@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q5QYF2_IDILO: (2019-02-01 )
MIGRPCEIQLLASGQSNQTLRLRTDTEDYVLKRWRYEQVFAVDRELEVSIQKELAQQALAPEVLAYDAKQGWFLQPYYQAPSLQQVTLSPLIKATVLAETLSKIHNTRVDIPAWSMSERVEHYLQQLRSVNSAVAAQMSQKLVPMQPLLEDWLSYPVLCHNDLSMNHILMADPIRIIDWEYAGIGHPLFDIASAIVVNELSDQASVRLITEYEKIAHYQIDRQRLAQWCEFVEWLNKVWQHLFRHLS
Atome Classification :
(20 SA)
---------------------------------------.........10......-..20..--------..---------.----------.-..30......-..40.........50......-..---60........-----70--........-80-.---......------------.90.-.......100.......110-.-.---.---------------.-----....120.......---------------130---.-------.--------.---------------..----....140-----........--150-..--.......160.......170--.--------.--.-..--...180.......190......---------.---200----------------.------------------........210---------...--.-----.-------------.----------.220.......230----........240.....-------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---------------------------------------MIGR
P
C
E
I
Q
L
L
ASGQSN-
Q
T
L
R
L
R--------TD---------
T
----------
E
-
D
Y
V
L
K
R
W
R
Y
E
-
Q
V
F-AVD
R
E
L
E
V
S
I
Q
K
E
L
A
Q
Q
-AL---A
P
E
V
L
A
YDAK-----QG--
W
F
L
Q
P
YYQ-AP-S---
L
Q
Q
V
T
L
------------
S
P
L
I
-
K
A
T
V
L
A
E
T
L
S
K
I
HNTRVDI--P-A---W---------------
S
-----
M
S
E
R
V
E
H
Y
L
Q
Q
L
R
S
---------------
V
-----
N
-------
S
--------
A
---------------
V
A
----
A
Q
M
S
QK------LV
P
M
Q
P
L
L
--
E
---
D
W
--LSY
P
V
L
CHNDLSMN
H
I
L
MA---D--------
P
--
I
-
R
I
--
I
D
W
E
YAGIG
H
P
L
F
D
I
A
S
A
I
V
V
N
---------E---L------------------S------------------DQA
S
V
R
L
I
T
E
Y
---------
E
K
I
--
A
-----
H
-------------
Y
----------
Q
I
D
R
Q
R
L
A
Q
W
C
E
F
-----
V
E
W
L
N
K
V
W
Q
H
L
F
R
HLS-------------------------------------------------
121
HHSearch
82.02
20%
-8
- C2 -
-
1NW1
-
CKA2_CAEEL
B:
[74-397]
------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
N
-
M
L
F
L
C
R
--------
L
S
EVYPPIRNE
P
----------
N
-
K
V
L
L
R
V
Y
F
N
P
-
E
-
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
---
G
P
K
L
Y
G
I
F
S
G
---------
G
R
L
E
E
Y
I
P
-
S
R
-
P
---
L
S
C
H
E
I
-------------
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
I
--
W
-
K
EP-
D
---------------
Y
-----
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
---------------
T
V
----
D
AE
H
R
F
D
L
P
--------
E
ECGVSSV--------
N
C
----
L
D
L
A
R
E
------
L
E
F
L
R
A
H
I
--
S
---
L
S
--
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
--------
R
--
L
-
V
L
--
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
---------
T
---
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
---------
L
R
E
Q
-
G
-----
N
TRENE
L
Y
K
K
----
S
----------
E
D
L
V
Q
E
T
L
P
F
V
P
V
-----
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
--------------------------------------------------
120
HHSearch
81.85
20%
-6
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[74-397]
------------------------------------------
E
H
L
R
I
S
R
I
K
G
G
M
S
N
-
M
L
F
L
C
R
--------
L
S
EVYPPIRNE
P
----------
N
-
K
V
L
L
R
V
Y
F
N
P
-
E
-
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
---
G
P
K
L
Y
G
I
F
S
G
---------
G
R
L
E
E
Y
I
P
-
S
R
-
P
---
L
S
C
H
E
I
-------------
S
L
A
H
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
I
--
W
-
K
EP-
D
---------------
Y
-----
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
---------------
T
V
----
D
AE
H
R
F
D
L
P
--------
E
ECGVSSV--------
N
C
----
L
D
L
A
R
E
------
L
E
F
L
R
A
H
I
--
S
---
L
S
--
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
--------
R
--
L
-
V
L
--
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
---------
T
---
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
---------
L
R
E
Q
-
G
-----
N
TRENE
L
Y
K
K
----
S
----------
E
D
L
V
Q
E
T
L
P
F
V
P
V
-----
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
--------------------------------------------------
106
SP3
80.54
20%
-27
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWKT
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
-
M
L
F
L
C
R
--------
L
S
---------
E
VYPPIRNEP-
N
-
K
V
L
L
R
V
Y
F
-
N
-
P
E
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
---
G
P
K
L
Y
G
I
F
-------
S
G
--
G
R
L
E
E
Y
I
P
-
S
R
-
P
---
L
S
C
H
E
I
------------
S
L
A
H
-
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
I
--
W
-
K
EP-
D
---------------
Y
-----
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
---------------
T
-----
V
-------
D
--------
A
E
H
R
F
D
L
PEECGVSSV
N
C
----
L
D
L
A
R
E
------
L
E
F
L
R
A
H
I
--
S
---
L
S
--
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
--------
R
--
L
-
V
L
--
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
---------
T
---
I
DYDIDEAPF
Y
K
I
Q
TENFP
E
------------------
N
D
Q
M
L
E
F
F
L
N
Y
---------
L
R
E
--
Q
-----
G
-------------
N
TRENE
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
-----
S
H
F
F
W
G
V
W
G
L
L
Q
V
E
L
S
PVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA---------------------
129
HHSearch
73.96
19%
-10
- C2 -
-
5FUT
9
CHKA_HUMAN
A:
[30-350]
------------------------------------------
D
E
F
H
I
S
V
I
R
G
G
L
S
N
-
M
L
F
Q
C
S
--------
L
P
---------
D
TTATLGDEP-
R
-
K
V
L
L
R
L
Y
G
------G
A
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
---
G
P
K
L
Y
G
I
F
P
Q
---------
G
R
L
E
Q
F
I
P
-
S
R
-
R
---
L
D
T
E
E
L
-------------
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
F
--
N
-
K
---
E
PK-------------
W
-----
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
---------------
I
KFT--
E
E
S
R
I
---
K
--------
K
---------------
L
H
K
L
L
S
Y
N
L
P
L
E
------
L
E
N
L
R
S
L
L
--
E
---
S
T
--
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
GRENSEKQ
K
--
L
-
M
L
--
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
---------
M
---
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
---------
L
P
A
F
-
Q
-----
N
DFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
-----
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
---------------------------------------------------
117
HHSearch
72.11
18%
1
- C2 -
-
4R78
2
?
A:
[38-280]
------------------------------------------
E
V
L
S
V
E
Q
L
-
G
G
M
T
N
-
Q
N
Y
L
A
K
--------
T
T
---------
N
----------
K
-
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
---
D
V
K
N
Y
L
F
D
I
E
-----
A
G
--
I
K
V
N
E
Y
I
E
-
S
A
I
T
---
L
D
S
T
---------------
S
I
K
T
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
--
R
-
G
E
--
F
---------------
A
-----
P
F
E
E
I
K
K
Y
E
S
L
I
E
E
---------------
Q
I----
P
-------
Y
--------
A
---------------
N
Y
----
E
S
V
R
N
A
------
V
F
S
L
E
K
R
L
--
A
---
D
L
--
G
V
D
R
K
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C
H
I
D
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V
P
E
N
F
I
E
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---
P
Q
G
------
R
--
L
-
Y
L
--
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
---------
E
---
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
---------
E
S
D
--------
Q
-------------
T
----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
-----
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
---------------------------------------------------
116
HHSearch
71.82
18%
2
- C2 -
-
4R7B
-
?
A:
[38-280]
------------------------------------------
E
V
L
S
V
E
Q
L
-
G
G
M
T
N
-
Q
N
Y
L
A
K
--------
T
T
---------
N
----------
K
-
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
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N
L
E
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L
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D
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-
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---
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F
D
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A
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--
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S
A
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---
L
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---------------
S
I
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--
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-
G
E--
F
---------------
A
-----
P
F
E
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I
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K
Y
E
S
L
I
E
E
---------------
Q
I----
P
-------
Y
--------
A
---------------
N
Y
----
E
S
V
R
N
A
------
V
F
S
L
E
K
R
L
--
A
---
D
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--
G
V
D
R
K
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C
H
I
D
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P
E
N
F
I
E
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---
P
QG------
R
--
L
-
Y
L
--
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
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---------
E
---
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
---------
E
S
D
--------
Q
-------------
T
----------
P
V
S
H
E
K
I
A
I
Y
K
I
L
-----
Q
D
T
I
W
S
L
W
T
V
Y
K
E
E
---------------------------------------------------
123
HHSearch
70.90
19%
-26
- C2 -
-
3DXQ
-
?
B:
[24-262]
------------------------------------------------
E
R
L
G
G
L
T
N
-
L
V
F
R
A
-------------------------------
G
-
D
L
C
L
R
I
P
----------
N
R
A
N
E
A
V
A
A
R
E
A
A
K
A
-
G
V
---
S
P
E
V
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H
V
D
P
A
-----
T
G
--
V
M
V
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R
Y
I
A
-
G
A
Q
T
---
M
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P
E
K
F
------------
K
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R
P
G
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P
A
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A
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K
L
H
G
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G
A
V
F
--
P
F
R
---
F
---------------
E
-----
L
F
A
M
I
D
D
Y
L
K
V
L
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---------------
K
N
V
T
--
L
-------
P
--------
A
---------------
G
Y
----
H
D
V
V
R
E
------
A
G
G
V
R
S
A
L
--
A
---
A
H
--
P
L
P
L
A
A
C
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C
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L
C
E
N
F
L
D
T
---
G
E-------
R
--
M
-
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I
--
V
D
W
E
Y
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G
M
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P
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W
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---------
K
---
F
------------------
N
------------------
A
N
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E
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M
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A
Y
---------
F
G
G
--
E
-----
A
-------------
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----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
-----
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
---------------------------------------------------
128
HHSearch
70.76
19%
-3
- C2 -
-
5FTG
10
CHKA_HUMAN
A:
[30-350]
------------------------------------------
D
E
F
H
I
S
V
I
R
G
G
L
S
N
-
M
L
F
Q
C
S
--------
L
P
---------
D
TTATLGDEP-
R
-
K
V
L
L
R
L
Y
G
--------
E
A
M
V
L
E
S
V
M
F
A
I
L
A
E
R
-
S
L
---
G
P
K
L
Y
G
I
F
P
Q
---------
G
R
L
E
Q
F
I
P
-
S
R
-
R
---
L
D
T
E
E
L
-------------
S
L
P
D
I
S
A
E
I
A
E
K
M
A
T
F
H
G
M
K
M
P
F
--
N
-
K
---
E
PK-------------
W
-----
L
F
G
T
M
E
K
Y
L
K
E
V
L
R
---------------
I
KFT--
E
E
S
R
I
---
K
--------
K
---------------
L
H
K
L
L
S
Y
N
L
P
L
E
------
L
E
N
L
R
S
L
L
--
E
---
S
T
--
P
S
P
V
V
F
C
H
N
D
C
Q
E
G
N
I
L
L
L
---
E
GRENSEKQ
K
--
L
-
M
L
--
I
D
F
E
Y
S
S
Y
N
Y
R
G
F
D
I
G
N
H
F
C
E
W
---------
M
---
Y
------------------
D
YSYEKYPF
F
R
A
N
IRKYPT
K
K
Q
Q
L
H
F
I
S
S
Y
---------
L
P
A
F
-
Q
-----
N
DFENLS
T
E
E
K
S
I
I
K
----------
E
E
M
L
L
E
V
N
R
F
A
L
A
-----
S
H
F
L
W
G
L
W
S
I
V
Q
A
K
---------------------------------------------------
122
HHSearch
67.99
19%
-24
- C- -
-
3DXQ
-
?
A:
[24-262]
------------------------------------------------
E
R
L
G
G
L
T
N
-
L
V
F
R
A
-------------------------------
G
-
D
L
C
L
R
I
P
G
K
------
Y
I
N
R
A
N
E
A
V
A
A
R
E
A
A
K
A
-
G
V
---
S
P
E
V
L
H
V
D
P
A
-----
T
G
--
V
M
V
T
R
Y
I
A
-
G
A
Q
T
---
M
S
P
E
K
F
------------
K
T
R
P
G
S
P
A
R
A
G
E
A
F
R
K
L
H
G
S
G
A
V
F
--
P
F
R
---
F
---------------
E
-----
L
F
A
M
I
D
D
Y
L
K
V
L
S
-----------------NVT--
L
-------
P
--------
A
---------------
G
Y
----
H
D
V
V
R
E
------
A
G
G
V
R
S
A
L
--
A
---
A
H
--
P
L
P
L
A
A
C
H
C
D
P
L
C
E
N
F
L
D
T
---
G
E-------
R
--
M
-
W
I
--
V
D
W
E
Y
S
G
M
N
D
P
L
W
D
L
G
D
L
S
V
E
G
---------
K
---
F
------------------
N
------------------
A
N
Q
D
E
E
L
M
R
A
Y
---------
F
G
G
--
E
-----
A
-------------
R
----------
P
A
E
R
G
R
V
V
I
Y
K
A
M
-----
C
D
L
L
W
T
L
W
G
L
I
Q
L
A
---------------------------------------------------
91
Fugue
67.80
20%
10
- C2 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
LGGAWKT
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
S
N
-
M
L
F
L
C
R
L
S
EVYPPI
R
N
---------
E
----------
P
-
N
K
V
L
L
R
V
Y
F
N
-
P
E
T
-
E
S
H
L
V
A
E
S
V
I
F
T
L
L
S
E
R
-
H
L
---
G
P
K
L
Y
--
G
I
F
-----
S
G
--
G
R
L
E
E
Y
I
P
-
S
R
-
P
---
L
S
C
H
E
I
------------
S
L
A
H
-
M
S
T
K
I
A
K
R
V
A
K
V
H
Q
L
E
V
P
I
WK
E
-
P
---
D
---------------
Y
-----
L
C
E
A
L
Q
R
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
PEECG
V
-----
S
-------
S
--------
V
---------------
N
C
----
L
D
L
A
R
E
------
L
E
F
L
R
A
H
I
--
S
---
L
S
--
K
S
P
V
T
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
---
K
--------
R
--
L
-
V
L
--
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
---------
T
---
I
------------------
D
YD----------------
I
D
E
A
P
F
Y
K
I
Q
T
---------
E
N
F
--
P
-----
E
-------------
N
----------
D
Q
M
L
E
F
F
L
N
Y
L
R
E
Q
GNTR
E
N
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
PF
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
12
PsiBlast_PDB
65.31
21%
7
- C2 -
-
4R77
-
?
B:
[26-245]
---------------------------------------------------
G
G
M
T
N
-
Q
N
Y
L
A
K
--------
T
T
---------
N
----------
K
-
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
---
D
V
K
N
Y
L
F
D
I
E
-----
A
G
--
I
K
V
N
E
Y
I
E
S
A
I
-
T
---
L
D
S
T
S
I
------------
K
--
T
-
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
--
R
-
G
E--
F
---------------
A
-----
P
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q--------------
I
-----
P
-------
Y
--------
A
---------------
N
Y
----
E
S
V
R
N
A
------
V
F
S
L
E
K
R
L
--
A
---
D
L
--
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
---
P
--------
Q
--
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
---------
E
---
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
ESDQ
T
P
V
S
H
E
K
I
--
A
-----
I
-------------
Y
----------
K
I
---------------------------------------------------------------------------------
14
PsiBlast_PDB
65.17
21%
5
- C2 -
-
4R7B
-
?
A:
[46-265]
---------------------------------------------------
G
G
M
T
N
-
Q
N
Y
L
A
K
--------
T
T
---------
N
----------
K
-
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
---
D
V
K
N
Y
L
F
D
I
E
-----
A
G
--
I
K
V
N
E
Y
I
E
S
A
I
-
T
---
L
D
S
T
S
I
------------
K
--
T
-
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
--
R
-
G
E--
F
---------------
A
-----
P
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q--------------
I
-----
P
-------
Y
--------
A
---------------
N
Y
----
E
S
V
R
N
A
------
V
F
S
L
E
K
R
L
--
A
---
D
L
--
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
---
P
--------
Q
--
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
---------
E
---
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
ESDQ
T
P
V
S
H
E
K
I
--
A
-----
I
-------------
Y
----------
K
I
---------------------------------------------------------------------------------
138
HHSearch
65.03
18%
18
- C- -
-
3N4U
-
?
A:
[22-282]
-------------------------------------------
I
N
T
I
E
I
S
G
E
G
N
D
C
-
I
A
Y
E
I
--------------------
N
----------
R
-
D
F
I
F
K
F
P
K
H
S
-
R
-
G
-
S
T
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
L
P
L
P--
I
P
E
V
V
F
T
G
M
P
S
ETYQ
M
S
--
F
A
G
F
T
K
I
K
-
G
V
-
P
---
L
T
P
L
L
L
N
N
LP
K
-------
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
--
F
-
K
---
S
---------------
N
LVLD-
F
R
E
K
I
N
E
D
N
K
K
I
K
K
---------------
L
L
S
REL
K
-------
G
--------
P
---------------
Q
M
----
K
K
V
D
D
F
------
Y
R
D
I
L
E
N
E
--
I
---
Y
F
--
K
Y
Y
P
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
---
T
EKNT----
I
--
C
-
G
I
--
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
E
D
D
E--------
E
---
Y
------------------
G
------------------
M
E
F
V
S
K
I
L
N
H
Y
---------
K
H
K
--------
D
-------------
I
----------
P
T
V
L
E
K
Y
R
M
K
E
K
Y
-----
W
S
F
E
K
I
I
Y
G
K
E
Y
-----------------------------------------------------
13
PsiBlast_PDB
64.80
21%
1
- C2 -
-
4R78
2
?
A:
[46-265]
---------------------------------------------------
G
G
M
T
N
-
Q
N
Y
L
A
K
--------
T
T
---------
N
----------
K
-
Q
Y
I
V
K
F
F
G
K
G
-
T
E
K
-
L
I
N
R
Q
D
E
K
Y
N
L
E
L
L
K
D
L
-
G
L
---
D
V
K
N
Y
L
F
D
I
E
-----
A
G
--
I
K
V
N
E
Y
I
E
S
A
I
-
T
---
L
D
S
T
S
I
------------
K
--
T
-
K
F
D
K
I
A
P
I
L
Q
T
I
H
T
S
A
K
E
L
--
R
-
G
E
--
F
---------------
A
-----
P
F
E
E
I
K
K
Y
E
S
L
I
E
E
Q--------------
I
-----
P
-------
Y
--------
A
---------------
N
Y
----
E
S
V
R
N
A
------
V
F
S
L
E
K
R
L
--
A
---
D
L
--
G
V
D
R
K
S
C
H
I
D
L
V
P
E
N
F
I
E
S
---
P
--------
Q
--
G
-
R
L
Y
L
I
D
W
E
Y
S
S
M
N
D
P
M
W
D
L
A
A
L
F
L
E
S
---------
E
---
F
------------------
T
------------------
S
Q
E
E
E
T
F
L
S
H
Y
ESDQ
T
P
V
S
H
E
K
I
--
A
-----
I
-------------
Y
----------
K
I
---------------------------------------------------------------------------------
118
HHSearch
64.43
17%
5
- C2 -
-
2QG7
-
?
D:
[110-432]
-------------------------------------------
S
L
E
F
Q
I
I
N
G
G
-
T
N
-
I
L
I
K
V
K
--------
D
M
SK-------
Q
----------
A
-
K
Y
L
I
R
L
Y
G
P
K
-
T
D
----
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
---
A
K
K
I
Y
V
F
F
T
N
---------
G
R
I
E
E
F
M
D
-
G
Y
-
A
---
L
S
R
E
D
I
-------------
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
L
N
E
--
N
-
L
---
Y
KELQVTQKVPGTRPS
F
-----
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
---------------
E
R----
K
-------
K
ICSFDAKA
N
ILKLI----------
D
F
----
D
V
L
R
D
S
------
I
V
E
V
E
S
L
C
--
K
---
R
E
--
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VG--D-------
S
--
I
-
S
F
--
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
Y
AGFNCDWDL
T
---
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
---------
L
G
T
D-
D
EE---
L
-------------
I
----------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
-----
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
--------------------------------------------------
119
HHSearch
64.37
17%
13
- C2 -
-
2QG7
-
?
E:
[110-432]
-------------------------------------------
S
L
E
F
Q
I
I
N
G
-
I
T
N
-
I
L
I
K
V
K
--------
D
M
SK-------
Q
----------
A
-
K
Y
L
I
R
L
Y
G
P
K
-
T
D
E
-
I
I
N
R
E
R
E
K
K
I
S
C
I
L
Y
N
K
-
N
I
---
A
K
K
I
Y
V
F
F
T
N
---------
G
R
I
E
E
F
M
D
-
G
Y
-
A
---
L
S
R
E
D
I
-------------
K
N
P
K
F
Q
K
L
I
A
K
N
L
K
L
L
H
D
I
K
L
N
E
--
N
-
L
---
Y
KELQVTQKVPGTRPS
F
-----
L
W
N
T
I
W
K
Y
F
H
L
L
N
E
---------------
E
R----
K
-------
K
ICSFDAKA
N
ILKLI----------
D
F
----
D
V
L
R
D
S
------
I
V
E
V
E
S
L
C
--
K
---
R
E
--
N
S
P
I
V
L
C
H
C
D
L
L
S
S
N
I
I
N
T
VGG-D-------
S
--
I
-
S
F
--
I
D
F
E
Y
S
C
P
M
E
R
A
Y
D
I
A
N
H
F
N
E
Y
AGFNCDWDL
T
---
P
------------------
S
------------------
K
E
E
E
Y
H
F
I
M
H
Y
---------
L
G
T
D-
D
EE---
L
-------------
I
----------
N
Q
L
I
R
E
I
Q
P
F
Y
I
C
-----
S
H
I
N
W
G
L
W
S
L
L
Q
G
M
H
--------------------------------------------------
125
HHSearch
63.99
18%
-19
- C2 -
-
3C5I
3
?
D:
[34-331]
------------------------------------------
D
N
L
R
V
K
Q
I
L
--
L
T
N
-
Q
L
F
E
V
G
--------
L
K
---------
E
E
T
A
N
N
Y
NSIR
T
-
R
V
L
F
R
I
Y
G
K
H
-
V
D
E
-
L
Y
N
T
I
S
E
F
E
V
Y
K
T
M
S
K
Y
-
K
I
---
A
P
Q
L
L
N
T
F
N
G
---------
G
R
I
E
E
W
L
Y
-
G
D
-
P
---
L
R
I
D
D
L
-------------
K
N
P
T
I
L
I
G
I
A
N
V
L
G
K
F
H
T
L
S
R
K
R
--
H
-
L
PEH
W
---------------
D
RTP
C
-
I
F
K
M
M
E
K
W
K
N
Q
L
F
K
---------------
Y
KN---
I
EKY----
N
--------
C
D
I
H
K
-----------
Y
I
----
K
E
S
D
K
F
------
I
K
F
M
K
V
Y
S
KS
D
---
N
L
--
A
N
T
I
V
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
---
N
K-------
C
--
L
-
R
L
--
I
D
F
E
Y
S
G
F
N
F
L
A
T
D
I
A
N
F
F
I
E
T
---------
S
---
I
DYSVSSYPF
F
E
I
D
KKKYI
S
------------------
Y
E
N
R
K
L
F
I
T
A
Y
---------
L
S
N
--
Y
L
DKVV
P
T
P
K
L
---------
I
----------
D
E
I
L
E
A
V
E
V
Q
A
L
G
-----
A
H
L
L
W
G
F
W
S
I
I
R
G
Y
---------------------------------------------------
107
SP3
63.19
17%
-20
- C2 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-------------------------------GSPAAWVE
R
L
F
G
-
Y
D
W
A
Q
Q
T
I
G
C
S
D
A
A
V
F
R
L
S
--------
A
Q
---------
G
----------
R
P
V
L
F
V
K
T
D
L
S
G
-
A
L
N
---
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
-
G
V
P--
C
A
A
V
L
D
V
V
T
E
-----
A
G
R
D
W
L
L
L
G
E
V
P
-
G
Q
-
D
---
L
L
S
S
H
L
------------
A
P
A
E
-
K
V
S
I
M
A
D
A
M
R
R
L
H
T
L
D
P
A
T
--
C
-
P
---
F
---------------
D
-----
H
--
Q
A
K
H
R
I
E
R
A
R
T
---------------
R
-----
M
-------
E
--------
A
GLVDQDDLDEEH---
Q
G
----
L
A
P
A
E
L
------
F
A
R
L
K
A
R
M
--
P
---
D
---
G
E
D
L
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
---
N
--------
G
RF
S
-
G
F
--
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
---------
A
E
E
-
L
------------------
G
------------------
G
E
W
A
D
R
F
L
V
L
Y
---------
G
I
A
--
A
-----
P
-------------
D
-------------
S
Q
R
I
A
F
Y
R
L
L
-----
D
E
F
F
-------------------------------------------------------------
108
SP3
61.98
15%
-5
- C2 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
----------------------------AKMRIS
P
E
L
K
K
L
I
E
K
-
Y
R
C
V
K
D
T
E
G
M
S
P
A
K
V
Y
K
L
V
--------
G
E
---------
N
----------
E
-
N
L
Y
L
K
M
T
D
S
R
Y
K
G
T
-
T
Y
D
V
E
R
E
K
D
M
M
L
W
L
E
G
K
-
L
P
---
V
P
K
V
L
H
F
E
R
H
-----
D
G
W
S
N
L
L
M
S
E
A
D
-
G
V
-
L
C
S
E
E
Y
E
D
E
Q
------------
S
P
E
K
-
I
I
E
L
Y
A
E
C
I
R
L
F
H
S
I
D
I
S
D
--
C
-
P
---
Y
---------------
T
NS---
L
D
S
R
L
A
E
L
D
Y
L
L
N
N
---------------
D
-----
L
-------
A
--------
D
---------------
V
D
----
C
E
N
W
E
E
DTPFKD
P
R
E
L
Y
D
F
L
--
K
---
T
E
K
P
E
E
E
L
V
F
S
H
G
D
L
G
D
S
N
I
F
V
K
---
D
--------
G
KV
S
-
G
F
--
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
---------
R
E
D
I
G
------------------
E
------------------
E
Q
Y
V
E
L
F
F
D
L
L
---------
G
I
K
--
P
-----
D
---------------------------
W
E
K
I
K
Y
Y
I
L
L
-----
D
E
L
F
-------------------------------------------------------------
140
HHSearch
60.21
17%
-7
- C2 -
-
5IWU
2
?
A:
[21-282]
-------------------------------------------
E
E
T
I
Q
F
N
E
S
G
L
D
F
-
Q
A
V
F
A
Q
--------
D
N
N--------
G
----------
I
-
D
W
V
L
R
L
P
R
R
E
-
D
V
--
M
P
R
T
K
V
E
K
Q
A
L
D
L
V
N
K
Y
-
A
I
SFQ
A
P
N
W
I
I
Y
T
-------
E
E
--
L
I
A
Y
K
K
L
D
-
G
V
-
P
---
A
G
T
I
D
H
NIGNYIWEIDIN
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
--
A
-
A
A--
L
---------------
D
L
V
V
H
T
P
E
E
A
R
M
S
M
K
Q
R
M
D
A
---------------
V
-----
R
-------
A
------------------------
K
F
----
G
V
G
E
N
L
------
W
N
R
W
Q
A
W
L
--
N
DDD
M
W
--
P
K
K
T
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
---
K
DA------
N
--
V
T
G
L
--
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
--------------
F
------------------
G
------------------
E
E
G
L
E
A
L
I
L
A
Y
---------
K
E
I
GG
Y
-----
Y
-------------
W
----------
P
K
M
K
E
H
I
I
E
L
N
A
A
-----
Y
P
V
S
I
A
E
F
A
L
-------------------------------------------------------