@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : K9EH06_9ACTO: (2019-01-31 )
MLLKSGEAEHETPHSKIPPDSHGIIPPDLQPKIPSFLSGTSRLDDSRQRPTADLPKRGFEEPIAQEVPESEAVSVPPSLAAWIRAQRGEIIADLSGELCECFVLRIRTEASGDVVAKIPGKFRYPVERELRARPYLEGLINERLAPREVFADSSQAVIVYDFVPGEAASKATAHLSAEKIPRIFRQAGYALARLHQAATRPSNGYEKAQVCRTLARIAEIEDSAFSTLRREHSELLSQAREELGAYQPRDLPLVPSHGDYRADNWIVGEGGELRVIDFGRFGFRPALADFMPLARSEWPKNSLLRDVFLEGYASGGAGHGTIGGIIAEGRGGWWRVSNICDVLGNLWFEVRGASARLQAEDSDKRTAERSSEATRQAHPHAQADLQLDAQAELQAGFTALARALGF
Atome Classification :
(20 SA)
-----------.........10.-.......20........30....----....40.---..-.....50........60.......-.70........80........---90----........100...----------....--------110-------....-..-...--120-..--------------------------------------.---.....130---.........-----------------------140......------.----150-------..----.....--160...------.-...170----...---------..-..180.------.......190.-----..-----.----------...200----.----..------------...--------..210-.......220---------.....--..---.--------.230---------------.----......240...----.---...250.-------..---.....260.......--270....-------------------------------...--280...----....290-....--..----..-.-----------------300-....------.....310......--.320.-..------..----....330.-......340..-------------....-.350.......360...-....370.......380------------.----.---.....----.390.......400....----------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-----------MLLKSGEAEHET-PHSKIPPDSHGIIPPDLQPK
I
P
S
----
F
LSGTSR---LD-DSRQRPTADLPKRGFE
E
P
I
A
Q
EVP-ESEAVSVP
P
S
L
A
A
W
I
R
AQRG
E
---
I
I
----
A
D
L
S
G
E
L
C
E
C
F
V
L
R
----------
I
RTE--------A---------SG
D
V
-
V
A-KIP--GK--FR--------------------------------------Y---
P
V
E
R
E
L
-----RA
R
P
Y
L
E
G
L
-----------------------
I
NERLA
P
R
E
------V----FAD-------SS----
Q
A
V
I
V
--
Y
DFVPG------E-AAS
K
A
T
----AHL---------
S
A
-
E
K
I
P
-
R
------
I
F
R
Q
A
G
Y
A
L
A
R
-----
L
H
-----
Q
----------
A
ATR-P----S----NG------------
Y
E
K
--------
A
Q
V
C
R
-
T
L
A
R
I
A
E
I
-----------
E
D
S
A
F
--
S
T
---
L
--------
R
R
E
H
---------------
S
----
E
L
L
S
Q
A
R
E
E
LGA----Y---QPRDL-P-------LV---PSHGDYRADN
W
I
VGE--GG
E
L
R
V
I
-------------------------------
D
FG--RFGF
R
P
----
A
L
A
D
F
---
M
P
L
A
--RS----EW-P-----------------
K
---
N
S
L
L
------
R
D
V
F
L
E
GYASGGAG--HG--
T
-
I
G
------
G
I
----
I
AEGRGG
W
-
W
R
V
S
N
I
C
D
V
L
G
-------------
N
L
W
F
-
E
VRGAS
A
R
L
QAEDSDK
R
-
T
A
E
RS
S
E
A
T
RQAHPHA-------------Q----A---
D
L
Q
LD----
A
Q
A
E
L
Q
A
G
F
T
A
L
A
R
A
LGF----------
160
Fugue
64.78
14%
-26
- C6 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
--------------------
S
A
F
-
T
F
Q
T
L
H
-----------
P
D
T
I
M
D
----
A
L
F
E
H
G
I
---
R
V
-
D
S
G
L
T
P
L
N
S
Y
-----------------------------------------------------
E
N
R
V
Y
Q
----------
F
Q
D
E
--------
D
---------
R
R
R
F
-
V
V
-
K
F
Y
--
R
P
--
E
R
--------------------------------------
W
---
T
A
D
Q
I
L
-----
E
E
H
Q
F
A
L
Q
L
-----------------------
V
N
D
E
V
P
V
A
A
------
P
----
V
A
F
-------
N
G
----
Q
T
L
L
N
--
H
Q
G
F
Y
F
------
A
-
V
F
P
S
V
G
----
G
R
Q
---------
F
E
-
A
D
N
I
-
D
------
Q
M
E
A
V
G
R
Y
L
G
R
-----
M
H
-----
Q
----------
T
G
R
K
-
Q
----
L
FIHR
P
T
------------
I
G
L
--------
N
E
Y
L
I
-
E
P
R
K
L
F
E
D
-----------
A
T
L
I
P
--
S
G
---
L
--------
K
A
A
F
---------------
L
----
K
A
T
D
E
L
I
A
A
V
T
A
----
H
---
W
R
E
D
F
-
T
-------
V
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
R
----
D
G
P
M
F
V
-------------------------------
D
L
D
--
D
A
R
N
G
P
----
A
V
Q
D
L
---
W
M
L
L
--
N
G
----
D
K
-
A
-----------------
E
---
Q
R
M
Q
------
L
E
T
I
I
E
A
Y
E
E
------------
F
S
------
E
F
----
D
T
A
E
I
G
L
I
-
E
P
L
R
A
M
R
L
V
Y
Y
-------------
L
A
W
L
-
M
R
R
W
A
D
P
A
F
P
K
N
F
P
W
L
T
-
G
E
D
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
-------------
K
----
V
-----
L
Q
E
----
P
P
L
Q
L
T
P
M
Y
-------------------
161
Fugue
63.74
19%
-0
- C1 -
-
5IKK
3
CLR3_SCHPO
A:
[24-650]
L
K
K
S
G
L
C
Y
D
PR
M
R
F
H
A
T
L
S
E
H
P
E
-
D
P
R
R
V
L
R
V
F
E
A
I
K
K
A
G
Y
V
S
N
V
P
S
PSDV
F
L
R
I
P
A
R
E
A
T
L
E
-
E
L
L
Q
V
H
S
Q
E
M
Y
D
K
M
S
H
E
D
L
A
N
L
E
K
-
I
S
D
S
L
Y
Y
N
N
E
S
A
F
C
A
R
L
A
C
G
S
---
A
I
E
T
C
T
A
V
V
T
G
Q
V
K
N
A
F
A
V
V
RPPGHHALFN
N
V
S
V
--------
T
---------
A
R
S
M
-
L
Q
-
R
F
P
--
D
K
--
I
K
R
V
L
I
V
D
WDIHHG
N
G
T
Q
M
A
F
YDDPN
V
L
Y
V
S
L
H
R
Y
ENGRF
Y
---
P
G
T
N
Y
G
-----
C
A
E
N
C
G
E
G
P
GLGRTVNIPWSCAGMG
D
G
D
Y
I
Y
A
F
Q
R
V
V
M
P
V
A
------
Y
----
E
F
D
-------
P
D
----
L
V
I
V
S
CG
F
D
A
A
A
G
DHIGQ
F
L
-
L
T
P
A
A
Y
----
A
H
M
---------
T
Q
-
M
L
M
G
-
L
ADGK
V
F
I
S
L
E
G
G
Y
N
L
D
S
-----
I
S
-----
T
----------
S
A
L
A
-
V
----
A
----
Q
S
L
L
GIPPGRLHTT
Y
A
C
--------
P
Q
A
V
A
-
T
I
N
H
V
T
K
I
-----------
Q
S
Q
Y
W
--
R
C
---
M
--------
R
P
K
H
F
D
A
N
PKDAHVDR
L
H
D
V
----
I
R
T
Y
Q
A
K
K
L
F
E
D
----
W
---
K
I
T
N
M
-
P
I
L
R
DNNQ
V
L
---
C
S
S
N
F
F
Q
K
D
N
L
L
V
I
V
--
H
E
S
P
R
V
L
G
N
G
TSETNVLNLND
S
L
L
V
D
P
V
S
L
Y
V
E
W
A
M
Q
Q
D
W
G
--
L
I
D
I
N
I
P
E
VD
I
L
S
E
V
---
K
E
L
C
--
L
Y
----
V
W
-
D
-----------------
N
YVE
L
S
I
S
------
K
N
I
F
F
I
G
G
--
G
K
A
V
--
H
G
--
L
-
V
N
------------
L
A
S
S
R
N
V
S
-
D
R
V
K
C
M
V
N
F
L
G
TE
P
L
V
G
L
K
T
ASEE
D
L
P
T
-
W
Y
Y
R
H
S
L
V
F
V
S
S
S
N
E
C
W
-
K
K
A
K
R
A
K
R
R
Y
G
R
L
M
Q
S
-------------
E
----
H
---
T
E
T
S
D
----
M
M
E
Q
H
Y
R
A
V
T
Q
Y
L
L
H
L
L
Q
----------
149
HHSearch
59.73
22%
-10
- C6 -
-
3DXQ
-
?
B:
[20-264]
-------------------------------------------------------------------------------------------------------------
T
---
G
P
----
L
E
R
L
G
G
L
-
T
N
L
V
F
R
----------
A
---------------------
G
-
D
L
-
C
L
-
R
I
P
--------------------------------------------------
N
R
A
N
E
A
-----
V
A
A
R
E
A
A
K
A
-------------------------
G
V
-
S
P
E
V
------
L
----
H
V
D
-------
P
A
----
T
G
V
M
V
--
T
R
Y
I
A
G
------
A
Q
T
M
S
P
E
K
-----------------
F
-
K
T
R
P
-
G
------
S
P
A
R
A
G
E
A
F
R
K
-----
L
H
-----
G
----------
S
G
A
V
-
F
----
P
----
F
R
------------
F
E
---------------
L
F
A
M
I
D
D
Y
-----------
L
K
V
L
S
--
T
K
N
V
T
L
--------
P
A
G
Y
---------------
H
----
D
V
V
R
E
A
G
G
V
R
S
A
----
L
---
A
A
H
P
L
-
P
-------
L
A
---
A
C
H
C
D
P
L
C
E
N
F
L
D
T
G
---
E
R
M
W
I
V
-------------------------------
D
W
E
--
Y
S
G
M
N
D
----
P
L
W
D
L
---
G
D
L
S
--
V
E
----
G
--
K
-----------------
F
---
N
A
N
Q
------
D
E
E
L
M
R
A
Y
F
G
G
E
A
R
--
P
A
---------------------
E
R
G
R
V
-
V
I
Y
K
A
M
C
D
L
L
W
-------------
T
L
W
G
-
L
I
Q
L
A
N
D
--------------------------------------------------------------------------------------
151
HHSearch
58.16
16%
-5
- C6 -
-
3C5I
3
?
D:
[36-332]
-------------------------------------------------------------------------------------------------------------
L
---
R
V
----
K
Q
I
L
--
L
-
T
N
Q
L
F
E
----------
V
G
L
K
--------
E
E
T
A
N
N
Y
NSI
R
T
R
V
-
L
F
-
R
I
Y
--
G
K
--
H
V
--------------------------------------
D
ELY
N
T
I
S
E
F
-----
E
V
Y
K
T
M
S
K
Y
-------------------------
K
I
-
A
P
Q
L
------
L
----
N
T
F
-------
N
------
G
G
R
I
--
E
E
W
L
Y
G
------
D
-
P
L
R
I
D
------------------
D
-
L
K
N
P
-
T
------
I
L
I
G
I
A
N
V
L
G
K
-----
F
H
-----
T
----------
L
S
R
K
-
R
----
H
----
L
P
------------
E
H
W
--------
D
R
T
P
C
-
I
F
K
M
M
E
K
W
-----------
K
N
Q
L
F
--
K
Y
---
K
NIEKY---
N
C
D
I
---------------
H
K
Y
I
-
K
E
S
D
K
F
I
K
F
M
K
V
----
Y
S
KS
D
N
L
A
N
-
T
-------
I
V
---
F
C
H
N
D
L
Q
E
N
N
I
I
N
T
N
---
K
C
L
R
L
I
-------------------------------
D
F
E
--
Y
S
G
F
N
F
----
L
A
T
D
I
---
A
N
F
F
--
I
E
----
T
S
-
I
DYSVSSYPF
F
E
I
D
KKKY
I
---
S
Y
E
N
------
R
K
L
F
I
T
A
Y
L
S
N
Y
L
D
KV
V
P
--
T
--
P
------
K
L
----
I
D
E
I
L
E
A
V
-
E
V
Q
A
L
G
A
H
L
L
W
-------------
G
F
W
S
-
I
I
R
G
Y
Q
---------------------------------------------------------------------------------------
162
Fugue
58.01
17%
45
- C6 -
-
4OCV
2
?
A:
[24-378]
---------------
T
N
E
A
L
F
D
V
A
S
H
F
A
L
E
G
T
V
D
S
I
E
P
---------------
Y
G
D
G
H
---
I
N
-
T
T
Y
L
V
T
T
-
D
G
P
R
Y
I
L
Q
R
M
N
T
G
I
F
P
D
T
V
N
L
M
R
N
V
E
L
V
T
S
T
L
K
A
Q
G
K
E
--------------------
T
L
D
----------
I
V
R
T
--------
T
---------
S
G
D
T
-
W
A
-
E
I
D
--
G
G
--
A
W
--------------------------------------
R
---
V
Y
K
F
I
E
-----
H
T
M
S
Y
--
N
L
-----------------------
V
P
N
P
D
V
F
R
E
------
A
----
G
R
A
-------
F
G
----
D
F
Q
N
F
--
L
S
G
F
D
A
------
N
-
Q
L
T
E
T
I
----
A
H
--------------------------
F
H
D
T
P
H
R
F
E
D
-----
F
K
-----
K
----------
A
L
A
A
-
D
----
E
----
L
G
------------
R
A
A
--------
G
----------
C
G
P
-----------
E
I
E
F
Y
--
L
S
---
H
--------
A
D
Q
Y
---------------
A
----
V
V
M
D
G
L
R
D
G
--------------
S
I
-
P
-------
L
R
---
V
T
H
N
D
T
K
L
N
N
I
L
M
D
A
TT
G
K
A
R
A
I
I
-------------------------------
D
L
D
--
T
I
M
P
G
S
----
M
L
F
D
F
---
G
D
S
I
--
R
F
GAST
A
L
-
E
-----------------
D
---
E
R
D
L
------
D
K
V
H
F
----
S
T
E
L
F
--
R
A
--
Y
-
T
E
------
G
F
----
V
G
E
L
R
D
S
I
T
A
R
E
A
E
L
L
P
F
S
G
-------------
N
L
L
T
-
M
E
C
G
M
R
F
L
A
D
Y
L
E
G
D
V
Y
-
F
A
T
K
Y
P
E
-----
H
N
L
V
-------------
R
----
S
---
R
T
Q
I
K
----
L
V
R
E
M
E
Q
R
A
D
E
T
R
A
I
V
A
D
V
M
E
T
T-----
159
Fugue
53.92
15%
21
- C6 -
-
3HAM
3
?
A:
[1-299]
---------------------------------------------------
M
V
N
L
D
A
E
---
I
Y
-
E
H
L
N
K
Q
I
K
I
N
E
L
R
Y
L
S
S
------------------------------------------
G
D
D
S
D
T
F
L
C
---------------------------------
N
E
Q
Y
-
V
V
-
K
V
P
KR
D
S
--
V
R
--------------------------------------
I
---
S
Q
K
R
E
F
-----
E
L
Y
R
F
L
E
N
C
-----------------------
K
L
S
Y
Q
I
P
A
V
------
V
----
Y
---------
Q
S
----
D
R
F
N
I
--
M
K
Y
I
K
G
------
E
-
R
I
T
Y
E
Q
Y
---
H
K
L
---------
S
E
-
K
E
K
D
-
A
------
L
A
Y
D
E
A
T
F
L
K
E
-----
L
H
-----
S
IEIDCSVSLF
S
D
A
L
-
V
----
N
----
K
K
------------
D
K
F
--------
L
Q
D
K
K
-
L
L
I
S
I
L
E
K
-----------
E
Q
L
L
T
--
D
E
---
M
--------
L
E
H
I
---------------
E
----
T
I
Y
E
N
I
L
N
N
A
V
L
----
F
---
K
Y
T
P
C
-
L
-------
V
------
H
N
D
F
S
A
N
N
M
I
F
R
N
--
N
R
L
F
G
V
I
-------------------------------
D
F
G
--
D
F
N
V
G
D
----
P
D
N
D
F
----
L
C
L
--
L
D
----
C
S
-
T
-----------------
D
---
D
F
--------
G
K
E
F
G
R
K
V
L
K
Y
Y
Q
H
--------------------------------------
K
A
P
E
-------------
V
A
E
R
-
K
A
E
L
N
D
V
Y
W
S
I
D
Q
I
I
Y
G
-
Y
E
R
K
D
R
E
M
L
I
K
G
V
S
E
L
-------------
L
--------------------------
Q
T
Q
A
E
M
F
I
F
----------
168
Fugue
53.65
13%
-21
- C6 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
-------------------------------
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
----
G
A
A
P
E
V
T
---
V
E
-
S
G
V
D
S
T
G
M
S
S
E
T
I
I
L
T
A
R
W
Q
Q
--------------------------------------
D
G
R
S
I
Q
Q
K
L
V
----------
A
R
V
A
--------
P
---------
A
A
E
D
-
V
P
-
V
F
P
-------
T
--------------------------------------
Y
---
R
L
D
H
Q
F
-----
E
V
I
R
L
V
G
E
L
-----------------------
T
D
V
P
V
P
R
V
R
------
W
----
I
E
T
-------
T
G
DVLG
T
P
F
F
L
--
M
D
Y
V
E
G
------
V
-
V
P
P
D
V
M
----
P
Y
T
FGDNWFADA
P
A
-
E
R
Q
R
-
Q
------
L
Q
D
A
T
V
A
A
L
A
T
-----
L
H
S
IPN
A
Q
----------
N
T
F
S
-
F
----
L
----
T
D
------------
T
T
L
--------
H
R
H
F
N
-
W
V
R
S
W
Y
D
F
-----------
A
V
E
G
I
--
G
----------------
R
---------------
S
----
P
L
L
E
R
T
F
E
W
L
Q
S
----
H
---
W
P
D
D
A
-
A
A
RE----
P
V
---
L
L
W
G
D
A
R
V
G
N
V
L
Y
R
D
--
F
Q
P
V
A
V
L
-------------------------------
D
W
E
--
M
V
A
L
G
P
----
R
E
L
D
V
---
A
W
M
I
--
F
A
----
H
R
-
V
-----------------
F
---
Q
E
L
A
------
G
L
A
T
L
P
G
-
L
P
E
V
M
R
--
E
D
--
D
-
V
R
------
A
T
----
Y
Q
A
L
T
G
V
---
E
L
G
D
L
--
H
W
F
-------------
Y
V
Y
S
-
G
V
M
W
A
C
V
F
M
R
T
G
A
R
R
V
H
-
F
G
E
I
E
K
P
D
D
V
E
S
L
F
Y
H
-------------
A
----
G
---
L
M
K
H
L
----
L
G
E
E
H
-----------------------
126
SP3
53.14
11%
-4
- C6 -
-
1ND4
1
KKA2_KLEPN
A:
[10-264]
-----------------------------------------------------------------------------
G
S
P
A
A
W
V
E
R
L
F
-
G
Y
D
----------
W
A
Q
Q
T
I
G
C
------------
S
D
A
----
A
V
F
R
----------
L
S
A
Q
--------
G
---------
R
P
V
L
F
V
K
-
T
D
L
--
S
G
--
A
L
--------------------------------------
N
---
E
L
Q
D
E
A
-----
A
R
L
S
W
L
A
T
T
-----------------------
G
V
P
C
A
A
V
L
D
------
V
----
V
T
E
-------
A
G
----
R
D
W
L
L
--
L
G
E
V
P
G
------
Q
-
D
L
--
L
S
----
S
H
L
---------
A
----
P
A
-
E
------
K
V
S
I
M
A
D
A
M
R
R
-----
L
H
-----
T
----------
L
D
P
A
-
T
CPFD
H
----
Q
A
------------
K
H
R
--------
I
E
R
A
R
-
T
R
M
E
A
G
L
V
-----------
D
Q
D
D
L
--
D
E
---
E
--------
H
Q
G
L
---------------
A
------
P
A
E
L
F
A
R
L
K
A
----
R
---
M
P
D
G
E
-
D
-------
L
V
---
V
T
H
G
D
A
C
L
P
N
I
M
V
E
N
--
G
R
F
S
G
F
I
-------------------------------
D
C
G
--
R
L
G
V
A
D
----
R
Y
Q
D
I
---
A
L
A
T
--
R
D
----
I
A
E
E
-----------------
L
---
G
G
E
W
------
A
D
R
F
L
V
L
Y
---
G
I
A
--
A
P
--
D
------------------------
S
Q
R
I
A
F
Y
R
L
L
D
-------------
E
F
F
-----------------------------------------------------------------------------------------------
155
HHSearch
51.81
15%
16
- C6 -
-
1ZYL
-
SRKA_ECOLI
A:
[15-289]
--------------------------------------------------------------------------------------------------
T
I
M
D
A
L
F
E
H
G
I
R
VDS
G
L
----
T
P
L
-
N
S
Y
-
E
N
R
V
Y
Q
----------
F
Q
D
E
--------
D
---------
R
R
R
F
-
V
V
-
K
F
Y
--
R
P
--
E
R
WT
A
-----------------------------------
D
---
Q
I
L
E
E
H
-----
Q
F
A
L
Q
L
V
N
D
-------------------------
E
V
P
V
A
A
P
------
V
----
A
F
N
GQT
L
L
N
H
Q
G
----
F
Y
F
A
V
--
F
P
S
V
G
G
------
R
-
Q
F
E
A
D
----------------------
N
I
-
D
------
Q
M
E
A
V
G
R
Y
L
G
R
-----
M
H
-----
Q
----------
T
G
R
K
-
Q
----
L
----
F
I
------------
H
R
P
---------
T
-
I
G
-
L
N
E
Y
L
I
E
P
-----------
R
K
L
F
E
D
A
T
L
---
I
--------
P
S
G
L
---------------
K
A
A
F
L
K
A
T
D
E
L
I
A
A
V
T
A
----
H
---
W
R
E
D
F
-
T
-------
V
L
---
R
L
H
G
D
C
H
A
G
N
I
L
W
R
D
----
G
P
M
F
V
-------------------------------
D
L
D
--
D
A
R
N
G
P
----
A
V
Q
D
L
---
W
M
L
L
--
N
G
----
D
K
-
A
-----------------
E
---
Q
R
M
Q
------
L
E
T
I
I
E
A
Y
E
E
F
S
E
F
--
D
T
--
A
-
E
-----------------
I
G
L
I
-
E
P
L
R
A
M
R
L
V
Y
Y
-------------
L
A
W
L
-
M
R
R
W
A
D
P
A
-------------------------------------------------------------------------------------
148
HHSearch
51.50
22%
28
- C- -
-
3DXQ
-
?
A:
[20-264]
-------------------------------------------------------------------------------------------------------------
T
---
G
P
----
L
E
R
L
G
G
L
-
T
N
L
V
F
R
----------
A
---------------------
G
-
D
L
-
C
L
-
R
I
P
--
G
K
----Y-------------------------------------
I
---
N
R
A
N
E
A
-----
V
A
A
R
E
A
A
K
A
-------------------------
G
V
-
S
P
E
V
------
L
----
H
V
D
-------
P
A
----
T
G
V
M
V
--
T
R
Y
I
A
G
------
A
Q
T
M
S
P
E
K
-----------------
F
-
K
T
R
P
-
G
------
S
P
A
R
A
G
E
A
F
R
K
-----
L
H
-----
G
----------
S
G
A
V
-
F
----
P
----
F
R
------------
F
E
---------------
L
F
A
M
I
D
D
Y
-----------
L
K
V
L
S
----NVT
L
--------
P
A
G
Y
---------------
H
----
D
V
V
R
E
A
G
G
V
R
S
A
----
L
---
A
A
H
P
L
-
P
-------
L
A
---
A
C
H
C
D
P
L
C
E
N
F
L
D
T
G
---
E
R
M
W
I
V
-------------------------------
D
W
E
--
Y
S
G
M
N
D
----
P
L
W
D
L
---
G
D
L
S
--
V
E
----
G
--
K
-----------------
F
---
N
A
N
Q
------
D
E
E
L
M
R
A
Y
F
G
G
E
A
R
--
P
A
---------------------
E
R
G
R
V
-
V
I
Y
K
A
M
C
D
L
L
W
-------------
T
L
W
G
-
L
I
Q
L
A
N
D
--------------------------------------------------------------------------------------
131
SP3
51.09
10%
9
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
-------------------------------------------
G
M
K
E
----
L
L
---
S
T
---
M
D
L
D
T
D
A
N
T
I
P
E
L
K
-
E
R
A
H
M
L
C
A
R
F
L
G
-
G
A
W
K
-
T
V
P
L
E
H
L
R
I
S
R
I
K
G
G
M
---
S
--------------
N
M
L
F
L
----------
C
R
L
S
--------
E
---------
V
Y
P
P
-
I
R
-
N
E
P
--
N
K
V
L
L
R
--------------------------------------
V
---
Y
F
N
P
E
T
E
S
H
L
V
A
E
S
V
I
F
T
L
L
-----------------------
S
E
R
H
L
G
P
K
L
------
Y
----
G
I
F
-------
S
G
------
G
R
L
--
E
E
Y
I
P
S
------
R
------
P
----
L
S
C
---------
H
E
-
I
S
L
A
-
H
------
M
S
T
K
I
A
K
R
V
A
K
-----
V
H
-----
Q
----------
L
E
V
P
I
W
----
K
----
E
P
------------
D
Y
L
--------
C
E
A
L
Q
-
R
W
L
K
Q
L
T
G
T
V
DAE
H
R
F
D
L
P
E
E
C
G
V
--
S
S
---
V
--------
N
C
L
D
---------------
L
----
A
R
E
L
E
F
L
R
A
H
I
S
----
L
---
S
--
K
S
-
P
-------
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
----
P
K
R
L
V
L
I
-------------------------------
D
F
E
--
Y
A
S
Y
N
Y
--------------------------------------------------
R
A
F
------
D
F
A
N
H
F
I
E
W
T
I
D
Y
D
--
I
D
--
E
-
A
P
------
F
Y
----
K
I
Q
--------
T
E
N
F
P
E
N
D
Q
-------------
M
L
E
F
--
F
L
-
N
Y
L
R
E
Q
G
N
T
R
E
N
E
-
L
Y
K
K
S
E
D
L
V
Q
E
T
L
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
L
Q
----
V
ELS
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A---------
166
Fugue
50.14
15%
17
- C6 -
-
3CSV
11
?
A:
[4-333]
---------------------------------------
S
R
E
D
E
I
R
D
----
F
L
A
T
H
G
Y
---
A
D
-
W
N
R
T
P
R
Y
------------------------------------------------------------
Q
R
----------
L
R
S
P
--------
T
---------
G
A
K
A
-
V
L
M
D
W
S
--
P
E
--
E
G
--------------------------------------
G
---
D
T
Q
P
F
V
-----
D
L
A
Q
Y
L
R
N
-------------------------
L
D
I
S
A
P
E
I
------
Y
----
A
E
E
-------
H
A
----
R
G
L
L
L
--
I
E
D
L
G
D
------
A
-
L
F
T
E
V
I
----
N
N
-----------
D
-
P
A
Q
E
M
P
------
L
Y
R
A
A
V
D
L
L
I
H
-----
L
H
-----
D
----------
A
Q
T
P
-
E
----
L
----
A
R
------------
L
D
P
--------
E
T
L
S
E
M
T
R
L
A
F
S
E
Y
-----------
R
Y
A
I
L
--
G
D
---
A
--------
A
E
D
N
---------------
R
----
K
R
F
E
H
R
F
A
Q
I
L
S
----
A
---
Q
L
E
G
D
M
V
-------
F
V
-----
H
R
D
F
H
A
Q
N
L
L
W
L
P
--
E
R
E
-
G
L
A
-------------------------------
R
V
G
--
V
I
D
F
Q
D
----
A
K
L
--------
G
--
H
R
----
A
Y
-
D
-----------------
L
---
V
S
L
L
------
Q
D
A
R
R
D
---
V
P
A
Q
V
--
E
A
--
Q
M
I
D
------
H
Y
----
I
Q
A
T
G
V
D
E
-
S
H
F
R
S
A
Y
A
V
I
A
-------------
V
Q
R
N
M
R
I
L
G
I
F
A
R
L
S
Q
R
F
G
K
R
H
-
Y
I
E
F
V
P
R
V
W
A
H
F
E
R
G
L
-------------
A
HPAL
A
---
S
A
A
E
E
----
I
L
N
A
L
P
A
P
A
P
E
V
L
E
R
L
R
A
----------
171
Fugue
49.96
15%
24
- C3 -
-
5MNT
-
MATA2_BPQBE
A:
[2-421]
------------
S
P
K
L
P
R
G
L
R
F
G
-
A
D
N
E
I
L
N
D
F
Q
E
L
W
F
P
D
L
----------------
F
---
I
E
-
S
S
D
T
H
P
W
Y
T
L
K
G
R
V
L
N
A
H
L
D
D
R
L
P
-
N
V
G
G
R
Q
V
R
R
T
------
P
H
R
V
T
---
V
P
----
I
A
S
S
G
L
---
R
P
V
T
T
----------
V
Q
Y
D
--------
P
---------
A
A
-
L
-
S
F
-
L
L
N
--
A
R
--
V
D
--------------------------------------
W
---
D
F
G
N
G
D
-----
S
A
N
L
V
I
N
D
F
-----------------------
L
F
R
T
F
A
P
K
E
FDFSNS
L
----
V
P
R
-------
Y
T
----
Q
A
F
S
A
--
F
N
A
K
Y
G
------
T
-
M
I
G
E
G
L
----
E
T
I
---------
K
Y
L
G
L
L
L
-
R
------
R
L
R
E
G
Y
R
A
V
K
R
GD
L
R
A
L
R
-----
R
----------
V
I
Q
S
-
Y
----
H
----
N
G
------------
K
W
K
P
ATAGN
L
W
L
E
F
R
Y
-
G
L
M
P
L
F
Y
D
-----------
I
R
D
V
M
--
L
D
---
W
--------
Q
N
R
H
---------------
D
----
K
I
Q
R
L
L
R
F
S
V
G
H
----
G
---
E
D
Y
V
V
-
E
-------
F
D
NLY
P
A
V
A
Y
F
K
L
K
G
E
I
T
L
E
--
R
R
H
R
H
G
I
-------------------------------
S
Y
A
--
N
R
E
G
Y
A
----
V
F
D
N
G
---
S
L
R
P
--
V
S
----
D
W
-
K
-----------------
E
---
L
A
T
A
FINPHE
V
A
W
E
L
T
P
Y
S
F
V
V
D
W
--
F
L
--
N
-
V
G
------
D
I
----
L
A
Q
Q
G
Q
L
Y
-
H
---
N
I
D
I
V
D
G
-------------
F
D
R
R
-
D
I
R
L
K
S
F
T
I
K
G
E
R
N
G
R
P
V
N
V
S
A
S
L
S
A
V
D
L
F
Y
S
R
L
-------------
H
----
T
---
S
N
L
P
F
----
A
T
L
D
L
D
T
T
F
S
S
F
K
H
V
L
D
S
I
F
L
L
T
Q
R
VKR
129
SP3
47.27
10%
-13
- C6 -
-
1UWH
1
BRAF_HUMAN
A:
[1-276]
-------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
-----
Q
I
T
V
G
Q
---
R
I
----
G
--
S
G
S
F
G
--
T
V
Y
K
----------
G
--
K
--------
W
---------
H
G
D
V
A
V
K
-
M
L
----
N
--
V
T
--------------------------------------
A
---
P
T
P
Q
Q
L
-----
Q
A
F
K
N
E
V
G
V
-----------------------
L
R
K
T
R
H
V
N
I
------
L
LFMG
Y
S
T
-------
A
P
----
Q
L
A
I
V
--
T
Q
W
C
E
G
------
S
-
S
L
Y
H
H
L
HIIE
T
K
F
---------
E
M
-
I
K
L
I
-
D
------
I
A
R
Q
T
A
Q
G
M
D
Y
-----
L
H
-----
A
----------
K
S
---------------------------------------------------------------------------------------------------------------------------------------------------
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
--
D
L
T
V
K
I
G
-------------------------------
D
F
G
LA
T
V
L
S
G
S
-------------------
I
----
L
W
-
M
-----------------
A
---
P
E
V
I
------
R
M
--------
Q
D
K
N
--
P
Y
--
S
-
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
N
I
N
N
R
D
Q
I
I
F
-------------
M
V
G
R
-
G
Y
L
S
P
D
L
S
K
V
R
S
N
C
P
K
A
-
M
K
R
L
M
A
E
C
L
-
K
K
K
R
D
E
-------------
R
----
P
---
L
---------
F
P
Q
I
L
A
S
I
E
L
L
A
R
S
L
P
K
----------
158
Fugue
47.19
16%
9
- C6 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-------------------------------------------------------------------------------------------
A
K
M
R
I
S
P
E
L
K
K
L
I
E
K
Y
R
C
V
---
K
D
----
T
E
G
M
S
P
---
A
K
V
Y
K
----------
L
V
G
E
--------
N
---------
E
N
L
Y
-
L
K
-
M
T
D
--
S
R
--
Y
K
GTT-----------------------------------
Y
---
D
V
E
R
E
K
-----
D
M
M
L
W
L
E
G
K
-----------------------
L
P
-
V
P
K
V
L
H
------
F
----
E
R
H
-------
D
G
----
W
S
N
L
L
--
M
S
E
A
D
G
------
V
-
L
C
S
E
E
------
Y
E
---------
D
E
-
Q
S
P
E
-
K
------
I
I
E
L
Y
A
E
C
I
R
L
-----
F
H
-----
S
----------
I
D
I
S
-
D
----
C
----
P
Y
------------
T
N
S
--------
L
D
S
R
L
-
A
E
L
D
Y
L
L
N
-----------
N
D
L
A
D
--
V
D
---
C
--------
E
N
W
E
---------------
E
----
D
T
P
F
K
D
P
R
E
L
Y
D
----
F
---
L
K
T
E
K
-
P
E
E
E
----
L
V
---
F
S
H
G
D
L
G
D
S
N
I
F
V
K
D
--
G
K
V
S
G
F
I
-------------------------------
D
L
G
--
R
S
G
R
A
D
----
K
W
Y
D
I
A
F
C
V
R
S
I
--
R
E
----
D
I
-
G
-----------------
E
---
E
Q
Y
V
------
E
L
F
F
D
L
L
G
I
K
P
D
W
E
--
K
I
--
K
-
Y
Y
------
I
L
----
L
D
E
L
F
------------------------------------------------------------------------------------------------------------------------------
135
HHSearch
46.72
15%
29
- C6 -
-
4R7B
-
?
A:
[38-281]
-----------------------------------------------------------------------------------------------------------
E
V
L
---
S
V
----
E
Q
L
-
G
G
M
-
T
N
Q
N
Y
L
----------
A
K
T
T
--------
N
---------
K
-
Q
Y
-
I
V
-
K
F
F
--
G
K
--
G
T
--------------------------------------
E
KLI
N
R
Q
D
E
K
-----
Y
N
L
E
L
L
K
D
L
-------------------------
G
L
D
V
K
N
Y
------
L
----
F
-
D
-------
I
E
----
A
G
I
K
V
--
N
E
Y
I
E
S
------
A
I
T
L
D
S
T
---------------------
S
I
K
-
T
------
K
F
D
K
I
A
P
I
L
Q
T
-----
I
H
-----
T
----------
S
A
K
E
-
L
----
R
----
G
E
------------
F
A
---------------
P
F
E
E
I
K
K
Y
-----------
E
S
L
I
E
--
E
Q
---
I
--------
P
Y
A
N
---------------
Y
E
---
S
V
R
N
A
V
F
S
L
E
K
R
----
L
---
A
D
L
G
V
-
D
-------
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
--
Q
G
R
L
Y
L
I
-------------------------------
D
W
E
--
Y
S
S
M
N
D
----
P
M
W
D
L
---
A
A
L
F
--
L
E
----
S
--
E
-----------------
F
---
T
S
Q
E
------
E
E
T
F
L
S
H
Y
E
S
D
Q
T
P
--
V
----------------------
S
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
-------------
S
L
W
T
-
V
Y
K
E
E
Q
---------------------------------------------------------------------------------------
136
HHSearch
46.21
15%
30
- C6 -
-
4R78
2
?
A:
[38-281]
-----------------------------------------------------------------------------------------------------------
E
V
L
---
S
V
----
E
Q
L
-
G
G
M
-
T
N
Q
N
Y
L
----------
A
K
T
T
--------
N
---------
K
-
Q
Y
-
I
V
-
K
F
F
--
G
K
--
G
T
--------------------------------------
E
KLI
N
R
Q
D
E
K
-----
Y
N
L
E
L
L
K
D
L
-------------------------
G
L
D
V
K
N
Y
------
L
----
F
-
D
-------
I
E
----
A
G
I
K
V
--
N
E
Y
I
E
S
------
A
I
T
L
D
S
T
---------------------
S
I
K
-
T
------
K
F
D
K
I
A
P
I
L
Q
T
-----
I
H
-----
T
----------
S
A
K
E
-
L
----
R
----
G
E
------------
F
A
---------------
P
F
E
E
I
K
K
Y
-----------
E
S
L
I
E
--
E
Q
---
I
--------
P
Y
A
N
---------------
Y
E
---
S
V
R
N
A
V
F
S
L
E
K
R
----
L
---
A
D
L
G
V
-
D
-------
R
K
---
S
C
H
I
D
L
V
P
E
N
F
I
E
S
P
--
Q
G
R
L
Y
L
I
-------------------------------
D
W
E
--
Y
S
S
M
N
D
----
P
M
W
D
L
---
A
A
L
F
--
L
E
----
S
--
E
-----------------
F
---
T
S
Q
E
------
E
E
T
F
L
S
H
Y
E
S
D
Q
T
P
--
V
----------------------
S
H
E
K
I
-
A
I
Y
K
I
L
Q
D
T
I
W
-------------
S
L
W
T
-
V
Y
K
E
E
Q
---------------------------------------------------------------------------------------
139
HHSearch
45.77
12%
-25
- C6 -
-
1NW1
-
CKA2_CAEEL
A:
[76-398]
-------------------------------------------------------------------------------------------------------------
L
---
R
I
----
S
R
I
K
G
G
M
-
S
N
M
L
F
L
----------
C
R
L
S
EVYPPIRN
E
---------
P
N
K
V
-
L
L
-
R
V
Y
--
F
N
--
P
E
T
E
------------------------------------
S
---
H
L
V
A
E
S
-----
V
I
F
T
L
L
S
E
R
-------------------------
H
L
G
-
P
K
L
------
Y
----
G
I
F
-------
S
------
G
G
R
L
--
E
E
Y
I
P
S
------
R
-
P
L
S
C
H
------------------
E
-
I
S
L
A
-
H
------
M
S
T
K
I
A
K
R
V
A
K
-----
V
H
-----
Q
----------
L
E
V
P
-
I
----
W
----
K
E
------------
P
D
-------------
Y
-
L
C
E
A
L
Q
R
W
-----------
L
K
Q
L
T
--
G
T
---
V
DAE
H
R
F
D
L
P
E
E
C
---------------
G
VSS-
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
---
S
L
S
K
S
-
P
-------
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
----
R
L
V
L
I
-------------------------------
D
F
E
--
Y
A
S
Y
N
Y
----
R
A
F
D
F
---
A
N
H
F
--
I
E
----
W
T
-
I
DYDIDEAPF
Y
K
I
Q
TENF
P
---
E
N
D
Q
------
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
--
T
R
EN
E
-
L
Y
------
K
K
----
S
E
D
L
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
-------------
G
V
W
G
-
L
L
Q
V
E
L
S
--------------------------------------------------------------------------------------
165
Fugue
45.74
10%
42
- C6 -
-
3I1A
2
?
A:
[3-330]
---------KQ
P
I
Q
A
Q
Q
L
I
E
L
L
K
-
V
H
Y
G
I
D
I
H
T
A
Q
F
I
Q
G
G
-----
A
D
----
T
N
A
F
A
Y
Q
---
A
D
-
S
E
S
K
S
Y
F
I
K
L
K
Y
G
Y
H
D
E
I
N
L
S
I
I
R
-
L
L
H
D
S
G
I
K
E
--------------------------------
I
I
F
----------
P
I
H
T
--------
L
---------
E
A
K
L
-
F
Q
-
Q
L
K
--
H
---
F
K
--------------------------------------
I
---
I
A
Y
P
F
I
-----
H
A
P
N
G
F
T
Q
N
-----------------------
L
T
-----
G
K
------
Q
----
W
K
Q
-------
L
G
----
K
V
L
R
Q
--
I
H
E
T
S
V
------
P
-
I
S
I
Q
Q
Q
----
L
R
K
---------
E
I
-
Y
-------------
S
P
K
W
R
E
I
V
R
-----
S
F
-----
Y
----------
N
Q
I
E
-
F
----
D
----
N
S
------------
D
D
------------------
K
L
T
A
A
-----------
F
K
S
F
F
--
N
Q
---
N
--------
S
A
A
I
---------------
H
----
R
L
V
D
T
S
E
K
L
S
K
K
----
I
---
Q
P
D
L
D
-
K
-------
Y
V
---
L
C
H
S
D
I
H
A
G
N
V
L
V
G
N
--
E
E
S
I
Y
I
I
-------------------------------
D
W
D
--
E
P
M
L
A
P
----
K
E
R
D
L
---
M
F
I
G
GG
V
G
----
N
V
-
W
-----------------
N
---
K
P
H
E
------
I
Q
Y
F
Y
E
G
Y
G
E
I
N
V
---------------------------------------
D
K
T
I
-------------
L
S
Y
Y
-
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
-
S
R
N
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
-------------
K
----
E
---
M
F
D
P
N
----
N
V
V
E
I
A
F
A
T
E
------------------
140
HHSearch
45.08
12%
-25
- C6 -
-
1NW1
-
CKA2_CAEEL
B:
[76-398]
-------------------------------------------------------------------------------------------------------------
L
---
R
I
----
S
R
I
K
G
G
M
-
S
N
M
L
F
L
----------
C
R
L
S
EVYPPIRN
E
---------
P
N
K
V
-
L
L
-
R
V
Y
--
F
N
--
P
E
T
E
------------------------------------
S
---
H
L
V
A
E
S
-----
V
I
F
T
L
L
S
E
R
-------------------------
H
L
G
-
P
K
L
------
Y
----
G
I
F
-------
S
------
G
G
R
L
--
E
E
Y
I
P
S
------
R
-
P
L
S
C
H
------------------
E
-
I
S
L
A
-
H
------
M
S
T
K
I
A
K
R
V
A
K
-----
V
H
-----
Q
----------
L
E
V
P
-
I
----
W
----
K
E
------------
P
D
-------------
Y
-
L
C
E
A
L
Q
R
W
-----------
L
K
Q
L
T
--
G
T
---
V
DAE
H
R
F
D
L
P
E
E
C
---------------
G
VSS-
V
N
C
L
D
L
A
R
E
L
E
F
L
R
A
H
I
---
S
L
S
K
S
-
P
-------
V
T
---
F
C
H
N
D
L
Q
E
G
N
I
L
L
P
K
----
R
L
V
L
I
-------------------------------
D
F
E
--
Y
A
S
Y
N
Y
----
R
A
F
D
F
---
A
N
H
F
--
I
E
----
W
T
-
I
DYDIDEAPF
Y
K
I
Q
TENF
P
---
E
N
D
Q
------
M
L
E
F
F
L
N
Y
L
R
E
Q
G
N
--
T
R
EN
E
-
L
Y
------
K
K
----
S
E
D
L
V
Q
E
T
-
L
P
F
V
P
V
S
H
F
F
W
-------------
G
V
W
G
-
L
L
Q
V
E
L
S
--------------------------------------------------------------------------------------