@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K6XNV5_9ALTE: (2019-01-31 )
MTTAKTPEFSNAQVIELLLQQYKLSGQLKKLPGYCDQNLLLNTDDGKQYIVKIANAVEPKLELEMQNAAMAHLTHKQCAVPCAVNNIQGDNISIITDVSKQSFCLRVLTFIPGKFYADANSNTHSRALWTDLGQFIGNIDLALADFQHPGAFRYLDWDLAQGYRVCMSKKHLLNPQQVNLVDKFLSLYQTQTMPVLSQLPQGVIHNDANDYNLLIDDINTPNKISGLIDFGDMVHSHIVNELAIACAYALMGEKSVHEDILSALTSIVAGYHKIRPLLDVELEVLYSLIALRLCTTVCNAALAIQQQPDNEYLLVSVQPAWQLLEQLSAVNSYAVLCQLRLACQLPVDSGQSAAEIINYRKKHLGKTLSLSYQQPLKMVRGQGAYLFNEQGVPYLDMVNNVCHVGHCHPKVVAAGQAQLAKLNTNTRYLHDNIVNYADKLLATMPDKLSVCMLVNSGSEANELAFRLARCFTKSRELLVVDGAYHGNTNACIEASPYKFDGPGGEGAPAYVHKVTLPDPYRGEFLGNNSDAATAYANSVKETIEQLALNNKKPGAFICESLQGVAGQIIMPDGYLTQVYAHVRAAGGVCIADEVQVGFGRVGSHMWAFETQNVIPDIVTLGKPIGNGHPMAAVITTQEIADAFVTGMEYFNTFGGNPVSCAIGIAVLDVIEQEQLQNHALTTGQYFQDQLNKLKQRFELIGDVRGKGLFIGVELVEDRTTKQPATDKTSWLIEHFKQHHILLSTEGPFYNILKIKPPLAFNSGDADKFINVLELGLAVLSH
Atome Classification :
(36 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......--400.--.--..--.....410.......420--...--....430.--......440....-.-...-450.......460.......470...------....480......-------.490..-...--...500........510....---..---------.520.......530.......540.......550.......560....-...570.......580.......590.......600.......610........620.......630.......640--....-....-650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTTAKTPEFS
N
A
Q
V
I
E
L
L
L
Q
Q
Y
K
LSG
Q
L
K
KLPGYCDQN
L
L
LNTDDG
K
Q
Y
I
V
K
I
A
N
AVEP
K
L
E
L
E
M
Q
N
A
A
M
A
H
LTHKQCAVP
C
A
VNNIQGD
N
I
S
I
I
T
DVSK
Q
S
F
C
L
R
V
L
T
FIPG
K
F
Y
ADANSNTH
S
R
A
L
W
T
D
L
G
Q
F
IGNI
D
L
A
L
ADFQHPGA
F
R
YLD
W
D
L
A
Q
G
Y
R
V
C
M
S
K
K
HLL
N
P
Q
Q
V
N
L
V
D
K
F
L
S
L
Y
QTQT
M
P
V
L
S
QL
P
Q
G
V
IHNDAN
D
Y
N
L
L
I
DDINTP
N
K
I
S
G
L
I
D
F
G
D
M
V
H
S
H
I
V
N
E
L
A
I
A
C
A
Y
A
LMGE
K
S
V
H
E
D
I
L
S
A
L
T
S
I
V
A
G
Y
H
KIR
P
L
L
D
V
E
L
E
V
L
Y
S
L
I
A
L
R
L
C
T
T
V
C
N
A
A
L
A
I
QQQPDN
E
Y
L
L
V
SV
Q
P
A
W
Q
L
L
E
Q
L
S
A
V
N
S
Y
A
V
L
C
Q
L
R
L
A
C
QLPVDSGQ
S
A
A
E
I
I
N
Y
R
K
K
HLGKTLS
L
S
Y
QQ
P
L
K
M
VRGQ
G
A
Y
L
FNEQGV
P
Y
L
D
M
V
N--N--V--C--HV--GHCH
P
K
VVAAGQ
A
Q
L
A
KL--NTN--
T
R
Y
L
H
D
N
I
--
V
N
Y
A
D
K
L
L
-
A
TMP-D-K
L
S
-
V
C
M
L
VNSGS
E
A
N
E
L
A
F
R
L
A
R
C
F
TKSR------
E
L
L
V
V
DGAYHGNT-------
N
A
-
C
I
E-ASP--YKFD-GPGGEGA
P
A
Y
V
H
KVTL---PD---------PYRGEFLGNNS
D
A
A
T
A
Y
A
N
S
V
K
E
T
I
E
Q
L
ALNNKK
P
G
A
F
I
C
E
S
L
Q
GVAG-
Q
I
IMPD
G
Y
L
T
Q
V
Y
A
H
V
RAAG
G
V
C
I
A
D
E
V
Q
V
G
F
G
RVGS
H
M
W
A
FET-QNV
I
P
D
I
V
T
LGKPIGNGH
P
M
A
A
V
I
T
T
Q
E
I
A
D
---
A
F
V
T
-
G
M
E
Y
-
F
N
T
FGGN
P
V
S
C
A
I
G
I
A
V
L
D
V
I
E
Q
E
Q
L
Q
NHALTT
G
Q
Y
F
Q
D
Q
L
N
K
L
K
Q
R
F
E
L
I
G
DVRG
K
G
L
F
I
G
V
E
L
VEDRTTKQPAT
D
K
T
S
W
L
I
E
H
F
K
QH
H
I
L
L
STEGP
F
Y
N
I
L
K
IKPPLAFNSG
D
A
D
K
F
I
N
V
L
E
L
G
L
A
V
LSH
148
HHSearch
86.40
41%
-89
- C8 -
-
5G4J
2
?
A:
[19-439]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
-
I
T
T
--
G
L
T
V
-
H
E
---
P
L
G
A
H
V
R
A
L
R
I
---
P
D
---------
V
S
G
I
A
E
V
D
-
V
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
P
-
149
HHSearch
86.38
41%
-90
- C8 -
-
5G4I
3
?
A:
[19-439]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
-
I
T
T
--
G
L
T
V
-
H
E
---
P
L
G
A
H
V
R
A
L
R
I
---
P
D
---------
V
S
G
I
A
E
V
D
-
V
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
P
-
21
Blastp_CBE
79.53
41%
-26
- C8 -
-
5G4J
2
?
B:
[18-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
I
T
T
G
--
L
T
V
H
-
E
P
L
G
----
A
H
V
R
A
L
R
I
---
P
D
VSGIAEVDV
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
----------
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
--
22
Blastp_CBE
78.88
41%
-27
- C8 -
-
5G4I
2
?
B:
[18-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
I
T
T
G
--
L
T
V
H
-
E
P
L
G
----
A
H
V
R
A
L
R
I
---
P
D
VSGIAEVDV
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
----------
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
--
2
PsiBlast_PDB
78.70
41%
-26
- C8 -
-
5G4J
2
?
A:
[18-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
I
T
T
G
--
L
T
V
H
-
E
P
L
G
----
A
H
V
R
A
L
R
I
---
P
D
VSGIAEVD
V
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
----------
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
--
1
PsiBlast_PDB
77.73
41%
-24
- C8 -
-
5G4I
3
?
A:
[18-438]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
A
R
R
Y
A
T
I
G
P
H
S
P
L
F
Y
R
Q
P
L
E
L
V
S
G
S
G
V
W
L
T
D
A
Q
G
K
V
Y
L
D
G
Y
N
--
N
--
V
--
P
--
H
V
--
G
H
A
N
P
A
V
A
D
A
I
Y
Q
Q
L
L
T
V
--
N
L
H
--
T
R
Y
L
N
S
R
V
--
V
E
Y
A
E
A
L
L
-
S
K
F
D
-
G
-
A
L
E
-
R
L
F
L
T
N
S
G
S
E
A
N
E
L
A
L
R
I
A
R
Q
H
T
G
N
T
------
G
V
L
V
S
D
F
S
Y
H
G
N
T
-------
T
S
-
L
A
E
I
T
T
G
--
L
T
V
H
-
E
P
L
G
----
A
H
V
R
A
L
R
I
---
P
D
VSGIAEVD
V
P
V
L
L
E
Q
S
L
A
D
V
D
A
A
I
A
S
L
Q
A
A
G
H
G
V
S
----------
V
F
L
F
D
P
L
F
S
T
E
G
-
L
L
Q
L
P
S
G
Y
I
E
G
V
A
T
R
V
R
A
A
G
G
L
V
I
S
D
E
V
Q
S
G
F
G
R
T
G
S
G
M
W
G
Y
Q
M
-
F
N
V
E
P
E
L
V
T
M
G
K
P
M
G
N
G
H
P
I
G
A
V
V
T
T
A
E
L
L
D
---
E
F
G
R
-
H
N
M
F
-
F
N
T
F
A
G
N
P
V
S
S
A
A
G
L
A
V
L
R
Y
M
D
Q
E
D
L
M
A
K
A
D
Q
L
G
K
Y
I
R
K
R
L
E
N
I
A
Q
R
S
G
N
V
G
S
V
R
G
R
G
L
F
F
G
I
D
I
I
E
S
D
G
S
R
N
P
A
P
A
L
T
K
I
L
I
E
D
M
R
E
R
G
V
L
I
S
R
V
G
P
H
D
N
V
L
K
M
R
P
P
L
V
F
G
R
E
H
A
D
I
L
L
G
Q
L
E
L
S
L
A
S
L
--
29
Blastp_CBE
72.60
31%
6
- C8 -
-
5WYF
2
ILE2E_LACBU
A:
[19-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
26
Blastp_CBE
72.41
31%
7
- C8 -
-
5WYF
4
ILE2E_LACBU
D:
[19-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
YG-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
33
Blastp_CBE
71.98
31%
7
- C8 -
-
4YSN
2
ILE2E_LACBU
A:
[19-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
28
Blastp_CBE
71.91
31%
8
- C8 -
-
5WYF
2
ILE2E_LACBU
B:
[19-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
25
Blastp_CBE
71.79
31%
12
- C8 -
-
5WYA
7
ILE2E_LACBU
B:
[7-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
31
Blastp_CBE
71.76
31%
11
- C8 -
-
4YSN
2
ILE2E_LACBU
C:
[19-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
32
Blastp_CBE
71.38
31%
11
- C8 -
-
4YSN
2
ILE2E_LACBU
B:
[19-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
154
HHSearch
71.26
31%
3
- C8 -
-
4YSN
2
ILE2E_LACBU
D:
[38-446]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
N
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
SA
I
--
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
--
I
H
Y
TP
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
-
G
N
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
-------
Y
G
-
S
Q
T
-
L
S
G
--
S
S
L
N
M
T
R
K
I
G
P
M
L
P
S
V
V
H
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
-
K
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
--
P
A
H
-
L
F
T
T
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
D
A
F
T
A
V
--
30
Blastp_CBE
71.16
31%
8
- C8 -
-
4YSN
2
ILE2E_LACBU
D:
[19-440]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
YG-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
27
Blastp_CBE
71.14
31%
10
- C8 -
-
5WYF
4
ILE2E_LACBU
C:
[19-444]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
YG-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
63
Blastp_CBE
71.05
34%
-5
- C8 -
-
3DXV
2
ACLR_ACHOB
B:
[26-426]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
N
G
R
E
L
I
D
L
S
G
AW
G
--
A
--
A
--
S
L
--
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
--
A
G
A
--
T
I
L
S
A
S
N
A
P
A
V
T
L
A
E
R
L
L
-
A
S
F
P
-
G
-
E
G
T
H
K
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
------
G
V
I
A
F
A
G
A
Y
H
G
C
T
-------
V
G
-
S
M
--------
A
F
S
-
G
H
S
V
Q
A
D
A
A
K
A
D
G
L
I
L
L
P
Y
P
D
---------
P
Y
R
P
Y
---
R
N
D
P
T
G
D
A
I
L
T
L
L
T
E
K
L
A
--
A
V
P
A
G
S
I
G
A
A
F
I
E
P
I
Q
S
D
G
G
-
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
-
R
L
H
C
F
E
H
-
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
L
P
L
S
A
V
I
A
P
A
E
I
L
D
CAS
A
F
A
-------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
R
K
G
R
L
L
R
D
G
L
S
E
L
A
K
R
H
P
L
I
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
P
A
R
A
E
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
Y
V
G
M
N
G
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
S
-
24
Blastp_CBE
71.02
31%
12
- C8 -
-
5WYA
7
ILE2E_LACBU
C:
[7-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
YG-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
19
PsiBlast_PDB
70.94
31%
14
- C8 -
-
5WYA
6
ILE2E_LACBU
A:
[7-428]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
L
I
D
E
E
N
K
Y
Y
A
R
S
A
R
I
N
Y
Y
N
-
L
V
I
D
H
A
H
G
A
T
L
V
D
V
D
G
N
K
Y
I
D
L
L
A
--
S
--
A
--
S
AI
N
V
--
G
H
T
H
E
K
V
V
K
A
I
A
D
Q
A
Q
K
L
IH
Y
T
P
--
A
Y
F
H
H
V
P
G
--
M
E
L
S
E
K
L
A
-
K
I
A
P
G
N
-
S
P
K
-
M
V
S
F
G
N
S
G
S
D
A
N
D
A
I
I
K
F
A
R
A
Y
T
G
R
Q
------
Y
I
V
S
Y
M
G
S
Y
H
G
S
T
Y
G
-----
S
Q
-
T
L
S
-
G
S
S
--
L
N
M
T
-
R
K
I
G
P
M
L
P
S
V
V
H
-
V
P
Y
---
P
D
---------
S
Y
R
T
Y
P
G
E
T
E
H
D
V
S
L
R
Y
F
N
E
F
K
K
P
F
E
S
F
-
L
P
A
D
E
T
A
C
V
L
I
E
P
I
Q
G
D
G
G
-
I
I
K
A
P
E
E
Y
M
Q
L
V
Y
K
F
C
H
E
H
G
I
L
F
A
I
D
E
V
N
Q
G
L
G
R
T
G
K
-
M
W
A
I
Q
Q
F
K
D
I
E
P
D
L
M
S
V
G
K
S
L
A
S
G
M
P
L
S
A
V
I
G
K
K
E
V
M
Q
---
S
L
D
A
-
P
A
H
L
-
F
T
T
-
A
G
N
P
V
C
S
A
A
S
L
A
T
L
D
V
I
E
Y
E
G
L
V
E
K
S
A
T
D
G
A
Y
A
K
Q
R
F
L
E
M
Q
Q
R
H
P
M
I
G
D
V
R
M
W
G
L
N
G
G
I
E
L
V
K
D
P
K
T
K
E
P
D
S
D
A
A
T
K
V
I
Y
Y
A
F
A
H
G
V
V
I
I
T
L
A
G
--
N
I
L
R
F
Q
P
P
L
V
I
P
R
E
Q
L
D
Q
A
L
Q
V
L
D
--------
62
Blastp_CBE
70.71
34%
-5
- C8 -
-
2ZUK
4
ACLR_ACHOB
B:
[39-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
N
G
R
E
L
I
D
L
S
G
AW
G
--
A
--
A
--
S
L
--
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
--
A
G
A
--
T
I
L
S
A
S
N
A
P
A
V
T
L
A
E
R
L
L
-
A
S
F
P
-
G
-
E
G
T
H
K
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
------
G
V
I
A
F
A
G
A
Y
H
G
C
T
-------
V
G
-
S
M
--------
A
F
S
-
G
H
--------
A
D
G
L
I
L
L
P
Y
P
D
---------
P
Y
R
P
Y
---
R
N
D
P
T
G
D
A
I
L
T
L
L
T
E
K
L
A
--
A
V
P
A
G
S
I
G
A
A
F
I
E
P
I
Q
S
D
G
G
-
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
-
R
L
H
C
F
E
H
-
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
L
P
L
S
A
V
I
A
P
A
E
I
L
D
CAS
A
F
A
-------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
R
K
G
R
L
L
R
D
G
L
S
E
L
A
K
R
H
P
L
I
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
P
A
R
A
E
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
Y
V
G
M
N
G
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
S
-
61
Blastp_CBE
70.65
34%
-5
- C8 -
-
3DXW
4
ACLR_ACHOB
B:
[39-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
I
S
G
G
R
G
A
R
L
I
E
E
N
G
R
E
L
I
D
L
S
G
AW
G
--
A
--
A
--
S
L
--
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
--
A
G
A
--
T
I
L
S
A
S
N
A
P
A
V
T
L
A
E
R
L
L
-
A
S
F
P
-
G
-
E
G
T
H
K
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
------
G
V
I
A
F
A
G
A
Y
H
G
C
T
-------
V
G
-
S
M
--------
A
F
S
-
G
H
--------
A
D
G
L
I
L
L
P
Y
P
D
---------
P
Y
R
P
Y
---
R
N
D
P
T
G
D
A
I
L
T
L
L
T
E
K
L
A
--
A
V
P
A
G
S
I
G
A
A
F
I
E
P
I
Q
S
D
G
G
-
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
-
R
L
H
C
F
E
H
-
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
L
P
L
S
A
V
I
A
P
A
E
I
L
D
CAS
A
F
A
-------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
R
K
G
R
L
L
R
D
G
L
S
E
L
A
K
R
H
P
L
I
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
P
A
R
A
E
T
A
K
L
I
Y
R
A
Y
Q
L
G
L
V
V
Y
Y
V
G
M
N
G
N
V
L
E
F
T
P
P
L
T
I
T
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
S
-
59
Blastp_CBE
68.52
33%
-3
- C8 -
-
5M46
6
?
A:
[27-427]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
A
V
A
G
G
Q
G
A
R
L
V
E
E
D
G
R
E
L
I
D
L
S
G
AW
G
--
A
--
A
--
S
L
--
G
Y
G
H
P
A
I
I
E
A
V
S
R
A
A
A
N
P
--
A
G
A
--
S
I
L
S
A
S
N
A
P
A
V
A
L
A
E
R
L
T
-
A
S
F
P
-
G
-
R
G
T
H
K
V
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
T
R
A
T
G
R
T
------
G
V
I
A
F
I
G
A
Y
H
G
C
T
VGSMAFS
G
H
------------
A
D
-
G
---------
L
I
L
L
P
Y
---
P
D
---------
P
Y
R
P
Y
Q
D
D
P
T
G
D
A
V
L
A
L
---
L
K
E
R
L
A
A
V
P
A
G
S
I
A
-
A
A
F
I
-
E
P
I
Q
S
D
G
G
-
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
S
V
V
C
D
E
V
K
V
G
L
A
R
S
G
-
R
L
H
C
F
E
H
-
E
G
F
V
P
D
I
L
V
L
G
K
G
L
G
G
G
L
P
L
S
A
V
I
A
P
A
E
I
L
D
CAS
A
F
A
-------
M
Q
T
L
H
G
N
P
V
C
A
A
A
G
L
A
V
L
E
T
I
E
A
E
N
L
T
T
A
A
E
R
K
G
K
L
L
R
E
G
L
A
R
L
A
E
R
H
E
L
I
G
D
I
R
G
R
G
L
A
C
G
V
E
L
V
R
N
R
Q
S
R
E
P
A
R
A
E
T
A
K
L
I
Y
R
A
Y
E
L
G
L
V
L
Y
Y
V
G
M
N
G
N
V
L
E
M
T
P
P
L
T
M
T
E
D
E
V
R
H
A
V
N
L
L
D
Q
A
F
T
E
L
S
-
80
Blastp_CBE
51.67
31%
1
- C8 -
-
4JEY
9
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
H
V
-
G
-
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
92
Blastp_CBE
51.41
31%
1
- C8 -
-
2PB0
5
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
H
V
-
G
-
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
85
Blastp_CBE
51.31
31%
-3
- C8 -
-
4JEX
8
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
93
Blastp_CBE
51.11
31%
-0
- C8 -
-
2PB0
5
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
83
Blastp_CBE
51.11
31%
0
- C8 -
-
4JEW
8
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
89
Blastp_CBE
51.05
31%
-1
- C8 -
-
4JEZ
6
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
R
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
86
Blastp_CBE
50.85
31%
2
- C8 -
-
4JF1
6
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
H
V
-
G
-
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
84
Blastp_CBE
50.80
31%
-3
- C8 -
-
4JEX
7
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
88
Blastp_CBE
50.74
31%
-1
- C8 -
-
4JEZ
6
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
R
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
82
Blastp_CBE
50.71
31%
3
- C8 -
-
4JEW
9
ARGD_SALTY
B:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
H
V
-
G
-
S
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
87
Blastp_CBE
50.61
31%
1
- C8 -
-
4JF1
6
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
---------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
81
Blastp_CBE
49.84
31%
-0
- C8 -
-
4JEY
8
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
------
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
91
Blastp_CBE
49.53
31%
1
- C8 -
-
2PB2
6
ARGD_SALTY
A:
[44-361]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
--
G
IA
V
--
T
--
A
L
--
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W-
H
T
S
--
N
V
F
T
N
E
P
A
--
L
R
L
G
R
K
L
I
D
A
T
F
A
-
E
-
R
V
----
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
HSPFK
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
-----
T
V
-
S
V
G
-
G
Q
P
--
K
Y
S
D
-
G
F
G
P
K
--
P
A
D
I
I
H
V
P
F
---
N
D
--------------------------
L
H
A
V
K
------
A
V
M
D
D
H
T
C
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
-
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
-
L
F
A
Y
M
H
-
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
---
A
F
------
H
-
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------------------------------------------------------------------
114
Blastp_CBE
40.31
31%
-7
- C8 -
-
2E7U
2
GSA_THET8
A:
[35-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
--
S
--
W
--
G
--
P
L
IL
G
H
A
H
P
K
V
L
A
R
V
R
E
T
L
E
R
---
G
L
T
--
F
G
A
P
S
P
L
E
--
V
A
L
A
K
K
V
K
-
R
A
Y
P
-
F
--
V
D
-
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
Y
T
G
R
P
------
Y
I
V
K
F
R
G
N
Y
H
G
H
A
-------
D
G
L
L
V
E
-
A
G
S
GA
L
T
L
G
-
V
P
S
S
A
G
V
P
E
E
Y
A
K
L
T
L
---
V
L
---------
E
Y
----------------
N
D
P
E
G
L
R
E
V
L
K
R
R
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
-
V
L
V
P
T
E
D
F
L
K
A
L
H
-
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
-
A
F
G
G
A
T
E
L
-
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
---
K
V
A
P
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
-------------------------------------------------------------------------------------------------------------