@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : G8SGH3_ACTS5: (2019-01-29 )
MSRPVPADLLEITDALLPGAPLDSARLAEHGNMHHVVLLPGIAAVRVSKRAGAAAELPRRVGILHAVAAAGMPFAVPEPMTAVTTFGERAAVAVSWIDGASLPEGTGDPTVFGPLLDALREVRISPELEAALHRPRRRADDGSGWADILNNQVIPRLPARWRDRVRQRSDELLAIEEVPASLVHGDLGGGNVHFGADGTLTGVLDWDMAILSDPAIDAALVATWHGWHMLRAATDEQIYRRAGAWDAAVGAGHLHAILRGRPLSNVDGFVRSVIAWLEDPGRCRDR
Atome Classification :
(20 SA)
.........10........20........30-----.........40---..-------.......50....-------....60........70.-.......------.80-----.....-----..---.----90........100--..--...-----------------.----------..-.110.----......120....-...130-----.-----......140.....---..150-.---..------.....160.......170...---....180-------------.........190....---.-..200.......210.......220...----....---230..----------.---------------....240.------......250.....--..260.......270.......280....---------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSRPV
P
A
D
L
L
E
I
T
D
A
LLPGAPL
D
S
A
R
L
AEH------GN
M
H
H
V
V
L
LP----G
I
-------
A
A
V
R
VSKRAG
A
A
A
-------
E
L
P
R
R
V
G
I
L
H
A
V
A
AA-G-MPFAVPE------
P
M
T
-----
A
V
T
TF-----GE---
R
----
A
A
V
A
V
S
WIDGA----SL--PEG-----------------T----------GD-P
T
V
F
G
----
P
L
L
D
A
L
R
EVRIS
P
-
E
L
E
A
A
L
-----H-----RPRRRADDGS
G
W
A
D
---
I
LNN--Q---VI------PRL
P
A
R
W
R
D
R
V
R
QRSD
E
L
L
A
I
---
E
EV
P
A
---------------
S
L
VHGDLGGG
N
V
H
FGA---D-G
T
L
T
G
V
LDW
D
M
A
ILSDPAI
D
A
A
L
V
A
T
WH----G
W
H
M
---
L
R
AA
T
----------
D
---------------
E
Q
I
Y
R
RAG------AWDAAVG
A
G
H
L
H
A
I
--LRGRPL
S
N
V
D
G
F
V
R
S
V
I
A
W
LEDPGRCRDR---------
45
HHSearch
89.82
17%
-59
* C1 *
-
3TDW
1
?
A:
[4-286]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I
S
I
Q
S
V
E
S
L
G
E
------
G
F
R
N
Y
A
I
L
V
N
----
G
D
-------
W
V
F
R
F
P
K
S
Q
Q
G
A
D
-------
E
L
N
K
E
I
Q
L
L
P
L
L
V
G
C
---
V
K
V
N
I
P
Q
------
Y
V
Y
-----
I
G
K
R
S
-----
D
G
---
N
----
P
F
V
G
Y
R
K
V
Q
G
Q
----
I
L
--
G
E
D
G
M
A
V
LP
D
D
A
K
-------
D
----------
R
L
-
A
L
Q
L
A
----
E
F
M
N
E
L
S
A
F
P
V
E
T
-
A
I
S
A
G
V
-----
P
-----
V
T
N
L
K
N
K
-
I
L
L
L
S
E
---
A
V
E
D
--
Q
---
V
F
------
P
L
L
D
E
S
L
R
D
Y
L
T
L
R
F
Q
S
Y
M
T
H
PVY
T
R
Y
T
P
---------------
R
L
I
H
G
D
L
S
P
D
H
F
L
T
N
L
NSR
Q
-
T
P
L
T
G
I
I
D
F
G
D
A
A
I
S
D
P
D
Y
D
Y
V
Y
L
L
E
D
C
----
G
E
L
F
T
R
Q
V
M
A
Y
R
GEVD------
L
---------------
D
T
H
I
R
K
V
S
------
L
F
V
T
F
D
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
D
W
I
-------------------------------
52
HHSearch
85.84
21%
-39
- C1 -
-
5IGH
-
?
A:
[6-281]
--
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
K
L
H
G
P
L
T
V
N
E
L
------
G
L
D
Y
R
I
V
I
A
T
V
DDG
R
R
-------
W
V
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
---
L
P
F
A
V
P
D
------
W
R
V
-----
A
N
A
E
L
-----
V
A
---
Y
P
MLE
D
S
T
A
M
V
I
Q
P
G
S
----
S
T
--
P
D
W
V
V
P
QDS-----------
E
----------
V
F
-
A
E
S
F
A
----
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
-----
L
-----
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
---
D
V
D
R
--
V
----
R
------
R
E
F
V
--
V
N
D
K
R
L
H
R
W
Q
R
W
L
D
D
DSS
W
P
D
F
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
----
G
E
E
G
---
L
A
K
L
L
L
T
Y
E
A
A
G
G
R
V
W
---------------
P
R
L
A
H
H
I
A
------
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
----------------------------------------
51
HHSearch
83.89
21%
-40
- C1 -
-
5IGI
3
?
A:
[6-281]
--
T
A
D
T
S
Q
L
Y
A
L
A
A
R
-
H
G
L
K
L
H
G
P
L
T
V
N
E
L
------
G
L
D
Y
R
I
V
I
A
T
V
DDG
R
R
-------
W
V
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
A
M
L
K
N
R
---
L
P
F
A
V
P
D
------
W
R
V
-----
A
N
A
E
L
-----
V
A
---
Y
PMLE
D
S
T
A
-
V
I
Q
P
G
S
----
S
T
--
P
D
W
VVPQDS-----------
E
----------
V
F
-
A
E
S
F
A
----
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
-----
L
-----
I
R
T
P
T
Q
A
-
R
Q
K
V
A
D
---
D
V
D
R
--
V
----
R
------
R
E
F
V
--
V
N
D
K
R
L
H
R
W
Q
R
W
L
D
D
DSS
W
P
D
F
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
----
G
E
E
G
---
L
A
K
L
L
L
T
Y
E
A
A
G
G
R
V
W
---------------
P
R
L
A
H
H
I
A
------
E
R
L
A
F
G
A
V
T
Y
A
L
F
A
----------------------------------------
61
HHSearch
81.21
15%
-70
- C1 -
-
4DCA
1
?
A:
[25-294]
---
L
D
A
E
I
Y
E
H
L
N
K
----
Q
I
K
I
N
E
L
R
Y
L
S
S
------
G
D
D
S
D
T
F
L
C
N
----
E
Q
-------
Y
V
V
K
V
P
K
R
D
S
V
R
I
-------
S
Q
K
R
E
L
E
L
Y
R
F
L
E
N
C
-
K
-
L
S
Y
Q
I
P
A
------
V
V
Y
-----
Q
S
-------------
D
----
R
F
N
I
M
K
Y
I
K
G
E
----
R
I
--
T
Y
E
Q
Y
H
K
LS
E
K
E
K
-------
D
----------
A
L
-
A
Y
D
E
A
----
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
L
F
S
-----
D
------
A
L
-
V
N
K
-
K
D
K
F
L
Q
---
D
K
K
L
--
L
I
S
I
L
E
K
E
----
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
S
N
AVL
F
K
Y
T
P
---------------
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
-----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
TDDF
G
K
E
F
---
G
R
K
V
L
K
Y
Y
QHKA---
P
---------------
E
V
A
E
R
K
A
E
------
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
----------------------------------------
64
HHSearch
77.30
15%
-58
- C1 -
-
3HAM
3
?
A:
[16-273]
-------------------
I
K
I
N
E
L
R
Y
L
S
S
------
G
D
D
S
D
T
F
L
C
N
----
E
Q
-------
Y
V
V
K
V
P
K
R
D
S
V
R
I
-------
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
-
K
-
L
S
Y
Q
I
P
A
------
V
V
Y
-----
Q
S
-------------
D
----
R
F
N
I
M
K
Y
I
K
G
E
----
R
I
--
T
Y
E
Q
Y
H
K
L------------
S
E
K
E
K
D
-----
A
L
-
A
Y
D
E
A
----
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
L
F
S
-----
D
------
A
L
-
V
N
K
-
K
D
K
F
L
Q
---
D
K
K
L
--
L
I
S
I
L
E
K
E
----
Q
L
L
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
AVL
F
K
Y
T
P
---------------
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
N
-----
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
TDDF
G
K
E
F
---
G
R
K
V
L
K
Y
Y
QHKA---
P
---------------
E
V
A
E
R
K
A
E
------
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
----------------------------------------
50
HHSearch
76.44
16%
-52
- C1 -
-
5UXA
-
?
A:
[2-248]
--
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
K
E
E
T
I
Q
F
N
E
S
------
G
L
D
F
Q
A
V
F
A
Q
D
NNG
I
D
-------
W
V
L
R
L
P
R
R
E
D
V
M
P
-------
R
T
K
V
E
K
Q
A
L
D
L
V
N
K
Y
-
A
-
I
S
F
Q
A
P
N
------
W
I
I
-----
Y
T
-------------
E
----
E
L
I
A
Y
K
K
L
D
G
V
----
P
A
--
G
T
I
DHNIGNYIWEIDINNVP
E
----------
L
F
-
H
K
S
L
G
----
R
V
L
A
E
L
H
S
I
P
S
N
K
-
A
A
A
L
D
L
-----
V
-----
V
H
T
P
E
E
A
-
R
M
S
M
K
Q
---
R
M
D
A
--
V
---
R
-------
A
K
F
G
--
V
G
E
N
L
W
N
R
W
Q
A
W
L
N
D
DDM
W
P
K
K
T
---------------
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
---
D
-
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
F
----
G
E
E
G
---
L
E
A
L
I
----------------------------------------------------------------------------------------------
49
HHSearch
76.22
16%
-45
- C1 -
-
5IWU
2
?
A:
[1-248]
-
M
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
K
E
E
T
I
Q
F
N
E
S
------
G
L
D
F
Q
A
V
F
A
Q
D
NNG
I
D
-------
W
V
L
R
L
P
R
R
E
D
V
M
P
-------
R
T
K
V
E
K
Q
A
L
D
L
V
N
K
Y
-
A
-
I
S
F
Q
A
P
N
------
W
I
I
-----
Y
T
-------------
E
----
E
L
I
A
Y
K
K
L
D
G
V
----
P
A
--
G
T
I
DHNIGNYIWEIDINNVP
E
----------
L
F
-
H
K
S
L
G
----
R
V
L
A
E
L
H
S
I
P
S
N
K
-
A
A
A
L
D
L
-----
V
-----
V
H
T
P
E
E
A
-
R
M
S
M
K
Q
---
R
M
D
A
--
V
---
R
-------
A
K
F
G
--
V
G
E
N
L
W
N
R
W
Q
A
W
L
N
D
DDM
W
P
K
K
T
---------------
G
L
I
H
G
D
V
H
A
G
H
T
M
I
D
K
---
D
-
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
F
----
G
E
E
G
---
L
E
A
L
I
----------------------------------------------------------------------------------------------
46
HHSearch
75.33
14%
-41
- C- -
-
3N4U
-
?
A:
[1-286]
M
R
T
Y
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
------
G
N
D
C
I
A
Y
E
I
N
----
R
D
-------
F
I
F
K
F
P
K
H
S
R
G
S
T
-------
N
L
F
N
E
V
N
I
L
K
R
I
H
N
K
---
L
P
L
P
I
P
E
------
V
V
F
-----
T
G
M
P
S
ET---
Y
Q
---
M
----
S
F
A
G
F
T
K
I
K
G
V
----
P
L
--
T
P
L
-----------------
L
L
N
N
LP
K
Q
S
Q
N
Q
A
-
A
K
D
L
A
----
R
F
L
S
E
L
H
S
I
N
I
S
G
-
F
K
S
N
L
V
-----
L
-----
D
F
--
R
E
K
-
I
N
E
D
N
K
---
K
I
K
K
--
L
---
L
S
------
R
E
L
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
P
---------------
C
L
I
H
N
D
F
S
S
D
H
I
L
F
D
T
---
E
K
N
T
I
C
G
I
I
D
F
G
D
A
A
I
S
D
P
D
N
D
F
I
S
L
M
E
D
D
EEY-
G
M
E
F
---
V
S
K
I
L
N
H
Y
KHKD---
I
---------------
P
T
V
L
E
K
Y
R
------
M
K
E
K
Y
W
S
F
E
K
I
I
Y
G
K
E
Y
G
Y
M
D
---------------------------------
53
HHSearch
72.63
11%
-35
- C1 -
-
5IQC
2
AACA_STAAU
A:
[10-289]
---
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
K
V
D
S
I
E
I
I
G
S
------
G
Y
D
S
V
A
Y
L
V
N
----
N
E
-------
Y
I
F
K
T
K
F
S
T
N
K
K
K
-------
G
Y
A
K
E
K
A
I
Y
N
F
L
N
T
N
-
L
E
T
N
V
K
I
P
N
------
I
E
Y
-----
S
Y
I
S
------
D
E
---
L
----
S
I
L
G
Y
K
E
I
K
G
T
----
F
L
--
T
P
E
I
Y
S
T
MS
E
E
E
Q
-------
N
----------
L
L
-
K
R
D
I
A
----
S
F
L
R
Q
M
H
G
L
D
Y
T
D
-
I
S
E
C
T
I
-----
D
-------
N
K
Q
N
V
-
L
E
E
Y
I
L
---
L
R
E
T
------
I
Y
------
N
D
L
T
D
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
TV-
F
E
G
K
K
---------------
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
-
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
S
EEEI
G
T
N
F
---
G
E
D
I
L
R
M
Y
GNID---
I
---------------
E
K
A
K
E
Y
Q
D
------
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
---------------------------------
54
HHSearch
72.50
11%
-39
- C1 -
-
5IQI
1
AACA_STAAU
C:
[9-289]
--
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
K
V
D
S
I
E
I
I
G
S
------
G
Y
D
S
V
A
Y
L
V
N
----
N
E
-------
Y
I
F
K
T
K
F
S
T
N
K
K
K
-------
G
F
A
K
E
K
A
I
Y
N
F
L
N
T
N
-
L
E
T
N
V
K
I
P
N
------
I
E
Y
-----
S
Y
I
S
------
D
E
---
L
----
S
I
L
G
Y
K
E
I
K
G
T
----
F
L
--
T
P
E
I
Y
S
T
MS
E
E
E
Q
-------
N
----------
L
L
-
K
R
D
I
A
----
S
F
L
R
Q
M
H
G
L
D
Y
T
D
-
I
S
E
C
T
I
-----
D
-----
N
K
--
Q
N
V
-
L
E
E
Y
I
L
---
L
R
E
T
------
I
Y
------
N
D
L
T
D
I
E
K
D
Y
I
E
S
F
M
E
R
L
N
A
T
TV-
F
E
G
K
K
---------------
C
L
C
H
N
D
F
S
C
N
H
L
L
L
D
G
---
N
-
N
R
L
T
G
I
I
D
F
G
D
S
G
I
I
D
E
Y
C
D
F
I
Y
L
L
E
D
S
EEEI
G
T
N
F
---
G
E
D
I
L
R
M
Y
GNID---
I
---------------
E
K
A
K
E
Y
Q
D
------
I
V
E
E
Y
Y
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
---------------------------------
31
Fugue
69.79
14%
-14
- C1 -
-
3HAM
3
?
A:
[1-299]
M
V
N
L
D
----
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
L
R
Y
L
S
S
------
G
D
D
S
D
T
F
L
C
N
----
E
Q
-------
Y
V
V
K
V
P
K
R
D
S
V
R
I
-------
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
-
K
-
L
S
Y
Q
I
P
A
------
V
V
Y
QSDR
F
N
I
M
K
Y
-----
I
K
---
G
----
E
R
I
T
Y
E
Q
Y
H
K
L
----
S
E
--
K
E
K
-----------------
D
----------
A
L
-
A
Y
D
E
A
----
T
F
L
K
E
L
H
S
I
E
I
D
C
-
S
V
S
L
F
S
-----
D
ALVN
K
K
D
K
F
L
Q
D
K
K
L
L
I
S
I
---
L
E
K
E
--
Q
---
L
L
------
T
D
E
M
L
E
H
I
E
T
I
Y
E
N
I
L
N
N
A
V
L
---
F
K
Y
T
P
---------------
C
L
V
H
N
D
F
S
A
N
N
M
I
F
R
----
N
-
N
R
L
F
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
C
S
TDDF
G
K
E
F
---
G
R
K
V
L
K
Y
Y
QHKA---
P
---------------
E
V
A
E
R
K
A
E
------
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
--
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
------------
36
Fugue
69.48
15%
-30
- C1 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
---
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
A
P
E
V
T
V
E
S
G
VDSTGM
S
S
E
T
I
I
L
T
A
R
----
W
Q
Q
DG
R
S
I
Q
Q
K
L
V
A
R
V
A
P
A
A
E
D
VPVFPTY
R
L
D
H
Q
F
E
V
I
R
L
V
G
E
L
T
D
-
V
P
V
P
R
V
R
------
W
I
E
-----
T
T
G
D
V
-----
L
G
---
T
----
P
F
F
L
M
D
Y
V
E
G
V
V
PPD
V
M
--
P
Y
T
-----------------
F
----------
G
D
-
N
W
F
A
D
----
A
P
A
E
R
Q
R
Q
L
Q
D
A
T
V
A
A
L
A
T
L
-----
H
-----
S
I
P
N
A
Q
N
T
F
S
F
L
T
D
---
T
T
L
H
--
R
----
H
------
F
N
W
V
R
S
W
Y
D
F
A
V
E
G
I
G
R
S
P
L
L
---
E
R
T
F
E
W
L
Q
S
H
WP
D
D
A
A
A
REP
V
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
----
D
-
F
Q
P
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
----
R
V
F
Q
---
E
L
A
G
L
----------
A
TLPGLPEVMR
E
D
D
V
R
A
T
Y
Q
A
L
T
G
V
E
L
G
DL
H
W
F
Y
V
Y
S
G
V
M
W
A
C
V
--
F
M
R
T
G
A
R
R
V
H
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
EEH
5
PsiBlast_PDB
69.12
25%
-34
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[61-261]
-------------------------------------------------------------------------------
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
-
G
-
L
S
C
P
L
P
L
------
P
R
K
-----
D
G
E
L
L
-----
G
E
L
SG
R
----
P
A
A
L
I
S
F
L
E
G
M
----
W
L
RK
P
E
A
-----------------
K
----------
H
C
-
R
E
V
-
G
----
K
A
L
A
A
M
H
L
A
S
E
G
F
-
E
I
K
--------------
R
P
N
A
L
S
V
D
G
--
W
K
V
---
L
W
D
K
S
E
E
---
R
A
------
D
E
V
E
K
G
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
WP-
K
D
L
P
A
---------------
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
---
D
--
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
--
N
----
A
W
--------------------------------------
C
F
E
K
D
G
------
A
Y
N
V
T
K
G
K
A
L
L
E
G
Y
--
Q
S
V
R
P
L
S
E
A
E
----------------------------
65
HHSearch
68.34
20%
-33
- C1 -
-
2PPQ
-
KHSE_AGRFC
A:
[6-231]
--
D
I
T
E
D
E
L
R
N
F
L
T
Q
-
Y
D
V
G
S
L
T
S
Y
K
G
I
A
E
---------
N
S
N
F
L
L
H
T
T
K
-
D
P
-------
L
I
L
T
L
Y
E
K
---
K
N
-------
D
L
P
F
F
L
G
L
M
Q
H
L
A
A
K
----
G
L
S
C
P
L
------
P
L
P
-----
R
K
D
G
E
L
L
G
E
L
S
G
---
R
----
P
A
A
L
I
S
F
L
E
G
M
----
W
L
--
R
K
P
-----------------
E
A
---------
K
H
-
C
R
E
V
G
----
K
A
L
A
A
M
H
L
A
S
E
G
F
-
E
I
K
-
R
------
P
-----
N
---
A
L
S
-
V
D
G
W
K
V
---
L
W
D
K
--
S
---
E
E
RA----
D
E
V
E
K
G
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
WP-
K
D
L
P
A
---------------
G
V
I
H
A
D
L
F
Q
D
N
V
F
F
L
G
-----
D
E
L
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
--------------------------------------------------------------------------------------------------------------
67
SP3
66.31
12%
-14
- C1 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
---
G
S
P
A
A
W
----
V
E
R
L
F
G
Y
D
W
A
Q
Q
T
I
G
C
S
------
D
A
A
V
F
R
L
S
A
Q
----
G
R
P
V
-----
L
F
V
K
T
D
L
S
-
G
A
L
N
-------
E
L
Q
D
E
A
A
R
L
S
W
L
A
T
T
-
G
-
V
P
C
A
A
V
L
------
D
V
V
-----
T
E
A
--------
G
---
R
----
D
W
L
L
L
G
E
V
P
G
Q
----
D
L
--
L
S
S
-----------------
H
----------
L
A
P
A
E
K
V
S
----
I
M
A
D
A
M
R
R
L
H
T
L
D
-
P
A
T
C
P
F
-----
D
-----
H
Q
A
K
--
H
R
I
E
R
A
R
T
---
R
M
E
A
--
G
---
L
V
DQDDLD
E
E
H
Q
G
L
A
P
A
E
L
F
A
R
L
K
A
R
M
P
D
---
G
E
-
D
L
---------------
V
V
T
H
G
D
A
C
L
P
N
I
M
V
E
----
N
-
G
R
F
S
G
F
I
D
C
G
R
L
G
V
A
D
R
Y
Q
D
I
A
L
A
T
R
D
I
----
A
E
E
L
----
G
G
E
W
----------
A
---------------
D
R
F
L
V
L
Y
G
------
I
--
A
A
P
D
S
Q
R
I
A
F
Y
--
R
L
L
D
E
F
F
-------------------------------
13
PsiBlast_PDB
66.15
26%
9
- C1 -
-
5IGR
3
?
A:
[51-233]
-------------------------------------------------------------
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
-
L
P
F
A
V
P
D
WRVANA
E
L
V
-----
A
Y
P
M
L
-----
E
D
---
S
----
T
A
M
V
I
Q
--
P
G
S
----
S
T
--
P
D
W
-----------------
V
VP--------
Q
D
-
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
L
I
R
T
P
T
-----
Q
A
R
Q
K
V
A
D
D
V
D
R
V
R
R
E
F
V
V
N
D
--
K
---
R
L
------
H
R
W
-
Q
R
W
L
D
D
D
S
S
W
P
D
F
-----------
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.08
26%
11
- C1 -
-
5IGT
3
?
A:
[51-233]
-------------------------------------------------------------
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
-
L
P
F
A
V
P
D
WRVANA
E
L
V
-----
A
Y
P
M
L
-----
E
D
---
S
----
T
A
M
V
I
Q
--
P
G
S
----
S
T
--
P
D
W
-----------------
V
VP--------
Q
D
-
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
LIRT
P
T
-----
Q
A
R
Q
K
V
A
D
D
V
D
R
V
R
R
E
F
V
V
N
D
--
K
---
R
L
------
H
R
W
-
Q
R
W
L
D
D
D
S
S
W
P
D
F
-----------
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
66.00
26%
10
- C1 -
-
5IGP
3
?
A:
[51-233]
-------------------------------------------------------------
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
-
L
P
F
A
V
P
D
WRVANA
E
L
V
-----
A
Y
P
M
L
-----
E
D
---
S
----
T
A
M
V
I
Q
--
P
G
S
----
S
T
--
P
D
W
-----------------
V
VP--------
Q
D
-
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
L
I
R
T
P
T
-----
Q
A
R
Q
K
V
A
D
D
V
D
R
V
R
R
E
F
V
V
N
D
--
K
---
R
L
------
H
R
W
-
Q
R
W
L
D
D
D
S
S
W
P
D
F
-----------
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
65.90
26%
9
- C1 -
-
5IGJ
3
?
A:
[51-233]
-------------------------------------------------------------
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
-
L
P
F
A
V
P
D
WRVANA
E
L
V
-----
A
Y
P
M
L
-----
E
D
---
S
----
T
A
M
V
I
Q
--
P
G
S
----
S
T
--
P
D
W
-----------------
V
VP--------
Q
D
-
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
LIRT
P
T
-----
Q
A
R
Q
K
V
A
D
D
V
D
R
V
R
R
E
F
V
V
N
D
--
K
---
R
L
------
H
R
W
-
Q
R
W
L
D
D
D
S
S
W
P
D
F
-----------
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.55
26%
9
- C1 -
-
5IGS
3
?
A:
[51-233]
-------------------------------------------------------------
L
R
I
P
R
R
A
E
V
S
A
-------
K
V
E
P
E
A
R
V
L
-
A
M
L
K
N
-
R
-
L
P
F
A
V
P
D
WRVANA
E
L
V
-----
A
Y
P
M
L
-----
E
D
---
S
----
T
A
M
V
I
Q
--
P
G
S
----
S
T
--
P
D
W
-----------------
V
VP--------
Q
D
-
S
E
V
F
A
E
S
F
A
T
A
L
A
A
L
H
A
V
P
I
S
A
-
A
V
D
A
G
M
L
I
R
T
P
T
-----
Q
A
R
Q
K
V
A
D
D
V
D
R
V
R
R
E
F
V
V
N
D
--
K
---
R
L
------
H
R
W
-
Q
R
W
L
D
D
D
S
S
W
P
D
F
-----------
S
---------------
V
V
V
H
G
D
L
Y
V
G
H
V
L
I
D
N
---
T
-
E
R
V
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
--------------------------------------------------------------------------------------------------------------------