@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VS15: (2017-12-05 )
MILKRLIGLFSPDLAIDLGTANTLIYAPGRGIILNEPTVVAIRHSGSQKIVAAVGLDAKQMLGRTPANISAIRPMKDGVIADFEVTETMLNQFIGKVHEKRLFPPAPRVVVCVPCKSTLVERRAIREAVFNASARDVRLIEEPMAAAIGAGMPVEQACGSMVVDVGGGTTEIAIISLQGCVYADSLRIGGDVFDEQIINYVRKAHGCVIGETTAEIIKKEVGMAVSDGTTLEIEVRGRNLAEGVPRAITVTSDEITQAISDPLQSIVSAVKSALEQTPPELSSDIAERGIVLTGGGALLRNLDKLLAQETGLPVVVAEDPLTCVTRGGGKVLEFFDDPNHDMLFVG
Atome Classification :
(21 SA)
.........10........20...-.....30--..------......40.-.......50........60........70...-.--------....80........90........-100.......110.......120.......130.......140.......150.......160.......170.......180-----.......190.......200---........210-----------.........220--...--....230-.--......--.240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
L
K
R
L
I
G
LFSPD
L
A
I
D
LGTA
N
T
L
-
I
YAPG
R
G
--
I
I
------LNEP
T
V
V
A
I
-RHSGS
Q
K
I
V
A
A
VGL
D
A
K
Q
M
LGRTPANI
S
A
IRP-M--------KDG
V
I
A
D
F
E
V
T
E
T
M
L
N
Q
F
I
G
K
V
H
E-KRLFPPA
P
R
V
V
V
C
V
P
C
K
S
T
L
V
E
R
R
A
I
R
E
A
V
FNASARD
V
R
L
I
E
E
P
M
A
A
AIGAGM
P
V
E
Q
ACG
S
M
V
V
DVGGG
T
T
E
I
A
I
I
S
LQG
C
V
Y
-----ADSLRIG
G
D
V
F
D
E
Q
I
I
N
Y
V
----
R
K
AHGCVIG-------------
E
T
T
A
E
I
I
K
K
E
VG--MAV--SDG
T
T
L
--
E
--
I
E
V
RGR--
N
L
AEGVP
R
A
I
T
V
T
S
D
E
I
T
Q
A
I
S
D
P
L
Q
S
I
V
S
A
V
K
S
A
L
E
QTP
P
E
L
S
S
D
I
A
ER
G
I
V
L
TG
G
G
A
L
L
R
N
L
D
K
L
L
A
QETGL
P
V
V
VAEDP
L
T
C
V
TRGG
G
K
V
L
E
FFDDPNH
D
M
L
F
VG
21
PsiBlast_CBE
85.66
60%
-41
- C1 -
-
4CZJ
1
?
B:
[5-327]
------------
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
--------
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP
A
D
G
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
3
PsiBlast_PDB
85.21
60%
-42
- C1 -
-
4CZG
2
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP----
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
6
PsiBlast_PDB
85.12
60%
-44
- C1 -
-
4CZJ
1
?
A:
[5-327]
------------
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
--------
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP---
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
1
PsiBlast_PDB
84.36
60%
-34
- C1 -
-
4CZE
-
?
A:
[3-326]
----------
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
G
F
V
-
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP---
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
-------------
22
PsiBlast_CBE
83.84
59%
-44
- C1 -
-
4CZM
1
?
B:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP
A
D
G
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
8
PsiBlast_PDB
83.75
59%
-39
- C1 -
-
4CZL
1
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
------
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP
A
D
G
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
2
PsiBlast_PDB
83.72
60%
-43
- C1 -
-
4CZF
1
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
----
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP----
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
9
PsiBlast_PDB
82.74
59%
-33
- C1 -
-
4CZM
1
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP
A
D
G
E
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
4
PsiBlast_PDB
82.40
60%
-38
- C1 -
-
4CZH
2
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP----
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
5
PsiBlast_PDB
81.96
60%
-43
- C1 -
-
4CZI
-
?
A:
[9-334]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
----
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
--
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP----
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
7
PsiBlast_PDB
81.57
60%
-34
- C1 -
-
4CZK
2
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
-
I
Y
Q
K
G
K
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
----
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
AP----
G
L
--
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
37
HHSearch
80.34
59%
-5
* C1 *
-
4CZG
2
?
A:
[2-327]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
--
A
P
------
G
L
S
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
------------
38
HHSearch
78.99
59%
-5
- C1 -
-
4CZM
1
?
A:
[2-328]
---------
I
S
N
D
I
A
I
D
L
G
T
A
N
T
L
I
Y
Q
K
G
K
-
G
--
I
V
------
L
N
E
P
S
V
V
A
L
-
R
N
V
G
G
R
K
V
V
H
A
V
G
I
E
A
K
Q
M
L
G
R
T
P
G
H
M
E
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
F
E
V
A
E
E
M
I
K
Y
F
I
R
K
V
H
N
-
R
K
-
G
S
G
N
P
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
L
N
A
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
G
A
G
L
P
I
H
E
P
T
G
S
M
V
V
D
I
G
G
G
T
T
E
V
A
V
L
S
L
S
G
I
V
Y
-----
S
R
S
V
R
V
G
G
D
K
M
D
E
A
I
I
S
Y
M
----
R
R
H
H
N
L
L
I
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
--
T
A
R
--
A
P
A
D
G
E
G
L
S
--
I
D
V
K
G
R
--
D
L
M
Q
G
V
P
R
E
V
R
I
S
E
K
Q
A
A
D
A
L
A
E
P
V
G
Q
I
V
E
A
V
K
V
A
L
E
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
L
P
V
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
E
H
P
-----------
12
PsiBlast_PDB
77.73
51%
-
- C1 -
-
2WUS
-
?
A:
[2-324]
---------
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
G
K
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
T
G
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
S
--
K
E
N
D
E
L
--
E
--
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
-------------
10
PsiBlast_PDB
76.95
51%
-26
- C1 -
-
1JCF
-
?
A:
[1-324]
--------
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
G
K
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
T
G
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
S
--
K
E
N
D
E
L
--
E
--
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
-------------
11
PsiBlast_PDB
76.05
51%
-31
- C1 -
-
1JCG
1
?
A:
[1-324]
--------
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
G
K
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
T
G
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
S
--
K
E
N
D
E
L
--
E
--
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
-------------
13
PsiBlast_PDB
74.21
49%
-23
- C1 -
-
1JCE
-
?
A:
[4-324]
-----------
K
D
I
G
I
D
L
G
T
A
N
T
L
-
V
F
L
R
G
K
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
T
G
E
--
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
G
M
N
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
S
--
K
E
N
D
E
L
--
E
--
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
-------------
40
HHSearch
73.14
50%
-5
- C1 -
-
1JCF
-
?
A:
[1-328]
--------
M
L
R
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
--
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
-
G
M
-
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
--
N
V
F
--
P
S
K
E
N
D
--
E
L
E
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
---------
39
HHSearch
70.92
50%
-5
- C1 -
-
1JCE
-
?
A:
[4-328]
-----------
K
D
I
G
I
D
L
G
T
A
N
T
L
V
F
L
R
G
K
-
G
--
I
V
------
V
N
E
P
S
V
I
A
I
-
D
S
T
--
T
G
E
I
L
K
V
G
L
E
A
K
N
M
I
G
K
T
P
A
T
I
K
A
I
R
P
-
M
--------
R
D
G
V
I
A
D
Y
T
V
A
L
V
M
L
R
Y
F
I
N
K
A
K
G
-
G
M
-
N
L
F
K
P
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
L
E
A
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
G
S
N
L
N
V
E
E
P
S
G
N
M
V
V
D
I
G
G
G
T
T
E
V
A
V
I
S
L
G
S
I
V
T
-----
W
E
S
I
R
I
A
G
D
E
M
D
E
A
I
V
Q
Y
V
----
R
E
T
Y
R
V
A
I
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
--
N
V
F
--
P
S
K
E
N
D
--
E
L
E
T
T
V
S
G
I
--
D
L
S
T
G
L
P
R
K
L
T
L
K
G
G
E
V
R
E
A
L
R
S
V
V
V
A
I
V
E
S
V
R
T
T
L
E
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
I
S
V
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
N
I
---------
44
HHSearch
58.63
25%
-
- C1 -
-
4ANI
-
DNAK_GEOKA
C:
[2-353]
----------
S
K
I
I
G
I
D
L
G
T
T
N
S
C
V
A
V
L
E
G
G
E
V
K
V
I
P
N
PEGN
R
T
T
P
S
V
V
A
F
-
K
N
-----
G
E
R
L
V
G
E
V
A
K
R
Q
A
I
T
N
P
N
T
I
I
S
I
K
R
H
M
GTD
Y
K
V
E
I
E
G
K
Q
Y
T
P
Q
E
I
S
A
I
I
L
Q
Y
L
K
S
Y
A
E
D
-
Y
L
-
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
----
V
N
Q
F
K
Q
E
H
G
IDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
--
G
V
T
--
Q
T
Q
I
--------
S
L
P
F
I
SA
N
E
N
G
P
L
H
L
E
M
T
L
T
R
A
K
F
E
E
L
S
A
H
L
V
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
---
P
A
D
I
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
K
E
P
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
A
G
---------
15
PsiBlast_PDB
25.67
31%
-1
- C1 -
-
2V7Y
1
DNAK_GEOKA
A:
[55-218]
------------------------------
R
Q
--
A
I
------
T
N
P
N
T
I
I
S
I
K
R
H
M
G
T
D
---
Y
K
V
E
I
E
G
K
Q
Y
---
T
P
Q
E
I
S
A
I
--------------------------
I
L
Q
Y
L
K
S
Y
A
E
-
D
Y
L
G
E
P
V
T
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
R
I
A
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
A
Y
G
L
D
K
E
E
D
Q
T
I
L
V
Y
D
L
G
G
G
T
F
D
V
S
I
L
E
L
G
D
G
V
F
E
V
K
A
T
A
G
D
N
H
L
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
Q
E
H
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------