@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : A6TJ01_KLEP7_: (2019-02-05 )
MSHIQRETSCSRPRLNSNLDADLYGYRWARDNVGQSGATIYRLYGKPNAPELFLKHGKGSVANDVTDEMVRLNWLTAFMPLPTIKHFIRTPDDAWLLTTAIPGKTAFQVLEEYPDSGENIVDALAVFLRRLHSIPVCNCPFNSDRVFRLAQAQSRMNNGLVDASDFDDERNGWPVEQVWKEMHKLLPFSPDSVVTHGDFSLDNLIFDEGKLIGCIDVGRVGIADRYQDLAILWNCLGEFSPSLQKRLFQKYGIDNPDMNKLQFHLMLDEFF
Atome Classification :
(39 SA)
.........10........20........30........40........50......----.---.60--.--........70....-..-.-.80........90....--....100..--.....110...--....120.......130.......140..----.....150.......160.--...--.....170.......180.....-.------.190.......200.......--210.......220.......230.....-----.-.--240-...--.....250--...--.---....260.......270------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSH
I
Q
RETSCSRPRLNSNLDADLY
G
Y
RWARDNVGQSG
A
T
I
Y
R
LYGKPNAP
E
L
F
L
KHG----K---GS---V--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-F-MP
L
P
T
I
K
H
F
IRTPDD
A
W
--
L
L
T
TAIP
G
K
--
T
A
F
Q
V
L
E
EYPD--SG
E
N
I
V
D
A
L
A
V
F
L
R
R
L
HSIPVCNCPFN
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
MNNGL--V--DAS--DFDDERNGW
P
V
E
Q
V
W
K
E
M
H
K
LLP-F------SPDS
V
V
THGDFS
L
D
N
L
IFDEG--
K
L
I
G
C
I
DVGRVG
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----E-F--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y---GID--N---PDMN
K
L
Q
F
H
L
M
L
D
EFF-------------------------------
27
Blastp_CBE
98.35
100%
-120
- C3 -
-
4FEV
3
?
D:
[2-272]
M
S
H
I
Q
R
E
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
51
HHSearch
98.14
100%
-116
- C3 -
-
4GKI
1
?
C:
[2-272]
M
S
H
I
Q
R
E
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
7
PsiBlast_PDB
97.85
97%
-121
- C3 -
-
4GKI
5
?
A:
[3-272]
-
S
H
I
Q
R
E
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
3
PsiBlast_PDB
96.54
97%
-114
- C3 -
-
4EJ7
2
?
A:
[23-292]
-
S
H
I
Q
R
E
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
26
Blastp_CBE
95.18
100%
-102
- C3 -
-
4FEV
3
?
E:
[3-272]
-
S
H
I
Q
R
E
T
S
C
S
R
P
R
L
N
--
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
23
Blastp_CBE
95.06
100%
-118
- C3 -
-
4FEX
2
?
C:
[9-272]
-------
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
---
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
1
PsiBlast_PDB
94.93
100%
-115
- C3 -
-
4FEV
2
?
A:
[6-272]
----
Q
R
E
T
S
C
S
R
P
----
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
24
Blastp_CBE
94.89
100%
-123
- C3 -
-
4FEX
2
?
B:
[4-272]
--
H
I
Q
R
E
T
S
C
S
R
P
R
-----
D
A
D
L
Y
G
Y
R
W
A
R
D
N
---
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
5
PsiBlast_PDB
94.23
97%
-107
- C3 -
-
4FEW
2
?
A:
[7-272]
-----
R
E
T
S
C
S
R
P
R
L
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
28
Blastp_CBE
93.98
100%
-112
- C3 -
-
4FEV
2
?
C:
[19-272]
-----------------
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
25
Blastp_CBE
93.66
100%
-122
- C3 -
-
4FEV
2
?
F:
[17-272]
---------------
N
S
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
----
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
52
HHSearch
92.90
100%
-112
- C3 -
-
4GKH
2
?
A:
[19-272]
-----------------
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
6
PsiBlast_PDB
92.30
97%
-112
- C3 -
-
4GKH
2
?
A:
[19-272]
-----------------
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
4
PsiBlast_PDB
92.15
97%
-109
- C3 -
-
4FEU
2
?
A:
[20-272]
------------------
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
2
PsiBlast_PDB
92.06
100%
-112
- C3 -
-
4FEX
3
?
A:
[19-272]
-----------------
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
21
Blastp_CBE
91.58
100%
-103
- C3 -
-
4FEX
3
?
E:
[19-272]
-----------------
N
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
22
Blastp_CBE
91.51
100%
-102
- C3 -
-
4FEX
2
?
D:
[20-272]
------------------
L
D
A
D
L
Y
G
Y
R
W
A
R
D
N
V
G
Q
S
G
A
T
I
Y
R
L
Y
G
K
P
N
A
P
E
L
F
L
K
H
G
----
K
---
G
S
---
V
--
A
N
D
V
T
D
E
M
V
R
L
N
W
L
-
T
A
-
F
-
M
P
L
P
T
I
K
H
F
I
R
T
P
D
D
A
W
--
L
L
T
T
A
I
P
G
K
--
T
A
F
Q
V
L
E
E
Y
P
D
--
S
G
E
N
I
V
D
A
L
A
V
F
L
R
R
L
H
S
I
P
V
C
N
C
P
F
N
S
D
----
R
V
F
R
L
A
Q
A
Q
S
R
M
N
N
G
L
--
V
--
D
A
S
--
D
F
D
D
E
R
N
G
W
P
V
E
Q
V
W
K
E
M
H
K
L
L
P
-
F
------
S
P
D
S
V
V
T
H
G
D
F
S
L
D
N
L
I
F
D
E
G
--
K
L
I
G
C
I
D
V
G
R
V
G
I
A
D
R
Y
Q
D
L
A
I
L
W
N
C
L
G
-----
E
-
F
--
S
P
--
S
L
Q
--
K
R
L
F
Q
K
Y
---
G
I
D
--
N
---
P
D
M
N
K
L
Q
F
H
L
M
L
D
E
F
F
-------------------------------
76
SP3
60.92
31%
-26
* C3 *
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-------------
G
S
P
A
A
W
V
E
R
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
-
G
R
P
V
L
F
V
K
T
D
----
L
---
S
G
---
A
--
L
N
E
L
Q
D
E
A
A
R
L
S
W
L
-
A
T
T
G
-
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
--
L
L
L
G
E
V
P
G
Q
--
D
L
L
S
S
H
L
A
------
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
--
D
Q
D
--
D
L
D
E
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
-
D
------
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
--
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
-----
E
E
L
--
G
G
--
E
W
A
--
D
R
F
L
V
L
Y
---
G
I
A
--
A
---
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
-------------------------------
8
PsiBlast_PDB
58.86
35%
-23
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[19-264]
----------------------
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
-
G
R
P
V
L
F
V
K
T
D
----
L
---
S
G
---
A
--
L
N
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
-
G
-
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
--
L
L
L
G
E
V
P
G
Q
-----
D
L
L
S
S
H
L
A
--
P
A
E
K
-
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
--
D
Q
D
--
D
L
D
E
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
-
D
------
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
--
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E
----
E
-
L
--
G
G
--
E
W
A
--
D
R
F
L
V
L
Y
---
G
I
A
--
A
---
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
-------------------------------
55
HHSearch
58.62
35%
-36
- C- -
-
4H05
-
?
A:
[9-267]
-------------------
R
G
R
Y
P
G
C
E
W
V
V
V
E
D
G
A
S
G
A
G
V
Y
R
L
R
G
G
-
G
-
R
E
L
F
V
K
V
A
----
A
---
L
G
---
A
--
G
V
G
L
L
G
E
A
E
R
L
V
W
L
-
A
E
-
V
G
I
P
V
P
R
V
V
E
G
G
G
D
E
R
V
A
W
--
L
V
T
E
A
V
P
G
R
--
P
A
S
A
R
W
P
R
--
E
--
Q
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
L
D
W
E
R
C
P
F
D
R
S
----
L
A
V
T
V
P
Q
A
A
R
A
V
A
E
G
S
--
V
--
D
L
E
--
D
L
D
E
E
R
K
G
W
S
G
E
R
L
L
A
E
L
E
R
T
R
P
-
A
------
D
E
D
L
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
R
TC
E
V
T
G
L
I
D
V
G
R
V
G
R
A
D
R
H
S
D
L
A
L
V
L
R
E
L
A
HEEDP
W
-
F
--
G
P
--
E
C
S
--
A
A
F
L
R
E
Y
---
G
R
G
--
W
D
G
A
V
S
E
E
K
L
A
F
Y
R
L
L
D
E
F
F
-------------------------------
53
HHSearch
57.92
34%
-20
- C3 -
-
1ND4
1
KKA2_KLEPN
A:
[24-264]
---------------------------
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
G
R
-
P
V
L
F
V
K
T
D
----
L
---
S
G
---
A
--
L
N
E
L
Q
D
E
A
A
R
L
S
W
L
-
A
T
-
T
G
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
--
L
L
L
G
E
V
P
G
Q
--
D
L
L
S
S
H
L
------
A
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
--
D
Q
D
--
D
L
D
E
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
-
D
------
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
--
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E
----
E
-
L
--
G
G
--
E
W
A
--
D
R
F
L
V
L
Y
---
G
I
A
--
A
---
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
-------------------------------
29
Blastp_CBE
57.86
35%
-20
- C3 -
-
1ND4
1
KKA2_KLEPN
B:
[19-264]
----------------------
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
A
Q
-
G
R
P
V
L
F
V
K
T
D
----
L
---
S
G
---
A
--
L
N
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
-
G
-
V
P
C
A
A
V
L
D
V
V
T
E
A
G
R
D
W
--
L
L
L
G
E
V
P
G
Q
-----
D
L
L
S
S
H
L
A
--
P
A
E
K
-
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
C
P
F
D
H
Q
----
A
K
H
R
I
E
R
A
R
T
R
M
E
A
G
L
--
V
--
D
Q
D
--
D
L
D
E
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
-
D
------
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
G
--
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
A
E----
E
-
L
--
G
G
--
E
W
A
--
D
R
F
L
V
L
Y
---
G
I
A
--
A
---
P
D
S
Q
R
I
A
F
Y
R
L
L
D
E
F
F
-------------------------------
77
SP3
55.12
27%
-1
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
--
E
N
E
N
L
Y
L
K
M
T
----
D
SRY
K
G
---
T
--
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
--
L
L
M
S
E
A
D
G
V
--
L
C
S
E
E
Y
E
D
E
-
Q
--
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
DV
D
C
E
--
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
P
--------
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
EE
Q
Y
V
--
E
L
F
F
D
L
L
---
G
I
K
------
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
37
Fugue
55.09
28%
2
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
L
Y
L
K
M
T
D
S
----
R
Y--
K
G
---
T
--
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
--
L
L
M
S
E
A
D
G
V
--
L
C
S
E
E
Y
E
D
-
E
Q
--
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
AD
V
--
D
C
E
--
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
K
P
--------
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
IG
E
E
--
Q
Y
V
--
E
L
F
F
D
L
L
---
G
I
K
------
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
56
HHSearch
54.64
29%
2
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[7-263]
----------------
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
--
E
N
L
Y
L
K
M
T
----
D
---
S
R
YKG
T
--
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
--
L
L
M
S
E
A
D
G
V
--
L
C
S
E
E
Y
E
D
E
-
Q
--
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
D
CE
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
-
K
-
P
------
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
D
I
G-
E
E
--
Q
Y
V
--
E
L
F
F
D
L
L
---
G
I
K
------
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
32
Blastp_CBE
54.43
31%
13
- C3 -
-
1J7U
1
KKA3_ENTFL
B:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
DSRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
SN
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
LKTEKP
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
YV
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
17
PsiBlast_PDB
53.79
30%
8
- C3 -
-
3TM0
2
KKA3_ENTFL
A:
[1-263]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
33
Blastp_CBE
53.69
31%
13
- C3 -
-
1J7L
1
KKA3_ENTFL
B:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
DSRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
SN
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
LKTEKP
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
YV
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
57
HHSearch
53.66
29%
1
- C3 -
-
1L8T
2
KKA3_ENTFL
A:
[7-263]
----------------
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
--
E
N
L
Y
L
K
M
T
----
D
---
S
R
YKG
T
--
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
D
G
W
S
N
--
L
L
M
S
E
A
D
G
V
--
L
C
S
E
E
Y
E
D
E
-
Q
--
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
D
CE
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
-
K
-
P
------
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
D
I
G-
E
E
--
Q
Y
V
--
E
L
F
F
D
L
L
---
G
I
K
------
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
31
Blastp_CBE
53.01
31%
13
- C3 -
-
3Q2J
1
KKA3_ENTFL
B:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
13
PsiBlast_PDB
52.69
30%
12
- C3 -
-
1J7U
1
KKA3_ENTFL
A:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
14
PsiBlast_PDB
52.47
30%
9
- C3 -
-
3Q2J
1
KKA3_ENTFL
A:
[4-264]
------------
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
15
PsiBlast_PDB
52.43
30%
10
- C3 -
-
1L8T
2
KKA3_ENTFL
A:
[1-263]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
16
PsiBlast_PDB
51.57
30%
11
- C3 -
-
2B0Q
2
KKA3_ENTFL
A:
[1-263]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
KP
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
12
PsiBlast_PDB
51.15
30%
11
- C3 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
C
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
30
Blastp_CBE
50.49
31%
17
- C3 -
-
2BKK
1
KKA3_ENTFL
C:
[3-264]
-----------
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
S
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
DSRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
D
L
--
A
--
D
V
-------
D
S
E
N
W
E
E
D
T
P
F
K
D
P
R
E
L
Y
D
-
F
L
K
TEKP
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
10
PsiBlast_PDB
50.37
30%
6
- C3 -
-
2BKK
1
KKA3_ENTFL
A:
[2-264]
----------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
S
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
G
E
N
E
N
--
L
Y
L
K
M
T
D
SRY
K
---
G
T
---
T
--
Y
-
D
V
E
R
E
K
D
M
M
L
W
L
-
E
G
-
K
-
L
P
V
P
K
V
L
H
F
E
R
H
--
D
G
W
S
N
L
L
M
S
E
A
D
G
V
--
L
C
S
---
E
E
Y
E
D
EQ
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
C
P
Y
T
N
S
----
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
---------------------------
K
D
P
R
E
L
Y
D
-
F
L
K
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
G
--
K
V
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
-----
E
-
D
--
I
G
--
E
E
Q
Y
V
E
L
F
F
D
L
L
---
G
I
---
K
---
P
D
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
-------------------------------
38
Fugue
33.52
15%
-17
- C3 -
-
3HAM
3
?
A:
[1-299]
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
E
Q
Y
V
V
K
V
P
K
R
D
-------------------
S
---
V
--
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
-
E
N
---
C
K
L
S
Y
Q
I
P
A
V
V
Y
Q
S
D
R
F
--
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
K
L
S
E
K
--
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
F
S
DALV
N
K
K
D
K
F
L
Q
D
K
K
L
L
I
S
I
--
L
--
E
K
E
--
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
A
V
-
L
F-----
K
Y
T
P
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
N
--
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
T
-----
D
-
D
--
F
G
--
K
E
F
--
G
R
K
V
L
K
Y
Y
QH
K
A
P
--
E
---
V
A
E
R
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
KD
R
E
M
L
I
K
G
V
S
E
L
L
Q
TQAEMFIF
59
HHSearch
32.63
17%
4
- C3 -
-
4R78
2
?
A:
[40-268]
-------------------------
L
S
V
E
Q
L
-
G
G
-
M
T
N
Q
N
Y
L
A
K
T
T
N
--
K
Q
Y
I
V
K
F
F
----
G
---
K
G
---
T
EK
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
-
K
D
-
L
G
L
D
V
K
N
Y
L
F
D
I
---
E
A
G
I
--
K
V
N
E
Y
I
E
S
A
I
-
T
L
D
S
T
S
--------
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
R
G
E
F
A
-----
P
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q
I
--
P
---
Y
-----
A
---
N
Y
E
S
V
R
N
A
V
F
S
L
E
K
R
L
A
D
L
------
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
Q
--
G
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
------
E
-
F
--
T
S
--
Q
E
E
--
E
T
F
L
S
H
Y
---
E
S
D
Q
T
P
---
V
S
H
E
K
I
A
I
Y
K
I
L
Q
D
---------------------------------