@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKB8: (2017-10-25 )
MLYSLARPMLFSLAPERAHELTLSMLDKAHKLGIMRQTVEAKPTTCMGIEFPNPVGLAAGLDKNGAHIDALAGLGFGFIEIGTITPHPQSGNPKPRLFRIPEAKAIINRMGFNNDGVDKLIENVKASKFRGILGINIGKNADTPVEKAVDDYLICLEKVYNYASYITVNISSPNTKNLRSLQSGDALTELLQALKARQLELAEQYNHYVPLVLKVAPDLTAEDVEFISAQLLDFKIDGLIVTNTTLSREGVENLPYGNESGGLSGAPVFEKSTECLRLFAQTLKGQISLIGVGGILSGEQAAAKQQAGATLVQIYSGLIYTGPTLVKQCVEAMT
Atome Classification :
(82 SA)
--------.....-...-.10........20-----........30.---.---.-.-....40.---.......50........60-........70....-....80.......-.90........100..-.....110.......120-------......--------.---------.130-------..--------.......140.......150.......160.......170.......180.......190.......200..-------..------------...----------210.-......220.......230.......240.......-----250-----....-...260.......270.......280.......290.......300.......310.......320...---....330..---------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--------ML
Y
S
L
-
A
R
P
-
M
L
F
SLA
P
E
R
A
H
E
L
-----
T
L
S
M
L
D
K
A
H
K
L
---
G
---
I
-
M
-
R
Q
T
VEAK---P
T
T
C
M
GIEFPNPVGLAAGL-DKNGA
H
I
D
A
L
A
GL
G
-
F
G
F
I
E
I
GTITPHP-QSGNPK
P
R
L
F
RIP
E
A
K
-
A
I
I
N
RMGFNN
D
G
V
D
K
L
I
--------
E
N
V
K
A
S
--------K---------F
R
---------
G
I
--------
L
G
I
NIGKNADT
P
V
E
K
A
V
D
D
Y
L
I
C
L
E
K
V
YNY
A
S
Y
I
T
V
N
ISSPN
T
K
N
L
R
S
LQS
G
D
A
L
T
E
L
L
Q
A
L
K
A
R
Q
L
E
L
A
E
Q
-------YN------------HY
V
----------
P
L
V
L
-
K
VAPDL
T
A
E
D
V
E
F
I
S
A
Q
L
L
D
F
K
ID
G
L
I
V
TNTTLSRE-----GVE-----NLPY-GNESGGLSGAPVFEK
S
T
E
C
L
R
L
F
A
Q
T
LKG
Q
I
S
L
I
G
VGGILS
G
E
Q
A
A
A
K
Q
QA
G
A
T
L
V
Q
I
Y
S
G
L
IYT
G
P
T
L
---
V
K
Q
C
V
E
AMT---------------------
87
HHSearch
84.42
55%
10
- C5 -
-
1F76
4
PYRD_ECOLI
D:
[1-336]
--------
M
Y
Y
P
F
-
V
R
K
-
A
L
F
Q
L
D
P
E
R
A
H
E
F
-----
T
F
Q
Q
L
R
R
I
T
G
T
---
P
FEA
L
-
V
-
R
Q
K
V
P
A
K
---
P
V
N
C
M
G
L
T
F
K
N
P
L
G
L
A
A
G
L
-
D
K
D
G
E
C
I
D
A
L
G
A
M
G
-
F
G
S
I
E
I
G
T
V
T
P
R
P
-
Q
P
G
N
D
K
P
R
L
F
R
L
V
D
A
E
-
G
L
I
N
R
M
G
F
N
N
L
G
V
D
N
L
V
--------
E
N
V
K
K
A
--------
H
---------
Y
D
---------
G
V
--------
L
G
I
N
I
G
K
N
K
D
T
P
V
E
Q
G
K
D
D
Y
L
I
C
M
E
K
I
Y
A
Y
A
G
Y
I
A
I
N
I
S
S
P
N
T
P
G
L
R
T
L
Q
Y
G
E
A
L
D
D
L
L
T
A
I
K
N
K
Q
N
D
L
Q
A
M
-------
H
H
------------
K
Y
V
----------
P
I
A
V
-
K
I
A
P
D
L
S
E
E
E
L
I
Q
V
A
D
S
L
V
R
H
N
I
D
G
V
I
A
T
N
T
T
L
D
R
S
-----
L
V
Q
-----
G
M
K
N
-
C
D
Q
T
G
G
L
S
G
R
P
L
Q
L
K
S
T
E
I
I
R
R
L
S
L
E
L
N
G
R
L
P
I
I
G
V
G
G
I
D
S
V
I
A
A
R
E
K
I
A
A
G
A
S
L
V
Q
I
Y
S
G
F
I
F
K
G
P
P
L
---
I
K
E
I
V
T
H
I
----------------------
1
PsiBlast_PDB
84.17
54%
14
- C5 -
-
1F76
3
PYRD_ECOLI
A:
[3-333]
----------
Y
P
F
-
V
R
K
-
A
L
F
Q
L
D
P
E
R
A
H
E
F
-----
T
F
Q
Q
L
R
R
I
T
G
T
PFE
A
---
L
-
V
-
R
Q
K
V
P
A
K
---
P
V
N
C
M
G
L
T
F
K
N
P
L
G
L
A
A
G
L
-
D
K
D
G
E
C
I
D
A
L
G
A
M
G
-
F
G
S
I
E
I
G
T
V
T
P
R
P
-
Q
P
G
N
D
K
P
R
L
F
R
L
V
D
A
E
-
G
L
I
N
R
M
G
F
N
N
L
G
V
D
N
L
V
--------
E
N
V
K
K
A
--------
H
---------
Y
D
---------
G
V
--------
L
G
I
N
I
G
K
N
K
D
T
P
V
E
Q
G
K
D
D
Y
L
I
C
M
E
K
I
Y
A
Y
A
G
Y
I
A
I
N
I
S
S
P
N
T
P
G
L
R
T
L
Q
Y
G
E
A
L
D
D
L
L
T
A
I
K
N
K
Q
N
D
L
Q
A
M
-------
H
H
------------
K
Y
V
----------
P
I
A
V
-
K
I
A
P
D
L
S
E
E
E
L
I
Q
V
A
D
S
L
V
R
H
N
I
D
G
V
I
A
T
N
T
T
L
D
R
S
-----
L
V
Q
-----
G
M
K
N
-
C
D
Q
T
G
G
L
S
G
R
P
L
Q
L
K
S
T
E
I
I
R
R
L
S
L
E
L
N
G
R
L
P
I
I
G
V
G
G
I
D
S
V
I
A
A
R
E
K
I
A
A
G
A
S
L
V
Q
I
Y
S
G
F
I
F
K
G
P
P
L
---
I
K
E
I
V
-------------------------
90
HHSearch
79.59
39%
-75
- C5 -
-
4XQ6
1
PYRD_MYCTU
A:
[32-324]
------------------------------------------------------
L
-
L
-
G
P
T
D
P
V
L
---
A
S
T
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
A
H
P
-
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--------
I
R
L
A
R
H
--------
R
---------
P
E
---------
I
P
--------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
L
Q
A
V
E
S
L
R
P
I
L
S
A
V
R
A
E
----------------------------
T
S
T
----------
P
V
L
V
-
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
D
-----
G
L
T
-----
T
P
G
V
D
R
L
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
---
A
K
D
I
H
E
G
I
A
---------------------
91
HHSearch
79.58
39%
-75
* C5 *
-
4XQ6
1
PYRD_MYCTU
B:
[32-324]
------------------------------------------------------
L
-
L
-
G
P
T
D
P
V
L
---
A
S
T
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
A
H
P
-
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--------
I
R
L
A
R
H
--------
R
---------
P
E
---------
I
P
--------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
L
Q
A
V
E
S
L
R
P
I
L
S
A
V
R
A
E
----------------------------
T
S
T
----------
P
V
L
V
-
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
D
-----
G
L
T
-----
T
P
G
V
D
R
L
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
---
A
K
D
I
H
E
G
I
A
---------------------
55
PsiBlast_CBE
77.49
39%
-67
- C5 -
-
4XQ6
1
PYRD_MYCTU
B:
[42-323]
---------------------------------------------------------------------
S
T
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
A
H
P
-
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--------
I
R
L
A
R
H
--------
R
---------
P
E
---------
I
P
--------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
L
Q
A
V
E
S
L
R
P
I
L
S
A
V
R
A
E
T
----------------------------
S
T
----------
P
V
L
V
-
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
D
GLTTP
G
V
D
-----
R
L
-----
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
---
A
K
D
I
H
E
G
I
----------------------
56
PsiBlast_CBE
77.28
39%
-68
- C5 -
-
4XQ6
1
PYRD_MYCTU
A:
[42-323]
---------------------------------------------------------------------
S
T
V
F
G
V
R
F
P
A
P
L
G
L
A
A
G
F
-
D
K
D
G
T
A
L
S
S
W
G
A
M
G
-
F
G
Y
A
E
I
G
T
V
T
A
H
P
-
Q
P
------
L
F
R
L
A
D
D
R
-
A
L
L
N
R
M
G
F
N
N
H
G
A
R
A
L
A
--------
I
R
L
A
R
H
--------
R
---------
P
E
---------
I
P
--------
I
G
V
N
I
G
K
T
K
K
T
P
A
G
D
A
V
N
D
Y
R
A
S
A
R
M
V
G
P
L
A
S
Y
L
V
V
N
V
S
S
P
N
T
P
G
L
R
D
L
Q
A
V
E
S
L
R
P
I
L
S
A
V
R
A
E
T
----------------------------
S
T
----------
P
V
L
V
-
K
I
A
P
D
L
S
D
S
D
L
D
D
I
A
D
L
A
V
E
L
D
L
A
G
I
V
A
T
N
T
T
V
S
R
D
GLTTP
G
V
D
-----
R
L
-----
G
P
G
G
I
S
G
P
P
L
A
Q
R
A
V
Q
V
L
R
R
L
Y
D
R
V
G
D
R
L
A
L
I
S
V
G
G
I
E
T
A
D
D
A
W
E
R
I
T
A
G
A
S
L
L
Q
G
Y
T
G
F
I
Y
G
G
E
R
W
---
A
K
D
I
H
E
G
I
----------------------
86
HHSearch
68.46
38%
33
- C5 -
-
4CQ8
3
PYRD_PLAF7
B:
[30-379]
---------
Y
D
I
F
-
L
K
F
-
C
L
K
Y
I
D
G
E
I
C
H
D
L
-----
F
L
L
L
G
K
Y
-
N
I
L
---
P
---
Y
D
T
-
S
N
D
S
I
Y
A
---
C
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
KRQEEDKLL
S
K
---------
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
K
N
NFLWFNT
T
K
------------
K
K
P
----------
L
V
F
V
-
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
M
K
S
---
A
V
Q
I
K
R
E
L
N
---------------------
89
HHSearch
67.37
41%
33
- C5 -
-
4OQV
6
PYRD_HUMAN
A:
[10-343]
--------------
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
-----
A
V
R
F
T
S
L
-
G
L
L
---
P
R--
A
-
R
-
F
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
Q
K
Q
A
K
L
T
E
-
D
G
---------
L
P
--------
L
G
V
N
L
G
K
N
K
T
S
--
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
---------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
---
V
G
K
V
K
R
E
L
E
---------------------
88
HHSearch
66.08
41%
39
- C5 -
-
2WV8
4
PYRD_HUMAN
A:
[6-344]
---------
F
Y
A
E
H
L
M
P
T
L
Q
G
L
L
D
P
E
S
A
H
R
L
-----
A
V
R
F
T
S
L
-
G
L
L
---
P
R--
A
-
R
-
F
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
E
---------
D
G
---------
L
P
--------
L
G
V
N
L
G
K
N
K
T
S
--
V
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
---------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
---
V
G
K
V
K
R
E
L
E
---------------------
59
PsiBlast_CBE
65.92
40%
17
- C5 -
-
5DEL
5
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
60
PsiBlast_CBE
65.62
40%
4
- C5 -
-
4RX0
3
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
---------
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
77
Fugue
65.29
38%
19
- C5 -
-
1D3G
4
PYRD_HUMAN
A:
[1-367]
MATGD
E
R
F
Y
A
E
H
L
-
M
P
T
-
L
Q
G
L
L
D
P
E
S
A
H
R
L
-----
A
V
R
F
T
S
L
G
L
---------
L
-
P
-
F
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
-F
D
K
H
G
E
A
V
D
G
L
Y
K
M
-G
F
G
F
V
E
I
G
S
V
T
P
K
-P
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
-Q
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
H
R
L
R
A
R
Q
Q
K
Q
A
K
L
T
--------
E
---------
D
G
---------
L
P
--------
L
G
V
N
L
G
K
N
K
T
S
V
--
D
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
----
G
L
G
K
A
E
L
R
R
L
L
T
K
V
L
Q
E
R
D
G
L
R
R
V
-------
H
R
--------------
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
-
S
R
-----
P
A
-GLQGA---
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
---
V
G
K
V
K
R
E
L
E
A
L
L
K
E
Q
GFGGVTDAIGADHRR
18
PsiBlast_PDB
65.22
41%
34
- C5 -
-
3G0X
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
69
PsiBlast_CBE
64.94
40%
20
- C5 -
-
5BOO
3
PYRD_PLAF7
B:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
QEEDKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMNDEFLWFNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
4
PsiBlast_PDB
64.88
42%
42
- C5 -
-
1UUO
3
PYRD_RAT
A:
[26-353]
----------------------
L
D
P
E
S
A
H
R
L
-----
A
V
----
R
V
T
S
L
---
G
---
L
-
L
P----
Q
D
S
DML
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
--
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
--------
Q
G
K
T
E
L
R
H
L
L
S
--
K
V
L
Q
E
R
D
A
L
K
-------
G
T
------------
R
K
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
V
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
----------------------
70
PsiBlast_CBE
64.76
40%
18
- C5 -
-
5BOO
3
PYRD_PLAF7
A:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMNDEFLWFNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
61
PsiBlast_CBE
64.64
40%
19
- C5 -
-
4ORM
4
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
53
PsiBlast_CBE
64.55
41%
35
- C5 -
-
2FPT
3
PYRD_HUMAN
A:
[49-376]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
46
PsiBlast_CBE
64.49
41%
34
- C5 -
-
3KVJ
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
65
PsiBlast_CBE
64.47
40%
22
- C5 -
-
4CQ9
3
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
D
KLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
FLWFNTT-----
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
21
PsiBlast_CBE
64.40
42%
38
- C5 -
-
1UUM
4
PYRD_RAT
B:
[26-353]
----------------------
L
D
P
E
S
A
H
R
L
-----
A
V
----
R
V
T
S
L
---
G
---
L
-
L
P
R
A
T
F
Q
D
S
DML
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
QLTADGLP
L
G
I
N
L
G
K
N
K
T
S
--
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
--
K
V
L
Q
E
R
D
A
L
K
-------
G
T
------------
R
K
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
V
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
VVR
V
K
R
E
L
E
A
L
----------------------
31
PsiBlast_CBE
64.39
41%
36
- C5 -
-
4RLI
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
5
PsiBlast_PDB
64.37
41%
37
- C5 -
-
3U2O
3
PYRD_HUMAN
A:
[49-376]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
-
K
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
71
PsiBlast_CBE
64.32
40%
22
- C5 -
-
3O8A
3
PYRD_PLAF7
A:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
30
PsiBlast_CBE
64.31
41%
36
- C5 -
-
4RR4
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
58
PsiBlast_CBE
64.29
40%
7
- C5 -
-
5FI8
3
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
-----------
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
57
PsiBlast_CBE
64.27
40%
0
- C5 -
-
5TBO
4
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
------------
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
36
PsiBlast_CBE
64.23
41%
36
- C5 -
-
4LS0
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
66
PsiBlast_CBE
64.21
40%
30
- C5 -
-
4CQ8
3
PYRD_PLAF7
B:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
QEEDKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
FLWFNTT-----
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
44
PsiBlast_CBE
64.17
41%
36
- C5 -
-
3KVL
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
17
PsiBlast_PDB
64.11
41%
37
- C5 -
-
3G0U
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
43
PsiBlast_CBE
64.10
41%
33
- C5 -
-
3KVM
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
12
PsiBlast_PDB
64.06
41%
37
- C5 -
-
2PRL
4
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
2
PsiBlast_PDB
64.06
42%
44
- C5 -
-
4ORI
3
PYRD_RAT
A:
[18-345]
----------------------
L
D
P
E
S
A
H
R
L
-----
A
V
----
R
V
T
S
L
---
G
---
L
-
L
P
R
A
T
F
Q
D
S
DML
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
--
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
------
Q
G
K
T
E
L
R
H
L
L
S
--
K
V
L
Q
E
R
D
A
L
K
-------
G
T
------------
R
K
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
V
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
----------------------
6
PsiBlast_PDB
64.02
41%
36
- C5 -
-
2WV8
4
PYRD_HUMAN
A:
[19-346]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
52
PsiBlast_CBE
64.01
41%
34
- C5 -
-
2FPV
3
PYRD_HUMAN
A:
[49-376]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
41
PsiBlast_CBE
64.01
41%
36
- C5 -
-
4JGD
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
64
PsiBlast_CBE
63.92
40%
24
- C5 -
-
4CQ9
3
PYRD_PLAF7
B:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
QEEDKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
FLWFNTT-----
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
34
PsiBlast_CBE
63.88
41%
34
- C5 -
-
4LS2
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
47
PsiBlast_CBE
63.87
41%
38
- C5 -
-
2B0M
3
PYRD_HUMAN
A:
[47-374]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
40
PsiBlast_CBE
63.84
41%
34
- C5 -
-
4JS3
8
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
9
PsiBlast_PDB
63.83
41%
37
- C5 -
-
1D3H
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
10
PsiBlast_PDB
63.79
41%
34
- C5 -
-
2BXV
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
3
PsiBlast_PDB
63.78
42%
39
- C5 -
-
1UUM
4
PYRD_RAT
A:
[26-353]
----------------------
L
D
P
E
S
A
H
R
L
-----
A
V
----
R
V
T
S
L
---
G
---
L
-
L
P
R
A
T
F
Q
D
S
DML
E
V
K
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
N
G
E
A
V
D
G
L
Y
K
L
G
-
F
G
F
V
E
V
G
S
V
T
P
Q
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
Q
L
T
A
D
G
L
P
L
G
I
N
L
G
K
N
K
T
S
--
E
D
A
A
A
D
Y
A
E
G
V
R
T
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
---------
Q
G
K
T
E
L
R
H
L
L
S
--
K
V
L
Q
E
R
D
A
L
K
-------
G
T
------------
R
K
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
A
Q
D
K
E
D
I
A
S
V
A
R
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
V
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
I
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
Q
A
G
A
S
L
V
Q
L
Y
T
A
L
I
F
L
G
P
P
V
V
V
R
V
K
R
E
L
E
A
L
----------------------
48
PsiBlast_CBE
63.77
41%
34
- C5 -
-
5K9D
4
PYRD_HUMAN
A:
[22-349]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
28
PsiBlast_CBE
63.77
41%
36
- C5 -
-
4ZL1
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
19
PsiBlast_PDB
63.77
41%
39
- C5 -
-
3ZWS
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
--
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
50
PsiBlast_CBE
63.75
41%
38
- C5 -
-
2FQI
3
PYRD_HUMAN
A:
[49-376]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
-
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
39
PsiBlast_CBE
63.67
41%
36
- C5 -
-
4JTS
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
24
PsiBlast_CBE
63.64
41%
37
- C5 -
-
5HQE
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
15
PsiBlast_PDB
63.64
41%
37
- C5 -
-
3FJ6
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
14
PsiBlast_PDB
63.63
41%
38
- C5 -
-
3F1Q
5
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
74
PsiBlast_CBE
63.56
40%
11
- C5 -
-
3I65
4
PYRD_PLAF7
A:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
--------
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
67
PsiBlast_CBE
63.55
40%
27
- C5 -
-
4CQ8
3
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
D
KLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
FLWFNTT-----
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
32
PsiBlast_CBE
63.42
41%
34
- C5 -
-
4RKA
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
38
PsiBlast_CBE
63.41
41%
36
- C5 -
-
4JTT
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
37
PsiBlast_CBE
63.40
41%
36
- C5 -
-
4JTU
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
16
PsiBlast_PDB
63.40
41%
37
- C5 -
-
3FJL
5
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
51
PsiBlast_CBE
63.39
41%
36
- C5 -
-
2FPY
3
PYRD_HUMAN
A:
[49-376]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
13
PsiBlast_PDB
63.38
41%
39
- C5 -
-
2PRM
2
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
45
PsiBlast_CBE
63.37
41%
34
- C5 -
-
3KVK
4
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
20
PsiBlast_PDB
63.32
41%
37
- C5 -
-
3ZWT
3
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
---
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
73
PsiBlast_CBE
63.27
40%
24
- C5 -
-
3I68
3
PYRD_PLAF7
A:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
8
PsiBlast_PDB
63.26
41%
38
- C5 -
-
1D3G
4
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
22
PsiBlast_CBE
63.25
41%
38
- C5 -
-
4IGH
6
PYRD_HUMAN
A:
[18-345]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
----------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
----
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
27
PsiBlast_CBE
63.23
41%
37
- C5 -
-
4ZMG
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
35
PsiBlast_CBE
63.19
41%
35
- C5 -
-
4LS1
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
62
PsiBlast_CBE
63.16
40%
25
- C5 -
-
4CQA
3
PYRD_PLAF7
B:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
D
KLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
FLWFNTT-----
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
42
PsiBlast_CBE
63.11
41%
37
- C5 -
-
3W7R
20
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
25
PsiBlast_CBE
63.02
41%
38
- C5 -
-
5HIN
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
26
PsiBlast_CBE
62.99
41%
35
- C5 -
-
5H2Z
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
33
PsiBlast_CBE
62.68
41%
35
- C5 -
-
4RK8
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
68
PsiBlast_CBE
62.62
40%
15
- C5 -
-
3SFK
3
PYRD_PLAF7
A:
[71-366]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
-------
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
23
PsiBlast_CBE
62.62
41%
31
- C5 -
-
5MVC
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
----------
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
-
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
72
PsiBlast_CBE
62.49
40%
25
- C5 -
-
3I6R
3
PYRD_PLAF7
A:
[86-381]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMN
D
E
F
L
W
FNTT
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-----
S
--
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
63
PsiBlast_CBE
62.41
40%
29
- C5 -
-
4CQA
3
PYRD_PLAF7
A:
[72-367]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
DKLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
-
E
E
I
D
N
L
E
K
-------
N
N
IMNFLWFNTT--
K
K
K
----------
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------
54
PsiBlast_CBE
62.17
41%
34
- C5 -
-
4OQV
6
PYRD_HUMAN
A:
[18-345]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
11
PsiBlast_PDB
61.80
41%
35
- C5 -
-
2PRH
4
PYRD_HUMAN
A:
[21-348]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
---------
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
S
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
29
PsiBlast_CBE
61.78
41%
33
- C5 -
-
4YLW
3
PYRD_HUMAN
A:
[44-371]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
R
A
R
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
N
T
A
G
L
R
S
L
Q
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
-
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
7
PsiBlast_PDB
61.54
41%
30
- C5 -
-
5MUT
3
PYRD_HUMAN
A:
[19-346]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
---
F
-------------
Q
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
Q
A
K
L
T
E
D
--
G
L
P
-------
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
------------
G
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
-
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
49
PsiBlast_CBE
61.42
41%
31
- C5 -
-
5MVD
3
PYRD_HUMAN
A:
[17-344]
----------------------
L
D
P
E
S
A
H
R
L
A
V
R
F
T
S
L
G
L
L
P
------------------
D
S
D
M
L
---
E
V
R
V
L
G
H
K
F
R
N
P
V
G
I
A
A
G
F
-
D
K
H
G
E
A
V
D
G
L
Y
K
M
G
-
F
G
F
V
E
I
G
S
V
T
P
K
P
-
Q
E
G
N
P
R
P
R
V
F
R
L
P
E
D
Q
-
A
V
I
N
R
Y
G
F
N
S
H
G
L
S
V
V
E
--------
H
R
L
R
A
R
--------
Q
---------
Q
K
---------
Q
A
K
L
T
E
D
G
L
P
L
G
V
N
L
G
K
N
K
-
T
S
V
D
-
A
A
E
D
Y
A
E
G
V
R
V
L
G
P
L
A
D
Y
L
V
V
N
V
S
S
P
----------
K
A
E
L
R
R
L
L
T
--
K
V
L
Q
E
R
D
G
L
R
-------
R
V
------------
H
R
P
----------
A
V
L
V
-
K
I
A
P
D
L
T
S
Q
D
K
E
D
I
A
S
V
V
K
E
L
G
I
D
G
L
I
V
T
N
T
T
V
S
R
P
-----
A
G
L
-----
Q
G
A
L
-
R
S
E
T
G
G
L
S
G
K
P
L
R
D
L
-
T
Q
T
I
R
E
M
Y
A
L
T
Q
G
R
V
P
I
I
G
V
G
G
V
S
S
G
Q
D
A
L
E
K
I
R
A
G
A
S
L
V
Q
L
Y
T
A
L
T
F
W
G
P
P
V
V
G
K
V
K
R
E
L
E
A
L
----------------------
75
PsiBlast_CBE
61.29
37%
25
- C5 -
-
1TV5
3
PYRD_PLAF7
A:
[84-409]
---------------------------------------------------------------------
T
N
I
K
H
L
D
F
I
N
P
F
G
V
A
A
G
F
-
D
K
N
G
V
C
I
D
S
I
L
K
L
G
-
F
S
F
I
E
I
G
T
I
T
P
R
G
-
Q
T
G
N
A
K
P
R
I
F
R
D
V
E
S
R
-
S
I
I
N
S
C
G
F
N
N
M
G
C
D
K
V
T
--------
E
N
L
I
L
F
--------
R
---------
K
R
Q
E
E
D
KLLSK
H
I
--------
V
G
V
S
I
G
K
N
K
D
T
V
--
N
I
V
D
D
L
K
Y
C
I
N
K
I
G
R
Y
A
D
Y
I
A
I
N
V
S
S
P
N
T
P
G
L
R
D
N
Q
E
A
G
K
L
K
N
I
I
L
S
V
K
E
E
I
D
N
L
E
--------------------------FLWFNTTKKK
P
L
V
F
V
K
L
A
P
D
L
N
Q
E
Q
K
K
E
I
A
D
V
L
L
E
T
N
I
D
G
M
I
I
S
N
T
T
T
Q
I
N
-----
D
I
K
-------
S
F
-
E
N
K
K
G
G
V
S
G
A
K
L
K
D
I
S
T
K
F
I
C
E
M
Y
N
Y
T
N
K
Q
I
P
I
I
A
S
G
G
I
F
S
G
L
D
A
L
E
K
I
E
A
G
A
S
V
C
Q
L
Y
S
C
L
V
F
N
G
------------------------------------