@TOME V2.3
(Mar 2018)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKX6: (2017-10-30 )
MTSYANLLKPLHLGFTTIKNRVVMGSMHTGLEDRFFNYPKLAAYFEERAKGGVGLIVTGGISPNRQGWLAPAGGTMNSLFDIPQHRLVTHAVHKHGSKILMQILHAGRYGYQPFVVSSSPIKSPISPFKPRQLSEKNILSTIEDYAQCADIAKKAGYDGVEIMGSEGYLINQFLSRHVNQRTDRWGGEIENRMRFPVEIVKAIRAKVGEKFIICFRLSLLDLVHDGNTMQEVVTVAKALEKAGVTLLNTGIGWHEARVPTIVTSVPRAAFVDYTAHVKQHISIPVIASNRINMPETAEEILATGKADMIQMARPLLADAFWVNKTATNRVDEINTCIACNQACLDHAFKNKRVSCLVNPRAGHETELVYLKTKQPKRIAVVGGGVAGMSAATVAASRGHAVTLFEANADVGGQFNFAKVVPGKEEFHETIRYFKVQLQKTGVDVRLNTRVNREQLEREGFDEVIVATGVVPRALKIEGSNSPQVLSYAQVLQGAEVGRKVAVIGAGGIGFDVSEFLLKPPHQPQSQPLAEWQREWGVDPDPNYVSEGGMQPPVVEPAIREIYLLQRKTTPLGVGLGKTSGWVHRAQLKKHGVRMLRGVQYKAVTDEGLWIEHNGQDQLLRVDTVVVCAGQESVKDLMPKEGESTIANYHIIGGAKLAAELDAKRAIKEGAELAAQL
Atome Classification :
(20 SA)
-.........10........20.--...--....30..--......40-.......-..50........60-.........-70.-....-....80------.........90........100.......-------110----..------.-----------.----.....120.-..---------------.------------....130.......140----.......150.......160......-.-170.......180.......190.......200.......210.......220-..---.....230-.........240------.--......250.----.......260-...--.....270--........280.......290.......300.......310.......320.......330.......340......-.350.......360.....-----..----370---.-.....-...380.......390.......400.......410.......420...--....430...-....-440---......---.-..450.......460.......470--------.--------......480------------.--------.......490.-..-....500....--.--..510.......520.......530.......540-.........550.--......560.......570...-...-.-580.......590.......600.......610-----------------.--.--.......620.......630----.......640------........650.......660.......670....--------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-MT
S
Y
A
N
L
L
K
P
L
H
L
G
F
T
T
IKN
R
V
--
V
MG--SMHTGL
E
D
--
R
FFN
Y
P
K
--
L
A
A
Y
F
E
E
-RAKGG
V
G
L
I
V
TGG--ISPNRQGWL-A-P-AGGT-
M
N
S
L
F-------DI
P
Q
H
R
L
V
T
H
A
V
H
K
H
G
S
K
I
L
M
Q
I
L
HAGRY-------G------YQ------
P
-----------
F
----
V
VSSSPI-K-SP---------------I------------SPFKPRQL
S
E
K
N
I
L
S
T
I
----
E
D
Y
A
Q
C
A
D
I
A
K
KAGYD
G
V
E
I
MGSE
G
Y
-
L
-
I
N
Q
F
L
S
R
H
V
N
Q
R
T
D
RWG
G
E
I
E
N
RMRF
P
V
E
I
V
K
A
I
R
A
KVG
E
K
F
I
I
C
F
R
L
S
L
L
D
L
-VH---DG
N
T
M
Q
---
E
V
V
T
V
A
K
A
L
E
K
A------G--
V
T
L
L
NTG-IG----WHEARV
P
T
-
I
-
V
TS--VPR
A
A
F
V
---
D
Y
T
A
H
V
K
Q
HIS
I
P
V
I
ASNRINM
P
E
T
A
E
E
I
L
ATG
K
A
D
M
I
Q
M
A
R
P
L
L
A
D
A
F
WVNKTATN
R
V
D
E
I
N
T
C
I
A
C
N
Q
A
C
L
D
H
A
F-KNK
R
V
S
C
L
VNPRAGHE
T
E
L
-----
V
Y
----
L
-----K-TKQP
K
-
R
I
A
V
VGGGVAGM
S
A
A
T
V
AASRG
H
A
V
T
L
F
EANADVGGQF
N
F
A
KVVP
G
K
E
E
--
F
H
E
T
I
R
Y
F
K
V
-
Q
L
QK-T-----G
V
D
V
R
L
---N-TRV
N
R
E
Q
L
E
REGFD
E
V
I
V
ATGVV
P
R
--------
A
--------
L
K
IEGSNS-------------
P
--------
Q
V
L
S
Y
A
Q
V
L
Q
G
-
A
E-VG
R
K
V
A
V
I
GAG--G--IGF
D
V
S
E
F
L
LKPPHQPQSQ
P
L
A
E
W
Q
R
EWGVDPD---P
N
Y
V
SEGGMQPPV--V
E
P
A
I
R
E
I
Y
L
LQRKTTPLGVGL-GKT-S-G
W
V
H
R
A
Q
L
K
K
H
G
V
R
M
L
RGV
Q
Y
K
A
VTDE
G
L
W
I
-------------------E--H--NGQD
Q
L
L
R
V
D
T
V
V
V
CAG
Q
E
S
----
V
K
D
LMPKEG-------ESTIA
N
Y
H
I
IGG
A
K
L
A
A
E
L
D
A
K
R
A
I
K
E
G
A
E
L
A
AQL--------------------
77
HHSearch
85.89
53%
-61
- C7 -
-
1PS9
5
FADH_ECOLI
A:
[1-671]
---
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
--
L
M
G
--
S
M
H
T
G
L
E
E
--
Y
P
D
G
A
E
R
--
L
A
A
F
Y
A
E
-
R
A
R
H
G
V
A
L
I
V
S
G
G
--
I
A
P
D
L
T
G
V
G
-
M
-
E
-
G
G
A
M
-
L
N
D
A
S
-------
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
-------
S
------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
-
A
P
---------------
I
------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
----
D
N
F
A
R
C
A
Q
L
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
-
V
E
---
D
G
G
T
F
A
---
E
T
V
E
L
A
Q
A
I
E
A
A
------
G
--
A
T
I
I
N
T
G
-
I
G
----
W
H
E
A
R
I
P
T
-
I
-
A
T
P
--
V
P
R
G
A
F
S
---
W
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
F
-
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
-----
P
I
----
L
-----
P
-
A
V
Q
K
K
-
N
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
--
F
Y
E
T
L
R
Y
Y
R
R
-
M
I
E
V
-
T
-----
G
V
T
L
K
L
---
N
-
H
T
V
T
A
D
--
Q
L
Q
A
F
D
E
T
I
L
A
S
G
I
V
P
R
--------
T
--------
P
P
I
D
G
I
D
H
-------------
P
--------
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
-
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
Q
P
G
E
S
T
-
S
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
---
L
Q
Q
--
A
G
G
L
S
P
Q
G
M
Q
I
P
R
S
P
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
-
G
K
T
-
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
-------------------
V
--
I
--
N
G
E
T
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
----
N
R
A
L
A
Q
P
L
--------
I
D
S
G
K
T
V
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
1
PsiBlast_PDB
85.70
52%
-60
- C7 -
-
1PS9
5
FADH_ECOLI
A:
[1-671]
---
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
--
L
M
G
--
S
M
H
T
G
L
E
E
--
Y
P
D
G
A
E
R
--
L
A
A
F
Y
A
E
-
R
A
R
H
G
V
A
L
I
V
S
G
G
--
I
A
P
D
L
T
G
V
G
-
M
-
E
-
G
G
A
M
-
L
N
D
A
S
-------
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
-------
S
------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
-
A
P
---------------
I
------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
----
D
N
F
A
R
C
A
Q
L
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
-
V
E
---
D
G
G
T
F
A
---
E
T
V
E
L
A
Q
A
I
E
A
A
------
G
--
A
T
I
I
N
T
G
-
I
G
----
W
H
E
A
R
I
P
T
-
I
-
A
T
P
--
V
P
R
G
A
F
S
---
W
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
F
-
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
-----
P
I
----
L
-----
P
-
A
V
Q
K
K
-
N
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
--
F
Y
E
T
L
R
Y
Y
R
R
-
M
I
E
V
-
T
-----
G
V
T
L
K
L
---
N
-
H
T
V
T
A
D
Q
L
--
Q
A
F
D
E
T
I
L
A
S
G
I
V
P
R
--------
T
--------
P
P
I
D
G
I
D
H
-------------
P
--------
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
-
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
Q
-
P
G
E
S
T
S
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
LQQ
A
G
G
L
S
P
Q
G
M
Q
I
P
-----
R
S
P
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
-
G
K
T
-
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
-------------------
V
--
I
--
N
G
E
T
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
----
N
R
A
L
A
Q
P
L
I
-------
D
S
G
-
K
T
V
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
67
Fugue
85.20
52%
-66
- C7 -
-
1PS9
5
FADH_ECOLI
A:
[1-671]
---
S
Y
P
S
L
F
A
P
L
D
L
G
F
T
T
L
K
N
R
V
--
L
M
G
--
S
M
H
T
G
L
E
E
--
Y
P
D
G
A
E
R
--
L
A
A
F
Y
A
E
-
R
A
R
H
G
V
A
L
I
V
S
G
G
--
I
A
P
D
L
T
G
V
G
-
M
-
E
-
G
G
A
M
-
L
N
D
A
S
-------
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
-------
S
------
Y
Q
------
P
-----------
H
----
L
V
A
P
S
A
L
-
Q
-
A
P
---------------
I
------------
N
R
F
V
P
H
E
L
S
H
E
E
I
L
Q
L
I
----
D
N
F
A
R
C
A
Q
L
A
R
E
A
G
Y
D
G
V
E
V
M
G
S
E
G
Y
-
L
-
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
-
V
E
---
D
G
G
T
F
A
---
E
T
V
E
L
A
Q
A
I
E
A
A
------
G
--
A
T
I
I
N
T
G
-
I
G
----
W
H
E
A
R
I
P
T
-
I
-
A
T
P
--
V
P
R
G
A
F
S
---
W
V
T
R
K
L
K
G
H
V
S
L
P
L
V
T
T
N
R
I
N
D
P
Q
V
A
D
D
I
L
S
R
G
D
A
D
M
V
S
M
A
R
P
F
L
A
D
A
E
L
L
S
K
A
Q
S
G
R
A
D
E
I
N
T
C
I
G
C
N
Q
A
C
L
D
Q
I
F
-
V
G
K
V
T
S
C
L
V
N
P
R
A
C
H
E
T
K
M
-----
P
I
----
L
-----
P
-
A
V
Q
K
K
-
N
L
A
V
V
G
A
G
P
A
G
L
A
F
A
I
N
A
A
A
R
G
H
Q
V
T
L
F
D
A
H
S
E
I
G
G
Q
F
N
I
A
K
Q
I
P
G
K
E
E
--
F
Y
E
T
L
R
Y
Y
R
R
-
M
I
E
V
-
T
-----
G
V
T
L
K
L
---
N
-
H
T
V
T
A
D
Q
L
Q
A
--
F
D
E
T
I
L
A
S
G
I
V
P
R
--------
T
--------
P
P
I
D
G
I
D
H
-------------
P
--------
K
V
L
S
Y
L
D
V
L
R
D
K
A
P
-
V
G
N
K
V
A
I
I
G
C
G
--
G
--
I
G
F
D
T
A
M
Y
L
S
Q
P
G
E
S
-
T
S
Q
N
I
A
G
F
C
N
E
W
G
I
D
S
S
---
L
Q
Q
A
G
G
L
S
P
Q
G
M
Q
--
I
P
R
S
P
R
Q
I
V
M
L
Q
R
K
A
S
K
P
G
Q
G
L
-
G
K
T
-
T
-
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
G
V
S
Y
Q
K
I
D
D
D
G
L
H
V
-------------------
V
--
I
--
N
G
E
T
Q
V
L
A
V
D
N
V
V
I
C
A
G
Q
E
P
----
N
R
A
L
-
A
Q
P
L
-------
I
D
S
G
K
T
V
H
L
I
G
G
C
D
V
A
M
E
L
D
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
--------------------
68
Fugue
56.92
25%
17
- C7 -
-
3K30
3
?
A:
[7-690]
V
A
A
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
--
Y
Q
V
--
P
H
C
N
G
M
G
Y
--
R
--
D
P
S
A
--
Q
A
S
M
R
K
I
-
K
A
E
G
G
W
S
A
V
C
T
E
Q
--
V
E
I
H
A
T
S
D
I
-
A
-
P
-
F
I
E
L
R
I
W
D
D
Q
-------
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
-------
A
------
P
N
QLSR
E
T
P
-----------
L
----
G
P
G
H
L
P
V
A
P
-
D
T
---------------
I
------------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
----
R
W
H
R
N
A
V
R
R
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
S
G
-
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
G
R
A
A
V
A
C
R
I
T
V
E
E
E
-
I
D
---
G
G
I
T
R
E
---
D
I
E
G
V
L
R
E
L
G
E
-------
L
--
P
D
L
W
D
F
A
-
M
G
----
S
W
E
G
D
S
V
T
---
S
R
F
--
A
P
E
G
R
Q
E
---
E
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
-
I
C
V
S
G
D
L
-
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
-----
G
W
----
H
PERIR
A
-
K
E
S
D
A
-
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
--
W
G
R
V
K
E
Y
R
E
A
-
V
L
A
E
L
P
-----
N
V
E
I
Y
R
---
E
-
S
P
M
T
G
D
D
I
V
E
F
G
F
E
H
V
I
T
A
T
G
A
T
W
R
TDGVARFH
T
--------
T
A
L
P
I
A
E
G
-------------
M
--------
Q
V
L
G
P
D
D
L
F
A
G
-
R
L
P
D
G
K
K
V
V
V
Y
D
D
D
--
H
YY
L
G
G
V
V
A
E
L
L
A
Q
K
G
Y
-------------------------------------------
E
V
S
I
V
T
P
G
A
-
Q
V
S
S
W
T
-
N
N
T
-
F
E
V
N
R
I
Q
R
R
L
I
E
N
G
V
A
R
V
T
D
H
A
V
V
A
V
G
A
G
G
V
T
V
-------------------
R
D
T
Y
--
A
S
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
RE
E
L
Y
L
D
L
V
A
R
R
D
-------
A
G
E
I
A
S
V
R
G
I
G
D
A
--
W
A
P
G
T
I
A
A
A
V
W
S
G
R
R
A
A
E
E
F
DAVLPSNDEVP
F
R
R
E
V
T
QLA
78
HHSearch
55.74
24%
12
- C7 -
-
1O94
3
DHTM_METME
B:
[3-695]
-
D
P
K
H
D
I
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
--
Y
Q
V
--
P
H
C
I
G
A
G
S
--
D
K
--
P
G
F
--
Q
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
P
E
S
D
D
T
H
-
R
-
L
S
A
R
-
I
W
D
E
G
-------
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
A
H
-------
A
------
P
N
------
M
ESRA-------
T
----
P
R
G
P
S
Q
Y
-
A
-
S
E
---------------
F
E-----------
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
----
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
V
D
T
V
Y
G
P
---
G
Q
I
E
A
E
V--
D
G
Q
K
F
V
E
M
A
D
S
-------
L
--
V
D
M
W
D
I
T
-
I
G
----
D
I
A
E
W
G
E
D
A
G
P
S
R
F
--
Y
Q
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
-
C
I
S
R
W
E
I
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
-----
G
W
----
H
PEKFR
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
--
W
S
Y
H
R
D
Y
R
E
T
-
Q
I
T
K
-
L
LKKNK
E
S
Q
L
A
L
---
G
Q
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
R
W
N
--------
T
DGTNCLTH
D
P
I
P
G
A
D
A
SL-----------
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
D
TY
F
--
M
A
P
S
L
A
E
K
L
A
T
A
G
H
-------------------------------------------
E
V
T
I
V
S
G
V
-
H
L
A
-
N
Y
M
-
H
F
T
L
E
-
Y
P
N
M
M
R
R
L
H
E
L
H
V
E
E
L
G
D
H
F
C
S
R
I
E
P
G
R
M
E
I
YNIWGDGSKRTYRGPGVSP
R
D-
A
--
N
T
S
H
R
W
I
E
F
D
S
L
V
L
V
T
G
R
H
S
----
E
C
T
L
W
N
E
L
K
ARESEWA
E
N
D
I
K
G
I
Y
L
I
G
D
A
E
--
A
P
R
L
I
A
D
A
T
F
T
G
H
R
V
A
R
E
I
--------------------
79
HHSearch
54.95
24%
16
- C7 -
-
3K30
3
?
B:
[9-670]
--
A
P
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
--
Y
Q
V
--
P
H
C
N
G
M
G
Y
----
R
D
P
S
A
--
Q
A
S
M
R
K
I
-
K
A
E
G
G
W
S
A
V
C
T
E
Q
--
V
E
I
H
A
T
S
D
I
-
A
P
F
-
I
E
L
R
-
I
W
D
D
Q
-------
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
-------
A
------
P
N
------
Q
-----------
L
SRET
P
L
G
P
G
H
L
-
P
-
V
A
---------------
P
DTI---------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
----
R
W
H
R
N
A
V
R
R
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
-
S
G
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
G
R
A
A
V
A
C
R
I
T
V
E
E
E
-
I
D
---
G
G
I
T
R
E
---
D
I
E
G
V
L
R
E
L
G
E
L
---------
P
D
L
W
D
F
A
-
M
G
----
S
W
E
G
D
S
V
--
T
-
S
R
F
--
A
P
E
G
R
Q
E
---
E
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
I
G
A
A
R
P
S
I
A
D
P
F
L
P
N
K
I
R
D
G
R
L
N
L
I
R
E
C
I
G
C
N
I
-
C
V
S
G
D
L
-
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
-----
G
W
----
H
PERI-
R
A
K
E
S
D
A
-
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
--
W
G
R
V
K
E
Y
R
E
A
-
V
L
A
E
-
L
P----
N
V
E
I
Y
R
---
E
-
S
P
M
T
G
D
D
I
V
E
F
G
F
E
H
V
I
T
A
T
G
A
T
W
R
--------
T
--------
D
G
V
A
R
F
H
T
-------------
T
ALPIAEGM
Q
V
L
G
P
D
D
L
F
A
G
R
L
P
-
D
G
K
K
V
V
V
Y
D
D
D
HY
Y
--
L
G
G
V
V
A
E
L
L
A
Q
K
G
Y
-------------------------------------------
E
V
S
I
V
T
P
G
-
A
Q
V
S
S
W
T
N
N
T
F
-
E
-
V
N
R
I
Q
R
R
L
I
E
N
G
V
A
R
V
T
D
H
A
V
V
A
V
G
A
G
G
V
T
V
-------------------
R
--
D
TY
A
S
I
E
R
E
L
E
C
D
A
V
V
M
V
T
A
R
L
P
----
R
E
E
L
Y
L
D
L
V
ARRD---
A
G
E
I
A
S
V
R
G
I
G
D
A
W
--
A
P
G
T
I
A
A
A
V
W
S
G
R
R
A
A
E
E
F
--------------------
7
PsiBlast_PDB
46.27
25%
21
- C8 -
-
3K30
3
?
A:
[11-489]
----
Y
D
V
L
F
E
P
V
Q
I
G
P
F
T
T
K
N
R
F
--
Y
Q
V
--
P
H
C
N
G
M
G
-----
Y
R
D
P
S
--
A
Q
A
S
M
R
K
I
K
A
E
G
G
W
S
A
V
C
T
E
Q
--
V
E
I
H
A
T
S
D
I
-
A
-
P
F
I
E
L
R
-
I
W
D
D
Q
-------
D
L
P
A
L
K
R
I
A
D
A
I
H
E
G
G
G
L
A
G
I
E
L
A
H
N
G
M
N
-------
A
PNQLSR
E
T
------
P
-----------
L
----
G
P
G
H
L
P
V
-
A
P
D
T
---------------
I
------------
A
P
I
Q
A
R
A
M
T
K
Q
D
I
D
D
L
R
----
R
W
H
R
N
A
V
R
R
S
I
E
A
G
Y
D
I
V
Y
V
Y
G
A
H
G
Y
-
S
G
V
H
H
F
L
S
K
R
Y
N
Q
R
T
D
E
Y
G
G
S
L
E
N
R
M
R
L
L
R
E
L
L
E
D
T
L
D
E
C
A
G
R
A
A
V
A
C
R
I
T
V
E
E
E
-
I
D
---
G
G
I
T
R
E
---
D
I
E
G
V
L
R
E
L
G
E
L
---------
P
D
L
W
D
F
A
-
M
G
----
S
W
E
G
---
D
-
S
-
V
T
S
RF
A
P
E
G
R
Q
E
---
E
F
V
A
G
L
K
K
L
T
T
K
P
V
V
G
V
G
R
F
T
S
P
D
A
M
V
R
Q
I
K
A
G
I
L
D
L
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A
A
R
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I
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D
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F
L
P
N
K
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D
G
R
L
N
L
I
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C
I
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C
N
-
I
C
V
S
G
D
L
-
T
M
S
P
I
R
C
T
Q
N
P
S
M
G
E
E
W
R
R
-----
G
W
HPER
I
-----
R
-
A
K
E
S
D
A
R
V
L
V
V
G
A
G
P
S
G
L
E
A
A
R
A
L
G
V
R
G
Y
D
V
V
L
A
E
A
G
R
D
L
G
G
R
V
T
Q
E
S
A
L
P
G
L
S
A
--
W
G
R
V
K
E
Y
R
E
A
-
V
L
A
E
L
P
-----
N
V
E
I
Y
R
---
E
-
S
P
M
T
G
D
D
I
V
E
F
G
F
E
H
V
I
T
A
T
G
A
T
W
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
HHSearch
45.83
29%
-18
- C7 -
-
3HGJ
2
?
A:
[2-345]
-----
A
L
L
F
T
P
L
E
L
G
G
L
R
L
K
N
R
L
--
A
M
S
--
P
M
C
Q
Y
S
A
T
L-
E
G
E
V
T
D
W
--
H
L
L
H
Y
P
T
-
R
A
L
G
G
V
G
L
I
L
V
E
A
--
T
A
V
E
P
L
G
R
I
-
S
-
P
-
Y
D
L
G
-
I
W
S
E
D
-------
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
K
-------
A
------
G
T
------
A
RPWEGGKPLGW
R
----
V
V
G
P
S
P
I
-
P
-
F
D
---------------
E
------------
G
Y
P
V
P
E
P
L
D
E
A
G
M
E
R
I
L
----
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
-
L
-
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
P
R
E
L
P
L
F
V
R
V
S
A
T
D
W
-
G
E
---
G
G
W
S
L
E
---
D
T
L
A
F
A
R
R
L
K
E
L
------
G
--
V
D
L
L
D
C
S
-
S
G
----
G
V
V
L
R
V
R
I
-----
P
--
L
A
P
G
F
Q
V
---
P
F
A
D
A
V
R
K
R
V
G
L
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
Q
A
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
P
E
V
P
P
Q
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
45.58
26%
17
- C8 -
-
1O94
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
H
--
C
I
G
A
G
S
D
K
--
P
G
F
Q
------
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
--------
P
-
E
S
D
D
-
T
H
R
L
S
A
R
IWD
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
---------
A
------
H
A
------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
-
G
P
SQY------------
A
------------
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
-
V
D
T
-
V
Y
---
G
P
G
Q
I
E
---
A
E
V
D
G
Q
K
F
V
E
M
A
------
D
SL
V
D
M
W
D
I
T
-
I
G
D
IAE
W
G
E
D
A
G
P
S
-
R
-
F
Y
Q
----
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
I
-
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
GWHPE
K
F
----
R
-----
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
WS
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
-
K
-----
N
K
E
S
Q
L
A
L
G
Q
-
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-----------
R
--------
W
N
T
D
G
T
N
C
LTHDPIPGADASL
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
45.29
26%
10
- C8 -
-
1O95
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
H
--
C
I
G
A
G
S
D
K
--
P
G
F
Q
------
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
--------
P
-
E
S
D
D
-
T
H
R
L
S
A
R
IWD
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
---------
A
------
H
A
------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
-
G
P
S
Q
Y
------------
A
------------
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
-
V
D
T
-
V
Y
---
G
P
G
Q
I
E
---
A
E
V
D
G
Q
K
F
V
E
M
A
------
D
SL
V
D
M
W
D
I
T
-
I
G
D
IAE
W
G
E
D
A
G
P
S
-
R
-
F
Y
Q
----
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
I
-
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
GWHPE
K
F
----
R
-----
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
WS
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
-
K
-----
N
K
E
S
Q
L
A
L
G
Q
-
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-----------
R
--------
W
N
T
D
G
T
N
C
LTHDPIPGADASL
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
45.11
26%
20
- C8 -
-
2TMD
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
H
--
C
I
G
A
G
S
D
K
--
P
G
F
Q
------
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
--------
P
-
E
S
D
D
-
T
H
R
L
S
A
R
IWD
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
---------
A
------
H
A
------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
-
G
P
SQY------------
A
------------
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
-
V
D
T
-
V
Y
---
G
P
G
Q
I
E
---
A
E
V
D
G
Q
K
F
V
E
M
A
------
D
SL
V
D
M
W
D
I
T
-
I
G
D
IAE
W
G
E
D
A
G
P
S
-
R
-
F
Y
Q
----
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
I
-
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
GWHPE
K
F
----
R
-----
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
WS
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
-
K
-----
N
K
E
S
Q
L
A
L
G
Q
-
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-----------
R
--------
W
N
T
D
G
T
N
C
LTHDPIPGADASL
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
44.96
26%
18
- C8 -
-
1DJN
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
H
--
C
I
G
A
G
S
D
K
--
P
G
F
Q
------
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
--------
P
-
E
S
D
D
-
T
H
R
L
S
A
R
IWD
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
---------
A
------
H
A
------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
-
G
P
S
Q
Y
------------
A
------------
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
-
V
D
T
-
V
Y
---
G
P
G
Q
I
E
---
A
E
V
D
G
Q
K
F
V
E
M
A
------
D
SL
V
D
M
W
D
I
T
-
I
G
D
IAE
W
G
E
D
A
G
P
S
-
R
-
F
Y
Q
----
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
I
-
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
GWHPE
K
F
----
R
-----
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
WS
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
-
K
-----
N
K
E
S
Q
L
A
L
G
Q
-
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-----------
R
--------
W
N
T
D
G
T
N
C
LTHDPIPGADASL
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
44.84
26%
19
- C8 -
-
1DJQ
3
DHTM_METME
A:
[9-536]
-------
L
F
E
P
I
Q
I
G
P
K
T
L
R
N
R
F
Y
Q
V
P
H
--
A
I
G
A
G
S
D
K
--
P
G
F
Q
------
S
A
H
R
S
V
-
K
A
E
G
G
W
A
A
L
N
T
E
Y
--
C
S
I
N
--------
P
-
E
S
D
D
-
T
H
R
L
S
A
R
IWD
E
G
D
V
R
N
L
K
A
M
T
D
E
V
H
K
Y
G
A
L
A
G
V
E
L
W
Y
G
G
---------
A
------
H
A
------
P
-----------
N
----
M
E
S
R
A
T
P
-
R
-
G
P
SQY------------
A
------------
S
E
F
E
T
L
S
Y
C
K
E
M
D
L
S
D
I
A
Q
V
Q
Q
F
Y
V
D
A
A
K
R
S
R
D
A
G
F
D
I
V
Y
V
Y
G
A
H
S
Y
-
L
-
P
L
Q
F
L
N
P
Y
Y
N
K
R
T
D
K
Y
G
G
S
L
E
N
R
A
R
F
W
L
E
T
L
E
K
V
K
H
A
V
G
S
D
C
A
I
A
T
R
F
G
-
V
D
T
-
V
Y
---
G
P
G
Q
I
E
---
A
E
V
D
G
Q
K
F
V
E
M
A
------
D
SL
V
D
M
W
D
I
T
-
I
G
D
IAE
W
G
E
D
A
G
P
S
-
R
-
F
Y
Q
----
Q
G
H
T
I
---
P
W
V
K
L
V
K
Q
V
S
K
K
P
V
L
G
V
G
R
Y
T
D
P
E
K
M
I
E
I
V
T
K
G
Y
A
D
I
I
G
C
A
R
P
S
I
A
D
P
F
L
P
Q
K
V
E
Q
G
R
Y
D
D
I
R
V
C
I
G
C
N
V
C
I
S
R
W
E
I
-
G
G
P
P
M
I
C
T
Q
N
A
T
A
G
E
E
Y
R
R
GWHPE
K
F
----
R
-----
Q
-
T
K
N
K
D
-
S
V
L
I
V
G
A
G
P
S
G
S
E
A
A
R
V
L
M
E
S
G
Y
T
V
H
L
T
D
T
A
E
K
I
G
G
H
L
N
Q
V
A
A
L
P
G
L
G
E
WS
Y
H
R
D
Y
R
E
T
Q
I
T
K
L
L
K
-
K
-----
N
K
E
S
Q
L
A
L
G
Q
-
K
P
M
T
A
D
D
V
L
Q
Y
G
A
D
K
V
I
I
A
T
G
A
-----------
R
--------
W
N
T
D
G
T
N
C
LTHDPIPGADASL
P
--------
D
Q
L
T
P
E
Q
V
M
D
G
K
K
K
-
I
G
K
R
V
V
I
L
N
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
HHSearch
43.80
24%
-41
- C7 -
-
5DXX
1
DBR2_ARTAN
A:
[4-364]
----
K
P
T
L
F
S
A
Y
K
M
G
K
F
N
L
S
H
R
V
--
V
L
A
--
P
M
T
R
C
R
A
I
--
N
A
I
P
N
E
A
--
L
V
E
Y
Y
R
Q
-
R
S
T
A
G
-
G
F
L
I
T
E
G
--
T
M
I
S
P
S
S
A
G
-
F
-
P
-
H
V
P
G
-
I
F
T
K
E
-------
Q
V
E
G
W
K
K
V
V
D
A
A
H
K
E
G
A
V
I
F
C
Q
L
W
H
V
G
R
A
-------
S
------
H
Q
------
V
YQPGGA-----
A
----
P
I
S
S
T
S
K
-
P
-
I
S
---------------
K
K
W
E
I
L
L
PDA
T
Y
G
T
Y
P
E
P
R
P
L
A
A
N
E
I
L
E
V
V
----
E
D
Y
R
V
A
A
I
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
-
L
-
L
D
Q
F
M
K
D
G
I
N
D
R
T
D
E
Y
G
G
S
L
E
N
R
C
K
F
I
L
Q
V
V
Q
A
V
S
A
A
I
G
T
-
D
R
V
G
I
R
I
S
P
A
I
D
-
H
T
---
D
A
M
D
S
D
P
R
S
L
G
L
A
V
I
E
R
L
N
K
L
Q
F
K
L
GS---
L
A
Y
L
H
V
T
-
Q
P
----
R
Y
T
A
D
G
H
G
-
Q
-
T
E
--------
E
E
E
V
A
Q
L
M
K
T
W
R
G
A
Y
V
G
T
F
I
C
C
G
G
Y
-
T
R
E
L
G
L
Q
A
V
A
Q
G
D
A
D
L
V
A
F
G
R
Y
F
V
S
N
P
D
L
V
L
R
L
K
L
N
A
P
L
N
R
--
Y
D
R
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
42.49
30%
-1
- C7 -
-
1Z41
1
NAMA_BACSU
A:
[4-328]
------
K
L
F
T
P
I
T
I
K
D
M
T
L
K
N
R
I
--
V
M
S
PM
C
M
Y
S
S
H
E
K
--
D
G
K
L
T
P
F
--
H
M
A
H
Y
I
S
-
R
A
I
G
Q
V
G
L
I
I
V
E
A
--
S
A
V
N
P
Q
G
R
I
-
T
-
D
-
Q
D
L
G
-
I
W
S
D
E
-------
H
I
E
G
F
A
K
L
T
E
Q
V
K
E
Q
G
S
K
I
G
I
Q
L
A
H
A
G
R
K
-------
A
E-----
L
E
------
G
-----------
D
----
I
F
A
P
S
A
I
-
A
-
F
D
---------------
E
------------
Q
S
A
T
P
V
E
M
S
A
E
K
V
K
E
T
V
----
Q
E
F
K
Q
A
A
A
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
H
E
F
L
S
P
L
S
N
H
R
T
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
R
E
I
I
D
E
V
K
Q
V
W
D
G
P
L
F
V
--
R
V
S
A
S
D
Y
-
T
D
---
K
G
L
D
I
A
---
D
H
I
G
F
A
K
W
M
K
E
Q
------
G
--
V
D
L
I
D
C
S
-
S
G
-------
A
L
V
H
A
-
D
-
I
N
V
--
F
P
-
G
Y
Q
V
---
S
F
A
E
K
I
R
E
Q
A
D
M
A
T
G
A
V
G
M
I
T
D
G
S
M
A
E
E
I
L
Q
N
G
R
A
D
L
I
F
I
G
R
E
L
L
R
D
P
F
F
A
R
T
A
A
K
Q
L
N
T
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
42.35
31%
-2
- C7 -
-
2GQA
1
?
A:
[4-328]
------
S
L
F
Q
P
I
T
L
G
A
L
T
L
K
N
R
I
--
V
M
P
--
P
M
T
R
S
R
A
S
--
Q
P
G
D
V
A
N
H
M
M
A
I
Y
Y
A
Q
-
R
A
S
A
G
--
L
I
V
S
E
G
TQ
I
S
P
T
A
K
G
Y
A
-
W
-
T
-
P
G
---
I
Y
T
P
E
-------
Q
I
A
G
W
R
I
V
T
E
A
V
H
A
K
G
C
A
I
F
A
Q
L
W
H
V
G
R
V
THPDNID
G
------
Q
Q
------
P
-----------------
I
S
S
S
T
L
-
K
-
A
E
N
V
K
V
F
V
D
N
GSD
E
P
G
F
V
------------
D
V
A
V
P
R
A
M
T
K
A
D
I
A
Q
V
I
----
A
D
Y
R
Q
A
A
L
N
A
M
E
A
G
F
D
G
I
E
L
H
A
A
N
G
Y
-
L
-
I
N
Q
F
I
D
S
E
A
N
N
R
S
D
E
Y
G
G
S
L
E
N
R
L
R
F
L
D
E
V
V
A
A
L
V
D
A
I
G
A
E
R
-
V
G
V
R
L
A
P
L
T
T
-
L
N
G
T
V
D
A
D
P
I
L
---
T
Y
T
A
A
A
A
L
L
N
K
H
------
R
--
I
V
Y
L
H
I
A
E
V
D
----
W
D
D
A
--
P
D
-
T
-
P
V
S
--
F
K
R
A
-----------
L
R
E
A
Y
Q
G
V
L
I
Y
A
G
R
Y
N
A
-
E
K
A
E
Q
A
I
N
D
G
L
A
D
M
I
G
F
G
R
P
F
I
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
42.06
31%
-4
- C7 -
-
4AWU
5
?
A:
[4-328]
------
S
L
F
Q
P
I
T
L
G
A
L
T
L
K
N
R
I
--
V
M
P
--
P
L
T
R
S
R
A
S
--
Q
P
G
D
V
A
N
H
M
M
A
I
Y
Y
A
Q
-
R
A
S
A
G
--
L
I
V
S
E
G
T
Q
I
S
P
T
A
K
G
Y
A
-
W
-
T
-
P
G
---
I
Y
T
P
E
-------
Q
I
A
G
W
R
I
V
T
E
A
V
H
A
K
G
C
A
I
F
A
Q
L
W
H
V
G
R
V
THPDNID
G
------
Q
Q
------
P
-----------------
I
S
S
S
T
L
-
K
-
A
E
N
V
K
V
F
V
DNGSDE
P
G
F
V
------------
D
V
A
V
P
R
A
M
T
K
A
D
I
A
Q
V
I
----
A
D
Y
R
Q
A
A
L
N
A
M
E
A
G
F
D
G
I
E
L
H
A
A
N
G
Y
-
L
-
I
N
Q
F
I
D
S
E
A
N
N
R
S
D
E
Y
G
G
S
L
E
N
R
L
R
F
L
D
E
V
V
A
A
L
V
D
A
I
G
A
E
R
-
V
G
V
R
L
A
P
L
T
T
-
L
N
G
T
V
D
A
D
P
I
L
---
T
Y
T
A
A
A
A
L
L
N
K
H
------
R
--
I
V
Y
L
H
I
A
E
V
D
----
W
D
D
A
--
P
D
-
T
-
P
V
S
--
F
K
R
A
-----------
L
R
E
A
Y
Q
G
V
L
I
Y
A
G
R
Y
N
A
-
E
K
A
E
Q
A
I
N
D
G
L
A
D
M
I
G
F
G
R
P
F
I
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
41.96
31%
-3
- C7 -
-
2GOU
4
?
A:
[4-328]
------
S
L
F
Q
P
I
T
L
G
A
L
T
L
K
N
R
I
--
V
M
P
--
P
M
T
R
S
R
A
S
--
Q
P
G
D
V
A
N
H
M
M
A
I
Y
Y
A
Q
-
R
A
S
A
G
--
L
I
V
S
E
G
TQ
I
S
P
T
A
K
G
Y
A
-
W
-
T
-
P
G
---
I
Y
T
P
E
-------
Q
I
A
G
W
R
I
V
T
E
A
V
H
A
K
G
C
A
I
F
A
Q
L
W
H
V
G
R
V
THPDNID
G
------
Q
Q
------
P
-----------------
I
S
S
S
T
L
-
K
-
A
E
N
V
K
V
F
V
D
N
GSD
E
P
G
F
V
------------
D
V
A
V
P
R
A
M
T
K
A
D
I
A
Q
V
I
----
A
D
Y
R
Q
A
A
L
N
A
M
E
A
G
F
D
G
I
E
L
H
A
A
N
G
Y
-
L
-
I
N
Q
F
I
D
S
E
A
N
N
R
S
D
E
Y
G
G
S
L
E
N
R
L
R
F
L
D
E
V
V
A
A
L
V
D
A
I
G
A
E
R
-
V
G
V
R
L
A
P
L
T
T
-
L
N
G
T
V
D
A
D
P
I
L
---
T
Y
T
A
A
A
A
L
L
N
K
H
------
R
--
I
V
Y
L
H
I
A
E
V
D
----
W
D
D
A
--
P
D
-
T
-
P
V
S
--
F
K
R
A
-----------
L
R
E
A
Y
Q
G
V
L
I
Y
A
G
R
Y
N
A
-
E
K
A
E
Q
A
I
N
D
G
L
A
D
M
I
G
F
G
R
P
F
I
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
41.92
31%
-2
- C7 -
-
2GQ8
4
?
A:
[4-328]
------
S
L
F
Q
P
I
T
L
G
A
L
T
L
K
N
R
I
--
V
M
P
--
P
M
T
R
S
R
A
S
--
Q
P
G
D
V
A
N
H
M
M
A
I
Y
Y
A
Q
-
R
A
S
A
G
--
L
I
V
S
E
G
TQ
I
S
P
T
A
K
G
Y
A
-
W
-
T
-
P
G
---
I
Y
T
P
E
-------
Q
I
A
G
W
R
I
V
T
E
A
V
H
A
K
G
C
A
I
F
A
Q
L
W
H
V
G
R
V
THPDNID
G
------
Q
Q
------
P
-----------------
I
S
S
S
T
L
-
K
-
A
E
N
V
K
V
F
V
D
NGSD
E
P
G
F
V
------------
D
V
A
V
P
R
A
M
T
K
A
D
I
A
Q
V
I
----
A
D
Y
R
Q
A
A
L
N
A
M
E
A
G
F
D
G
I
E
L
H
A
A
N
G
Y
-
L
-
I
N
Q
F
I
D
S
E
A
N
N
R
S
D
E
Y
G
G
S
L
E
N
R
L
R
F
L
D
E
V
V
A
A
L
V
D
A
I
G
A
E
R
-
V
G
V
R
L
A
P
L
T
T
-
L
N
G
T
V
D
A
D
P
I
L
---
T
Y
T
A
A
A
A
L
L
N
K
H
------
R
--
I
V
Y
L
H
I
A
E
V
D
----
W
D
D
A
--
P
D
-
T
-
P
V
S
--
F
K
R
A
-----------
L
R
E
A
Y
Q
G
V
L
I
Y
A
G
R
Y
N
A
-
E
K
A
E
Q
A
I
N
D
G
L
A
D
M
I
G
F
G
R
P
F
I
A
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
HHSearch
41.85
30%
-14
- C7 -
-
3GR8
2
NAMA_GEOKA
B:
[1-334]
---
M
N
T
M
L
F
S
P
Y
T
I
R
G
L
T
L
K
N
R
I
--
V
M
S
--
P
M
C
M
Y
S
C
D
TK
D
G
A
V
R
T
W
--
H
K
I
H
Y
P
A
-
R
A
V
G
Q
V
G
L
I
I
V
E
A
--
T
G
V
T
P
Q
G
R
I
-
S
-
E
-
R
D
L
G
-
I
W
S
D
D
-------
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
K
-------
S
------
Q
V
------
P
G----------
E
----
I
I
A
P
S
A
V
-
P
-
F
D
---------------
D
------------
S
S
P
T
P
K
E
M
T
K
A
D
I
E
E
T
V
----
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
-
L
-
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
S
P
E
N
R
Y
R
F
L
G
E
V
I
D
A
V
R
E
V
W
--
D
G
P
L
F
V
R
I
S
A
S
D
Y
-
H
P
---
D
G
L
T
A
K
---
D
Y
V
P
Y
A
K
R
M
K
E
Q
------
G
--
V
D
L
V
D
V
S
-
S
G
----
A
I
V
P
A
R
------
M
N
--
V
Y
P
G
Y
Q
V
---
P
F
A
E
L
I
R
R
E
A
D
I
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
Q
N
G
R
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
P
Y
A
A
A
R
E
L
G
A
K
I
S
A
P
V
Q
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------