
A
S
T
L
L
N
L
M
Q
Q
A
------
T
--
A
----------------------------------
49
HHSearch
58.61
14%
3
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[35-275]
-------------------------------------
N
S
Y
E
N
R
V
Y
Q
F
-
Q
D
EDR
R
-------
R
-----
F
-----
V
V
K
F
-
Y
R
-
P
E
R
W----
T
-----
A
D
Q
I
-------
L
E
E
-
H
Q
F
A
-
L
Q
L
V
-
N
-
D
---
E
V
-
P
V
A
A
P
V
A
------
F
N
G
QT
L
L
N
-
H
---
Q
---
G
F
----
Y
F
A
V
F
P
S
V
G
G
-
R
Q
F
E
A
D
N
------------------------------
I
-----
D
Q
M
E
A
V
G
-
R
Y
L
--------
G
R
-
M
H
--------------
Q
T
G
R
K
Q
--
L
FIHR
P
----
T
---
I
--------
G
L
N
----
E
Y
-------
L
I
E
P
R
-
K
---
L
F
------
E
---
D
----
A
-----
T
---
L
I
----
P
----
S
GL
K
A
A
F
L
K
A
-----------
T
---
D
E
L
I
----
A
A
V
----
T
---
A
H
WR-
E
-------
D
F
T
------
V
-
L
R
L
H
G
D
C
H
A
G
N
I
L
--------------------------
W
R
D
---------
G
-
P
M
F
V
D
L
D
D
A
R
N
G
-------------
P
A
V
Q
D
L
W
M
L
L
------
N
G
D
K
--
A
E
-------------------------------
Q
-
R
---------
M
Q
L
E
T
I
I
E
------------
A
Y
E
E
F
S
E
F
---
D
-
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
------------------------------------------------------------------------------
34
HHSearch
58.52
18%
-6
- C3 -
-
3TDW
1
?
A:
[24-236]
---------------------------
V
-----
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
-
N
G
-----------
D
-----
W
-----
V
F
R
F
-
P
K
-
S
Q
Q
-----
G
-----
A
D
E
L
-------
N
K
E
-
I
Q
L
L
-
P
L
L
V
-
G
-
C
V--
K
V
-
N
I
P
Q
Y
V
Y
------
I
G
K
R
-----
S
---
D
---
G
N
----
P
F
V
G
Y
R
K
V
Q
G
-
Q
I
L
G
E
D
G
M
A
-------------------------
V
L
P
D
D
A
K
D
-
R
L
A
L
Q
L
A
-
E
F
M
--------
N
E
-
L
S
--------------
A
F
P
V
E
T
--
A
I
---
S
----
A
---
G
V
P
V
T
----
N
L
K
----
N
K
-------
I
---
L
-
L
---
L
S
------
E
---
A
----
V
E
D
QVF
P
---
L
L
----
D
----
E
-------
S
L
-----------
R
---
D
Y
L
T
L
R
F
Q
S
Y
M
----
T
HPV
Y
----
T
-------
R
Y
T
------
P
-
R
L
I
H
G
D
L
S
P
D
H
F
L
--------------------------
T
N
L
NSRQ
T
----
P
L
T
G
I
I
D
F
G
D
A
A
I
S
-------------
D
P
D
Y
D
Y
V
Y
L
L
------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
SP3
56.45
16%
-5
- C3 -
-
1O6Y
1
PKNB_MYCTU
A:
[23-298]
----------------TPS
H
L
SD
R
Y
E
L
G
-----
E
I
L
G
F
G
G
M
S
E
V
H
L
A
-
R
D
-----------
L
RLH
R
D
V
-----
A
V
K
V
-
L
R
-
A
D
L
-----
A
R
D
P
S
F
Y
L
R
F
-------
R
R
E
-
A
Q
N
A
-
A
A
L
N
-
H
------
P
-
A
I
V
A
V
Y
D
------
T
G
E
------
A
---
E
---
T
P
A
G
P
L
P
Y
I
V
M
E
Y
V
D
G
-
V
T
L
R
D
I
V
H
T
-----------------
E
G
P
----
M
T
--
P
K
R
A
I
-
E
V
I
A
D
A
C
-
Q
A
L
--------
N
F
-
S
H
--------------
Q
N
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
V
K
P
A
N
I
M
--------------------------
I
S
A
----
T
----
N
A
V
K
V
M
D
F
G
I
A
R
------------------------------------
A
I
A
------
Q
Y
L
S
P
E
Q
A
R
----------
G
D
S
V
D
A
R
-
S
---------
D
V
Y
S
L
G
C
V
------------
L
Y
E
V
L
T
G
E
PPF
T
-
G
D
S
P
V
S
V
A
Y
Q
H
V
R
E
D
P
I
P
P
S
A
R
H
E
----------
G
L
S
A
D
L
D
A
V
V
L
K
A
L
A
K
------
N
PE
N
R
Y
QT
A
A
E
M
R
A
D
L
V
R
V
H
N-----------------
29
HHSearch
54.53
17%
-1
- C3 -
-
5IQI
1
AACA_STAAU
C:
[31-237]
---------------------------
I
-----
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
-
N
N
-----------
E
-----
Y
-----
I
F
K
T
-
K
F
-
S
T
N
-----
K
-----
K
K
G
F
-------
A
K
E
-
K
A
I
Y
-
N
F
L
N
-
T
-
N
LET
N
V
-
K
I
P
N
I
E
Y
------
S
Y
I
------
S
---
D
---
E
L
----
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
E
I
Y
S
-------------------------
T
M
S
E
E
E
Q
N
-
L
L
K
R
D
I
A
-
S
F
L
--------
R
Q
-
M
H
--------------
G
L
D
Y
T
D
--
I
----
S
ECT-
I
---
D
--------
N
K
Q
----
N
V
-------
L
---
E
-
E
---
Y
I
------
L
L
R
E
T
I---
Y
-----
N
---
D
L
----
T
D
I
E
-
K
-------
D
Y
-----------
I
---
E
S
F
M
----
E
R
L
----
N
---
A
TTV-
F
-------
E
G
K
------
K
-
C
L
C
H
N
D
F
S
C
N
H
L
L
--------------------------
L
D
G
----
N
N---
R
L
T
G
I
I
D
F
G
D
S
G
I
I
-------------
D
E
Y
C
D
F
I
Y
L
L
------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
49.11
16%
8
- C3 -
-
5IQC
2
AACA_STAAU
A:
[31-237]
---------------------------
I
-----
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
-
N
N
-----------
E
-----
Y
-----
I
F
K
T
-
K
F
-
S
T
N
-----
K
-----
K
K
G
Y
-------
A
K
E
-
K
A
I
Y
-
N
F
L
N
-
T
-
N
LET
N
V
-
K
I
P
N
I
E
Y
------
S
Y
I
------
S
---
D
---
E
L
----
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
E
I
Y
S
-------------------------
T
M
S
E
E
E
Q
N
-
L
L
K
R
D
I
A
-
S
F
L
--------
R
Q
-
M
H
--------------
G
L
D
Y
T
D
--
I
----
S
ECT-
I
---
D
--------
N
K
Q
----
N
V
-------
L
---
E
-
E
Y
I
L
L
R
------
E
---
T
----
I
Y----
N
---
D
L
----
T
----
D
I
E
K
----
D
Y
-----------
I
---
E
S
F
M
----
E
R
L
----
N
---
A
TTV-
F
-------
E
G
K
------
K
-
C
L
C
H
N
D
F
S
C
N
H
L
L
--------------------------
L
D
G
----
N
N---
R
L
T
G
I
I
D
F
G
D
S
G
I
I
-------------
D
E
Y
C
D
F
I
Y
L
L
------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------