@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : R9IMS3_9FIRM: (2019-02-02 )
MKSRTKNLLSHEDIQRLVKVNFGEEYEHKIGEIKELKGGMFNAIYLIQRVDEKNGIVLKVGVAPGRDLLTYEQDIMPTEVACYQLIKEKTSIPIPEILKYDFSKKYIDSNYFFMEELKGVPLSKASKLMNKPSLDKIKSKLAEYLVQLHKIEGNYFGYFTDEKKYQYDTWKNAFLSMFGQLLEDCKFHKVNIPYERIEQALKYNIQFLEEIKKPSLVMFDCHEGNVFVNKRNGEYEIQGIIDFERAFWGDPAADFPAAFIMSDDIRKEEAFLASYFEKSDTKKEYTRDDEIRFQMYRMYILTVMAGETFRYGPLYAKMQREWAKSGILKCLEILED
Atome Classification :
(20 SA)
---------------------------.........10.........20..----..-.-------..-----.30...--.....40.........50-------.......-.---60........70....---....80.......-.--90........100....---...110.......--120...-.-.-.---------..---------130...-....140.......150.-..---.-----------.--..160--.-------.---...-...170----------....-...--180.......-190-.--.......200-........-.-210.----..-.....-220..----.-....230.......240------------------------------------........250-.........--260-----------------..-.---.---------...270....------....280.......290......-.300.......310---------.......320....------...330....---------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------MK
S
R
T
K
N
LL
S
-
H
E
D
I
Q
R
L
V
K
VNFG----
E
E
-
Y
-------
E
H
-----
K
I
G
E
I
K
--
E
L
KG
G
M
-
F
N
A
I
Y
L
I
Q
RVD-------EKN
G
I
V
L
-
K
---
V
GVAPGRDL
L
T
YEQDI---M
P
T
E
V
A
C
Y
Q
L
I
K
E
-K--TSIP
I
P
E
I
L
K
Y
D
F
S
K
KY---IDS
N
Y
F
F
M
E
E
LKG--V-P
L
S
K
-
A
-
S
-
K
---------
L
M---------NKP
S
L
D
-
K
I
K
S
K
L
A
E
Y
L
V
Q
L
H
KIEG-
N
Y
---
F
-----------
G
--
Y
FTD---E-------
K
---
K
Y
Q-
Y
D
T
W
K
N
----------
A
F
L
S
-
M
F
G
--
Q
L
L
E
DCKFHK-V-N-I--
P
Y
E
R
I
E
Q
A
---
L
K
Y
N
I
Q
F
L
-
E
-E-IK----KP-
S
L
V
M
F
-
D
CHEG----
N
-
V
F
V
NKRNG
E
Y
E
I
Q
G
I
I
-------------------------------------
D
F
E
R
AFWGD---
P
A
ADFP
A
A
F
--
I
MS-----------------D
D
-
I
---
R
---------
K
E
E
A
F
-
L
A
S
Y
------
F
E
KSDTKKEYTR
D
D
E
I
R
F
Q
M
Y
R
M
-
Y
I
L
T
VMAGETFRYG---------
P
L
Y
A
K
M
Q
R
E
W
A
K
S
G
------
I
L
K
C
L
E
I
LED---------------
36
HHSearch
74.05
18%
-75
- C4 -
-
3W0S
2
KHYB_ECOLX
A:
[6-278]
-----------------------------------
L
T
-
A
T
S
V
E
K
F
L
I
E
K
F
D
----
S
------------------
V
S
D
L
M
--
Q
L
S
E
G
E
-
E
S
R
A
F
S
F
D
V
G
--------
G
R
-
G
Y
V
L
-
R
---
V
N
S
C
A
---------
D
G
---
F
Y
K
D
R
Y
V
Y
R
H
F
A
S
----
A
A
L
P
I
P
E
V
L
D
I
G
E
F
S
-----
E
S
L
T
Y
C
I
S
R
R
A
Q
G
--
V
-
T
L
Q
D
-
L
------------------------
P
E
T
E
L
P
-
A
V
L
Q
P
V
A
E
A
M
D
A
I
A
A
A
D
L
-
S
Q
T
S
G
F
-----------
G
--
P
F
G
P
---
Q
-------
G
---
I
G
Q
-
Y
T
T
W
R
D
----------
F
I
C
A
-
I
A
D
--
P
H
V
Y
H
W
Q
T
V
M
-
D
-
D
-
T
--
V
S
A
S
V
A
Q
A
---
L
D
E
L
M
L
W
A
-
E
D
C
-
P
E
----
V
R
-
H
L
V
H
A
-
D
F
G
S
N
----
N
-
V
L
T
D
N
----
G
R
I
T
A
V
I
-------------------------------------
D
W
S
E
A
M
F
G
D
---
S
Q
Y
E
V
A
N
I
F
--
F
W
R
-----------------
P
W
-
L
---
A
---------
C
M
E
Q
Q
-
T
R
Y
F
------
E
R
R
H
P
-----
E
L
A
G
S
P
R
L
R
A
Y
M
L
-
R
I
G
L
D
Q
L
Y
Q
S
L
---------------------------------------------------------
31
HHSearch
69.17
19%
2
- C4 -
-
3JR1
3
?
A:
[16-309]
--------------------------------
Y
F
Q
G
M
-
W
K
S
I
S
Q
V
L
A
E
Q
F
G
----
A
Y
Y
F
---------------
I
K
H
K
E
--
K
L
Y
S
G
E
-
M
N
E
I
W
L
I
N
D
E
--------
V
Q
-
T
V
F
V
-
K
---
I
N
E
R
S
Y
-------
R
S
M
---
F
R
A
E
A
D
Q
L
A
L
L
A
K
-
T
--
N
S
I
N
V
P
L
V
Y
G
I
G
N
S
------
Q
G
H
S
F
L
L
L
E
A
L
N
K
--
S
-
K
N
--------------------------------
K
Q
-
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
---
Y
-----------
G
--
L
D
F
D
---
T
W
L
GP
I
Y
Q
P
---
N
D
W
-
Q
T
S
W
A
K
----------
F
F
S
E
N
R
I
G
--
W
Q
L
Q
I
C
K
E
K
G
-
L
-
I
F
G
--
N
I
D
L
I
V
Q
I
---
V
A
D
---
T
L
-
S
K
H
-
N
P
----
K
P
-
S
I
L
H
G
-
N
L
W
I
E
----
N
-
C
I
Q
V
D
----
D
K
I
F
-
V
C
-------------------------------------
N
P
-
A
C
Y
W
G
D
---
R
E
C
D
I
A
F
S
S
--
L
F
E
------------------------
P
---------
F
P
T
N
F
-
Y
Q
R
Y
------
N
E
I
Y
P
L
----
E
E
G
Y
L
E
R
K
L
I
Y
Q
L
-
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
-
K
-----------
K
Q
-
S
Y
V
S
L
T
Q
K
L
------
I
N
Q
I
L
H
K
------------------
42
Fugue
67.28
15%
16
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
------------------T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
A
-
P
E
V
T
V
E
S
G
V
D
S
T
G
----
M
S
-
S
-------
E
T
-----
I
I
L
T
A
R
--
W
Q
Q
D
G
R
-
S
I
Q
Q
K
L
V
A
R
V
A
-------
P
---------------
A
A
E
D
V
P
V
F
P
T
Y
R
---
L
D
H
Q
F
E
V
I
R
L
V
G
E
-
L
--
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
V
---
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
-
V
-
M
-
P
---------
Y
T
FGDNWFADA
P
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
-
A
Q
---
N
-----------
T
F
S
F
L
T
D
---
T
-------
T
---
L
H
R
-
H
F
N
W
V
R
----------
S
W
Y
D
-
F
A
V
--
E
G
I
G
R
--------
S
-
P
--
L
L
E
R
T
F
E
W
---
L
Q
S
H
W
P
D
D
-
A
-
A
-
A
R
----
E
P
-
V
L
L
W
G
-
D
A
R
V
G
----
N
-
V
L
Y
R
D
F
----
Q
P
V
A
V
L
-------------------------------------
D
W
E
M
V
A
L
G
P
---
R
E
L
D
V
-
A
W
M
--
I
F
A
-----------------
H
R
-
V
---
F
---------
Q
E
L
A
G
-
L
A
T
L
PGLPEV
M
R
E
D
D
V
R
A
T
Y
Q
A
L
T
G
V
E
L
G
D
L
H
W
-
F
Y
V
Y
S
G
V
M
W
A
C
V
F
M
---------
R
T
G
A
R
R
V
H
F
G
E
I
E
K
PDDVES
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH---------
53
Fugue
65.53
17%
-1
- C4 -
-
3CSV
11
?
A:
[4-333]
-------------------------------------------------
S
R
----
E
D
-
E
-------
I
R
-----
D
F
L
A
T
H
--
G
Y
A
D
W
N
-
R
T
P
R
Y
Q
R
L
R
S
P
-------
T
G
A
K
A
V
L
M
D
---
W
S
P
E
E
G
G
D
T
-----------
Q
P
F
V
D
L
A
Q
Y
L
R
N
-
L
---
D
I
S
A
P
E
I
Y
A
E
E
--------
H
A
R
G
L
L
L
I
E
D
L
G
D
--
A
-
L
F
T
E
-
V
-------------
I
N
---------
N
D
P
A
Q
E
M
P
L
Y
R
A
A
V
D
L
L
I
H
L
H
D
A
Q
T
-
P
E
---
L
-----------
A
--
R
L
D
P
---
E
-------
T
---
L
S
E
M
T
-----------------
R
L
-
A
F
S
--
E
Y
R
Y
A
I
L
G
D
A
-
A
-
E
-
D
--
N
R
K
R
F
E
H
R
---
F
A
Q
I
L
S
A
Q
-
L
-
E
-------
G
D
M
V
F
V
H
R
-
D
F
H
A
Q
----
N
-
L
L
W
L
P
E
R
E
G
L
A
R
V
G
V
I
-------------------------------------
D
F
Q
D
A
K
L
G
H
---
R
A
Y
D
L
V
S
L
L
Q
D
A
R
R
-----------------
D
V
-
P
---
A
---------
Q
V
E
A
Q
M
I
D
H
Y
------
I
Q
A
T
G
V
D
E
S
H
F
R
S
A
Y
A
V
I
A
V
Q
R
N
M
R
I
L
G
I
F
A
R
L
S
Q
R
F
G
KR
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
H
P
A
------
L
A
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
30
HHSearch
64.84
17%
-14
- C4 -
-
5IQC
2
AACA_STAAU
A:
[7-301]
--------------------------------
D
N
A
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
F
D
----
N
F
-
K
---------------
V
D
S
I
E
--
I
I
G
S
G
Y
-
D
S
V
A
Y
L
V
N
----------
N
--
E
Y
I
F
-
K
---
T
K
F
S
T
N
------
K
K
K
G
---
Y
A
K
E
K
A
I
Y
N
F
L
N
T
-
N
LE
T
N
V
K
I
P
N
I
E
Y
S
Y
I
S
------
D
E
L
S
I
L
G
Y
K
E
I
K
G
--
T
-
F
L
T
P
E
I
-
Y
-
S
---------
T
M
---------
S
E
E
E
Q
N
-
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
-
T
D
---
I
-----------
S
--
E
C
T
I
---
D
------------
N
K
-
Q
N
V
L
E
E
-----------
Y
I
L
-
L
R
E
--
T
I
Y
N
D
L
T
------
D
-
I
--
E
K
D
Y
I
E
S
F
---
M
E
R
L
N
A
T
T
-
V
-
F
-
E
G
----
K
K
-
C
L
C
H
N
-
D
F
S
C
N
----
H
-
L
L
L
D
G
N
---
N
R
L
T
G
I
I
-------------------------------------
D
F
G
D
S
G
I
I
D
---
E
Y
C
D
F
I
Y
L
L
--
E
D
S
EEE--------------
I
G
-
T
---
N
---------
F
G
E
D
I
-
L
R
M
Y
------
G
N
I
D
------
I
E
K
A
K
E
Y
Q
D
I
V
E
E
-
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
---------
K
Q
---
E
F
I
E
N
G
R
K
E
------
I
Y
K
R
---------------------
45
Fugue
64.51
16%
8
- C4 -
-
3JR1
3
?
A:
[14-309]
-------------------------------
N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
----
A
Y
-
Y
--------------
F
I
K
H
K
E
--
K
L
Y
S
G
E
M
N
E
I
W
L
I
N
---
D
-------
E
V
Q
T
V
F
V
-
K
---
I
N
E
--------
R
S
Y
R
S
M
--
F
R
A
E
A
D
Q
L
A
L
L
A
K
-
T
--
N
S
I
N
V
P
L
V
Y
G
I
G
N
S
Q
------
G
H
S
F
L
L
L
E
A
L
N
-----------------------------------
K
S
K
N
K
Q
-
S
S
F
T
I
F
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
---
Y
-----------
G
--
L
D
F
D
---
T
-------
W
L
GP
I
Y
Q
-
P
N
D
W
Q
T
----------
S
W
A
K
-
F
F
S
--
E
N
R
I
G
W
Q
L
Q
I
-
C
-
K
-
E
--
K
G
L
I
F
G
N
I
---
D
L
I
V
Q
I
V
A
-
D
-
T
-
L
S
KHNP
K
P
-
S
I
L
H
G
-
N
L
W
I
E
----
N
-
C
I
Q
V
--
D
D
K
I
F
V
C
N
P
A
-----------------------------------------
C
Y
W
G
D
---
R
E
C
D
I
A
F
S
------------------------------
S
---------
L
F
E
P
F
-
P
T
N
F
------
Y
Q
R
Y
N
E
I
Y
P
L
E
E
G
Y
L
E
R
K
L
I
Y
Q
L
-
Y
Y
L
L
N
F
S
Y
R
Y
Y
N
K
K
---------
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
------
L
H
K
----------------------
29
HHSearch
63.90
17%
-13
- C4 -
-
5IQI
1
AACA_STAAU
C:
[9-302]
----------------------------------
A
T
N
-
V
K
A
M
K
Y
L
I
E
H
Y
F
D
----
N
F
-
K
---------------
V
D
S
I
E
--
I
I
G
S
G
Y
-
D
S
V
A
Y
L
V
N
----------
N
--
E
Y
I
F
-
K
---
T
K
F
S
T
N
------
K
K
K
G
---
F
A
K
E
K
A
I
Y
N
F
L
N
T
-
N
LE
T
N
V
K
I
P
N
I
E
Y
S
Y
I
S
------
D
E
L
S
I
L
G
Y
K
E
I
K
G
--
T
-
F
L
T
P
-
E
I
Y
-
S
---------
T
M
---------
S
E
E
E
Q
N
-
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
-
T
D
---
I
-----------
S
--
E
C
T
I
---
D
------------
N
K
-
Q
N
V
L
-
E
----------
E
Y
I
L
-
L
R
E
--
T
I
Y
N
D
L
T
------
D
-
I
--
E
K
D
Y
I
E
S
F
---
M
E
R
L
N
A
T
T
-
V
-
F
-
E
G
----
K
K
-
C
L
C
H
N
-
D
F
S
C
N
----
H
-
L
L
L
D
G
N
---
N
R
L
T
G
I
I
-------------------------------------
D
F
G
D
S
G
I
I
D
---
E
Y
C
D
F
I
Y
L
L
--
E
D
S
EEE--------------
I
G
-
T
---
N
---------
F
G
E
D
I
-
L
R
M
Y
------
G
N
I
D
------
I
E
K
A
K
E
Y
Q
D
I
V
E
E
-
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
---------
K
Q
---
E
F
I
E
N
G
R
K
E
------
I
Y
K
R
T
--------------------
34
HHSearch
63.74
15%
-56
- C4 -
-
3DXP
1
?
A:
[20-315]
----------------------------------
R
F
D
-
T
E
A
L
E
A
W
M
R
Q
H
V
E
----
G
F
-
A
--------------
G
P
L
S
V
E
--
Q
F
K
G
-
Q
-
S
N
P
T
F
K
L
V
T
P
G
-------
Q
--
T
Y
V
M
-
R
---
A
K
P
G
-----------
A
---
I
E
R
E
Y
R
V
M
D
A
L
A
G
----
T
D
V
P
V
A
K
M
Y
A
L
C
E
D
E
S
V
---
I
G
R
A
F
Y
I
M
E
F
V
S
G
--
R
-
V
L
W
D
-
Q
S
L
-
P
---------
G
M
---------
S
P
A
E
R
T
-
A
I
Y
D
E
M
N
R
V
I
A
A
M
H
T
V
D
Y
-
Q
A
---
I
-----------
G
--
L
G
D
--------------------
Y
G
K
P
G
N
----------
Y
F
Q
R
-
Q
I
E
--
R
W
T
K
Q
Y
K
L
S
E
-
T
-
E
-
S
I
P
A
M
D
S
L
M
D
W
---
L
P
Q
H
I
P
Q
--
E
-
D
-
A
D
----
L
T
-
S
I
V
H
G
-
D
Y
R
L
D
----
N
-
L
M
F
H
P
T
E
--
P
R
V
L
A
V
L
-------------------------------------
D
W
E
L
S
T
L
G
H
---
P
M
G
D
F
G
Y
H
C
--
M
S
W
HIAPGQFRGIAGLDHAA
L
G
-
I
---
P
---------
D
E
A
S
Y
-
R
K
L
Y
------
E
Q
R
T
G
R
P
----
I
--
T
G
D
W
N
F
Y
L
A
-
F
S
M
F
R
I
--------------------------------------------------------------
46
Fugue
62.28
18%
-4
- C4 -
-
3HAM
3
?
A:
[1-299]
---------------------------
M
V
N
L
D
A
E
I
Y
E
-
H
L
N
K
Q
------------------------
I
-----
K
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
------------
N
E
Q
Y
V
V
-
K
---
V
P
K
R
D
-----
S
V
R
I
S
Q
---
K
R
E
F
E
L
Y
R
F
L
E
N
C
-
K
--
L
S
Y
Q
I
P
A
V
V
Y
Q
S
----------
D
R
F
N
I
M
K
Y
I
K
G
--
E
-
R
I
T
Y
-
E
-
Q
Y
H
---------
K
L
---------
S
E
K
E
K
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
---
S
-----------
V
--
S
L
F
S
---
D
-------
A
---
L
V
N
-
K
K
D
K
F
L
----------
Q
D
K
K
-
L
L
I
--
S
I
L
E
K
-
E
Q
L
L
-
T
-
D
-
E
--
M
L
E
H
I
E
T
I
---
Y
E
N
I
L
N
N
A
-
V
-
L
-
F
K
----
Y
T
-
P
C
L
V
H
N
D
F
S
A
N
----
N
-
M
I
F
R
N
N
----
R
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
-----------------
T
D
-
D
---
F
---------
G
-
K
E
F
-
G
R
K
V
------
L
K
Y
Y
Q
H
K
A
P
E
V
A
E
R
K
A
E
L
N
D
V
Y
W
-
S
I
D
Q
I
I
Y
G
Y
E
R
K
-----------------
D
R
E
M
L
I
K
G
------
V
S
E
L
L
Q
T
Q
A
E
MFIF-----------
5
PsiBlast_PDB
61.48
27%
-4
- C4 -
-
3HAM
3
?
A:
[6-237]
--------------------------------------------------
A
----
E
I
-
Y
-------
E
H
L
N
K
Q
I
K
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
N
E
------------
Q
Y
V
V
-
K
---
V
---
P
K
R
D
S
V
R
I
S
Q
------
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
--
L
S
Y
Q
I
P
A
V
V
-------
Y
---
Q
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
-
T
Y
E
Q
-
Y
-
H
-
K
---------
L
S
---------
E
K
E
K
-
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
S--
V
-----------
S
--
L
F
S
D
ALV
N
-------
K
---
K
D
K
-
F
L
Q
D
K
K
----------
L
L
I
S
-
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
-
I
-
E
-
T
--
I
Y
E
N
I
L
N
N
AVL
F
K
Y
T
----------------
P
-
C
L
V
H
N
-
D
F
S
A
N
----
N
M
I
F
R
N
N
R
-----
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
T----------------
D
D
-
F
---
G
---------
K
E
----------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.18
27%
-6
- C4 -
-
3HAV
2
?
A:
[6-240]
--------------------------------------------------
A
----
E
I
-
Y
-------
E
H
L
N
K
Q
I
K
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
N
E
------------
Q
Y
V
V
-
K
---
V
---
P
K
R
D
S
V
R
I
S
Q
------
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
--
L
S
Y
Q
I
P
A
V
V
-------
Y
---
Q
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
-
T
Y
E
Q
-
Y
-
H
-
K
---------
L
S
---------
E
K
E
K
-
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
S--
V
-----------
S
--
L
F
S
D
A
LV
N
-------
K
---
K
D
K
-
F
L
Q
D
K
K
----------
L
L
I
S
-
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
-
I
-
E
-
T
--
I
Y
E
N
I
L
N
N
AVL
F
K
Y
T
----------------
P
-
C
L
V
H
N
-
D
F
S
A
N
----
N
M
I
F
R
N
N
R
-----
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
T----------------
D
D
-
F
---
G
---------
K
E
----------------------------------------------------------------------------------------------------------
22
HHSearch
60.89
18%
-21
- C- -
-
3N4U
-
?
A:
[4-283]
-----------------------------------
Y
T
-
F
D
Q
V
E
K
A
I
E
Q
L
Y
P
----
D
F
-
T
---------------
I
N
T
I
E
--
I
S
G
E
G
N
-
D
C
I
A
Y
E
I
-----------
N
R
-
D
F
I
F
-
K
---
F
P
K
H
S
R
------
G
S
T
N
---
L
F
N
E
V
N
I
L
K
R
I
H
N
-
K
--
L
P
L
P
I
P
E
V
V
F
T
G
M
P
S
E
T
---
Y
Q
M
S
F
A
G
F
T
K
I
K
G
--
V
-
P
L
T
P
-
L
-
L
L
N
---------
N
L
---------
P
K
Q
S
Q
N
-
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
-
S
G
---
F
-----------
K
--
S
N
L
--------------------
V
L
D
F
R
E
----------
K
I
N
E
-
D
N
K
--
K
I
K
K
L
L
S
R
E
L
-
K
-
G
-
P
--
Q
M
K
K
V
D
D
F
---
Y
R
D
I
L
E
N
E
I
Y
-
F
-
K
Y
----
Y
P
-
C
L
I
H
N
-
D
F
S
S
D
----
H
-
I
L
F
D
T
E
K
--
N
T
I
C
G
I
I
-------------------------------------
D
F
G
D
A
A
I
S
D
---
P
D
N
D
F
I
S
L
M
--
E
D
D
EE---------------
Y
G
-
M
---
E
---------
F
V
S
K
I
-
L
N
H
Y
------
K
H
K
D
I
------
P
T
V
L
E
K
Y
R
M
K
E
K
-
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
G
------------------------------------------------------
9
PsiBlast_PDB
60.75
27%
19
- C4 -
-
3UZR
5
?
A:
[27-258]
--------------------------------------------------
A
----
E
I
-
Y
-------
E
H
L
N
K
Q
I
K
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
N
E
------------
Q
Y
V
V
-
K
---
V
---
P
K
R
D
S
V
R
I
S
Q
------
K
R
E
L
E
L
Y
R
F
L
E
N
C
K
--
L
S
Y
Q
I
P
A
V
V
-------
Y
---
Q
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
-
T
Y
E
Q
-
Y
-
H
-
K
---------
L
S
---------
E
K
E
K
-
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
S--
V
-----------
S
--
L
F
S
D
A
LV
N
-------
K
---
K
D
K
-
F
L
Q
D
K
K
----------
L
L
I
S
-
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
-
I
-
E
-
T
--
I
Y
E
N
I
------
L
S
N
A
V
L
F
K
------
Y
----
T
P
-
C
L
V
H
N
-
D
F
S
A
N
----
N
M
I
F
R
N
N
R
-----
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
T----------------
D
D
-
F
---
G
---------
K
E
----------------------------------------------------------------------------------------------------------
35
HHSearch
60.68
19%
-16
- C4 -
-
4DCA
1
?
A:
[25-298]
-----------------------------------
L
D
-
A
E
I
Y
E
H
L
N
K
--------
Q
I
-
K
---------------
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
-----------
N
E
-
Q
Y
V
V
-
K
---
V
P
K
R
D
S
------
V
R
I
S
---
Q
K
R
E
L
E
L
Y
R
F
L
E
N
-
C
K-
L
S
Y
Q
I
P
A
V
V
Y
Q
----------
S
D
R
F
N
I
M
K
Y
I
K
G
--
E
-
R
I
T
Y
E
Q
-
Y
-
H
---------
K
L
---------
S
E
K
E
K
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
---
S
-----------
V
--
S
L
F
S
---
D
------------
A
L
-
V
N
K
K
D
K
----------
F
-
L
Q
-
D
K
K
--
L
L
I
S
I
L
E
K
E
Q
L
L
T
D
-
E
--
M
L
E
H
I
E
T
I
---
Y
E
N
I
L
S
N
A
V
L
-
F
-
K
Y
----
T
P
-
C
L
V
H
N
-
D
F
S
A
N
----
N
-
M
I
F
R
N
----
N
R
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
TDD--------------
F
G
-
K
---
E
---------
F
G
R
K
V
-
L
K
Y
Y
------
Q
H
K
A
P
------
E
V
A
E
R
K
A
E
L
N
D
V
-
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
------------------------------------------------------
32
HHSearch
60.32
14%
-3
- C4 -
-
3ATT
2
Y3168_MYCTU
A:
[5-317]
----------------------------------------
V
I
S
R
W
L
S
S
V
L
P
----
G
G
-
A
--------
A
-----
P
E
V
T
V
E
SG
V
D
S
T
G
M
-
S
S
E
T
I
I
L
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
-
K
L
V
A
-
R
---
V
A
P
A
A
E
-
D
V
P
V
F
P
T
Y
R
---
L
D
H
Q
F
E
V
I
R
L
V
G
E
-
L
--
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
V
---
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
-
V
-
M
-
P
YTFGDNWFA
D
A
---------
P
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
-
A
Q
---
N
-----------
T
--
F
S
F
L
---
T
---------------
D
T
T
L
H
R
-----------
H
F
N
-
W
V
R
--
S
W
Y
D
F
A
V
E
G
I
G
R
-
S
-
P
--
L
L
E
R
T
F
E
W
---
L
Q
S
H
W
P
D
D
-
A
-
A
-
A
R
----
E
P
-
V
L
L
W
G
-
D
A
R
V
G
----
N
-
V
L
Y
R
D
----
F
Q
P
V
A
V
L
-------------------------------------
D
W
E
M
V
A
L
G
P
---
R
E
L
D
V
A
W
M
I
--
F
A
H
R
V
---------------
F
Q
E
L
A
G
L
A
TLPGLPEVM
R
E
D
D
V
-
R
A
T
Y
------
Q
A
L
T
G
V
E
-------
L
G
D
L
H
W
F
Y
V
-
Y
S
G
V
M
W
A
-------------------------------------------------------------
38
HHSearch
60.19
18%
-25
- C4 -
-
4R78
2
?
A:
[21-300]
------------------------------------
M
-
E
K
I
I
K
E
K
I
S
S
L
L
S
----
Q
E
-
E
--------------
E
V
L
S
V
E
--
Q
L
-
G
G
M
-
T
N
Q
N
Y
L
A
K
T
T
N
-------
K
--
Q
Y
I
V
-
K
---
F
F
G
K
G
T
E
K
-----
L
I
N
---
R
Q
D
E
K
Y
N
L
E
L
L
K
D
----
L
G
L
D
V
K
N
Y
L
F
D
I
---------
E
A
G
I
K
V
N
E
Y
I
E
S
--
A
I
T
L
D
S
-
T
---------------------------
S
I
K
-
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
-
E
L
---
R
-----------
G
--
E
F
A
------------------
P
-
F
E
E
I
K
K
-----------
Y
E
S
-
L
I
E
--
E
Q
I
P
Y
----------
A
--
N
Y
E
S
V
R
N
A
---
V
F
S
L
E
K
R
L
-
A
-
D
L
G
V
----
D
R
-
K
S
C
H
I
-
D
L
V
P
E
----
N
-
F
I
E
S
P
Q
---
G
R
L
-
Y
L
I
-------------------------------------
D
W
E
Y
S
S
M
N
D
---
P
M
W
D
L
A
A
L
F
--
L
E
S
E----------------
F
T
-
S
---
Q
---------
E
E
E
T
F
-
L
S
H
Y
------
E
S
D
Q
T
------
P
V
S
H
E
K
I
A
I
Y
K
I
-
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
---------
E
Q
G
E
-
D
F
G
D
Y
G
V
N
R
------
Y
Q
R
A
V
K
G
L
-----------------
33
HHSearch
60.10
14%
1
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[5-317]
----------------------------------------
V
I
S
R
W
L
S
S
V
L
P
----
G
G
-
A
--------
A
-----
P
E
V
T
V
E
SG
V
D
S
T
G
M
-
S
S
E
T
I
I
L
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
-
K
L
V
A
-
R
---
V
A
P
A
A
E
-
D
V
P
V
F
P
T
Y
R
---
L
D
H
Q
F
E
V
I
R
L
V
G
E
-
L
--
T
D
V
P
V
P
R
V
R
W
I
E
T
T
G
D
V
---
L
G
T
P
F
F
L
M
D
Y
V
E
G
--
V
-
V
P
P
D
-
V
-
M
-
P
YTFGDNWFA
D
A
---------
P
A
E
R
Q
R
-
Q
L
Q
D
A
T
V
A
A
L
A
T
L
H
S
I
P
N
-
A
Q
---
N
-----------
T
--
F
S
F
L
---
T
---------------
D
T
T
L
H
R
-----------
H
F
N
-
W
V
R
--
S
W
Y
D
F
A
V
E
G
I
G
R
-
S
-
P
--
L
L
E
R
T
F
E
W
---
L
Q
S
H
W
P
D
D
-
A
-
A
-
A
R
----
E
P
-
V
L
L
W
G
-
D
A
R
V
G
----
N
-
V
L
Y
R
D
----
F
Q
P
V
A
V
L
-------------------------------------
D
W
E
M
V
A
L
G
P
---
R
E
L
D
V
A
W
M
I
--
F
A
H
R
V
---------------
F
Q
E
L
A
G
L
A
TLPGLPEVM
R
E
D
D
V
-
R
A
T
Y
------
Q
A
L
T
G
V
E
-------
L
G
D
L
H
W
F
Y
V
-
Y
S
G
V
M
W
A
-------------------------------------------------------------
57
Fugue
59.88
17%
-5
- C3 -
-
4O7O
-
MAK1_MYCTU
A:
[6-454]
TLATKLP
W
S
D
W
L
S
R
QRWYAGRNRELAT
V
K
P
G
V
V
V
A
L
R
-
H
N
L
D
L
V
L
V
D
V
T
Y
T
DG
A
T
E
R
-
Y
Q
V
L
V
G
W
D
K
A
-----
A
I
G
V
A
D
--
D
R
T
G
---
F
D
A
L
Y
D
V
A
G
P
Q
-------
F
L
L
S
L
I
V
-
S
SAV
C
G
T
S
T
G
E
V
T
F
T
R
E
P
D
V
E
L
P
F
A
A
Q
P
R
V
C
D
A
E
Q
S
-
N
--
T
S
V
I
F
D
R
R
A
I
L
K
V
F
R
R
V
SSG
I
N
P
D
I
E
L
N
R
V
L
T
R
--
A
-
G
N
P
H
-
V
-
A
-
R
---------
L
L
------------
G
A
Y
-
Q
F
G
D
A
L
A
Y
A
L
G
M
V
T
E
Y
E
A
-
N
A
---
A
E
G
W
A
M
A
T
A
S
V
R
D
--
L
F
A
E
---
G
-------
D
---
L
Y
A
-
H
E
V
G
G
D
F
A
G
E
S
Y
R
L
G
E
A
V
A
S
-
V
H
A
--
T
L
A
D
S
L
G
T
A
Q
-
A
-
T
-
F
--
P
V
D
R
M
L
A
R
---
L
S
S
T
V
A
V
V
-
P
-
E
-
L
R
----
E
Y
-
A
P
T
I
E
-
Q
Q
F
Q
K
L
A
A
E
A
-
I
T
V
Q
R
V
H
G
D
L
H
L
G
Q
V
L
R
T
PE
S
W
L
L
I
DFEGEPGQP
L
D
E
R
R
A
P
D
S
P
L
R
D
V
A
G
V
L
R
S
F
E
Y
A
A
Y
G
P
LVD
Q
A
T
D
K
Q
L
A
A
--
R
A
R
-----------------
E
W
-
V
---
E
---------
R
N
R
A
A
-
F
C
D
G
------
Y
A
V
A
S
--
G
I
D
P
R
D
S
A
L
L
L
G
A
Y
E
L
-
D
K
A
V
Y
E
T
G
Y
E
T
R
H
R
---------
P
G
W
--------
L
P
I
------
P
L
R
S
I
A
R
L
T
A
---------------
10
PsiBlast_PDB
59.74
27%
22
- C4 -
-
4DCA
1
?
A:
[27-258]
--------------------------------------------------
A
----
E
I
-
Y
-------
E
H
L
N
K
Q
I
K
I
N
E
L
R
--
Y
L
S
S
G
D
-
D
S
D
T
F
L
C
N
E
------------
Q
Y
V
V
-
K
---
V
---
P
K
R
D
S
V
R
I
S
Q
------
K
R
E
L
E
L
Y
R
F
L
E
N
C
K
--
L
S
Y
Q
I
P
A
V
V
-------
Y
---
Q
S
D
R
F
N
I
M
K
Y
I
K
G
E
R
I
-
T
Y
E
Q
-
Y
-
H
-
K
---------
L
S
---------
E
K
E
K
-
D
-
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
-
D
C
S--
V
-----------
S
--
L
F
S
D
A
LV
N
-------
K
---
K
D
K
-
F
L
Q
D
K
K
----------
L
L
I
S
-
I
L
E
K
E
Q
L
L
T
D
E
M
L
E
H
-
I
-
E
-
T
--
I
Y
E
N
I
------
L
S
N
A
V
L
F
K
------
Y
----
T
P
-
C
L
V
H
N
-
D
F
S
A
N
----
N
M
I
F
R
N
N
R
-----
L
F
G
V
I
-------------------------------------
D
F
G
D
F
N
V
G
D
---
P
D
N
D
F
L
C
L
L
--
D
C
S
T----------------
D
D
-
F
---
G
---------
K
E
----------------------------------------------------------------------------------------------------------
37
HHSearch
59.73
18%
-25
- C4 -
-
4R7B
-
?
A:
[21-300]
------------------------------------
M
-
E
K
I
I
K
E
K
I
S
S
L
L
S
----
Q
E
-
E
--------------
E
V
L
S
V
E
--
Q
L
-
G
G
M
-
T
N
Q
N
Y
L
A
K
T
T
N
-------
K
--
Q
Y
I
V
-
K
---
F
F
G
K
G
T
E
K
-----
L
I
N
---
R
Q
D
E
K
Y
N
L
E
L
L
K
D
----
L
G
L
D
V
K
N
Y
L
F
D
I
---------
E
A
G
I
K
V
N
E
Y
I
E
S
--
A
I
T
L
D
S
-
T
---------------------------
S
I
K
-
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
-
E
L
---
R
-----------
G
--
E
F
A
------------------
P
-
F
E
E
I
K
K
-----------
Y
E
S
-
L
I
E
--
E
Q
I
P
Y
----------
A
--
N
Y
E
S
V
R
N
A
---
V
F
S
L
E
K
R
L
-
A
-
D
L
G
V
----
D
R
-
K
S
C
H
I
-
D
L
V
P
E
----
N
-
F
I
E
S
P
Q
---
G
R
L
-
Y
L
I
-------------------------------------
D
W
E
Y
S
S
M
N
D
---
P
M
W
D
L
A
A
L
F
--
L
E
S
E----------------
F
T
-
S
---
Q
---------
E
E
E
T
F
-
L
S
H
Y
------
E
S
D
Q
T
------
P
V
S
H
E
K
I
A
I
Y
K
I
-
L
Q
D
T
I
W
S
L
W
T
V
Y
K
E
---------
E
Q
G
E
-
D
F
G
D
Y
G
V
N
R
------
Y
Q
R
A
V
K
G
L
-----------------