@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K2FWB2_9BACT: (2019-01-30 )
MGILEYTSQLDIEFKKALGLIFKQELNLERIKQGEVNYSYKVTSEQDIPLYHARIFRYEGHPDTEKLLWISGELKKRNIPQARILYREKSSINFPNGFMVSNWIEGKNGWQSIKDGAYSLKNFTLETAKILLKIHEIKVASFGWPYGKGWGYYNTYQDRITGLPNNDEFKKLFNNDYLKRKYVLNIVSLLLKALEKIPFPEQPILAHSDPTPDNIIVRNDRSLVLIDWDDSEGSWWVRDYSYLRYWSDKPEEIKAGFFSGYGKIDMNESEIEIAELVEWILQSLRLLPYYKFSFADEGKYQKRMTRLKENVRQLKLLV
Atome Classification :
(20 SA)
-------------------------......-...10-------------------...-.....20.---------.-------......30.....-.-..40....--------.--------...50----...----..--...--60-.--...-----....----.----70-.....-..--.80........90-----.---..-..-...100.....-..110.-...-...120......-.130.....-------..---------140.....------..---150--..-...--...-160-------....-...---.--.170...---.---..---..---180.-.......190.....-.-.-200..--------.....210.....--.--.--220----....---------------------.....230....--....240-----------.-.------..-----.------.--------.-----------------.250--....-...----..260-----...-...-------------.---------.270...-.....280---.......290-..----....---..-.300.......310......-------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-------------------------M
G
I
L
E
Y
-
T
S
QL
D
-------------------
I
E
F
-
K
K
A
L
G
L
I
F
---------
K
-------QEL
N
L
E
R
I
KQGE
V
-
N
-
Y
S
Y
K
VTSE--------Q--------DI
P
L
Y
----
H
A
R
----
I
F
--
R
YE--G--H--PDT-----
E
K
L
L
----
W
----IS-GELKK-RN--IPQ
A
R
I
L
Y
R
EKSS-----I---NF-PN-
G
F
M
V
S
N
W
IEGK-N
G
W
Q
S
I
-
K
DG-
A
Y
S
L
K
N
F
T
L
E
T
A
-
K
I
L
L
K
I
H
E
I
-------
K
V
---------ASFGWPYG------KG---WG---YY-
N
T
Y
--
Q
D
R
-I---------TGLP-N
N
D
---
E
--
F
K
K
-
L
F
N---
N
---
D
Y
---
L
K
---
R
-
K
Y
-
V
L
N
I
V
S
L
L
L
K
A
L
E
KI-P-F-PEQPI--------LAHSDPTPD
N
I
I
V
--R--N--D------
R
S
L
V
---------------------
L
I
DWDD-SEG
S
W
--
W
V
R
D
Y
-
S
-----------
Y
-
L
------
R
Y
-----W------S--------D-----------------
K
P
----
E
E
I
K
-
A
G
F
----FSGY------GKI-DM
N
-------------
E
---------
S
E
I
-
E
I
A
-
E
L
V
E
W
I
L
Q
---
S
L
R
LLP
Y
Y
---
K
F
----SFAD---E
G
-
K
Y
Q
K
R
M
T
R
L
K
E
N
V
R
Q
L
KLLV-------------------------------------------
49
HHSearch
76.13
16%
-5
- C4 -
-
1NW1
-
CKA2_CAEEL
B:
[52-396]
-----------------------------------
L
K
-------------------
E
R
A
-
H
M
L
C
A
R
F
L
G--------
G
AWKTVPL
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
-
M
L
F
L
C
R
L
S
EVYPPIRN
E
--------
P
N
-
K
V
----
L
L
R
----
V
Y
--
F
N
P
--
E
T-
E
--
S
H
L
-----
V
A
E
S
----
V
----
I
F
-
T
L
L
S
E
-
R
H
--
L
G
-
P
K
L
Y
G
I
F
----------------
S
-
G
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
------
I
S
L
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
-------
E
V
---------
P
I
W
K
E
P
D
Y
-------
L
---
C
E
---
A
L
-
Q
R
W
--
L
K
Q
-
L
---------
T
G
T
V
D
A
E
H
---
R
--
F
-
D
-
L
P
E
---
E
---
C
G
VSS
V
N
---
C
-
L
D
-
L
A
R
E
---
L
E
F
L
R
A
H
I
-
S
-
L
S
K
S
P
V
T
--------
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
--
K
----------
R
L
V
---------------------
L
I
D
F
E
Y
-
A
S
Y
N
Y
--
R
A
F
D
F
-
A
-----------
N
-
H
------
F
I
E
----
W
------
T
--------
I
DYDIDEAPF
Y
K
I
Q
TENF
P
E
----
N
D
Q
M
-
L
E
F
----
F
L
N
Y
------
L
R
E
-
Q
G
N
-------------
T
RENE
L
Y
K
K
S
E
D
L
-
V
Q
E
-
T
L
P
F
V
P
V
S
---
H
F
F
W
G
V
W
G
---
L
L
----
Q
V
E
----------------------------------------------------------------------
48
HHSearch
75.01
16%
-2
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[52-396]
-----------------------------------
L
K
-------------------
E
R
A
-
H
M
L
C
A
R
F
L
G--------
G
AWKTVPL
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
-
M
L
F
L
C
R
L
S
EVYPPIRN
E
--------
P
N
-
K
V
----
L
L
R
----
V
Y
--
F
N
P
--
E
T-
E
--
S
H
L
-----
V
A
E
S
----
V
----
I
F
-
T
L
L
S
E
-
R
H
--
L
G
-
P
K
L
Y
G
I
F
----------------
S
-
G
G
R
L
E
E
Y
I
P
S
R
-
P
L
S
C
H
E
------
I
S
L
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
-------
E
V
---------
P
I
W
K
E
P
D
Y
-------
L
---
C
E
---
A
L
-
Q
R
W
--
L
K
Q
-
L
---------
T
G
T
V
D
A
E
H
---
R
--
F
-
D
-
L
P
E
---
E
---
C
G
VSS
V
N
---
C
-
L
D
-
L
A
R
E
---
L
E
F
L
R
A
H
I
-
S
-
L
S
K
S
P
V
T
--------
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
--
K
----------
R
L
V
---------------------
L
I
D
F
E
Y
-
A
S
Y
N
Y
--
R
A
F
D
F
-
A
-----------
N
-
H
------
F
I
E
----
W
------
T
--------
I
DYDIDEAPF
Y
K
I
Q
TENF
P
E
----
N
D
Q
M
-
L
E
F
----
F
L
N
Y
------
L
R
E
-
Q
G
N
-------------
T
RENE
L
Y
K
K
S
E
D
L
-
V
Q
E
-
T
L
P
F
V
P
V
S
---
H
F
F
W
G
V
W
G
---
L
L
----
Q
V
E
----------------------------------------------------------------------
46
HHSearch
74.00
14%
-0
- C4 -
-
5FTG
11
CHKA_HUMAN
A:
[5-350]
--------------------------------
E
P
R
T
R
-------------------
R
R
A
-
Y
L
W
C
K
E
F
L
P--------
G
AWRGLRE
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
-
M
L
F
Q
C
S
L
P
--------
D
TTATLGDE
P
R
-
K
V
----
L
L
R
----
L
Y
--
G
----------
E
A
M
-----
V
L
E
S
----
V
----
M
F
-
A
I
L
A
E
-
R
S
--
L
G
-
P
K
L
Y
G
I
F
P
-----------------
Q
G
R
L
E
Q
F
I
P
S
R
-
R
L
D
T
E
E
------
L
S
L
P
D
I
S
A
E
I
A
-
E
K
M
A
T
F
H
G
M
-------
K
M
---------
P
F
N
K
E
P
K
W
-------
L
---
F
G
---
T
M
-
E
K
Y
--
L
K
E
-
V
---------
L
R
I
K
----------
F
T
E
-
E
S
R
---
I
---
K
K
---
L
H
K
L
L
S
-
Y
N
-
L
P
L
E
---
L
E
N
L
R
S
L
L
-
E
-
S
T
P
S
P
V
V
--------
F
C
H
N
D
C
Q
E
G
N
I
L
L
--
L
--
E
--
G
RENSEK
Q
K
L
M
---------------------
L
I
D
F
E
Y
-
S
S
Y
N
Y
--
R
G
F
D
I
-
G
-----------
N
-
H
------
F
C
-----
E
W-----
M
Y-------
D
YSYEKYPF
F
R
A
N
IRKY-
P
T
----
K
K
Q
Q
-
L
H
F
----
I
S
S
Y
------
L
P
A
-
F
Q
N
DFENLS
T
E
E
K
S
I
I
K
---------
E
E
M
-
L
L
E
-
V
N
R
F
A
L
A
S
---
H
F
L
W
G
L
W
S
---
I
V
----
Q
A
K
----------------------------------------------------------------------
37
Fugue
73.70
20%
42
- C4 -
-
4OCV
2
?
A:
[24-378]
-----------------------T
N
E
A
L
F
D
V
-
A
S
H
F
A
-------------------
L
E
-------------------
G
-------
T
V
D
S
I
E
P
Y
G
D
G
H
I
-
N
-
T
T
Y
L
V
T
T
------------------
D
G
P
R
Y
----
I
L
Q
----
R
M
--
N
T
G
--
I
--
F
--
P
D
T
-----
V
N
L
M
R
N
V
E
L
----
V
T
-
S
T
L
K
A
-
Q
G
--
K
E
T
L
D
I
V
R
---------------------------
T
T
S
G
-
D
T
W
A
E
I
-
D
G
G
-
A
W
R
V
Y
K
F
I
E
H
T
M
-
S
Y
N
L
V
P
N
P
D
-------
V
F
---------
R
E
A
G
R
A
F
G
------
D
F
---
Q
N
---
F
L
-
S
G
F
--
D
A
N
-
Q
LTETIAHFH
D
T
P
H
-
R
F
E
---
D
--
F
K
K
-
A
L
A
---
A
---
D
E
---
L
G
---
R
-
A
A
G
C
G
P
E
I
E
F
Y
L
S
H
A
D
Q
Y
-
A
-
V
-
V
M
D
G
L
R
D
GSIPLR
V
T
H
N
D
T
K
L
N
N
I
L
M
DA
T
--
T
--
G
------
K
A
R
A
---------------------
I
I
D
L
D
T
I
M
P
G
S
M
--
L
F
D
F
G
-
D
-----------
S
-
I
------
R
F
GASTA
L
------
E
--------
D
-----------------
E
R
----
D
L
D
K
-
V
H
F
S
T
E
L
F
R
A
Y
------
T
E
G
-
F
V
G
-------------
E
L
R
DSIT
A
--
R
E
A
-
E
L
L
-
P
F
S
G
N
L
L
T
M
E
C
G
M
R
F
L
A
D
Y
L
E
G
D
V
----
Y
F
A
T
---
K
Y
-
P
-
E
H
N
L
V
R
S
R
T
Q
I
K
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T--------------------------
25
Fugue
69.65
15%
-17
- C4 -
-
3I1A
2
?
A:
[3-330]
--------------------------
K
Q
P
I
Q
-
A
Q
Q
L
I
-------------------
E
L
L
-
K
V
H
Y
G
-
I
D
---------
I
-------
H
T
A
Q
F
I
Q
G
G
A
D
T
N
-
A
-
F
A
Y
Q
A
D
S
E
--------
S
----------
K
S
Y
----
F
I
K
----
L
K
--
Y
G
Y
--
H
--
D
--
E
I
N
-----
L
S
I
I
----
R
----
L
L
-
H
D
S
G
I
-
K
E
--
I
I
F
P
I
H
T
L
E
A
K
L
F
-----
Q
---
Q
L
-
K
H
F
K
I
I
A
Y
P
F
I
H
A
P
-
N
----
G
-
F
T
Q
-
N
L
T
-
G
K
Q
W
K
Q
L
G
-
K
V
L
R
Q
I
H
E
T
-------
S
V
P
I
S
I
Q
Q
Q
--
L
R
K
E
I
Y
S
P
------
K
W
---
R
E
---
I
V
-
R
S
F
--
Y
N
Q
-
I
---------
E
F
D
N
-
S
D
D
---
K
--
L
T
A
-
A
F
K
---
S
---
F
F
---
N
Q
N
--
S
-
A
A
-
I
H
R
L
V
D
T
S
E
K
L
S
K
K
I
-
Q
-
P
D
L
D
K
Y
V
--------
L
C
H
S
D
I
H
A
G
N
V
L
V
--
G
--
N
--
E
------
E
S
I
Y
---------------------
I
I
D
W
D
E
-
P
M
L
A
P
--
K
E
R
D
L
-
M
-----------
F
-
I
GGG---
V
G
-----
N
------
V
--------
W
-----------------
N
K
----
P
H
E
I
-
Q
Y
F
----
Y
E
G
Y
------
G
E
I
-
N
V
D
-------------
K
---------
T
I
L
-
S
Y
Y
-
R
H
E
R
I
V
E
D
---
I
A
V
Y
G
Q
D
L
---
L
S
----
R
N
Q
N
---
N
Q
-
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
N
N
V
V
E
I
A
F
A
T
E-------------------------------------
63
SP3
67.61
16%
34
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
--------------------------
G
M
K
E
L
-
L
S
T
M
D
LDTDANTI
P
E
L
K
E
R
A
H
M
L
C
A
R
F
L
G
G
A
W
K
T
V
P
---------
L
-------
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
-
M
L
F
L
C
R
L
S
--------
E
--------
V
Y
P
P
I
RNEP
N
K
V
----
L
L
--
R
V
Y
--
F
--
N
--
P
E
T
-----
E
S
H
L
----
V
A
E
S
V
I
F
-
T
L
L
S
E
-
R
H
--
L
G
-
P
K
L
Y
G
I
F
---------------
S
G
-
G
-
R
L
E
E
Y
I
P
S
R
-----
P
L
-
S
C
H
-
E
I
S
L
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
-------
E
V
---------
P
I
W
K
E
P
D
Y
------
L
C
E
A
L
Q
R
---
W
L
-
K
Q
L
--
T
G
T
-
V
---------
D
A
E
H
-
R
F
D
---
L
--
P
E
E
-
C
G
V
---
S
---
S
V
----
N
---
C
-
L
D
-
L
A
R
E
L
E
F
L
R
A
H
I
S
L
S
-
K
----
S
P
V
T
--------
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
--
K
--
R
--------
L
V
---------------------
L
I
D
F
E
Y
-
A
S
Y
N
Y
--
R
A
F
D
F
A
N
-----------
H
-
F
------
I
E
-----
W
------
T
--------
I
-----------------
D
Y
----
D
I
-----------
D
E
A
------
P
F
Y
-
K
I
Q
-------------
T
---------
E
N
F
P
E
N
D
-
Q
M
L
E
F
F
L
N
---
Y
L
R
--------
E
Q
----
G
N
T
R
---
E
N
-
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
V
ELSPVGFG
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
LA
45
HHSearch
67.22
14%
37
- C4 -
-
5FUT
10
CHKA_HUMAN
A:
[5-350]
--------------------------------
E
P
R
T
R
-------------------
R
R
A
-
Y
L
W
C
K
E
F
L
P--------
G
AWRGLRE
D
E
F
H
I
S
V
I
R
G
G
L
S
-
N
-
M
L
F
Q
C
S
L
P
--------
D
TTATLGDE
P
R
-
K
V
----
L
L
R
----
L
Y
--
G
--------G
A
E
A
M
-----
V
L
E
S
----
V
----
M
F
-
A
I
L
A
E
-
R
S
--
L
G
-
P
K
L
Y
G
I
F
P
-----------------
Q
G
R
L
E
Q
F
I
P
S
R
-
R
L
D
T
E
E
------
L
S
L
P
D
I
S
A
E
I
A
-
E
K
M
A
T
F
H
G
M
-------
K
M
---------
P
F
N
K
E
P
K
W
-------
L
---
F
G
---
T
M
-
E
K
Y
--
L
K
E
-
V
---------
L
R
I
K
----------
F
T
E
-
E
S
R
---
I
---
K
K
---
L
H
K
L
L
S
-
Y
N
-
L
P
L
E
---
L
E
N
L
R
S
L
L
-
E
-
S
T
P
S
P
V
V
--------
F
C
H
N
D
C
Q
E
G
N
I
L
L
--
L
--
E
--
G
RENSEK
Q
K
L
M
---------------------
L
I
D
F
E
Y
-
S
S
Y
N
Y
--
R
G
F
D
I
-
G
-----------
N
-
H
------
F
C
-----
E
W
-----
M
Y-------
D
YSYEKYPF
F
R
A
N
IRKY-
P
T
----
K
K
Q
Q
-
L
H
F
----
I
S
S
Y
------
L
P
A
-
F
Q
N
DFENLS
T
E
E
K
S
I
I
K
---------
E
E
M
-
L
L
E
-
V
N
R
F
A
L
A
S
---
H
F
L
W
G
L
W
S
---
I
V
----
Q
A
K
----------------------------------------------------------------------
40
HHSearch
66.22
18%
36
- C4 -
-
4R78
2
?
A:
[18-303]
--------------------------------
G
S
H
M
E
-------------------
K
I
I
-
K
E
K
I
S
S
L
L
SQE------
E
-------
E
V
L
S
V
E
Q
L
-
G
G
M
T
-
N
-
Q
N
Y
L
A
K
T
T
--------
N
---------
K
-
Q
Y
----
I
V
K
----
F
F
--
G
K
G
--
T
--
E
KL
I
N
R
-----
Q
D
E
K
----
Y
----
N
L
-
E
L
L
K
D
-
L
G
--
L
D
V
K
N
Y
L
F
D
--------------
I
-
E
A
-
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
S
T
S
--------
I
K
T
K
F
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
-------
A
K
---------
E
L
R
G
E
F
A
P
------
F
-----
E
---
E
I
-
K
K
Y
--
E
S
--------------
L
I
---
E
--------
E
-
Q
I
P
---
Y
---
A
-----
N
---
Y
-
E
S
-
V
R
N
A
---
V
F
S
L
E
K
R
L
-
A
-
D
L
G
V
D
R
K
--------
S
C
H
I
D
L
V
P
E
N
F
I
E
--
S
--
P
--
Q
------
G
R
L
Y
---------------------
L
I
D
W
E
Y
-
S
S
M
N
D
--
P
M
W
D
L
-
A
-----------
A
-
L
------
F
L
-----
E
------
S
--------
E
-----------------
F
T
----
S
Q
E
E
-
E
T
F
----
L
S
H
Y
------
E
S
D
-
Q
T
------------------------
P
V
S
-
H
E
K
-
I
A
I
Y
K
I
L
Q
---
D
T
I
W
S
L
W
T
---
V
Y
----
K
E
E
Q
GED
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
-----------------------------------------------
29
Fugue
65.97
19%
20
- C4 -
-
2QG7
-
?
A:
[50-458]
YPITESNLRILEGED
R
S
E
K
A
K
E
L
L
K
K
Y
V
S
N
V
-
F
E
N
E
K
-------------------
T
L
Y
-
I
Y
C
K
Y
V
M
L
HYGKDLVNP
N
-------
E
V
D
S
L
E
F
Q
I
I
N
G
T
-
N
-
I
L
I
K
V
K
D
M
--------
S
--------
K
Q
A
K
Y
----
L
I
R
----
L
Y
G
-
P
T
D
--
E
--
I
--
I
N
R
-----
E
R
E
K
----
K
----
I
S
-
C
I
L
Y
N
-
K
N
--
I
A
K
-------
K
I
Y
-----
V
---
F
F
-
T
N
-
G
-
R
I
E
E
F
M
D
G
-----
Y
A
L
-
S
R
E
-
D
I
K
N
P
K
F
Q
K
L
I
A
-
K
N
L
K
L
L
H
D
I
-------
K
L
N
E
N
L
Y
K
E
L
Q
V
T
Q
K
V
P
G
T
------
R
P
---
S
F
---
L
W
-
N
T
I
--
W
K
Y
-
F
---------
H
L
L
N
-
E
E
R
---
K
KI
C
S
F
-
D
A
K
---
A
---
N
I
---
L
K
---
L
-
I
D
-
F
D
V
L
R
D
S
I
V
E
V
E
S
L
C
K
R
-
E
-
N
S
P
I
V
--------
L
C
H
C
D
L
L
S
S
N
I
I
N
--
T
VG
E
--
G
------
D
S
I
S
---------------------
F
I
D
F
E
Y
-
S
C
P
M
E
--
R
A
Y
D
I
-
A
N
H
F
N
E
------
Y
-
A
------
G
F
-----
N
------
C
--------
D
-----------------
W
D
LTPS
K
E
E
E
-
Y
H
F
----
I
M
H
Y
L
GTDD
E
E
L
I
-
N
Q
L
-------------
I
---------
R
E
I
-
Q
P
F
-
Y
I
C
S
H
I
N
W
---
G
L
W
S
L
L
Q
G
---
M
H
----
S
F
D
F
---
I
N
-
Y
G
M
T
R
L
T
A
S
C
L
P
I
F
R
S
K
V
---------------------------------------------
41
HHSearch
64.95
18%
38
- C4 -
-
4R7B
-
?
A:
[18-303]
--------------------------------
G
S
H
M
E
-------------------
K
I
I
-
K
E
K
I
S
S
L
L
SQE------
E
-------
E
V
L
S
V
E
Q
L
-
G
G
M
T
-
N
-
Q
N
Y
L
A
K
T
T
--------
N
---------
K
-
Q
Y
----
I
V
K
----
F
F
--
G
K
G
--
T
--
E
KL
I
N
R
-----
Q
D
E
K
----
Y
----
N
L
-
E
L
L
K
D
-
L
G
--
L
D
V
K
N
Y
L
F
D
--------------
I
-
E
A
-
G
I
K
V
N
E
Y
I
E
S
A
I
T
L
D
S
T
S
--------
I
K
T
K
F
D
K
I
A
-
P
I
L
Q
T
I
H
T
S
-------
A
K
---------
E
L
R
G
E
F
A
P
------
F
-----
E
---
E
I
-
K
K
Y
--
E
S
--------------
L
I
---
E
--------
E
-
Q
I
P
---
Y
---
A
-----
N
---
Y
-
E
S
-
V
R
N
A
---
V
F
S
L
E
K
R
L
-
A
-
D
L
G
V
D
R
K
--------
S
C
H
I
D
L
V
P
E
N
F
I
E
--
S
--
P
--
Q
------
G
R
L
Y
---------------------
L
I
D
W
E
Y
-
S
S
M
N
D
--
P
M
W
D
L
-
A
-----------
A
-
L
------
F
L
-----
E
------
S
--------
E
-----------------
F
T
----
S
Q
E
E
-
E
T
F
----
L
S
H
Y
------
E
S
D
-
Q
T
------------------------
P
V
S
-
H
E
K
-
I
A
I
Y
K
I
L
Q
---
D
T
I
W
S
L
W
T
---
V
Y
----
K
E
E
Q
GED
F
G
D
Y
G
V
N
R
Y
Q
R
A
V
K
G
L
A
S
Y
-----------------------------------------------
52
HHSearch
63.54
17%
24
- C4 -
-
2QG7
-
?
D:
[110-450]
--------------------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
G
-
T
-
N
-
I
L
I
K
V
K
D
M
--------
S
K-------
Q
A
-
K
Y
----
L
I
R
----
L
Y
--
G
P
K
--
T
--
D
---
N
R
-----
E
R
E
K
----
K
----
I
S
-
C
I
L
Y
N
-
K
N
--
I
A
-
K
K
I
Y
V
F
F
T
------------
N
-----
G
R
I
E
E
F
M
D
G
Y
-
A
L
S
R
E
D
------
I
K
N
P
K
F
Q
K
L
I
A
-
K
N
L
K
L
L
H
D
I
-------
K
L
---------
N
E
N
L
Y
K
E
L
QVTQKV
P
G
---
T
R
---
P
S
-
F
L
W
--
N
-
T
-
I
---------
W
K
Y
F
H
L
L
N
---
E
--
E
R
K
K
I
C
S
FDA
K
A--
N
I
---
L
K
---
L
-
I
D
-
F
D
V
L
R
D
S
I
V
E
V
E
S
L
C
-
K
-
R
E
N
S
P
I
V
--------
L
C
H
C
D
L
L
S
S
N
I
I
N
--
T
--
V
G--------
D
S
I
S
---------------------
F
I
D
F
E
Y
-
S
C
P
M
E
--
R
A
Y
D
I
-
A
-----------
N
-
H
------
F
N
E----
Y
------
A
GFNCDWDL
T
-----------------
P
S
----
K
E
E
E
-
Y
H
F
----
I
M
H
Y
------
L
G
T
-
D
D
E
-------------
E
LI-------
N
Q
L
-
I
R
E
-
I
Q
P
F
Y
I
C
S
---
H
I
N
W
G
L
W
S
---
L
L
----
Q
G
M
H
---
S
S
--
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
----------------------------------------------
35
Fugue
63.44
13%
-4
* C4 *
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--------------------------------
T
D
I
T
E
-------------------
D
E
L
-
R
N
F
L
T
Q
Y
D
---------
V
-------
G
S
L
T
S
Y
K
G
I
A
E
N
S
-
N
-
F
L
L
H
T
T
K
D
--------
P
------------
L
----
I
L
T
----
L
Y
--
E
-------
K
--
K
N
D
-----
L
P
F
F
----
L
----
G
L
M
Q
H
L
A
A
-
K
G
--
L
S
C
P
L
P
L
P
R
K
D
G
E
-----
L
---
L
G
-
E
L
-
S
G
R
P
A
A
L
I
S
F
L
-
E
G
M
W
L
R
-
K
P
E
-
A
K
H
C
R
E
V
G
K
A
L
A
-
A
M
-------------------------------
H
L
------
A
S
---
E
G
---
F
E
-
I
K
R
--
P
N
A
-
L
---------
S
V
D
G
-
W
K
V
---
L
--
W
D
K
-
S
E
E
---
R
---
A
D
---
E
V
---
E
-
K
G
-
L
R
E
E
I
R
P
E
I
D
Y
L
A
A
H
-
W
-
P
-
K
D
L
P
A
G-------
V
I
H
A
D
L
F
Q
D
N
V
F
F
--
L
--
G
--
D
------
E
L
S
G
---------------------
L
I
D
F
Y
F
-
A
C
N
D
L
--
L
A
Y
D
V
-
S
-----------
I
-
C
------
L
N
-----
A
WCFEKD
G
--------
A
-----------------
Y
N
----
V
T
K
G
-
K
A
L
----
L
E
G
Y
------
Q
S
V
R
P
L
S
-------------
E
---------
A
E
L
-
E
A
L
-
P
L
L
S
R
G
S
A
---
L
R
F
F
L
T
R
L
---
Y
D
----
W
L
T
T
---
P
A
-
G
A
L
V
V
K
K
D
P
L
E
Y
L
R
K
L
R
F
H
R
T
IANVAEYGLA--------------------------------
53
HHSearch
61.32
17%
13
- C4 -
-
2QG7
-
?
E:
[110-450]
--------------------------------------------------------------------------------------
S
L
E
F
Q
I
I
N
G
-
I
T
-
N
-
I
L
I
K
V
K
D
M
--------
S
K-------
Q
A
-
K
Y
----
L
I
R
----
L
Y
--
G
P
K
--
T
--
D
EI
I
N
R
-----
E
R
E
K
----
K
----
I
S
-
C
I
L
Y
N
-
K
N
--
I
A
-
K
K
I
Y
V
F
F
T
------------
N
-----
G
R
I
E
E
F
M
D
G
Y
-
A
L
S
R
E
D
------
I
K
N
P
K
F
Q
K
L
I
A
-
K
N
L
K
L
L
H
D
I
-------
K
L
---------
N
E
N
L
Y
K
E
L
QVTQKV
P
G
---
T
R
---
P
S
-
F
L
W
--
N
-
T
-
I
---------
W
K
Y
F
H
L
L
N
---
E
--
E
R
K
K
I
C
S
FDA
K
A--
N
I
---
L
K
---
L
-
I
D
-
F
D
V
L
R
D
S
I
V
E
V
E
S
L
C
-
K
-
R
E
N
S
P
I
V
--------
L
C
H
C
D
L
L
S
S
N
I
I
N
--
T
--
V
GG-------
D
S
I
S
---------------------
F
I
D
F
E
Y
-
S
C
P
M
E
--
R
A
Y
D
I
-
A
-----------
N
-
H
------
F
N
E----
Y
------
A
GFNCDWDL
T
-----------------
P
S
----
K
E
E
E
-
Y
H
F
----
I
M
H
Y
------
L
G
T
-
D
D
E
-------------
E
LI-------
N
Q
L
-
I
R
E
-
I
Q
P
F
Y
I
C
S
---
H
I
N
W
G
L
W
S
---
L
L
----
Q
G
M
H
---
S
S
--
D
F
D
F
I
N
Y
G
M
T
R
L
T
A
S
C
----------------------------------------------
51
HHSearch
60.58
16%
25
- C- -
-
3N4U
-
?
A:
[7-282]
--------------------------------------------------------
D
Q
V
-
E
K
A
I
E
Q
L
Y
P--------
D
F------
T
I
N
T
I
E
I
S
G
E
G
N
D
-
C
-
I
A
Y
E
I
-----------
N
---------
R
-
D
F
----
I
F
K
----
F
P
--
K
H
S
--
R
G
-
S
--
T
N
L
-----
F
N
E
V
----
N
----
I
L
-
K
R
I
H
N
K
L
P
--
L
P
I
P
E
V
V
F
T
G
M
P
S
-----
E
---
T
Y
-
Q
M
-
S
F
A
G
F
T
K
I
K
G
V
-
P
L
T
P
L
L
L
N
N
L
P
K
Q
S
Q
N
Q
A
A
K
D
L
A
-
R
F
L
S
E
L
H
S
I
-------
N
I
---------
S
G
F
K
S
N
L
------------------
V
-
L
D
F
--
R
E
K
-
I
---------
N
E
D
N
---
K
---
K
--
I
K
K
-
L
L
S
---
R
----
E
---
L
K
---
G
-
P
Q
-
M
K
K
V
D
D
F
Y
R
D
I
L
E
N
E
-
I
-
Y
F
K
Y
Y
P
C
--------
L
I
H
N
D
F
S
S
D
H
I
L
F
--
D
--
T
EK
N
------
T
I
C
G
---------------------
I
I
D
F
G
D
-
A
A
I
S
D
--
P
D
N
D
F
-
I
-----------
S
-
L
------
M
E
-----
D
------
D
E-------
E
-----------------
Y
G
----
M
E
F
V
-
S
K
I
----
L
N
H
Y
------
K
H
K
-
D
I
P
------------------------
T
V
-
L
E
K
-
Y
R
M
K
E
K
Y
W
---
S
F
E
K
I
I
Y
G
---
K
E
----
Y
------------------------------------------------------------------------
61
SP3
59.73
13%
23
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
------------------------------
A
-
K
M
R
I
S
-------------------
P
E
L
-
K
K
L
I
---------------------
E
K
Y
R
C
V
K
D
T
E
G
M
S
-
P
A
K
V
Y
K
L
V
G
E
--------
N
--------
E
--
N
L
----
Y
L
K
----
M
T
D
S
R
Y
K
--
G
--
T
--
T
Y
D
V
E
R
E
K
D
M
M
L
----
W
----
L
E
-
G
K
L
P
------
V
P
K
V
L
H
F
E
R
H
D
G
W
-----
S
----------
N
L
L
M
S
E
A
D
G
V
-
L
C
S
E
E
Y
-
E
D
E
-
Q
-
S
P
E
K
I
I
E
L
Y
A
-
E
C
I
R
L
F
H
---------
S
I
---------
D
I
S
D
C
P
Y
T
------
N
S
---
L
D
---
S
R
L
A
E
L
--
D
Y
L
-
L
---------
N
N
D
L
-
A
D
V
---
D
--
C
E
N
-
W
E
E
---
D
----------------
T
-
P
F
K
D
P
R
E
L
Y
D
F
L
K
T
E
-
K
-
P
-
E
E
E
L
V
--------
F
S
H
G
D
L
G
D
S
N
I
F
V
--
K
--
D
--
G
------
K
V
S
G
---------------------
F
I
D
L
G
R
-
S
G
R
A
D
--
K
W
Y
D
I
-
A
-----------
F
-
C
-----------------------------------------------------------------------------
V
-
R
S
I
-------------
R
---------
E
D
I
-
G
E
E
-
Q
Y
V
E
L
F
F
D
---
L
L
G
I
K
P
--------------
D
-----------
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
--------------------------------------------
26
Fugue
59.62
13%
6
- C4 -
-
2Q83
5
COTI_BACSU
A:
[11-346]
-----------------------------
L
S
-
A
E
D
A
K
-------------------
K
L
T
-
E
L
A
E
N
V
L
Q
---------
G
-------
W
D
V
Q
A
E
K
I
D
V
I
Q
--
A
-
L
V
W
K
V
H
T
D
--------
S
--------
G
--
A
V
----
C
L
K
----
R
I
--
H
R
P
-----
E
--
K
K
A
-----
L
F
S
I
----
F
----
A
Q
-
D
Y
L
A
K
-
K
G
MN
V
P
G
I
L
P
N
K
K
G
S
L
Y
-----
S
---
K
H
G
S
F
-
L
F
V
V
Y
D
W
I
E
G
R
-
P
----------
F
E
L
T
V
K
Q
D
L
E
F
I
M
K
G
L
A
D
F
H
T
A
S
VG
Y
Q
P
P
N
G
---------
V
P
I
F
T
K
L
G
------
R
W
---
P
N
---
H
Y
-
T
K
R
--
C
K
Q
M
E
---------
T
W
K
L
M
A
E
A
---
E
--
K
E
D
-
P
F
S
---
Q
---
L
Y
---
L
Q
---
E
I
D
G
-
F
I
E
D
G
L
R
I
K
D
R
L
L
Q
S
-
T
-
Y
-
V
P
W
T
E
Q
L
K
K
S
P
N
-
L
C
H
Q
D
Y
G
T
G
N
T
L
L
--
G
--
E
--
N
------
E
Q
I
W
---------------------
V
I
D
L
D
T
-
V
S
F
D
L
--
P
I
R
D
L
-
R
-----------
K
M
I
I
P
L
L
DT
T
G
-----
V
------
W
--------
D
-----------------
D
E
----
T
F
N
V
M
L
N
A
----
Y
E
S
R
------
A
P
L
-
T
E
E
-------------
Q
---------
K
Q
V
M
F
I
D
M
L
F
P
Y
E
L
Y
D
---
V
I
R
E
K
Y
V
R
---
K
S
----
A
L
-
P
---
K
E
-
E
L
E
S
A
F
E
Y
E
R
I
K
A
N
A
L
R
Q
L
I
-------------------------------------------
24
Fugue
58.26
12%
13
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------------------------
S
A
F
T
F
-
Q
T
L
H
P
-------------------
D
T
I
-
M
D
A
L
F
E
H
G
---------
I
-------
R
V
D
S
G
L
T
P
L
N
S
Y
E
-
N
-
R
V
Y
Q
F
Q
D
E
--------
D
--------
R
-
R
R
F
----
V
V
K
----
F
Y
--
R
P
E
RW
T
--
A
--
D
Q
I
-----
L
E
E
H
----
Q
----
F
A
-
L
Q
L
V
N
-
D
E
--
V
P
V
A
A
P
V
A
F
N
G
Q
T
-----
L
---
L
N
-
H
Q
-
G
F
Y
F
A
-
V
F
P
S
V
-
G
G
R
Q
F
E
-
A
D
N
-----
I
D
Q
M
E
A
V
G
-
R
Y
L
G
R
M
H
Q
T
-------
G
----------
R
K
Q
L
F
I
H
R
------
P
T
---
I
G
---
L
N
-
E
Y
L
--
I
E
P
-
R
---------
K
L
F
E
-
D
A
T
---
L
--
I
P
S
------------
G
---
L
K
---
A
-
A
F
-
L
K
A
T
D
E
L
I
A
A
V
T
A
H
W
-
R
-
E
-
D
F
T
V
L
--------
R
L
H
G
D
C
H
A
G
N
I
L
W
--
R
--
D
--
G
------
P
M
F
-----------------------
V
D
L
D
D
-
A
R
N
G
P
--
A
V
Q
D
L
-
W
-----------
M
-
L
------
L
N
G----
D
------
K
--------
A
-----------------
E
Q
----
R
M
Q
L
-
E
T
I
----
I
E
A
Y
------
E
E
F
S
E
F
D
-------------
T
---------
A
E
I
-
G
L
I
-
E
P
L
R
A
M
R
L
---
V
Y
Y
L
A
W
L
M
---
R
R
WAD
P
A
F
P
K
---
N
F
-
P
W
L
T
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
EPPLQLTPMY-----------------------------
31
Fugue
57.82
14%
57
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------G
M
K
E
L
L
S
T
MDLDTDANTI
P
E
L
K
E
R
-
A
H
M
L
C
-------------------
A
R
F
L
G
G
A
W
K
T
V
P
---------
L
-------
E
H
L
R
I
S
R
I
K
G
G
M
S
-
N
-
M
L
F
L
C
R
L
S
--------
E
--------
V
Y
P
P
I
----
R
N
E
PN
K
V
L
L
--
R
V
Y
--
F
--
N
--
P
E
T
-----
E
S
H
L
----
V
----
A
E
-
S
V
I
F
T
-
L
L
--
S
E
R
H
L
----
G
P
K
L
-----
Y
---
G
I
-
F
S
-
G
G
R
L
E
E
Y
I
P
S
R
-
P
----
L
-
S
C
H
-
E
I
S
L
A
H
M
S
T
K
I
A
-
K
R
V
A
K
V
H
Q
L
-------
E
V
---------
P
I
W
K
-
E
P
D
------
Y
L
---
C
E
---
A
L
-
Q
R
W
--
L
K
Q
-
L
---------
T
G
T
V
-
D
A
E
H
R
F
D
--
L
P
E
-
E
C
G
---
V
---
S
S
---
V
N
---
C
-
L
D
-
L
A
R
E
L
E
F
L
R
A
H
I
S
---
L
-
S
-
K
S
P
V
T
--------
F
C
H
N
D
L
Q
E
G
N
I
L
L
--
P
--
K
--
R
------
L
V
L
I
DFEYASYNY
R
A
F
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
I
-
D
E
A
P
F
--
Y
K
I
Q
T
-
E
NFPE
N
D
Q
M
L
E
F
F
-
L
------
N
Y
-----
L
------
R
--------
E
-----------------
Q
G
----
N
T
R
E
-
N
E
L
----
Y
K
K
S
------
E
D
L
-
V
Q
E
-------------
T
---------
L
P
F
-
V
P
V
-
S
H
F
F
W
G
V
W
---
G
L
L
Q
V
E
L
S
---
P
V
----
G
F
G
F
---
A
D
-
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A
-------------------------------------------
42
HHSearch
54.96
15%
-4
- C4 -
-
6EF6
2
?
A:
[27-322]
------------------------------------
D
-------------------
V
T
I
-
A
Q
Q
A
L
T
H
Y
D--------
V
S------
D
N
A
S
L
R
L
L
-
N
L
S
E
-
N
-
A
T
Y
L
V
E
D
G
--------
E
---------
H
-
Q
S
----
I
L
R
----
V
H
--
R
Q
D
--
Y
HQ
P
--
H
E
I
-----
E
S
E
L
----
D
----
W
L
-
A
A
L
R
T
D
S
D
--
V
T
V
P
T
V
V
P
A
R
D
G
R
R
V
V
T
V
D
P
A
D-
V
-
P
R
-
H
V
V
H
F
E
M
V
G
G
A
-
E
P
D
E
E
S
-------
L
T
L
D
D
F
Q
T
L
G
-
R
I
T
A
S
L
H
E
H
-------
S
Q
---------
R
W
T
R
P
A
G
------------
F
----
G
R
-
F
S
W
DW
E
H
C
-
L
---------
G
----
D
T
P
---
R
--
W
G
R
-
W
Q
D
---
A
EGV
G
A
---
S
E
---
T
-
A
L
-
L
T
R
A
Q
D
L
L
H
R
K
L
E
E
Y
-
G
-
S
G
P
D
R
Y
G
--------
L
I
H
A
D
L
R
L
A
N
L
L
V
--
D
--
S
--
S
TPQ---
R
T
I
T
---------------------
V
I
D
F
D
D
-
C
G
F
G
W
--
Y
F
Y
D
F
-
G
-----------
T
-
A
------
V
S
-----
F
------
I
E-------
H
DP---------------
R
L
----
G
E
W
Q
-
E
S
W
----
V
A
G
Y
------
R
S
R
-
R
E
L
-------------
P
---------
A
A
D
-
E
A
M
-
L
P
S
F
V
F
L
R
---
R
L
L
L
L
A
W
M
---
G
S
----
H
T
-----------------------------------------------------------------------
32
Fugue
54.30
12%
14
- C4 -
-
3JR1
3
?
A:
[14-309]
-------------------------
N
L
Y
F
Q
G
M
W
K
S
I
S
-------------------
Q
V
L
-
A
E
Q
F
G
A
Y
Y
---------
F
-------
I
--
K
H
K
E
K
L
Y
S
G
E
M
N
-
E
I
W
L
I
N
D
E
--------
V
--------
Q
T
V
F
V
----
K
I
N
----
E
R
--
S
Y
R
--
S
M
-
F
--
R
A
E
-----
A
D
Q
L
----
A
----
L
L
-
A
K
T
N
S
-
I
N
--
V
P
L
-----
V
Y
G
I
G
-----
N
---
S
Q
-
G
H
-
S
F
L
L
L
E
A
L
N
K
S
-
K
------------
N
K
Q
S
S
F
T
I
F
A
-
E
K
I
A
Q
L
H
Q
I
Q------
G
P
---------
D
K
Y
G
L
D
F
D
------
T
W
---
L
G
P
I
Y
Q
P
-
N
D
W
--
Q
T
S
-
W
---------
A
K
F
F
-
S
E
N
---
R
--
I
G
W
-
Q
L
Q
---
I
---
C
K
---
E
K
---
G
-
L
I
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D
L
I
V
Q
I
V
A
D
T
L
-
S
K
H
-
N
P
K
P
S
--------
I
L
H
G
N
L
W
I
E
N
C
I
Q
--
V
--
D
--
D
------
K
I
F
V
---------------------
C
----
N
-
P
A
C
Y
W
GD
R
E
C
D
I
-
A
-----------
F
-
S
------
S
L
-----
F
------
E
--------
P
-----------------
F
P
----
T
N
F
Y
-
Q
R
Y
----
N
E
I
Y
------
P
L
E
-
E
G
Y
-------------
L
---------
E
R
K
-
L
I
Y
-
Q
L
Y
Y
L
L
N
F
---
S
Y
R
Y
--------------------
Y
N
-
K
K
Q
S
Y
V
S
L
T
Q
K
L
I
N
Q
I
L
H
K
--------------------------------------------