@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : N1VVK0_9LEPT: (2019-01-31 )
MYPGINETQLELIFSRYGKDCKIEPLQEEASTRRYFRITSVNGKEEVVCADETVNEDFIVISEFLNANGIRVPRIHDTNQNLGLTFMSFEGLKDFSTYNLNDYKNKFPILIDLILKLQSLDPPSLVKTRKFDTEKLSFETNLTLDKFEAFRKQFQIKTDITNEAKAFIEETVGYLNKYPINVFTHRDFHCRNILIAPNTDYALIDFQDARMGVPQYDLASILYDAYYPLPRDFRSLMLKSFRERNVDQTKKFNDTFYLQALQRSFKALGTYFRMVTDHKKDKFKTSIISCLNQLEEIIQLGMFADSLYIFVRSLREELSRHKEFKNL
Atome Classification :
(20 SA)
------------......-------...10.-.....--.---.---------20.-........30------...-.--....40...---------.....50-------...-------.------.----..-..60.-.....-.-.--70.-....------....--------80-----------.-------....--------------....90........100----------.---------.-------.--......110.----......-120.-.-...---.---.-.-130----------.......140..-..------------.....-----150....--.-...160-----....-.....170---..---.----.-..----.-------180-........-190.....--.----.200........210.......220.....------------..----------------230---..------------......240.--....--..250........260.......270.......280.......290..---------.....300.......310.......320.....-----------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------MYPGI
N
-------
E
T
Q
L
E
L
-
I
F
S
RY--G---K---------D-C-KIE
P
L
Q
E
EAS------T
R
R
-
Y
--
F
R
I
TSVNGK---------
E
E
V
V
CA--------DET-------V------N----E
D
-
F
I
V
I
S
-
E
F
LNA-N-G--I-R-VPRI------HDTN--------Q------------N-------L
G
L
T
--------------
F
M
SFEGLKDFSTYNL------------N---------D-------Y--KNK
F
P
I
L
I
D
L
----
I
L
K
L
QS-LD-
P
-
P
-
S
L
V
---
K
---T-R-KFD----------TE
K
L
S
FET--NL-
T
L
------------
D
K
F
E
A
-----
F
-
R
K
Q
F
Q
--I-KTDI-------
T
N
E
A
-
K
A
F
I
E
E
T
V
---
G
Y
---
L
----N-KY----P-------
I
N
--
V
F
THRDFH-C
R
N
I
L
IAP--N----T
D
-
Y
A
L
I
D
F
Q
D
ARMGV
P
Q
Y
D
L
A
S
I
L
Y
D
AYY------------PL----------------
P
-
R
---
D
F
------------
R
S
L
M
L
K
S
F
R
E
--RNV
D
--
Q
T
K-KFN
D
T
F
Y
L
Q
A
L
Q
R
S
F
K
A
L
G
T
Y
F
R
M
V
TDHK
K
D
K
F
K
T
S
I
I
S
C
L
N
Q
L
---------
E
E
I
I
Q
L
G
M
F
A
D
S
L
Y
I
F
V
R
S
L
R
E
E
L
S
R
H
K
E
FKNL-----------------
42
HHSearch
83.81
24%
-7
- C4 -
-
3CSV
11
?
A:
[6-322]
-------------------------
E
D
E
I
R
D
-
F
L
A
T
H
--
G
Y--
A
---------
D
-
W
-
N
R
T
P
--------------
R
-
Y
--
Q
R
L
R
S
P
T
G
A
---------
K
A
V
L
M
D
--------
W
S
P
EEGG---
D
------
T
----
Q
P
-
F
V
D
L
A
-
Q
Y
L
R
N
-
L
-
D
--
I
-
S
-
A
P
E
I
------
Y
A
E
E
--------
H
------------
A
-------
R
G
L
L
--------------
L
I
E
D
L
G
D
A
L
F
T
E
V
I
N
------------
N
---------
D
PAQ----
E
--
M
P
L
Y
R
A
A
V
D
L
----
L
I
H
L
H
D
-
A
Q
T
P
-
E
-
L
A
------------
R
L
D
----------
P
E
T
L
S
E
M
T
--
R
L
A
F
S
------------
E
Y
R
Y
A
-----
I
----
L
G
--
D
-
A
A
E
D
-------
N
R
K
R
F
E
H
R
F
A
Q
I
L
---
S
A
---
Q
----
L
-
E
G
----
D
-------
M
---
V
F
V
H
R
D
F
H
-
A
Q
N
L
L
W
L
P
--
E
REGL
A
R
-
V
G
V
I
D
F
Q
D
A
K
L
G
H
R
A
Y
D
L
V
S
L
L
Q
D
A
R
R
------------
D
V
----------------
P
-
A
---
Q
V
------------
E
A
Q
M
I
D
H
Y
I
Q
--
A
T
G
V
--
D
E
S
-
H
F
R
S
A
Y
A
V
I
A
V
Q
R
N
M
R
I
L
G
I
F
A
R
L
S
Q
R
F
G
K
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H
Y
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F
V
P
R
V
W
A
H
F
---------
E
R
G
L
A
H
P
A
----
L
A
S
A
A
E
E
I
L
N
A
L
P
A
------------------------
53
HHSearch
56.66
17%
1
- C4 -
-
3I1A
4
?
B:
[5-293]
---------------
P
I
Q
-------
A
Q
Q
L
I
E
L
L
K
V
H
Y
--
G
I--
D
---------
I
-
H
-
T
A
Q
F
I
Q
G
G
A
D
------
T
N
A
F
A
--
Y
Q
A
D
S
E
-
S
K
---------
S
Y
F
I
K
L
--------
K
Y
G
Y------
H
------
D
----
E
I
-
N
L
S
I
I
-
R
L
L
H
D
-
S
-
G
--
I
-
K
E
I
I
F
P
------
I
H
T
L
--------
E
AKL
F
Q
Q
L
K----
H
-------
F
K
I
I
--------------
A
Y
P
F
I
H
A
P
N
G
F
T
Q
N
L
------------------------------
T
--
G
K
Q
W
K
Q
L
G
K
V
----
L
R
Q
I
H
E
-
T
S
V
P
-
I
-
S
I
Q
---
Q
Q
LR
K
-
E
-
I
Y
S
----------
P
-
K
W
R
E
I
V
--
R
S
-
F
Y
------------
N
Q
I
E
F
DNSDD
K
L
T
A
A
F
K
--
S
-
F
F
N
Q
N
S
A
----
A
I
H
R
L
V
D
T
S
E
K
L
S
---
K
K
---
I
----
Q
P
D
L
----
D
-------
K
Y
--
V
L
C
H
S
D
I
H
-
A
G
N
V
L
V
G
N
--
E
----
E
S
-
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
G
G
V
G
N
------------
V
W
----------------
N
K
P
---
H
E
------------
I
Q
Y
F
Y
E
G
Y
G
E
--
I
N
V
---
D
-
K
----
T
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
---------------------------------------------------------------------------------
32
Fugue
55.12
12%
22
- C4 -
-
3I1A
2
?
A:
[3-330]
------------
K
Q
P
I
Q
A
-------
Q
Q
L
I
E
L
-
L
K
V
H
Y
--
G
---
I
---------
D
-
I
H
T
A
Q
F
I
Q
G
G
A
D
T-----
N
A
F
-
A
--
Y
Q
A
D
S
E
S
K
S
---------
Y
F
I
K
L
K
--------
Y
G
Y
-------
H
------
D
----
E
I
-
N
L
S
I
I
-
R
L
L
H
D
-
S
-
G
--
I
K
E
-
I
I
F
P
IHTLEA
K
L
F
Q
--------
Q
------------
L
-------
K
H
F
K
--------------
I
I
A
Y
P
F
I
H
A
P
N
G
F
T
Q
------------
N
---------
L
-------
T
--
G
K
Q
W
K
Q
L
G
K
V
----
L
R
Q
I
H
E
-
T
S
-
V
-
P
-
I
S
I
---
Q
---
Q
-
Q
L
R
K
E
----------
I
Y
S
P
K
W
R
E
--
I
V
-
R
S
F
Y
NQIEFDNSDD
K
L
T
A
A
-----
F
-
K
S
F
F
N
Q
-
N
-
S
A
A
I
-------
H
R
L
V
-
D
T
S
E
K
L
S
K
---
K
I
---
Q
----
P
-
D
L
----
D
-------
K
Y
--
V
L
C
H
S
D
I
H
-
A
G
N
V
L
V
G
N
--
E
----
E
S
-
I
Y
I
I
D
W
D
E
P
M
L
A
P
K
E
R
D
L
M
F
I
G
G
G
V
G
N
------------
V
W
N---------------
K
-
P
---
H
E
------------
I
Q
Y
F
Y
E
G
Y
G
E
--
I
N
V
D
---
K
T
-
I
L
S
Y
Y
R
H
E
R
I
V
E
D
I
A
V
Y
G
Q
D
L
L
S
R
N
Q
N
N
Q
S
R
L
E
S
F
K
Y
F
K
E
M
F
D
P
---------
N
N
V
V
E
I
A
F
A
T
E
---------------------------------------
33
Fugue
54.63
13%
19
- C4 -
-
3ATS
1
Y3168_MYCTU
A:
[1-357]
T
L
P
A
V
I
S
R
W
L
S
S
V
L
P
G
G
A
-------
A
P
E
V
T
V
-
E
S
G
V
D
ST
G
---
M
---------
S
-
S
-
E
T
I
I
L
T
A
R
W
Q
Q
DG
R
S
I
Q
Q
K
-
L
--
V
A
R
V
A
P
A
A
E
---------
D
V
P
V
F
P
--------
T
Y
R
-------
L
------
D
----
H
Q
-
F
E
V
I
R
-
L
V
G
E
L
-
T
-
D
--
V
-
P
-
V
P
R
V
------
R
W
I
E
--------
T
------------
T
GDV----
L
G
T
P
--------------
F
F
L
M
D
Y
V
E
G
V
V
P
P
D
V
------------
M
---------
P
-------
Y
--
T
F
G
D
N
W
F
A
D
A
P
A
E
R
Q
R
Q
L
Q
D
-
A
T
-
V
-
A
-
A
L
A
---
T
---
L
-
H
-
S
I
P
----------
N
A
Q
N
T
F
S
F
LT
D
T
-
T
L
------------
H
R
H
F
N
-----
W
-
V
R
S
W
Y
--
D
-
F
A
V
E
-------
G
I
G
R
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S
P
L
L
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T
F
---
E
W
---
L
----
Q
-
S
H
----
W
P
D
D
A
A
A
R
E
P
--
V
L
L
W
G
D
A
R
-
V
G
N
V
L
Y
R
D
--
F
----
Q
P
-
V
A
V
L
D
W
E
M
V
A
L
G
P
R
E
L
D
V
A
W
M
I
F
A
H
R
V
------------
F
Q
----------------
E
-
L
---
A
G
L
A
TLPGLPEVMR
E
D
D
V
R
A
T
Y
Q
A
--
L
T
G
V
--
E
L
G
-
D
L
H
W
F
Y
V
Y
S
G
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C
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F
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G
A
R
R
V
H
F
G
E
I
E
K
P
D
D
---------------------------
V
E
S
L
F
Y
H
A
G
L
M
K
H
L
L
G
E
E
H
----------------------
40
Fugue
51.69
20%
8
* C2 *
-
5HEA
-
?
A:
[4-295]
-------------------------
G
E
L
I
S
I
-
I
V
P
V
Y
--
N
---
V
---------
E
-
K
-
Y
L
K
R
C
L
D
S
L
L
------
R
Q
T
-
Y
KN
F
E
I
I
L
I
N
-------------------------
D
G
S
-------
T
------
D
----
N
S
-
S
I
I
C
E
-
E
Y
A
K
I
-
D
-
N
----
R
-
I
Q
I
L
------
H
Q
T
N
AG
P
S
A
A
--
R
------------
N
-------
A
G
I
T
--------------
Y
A
S
---
G
K
Y
I
T
F
V
D
S
------------
D
---------
D
-------
F
--
V
E
E
F
-
Y
L
E
H
L
----
Y
R
A
L
V
D
-
N
G
-
S
D
I
-
S
V
C
---
N
---
F
-
N
-
S
F
N
----------
E
D
R
Q
S
F
L
F
--
S
I
-
T
K
------------
E
K
Y
-------
F
-
C
K
N
Y
T
--
I
-
A
E
W
M
-------
D
L
N
L
-
F
L
T
F
T
F
S
----------------------
P
-------
T
K
--
L
F
K
A
E
L
F
E
G
I
R
F
P
L
G
R
L
--
R
----
E
D
-
D
A
T
I
----
Y
R
L
Y
L
K
A
S
Q
I
T
F
I
N
E
G
S
Y
Y
------------
Y
S
----------------
Q
-
R
---
D
D
------------
I
S
S
M
I
S
N
A
E
E
--
R
I
A
L
--
L
A
S
-
M
G
Y
D
L
---------------------
T
E
Q
I
K
S
Y
K
G
R
L
K
K
C
C
E
D
A
---------
L
R
--------
N
G
Q
I
E
L
Y
Q
Q
C
C
N
K
L
D
L
I
E
N
Y
P
K
E
-----------------
64
SP3
50.88
11%
8
- C4 -
-
1NW1
-
CKA2_CAEEL
A:
[32-426]
----G
M
K
E
L
L
S
T
M
D
L
D
T
D
ANTI
P
E
L
K
E
R
A
H
M
-
L
C
A
R
F
--
L
---
G
GAWKTVPLE
H
-
L
-
R
I
S
R
I
K
G
G
M
S
------
N
-
M
-
L
--
F
L
C
R
L
S
E
V
Y
PPIRNEPN
K
V
L
L
R
V
Y
--------
F
N
P
-------
E
------
T
E
S
H
L
V
A
-
E
S
V
I
F
-
T
L
L
S
E
-
R
-
H
--
L
---
G
P
K
L
------
Y
G
I
F
-----------------------------
S
G
G
R
--------------
L
E
E
Y
I
P
S
R
P
---
L
S
C
------------
H
---------
E
-------
I
S
L
A
H
M
S
T
K
I
A
K
R
----
V
A
K
V
H
Q
-
L
E
-
V
-
P
--
I
W
---
K
---
E
-
P
-
D
Y
L
----------
C
E
A
L
Q
R
W
L
--
K
Q
-
L
T
------------
G
-
T
V
D
-----
A
-
E
H
R
F
D
--
L
-
P
E
E
C
GVSSVN-
C
L
D
L
-
A
R
E
L
E
F
L
R
---
A
H
---
I
----
S
-
L
S
----
K
S------
P
V
--
T
F
C
H
N
D
L
Q
-
E
G
N
I
L
L
P
K
--
R
----
L
V
---
L
I
D
F
E
Y
A
S
Y
N
Y
R
A
F
D
F
A
N
H
F
I
E
W
T
I
------------
D
Y
DIDEAPF
Y
K
I
Q
TENFP
E
-
N
---
D
Q
------------
M
L
E
F
F
L
N
Y
L
R
--
E
Q
G
N
T-
R
E
N
-
E
L
Y
K
K
S
E
D
L
V
Q
E
T
L
---------------
P
F
V
P
V
S
H
F
F
W
G
V
W
G
L
---------
L
Q
V
E
L
S
P
V
G
F
G
F
A
D
Y
G
R
D
R
L
S
L
Y
F
K
H
K
Q
L
L
K
N
L
A----------------
39
Fugue
50.59
17%
3
- C2 -
-
5TZJ
1
?
A:
[1-349]
------------
M
--------------
K
F
S
V
-
I
V
P
T
Y
--
N
---
S
---------
E
-
K
-
Y
I
T
E
L
L
N
S
L
A
------
K
Q
D
-
F
--
P
K
----
T
E
F
---------
E
V
V
V
V
D
--------
D
C
S
-------
T
------
D
----
Q
T
-
L
Q
I
V
E
-
K
Y
R
N
K
-
L
-
N
--
L
-
K
-
V
S
Q
L
------
E
T
N
S
GGP
G
K
P
--
R
------------
N
-------
V
A
L
K
Q
AEGE
F
V
L
F
V
D
SD
D
Y
I
N
K
E
T
L
K
D
A
A
A
F
I
D
------------
E
---------
H
-------
H
--
S
D
--
V
L
L
I
K
M
----
K
G
V
N
G
R
-
G
V
-
P
-
Q
-
S
M
F
---
K
---
E
-
T
-
A
P
E
----------
V
T
L
L
N
S
R
I
--
I
Y
-
T
L
------------
S
P
T
K
I
-----
Y
-
R
T
A
L
L
--
K
-
D
N
D
I
YFPEELK
S
A
E
D
-
Q
L
F
T
M
K
-----
A
Y
---
L
----
N
-
A
N
----
R
-------
I
S
--
V
L
S
D
K
A
Y
Y
-
Y
A
T
K
R
E
G
E
--
H
----
M
S
-
S
A
Y
V
S
--
P
E
D
F
Y
E
V
M
R
L
I
A
V
E
I
L
N
A
--------------
D
L
----------------
E
-
E
---
A
H
------------
K
D
Q
I
L
A
E
F
L
N
--
R
H
F
S
FS
R
T
N
-
G
F
S
L
K
V
K
L
E
E
Q
P
Q
W
I
N
A
L
G
D
F
I
Q
A
V
P
E
R
V
D
A
L
V
M
S
K
L
R
P
L
L
H
Y
A
---------
R
A
-----
K
D
I
D
N
Y
R
T
V
E
E
S
Y
R
Q
G
Q
Y
Y
R
F
D
I
V
D
G
KLNIQFNEG
E
P
Y
F
E
GID
27
Fugue
48.93
11%
46
- C4 -
-
2OLC
4
MTNK_BACSU
A:
[5-396]
---------KTP
L
Y
E
T
L
N
-------
E
S
S
A
V
A
-
L
A
V
K
L
--
G
---
L
---------
T
-
L
-
T
C
Q
E
I
----
G
------
D
G
N
-
L
--
N
Y
V
F
H
I
Y
D
R
---------
A
L
I
I
K
Q
A
V
PYWPLT
I
D
R
-------
A
------
R
----
I
E
-
S
S
A
L
I
-
R
Q
G
E
H
-
V
-
P
--
H
-
L
-
V
P
R
V
------
F
Y
S
D
--------
T
------------
E
-------
M
A
V
T
--------------
V
M
E
D
L
S
H
L
K
I
A
R
K
G
L
------------
I
---------
E
GENYPH
L
S
--
Q
H
I
G
E
F
L
G
K
T
----
L
F
Y
S
S
D
-
Y
A
-
L
-
E
-
P
K
V
---
K
---
K
-
Q
-
L
V
K
Q
F
TN
P
E
L
C
D
I
T
E
R
L
V
F
T
D
--
P
F
-
F
D
------------
H
D
T
N
D
-----
F
-
E
E
E
L
R
--
P
-
F
V
E
K
-------
L
W
N
N
-
D
S
V
K
I
E
A
A
---
K
L
---
K
----
K
-
S
F
----
L
-------
T
S
AE
T
L
I
H
G
D
L
H
-
T
G
S
I
F
A
S
E
--
H
-----
E
-
T
K
V
I
D
P
E
F
A
F
Y
G
P
I
G
F
D
V
G
Q
F
I
A
N
L
F
L
------------
N
A
----------------
L
-
S
R
DG
A
D
------------
R
E
P
L
Y
E
H
V
N
Q
--
V
W
E
T
--
F
E
E
-
T
F
S
E
A
W
Q
K
D
S
L
D
V
Y
A
N
I
D
G
Y
L
T
D
T
L
S
H
I
F
E
E
A
I
G
F
A
G
C
E
L
I
R
R
T
IGLAHV
A
D
L
D
T
I
V
P
F
D
K
R
I
G
R
K
R
L
A
L
E
T
G
T
A
F
I
E
K
R
S
E
F
K
T
I
T
D
V
I
E
L
F
K
L
L
V
K-----
58
HHSearch
48.14
13%
25
- C4 -
-
5IWU
2
?
A:
[3-261]
----------------
K
D
-------
I
K
Q
V
I
E
-
I
A
K
K
H
--
N
LFL
K
---------
E
-
E
-
T
I
Q
F
N
E
S
G
L
D
------
F
-
Q
-
A
--
V
F
A
Q
D
N
N
G
I
---------
D
W
V
L
R
L
--------
P
R
R
ED
V
M
P
--
R
------
T
----
K
V
-
E
K
Q
A
L
-
D
L
V
N
K
-
Y
-
A
IS
F
-
Q
-
A
P
N
W
------
I
I
Y
----------------------
T
-------
E
E
L
I
--------------
A
Y
K
K
L
D
G
V
P
A
G
T
I
D
H
NIGNYIWEIDIN
N
---------
V
-------
P
--
E
L
F
H
K
S
L
G
R
V
----
L
A
E
L
H
S
-
I
P
S
N
-
K
-
A
A
A
L--
D
---
L
-
V
-
V
H
T
----------
P
E
E
A
---
R
--
M
S
-
M
K
------------
Q
R
M
D
A
-----
V
-
R
A
K
F
G
-----
V
G
E
-------
N
L
---
W
N
R
W
Q
A
W
L
---
N
D
D--
D
M---
W
-
P
K
----
K
-------
T
---
G
L
I
H
G
D
V
H
-
A
G
H
T
M
I
D
K
--
D
----
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
----------------
F
----------------
G
-
E
---
E
G
------------
L
E
A
L
I
L
A
Y
K
E
--
I
G
G
Y
--
Y
W
P
-
K
------------------------------------------------------------------------------------------------------
34
Fugue
47.77
13%
-2
- C4 -
-
1J7L
1
KKA3_ENTFL
A:
[2-264]
-----------------
A
-------
K
M
R
I
S
P
-
E
L
K
K
L
--
I
---
E
---------
K
-
Y
-
R
C
V
K
D
T
E
G
M
S
------
P
A
K
-
V
--
Y
K
L
V
G
E
N
E
N
---------
L
Y
L
K
M
T
--------
D
S
R
YKGTTYD
V
------
E
----
R
E
-
K
D
M
M
L
-
W
L
--
E
-
G
-
K
--
L
-
P
-
V
P
K
V
------
L
H
F
E
--------
R
------------
H
-------
D
G
W
S
--------------
N
L
L
M
S
E
A
D
G
V
L
C
S
E
E
Y
EDE--------
Q
---------
S
-------
P
--
E
K
I
I
E
L
Y
A
E
C
----
I
R
L
F
H
S
-
I
D
-
I
-
S
-
D
C
P
---
Y
---
T
-
N
-
S
L
D
----------
S
R
L
A
E
L
D
Y
--
L
L
-
N
N
------------
D
L
A
D
V
-----
D
-
C
E
N
W
E
-----
E
D
T
-------
P
F
K
D
-
P
R
E
L
Y
D
F
L
---
K
T
---
E
----
K
-
P
E
----
E
-------
E
L
--
V
F
S
H
G
D
L
G
-
D
S
N
I
F
V
K
D
--
G
----
K
V
-
S
G
F
I
D
L
G
R
S
G
R
A
D
K
W
Y
D
I
A
F
C
V
R
S
I
R
E
------------
D
I
----------------
G
-
E
---
E
-------------------------------------------
Q
Y
V
E
L
F
F
D
L
L
G
I
---------------------
K
P
D
---------
W
E
K
I
K
Y
Y
I
L
L
D
E
L
F
------------------------------------
30
Fugue
46.90
12%
-27
* C4 *
-
2PPQ
-
KHSE_AGRFC
A:
[5-320]
--------------
T
D
I
T
-------
E
D
E
L
R
N
-
F
L
T
Q
Y
--
D
---
V
---------
G
-
S
-
L
T
S
Y
K
G
I
--
A
------
E
N
S
-
N
--
F
L
L
H
T
T
K
D
P
---------
L
I
L
T
L
Y
--------
E
K
K
-------
N
------
D
----
L
P
-
F
F
L
G
L
M
Q
H
L
A
A
-
K
-
G
--
L
-
S
-
C
P
L
P
------
L
P
R
K
--------
D
------------
G
-------
E
L
L
G
--------------
E
L
S
G
R
P
A
A
L
I
S
F
L
E
G
M
-----------
W
---------
L
-------
R
--
K
P
E
A
K
H
C
R
E
V
----
G
K
A
L
A
A
M
H
L
-
A
S
E
-
G
F
E
---
I
---
K
-
R
-
P
N
A
----------
L
S
V
D
G
W
K
V
--
L
W
-
D
K
------------
S
E
E
R
A
-----
D
-
E
V
E
K
G
--
L
-
R
E
E
I
-------
R
P
E
I
-
D
Y
L
A
A
H
W
P
---
K
D
---
L
----
P
-
A
G
----
V
-------
I
------
H
A
D
L
F
-
Q
D
N
V
F
F
L
G
--
D
----
E
L
-
S
G
L
I
D
F
Y
F
A
C
N
D
L
L
A
Y
D
V
S
I
C
L
N
A
W
C
F
------------
E
K
----------------
D
-
G
---
A
Y
------------
N
V
T
K
G
K
A
L
L
E
--
G
Y
Q
S
--
V
R
P
L
S
E
A
E
L
E
A
L
P
L
L
S
R
G
S
A
L
R
F
F
L
T
R
L
Y
D
W
L
T
T
P
A
G
A
L
V
V
K
K
D
P
L
E
Y
---------
L
R
K
L
R
F
H
R
T
I
A
N
V
A
E
Y
G
L
A
-------------------------------
50
HHSearch
45.83
13%
15
- C4 -
-
5UXD
2
?
A:
[5-257]
----------------
E
D
-------
L
D
A
L
L
D
-
L
A
A
R
H
--
G
L--
D
LD-------
G
-
G
-
T
L
R
T
E
E
I
G
L
D
------
F
-
R
-
V
--
A
F
A
R
A
H
D
G
G
---------
D
W
V
L
R
L
--------
P
R
R
PDV
L
E
--
R
------
A
----
A
V
-
E
G
R
L
L
-
A
M
L
A
P
H
L
-
D
--
V
-
A
-
V
P
D
W
------
R
I
S
----------------------
T
-------
S
E
L
I
--------------
A
Y
P
L
L
P
G
S
P
G
L
T
V
A
A
------------
D
G
E
V
S
W
HVDM
A
-------
S
--
T
V
Y
A
R
S
L
G
S
V
----
V
A
Q
L
H
A
-
V
D
A
E
-
A
A
A
A
T
---
G
---
I
-
E
-
V
R
S
----------
P
A
Q
V
---
R
--
G
A
-
W
R
------------
Q
D
L
A
R
-----
V
----
G
A
--
E
F
E
I
A
P
-------
A
L
---
R
E
R
W
E
A
W
L
---
A
D
---
D
GC--
W
-
P
G
----
H
-------
S
---
V
L
T
H
G
E
L
Y
-
P
A
H
T
L
V
E
D
--
E
----
R
I
-
T
A
V
L
D
W
T
T
A
A
V
G
D
P
A
K
D
L
M
F
H
Q
V
S
A
--------------------------------
P
-
S
---
A
I
------------
F
E
V
A
L
Q
A
Y
A
E
--
G
G
G
R
--
P
W
P
--------------------------------------------------------------------------------------------------------
54
HHSearch
45.82
14%
-13
- C4 -
-
4OCV
2
?
A:
[24-309]
-----------------
T
-------
N
E
A
L
F
D
-
V
A
S
H
F
--
A
L--
E
GT-------
V
-
D
-
S
I
E
P
Y
G
D
G
H
I
------
N
-
T
-
T
--
Y
L
V
T
T
D
-
G
P
---------
R
Y
I
L
Q
R
--------
M
N
T
G------
I
FPD
T
V
N
L
----
M
R
N
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
--
K
-
E
-
T
L
D
I
------
V
R
T
T
--------
S
GDTWAEID----
G
-------
G
A
W
R
--------------
V
Y
K
F
I
E
H
T
M
S
Y
N
L
V
P
------------------------------
N
--
P
D
V
F
R
E
A
G
R
A
----
F
G
D
F
Q
N
-
F
L
S
G
-
F
-
D
A
N
---
Q
---
L
T
E
-
T
I
A
H---------
F
H
D
T
P
H
R
F
--
E
D
-
F
K
------------
K
A
L
A
A
-----
D
---
E
L
G
RA
A
-
G
C
G
P
-------
E
I
E
F
Y
L
S
H
A
D
Q
Y
A
V
V
M
D
G
---
L
R
D
--
G
-
S
I
----
P
-------
L
---
R
V
T
H
N
D
T
K
-
L
N
N
I
L
M
D
A
TT
G
----
K
A
-
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
TALEDERDLDK
V
H
F
----------------
S
-
T
---
E
L
------------
F
R
A
Y
T
E
G
F
V
G
E
L
R
D
S
I
--
T
A
R
-
E
A
-----------------------------------------------------------------------------------------------------
55
HHSearch
45.50
14%
-7
- C4 -
-
4WH3
8
NAHK_BIFL2
A:
[4-289]
-----------------
S
-------
N
E
V
L
F
G
-
I
A
S
H
F
--
A
LEG
A
---------
V
-
T
-
G
I
E
P
Y
G
D
G
H
I
------
N
-
T
-
T
--
Y
L
V
T
T
D
G
-
P
---------
R
Y
I
L
Q
Q
--------
M
N
T
S------
I
FPD
T
V
N
L
M
---
R
N
-
V
E
L
V
T
-
S
T
L
K
A
-
Q
-
G
--
K
-
E
-
T
L
D
I
------
V
P
T
T
SGAT
W
A
E
I
D
------------
G
-------
G
A
W
R
--------------
V
Y
K
F
I
E
H
T
V
S
Y
N
L
V
P
------------------------------
N
--
P
D
V
F
R
E
A
G
S
A
----
F
G
D
F
Q
N
-
F
L
S
E
-
F
-
D
A
S
---
Q
L--
T
-
E
-
T
I
A
H---------
F
H
D
T
P
H
R
F
--
E
D
-
F
K
------------
A
A
L
A
A
-----
D
K
L
G
R
A
A
--
A
--
C
Q
P
-------
E
I
D
F
Y
L
S
H
A
D
Q
Y
A
---
V
V
M
D
G
L
R
D
--
G
-
S
I
----
P
--------
L
--
R
V
T
H
N
D
T
K
-
L
N
N
I
L
M
D
A
TT
G
----
K
A
-
R
A
I
I
D
L
D
T
I
M
P
G
S
M
L
F
D
F
G
D
S
I
R
F
G
A
S
TALEDEKDLSK
V
H
F
----------------
S
-
T
---
E
L
------------
F
R
A
Y
T
E
G
F
V
G
E
L
R
G
S
I
--
T
A
R
-
E
A
-----------------------------------------------------------------------------------------------------
59
HHSearch
45.21
13%
30
- C4 -
-
5UXA
-
?
A:
[3-261]
----------------
K
D
-------
I
K
Q
V
I
E
-
I
A
K
K
H
--
N
LFL
K
---------
E
-
E
-
T
I
Q
F
N
E
S
G
L
D
------
F
-
Q
-
A
--
V
F
A
Q
D
N
N
G
I
---------
D
W
V
L
R
L
--------
P
R
R
ED
V
M
P
--
R
------
T
----
K
V
-
E
K
Q
A
L
-
D
L
V
N
K
-
Y
-
A
IS
F
-
Q
-
A
P
N
W
------
I
I
Y
----------------------
T
-------
E
E
L
I
--------------
A
Y
K
K
L
D
G
V
P
A
G
T
I
D
H
NIGNYIWEIDIN
N
---------
V
-------
P
--
E
L
F
H
K
S
L
G
R
V
----
L
A
E
L
H
S
-
I
P
S
N
-
K
-
A
A
A
L
--
D
---
L
-
V
-
V
H
T
----------
P
E
E
A
---
R
--
M
S
-
M
K
------------
Q
R
M
D
A
-----
V
-
R
A
K
F
G
-----
V
G
E
-------
N
L
---
W
N
R
W
Q
A
W
L
---
N
D
D--
D
M---
W
-
P
K
----
K
-------
T
---
G
L
I
H
G
D
V
H
-
A
G
H
T
M
I
D
K
--
D
----
A
N
V
T
G
L
I
D
W
T
E
A
K
V
T
D
V
S
H
D
F
I
F
N
Y
R
A
----------------
F
----------------
G
-
E
---
E
G
------------
L
E
A
L
I
L
A
Y
K
E
--
I
G
G
Y
--
Y
W
P
-
K
------------------------------------------------------------------------------------------------------
48
HHSearch
44.87
14%
4
- C4 -
-
5IGH
-
?
A:
[4-261]
-------------
V
T
T
A
D
-------
T
S
Q
L
Y
A
-
L
A
A
R
H
--
G
L
--
K
L
--------
H
-
G
-
P
L
T
V
N
E
L
G
L
D
------
Y
-
R
-
I
--
V
I
A
T
V
D
D
G
R
---------
R
W
V
L
R
I
--------
P
R
R
A
E
V
S
A
--
K
------
V
----
E
P
-
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
--
F
-
A
-
V
P
D
W
------
R
V
A
N
--------
A
------------
E
L
V
A
Y
P
ML
E
D
S
T
--------------
A
M
V
I
Q
P
G
S
S
T
P
D
W
V
V
------------
P
Q--------
D
-------
S
--
E
V
F
A
E
S
F
A
T
A
----
L
A
A
L
H
A
-
V
P
I
S
-
A
-
A
V
D
---
A
G--
M
-
L
-
I
R
T
----------
P
T
Q
A
R
Q
K
V
--
A
D
-
D
V
------------
D
R
V
R
R
-----
E
----
F
V
-----
V
N
D
-------
K
R
---
L
H
R
W
Q
R
W
L
---
D
D
D--
S
----
S
-
W
P
----
D
-------
F
S
--
V
V
V
H
G
D
L
Y
-
V
G
H
V
L
I
D
N
T-
E
----
R
V
-
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
--------------------------------
G
-
E
---
E
G
------------
L
A
K
L
L
L
T
Y
E
A
--
A
G
G
R
--
V
W
P
-
R
------------------------------------------------------------------------------------------------------
46
HHSearch
44.84
13%
16
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[9-280]
--------------
Q
T
L
H
-------
P
D
T
I
M
D
-
A
L
F
E
H
--
G
I--
R
---------
V
D
S
-
G
L
T
P
L
-
N
S
Y
E
-------
N
R
-
V
--
Y
Q
F
Q
D
E
D
R
R
---------
R
F
V
V
K
F
--------
Y
R
P
ERWT
A
D
-
Q
------
I
----
L
E
-
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
--
V
-
P
-
V
A
A
P
------
V
A
F
N
GQT
L
L
N
H
-
Q
------------
G
-------
F
Y
F
A
--------------
V
F
P
S
V
G
G
R
Q
F
E
A
D
--------------------------------
N
--
I
D
Q
M
E
A
V
G
R
Y
----
L
G
R
M
H
Q
-
T
G
R
K
-
Q
-
L
F
I
---
H
---
R
-
P
-
T
I
G
----------
L
N
E
Y
---
L
--
I
E
-
P
R
------------
K
L
F
E
D
-----
A
-
T
-
L
I
P
--
S
-
G
L
K
A
-------
A
F
---
L
K
A
T
D
E
L
I
---
A
A
---
V
T
A
H
W
R
-
E
D
----
F
-------
T
V
--
L
R
L
H
G
D
C
H
-
A
G
N
I
L
W
R
D
--------
G
-
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
-------------
A
E
----------------
Q
-
R
---
M
Q
------------
L
E
T
I
I
E
A
Y
E
E
--
F
S
E
F
--
D
T
A
-
E
I
-
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
-----------------------------------------------------------------------------------
44
HHSearch
44.31
12%
28
- C4 -
-
6EF6
2
?
A:
[27-322]
-----------------
D
-------
V
T
I
A
Q
Q
-
A
L
T
H
Y
--
D
V--
S
D--------
N
-
A
-
S
L
R
L
L
-
N
L
S
E
-------
N
A
-
T
--
Y
L
V
E
D
G
E
-
H
---------
Q
S
I
L
R
V
--------
H
R
Q
DYHQ
P
H
-
E
------
I
----
E
S
-
E
L
D
W
L
-
A
A
L
R
T
D
S
-
D
--
V
-
T
-
V
P
T
V
------
V
P
A
R
--------
D
GRR
V
V
T
V
D
P
A
DV
P
-------
R
H
V
V
--------------
H
F
E
M
V
G
G
A
E
P
D
E
E
S
L
------------------------------
T
--
L
D
D
F
Q
T
L
G
R
I
----
T
A
S
L
H
E
-
H
S
Q
R
-
W
-
T
R
P
AG
F
G
---
R
-
F
-
S
W
D
----------
W
E
H
C
L
G
D
T
--
P
R
-
W
G
------------
R
W
Q
D
A
-----
E
---
G
V
G
--
A
-
S
E
T
A
-------
L
L
T
R
A
Q
D
L
L
H
R
K
L
---
E
E
---
Y
GS--
G
-
P
D
----
R
--------
Y
--
G
L
I
H
A
D
L
R
-
L
A
N
L
L
V
D
S
--
S
TPQ-
R
T
-
I
T
V
I
D
F
D
D
C
G
F
G
W
Y
F
Y
D
F
G
T
A
V
S
F
I
E
H
D-----------
P
R
----------------
L
-
G
---
E
W
------------
Q
E
S
W
V
A
G
Y
R
S
--
R
R
E
L
--
P
A
A
-
D
E
-
A
M
L
P
S
F
V
F
L
R
R
L
L
L
L
A
W
M
G
S
H
T
------------------------------------------------------------------------------
28
Fugue
43.98
10%
19
- C4 -
-
1ZYL
-
SRKA_ECOLI
A:
[4-328]
---------SAF
T
F
Q
T
L
H
-------
P
D
T
I
M
D
-
A
L
F
E
H
--
G
---
I
---------
R
-
V
-
D
S
G
L
T
P
L
N
S
Y
------
E
N
R
-
V
--
Y
Q
F
Q
D
E
D
R
R
---------
R
F
V
V
K
F
Y
RPERW--
T
A
D
-------
Q
------
I
----
L
E
-
E
H
Q
F
A
-
L
Q
L
V
N
-
D
-
E
--
V
-
P
-
V
A
A
P
------
V
A
F
N
GQT
L
----
L
------------
N
-------
H
Q
G
F
--------------
Y
F
A
V
F
P
S
V
G
G
R
Q
F
E
A
------------
D
---------
N
----------
I
D
Q
M
E
A
V
G
R
Y
----
L
G
R
M
H
Q
-
T
G
-
R
-
K
-
Q
L
F
---
I
---
H
-
R
-
P
T
I
----------
G
-----
L
N
--
E
Y
-
L
I
------------
E
P
R
K
L
-----
F
-
E
D
A
T
L
--
I
-
P
S
G
L
-------
K
A
A
F
-
L
K
A
T
D
E
L
I
---
A
A
---
V
----
T
-
A
H
WRED
F
-------
T
V
--
L
R
L
H
G
D
C
H
-
A
G
N
I
L
W
----
R
----
D
G
-
P
M
F
V
D
L
D
D
A
R
N
G
P
A
V
Q
D
L
W
M
L
L
N
G
D
K
A
------------
E
Q
----------------
R
-
M
---
Q
L
------------
E
T
I
I
E
A
Y
E
E
F
--
S
E
F
D
--------
T
A
E
I
G
L
I
E
P
L
R
A
M
R
L
V
Y
Y
L
A
W
L
M
R
R
W
A
D
P
A
F
P
K
N
F
P
W
L
T
G
E
D
---------
Y
W
L
R
Q
T
A
T
F
I
E
Q
A
K
V
L
Q
E
P
P
L
Q
L
T
P
M
Y
-----------------------
49
HHSearch
43.73
14%
11
- C4 -
-
5IGI
3
?
A:
[4-261]
-------------
V
T
T
A
D
-------
T
S
Q
L
Y
A
-
L
A
A
R
H
--
G
L
--
K
L
--------
H
-
G
-
P
L
T
V
N
E
L
G
L
D
------
Y
-
R
-
I
--
V
I
A
T
V
D
D
G
R
---------
R
W
V
L
R
I
--------
P
R
R
A
E
V
S
A
--
K
------
V
----
E
P
-
E
A
R
V
L
-
A
M
L
K
N
-
R
L
P
--
F
-
A
-
V
P
D
W
------
R
V
A
N
--------
A
------------
E
L
V
A
Y
PML
E
D
S
T
--------------
A
-
V
I
Q
P
G
S
S
T
P
D
W
V
V
------------
P
Q--------
D
-------
S
--
E
V
F
A
E
S
F
A
T
A
----
L
A
A
L
H
A
-
V
P
I
S
-
A
-
A
V
D
---
A
G--
M
-
L
-
I
R
T
----------
P
T
Q
A
R
Q
K
V
--
A
D
-
D
V
------------
D
R
V
R
R
-----
E
----
F
V
-----
V
N
D
-------
K
R
---
L
H
R
W
Q
R
W
L
---
D
D
D--
S
----
S
-
W
P
----
D
-------
F
S
--
V
V
V
H
G
D
L
Y
-
V
G
H
V
L
I
D
N
T-
E
----
R
V
-
S
G
M
I
D
W
S
E
A
R
V
D
D
P
A
I
D
M
A
A
H
L
M
V
F
--------------------------------
G
-
E
---
E
G
------------
L
A
K
L
L
L
T
Y
E
A
--
A
G
G
R
--
V
W
P
-
R
------------------------------------------------------------------------------------------------------