@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : J0VYS4_RHILT: (2019-01-30 )
MTELNASEFRSLITSVFPELTASVFKLAAKSWDSLAVDVDDTLIFKFPRHPAAERALVKEAGVLDIVRPSLSMAVPDMHIHDGPPIFSSHAKLDGEHLIAEDYDALGQGVRRHLADDLARFYAELHVLDADRLRQAGVGAIQPWQSPDAVRTKALPLLPPDIGRFAEAVIADFEALPPDPHGTVFGFFDGHGWNMAFDHAQGRLNGIYDFADSGFGPLHQEFIYSNFISADLTARIVSAYEMLTGRKLDRRRIAILTGFHRLSELAELADDPAHVDLMVQNVATWAAVAAHVG
Atome Classification :
(20 SA)
.........10........20........30........40---.-........50........60......-..70.--......-.---.80--..--.-----..------....90........100...-------.----...110.......120.......130.......--140-.--...-.----.-..150..----.---..------..160..---.....170---....---...180.......190.------......200.....-------....210....-...220....----.-----..230.......240...--..-.-.-250....--..--.260.......270.......280.....---..290.-
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTEL
N
A
S
E
F
R
S
L
I
T
S
V
F
P
E
L
T
A
S
V
F
K
L
A
A
KSWD
S
L
A
VDVD----D-
T
L
I
F
KFPRHP
A
A
E
R
A
L
V
K
EAG
V
L
D
IV-RPS-L--SMAVPD-M---HI---HD--G-----PP------I
F
S
S
HAKLDG
E
H
L
I
A
E
D
Y
D
A
-------
L
----
G
Q
G
V
R
R
H
L
A
D
D
L
A
R
F
Y
A
E
L
HVL
D
A
D
R
L
R
Q
AGVG--A-I-Q--PWQ-S----P-DAVRTKA----L---PL------LPP
D
I
G
R
---
F
A
E
A
V
I
A
D
---
F
EAL---PPDPHG
T
V
F
G
F
FDGHGW------NMAFDHA--QGRLN-------
G
I
Y
DFADSGF
G
-
P
L
H
Q
E
F
I
Y
S
N
----F-----I
S
A
D
L
T
A
R
I
V
S
A
Y
E
M
L
TG--RK-L-D-
R
R
R
I
A
I
L
--
T
G
--
F
H
R
L
S
E
L
A
E
LADDP
A
H
V
D
L
M
V
Q
N
V
A
T
W
A
A
---
V
A
AHVG-
19
PsiBlast_PDB
83.01
22%
-47
- C7 -
-
3TDW
1
?
A:
[4-276]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
----
G
-
D
W
V
F
R
F
P
K
S
Q
Q
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
-
V
G
C
-
V
--
K
V
N
I
P
Q
Y
V
---
Y
I
G
K
R
S
D
--
G
-----
N
P
-------
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
G
M
A
V
-------
L
----
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
P
--
V
-
T
-
N
--
L
K
N
-
K
I
L
L
L
S
-
E
A
V
E
D
Q
V
----
F
---
P
L
------
L
D
E
S
L
R
D
---
Y
---
L
T
L
R
---
F
Q
S
Y
---
M
T
H
P
V
Y
T
R
Y
T
P
R
L
I
H
G
-------
D
L
S
P
D
H
F
--
L
T
N
L
N
SRQTPLT
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
Y
D
Y
V
Y
L
L
----
E
-----
D
C
G
E
L
F
T
R
Q
V
M
A
Y
R
G
E
V
D
--
L
D
-
T
-
H
-
I
R
K
V
S
L
F
--
V
T
--
F
D
Q
V
S
Y
L
L
E
------------------------------
37
HHSearch
78.59
17%
-29
- C7 -
-
3TDW
1
?
A:
[4-297]
----
N
K
L
H
Y
T
T
M
I
M
T
Q
F
P
D
I
S
I
Q
S
V
E
S
L
G
E
G
F
R
N
Y
A
I
L
V
N
----
G
-
D
W
V
F
R
F
P
K
S
Q
Q
G
A
D
E
L
N
K
E
I
Q
L
L
P
L
L
-
V
G
C
-
V
--
K
V
N
I
P
Q
-
Y
---
V
Y
---
I
G
--
K
R
SD--
G
N
------
P
F
V
G
Y
R
K
V
Q
G
Q
I
L
G
E
D
G
M
A
V
-------
L
----
P
D
D
A
K
D
R
L
A
L
Q
L
A
E
F
M
N
E
L
S
A
F
P
V
E
T
A
I
S
A
G
V
P
----
V
-
T
--
N
L
K
-
N
----
K
I
L
L
L
S
E
A
V
E
D
QV
F
---
P
L
------
L
D
E
S
L
R
D
---
Y
L
T
L
R
F
Q
S
---
Y
M
T
H
PVY
T
R
Y
T
P
R
L
I
H
G
--
D
L
S
P
D
------
H
F
L
T
N
L
N
SR
Q
T
P
L
T
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
Y
D
Y
V
Y
L
L
E---
D
-----
C
G
E
L
-
F
T
R
Q
V
M
A
Y
R
G
E
V
D
L
D
T
H
-
I
-
R
-
K
V
S
L
F
V
T
--
F
D
--
Q
V
S
Y
L
L
E
G
L
R
A
R
D
Q
D
W
I
S
E
G
L
E
L
L
E
E
D
K
-----------
38
HHSearch
77.89
17%
-29
- C- -
-
3N4U
-
?
A:
[1-294]
M
R
T
Y
T
F
D
Q
V
E
K
A
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
---
V
F
---
T
G
--
M
P
S
ETY
Q
M
------
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
D-
F
-
R
-
E
--
K
I
N
-
E
----
D
N
K
K
I
K
K
L
L
----
S
---
R
E
------
L
K
G
P
Q
M
K
---
K
V
D
D
F
Y
R
D
---
I
L
E
N
EIY
F
K
Y
Y
P
C
L
I
H
N
--
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
S
L
M
EDDE
E
-----
Y
G
M
E
F
V
S
K
I
L
N
H
Y
K
H
K
D
I
--
P
T
V
L
-
E
-
K
Y
R
M
K
E
K
--
Y
W
--
S
F
E
K
I
I
Y
G
K
E
Y
G
Y
M
D
W
Y
E
E
G
L
N
E
----------------
40
HHSearch
74.58
17%
-15
- C7 -
-
5IQC
2
AACA_STAAU
A:
[9-302]
--
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
----
N
-
E
Y
I
F
K
T
K
F
S
T
N
K
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
-
N
T
N
-
L
ET
N
V
K
I
P
N
-
I
---
E
Y
---
S
Y
--
I
S
D---
E
L
------
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
S
T
-------
M
----
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
T
I
D
--
N
K
Q
-
N
--
V
L
E
-
E
----
Y
-
I
L
L
R
E
T
I
----
Y
---
N
D
------
L
T
D
I
E
K
D
---
Y
I
E
S
F
M
E
R
---
L
N
A
T
TV-
F
E
G
K
K
C
L
C
H
N
--
D
F
S
C
N
------
H
L
L
L
D
G
---
N
N
R
L
T
-------
G
I
I
D
F
G
D
S
G
I
I
-
D
E
Y
C
D
F
I
Y
L
L
E---
D
SEEE-
I
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D
I
--
E
K
-
A
K
E
-
Y
Q
D
I
V
E
E
--
Y
Y
--
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
T
-----------
39
HHSearch
74.33
17%
-16
* C7 *
-
5IQI
1
AACA_STAAU
C:
[9-302]
--
A
T
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
----
N
-
E
Y
I
F
K
T
K
F
S
T
N
K
K
K
G
F
A
K
E
K
A
I
Y
N
F
L
-
N
T
N
-
L
ET
N
V
K
I
P
N
-
I
---
E
Y
---
S
Y
I
S
D
-----
E
L
------
S
I
L
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
S
T
-------
M
----
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
T
I
D
--
N
-
K
Q
N
--
V
L
E
-
E
----
Y
-
I
L
L
R
E
T
I
----
Y
---
N
D
------
L
T
D
I
E
K
D
---
Y
I
E
S
F
M
E
R
---
L
N
A
T
TV-
F
E
G
K
K
C
L
C
H
N
--
D
F
S
C
N
------
H
L
L
L
D
G
---
N
N
R
L
T
-------
G
I
I
D
F
G
D
S
G
I
I
-
D
E
Y
C
D
F
I
Y
L
L
----
E
DSEEE
I
G
T
N
F
G
E
D
I
L
R
M
Y
G
N
I
D
I
--
E
K
-
A
-
K
E
Y
Q
D
I
V
E
E
--
Y
Y
--
P
I
E
T
I
V
Y
G
I
K
N
I
K
Q
E
F
I
E
N
G
R
K
E
I
Y
K
R
T
-----------
14
PsiBlast_PDB
71.12
23%
-150
- C- -
-
4DBX
-
?
A:
[13-231]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
45
HHSearch
69.85
15%
-18
- C7 -
-
5UXA
-
?
A:
[2-298]
--
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
K
E
E
T
I
Q
F
N
E
S
G
L
D
F
Q
A
V
F
A
Q
D
NN-
G
I
D
W
V
L
R
L
P
R
R
E
D
V
M
P
R
T
K
V
E
K
Q
A
L
D
L
V
-
N
K
Y
A
I
--
S
F
Q
A
P
N
-
W
---
I
I
---
Y
T
---------
E
------
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
D
H
N
I
GNYIWEI
D
----
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
A
A
A
L
D
L
V
--
V
-
H
-
T
P
E
E
A
R
M
S
----
M
-
K
Q
R
M
D
A
V
----
R
---
A
K
------
F
G
V
-
G
E
N
---
L
W
N
R
W
Q
-
A
---
W
L
N
D
DDM
W
P
K
K
T
G
L
I
H
G
--
D
V
H
A
G
------
H
T
M
I
D
K
---
D
A
N
V
T
-------
G
L
I
D
W
T
E
A
K
V
T
-
D
V
S
H
D
F
I
F
N
Y
R
---
A
-----
F
G
E
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
G
--
Y
Y
-
W
-
P
-
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
G
I
E
E
Y
E
Q
M
A
K
E
A
L
E
--------------
46
HHSearch
69.69
15%
-10
- C7 -
-
5IWU
2
?
A:
[1-298]
-
M
S
K
D
I
K
Q
V
I
E
I
A
K
K
H
N
L
F
L
K
E
E
T
I
Q
F
N
E
S
G
L
D
F
Q
A
V
F
A
Q
D
NN-
G
I
D
W
V
L
R
L
P
R
R
E
D
V
M
P
R
T
K
V
E
K
Q
A
L
D
L
V
-
N
K
Y
A
I
--
S
F
Q
A
P
N
-
W
---
I
I
---
Y
T
---------
E
------
E
L
I
A
Y
K
K
L
D
G
V
P
A
G
T
I
D
H
N
I
GNYIWEI
D
----
I
N
N
V
P
E
L
F
H
K
S
L
G
R
V
L
A
E
L
H
S
I
P
S
N
K
A
A
A
L
D
L
V
--
V
-
H
-
T
P
E
E
A
R
M
S
----
M
-
K
Q
R
M
D
A
V
----
R
---
A
K
------
F
G
V
-
G
E
N
---
L
W
N
R
W
Q
-
A
---
W
L
N
D
DDM
W
P
K
K
T
G
L
I
H
G
--
D
V
H
A
G
------
H
T
M
I
D
K
---
D
A
N
V
T
-------
G
L
I
D
W
T
E
A
K
V
T
-
D
V
S
H
D
F
I
F
N
Y
R
---
A
-----
F
G
E
E
G
L
E
A
L
I
L
A
Y
K
E
I
G
G
--
Y
Y
-
W
-
P
-
K
M
K
E
H
I
I
E
L
N
A
A
Y
P
V
S
I
A
E
F
A
L
V
S
G
I
E
E
Y
E
Q
M
A
K
E
A
L
E
--------------
20
PsiBlast_PDB
67.67
21%
-31
- C7 -
-
6CH4
1
AACA_STAAU
A:
[11-234]
----
N
V
K
A
M
K
Y
L
I
E
H
Y
F
D
N
F
K
V
D
S
I
E
I
I
G
S
G
Y
D
S
V
A
Y
L
V
N
----
N
-
E
Y
I
F
K
T
K
F
S
T
N
K
K
K
G
Y
A
K
E
K
A
I
Y
N
F
L
-
N
T
N
-
L
ET
N
V
K
I
P
N
-
I
E
Y
S
Y
I
---
S
D
--
E
-----
L
S
------
I
L
-
G
Y
K
E
I
K
G
T
F
L
T
P
E
I
Y
S
T
-------
M
----
S
E
E
E
Q
N
L
L
K
R
D
I
A
S
F
L
R
Q
M
H
G
L
D
Y
T
D
I
S
E
C
T
I
D
--
N
-
K
-
Q
--
N
V
L
-
E
----
E
-
Y
I
L
L
R
E
T
----
I
---
Y
N
------
D
L
T
D
I
E
K
D
--
Y
I
E
S
F
M
E
R
---
L
N
A
T
---
T
V
F
E
G
K
K
C
L
C
H
N
D
F
N
C
N
------
H
L
L
L
D
-
G
--
N
N
R
L
T
-------
G
I
I
D
F
G
D
S
G
I
I
-
D
E
Y
C
D
F
I
Y
-------------------------------------------------------------------------------------------
21
Fugue
65.66
14%
-8
- C7 -
-
3HAM
3
?
A:
[1-299]
M
V
N
L
----
D
A
E
I
Y
E
H
L
N
K
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
----
E
-
Q
Y
V
V
K
V
P
K
R
D
S
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
E
N
C
K
-
L
--
S
Y
Q
I
P
A
-
V
---
V
Y
---
Q
S
--
D
-----
R
--------
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
K
-------
L
----
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
F
S
D
--
A
-
L
-
V
--
N
K
K
-
D
----
K
-
F
L
Q
D
K
K
L
----
L
---
I
S
------
I
L
E
K
E
Q
L
---
L
T
D
E
M
L
E
H
---
I
E
T
I
---
Y
E
N
I
L
N
N
A
V
L
F
K
Y
T
P
C
L
VHNDFS
A
N
N
M
I
F
R
--
N
N
R
L
F
-------
G
V
I
D
F
G
D
F
N
V
G
D
P
D
N
D
F
L
C
L
L
D
----
C
-----
S
T
D
D
F
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
--
H
K
-
A
-
P
-
E
V
A
E
R
K
A
--
E
L
--
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
L
Q
T
Q
A
E
M
F
I
F
42
HHSearch
62.64
16%
-32
- C7 -
-
5UXD
2
?
A:
[2-295]
S
M
P
E
D
L
D
A
L
L
D
L
A
A
R
H
G
L
D
L
D
G
G
T
L
R
T
E
E
I
G
L
D
F
R
V
A
F
A
R
A
HDG
G
-
D
W
V
L
R
L
P
R
R
P
D
V
L
E
R
A
A
V
E
G
R
L
L
A
M
L
-
A
P
H
-
L
--
D
V
A
V
P
D
-
W
---
R
I
---
S
T
---------
S
------
E
L
I
A
Y
P
L
L
P
G
S
P
G
L
T
V
A
A
D
G
-------
E
V
S
W
H
V
D
M
A
S
T
V
Y
A
R
S
L
G
S
V
V
A
Q
L
H
A
V
D
A
E
A
A
A
A
T
G
I
E
V
R
S
-
P
-
A
--
Q
V
R
-
G
A
---
W
-
R
Q
D
L
A
R
V
----
G
---
A
E
F
E----
I
A
P
A
L
R
E
---
R
W
E
A
W
L
A
D
---
D
G
C
----
W
P
G
H
S
V
L
T
H
G
--
E
L
Y
P
A
------
H
T
L
V
E
D
----
E
R
I
T
-------
A
V
L
D
W
T
T
A
A
V
G
-
D
P
A
K
D
L
M
F
H
Q
V
---
S
-----
A
P
S
A
I
F
E
V
A
L
Q
A
Y
A
E
G
G
G
--
R
P
-
W
-
P
-
G
L
A
R
H
C
T
E
M
F
S
A
A
P
L
G
Y
G
L
Y
A
L
A
T
G
E
A
A
H
R
E
A
A
A
A
A
L
N
--------------
1
PsiBlast_PDB
62.47
23%
-18
- C7 -
-
4N57
1
?
A:
[33-251]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
Q
I
S
G
K
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
10
PsiBlast_PDB
62.22
23%
-13
- C7 -
-
3SG9
1
?
A:
[13-231]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
LSR
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
5
PsiBlast_PDB
62.16
23%
-10
- C7 -
-
3SG8
1
?
A:
[13-231]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
3
PsiBlast_PDB
62.09
23%
-13
- C7 -
-
5C4L
-
?
A:
[33-251]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
Q
I
S
G
K
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
12
PsiBlast_PDB
61.64
23%
-12
- C7 -
-
4DT8
1
?
A:
[13-231]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
SR
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
16
PsiBlast_PDB
61.56
23%
-16
- C7 -
-
4DFB
1
?
A:
[34-254]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
LSR
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
47
HHSearch
61.50
18%
-19
- C7 -
-
3HAM
3
?
A:
[15-250]
------------------
Q
I
K
I
N
E
L
R
Y
L
S
S
G
D
D
S
D
T
F
L
C
N
----
E
-
Q
Y
V
V
K
V
P
K
R
D
S
V
R
I
S
Q
K
R
E
F
E
L
Y
R
F
L
-
E
N
C
K
L
--
S
Y
Q
I
P
A
-
V
---
V
Y
---
Q
S
---------
D
------
R
F
N
I
M
K
Y
I
K
G
E
R
I
T
Y
E
Q
Y
H
K
-------
L
----
S
E
K
E
K
D
A
L
A
Y
D
E
A
T
F
L
K
E
L
H
S
I
E
I
D
C
S
V
S
L
F
S
D
A-
L
-
V
-
N
--
K
K
D
-
K
----
F
-
L
Q
D
K
K
L
L
----
I
---
S
I
L
E
K
E
QL
L
T
D
E
M
L
E
---
H
I
E
T
I
Y
E
N
---
I
L
N
N
AVL
F
K
Y
T
P
C
L
V
H
N
--
D
F
S
A
N
------
N
M
I
F
R
N
---
N
-
R
L
F
-------
G
V
I
D
F
G
D
F
N
V
G
-
D
P
D
N
D
F
L
C
L
L
D---
C
STDD-
F
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
K
A
--------------------------------------------------------------
7
PsiBlast_PDB
61.41
23%
-10
- C7 -
-
6CD7
-
?
A:
[14-232]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------
13
PsiBlast_PDB
61.18
23%
-8
- C7 -
-
4DT9
1
?
A:
[13-231]
------------
I
E
Q
L
Y
P
D
F
T
I
N
T
I
E
I
S
G
E
G
N
D
C
I
A
Y
E
I
N
----
R
-
D
F
I
F
K
F
P
K
H
S
R
G
S
T
N
L
F
N
E
V
N
I
L
K
R
I
-
H
N
K
-
L
--
P
L
P
I
P
E
-
V
----
V
---
F
T
--
G
-----
M
P
S
ETYQM
S
F
A
G
F
T
K
I
K
G
V
P
L
T
P
L
L
L
N
N
-------
L
----
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
R
F
L
S
E
L
H
S
I
N
I
S
G
F
K
S
N
L
V
L
--
D
-
F
-
R
--
E
K
I
-
N
----
E
-
D
N
K
K
I
K
K
----
L
L
S
R
E
L
------
K
G
P
Q
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
EIY
F
K
Y
Y
---
P
C
L
I
H
N
------
D
F
S
S
D
------
H
I
L
F
D
T
E
--
K
N
T
I
C
-------
G
I
I
D
F
G
D
A
A
I
S
-
D
P
D
N
D
F
I
--------------------------------------------------------------------------------------------