@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q21D31_RHOPB: (2019-02-01 )
MDDATDELATLIARGLGVLRPKRLHAGAEAVAYELDDARVLKVYHAGGSAERFATIASFYARLNSDRAGFAVPRILTHGVEGGRAYSVEKRLLGEPLSTRAHFLTDTDLIDAYLAAALRVGRIQVEPEWNSWTMFGEQRHGDWHQHVRGQIESQSRALARMLQPAYWERLANATADVRQHFDRPFLGKVCLIHGDFHPGNVLVGATGRVLSLVDFGAFTTFGDAAFDVATACGYFSMYEPDQATTRRSLVARLLRMEGSPPGALVAMYLKLAAFLTCTAYPDDRVAVQDTGHFQWAMSVLFDPMLDELVDRVPH
Atome Classification :
(20 SA)
-----------------.........10...-...----.---.20....----...---.30....--.----.----.---------.--40......-..-.-50.-....-...60....-.-.-..70..-------------......-----80.----------........90...-.....100--.----------...-....110.......120-..----...-..130--.----........-140..--......150..-....-..160.--.....--...170--.......180-----.-.---.--.-....----190.......200...---.-.---..210--------.......220.......230.-------------...-----..--.--240.--......-250....--..--.260--.-----........---------270.....-..280.......290.-......300-------....--....310..---------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------------MDD
A
T
D
E
L
A
T
L
I
A
R
-
G
L
G----V---L
R
P
K
R
LH----AGA---
E
A
V
A
Y
EL--D----D----
A
---------
R
--
V
-
L
K
V
Y
HA-GG-
S
-
A
E
R
-
F
A
T
I
-
A
S
F
Y
A
R
LNS-D-R-AGF
A
V
P
-------------
R
I
L
T
HG-----V-E----------G
G
R
A
Y
S
V
E
K
R
L
LG-EPL
S
T
R
A
---
H
----------FLT-
D
T
D
L
I
D
A
Y
L
A
A
A
LRV
G
R
-
I
Q
----VEP-EWN----
S
----
W
T
M
FGEQR-HG-
D
W
--
H
Q
H
V
R
G
Q
-
I
E
S
-
Q
S
R
A
-
L
A
R
--
M
--L
Q
P
A
Y
--
W
E
R
L
A
N
--
A
T
A
D
V
R
Q
HF------D-R---P--F-L
G
K
V
----
C
L
I
H
GDFHPG
N
V
L
VGA---T-
G
---
R
V
L
S
L
--------
V
DFGAFTTFG
D
A
A
F
D
V
A
T
A
CG-------------YFS-----MY--E--PDQ
A
--
T
T
R
R
S
L
-
V
A
R
L
L
RM--EG--SP----
P
-----
G
A
L
V
A
M
Y
L
---------
K
L
A
A
F
L
TC-TAYPDD
R
V
A
V
QDTG
H
F
-
Q
W
A
M
S
V
L
F
--------
D
P
M
L
--
D
E
L
V
D
RVPH---------------
97
Fugue
72.24
13%
-62
- C2 -
-
3HAM
3
?
A:
[1-299]
-----------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
-
Q
I
K
----
I
---
N
E
L
R
Y
L
S
----
S
G
D
---
D
S
D
T
F
L
C
--
N
----
E
----
Q
---------
Y
--
V
-
V
K
V
P
K
R
-
D
S
-
V
-
R
I
S
-
Q
K
R
E
-
F
E
L
Y
R
F
L
E
N
-
C
-
K
-
L
S
Y
Q
I
P
-------------
A
V
V
Y
Q
S
--------------------
D
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
--
H
----------
K
L
S
-
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
-
L
H
----
S
I
E
-
I
D
C
----
S
----
V
S
L
F
S
D
A
L
-
V
N
-
K
K
--
D
K
F
L
Q
D
K
-
K
L
L
-
I
S
I
L
-
E
K
E
--
Q
--
L
L
T
D
E
--
M
L
E
H
I
E
--
T
I
Y
E
N
I
L
N
N
------
A
-
V
---
L
--
F
-
K
Y
T
P
----
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
----
N
-
N
---
R
L
F
G
V
--------
I
D
F
G
D
F
-
N
V
G
D
P
D
N
D
F
L
C
L
L
D
-------------
C
S
T
---------------
D
--
D
F
G
K
E
F
-
G
R
K
V
L
K
Y
--
Y
Q
--
H
K
----
A
-----
P
E
V
A
E
R
K
A
---------
E
L
N
D
V
Y
W
S
-
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
-
I
K
G
V
S
E
L
L
--------
Q
T
Q
A
--
E
M
F
I
F
-------------------
89
SP3
71.99
19%
5
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANT
I
P
E
L
K
E
R
A
H
M
L
C
A
R
-
F
L
G
GAWK
T
---
V
P
L
E
H
L
R
I
S
R
I
K
G
G
MS
N
M
L
F
L
C
R
L
--
S
----
E
----
V
YPPIRNEPN
K
--
V
-
L
L
R
V
Y
F
-
N
P
-
E
-
T
E
S
-
H
L
V
A
-
E
S
V
I
F
T
L
L
S
-
E
-
R
--
H
L
G
-
P
-------------
K
L
Y
G
I
------
F
-
S
----------
G
G
R
L
E
E
Y
---
I
P
S
-
R
P
L
S
C
-----
H
----------
E
I
S
-
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
-
L
E
----
V
-
P
-
I
W
K
----
E
PD
Y
L
C
E
A
L
Q
R
-------
W
--
L
K
Q
L
T
G
T
-
V
D
A
-
E
H
R
F
D
L
P
E
--
E
--
C
G
V
S
S
VN
C
L
D
L
A
R
--
E
L
E
F
L
R
A
H
I
------
S
-
L
------
S
-
K
S
P
V
----
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
-----
P
-
K
---
R
-
L
V
L
--------
I
D
F
-
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
IDYDIDEAPF
Y
K
I
-----
Q
T
--
E
NF
P
E
N
D
--
Q
M
L
E
F
F
-
L
N
Y
L
R
E
Q
--
G
N
--
T
R
ENE
L
Y
-----
K
K
S
E
D
L
V
Q
---------
E
T
L
P
F
V
P
V
-
S
-------------
H
F
-
F
W
G
V
W
G
L
L
Q
V
ELSPVG
F
G
F
A
--
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA---
70
HHSearch
70.91
20%
-21
- C- -
-
4H05
-
?
A:
[1-265]
-----------------
M
D
D
A
L
R
A
L
R
G
R
-
Y
P
-
G
C
E
----
W
-----
V
V
V
E
D
----
G
A
S
---
G
A
G
V
Y
R
L
--
R
----
G
GG
R
-
E
---------
L
--
F
-
V
K
V
A
A
L
-
G
A
---
G
V
G
-
L
L
G
E
-
A
E
R
L
V
W
L
A
E
-
V
----
G
I
P
V
P
-------------
R
V
V
E
G
G
-----
G
-
D
----------
E
R
V
A
W
L
V
T
E
A
V
P
G
-
R
P
A
S
A
R
W
---
P
----------
R
E
Q
-
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
-
L
D
----
W
E
R
--------
C
----
P
F
D
R
S
L
A
V
T
V
P
-
Q
A
--
A
R
A
V
A
E
G
------
S
V
D
-
L
E
D
--
L
--
D
-
E
E
R
--
K
---
G
W
--
S
G
E
R
L
L
A
E
L
------
E
-
R
---
T
R-
P
A
D
E
D
L
----
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
---
R
T
C
---
E
V
T
G
L
--------
I
D
V
G
R
-
V
G
R
A
D
R
H
S
D
L
A
L
V
L
R
-------------
E
L
A
HEEDP
W
F
--
G
--
P
E
C
S
--
A
A
F
L
R
E
-
Y
G
-
R
G
W
D
--
G
A
--
V
S
----------
E
E
K
L
A
F
Y
R
---------
L
L
D
E
--------------------------------------------------------------------
71
HHSearch
70.13
20%
-25
- C- -
-
4H05
-
?
B:
[1-265]
-----------------
M
D
D
A
L
R
A
L
R
G
R
-
Y
P
-
G
C
E
----
W
-----
V
V
V
E
D
----
G
A
S
---
G
A
G
V
Y
R
L
--
R
----
G
GG
R
-
E
---------
L
--
F
-
V
K
V
A
A
L
-
G
A
---
G
V
G
-
L
L
G
E
-
A
E
R
L
V
W
L
A
E
-
V
----
G
I
P
V
P
-------------
R
V
V
E
G
G
-----
G
-
D
----------
E
R
V
A
W
L
V
T
E
A
V
P
G
-
R
P
A
S
A
R
W
---
P
----------
R
E
Q
-
R
L
D
V
A
V
A
L
A
G
L
A
R
S
L
H
A
-
L
D
----
W
E
R
--------
C
----
P
F
D
R
S
L
A
V
T
V
P
-
Q
A
--
A
R
A
V
A
E
G
------
S
V
D
-
L
E
D
--
L
--
D
-
E
E
R
--
K
---
G
W
--
S
G
E
R
L
L
A
E
L
------
E
-
R
---
T
R-
P
A
D
E
D
L
----
A
V
C
H
G
D
L
C
P
D
N
V
L
L
D
P
---
R
T
C
---
E
V
T
G
L
--------
I
D
V
G
R
-
V
G
R
A
D
R
H
S
D
L
A
L
V
L
R
-------------
E
L
A
HEEDP
W
F
--
G
--
P
E
C
S
--
A
A
F
L
R
E
-
Y
G
-
R
G
W
D
--
G
A
--
V
S
----------
E
E
K
L
A
F
Y
R
---------
L
L
D
E
--------------------------------------------------------------------
103
Fugue
68.07
19%
0
- C2 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
------------SAFT
F
Q
T
L
H
P
D
T
I
M
D
A
L
F
E
H
G
I
R
----
V
---
D
S
G
L
T
P
L
----
N
S
Y
---
E
N
R
V
Y
Q
F
--
Q
D
EDR
R
----
R
---------
F
--
V
-
V
K
F
Y
R
P
-
E
R
W
T
-
A
D
Q
-
I
L
E
E
-
H
Q
F
A
L
Q
L
V
N
-----
D
E
V
P
V
A
-------------
A
P
V
A
F
N
GQT
L
L
N
-
H
----------
Q
G
F
Y
F
A
V
F
P
S
V
G
G
-
R
Q
F
----------------------
E
A
D
N
I
D
Q
M
E
A
V
G
R
Y
L
G
R
-
M
H
----
Q
T
G
-
R
K
Q
----
L
----
F
I
H
R
P
T
I
G
-
L
N
-
E
Y
--
L
I
E
P
R
K
L
-
F
E
D
--
A
T
L
-
I
P
S
--
G
--
L
K
A
A
F
--
L
K
A
T
D
E
--
L
I
A
A
V
T
A
H
W
------
R
-
E
---
D
--
F
---
T
V
----
L
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
---
G
-
P
---
M
F
V
D
L
DDA
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
E
Q
R
M
Q
L
E
T
-------------
I
I
E
-----
A
Y
--
E
--
E
F
S
E
FD
T
A
E
I
G
L
-
I
E
P
L
R
A
M
--
R
L
--
V
Y
----
Y
-----
L
A
W
L
M
R
R
W
---------
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
-
I
E
Q
A
K
V
L
Q
--------
E
P
P
L
--
Q
L
T
P
M
Y
------------------
78
HHSearch
67.67
12%
-57
- C2 -
-
3HAM
3
?
A:
[1-273]
-----------------
M
V
N
L
D
A
E
I
Y
E
H
L
N
K
-
Q
I
K
----
I
---
N
E
L
R
Y
L
S
----
S
G
D
---
D
S
D
T
F
L
C
--
N
----
E
----
Q
---------
Y
--
V
-
V
K
V
P
K
R
-
D
S
-
V
-
R
I
S
-
Q
K
R
E
-
F
E
L
Y
R
F
L
E
N
-
C
-
K
-
L
S
Y
Q
I
P
-------------
A
V
V
Y
Q
--------------------
S
D
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
--
H
K
L--------
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
-
I
E
----
I
D
C
-
S
V
S
----
L
----
F
---
S
D
A
L
-
V
N
-
K
K
--
D
K
F
L
Q
D
K
--
K
L
-
L
I
S
I
-
L
E
K
--
E
----
Q
L
L
--
T
D
E
M
L
E
--
H
I
E
T
I
Y
E
N
I
------
L
N
N
AV-
L
--
F
-
K
Y
T
P
----
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
---
N
-----
R
L
F
G
V
--------
I
D
F
G
D
-
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
-------------
C
S
T
D----
D
F
--
G
--
K
E
F
G
--
R
K
V
L
K
Y
-
Y
Q
-
H
K
A
P
--
E
V
--
A
-----------
E
R
K
A
E
L
N
D
---------
V
Y
W
S
I
D
Q
I
-
I
Y
G
------------------------------------------------------------
72
HHSearch
67.25
13%
-30
- C2 -
-
5IQC
2
AACA_STAAU
A:
[17-284]
-----------------------
Y
L
I
E
H
Y
F
D
-
N
F
K
----
V
---
D
S
I
E
I
I
G
----
S
G
Y
---
D
S
V
A
Y
L
V
--
N
----
N
----
E
---------
Y
--
I
-
F
K
T
K
F
S
-
T
N
-
K
-
K
K
G
-
Y
A
K
E
-
K
A
I
Y
N
F
L
N
T
-
N
-
L
E
T
N
V
K
I
P
-------------
N
I
E
Y
S
Y
-----
I
-
S
----------
D
E
L
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
E
I
Y
--
S
T
M--------
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
-
L
D
----
Y
T
D
-
I
S
E
----
C
----
T
-
I
-------
D
-
N
K
--
Q
N
V
L
E
E
Y
-
I
-
L
-
L
R
E
T
-
I
Y
N
--
D
--
L
T
D
-
I
-----
E
K
D
--
Y
I
E
S
F
M
E
R
L
------
N
-
A
TT-
V
--
F
-
E
G
K
K
----
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
-
N
---
R
L
T
G
I
--------
I
D
F
G
D
-
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
-------------
D
S
E
E----
E
I
--
G
--
T
N
F
G
--
E
D
I
L
R
M
-
Y
G
-
N
I
----
D
I
--
E
K
----
A
-----
K
E
Y
Q
D
I
V
E
---------
E
Y
Y
P
I
E
T
I
-
V
Y
G
I
K
----------------------------------------------------------
68
HHSearch
66.23
14%
-30
- C2 -
-
5IQI
1
AACA_STAAU
C:
[17-284]
-----------------------
Y
L
I
E
H
Y
F
D
-
N
F
K
----
V
---
D
S
I
E
I
I
G
----
S
G
Y
---
D
S
V
A
Y
L
V
--
N
----
N
----
E
---------
Y
--
I
-
F
K
T
K
F
S
-
T
N
-
K
-
K
K
G
-
F
A
K
E
-
K
A
I
Y
N
F
L
N
T
-
N
-
L
E
T
N
V
K
I
P
-------------
N
I
E
Y
S
Y
-----
I
-
S
----------
D
E
L
S
I
L
G
Y
K
E
I
K
G
-
T
F
L
T
P
E
I
Y
--
S
T
M--------
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
-
L
D
----
Y
T
D
-
I
S
E
----
C
----
T
-
I
-------
D
-
N
K
--
Q
N
V
L
E
E
Y
-
I
L
L
-
R
E
-
T
-
I
Y
N
--
D
--
L
T
D
-
I
-----
E
K
D
--
Y
I
E
S
F
M
E
R
L
------
N
-
A
TT-
V
--
F
-
E
G
K
K
----
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
-
N
---
R
L
T
G
I
--------
I
D
F
G
D
-
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
-------------
D
S
E
E----
E
I
--
G
--
T
N
F
G
--
E
D
I
L
R
M
-
Y
G
-
N
I
----
D
I
--
E
K
----
A
-----
K
E
Y
Q
D
I
V
E
---------
E
Y
Y
P
I
E
T
I
-
V
Y
G
I
K
----------------------------------------------------------
99
Fugue
60.54
11%
-82
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-----------------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
-
K
Y
R
----
C
---
V
K
D
T
E
G
M
----
S
P
A
---
K
V
Y
K
L
V
G
--
E
----
N
----
E
---------
N
--
L
-
Y
L
K
M
T
D
-
S
R
-
Y
-
K
G
T
-
T
Y
D
V
-
E
R
E
K
D
M
M
L
W
-
L
-
E
-
G
K
L
P
V
P
-------------
K
V
L
H
F
E
-----
R
-
H
----------
D
G
W
S
N
L
L
M
S
E
A
D
G
-
V
L
C
S
E
E
Y
---
E
----------
D
E
Q
-
S
P
E
K
I
I
E
L
Y
A
E
C
I
R
L
F
H
--
S
----
I
D
I
-
S
D
C
----
P
----
Y
T
N
S
L
D
S
R
-
L
A
-
E
L
--
D
Y
L
L
N
N
D
-
L
A
D
-
V
D
C
E
-
N
W
E
--
E
--
D
T
P
F
K
--
D
P
R
E
L
Y
--
D
F
L
K
T
E
K
P
E
------
E
------------
E
L
----
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
----
D
-
G
---
K
V
S
G
F
--------
I
D
L
G
-
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
-------------
S
I
R
-----
E
D
--
I
--
G
E
E
-------
Q
Y
-
V
E
L
F
F
D
L
--
L
G
--
I
K
----
P
D----
W
E
K
I
K
Y
Y
I
---------
L
L
D
E
L
F
------------------------------------------------------------------
82
HHSearch
60.46
12%
-58
- C2 -
-
4DCA
1
?
A:
[26-294]
---------------------
D
A
E
I
Y
E
H
L
N
K
-
Q
I
K
----
I
---
N
E
L
R
Y
L
S
----
S
G
D
---
D
S
D
T
F
L
C
--
N
----
E
----
Q
---------
Y
--
V
-
V
K
V
P
K
R
-
D
S
-
V
-
R
I
S
-
Q
K
R
E
-
L
E
L
Y
R
F
L
E
N
-
C
-
K
-
L
S
Y
Q
I
P
-------------
A
V
V
Y
Q
--------------------
S
D
R
F
N
I
M
K
Y
I
K
G
-
E
R
I
T
Y
E
Q
Y
--
H
K
L--------
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
-
I
E
----
I
D
C
-
S
V
S
----
L
----
F
---
S
D
A
L
-
V
N
-
K
K
--
D
K
F
L
Q
D
K
--
K
L
-
L
I
S
I
-
L
E
K
--
E
----
Q
L
L
--
T
D
E
M
L
E
--
H
I
E
T
I
Y
E
N
I
------
L
-
S
NAV
L
--
F
-
K
Y
T
P
----
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
---
N
-----
R
L
F
G
V
--------
I
D
F
G
D
-
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
-------------
C
S
T
D----
D
F
--
G
--
K
E
F
G
--
R
K
V
L
K
Y
-
Y
Q
-
H
K
A
P
--
E
V
--
A
-----------
E
R
K
A
E
L
N
D
---------
V
Y
W
S
I
D
Q
I
-
I
Y
G
------------------------------------------------------------
111
Fugue
60.26
14%
-21
- C2 -
-
3CSV
11
?
A:
[4-333]
-------------------
S
R
E
D
E
I
R
D
F
L
A
T
-
H
-
G
----
Y
---
A
D
W
N
R
T
P
----
R
Y
Q
---
R
L
R
S
P
T
G
--
A
----
K
----
A
---------
V
--
L
M
D
W
S
P
E
E
-
G
G
-
D
-
T
Q
P
-
F
V
D
L
-
A
Q
Y
L
R
N
--------
L
D
I
S
A
P
-------------
E
I
Y
A
E
E
-----
H
-
A
----------
R
G
---------------------------------
L
L
L
-
I
E
D
L
G
D
A
L
F
T
E
V
I
N
N
D
P
-
A
Q
E
M
P
L
Y
R
A
-
A
V
D
----
L
----
L
I
H
L
H
D
A
Q
-
T
P
-
E
L
--
A
R
L
D
P
E
T
-
L
S
E
M
T
R
L
A
-
F
S
E
--
Y
--
R
Y
A
I
L
--
G
D
A
A
E
D
--
N
R
K
R
F
E
H
R
F
------
A
-
Q
---
I
--
L
-
S
A
Q
L
EGDM
V
F
V
H
R
D
F
H
A
Q
N
L
L
W
L
P
---
E
-
R
EGL
A
R
V
G
V
--------
I
D
F
Q
D
-
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
-------------
D
A
R
-----
R
D
--
V
--
P
A
Q
V
--
E
A
---
Q
M
I
D
H
Y
I
Q
A
--
T
G
--
V
D
----
E
-----
S
H
F
R
S
A
Y
A
V
I
A
V
Q
R
N
M
R
I
L
G
I
F
A
R
L
-
S
Q
R
F
G
K
R
H
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
A
--------
H
P
A
L
--
A
S
A
A
E
E
I
L
N
A
L
PAPA
P
E
V
L
E
R
L
R
A
107
Fugue
59.68
13%
22
- C2 -
-
3JR1
3
?
A:
[14-309]
----------N
L
Y
F
Q
G
M
W
K
S
I
S
Q
V
L
A
E
Q
F
G
A
-
Y
Y
F
----
I
---
K
H
K
E
K
L
Y
----
S
G
E
M--
N
E
I
W
L
I
N
--
D
----
E
----
V
---------
Q
--
T
-
V
F
V
K
I
N
-
E
R
-
S
-
Y
R
S
M
F
R
A
E
-
A
D
Q
L
A
L
L
A
K
-
T
-
N
-
S
-
I
N
V
P
-------------
L
V
Y
G
I
G
-----
N
-
S
----------
Q
G
H
S
F
L
L
L
E
A
L
N
K
-
S
K
N
K
Q
S
S
---
F
----------
T
I
F
-
A
E
K
I
A
Q
L
H
Q
I
Q
G
P
D
K
Y
G
-
L
D
----
F
D
T
-
W
L
G
----
P
----
I
Y
Q
-
P
N
D
W
-
Q
T
-
S
W
--
A
K
F
F
S
E
N
R
I
G
W
-
Q
L
Q
I
-
C
K
E
--
K
----
G
L
I
--
F
G
N
I
D
L
--
I
V
Q
I
V
A
D
T
L
------
S
-----
K
--
H
-
N
P
K
P
----
S
I
L
H
G
N
L
W
I
E
N
C
I
Q
V
D
---
D
-
K
---
I
F
V
------------
C
N
P
A
C
Y
W
G
D
R
E
C
D
I
A
F
S
-----------------
S
-----
L
F
--
E
--
P
F
P
T
--
N
F
Y
Q
R
Y
-
N
E
I
Y
P
L
E
--
E
G
--
Y
L
----
E
-----
R
K
L
I
Y
Q
L
Y
---------
Y
L
L
N
F
S
Y
R
-
Y
Y
--------
N
K
K
Q
S
Y
-
V
S
L
T
Q
K
L
I
--------
N
Q
I
L
--
H
K
----------------------
74
HHSearch
59.17
13%
-6
- C2 -
-
5IWU
2
?
A:
[21-298]
---------------------------------------
E
---
E
T
I
Q
F
N
E
----
S
G
L
---
D
F
Q
A
V
F
A
--
Q
----
D
NNG
I
D
---------
W
--
V
-
L
R
L
P
R
R
-
E
D
-
V
-
M
P
R
-
T
K
V
E
-
K
Q
A
L
D
L
V
N
K
-
Y
-
A
-
I
S
F
Q
A
P
-------------
N
W
I
I
Y
--------------------
T
E
E
L
I
A
Y
K
K
L
D
G
-
V
P
A
G
T
I
D
---
H
NIGNYIWEID
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
-
I
P
----
S
N
K
-
A
A
A
----
L
----
D
L
V
V
H
T
---
P
E
-
E
A
--
R
M
S
M
K
Q
R
-
M
D
A
-
V
-----
R
A
--
K
--
F
G
--
V
--
G
---
E
N
--
L
W
N
R
W
Q
A
W
L
------
N
-
D
D--
D
M-
W
-
P
K
K
T
----
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
---
D
-
A
---
N
V
T
G
L
--------
I
D
W
T
E
-
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
-------------
A
F
----------
G
--
E
E
G
L
--
E
A
L
I
L
A
-
Y
K
-
E
I
G
G
--
Y
Y
W-
P
K
----
M
-----
K
E
H
I
I
E
L
N
---------
A
A
Y
P
V
S
I
A
-
E
F
A
L
V
----
S
G
I
E
E
Y
E
-
Q
M
A
K
E
A
L
E
--------------------------------------
67
HHSearch
58.07
11%
-40
* C2 *
-
3TDW
1
?
A:
[9-292]
----------------------
T
T
M
I
M
T
Q
F
P
-
D
I
S
----
I
---
Q
S
V
E
S
L
G
----
E
G
F
---
R
N
Y
A
I
L
V
--
N
----
G
----
D
---------
W
--
V
-
F
R
F
P
K
S
-
Q
Q
-
G
-
A
D
E
-
L
N
K
E
-
I
Q
L
L
P
L
L
V
G
-
C
---
V
K
V
N
I
P
-------------
Q
Y
V
Y
I
G
-----
K
R
S
----------
D
G
N
P
F
V
G
Y
R
K
V
Q
G
-
Q
I
L
G
E
D
G
M
A
V
L
----------
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
-
F
P
----
V
E
T
-
A
I
S
----
A
----
G
V
--
P
----
V
T
-
N
L
--
K
N
K
I
L
L
L
-
S
E
A
-
V
E
D
Q
-
V
F
P
--
L
--
L
D
E
S
L
--
R
---
D
Y
--
L
T
L
R
F
Q
S
Y
M
------
T
-
H
PV-
Y
--
T
-
R
Y
T
P
----
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
NSR
Q
-
T
---
P
L
T
G
I
--------
I
D
F
G
D
-
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
-------------
D
C
G
------------
E
L
F
T
---
R
Q
V
M
A
-
Y
R
-
G
E
V
D
--
L
D
---
T
----
H
-----
I
R
K
V
S
L
F
V
---------
T
F
D
Q
V
S
Y
L
-
L
E
G
L
R
----
A
R
D
Q
D
W
I
-
S
E
G
L
E
L
----------------------------------------
112
Fugue
57.53
14%
-1
- C2 -
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
------------------
T
D
I
T
E
D
E
L
R
N
F
L
T
-
Q
Y
D
----
V
---
G
S
L
T
S
Y
K
----
G
I
A
---
E
N
S
N
F
L
L
--
H
T
T
K
-
D
----
P
---------
L
--
I
-
L
T
L
Y
E
K
-
K
N
-
D
-
L
P
F
-
F
L
G
L
M
Q
H
L
A
A
K
G
L
S
-
C
-
P
-
L
P
L
P
R
K
-------------
D
G
E
L
L
G
-----
E
-
L
----------
S
G
R
P
A
A
L
I
S
F
L
E
G
M
W
L
R
K
P
E
-----------------------
A
K
H
C
R
E
V
G
K
A
L
A
A
M
H
L
----
A
S
E
-
G
F
E
----
I
----
K
R
--
P
N
A
L
-
S
V
-
D
G
--
W
K
V
L
W
D
K
-
S
E
E
-
R
A
D
E
-
V
E
K
--
G
--
L
R
E
E
I
--
R
P
E
I
D
Y
--
L
A
A
H
W
P
K
D
L
------
P
-
A
---
G
-------------
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
----
G
-
D
---
E
L
S
G
L
--------
I
D
F
Y
-
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
-------------
A
W
C
-----
F
---
E
--
K
D
G
A
--
Y
N
V
T
K
G
-
K
A
L
L
E
G
Y
--
Q
S
--
V
R
----
P
L
S
E
A
E
L
E
A
L
P
L
L
S
---------
R
G
S
A
L
R
F
F
-
L
T
R
L
Y
D
W
L
T
T
P
A
G
A
L
V
-
V
K
K
D
P
L
E
Y
--------
L
R
K
L
--
R
F
H
R
T
I
A
N
V
AEYGLA---------
73
HHSearch
57.53
13%
-6
- C2 -
-
5UXA
-
?
A:
[21-298]
---------------------------------------
E
---
E
T
I
Q
F
N
E
----
S
G
L
---
D
F
Q
A
V
F
A
--
Q
----
D
NNG
I
D
---------
W
--
V
-
L
R
L
P
R
R
-
E
D
-
V
-
M
P
R
-
T
K
V
E
-
K
Q
A
L
D
L
V
N
K
-
Y
-
A
-
I
S
F
Q
A
P
-------------
N
W
I
I
Y
--------------------
T
E
E
L
I
A
Y
K
K
L
D
G
-
V
P
A
G
T
I
D
---
H
NIGNYIWEID
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
-
I
P
----
S
N
K
-
A
A
A
----
L
----
D
L
V
V
H
T
---
P
E
-
E
A
--
R
M
S
M
K
Q
R
-
M
D
A
-
V
-----
R
A
--
K
--
F
G
--
V
--
G
---
E
N
--
L
W
N
R
W
Q
A
W
L
------
N
-
D
D--
D
M-
W
-
P
K
K
T
----
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
---
D
-
A
---
N
V
T
G
L
--------
I
D
W
T
E
-
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
-------------
A
F
----------
G
--
E
E
G
L
--
E
A
L
I
L
A
-
Y
K
-
E
I
G
G
--
Y
Y
W-
P
K
----
M
-----
K
E
H
I
I
E
L
N
---------
A
A
Y
P
V
S
I
A
-
E
F
A
L
V
----
S
G
I
E
E
Y
E
-
Q
M
A
K
E
A
L
E
--------------------------------------
88
SP3
56.95
14%
-16
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-------------------
G
S
P
A
A
W
V
E
R
L
F
----
G
----
Y
D
--
W
A
Q
Q
T
-
I
----
G
C
S
---
D
A
A
V
F
R
L
--
S
----
A
----
Q
---------
G
R
P
V
-
L
F
V
K
T
D
L
S
G
-
A
-
L
N
E
-
L
Q
D
E
-
A
A
R
L
S
W
L
A
T
-----
T
G
V
P
C
A
-------------
A
V
L
D
V
V
-----
T
-
E
----------
A
G
R
D
W
L
L
L
G
E
V
P
G
-
Q
D
L
L
S
S
---------------
H
L
A
-
P
A
E
K
V
S
I
M
A
D
A
M
R
R
L
H
T
-
L
D
----
P
A
T
C
P
F
D
----
H
----
Q
------------------
A
K
H
R
-
I
E
R
-
A
R
T
R
-
M
E
A
G-
L
--
V
D
Q
D
D
--
L
D
E
E
H
Q
GL
A
P
A
E
L
F
A
R
L
------
K
-
A
R
M-
P
--
D
-
G
E
D
L
----
V
V
T
H
G
D
A
C
L
P
N
I
M
V
-
E
---
N
-
G
---
R
F
S
G
F
--------
I
D
C
G
-
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
-------------
D
I
A
-----
E
E
--
L
--
G
--------
G
E
W
-
A
D
R
F
L
V
L
--
Y
G
IA
A
P
----
D
-----
S
Q
R
I
A
F
Y
R
---------
L
L
D
E
F
F
------------------------------------------------------------------
106
Fugue
56.09
12%
21
- C2 -
-
3I1A
2
?
A:
[3-330]
------------KQPIQ
A
Q
Q
L
I
E
L
L
K
V
H
Y
G
I
-
D
I
H
----
T
---
A
Q
F
I
Q
G
G
----
A
D
T
---
N
A
F
A
Y
Q
A
D
S
E
----
S
----
K
---------
S
--
Y
-
F
I
K
L
K
Y
-
G
Y
-
H
-
D
E
I
-
N
L
S
I
-
I
R
L
L
H
D
S
G
I
-
K
-
E
-
I
I
F
P
I
H
TLEAKL
F
Q
Q
L
KH
F
K
I
I
A
Y
P
-----
F
-
I
----------
H
A
P
N
G
F
T
Q
N
-
L
T
G
-
K
Q
W
K
Q
L
G
---
K
----------
V
L
R
-
Q
I
H
E
T
S
V
P
I
S
I
Q
Q
Q
L
R
K
-
E
I
----
Y
S
P
-
K
W
R
----
E
----
I
V
R
S
F
Y
N
Q
-
I
E
-----
F
D
N
S
D
D
K
-
L
T
A
-
A
F
K
S
-
F
F
N
--
Q
--
N
S
A
A
I
--
H
R
L
V
D
T
--
S
E
K
L
S
K
K
I
---------
Q
---
P
--
D
-
L
D
K
Y
----
V
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
---
E
-
E
---
S
-
I
Y
I
--------
I
D
W
D
E
-
P
M
L
A
P
K
E
R
D
L
------------------
M
F
I
-----
G
G
--
G
--
V
G
N
V
--
W
N
K
P
H
E
-
I
Q
Y
F
Y
E
G
Y
G
E
I
--
N
V
----
D
-----
K
T
I
L
S
Y
Y
R
---------
H
E
R
I
V
E
D
I
-
A
V
Y
G
Q
D
L
L
S
R
N
Q
N
N
Q
S
-
R
L
E
S
F
K
Y
F
--------
K
E
M
F
DP
N
N
V
V
E
I
A
F
A
T
E-------------
6
PsiBlast_PDB
55.85
20%
27
- C2 -
-
5IQA
1
AACA_STAAU
A:
[36-257]
------------------------------------------------------
S
G
Y
---
D
S
V
A
Y
L
V
--
N
----
N
----
E
---------
Y
--
I
-
F
K
T
K
F
S
-
T
N
-
K
-
K
K
G
-
Y
A
K
E
-
K
A
I
Y
N
F
L
N
T
-
N
L
E
-
T
N
V
K
I
P
-------------
N
I
E
Y
S
Y
-----
I
-----------------
S
D
E
L
S
I
L
G
-
Y
K
-
E
I
K
G
---
T
----------
F
L
T
-
P
------------
E
I
Y
S
-
T
M
----
S
E
E
-
E
Q
N
L
L
K
R
D
----
I
A
S
F
L
R
Q
M
-
H
G
L
D
Y
--
T
D
I
S
E
C
T
-
I
D
N
-
K
Q
N
V
-
L
E
E
Y
I
L
--
L
R
E
T
I
--
Y
N
D
L
T
D
--
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
-
T
---
V
--
F
-
E
G
K
K
----
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
-
N
---
R
L
T
G
I
--------
I
D
------
F
G
D
S
G
I
-
I
D
E
Y
C
D
-------------
F
I
Y
-----
L
L
--
E
--
D
S
E
E
--
E
I
G
T
N
F
-
G
E
D
I
L
R
M
--
Y
G
--
N
----------------------------------------------------------------------------------------------------
77
HHSearch
54.99
14%
-9
- C2 -
-
6EF6
2
?
A:
[29-320]
-----------------------
T
I
A
Q
Q
A
L
T
-
H
Y
D
----
V
SDN
A
S
L
R
L
L
-----
N
L
S
---
E
N
A
T
Y
L
V
--
E
----
D
GE
H
-
Q
---------
S
--
I
-
L
R
V
H
R
Q
-
D
Y
-
H
Q
P
H
E
-
I
E
S
E
-
L
D
W
L
A
A
L
R
T
D
S
----
D
V
T
V
P
-------------
T
V
V
P
A
R
-----
D
-
G
RR
V
V
T
V
D
P
A
D
V
P
R
H
V
V
H
F
E
M
V
G
G
-
A
E
P
D
E
E
S
---
L
--------------
T
L
D
D
F
Q
T
L
G
R
I
T
A
S
L
H
E
-
H
S
----
Q
R
W
-
T
R
P
---------
A
G
F
G
-----
R
F
-
S
W
DW
E
H
C
L
G
D
--
T
P
R
-
W
G
-
R
-
W
Q
D
--
A
EG
V
G
A
S
E
--
T
A
L
L
T
R
--
A
Q
D
L
L
H
R
K
L
------
E
-
E
---
Y
GS
G
-
P
D
R
Y
----
G
L
I
H
A
D
L
R
L
A
N
L
L
V
D
S
---
S
-
T
PQ-
R
T
I
T
V
--------
I
D
F
D
D
-
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
-------------
F
I
E
-----
H
D
PR
L
--
G
E
W
Q
--
E
S
W
V
A
G
-
Y
R
-
S
R
R
E
--
L
P
--
A
A
----
D
-----
E
A
M
L
P
S
F
V
---------
F
L
R
R
L
L
L
L
-
A
W
M
G
S
----------------------------------------------------------