@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I2JNQ5_9GAMM: (2019-01-29 )
MTMPQANIIPNDWWRWSDSQPVIIKPLLGGLTNLNYLISVNHELFVLRKNSAISEALNLNRSAEAKALSRADEAGLCAPLIYYDDQHQYMVSRYLGDKTWSVSIDHNLSLLAELLRGIHQLPGIDADLNVENKISCYWQAIDAQAAFTRELISLDSAVGAHITSAKALNNGHVLCHNDLLASNLIISNKDKLYAIDWEYAAMSDPFYELAVIIEGNALNAKQQQSLLTRYLRQPISALDWQRLYHWQIIYGYLCVLWYAVQYSNGAMPNIVSEIHRQILAIKALAAKDA
Atome Classification :
(20 SA)
-------------------------------------.........10.......--.--20.-.-......30........40---------.----------.---------......50......-..-60........70..--...-...80....------------....90......-.-.100.---..---.----------.-....110....-...-------120...--...-.---------------.----.--------130---.......140.-------..------------.--------------.------------.---.-------------150------------.......--------.160---------.----......170.---......180.....--..------190.......200.......210..------------------.------.---------.---------.------------------.------------------220.......230-.-.----------.--.-------------.----------...240.......250.......260.-..-.----.-..270--.......280.......-------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------------------MTMPQANIIPND
W
W
RWSD--S--Q
P
V
-
I
-
I
K
P
L
LGGLTN
L
N
Y
L
I
S
VN---------
H
----------
E
---------
L
F
V
L
RKNSA
I
S
E
A
L-NL-NRS
A
E
A
K
A
L
SRADE--AGL-
C
A
P
L
I
Y
YDD------------
Q
H
Q
Y
M
V
S
R
YLGD-
K
-
T
W
--
S
---
V
S
---I----------D-H
N
L
S
L
L
A
E
L
L
R
-
G
I
H
-------Q--LPG--IDA-D---------------L----N--------VEN---
K
I
S
C
Y
W
Q
AID
A
-------
Q
A
------------
A
--------------
F
------------
T
---
R
-------------
E
L
-------------
I
S
L
D
S
A
V--------GA
H
I
---------
T
----
S
A
KALNN
G
H
V
---
L
CHNDLLASN
L
I
IS--NK------D
K
L
Y
A
I
D
W
E
YAAMSDP
F
Y
E
L
A
V
I
I
E------------------G------N---------A---------L------------------
N
------------------
A
K
Q
Q
Q
S
L
L
T
R
Y
L
--R-Q----------
P
--
I
-------------
S
----------
A
L
D
W
Q
R
L
Y
H
W
Q
I
I
Y
G
Y
L
C
V
L
W
Y
A
V
QYS-NG-A----
M
-
P
N
I
V
S
--
E
I
H
R
Q
I
L
A
I
K
A
L
AAKDA-------------------------------------------------------
2
PsiBlast_PDB
81.93
25%
-6
- C3 -
-
4R7B
-
?
A:
[34-302]
-----------------------------------------------------
S
Q
--
E
--
E
E
V
-
L
-
S
V
E
Q
L
G
G
M
T
N
Q
N
Y
L
A
K
T
T
---------
N
----------
K
---------
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
--
L
G
L
-
D
V
K
N
Y
L
F
D
I
------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
L
D
S
---
T
S
---
I
----------
K
-
T
K
F
D
K
I
A
P
I
L
Q
-
T
I
H
T
SAK---
E
--
L
R
G
--
E
F
A
-
P
---------------
F
----
E
--------------
E
I
K
K
Y
E
S
L
I
E
E
-------
Q
I
------------
P
--------------
Y
------------
A
---
N
--------------
Y
-------------
E
S
V
R
N
A
V
--------
F
S
L
E
---------
K
----
R
L
A
D
L
G
V
D
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
--
P
Q
------
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
------------------
E
------
S
---------
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
SD
Q
-
T
----------
P
--
V
-------------
S
----------
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-
Q
G
-
E
----
D
-
F
G
D
Y
G
---
V
N
R
Y
Q
R
A
V
K
G
L
A
S
----------------------------------------------------------
1
PsiBlast_PDB
78.82
25%
-4
- C3 -
-
4R78
2
?
A:
[34-302]
-----------------------------------------------------
S
Q
--
E
--
E
E
V
-
L
-
S
V
E
Q
L
G
G
M
T
N
Q
N
Y
L
A
K
T
T
---------
N
----------
K
---------
Q
Y
I
V
K
F
F
G
K
G
T
E
K
L
--
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
--
L
G
L
-
D
V
K
N
Y
L
F
D
I
------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
-
I
T
L
D
S
---
T
S
---
I
----------
K
-
T
K
F
D
K
I
A
P
I
L
Q
-
T
I
H
T
SAK---
E
--
L
R
G
--
E
F
A
-
P
---------------
F
----
E
--------------
E
I
K
K
Y
E
S
L
I
E
E
-------
Q
I
------------
P
--------------
Y
------------
A
---
N
--------------
Y
-------------
E
S
V
R
N
A
V
--------
F
S
L
E
---------
K
----
R
L
A
D
L
G
V
D
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
--
P
Q
------
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
------------------
E
------
S
---------
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
SD
Q
-
T
----------
P
--
V
-------------
S
----------
H
---
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-
Q
G
-
E
----
D
-
F
G
D
Y
G
---
V
N
R
Y
Q
R
A
V
K
G
L
A
S
----------------------------------------------------------
62
HHSearch
76.69
22%
-18
* C3 *
-
4R7B
-
?
A:
[38-298]
------------------------------------------------------------
E
V
L
-
S
-
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
T
---------
N
----------
K
---------
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
--
L
G
L
-
D
V
K
N
Y
L
F
D
I
------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
T
L
--
D
---
S
T
---
S
----------
I
K
T
K
F
D
K
I
A
P
I
L
Q
-
T
I
H
-------
T
--
S
A
K
--
E
L
R
G
E
---------------
F
----
A
--------
P
F
E
---
E
I
K
K
Y
E
S
L
I
E
E
-------
Q
I
------------
P
--------------
Y
----------------
A
-------------
N
Y
-------------
E
S
V
R
N
A
V
--------
F
S
L
E
---------
K
----
R
L
A
D
L
G
V
D
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
--
P
Q
------
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
------------------
E
------
S
---------
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
--
S
D
Q
----------
T
---------------------------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-
Q
G
--------
E
D
F
G
D
--
Y
G
V
N
R
Y
Q
R
A
V
K
-------------------------------------------------------------
61
HHSearch
73.98
22%
-19
- C3 -
-
4R78
2
?
A:
[38-298]
------------------------------------------------------------
E
V
L
-
S
-
V
E
Q
L
-
G
G
M
T
N
Q
N
Y
L
A
K
T
T
---------
N
----------
K
---------
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
-
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
--
L
G
L
-
D
V
K
N
Y
L
F
D
I
------------
E
A
G
I
K
V
N
E
Y
I
E
S
-
A
I
T
L
--
D
---
S
T
---
S
----------
I
K
T
K
F
D
K
I
A
P
I
L
Q
-
T
I
H
-------
T
--
S
A
K
--
E
L
R
G
E
---------------
F
----
A
--------
P
F
E
---
E
I
K
K
Y
E
S
L
I
E
E
-------
Q
I
------------
P
--------------
Y
----------------
A
-------------
N
Y
-------------
E
S
V
R
N
A
V
--------
F
S
L
E
---------
K
----
R
L
A
D
L
G
V
D
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
--
P
Q
------
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
------------------
E
------
S
---------
E
---------
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
E
--
S
D
Q
----------
T
---------------------------
P
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
-
Q
G
--------
E
D
F
G
D
--
Y
G
V
N
R
Y
Q
R
A
V
K
-------------------------------------------------------------
92
Fugue
68.21
16%
-39
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
P
--
L
--
E
H
L
-
R
-
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
---------
E
VYPPIRNEP-
N
---------
K
V
L
L
R
V
Y
F
--
N
P
E
T
-
E
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
--
R
H
L
-
G
P
K
L
Y
G
I
F
S
------------
G
G
--
R
L
E
E
Y
I
P
S
-
R
-
P
L
--
S
C
H
E
I
S
---
L
----------
A
-
H
M
S
T
K
I
A
K
R
V
A
-
K
V
H
-------
Q
LE
V
P
I
--
W
K
E
-
P
---------------
D
----
Y
--------
L
C
E
---
A
L
Q
R
W
L
K
Q
L
T
G
-------
T
V
------------
D
--------------
A
------------
E
---
H
-------------
R
F
D
L
PEECGVSSVN
C
L
D
L
A
R
E
L
--------
E
F
L
R
---------
A
----
H
I
S
L
S
K
S
P
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
----------
K
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
Q
T
E
------
N
---------
F
---------
P
------------------
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
--
R
-
E
Q
GNTRENE
L
Y
K
--
K
-------------
S
----------
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
-
L
S
-
P
VGFG
F
-
A
D
Y
G
R
--
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------------------------------------------------------
57
HHSearch
64.06
17%
-6
- C3 -
-
2QG7
-
?
D:
[109-451]
------------------------------------------------------------
D
S
L
-
E
-
F
Q
I
I
N
G
G
-
T
N
I
L
I
K
V
K
D
M
SK-------
Q
----------
A
---------
K
Y
L
I
R
L
Y
G
P
K
-
T
D
-----
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
--
K
N
I
-
A
K
K
I
Y
V
F
F
T
------------
N
--
G
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
---
R
E
D
--
I
K
---------
N
P
K
F
Q
K
L
I
A
K
N
L
K
-
L
L
H
-------
D
--
I
K
L
--
N
E
N
-
L
Y
K
E
L
Q
V
T
Q
K
V
P
G
T
R
P
S
----
F
--------
L
W
N
---
T
I
W
K
Y
F
H
L
L
N
E
-------
E
R
------------
K
--------------
K
I
C
S
F
D
A
KANIL
K
L
---
I
-------------
D
F
-------------
D
V
L
R
D
S
I
--------
V
E
V
E
---------
S
----
L
C
K
R
E
N
S
P
I
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
T
--
V
G
------
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
------------------
E
------
Y
A
G
F
N
CDWDL
T
---------
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
L
--
G
T
D
----------
D
--
E
EL-----------
I
----------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
-
H
S
-
S
----
D
-
F
D
F
I
N
--
Y
G
M
T
R
L
T
A
S
C
L
-------------------------------------------------------------
81
SP3
62.92
15%
-44
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
-
K
T
V
P
--
L
--
E
H
L
-
R
-
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
---------
E
----------
V
YPPIRNEPN
K
V
L
L
R
V
Y
F
N
P
E
T
E
S
-
H
---
L
V
A
E
S
V
I
F
T
L
L
S
E
--
R
H
L
-
G
P
K
L
Y
G
I
F
S
------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
--
S
---
C
H
E
I
S
L
----------
A
-
H
M
S
T
K
I
A
K
R
V
A
-
K
V
H
-------
Q
--
L
E
V
PI
W
K
E
-
P
---------------
D
----
Y
--------
L
C
E
---
A
L
Q
R
W
L
K
Q
L
T
G
-------
T
V
------------
D
--------------
A
------------
E
---
H
R
F
D
L
PEECGVSSV
N
C
-------------
L
D
L
A
R
E
L
--------
E
F
L
R
---------
A
----
H
I
S
L
S
K
S
P
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
--
K
R
--------
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
------------------
E
------
W
---------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
--
R
-
E
----------
Q
--
G
-------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
P
-
V
----
G
-
F
G
--
F
--
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA--------------------------------------------------
68
HHSearch
62.69
13%
-48
- C3 -
-
3MES
3
?
A:
[58-401]
---------------------------------------------
C
R
K
N
I
P
G
W
K
E
--
I
NE
S
Y
I
-
E
-
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
V
---------
N
ELKH------
P
---------
R
I
L
F
R
I
Y
G
K
H
-
V
-
K
-
F
Y
-
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
--
I
N
I
-
A
P
N
I
I
A
D
F
P
------------
E
--
G
R
I
E
E
F
I
D
G
-
E
-
P
L
--
T
---
T
K
---
Q
L
Q
--------
L
T
H
I
C
V
E
V
A
K
N
M
G
-
S
L
H
-------
I
--
I
N
S
--
K
R
A
-
D
FPSR-----------
F
----
D
KEPI----
L
F
K
---
R
I
Y
L
W
R
E
E
A
K
I
-------
Q
V
S
K
NN--------
I
--------------
D
------------
K
E
L
Y
S
-------------
K
I
-------------
L
E
E
I
D
Q
L
--------
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
S
P
A
F
S
L
V
---
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
--
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
------------------
E
------
Y
---------
I
---------
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
E
L
R
K
L
F
I
S
V
Y
L
--
S
Q
T
----------
L
--
Q
-------------
E
QVMPSQ
Q
I
V
-
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
-------
V
----
E
-
F
D
F
T
E
--
Y
A
N
T
R
F
T
H
----------------------------------------------------------------
64
HHSearch
62.02
16%
-29
- C3 -
-
1NW1
-
CKA2_CAEEL
A:
[74-416]
------------------------------------------------------------
E
H
L
-
R
-
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPPIRNE
P
----------
N
---------
K
V
L
L
R
V
Y
F
N
P
E
--
T
-
E
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
--
R
H
L
-
G
P
K
L
Y
G
I
F
S
------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
--
S
---
C
H
E
--
I
S
---------
L
A
H
M
S
T
K
I
A
K
R
V
A
-
K
V
H
-------
Q
--
L
E
V
--
P
I
W
-
K
EP-------------
D
----
Y
--------
L
C
E
---
A
L
Q
R
W
L
K
Q
L
T
G
-------
T
V
DAE
H
R
F
------
D
--------------
L
------------
P
---
E
ECGVSSV------
N
C
-------------
L
D
L
A
R
E
L
--------
E
F
L
R
---------
A
----
H
I
S
L
S
K
S
P
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
--
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
------------------
E
------
W
---------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
--
R
E
Q
----------
G
--
N
-------------
T
RENE
L
Y
K
K
S
-
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
-
L
S
-
P
----
V
G
F
G
F
A
D
--
Y
G
R
D
R
L
S
L
Y
F
--------------------------------------------------------------
58
HHSearch
61.70
17%
-3
- C3 -
-
2QG7
-
?
E:
[109-451]
------------------------------------------------------------
D
S
L
-
E
-
F
Q
I
I
N
G
-
I
T
N
I
L
I
K
V
K
D
M
SK-------
Q
----------
A
---------
K
Y
L
I
R
L
Y
G
P
K
-
T
D
E
-
I
I
-
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
--
K
N
I
-
A
K
K
I
Y
V
F
F
T
------------
N
--
G
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
---
R
E
D--
I
K---------
N
P
K
F
Q
K
L
I
A
K
N
L
K
-
L
L
H
-------
D
--
I
K
L
--
N
E
N
-
L
YKELQVTQKVPGTRP
S
----
F
--------
L
W
N
---
T
I
W
K
Y
F
H
L
L
N
E
-------
E
R
------------
K
--------------
K
ICSFDAKANILK
L
---
I
-------------
D
F
-------------
D
V
L
R
D
S
I
--------
V
E
V
E
---------
S
----
L
C
K
R
E
N
S
P
I
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
T
--
V
G
G-----
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
------------------
E
------
Y
AGFNCDWDL
T
---------
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
L
--
G
T
D
----------
D
--
E
EL-----------
I
----------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
-
H
S
-
S
----
D
-
F
D
F
I
N
--
Y
G
M
T
R
L
T
A
S
C
L
-------------------------------------------------------------
63
HHSearch
61.60
16%
-30
- C3 -
-
1NW1
-
CKA2_CAEEL
B:
[74-416]
------------------------------------------------------------
E
H
L
-
R
-
I
S
R
I
K
G
G
M
S
N
M
L
F
L
C
R
L
S
EVYPPIRNE
P
----------
N
---------
K
V
L
L
R
V
Y
F
N
P
E
--
T
-
E
S
-
H
L
V
A
E
S
V
I
F
T
L
L
S
E
--
R
H
L
-
G
P
K
L
Y
G
I
F
S
------------
G
--
G
R
L
E
E
Y
I
P
S
-
R
-
P
L
--
S
---
C
H
E
--
I
S
---------
L
A
H
M
S
T
K
I
A
K
R
V
A
-
K
V
H
-------
Q
--
L
E
V
--
P
I
W
-
K
EP-------------
D
----
Y
--------
L
C
E
---
A
L
Q
R
W
L
K
Q
L
T
G
-------
T
V
DAE
H
R
F
------
D
--------------
L
------------
P
---
E
ECGVSSV------
N
C
-------------
L
D
L
A
R
E
L
--------
E
F
L
R
---------
A
----
H
I
S
L
S
K
S
P
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
--
K
--------
R
L
V
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
------------------
E
------
W
---------
T
---------
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
L
--
R
E
Q
----------
G
--
N
-------------
T
RENE
L
Y
K
K
S
-
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
-
L
S
-
P
----
V
G
F
G
F
A
D
--
Y
G
R
D
R
L
S
L
Y
F
--------------------------------------------------------------
70
HHSearch
61.46
17%
-19
- C3 -
-
5FUT
9
CHKA_HUMAN
A:
[30-375]
------------------------------------------------------------
D
E
F
-
H
-
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
---------
D
TTATLGDEP-
R
---------
K
V
L
L
R
L
Y
G
------G
A
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
--
R
S
L
-
G
P
K
L
Y
G
I
F
P
------------
Q
--
G
R
L
E
Q
F
I
P
S
-
R
-
R
L
--
D
---
T
E
---
E
LS--------
L
P
D
I
S
A
E
I
A
E
K
M
A
-
T
F
H
-------
G
--
M
K
M
--
P
F
N
-
K
---------------
E
PK--
W
--------
L
F
G
---
T
M
E
K
Y
L
K
E
V
L
R
-------
I
K
FT----------
E
E
S
R
-----------
I
------------
K
---
K
L
H
K
----------
L
L
S------------
Y
N
L
P
L
E
L
--------
E
N
L
R
---------
S
----
L
L
E
S
T
P
S
P
V
V
---
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
--
E
G
RENSEK
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
------------------
E
------
W
---------
M
---------
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
K
Q
Q
L
H
F
I
S
S
Y
L
--
P
A
F
----------
Q
--
N
DFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
-
I
S
-
S
----
I
E
F
G
Y
M
D
--
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
---------------------------------------------------------
71
HHSearch
60.98
17%
-3
- C3 -
-
5FTG
10
CHKA_HUMAN
A:
[30-375]
------------------------------------------------------------
D
E
F
-
H
-
I
S
V
I
R
G
G
L
S
N
M
L
F
Q
C
S
L
P
---------
D
TTATLGDEP-
R
---------
K
V
L
L
R
L
Y
G
--------
E
-
A
M
V
L
E
S
V
M
F
A
I
L
A
E
--
R
S
L
-
G
P
K
L
Y
G
I
F
P
------------
Q
--
G
R
L
E
Q
F
I
P
S
-
R
-
R
L
--
D
---
T
E
---
E
LS--------
L
P
D
I
S
A
E
I
A
E
K
M
A
-
T
F
H
-------
G
--
M
K
M
--
P
F
N
-
K
---------------
E
PK--
W
--------
L
F
G
---
T
M
E
K
Y
L
K
E
V
L
R
-------
I
K
FT----------
E
E
S
R
-----------
I
------------
K
---
K
L
H
K
----------
L
L
S------------
Y
N
L
P
L
E
L
--------
E
N
L
R
---------
S
----
L
L
E
S
T
P
S
P
V
V
---
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
--
E
G
RENSEK
Q
K
L
M
L
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
------------------
E
------
W
---------
M
---------
Y
DYSYEKYPF
F
R
A
N
IRKYP
T
------------------
K
K
Q
Q
L
H
F
I
S
S
Y
L
--
P
A
F
----------
Q
--
N
DFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
-
I
S
-
S
----
I
E
F
G
Y
M
D
--
Y
A
Q
A
R
F
D
A
Y
F
H
Q
K
R
K
---------------------------------------------------------
67
HHSearch
60.86
13%
-49
- C3 -
-
3MES
2
?
B:
[58-401]
---------------------------------------------
C
R
K
N
I
P
G
W
K
E
--
I
NE
S
Y
I
-
E
-
V
K
Q
I
F
S
G
L
T
N
Q
L
F
V
V
S
I
V
---------
N
ELKH------
P
---------
R
I
L
F
R
I
Y
G
K
H
-
V
---
F
Y
-
D
S
K
V
E
L
D
V
F
R
Y
L
S
N
--
I
N
I
-
A
P
N
I
I
A
D
F
P
------------
E
--
G
R
I
E
E
F
I
D
G
-
E
-
P
L
--
T
---
T
K
---
Q
L
Q
--------
L
T
H
I
C
V
E
V
A
K
N
M
G
-
S
L
H
-------
I
--
I
N
S
--
K
R
A
-
D
FPSR-----------
F
----
D
KEPI----
L
F
K
---
R
I
Y
L
W
R
E
E
A
K
I
-------
Q
V
S
K
NNQ-------
I
--------------
D
------------
K
E
L
Y
S
-------------
K
I
-------------
L
E
E
I
D
Q
L
--------
E
E
L
I
M
GGEKFS
M
E
R
A
L
E
L
K
L
Y
S
P
A
F
S
L
V
---
F
A
H
N
D
L
Q
E
N
N
L
L
Q
T
--
Q
-------
N
N
I
R
M
I
D
Y
E
Y
S
A
I
N
F
A
G
A
D
I
A
N
Y
F
C
------------------
E
------
Y
---------
I
---------
Y
------------------
D
YCSEKQPY
F
K
F
K
YEDYPC
E
E
L
R
K
L
F
I
S
V
Y
L
--
S
Q
T
----------
L
--
Q
-------------
E
QVMPSQ
Q
I
V
-
H
I
M
T
K
A
V
E
V
F
T
L
I
S
H
I
T
W
G
L
W
S
I
A
------S
V
----
E
-
F
D
F
T
E
--
Y
A
N
T
R
F
T
H
----------------------------------------------------------------
91
Fugue
59.80
14%
-29
- C3 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
VSNVFEN
E
K
T
L
Y
I
Y
C
K
Y
V
M
L
H
Y
G
K
D
L
V
N
--
P
--
N
E
V
-
D
S
L
E
F
Q
I
I
N
G
T
N
I
L
I
K
V
K
D
M
---------
S
----------
K
---------
Q
A
K
Y
L
I
R
L
Y
G
P
T
D
E
-
I
I
-
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
--
K
N
I
-
A
K
K
I
Y
V
F
F
T
------------
N
G
--
R
I
E
E
F
M
D
G
-
Y
-
A
L
--
S
R
E
D
I
K
---
N
----------
P
-
K
F
Q
K
L
I
A
K
N
L
K
-
L
L
H
D
IKLN
E
N
L
--
Y
K
E
--
L
Q
V
-
T
---------------
Q
----
K
VPGTRPSF
L
W
N
---
T
I
W
K
Y
F
H
L
L
N
E
-------
E
R
K
KICSFDAKA
N
I
L
--------------
K
------------
L
---
I
-------------
D
F
-------------
D
V
L
R
D
S
I
--------
V
E
V
E
---------
S
----
L
C
K
R
E
N
S
P
I
V
---
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VG
E
G
------
D
S
I
S
F
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
------------------
E
------
Y
---------
A
GFNCDWDLT
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
L
--
G
-
T
----------
D
D
E
E
-------------
L
----------
I
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
S
H
I
N
W
G
L
W
S
L
L
Q
G
-
M
H
-
S
----
F
-
D
F
I
N
Y
--
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
-------------------------------------------------------
60
HHSearch
59.53
22%
-15
- C3 -
-
3DXQ
-
?
B:
[1-284]
-------------------------------------
M
M
T
D
E
A
R
A
K
L
A
A
I
P
M
L
A
------
G
Y
T
-
G
-
P
L
E
R
L
G
G
L
T
N
L
V
F
R
A
-----------------------
G
---------
D
L
C
L
R
I
P
-----------
N
R
A
N
E
A
V
A
A
R
E
A
A
K
--
A
G
V
-
S
P
E
V
L
H
V
D
P
------------
A
T
G
V
M
V
T
R
Y
I
A
G
-
A
Q
T
M
--
S
---
P
E
---
K
F
K
T
R
------
P
-
G
S
P
A
R
A
G
E
A
F
R
-
K
L
H
-------
G
--
S
G
A
--
V
F
P
F
R
---------------
F
----
E
--------
L
F
A
---
M
I
D
D
Y
L
K
V
L
S
T
-------
K
N
V
-----------
T
--------------
L
------------
P
---
A
-------------
G
Y
-------------
H
D
V
V
R
E
A
--------
G
G
V
R
---------
S
----
A
L
A
A
H
P
L
P
L
A
---
A
C
H
C
D
P
L
C
E
N
F
L
D
T
--
G
-------
E
R
M
W
I
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
------------------
E
------
G
---------
K
---------
F
------------------
N
------------------
A
N
Q
D
E
E
L
M
R
A
Y
F
--
G
G
E
----------
A
----------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
-
N
D
-
N
P---
V
-
D
D
F
R
A
--
Y
A
D
G
R
F
A
R
C
K
A
L
------------------------------------------------------------
95
Fugue
56.69
15%
-25
- C3 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
-------------------------------------
K
T
P
L
Y
E
T
L
N
E
S
S
A
V
A
L
A
V
--
K
--
L
G
L
-
T
-
L
T
C
Q
E
I
G
D
G
N
L
N
Y
V
F
H
I
Y
---------
D
----------
R
---------
A
L
I
I
K
Q
A
V
P
Y
W
P
L
T
-
I
D
-
R
A
R
I
E
S
S
A
L
I
R
Q
G
E
H
V
P
H
L
-
V
P
R
V
F
Y
S
D
T
------------
E
M
A
V
T
V
M
E
D
L
S
H
L
K
-
I
A
--
R
---
K
G
---
L
I
E
GENYPH
L
S
Q
-
H
I
G
E
F
L
G
K
T
L
F
-
Y
S
S
-------
D
--
Y
A
L
--
E
P
K
-
V
---------------
K
----
K
--------
Q
L
V
---
K
Q
F
T
N
P
E
L
C
D
I
-------
T
E
------------
R
LVFTDPFFDHDT
N
D
F
------------
E
---
E
-------------
E
L
-------------
R
P
F
V
E
K
L
W
N
N
D
S
V
K
I
E
A
A
K
---------
L
----
K
K
S
F
L
T
S
A
E
T
---
L
I
H
G
D
L
H
T
G
S
I
F
A
---
S
E
------
H
E
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
------------------
N
------
L
---------
F
---------
L
------------------
N
------------------
A
L
S
R
D
G
A
D
R
E
P
L
--
Y
-
E
----------
H
--
V
-------------
N
----------
Q
V
W
E
T
F
E
E
T
F
S
E
A
W
Q
K
D
S
L
D
--
V
Y
A
N
I
-
D
G
-
Y
----
L
-
T
D
T
L
S
--
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
T
IGLAHV
A
D
L
D
T
IVP
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
KRSEFKT
I
T
D
V
I
E
L
F
K
L
L
V
K
66
HHSearch
55.50
15%
-29
- C3 -
-
3C5I
3
?
D:
[21-353]
---------------------------------------------
C
L
E
K
V
P
E
W
N
H
FT
E
--
D
N
L
-
R
-
V
K
Q
I
L
--
L
T
N
Q
L
F
E
V
G
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
---------
R
V
L
F
R
I
Y
G
K
H
-
V
D
E
-
L
Y
-
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
--
Y
K
I
-
A
P
Q
L
L
N
T
F
N
--------------
G
G
R
I
E
E
W
L
Y
G
-
D
-
P
L
--
R
---
I
D
D
L
-
K
----------
N
P
T
I
L
I
G
I
A
N
V
L
G
-
K
F
H
-------
T
--
L
S
R
--
K
R
H
-
L
PEH------------
W
DRTP
C
--------
I
F
K
---
M
M
E
K
W
K
N
Q
L
F
K
-------
Y
K
NIE---------
K
YNCD----------
I
------------
H
---
K
Y
I
K
----------
E
S
-------------
D
K
F
I
K
F
M
--------
K
V
Y
S
---------
K
-----
S
D
N
L
A
N
T
I
V
---
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
--
N
-------
K
C
L
R
L
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
------------------
E
------
T
---------
S
---------
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
E
N
R
K
L
F
I
T
A
Y
L
--
S
N
Y
----------
L
--
D
KVVPT
P
K
L
-----
I
----------
D
E
I
L
E
A
V
E
V
Q
A
L
G
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
-
Q
T
-
K
SYN-
E
-
F
D
F
F
L
--
Y
A
E
Q
R
L
K
M
Y
D
--------------------------------------------------------------
94
Fugue
55.06
14%
-28
- C3 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------------------------------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
--
Q
--
Y
D
V
G
S
-
L
T
S
Y
K
G
I
A
E
N
S
N
F
L
L
H
T
T
K
D
P
------
L
----------
I
---------
L
T
L
Y
E
K
K
N
D
L
P
F
F
L
-
G
L
M
Q
H
L
A
A
K
G
L
S
C
P
L
P
L
--
P
R
K
-
D
G
E
L
L
G
E
L
S
------------
G
R
P
A
A
L
I
S
F
L
E
G
M
W
-
L
R
--
K
---
P
E
---
A
----------
K
-
H
C
R
E
V
G
K
A
L
A
A
M
H
L
A
-------
S
--
E
G
F
--
E
I
K
-
R
---------------
P
----
N
--------
A
L
S
---
V
D
G
W
K
V
L
W
D
K
S
-------
E
E
------------
R
--------------
A
------------
D
---
E
-------------
V
E
-------------
K
G
L
R
E
E
I
--------
R
P
E
I
---------
D
----
Y
L
A
A
H
W
P
K
D
L
PAG
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
--
G
D
------
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
------------------
A
WCFEKD
G
---------
A
---------
Y
------------------
N
------------------
V
T
K
G
K
A
L
L
E
G
Y
Q
--
S
-
V
R
P
L
S
------
E
--
A
-------------
E
----------
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
-
A
G
-
A
----
L
-
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
YGLA---------------------------------------------------
79
HHSearch
54.62
13%
-57
- C3 -
-
6EF6
2
?
A:
[44-323]
--------------------------------------------------------------
A
-
S
-
L
R
L
L
-
N
L
S
E
N
A
T
Y
L
V
E
D
G
---------
E
----------
H
---------
Q
S
I
L
R
V
H
R
Q
D
-
Y
H
Q
-
P
H
-
E
I
E
S
E
L
D
W
L
A
A
L
R
T
D-
S
D
V
T
V
P
T
V
V
P
A
R
D
GRR
V
V
T
V
D
P
A
DV
P
R
H
V
V
H
F
E
M
V
G
G
-
A
-
E
P
--
D
---
E
E
S--
L
----------
T
L
D
D
F
Q
T
L
G
R
I
T
A
-
S
L
H
-------
E
--
H
S
Q
--
R
W
T
-
R
---------------
P
----
A
G-------
F
G
R
F
S
W
D
W
E
H
C
L
G
D
T
P
R
WGRWQDA
E
G
------------
V
--------------
G
A
S
E
---------
T
---
A
-------------
L
L
-------------
T
R
A
Q
D
L
L
--------
H
R
K
L
---------
E
----
E
Y
G
S
G
P
D
R
Y
G
---
L
I
H
A
D
L
R
L
A
N
L
L
V
D
--
S
S
TPQ---
R
T
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
------------------
F
------
I
---------
E
---------
H
DPR---------------
L
------------------
G
E
W
Q
E
S
W
V
A
G
Y
R
--
S
R
R
----------
E
--
L
-------------
P
----------
A
A
D
E
A
M
L
P
S
F
V
F
L
R
R
L
L
L
L
A
W
M
G
S
H
T
H
------------------------------------------------------------------------------------------