@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : F8FI03_PAEMK: (2019-01-28 )
METKLGRKIGEGGCSEVYEYGTEQPVKIIKLAKSNTSMDAMRIEYRNHRTTWELGLPVPQPFDLRVVDGRPGIVVEQIQGETLMQRFLRGLDQPEVSEDSPIYDDVRMTARILNALHSHSAEALPSQRESIKGALLGVESLTAPEKKEICAILDDLPVKQRLCHGDPNPGNIFVRHDEGLLIDWMNASAGNPEADLAEYILMVRYAVLPSHLGARIIGRFHSIREMMIDAFMEEYTRLSGVTAEEVDPWMLPMAARKLSADAISDEEKGLLLHEIRVRLNAYKGAEESFRE
Atome Classification :
(20 SA)
------------------------------------------.......----..10...--------.-....20---------..--.-.....30--......---.-.-------.40........50.-----.-.--------...---..60.----.------.-------..------.----------..70....--....80------.------------..--------......90-------------------------.----------..-......100.......110......-----------.------120------.------.-----.----------.--..---------.130------...------.----.---------.---.140--..----.-------------------.-----....---.------150...----.-------..---------.160.--.----------.......170.....----.-.180-.......190-----------------------------------------........200......--.210.......220-----.........230-------...--.-.-----------..240---.........250.......260-----.---.......270--.--..-------......280.......290------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------METKLGR----KIGEG
G
C
--------
S
-
E
V
Y
E
YG---------TE--Q-P
V
K
I
I
K
---
L
AKSNT---S-M-------
D
A
M
R
I
E
YRNHR
T
T
W
-----E-L--------GLP---VPQPF----
D
------
L
-------
R
V
------V----------DGRP
G
I
V
V
--
E
QIQ
G
-------
E
------------
T
L
--------
M
Q
R
F
L
R
G--------------------------L----------DQ-PEVSEDSP
I
Y
D
D
V
R
M
T
A
R
I
L
N
A
L
H
S-----------H------
S
A
E
------A------L-----P----------
S
--
Q
R
---------
E
S
I
K
------
G
A
L------L----G---------V---ES----LT----A-------------------P-----
E
K
K
E
---
I
------
C
A
I
L
DD----L-------
P
V
---------
K
Q
--
R
--L----------CHGDPNP
G
N
I
F
V
RHD----E-
G
L
L
I
-
D
W
MNASAGN------------------------------------------P
E
A
D
L
A
E
Y
I
L
M
V
R
Y
A
V
L
--
P
S
H
L
G
A
R
I
I
G
R
F
-------
H
S
I
R
E
M
M
I
D
A
F
M
-------
E
E
Y
--
T
-
R
-----------LSG-----V
T
A
E
EVDP
W
M
L
P
M
A
A
R
KLSAD------A---ISDEEK
G
L
----
L
--
L
H
-------
E
I
R
V
R
L
NAYKG
A
E
E
S
FRE-------------------------
31
Fugue
75.13
25%
38
- C3 -
-
4WW7
1
BUD32_YEAST
A:
[4-257]
-----------------------------------------E
F
I
D
K
V
S
S
----
Y
L
T
P
D
V
D
--------
I
-
A
P
I
S
Q
G
---------
A
A
--
I
-
V
F
T
T
T
T
HPY
L
P
R
A
K
D
---
S
-
H
-------
Q
K
Y
I
I
K
Y
R
P
R
T
L
N
E
S
R
L
L
A
K
-
L
Y
L
IP----
G
L
C
---
V
P
Q
-------------
L
-------
I
A
------
C
----------
D
P
Y
N
G
F
I
W
--
L
E
F
L
G
-------
E
------------
D
L
PGGHGFSN
L
K
N
F
L
W
M
--------------------------
H
----------
D
Q
-
D
--
P
Y
S
D
L
V
A
T
T
L
R
K
V
G
R
Q
I
G
L
L
H
W
-----------
N
------
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
----------
C
H
G
D
L
T
S
S
N
I
V
L
V
R
D
GA
R
W
T
-
P
H
L
I
-
D
F
G
L
G
S
V
S
N
------------------------------------------
L
V
E
D
K
G
V
D
L
Y
V
L
E
R
A
I
L
--
S
T
H
------------------------
S
K
H
A
-------
E
K
Y
--
N
-
A
-----------
W
I
M
-----
E
G
F
E
E
V
Y
R
E
Q
G
A
K
G
A
K
K
L
K
E
V
------
T
---
K
R
F
E
E
V
R
L
----
R
--
G
R
-------
K
R
-----------------------------------------
48
HHSearch
71.21
19%
-38
- C3 -
-
4H05
-
?
B:
[15-251]
--------------------------------------------
C
E
W
V
V
----
V
E
D
G
A
S
G
--------
A
-
G
V
Y
R
L
R
---------
G
G
--
G
-
R
E
L
F
V
K
---
V
A
A
L
G
A
-----
G
-------
V
G
L
L
G
E
A
E
R
L
V
W
L
A
-----
E
-
V
--------
G
I
P
---
V
P
R
V
V
----
E
------
G
-------
G
G
------
D
----------
E
R
V
A
W
L
V
T
--
E
A
V
P
G
-------
R
------------
P
A
--------
S
A
R
W
-----------------------------------------------
P
R
E
Q
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
-----------
L
------
D
W
E
------
R
------
C
-----
P
FDRS
L
A
V
T
V
P
Q
--
A
A
---------
R
A
V
A
------
E
G
S
------
V
----
D
---------
L
---
E
D
LDEE
R
K
----
G
-------------------
W
-----
S
G
E
R
---
L
------
L
A
E
L
E
R
T
RP-
A
-------
D
E
---------
D
L
--
A
--
V
----------
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
TC--
E
V
T
G
L
I
-
D
V
G
R
V
G
R
A
D
------------------------------------------
R
H
S
D
L
A
L
V
L
R
E
L
A
H
E
E
D
---
P
------------------
W
F
G
P
E
C
S
A
A
F
L
-------
R
E
Y
--
G
-
R
-----------
G
W
D
-----
G
A
------------------------------------------------------------------------------------------------
49
HHSearch
67.98
19%
-33
- C- -
-
4H05
-
?
A:
[15-251]
--------------------------------------------
C
E
W
V
V
----
V
E
D
G
A
S
G
--------
A
-
G
V
Y
R
L
R
---------
G
G
--
G
-
R
E
L
F
V
K
---
V
A
A
L
G
A
-----
G
-------
V
G
L
L
G
E
A
E
R
L
V
W
L
A
-----
E
-
V
--------
G
I
P
---
V
P
R
V
V
----
E
------
G
-------
G
G
------
D
----------
E
R
V
A
W
L
V
T
--
E
A
V
P
G
-------
R
------------
P
A
--------
S
A
R
W
-----------------------------------------------
P
R
E
Q
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
-----------
L
------
D
W
E
------
R
------
C
-----
P
FDRS
L
A
V
T
V
P
Q
--
A
A
---------
R
A
V
A
------
E
G
S
------
V
----
D
---------
L
---
E
D
LDEE
R
K
----
G
-------------------
W
-----
S
G
E
R
---
L
------
L
A
E
L
E
R
T
RP-
A
-------
D
E
---------
D
L
--
A
--
V
----------
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
TC--
E
V
T
G
L
I
-
D
V
G
R
V
G
R
A
D
------------------------------------------
R
H
S
D
L
A
L
V
L
R
E
L
A
H
E
E
D
---
P
------------------
W
F
G
P
E
C
S
A
A
F
L
-------
R
E
Y
--
G
-
R
-----------
G
W
D
-----
G
A
------------------------------------------------------------------------------------------------
56
HHSearch
66.15
19%
-10
- C3 -
-
5UXD
2
?
A:
[26-255]
-----------------------------------------------
L
R
----
T
E
E
I
G
L
D
--------
F
-
R
V
A
F
A
R
---------
A
H
--
D
G
G
D
W
V
L
R
---
L
P
R
R
P
D
---
V
-
L
-------
E
R
A
A
V
E
G
R
L
L
A
M
L
A
-----
P
H
L
--------
D
V
A
---
V
P
D
W
R
----
I
------
S
-------
T
--------------------
S
E
L
I
A
Y
--
P
L
L
P
G
-------
S
------------
P
G
--------
L
T
V
A
A
D
G
--------------------------
E
-----------
V
-
S
-
W
H
V
D
M
A
S
T
V
Y
A
R
S
L
G
S
V
V
A
Q
L
H
A
-----------
V
------
D
A
E
------
A
------
A
-----
A
A
T
G
I
E
V
R
S
P
A
Q
--
V
R
---------
G
A
W
R
------
Q
D
L
------
A
----
R
---------
V
---
G
A
E
F
E-
I
A
----
P
-------------------
A
-----
L
R
E
R
---
W
------
E
A
W
L
A
D
----
D
GCW----
P
G
---------
H
S
--
V
--
L
----------
T
H
G
E
L
Y
P
A
H
T
L
V
E
D
E
----
R
I
T
A
V
L
-
D
W
T
T
A
A
V
G
D
------------------------------------------
P
A
K
D
L
M
F
H
Q
V
S
A
-------
P
----------------------
S
A
I
F
E
V
A
L
-------
Q
A
Y
--
A
-
E
-----------
G
G
G
-----
R
P
------------------------------------------------------------------------------------------------
50
HHSearch
64.66
16%
-42
- C3 -
-
3DXP
1
?
A:
[43-301]
-----------------------------------------------
V
E
----
Q
F
K
G
-
Q
S
--------
N
-
P
T
F
K
L
V
---------
T
P
--
G
-
Q
T
Y
V
M
R
---
A
K
P
G
----------------
A
I
E
R
E
Y
R
V
M
D
A
L
A
-----
G
-
T
--------
D
V
P
---
V
A
K
M
Y
----
A
------
L
-------
C
E
------
D
ESV-------
I
G
R
A
F
Y
I
M
--
E
F
V
S
G
-------
R
------------
V
L
--------
W
D
Q
S
L
P
-------------------------------------------
G
M
S
P
A
E
R
T
A
I
Y
D
E
M
N
R
V
I
A
A
M
H
T
-----------
V
------
D
Y
Q
------
A
------
I
GLGDY
G
----------
K
--
P
G
---------
N
Y
F
Q
------
R
Q
I
------
E
R
W
T
K
Q
---------
Y
K
L
S
E
T
----
E
S
----
I
-------------------
P
-----
A
M
D
S
---
L
------
M
D
W
L
P
Q
H
IPQ
E
D------
A
D
---------
L
T
--
S
--
I
----------
V
H
G
D
Y
R
L
D
N
L
M
F
H
P
T
EP--
R
V
L
A
V
L
-
D
W
E
L
S
T
L
G
H
------------------------------------------
P
M
G
D
F
G
Y
H
C
M
S
W
---
H
I
--
A
P
G
Q
F
---
R
G
----------
I
A
G
L
D
H
A
A
L
G
I
PD
E
A
S
Y
R
K
L
Y
--
E
-
Q
-----------
R
T
G
-----
R
P
I
T
----------------------------------------------------------------------------------------------
38
SP3
61.60
13%
31
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------------------AKMRIS
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
--------
P
A
K
V
Y
K
L
V
---------
G
E
--
N
-
E
N
L
Y
L
K
---
M
T
D
S
R
Y
KG-
T
-
T
-------
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
-----
G
----------
K
L
P
---
V
P
K
V
L
----
H
------
F
-------
E
R
------
H
----------
D
G
W
S
N
L
L
M
--
S
E
A
D
G
-------
V
------------
L
C
--------
S
E
E
Y
E
D
E
--------------------------
Q
----------
S
P
----------
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
-----------
I
------
D
I
S
------
D
CPYTNS
L
-----
D
----------
S
--
R
L
---------
A
E
L
D
------
Y
L
L
N
N
DLAD
V
----
D
---------
C
---
E
N
----
W
E
----
E
-------------------
D
TPFKD
P
R
E
L
---
Y
------
D
F
L
K
T
E
----
K
-------
P
E
---------
E
E
L
-
V
--
F
----------
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
----
K
V
S
G
F
I
-
D
L
G
R
S
G
R
A
D
------------------------------------------
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
D
I
G
--
E
E
--------------------------
Q
Y
V
-------
E
L
F
--
F
-
D
-----------
L
L
G
-----
I
K
P
D
W
-
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------------------------------------------------------
59
HHSearch
60.99
13%
-13
- C3 -
-
6EF6
2
?
A:
[47-308]
------------------------------------------------
R
----
L
L
-
N
L
S
E
--------
N
-
A
T
Y
L
V
E
---------
D
G
--
E
-
H
Q
S
I
L
R
---
V
H
R
Q
D
Y
---
H
Q
P
-------
H
E
I
E
S
E
L
D
W
L
A
A
L
R
-----
T
D
S
--------
D
V
T
---
V
P
T
V
V
----
P
------
A
-------
R
D
------
G
RR
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
--
E
M
V
G
G
-------
A
------------
E
P
--------
D
E
E
S
----------------------------------------------
L
T
L
D
D
F
Q
T
L
G
R
I
T
A
S
L
H
E
H
S
Q
R
-----------
W
------
T
R
P
------
A
G-----
F
-----
G
R
F
--------
S
WD
W
E
---------
H
C
L
G
DTPRWG
R
W
Q
------
D
----
A
---------
E
GV-
G
A
----
S
E
T
A
L
L
T
-------------------
R
-----
A
Q
D
L
---
L
------
H
R
K
L
E
E
----
Y
GSG----
P
D
---------
R
Y
--
G
--
L
----------
I
H
A
D
L
R
L
A
N
L
L
V
D
S
S
TPQ-
R
T
I
T
V
I
-
D
F
D
D
C
G
F
G
W
------------------------------------------
Y
F
Y
D
F
G
T
A
V
S
F
I
E
H
D
P
------------------------
R
L
G
E
W
Q
E
S
W
V
-------
A
G
Y
--
R
-
S
-----------
R
R
E
-----
L
P
A
A
D
E
A
M
L
P
S
F
V
F
------------------------------------------------------------------------------------
23
Fugue
60.95
13%
7
- C3 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
----------------T
L
P
A
V
I
S
R
W
L
S
S
V
LPGGAA
P
E
V
T
V
ES
G
V
D
S
T
G
M
----
S
S
E
T
I
I
L
--------
T
-
A
R
W
Q
Q
D
---------
G
R
--
S
-
I
Q
Q
K
L
V
---
A
R
V
A
P
A
---
A
-
E
DVPVFPT
Y
R
L
D
H
Q
F
E
V
I
R
L
V
G
-----
E
-
L
T-------
D
V
P
---
V
P
R
V
R
----
W
------
I
ETT----
G
D
------
V
----------
L
G
T
P
F
F
L
M
--
D
Y
V
E
G
-------
V
------------
V
P
PD------
V
M
P
Y
T
F
G
DNW-----------------------
F
----------
A
D
-
A
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
-----------
A
------
Q
N
T
------
F
------
S
-----
F
----------
L
--
T
D
---------
T
T
L
H
------
R
H
F
------
N
----
W
---------
V
---
R
S
----
W
Y
----
D
-------------------
F
-----
A
V
E
G
---
I
G
R
S
P
L
L
E
R
T
F
E
W
----
L
-------
Q
S
H
WP
D
D
A
A
A
R
E
P
--
V
--
L
----------
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
F
----
Q
-
P
V
A
V
L
D
W
E
M
V
A
L
G
P
------------------------------------------
R
E
L
D
V
A
W
M
I
F
A
H
R
V
F
Q
E
--
L
A
G
L
A
----
T
L
P
-------
G
L
P
E
V
M
R
E
D
D
V
R
-------
A
T
Y
--
Q
-
A
-----------
L
T
G
-----
V
E
L
G
D
L
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
F
------
M
---
R
T
G
A
R
R
V
H
----
F
--
G
E
IEKPDDV
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
-------------------------
21
Fugue
60.83
15%
13
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
----------------------KTPL
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
K
L
G
L
T
L
T
C
Q
----
E
I
G
D
G
N
L
--------
N
-
Y
V
F
H
I
Y
---------
D
R
--
A
-
L
I
I
K
Q
A
---
V
P
Y
W
P
L
---
T
-
I
-------
D
R
A
R
I
E
S
S
A
L
I
R
Q
G
-----
E
-
H
---------
V
P
---
H
L
V
P
R
----
V
------
F
-------
Y
S
------
D
----------
T
E
M
A
V
T
V
M
--
E
D
L
S
H
-------
L
------------
K
I
--------
A
R
K
G
L
I
E
GENYPH
L
S
Q
H
I
G
E
F
L
G
K
T
L
F
Y
S
SDYA
L
----------
E
P
-
K
V
K
K
Q
L
V
K
Q
F
T
N
P
E
L
C
D
I
T
E
R
L
V
F
T
-----------
D
------
P
F
F
------
D
------
H
-----
D
----------
T
--
N
D
---------
F
E
E
E
------
L
R
P
------
F
----
V
---------
E
---
K
L
----
W
N
----
N
-------------------
D
-----
S
V
K
I
---
E
------
A
A
K
L
K
K
----
S
-------
F
L
---------
T
S
--
A
ET
L
----------
I
H
G
D
L
H
T
G
S
I
F
A
S
E
H
----
E
-
T
K
V
I
-
D
P
E
F
A
F
Y
G
P
------------------------------------------
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
N
A
L
S
R
D
G
A
D
R
E
P
L
Y
E
H
V
-------
N
Q
V
W
E
T
F
E
E
T
F
S
-------
E
A
W
--
Q
-
K
DSLDVYANIDG
Y
L
T
-----
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
------
T
---
I
G
L
A
H
V
A
D
----
L
D
T
I
V
-------
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K--
24
Fugue
59.45
14%
58
- C3 -
-
3HAM
3
?
A:
[1-299]
---------------------------MVNLD
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
L
R
----
Y
L
S
S
G
D
D
--------
S
-
D
T
F
L
C
N
---------
E
Q
------
Y
V
V
K
---
V
P
K
R
D
S
---
V
-
R
-------
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
-----
N
-
C
--------
K
L
S
---
Y
Q
I
P
------------
A
-------
V
V
------
Y
----------
Q
S
D
R
F
N
I
M
--
K
Y
I
K
G
-------
E
------------
R
I
--------
T
Y
E
Q
Y
H
K
--------------------------
L
----------
S
----
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
DCSVSLFSDAL
V
------
N
K
K
------
D
------
K
-----
F
----------
L
--
Q
D
---------
K
K
L
L
------
I
S
I
------
L
----
E
---------
K
---
E
Q
L---
L
T
----
D
-------------------
E
-----
M
L
E
H
---
I
------
E
T
I
Y
E
N
----
I
L
N
NAVLF
K
Y
---------
T
P
--
C
--
L
----------
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
----
R
L
F
G
V
I
-
D
F
G
D
F
N
V
G
D
------------------------------------------
P
D
N
D
F
L
C
L
L
D
C
S
T
-------------------------
D
D
F
G
K
E
F
G
R
K
V
L
-------
K
Y
Y
--
Q
H
K
-----------
A
P
E
-----
V
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
------
Y
---
E
R
K
D
R
E
M
L
----
I
--
K
G
-------
V
S
E
L
L
----
Q
T
Q
A
E
M
F
I
F
-------------------------
28
Fugue
58.96
15%
9
- C3 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
---------------------SAFT
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
V
D
S
G
L
----
T
P
L
N
S
Y
E
--------
N
-
R
V
Y
Q
F
Q
---------
D
E
--
D
R
R
R
F
V
V
K
---
F
Y
R
P
E
R
W--
T
-
A
-------
D
Q
I
L
E
E
H
Q
F
A
L
Q
L
V
-----
N
-
D
--------
E
V
P
---
V
A
A
P
V
----
A
F
NGQT-
L
-------
L
N
------
H
----------
Q
G
F
Y
F
A
V
F
--
P
S
V
G
G
-------
R
------------
Q
F
------------------------------------------------------------
E
A
D
N
I
D
Q
M
E
A
V
G
R
Y
L
G
R
M
H
Q
-----------
T
------
G
R
K
------
Q
------
L
-----
F
----------
I
--
H
R
PTIGLNEYL
I
E
P
R
------
K
L
F
------
E
----
D
---------
A
---
T
L
----
I
P
----
S
-------------------
G
-----
L
K
A
A
---
F
------
L
K
A
T
D
E
----
L
-------
I
A
---------
A
V
--
T
--
A
H
WRED
F
T
V
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
G
----
P
-
M
F
-
V
-
D
L
D
D
A
R
N
G
P
------------------------------------------
A
V
Q
D
L
W
--
M
L
L
N
G
D
K
A
E
--
Q
R
M
Q
L
E
T
I
I
E
A
Y
E
E
FSEFD
T
A
E
I
G
L
I
E
P
L
R
A
-------
M
R
L
--
V
-
Y
-----------
Y
L
A
-----
W
L
M
R
R
W
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
------
D
---
Y
W
L
R
Q
T
A
T
----
F
--
I
E
-------
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
P
M
Y
---------------------------
29
Fugue
58.92
15%
31
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
---------------------------------------TDI
T
E
D
E
L
R
N
----
F
L
T
Q
Y
D
V
--------
G
-
S
L
T
S
Y
K
---------
G
I
--
A
-
E
N
S
N
F
L
---
L
H
T
T
K
D
---
P
-
L
-------
I
L
T
L
Y
E
K
K
N
D
L
P
F
F
-----
L
-
G
L
M
Q
H
L
A
A
K
G
L
S
---
C
P
L
P
L
----
P
R
KDGEL
L
-------
G
E
------
L
----------
S
G
R
P
A
A
L
I
--
S
F
L
E
G
M
W
L
RKPE
A
------------
K
H
--------
C
R
E
V
G
K
A
--------------------------
L
----------
A
A
M
H
L
A
S
E
G
F
E
I
K
R
P
N
A
L
S
V
D
G
W
K
V
L
W
D
-----------
K
------
S
E
E
------
R
------
A
-----
D
----------
E
--
V
E
---------
K
G
L
R
------
E
E
I
------
R
----
P
---------
E
---
I
D
----
Y
L
----
A
-------------------
A
-----
H
W
P
K
----------------------------
D
L
---------
P
A
--
G
--
V
----------
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
-
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
------------------------------------------
L
A
Y
D
V
S
--
I
C
L
N
A
W
C
F
E
--
K
D
G
-----------------
A
Y
N
V
T
K
G
K
A
L
L
-------
E
G
Y
--
Q
-
S
-----------
V
R
P
-----
L
S
E
A
E
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
------
L
---
T
R
L
Y
D
W
L
T
----
T
--
P
A
-------
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
IANVAEYGLA------------
32
Fugue
58.52
12%
-19
- C3 -
-
3UQC
-
MVINL_MYCTU
A:
[20-265]
-------------------------------VQLVPGARIAN
G
R
Y
R
L
L
I
----
F
H
G
G
V
P
P
--------
L
-
Q
F
W
Q
A
L
DTALD----
R
Q
--
V
-
A
L
T
F
V
D
---
P
Q
G
V
L
P
---
D
-
D
-------
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
-----
I
-
D
--------
K
P
G
---
V
A
R
V
L
----
D
------
V
-------
V
H
------
T
----------
R
A
G
G
L
V
V
A
--
E
W
I
R
G
-------
G
------------
S
L
--------
Q
E
V
A
D
T
S
--------------------------
P
----------
S
-------
P
V
G
A
I
R
A
M
Q
S
L
A
A
A
A
D
A
A
H
R
-----------
A
------
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
----
G
-
D
V
V
L
A
Y
P
A
T
M
P
D
A
N
------------------------------------------
P
Q
D
D
I
R
G
I
G
A
S
L
-
Y
A
L
L
--
V
N
R
W
P
L
P
E
A
G
V
R
-------
S
G
L
A
P
A
-------------
E
R
D
--
T
-
A
-----------
G
Q
P
-----
I
E
P
A
D
I
D
R
-
D
I
P
F
Q
I
S
A
V
A
A
R
------
S
---
V
Q
G
D
G
G
I
R
----
S
--
A
S
-------
T
L
L
N
L
M
Q
Q
A
T
A
--------------------------------
43
SP3
58.38
13%
-15
- C3 -
-
1B6C
-
TGFR1_HUMAN
B:
[14-339]
--------------TT
L
K
D
L
I
Y
D
M
TTSGSGSGLP
L
L
V
Q
R
T
I
A
R
T
I
V
L
Q
E
----
S
I
G
K
G
R
F
--------
G
-
E
V
W
R
G
K
---------
W
R
--
G
-
E
E
V
A
V
K
---
I
F
S
S
R
----
E
-
E
-------
R
S
W
F
R
E
A
E
I
Y
Q
T
---------
V
--------
M
L
R
---
H
E
N
I
L
----
G
------
F
I
A
A
D
N
KD
N
G
------
T
----------
W
T
Q
L
W
L
V
S
--
D
Y
H
E
H
-------
G
------------
S
L
--------
F
D
Y
L
N
R
Y
--------------------------
T
----------------
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
-----------
E
------
I
V
--------------------------------------------------------------------------------------------------------------------------------------------
G
----
T
-------
Q
G
---------
K
P
--
A
--
I
----------
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
----
G
-
T
C
C
I
A
D
L
G
L
A
V
R
H
D
SATDTID
I
A
P
N
HRVGTKRYMA
P
E
V
L
D
DSINMKH
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
--
G
I
H
E
D
Y
Q
L
P
Y
Y
D
-------
L
V
P
S
D
P
S
V
E
E
M
R
-------
K
V
V
--
C
-
E
-----------
Q
-
K
-----
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
------
M
R
E
C
W
Y
A
N
G
A
A
R
----
L
T-
A
L
-------
R
I
K
K
T
L
S
Q
L
S
Q
Q
E
G
-----------------------------
47
HHSearch
57.50
16%
-19
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[26-267]
----------------------------------------------
S
Y
K
----
G
I
A
E
-----------
N
-
S
N
F
L
L
H
---------
T
T
--
K
-
D
P
L
I
L
T
---
L
Y
E
K
-------
K
-------
N
D
L
P
F
F
L
G
L
M
Q
H
L
A
-----
A
-
K
--------
G
L
S
---
C
P
L
P
L
----
P
------
R
-------
K
D
GEL
L
G
E
L
----------
S
G
R
P
A
A
L
I
--
S
F
L
E
G
-------
M
------------
W
L
--------
R
K
P
------------------------------------------------
E
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
S
E
G
-----------
F
------
E
I
K
------
R
P
NALS-
V
-----
D
----------
G
--
W
K
---------
V
L
W
D
------
K
S
E
------
E
----
R
---------
A
---
D
E
----
V
E
----
K
-------------------
G
-----
L
R
E
E
I
R
P
E
------
I
D
Y
L
A
A
H
WP-
K
-------
D
L
---------
P
A
--
G
--
V
----------
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
D
----
E
L
S
G
L
I
-
D
F
Y
F
A
C
N
D
L
------------------------------------------
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
E
K
D
----
G
-----------------
A
Y
N
V
T
K
G
K
A
L
L
-------
E
G
Y
--
Q
-
S
-----------
V
R
P
-----
L
S
E
A
E
L
E
A
L
P
L
---------------------------------------------------------------------------------------
33
Fugue
56.48
15%
52
- C3 -
-
3I1A
2
?
A:
[3-330]
------------------------------KQPIQ
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
I
----
D
I
H
T
A
Q
F
I
Q
GGADTN
A
-
F
A
Y
Q
A
D
---------
S
E
--
S
-
K
S
Y
F
I
K
---
L
K
Y
G
Y
H
---
D
---------
E
I
N
L
S
I
I
R
L
L
H
D
S
G
-----
I
-
K
--------
E
I
I
---
F
P
I
H
T
LEAK
L
------
F
-------
Q
Q
------
L
----------
K
H
F
K
I
I
A
Y
--
P
F
I
H
A
-------
P
N
GFT
Q
N
L
T
G
K
Q
W
K
Q
--------
L
G
K
V
L
R
Q
--------------------------
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
-
L
R
K
E
I
Y
S
P
K
W
R
E
I
V
R
S
F
Y
N
Q
I
E
F
D
N
-----------
S
------
D
D
K
------
L
------
T
-----
A
----------
A
--
F
K
---------
S
F
F
N
------
Q
N
S
------
A
----
A
---------
I
---
H
R
----
L
V
----
D
-------------------
T
-----
S
E
K
L
---
S
------
K
K
I
Q
P
D
------------
L
D
---------
K
Y
--
V
--
L
----------
C
H
S
D
I
H
A
G
N
V
L
V
G
N
E
----
E
-
S
I
Y
I
I
D
W
D
E
P
M
L
A
P
------------------------------------------
K
E
R
D
L
M
---------
F
I
--
G
G
G
V
G
N
V
-------------
W
N
K
P
H
E
I
Q
Y
F
Y
-------
E
G
Y
GE
I
-
N
-----------
V
D
K
-----
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
------
L
---
L
S
R
N
Q
N
N
Q
----
S
--
R
L
-------
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E--------------------
37
SP3
56.19
11%
-11
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-------------------------------------GSPAA
W
V
E
R
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
D-------
A
-
A
V
F
R
L
S
---------
A
Q
--
G
-
R
P
V
L
F
V
---
K
T
D
L
S
G
---
A
-
L
-------
N
E
L
Q
D
E
A
A
R
L
S
W
L
A
-----
T
-
T
--------
G
V
P
---
C
A
A
V
L
----
D
------
V
-------
V
T
------
E
----------
A
G
R
D
W
L
L
L
--
G
E
V
P
G
-------
Q
------------
D
L
--------
L
S
S
H
L
A
-------------------------------------------------
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
T
-----------
L
------
D
P
A
TCPFDH
Q
------
A
-----
K
----------
H
--
R
I
---------
E
R
A
R
------
T
R
M
------
E
----
A
GLVDQDDLD
E
---
E
H
----
Q
G
----
L
-------------------
A
-----
P
A
E
L
---
F
------
A
R
L
K
A
R
----
M
-------
P
D
---------
G
E
DL
V
--
V
----------
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
----
R
F
S
G
F
I
-
D
C
G
R
L
G
V
A
D
------------------------------------------
R
Y
Q
D
I
A
L
A
T
R
D
I
A
-------------------------
E
E
L
G
G
E
W
A
D
R
F
L
-------
V
L
Y
------------------
G
-----
I
A
A
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
-------------------------------------------------------------------------------
39
SP3
55.67
14%
35
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWKTVPL
E
H
L
R
I
-
S
----
R
I
K
G
G
M
S
--------
N
-
M
L
F
L
C
R
L
S
EVYPPIR
N
E
--
P
-
N
K
V
L
L
R
---
V
Y
F
N
P
E
---
T
-
E
-------
S
H
L
V
A
E
S
V
I
F
T
L
L
S
-----
E
-
R
--------
H
L
----
G
P
K
L
Y
----
G
------
I
-------
F
S
------
G
--------------
G
R
L
E
--
E
Y
I
P
S
-------
R
------------
P
L
--------
S
-------------------------------------------------
C
H
E
I
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
-----------
L
EVPIWK
E
P
D
------
Y
------
L
-----
C
----------
E
--
A
L
---------
Q
R
W
L
------
K
Q
L
------
T
----
G
---------
T
---
V
D
----
A
E
----
H
R
F
D
L
PEECGVSSVN
C
L
D
L
A
R
-----
E
L
E
F
---
L
------
R
A
H
I
S
L
----
S
-------
K
S
---------
P
V
--
T
--
F
----------
C
H
N
D
L
Q
E
G
N
I
L
L
P
-
K
----
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
------------------------------------------
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
--
I
D
E
A
P
F
Y
K
I
Q
T
E
-------
N
F
P
E
N
D
Q
M
L
E
F
F
-------
L
N
Y
--
L
-
R
-----------
E
Q
G
-----
N
T
R
E
N
E
--------
L
Y
K
K
S
E
D
------
L
---
V
Q
E
T
L
P
F
V
----
P
--
V
S
-------
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
V
G
FG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
27
Fugue
55.58
13%
29
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWKTVP
L
E
H
L
R
I
S
----
R
I
K
G
G
M
S
--------
N
-
M
L
F
L
C
R
L
S
EVYPPIR
N
E
--
P
-
N
K
V
L
L
R
---
V
Y
F
N
P
E
---
T
-
E
-------
S
H
L
V
A
E
S
V
I
F
T
L
L
S
-----
E
-
R
--------
H
L
G
PKL
Y
G
I
F
S
----
G
------
G
-------
R
L
------
E
----------
E
Y
I
P
S
R
P
L
S
C
H
E
I
S
L
-------
A
------------
H
M
--------
S
T
K
I
A
K
R
--------------------------
V
----------
A
K
-
V
H
-
Q
L
E
V
P
I
W
K
E
P
D
Y
L
C
E
A
L
Q
R
W
L
K
-----------
Q
------
L
T
G
------
T
------
V
-----
D
----------
A
--
E
H
---------
R
F
D
L
------
P
E
E
------
C
----
G
---------
V
---
S
S
----
V
N
----
C
-------------------
L
-----
D
L
A
R
---
E
------
L
E
F
L
R
A
----
H
I
S
L
S---
K
S
---------
P
V
--
T
--
F
----------
C
H
N
D
L
Q
E
G
N
I
L
L
P
-
K
----
R
-
L
V
L
I
-
D
F
E
Y
A
S
Y
N
Y
------------------------------------------
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
--
I
D
E
A
P
F
Y
K
I
Q
T
E
-------
N
F
P
E
N
D
Q
M
L
E
F
F
-------
L
N
Y
--
L
-
R
-----------
E
Q
G
NTREN
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
---
L
L
Q
V
E
L
S
P
VGFG
F
--
A
D
-------
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA-----------------------
52
HHSearch
54.72
16%
-46
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[11-210]
-------------------------------------------
Y
Y
E
L
H
E
----
T
I
G
T
G
G
F
--------
A
-
K
V
K
L
A
C
---------
H
I
LT
G
-
E
M
V
A
I
K
---
I
M
D
K
N
T
LGS
D
-
L
-------
P
R
I
K
T
E
I
E
A
L
K
N
L
R
----------------
H
Q
H
---
I
C
Q
L
Y
----
H
------
V
-------
L
E
------
T
----------
A
N
K
I
F
M
V
L
--
E
Y
C
P
G
-------
G
------------
E
L
--------
F
D
Y
I
I
S
Q
--------------------------
D
---------------
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-----------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
Y
----------
A
H
R
D
L
K
P
E
N
L
L
F
D
E
Y
----
H
K
L
K
L
I
-
D
F
G
L
C
A
K
-------------------------------------------------------
G
S
L
A
Y
A
--
A
P
E
L
I
Q
--
G
K
S
Y
-------
L
G
S
E
A
D
V
W
S
M
G
I
-------
L
L
Y
--
V
-
L
-----------
M
C
G
-----
F
L
P
F
----------------------------------------------------------------------------------------------