@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VUS0: (2017-12-20 )
MINIQNTILGKIVDRKHEDLAARLKQRNLQDVEELAKAATPVRGFANALQHKRPGVIAEIKKASPSKGIIRADFNPAEIAQQYEQAGAACLSVLTDVDFFQGADENIAIARNHCTLPALRKDFLVDPYNVVEARALHADCILLIVACLSDQQLEEMSKTAFEHQLDVLVEVHDEEELERALKLSEQCLLGVNNRNLKTFDVDLNTTIRLKKLLPASRLLITESGIATPDDVRMMQEHDIHSFLVGESFMKQPRPDQAFTALFGQPQTV
Atome Classification :
(22 SA)
.........10........20........30........40........50---.....----....60........70........80........90......-..100.......110.......120.......130.-......140.......150-.........160.......170-.......180.......190.......--200.......210..---.---....220.......230.......240.......250..--.....260......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MIN
I
Q
N
T
I
L
G
K
I
V
DR
K
H
E
D
L
A
A
R
L
K
QR
N
L
Q
D
V
E
E
L
A
K
AAT
P
V
R
G
F
A
N
A
L
Q
----HKRP
G
----
V
I
A
E
I
KKASPSK
G
I
I
RADF
N
P
A
E
I
A
Q
Q
Y
E
Q
A
G
A
A
C
L
S
V
L
T
D
V
-
D
F
FQGADE
N
I
A
I
ARNHCT
L
P
A
L
R
K
D
FLVD
P
Y
N
V
V
E
A
-
R
A
L
H
A
D
C
I
L
L
I
V
A
CL
S
D
---
Q
Q
L
E
E
M
S
K
T
A
F
E
H
Q
L
D
V
L
VEVH-
D
E
E
E
L
E
R
A
L
K
L
S
E
Q
C
LLGVNNR
N
L
K
T
F
--
D
V
DLN
T
T
I
R
L
KKLLP---A---
S
R
L
L
I
TESGIAT
P
D
D
V
R
M
M
Q
E
H
D
I
H
S
F
L
V
G
E
S
F
MKQPRP--
D
Q
A
F
T
A
LFGQPQTV
27
HHSearch
85.66
38%
-120
- C2 -
-
1PII
-
TRPC_ECOLI
A:
[1-255]
----
M
Q
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
Q
N
E
V
Q
--
P
S
T
R
H
F
Y
D
A
L
Q
----
G
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
-
H
Y
A
S
A
I
S
V
L
T
D
E
-
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
---
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
L
G
-
A
K
V
V
G
I
N
N
R
D
L
R
D
L
--
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
-
F
A
N
G
F
L
I
G
S
A
L
M
A
H
D
D
L
--
H
A
A
V
R
R
V
L
L
G
----
8
PsiBlast_PDB
84.94
38%
-110
- C2 -
-
3T78
1
TRPC_MYCTU
A:
[5-259]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
D
L
M
T
L
----
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
28
HHSearch
84.90
38%
-120
- C2 -
-
1JCM
1
TRPC_ECOLI
P:
[1-258]
----
M
Q
C
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
Q
N
E
V
Q
--
P
S
T
R
H
F
Y
D
A
L
Q
----
G
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
-
H
Y
A
S
A
I
S
V
L
T
D
E
-
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
---
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
L
G
-
A
K
V
V
G
I
N
N
R
D
L
C
D
L
--
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
-
F
A
N
G
F
L
I
G
S
A
L
M
A
H
D
D
L
--
H
A
A
V
R
R
V
L
L
G
E
N
K
-
26
HHSearch
82.68
49%
15
- C2 -
-
3TSM
3
TRPC_BRUA2
A:
[8-268]
------
D
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
K
A
R
T
R
D
Q
S
A
P
R
G
F
L
K
A
L
E
A
K
R
A
A
G
Q
F
A
----
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
-
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
---
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
L
S
-
S
R
L
L
G
V
N
N
R
N
L
R
S
F
--
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
--
A
A
A
T
R
A
L
L
T
G
----
7
PsiBlast_PDB
82.66
38%
-107
- C2 -
-
3T55
1
TRPC_MYCTU
A:
[5-259]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
24
HHSearch
82.23
38%
-123
- C2 -
-
3QJA
-
TRPC_MYCTU
A:
[4-262]
-----
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
-------------
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
-
A
K
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
---
23
HHSearch
82.14
37%
-108
- C2 -
-
4FB7
1
TRPC_MYCTU
A:
[7-265]
-----
A
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
-
A
K
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
T
A
G
---
6
PsiBlast_PDB
82.10
38%
-107
- C2 -
-
3T44
2
TRPC_MYCTU
A:
[5-259]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
4
PsiBlast_PDB
81.18
38%
-123
- C2 -
-
3QJA
-
TRPC_MYCTU
A:
[5-259]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
-------------
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
9
PsiBlast_PDB
80.41
37%
-108
- C2 -
-
4FB7
1
TRPC_MYCTU
A:
[8-262]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
A
S
P
S
A
G
A
L
A
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
D
L
M
T
L
--
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
25
HHSearch
80.02
49%
15
- C2 -
-
3TSM
4
TRPC_BRUA2
B:
[9-268]
-------
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
K
A
R
T
R
D
Q
S
A
P
R
G
F
L
K
A
L
E
A
K
R
A
A
G
Q
F
A
----
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
-
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
---
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
L
S
-
S
R
L
L
G
V
N
N
R
N
L
R
S
F
--
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
H
D
V
--
A
A
A
T
R
A
L
L
T
G
----
5
PsiBlast_PDB
79.38
38%
-114
- C2 -
-
3T40
1
TRPC_MYCTU
A:
[5-259]
------
T
V
L
D
S
I
L
E
G
V
R
A
D
V
A
A
R
E
A
S
V
S
L
S
E
I
K
A
A
A
A
A
A
P
P
P
L
D
V
M
A
A
L
R
----
E
P
G
I
G
----
V
I
A
E
V
K
R
---------
T
I
A
D
P
A
K
L
A
Q
A
Y
Q
D
G
G
A
R
I
V
S
V
V
T
E
Q
-
R
R
F
Q
G
S
L
D
D
L
D
A
V
R
A
S
V
S
I
P
V
L
R
K
D
F
V
V
Q
P
Y
Q
I
H
E
A
-
R
A
H
G
A
D
M
L
L
L
I
V
A
A
L
E
Q
---
S
V
L
V
S
M
L
D
R
T
E
S
L
G
M
T
A
L
V
E
V
H
-
T
E
Q
E
A
D
R
A
L
K
A
G
A
K
-
V
I
G
V
N
A
R
-------
D
V
D
R
D
C
F
A
R
I
A
P
G
L
P
---
S
---
S
V
I
R
I
A
E
S
G
V
R
G
T
A
D
L
L
A
Y
A
G
A
G
A
D
A
V
L
V
G
E
G
L
V
T
S
G
D
P
--
R
A
A
V
A
D
L
V
------
2
PsiBlast_PDB
79.13
40%
-116
- C2 -
-
1PII
-
TRPC_ECOLI
A:
[3-240]
------
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
Q
N
E
V
Q
P
S
T
--
R
H
F
Y
D
A
L
Q
----
G
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
H
Y
-
A
S
A
I
S
V
L
T
D
E
-
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
---
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
L
G
A
K
-
V
V
G
I
N
N
R
D
L
R
D
L
--
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
-
S
H
F
A
N
G
F
L
I
G
S
A
L
M
---------------------
44
Fugue
78.92
39%
-39
- C2 -
-
1PII
-
?
?:
[1-255]
----
M
Q
T
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
Q
N
E
V
Q
P
S
T
--
R
H
F
Y
D
A
L
Q
----
G
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
H
-
Y
A
S
A
I
S
V
L
T
D
E
K-
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
R
-
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
---
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
N-
E
E
E
Q
E
R
A
I
A
L
G
A
K
-
V
V
G
I
N
N
R
D
L
R
D
L
SI--
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
S
H
-
F
A
N
G
F
L
I
G
S
A
L
M
A
H
D
--D
L
H
A
A
V
R
R
V
L
L
G
----
1
PsiBlast_PDB
78.17
51%
20
- C2 -
-
3TSM
3
TRPC_BRUA2
A:
[8-255]
------
D
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
K
A
R
T
R
D
Q
S
A
P
R
G
F
L
K
A
L
E
----
A
K
R
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
-
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
---
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
L
S
S
R
-
L
L
G
V
N
N
R
N
L
R
S
F
--
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
-------------------
3
PsiBlast_PDB
77.44
40%
-114
- C2 -
-
1JCM
1
TRPC_ECOLI
P:
[4-240]
-------
V
L
A
K
I
V
A
D
K
A
I
W
V
E
A
R
K
Q
Q
Q
P
L
A
S
F
Q
N
E
V
Q
P
S
T
--
R
H
F
Y
D
A
L
Q
----
G
A
R
T
A
----
F
I
L
E
C
K
K
A
S
P
S
K
G
V
I
R
D
D
F
D
P
A
R
I
A
A
I
Y
K
H
Y
A
S
A
-
I
S
V
L
T
D
E
-
K
Y
F
Q
G
S
F
N
F
L
P
I
V
S
Q
I
A
P
Q
P
I
L
C
K
D
F
I
I
D
P
Y
Q
I
Y
L
A
-
R
Y
Y
Q
A
D
A
C
L
L
M
L
S
V
L
D
D
---
D
Q
Y
R
Q
L
A
A
V
A
H
S
L
E
M
G
V
L
T
E
V
S
-
N
E
E
E
Q
E
R
A
I
A
L
G
A
K
-
V
V
G
I
N
N
R
D
L
C
D
L
--
S
I
D
L
N
R
T
R
E
L
A
P
K
L
G
---
H
---
N
V
T
V
I
S
E
S
G
I
N
T
Y
A
Q
V
R
E
L
-
S
H
F
A
N
G
F
L
I
G
S
A
L
M
---------------------
21
PsiBlast_CBE
76.33
51%
19
- C2 -
-
3TSM
4
TRPC_BRUA2
B:
[9-255]
-------
I
L
R
K
I
E
A
Y
K
R
E
E
I
A
A
A
K
A
R
L
A
L
D
E
L
K
A
R
T
R
D
Q
S
A
P
R
G
F
L
K
A
L
E
----
A
K
R
A
A
G
Q
F
A
L
I
A
E
I
K
K
A
S
P
S
K
G
L
I
R
P
D
F
D
P
P
A
L
A
K
A
Y
E
E
G
G
A
A
C
L
S
V
L
T
D
T
-
P
S
F
Q
G
A
P
E
F
L
T
A
A
R
Q
A
C
S
L
P
A
L
R
K
D
F
L
F
D
P
Y
Q
V
Y
E
A
-
R
S
W
G
A
D
C
I
L
I
I
M
A
S
V
D
D
---
D
L
A
K
E
L
E
D
T
A
F
A
L
G
M
D
A
L
I
E
V
H
-
D
E
A
E
M
E
R
A
L
K
L
S
S
R
-
L
L
G
V
N
N
R
N
L
R
S
F
--
E
V
N
L
A
V
S
E
R
L
A
K
M
A
P
---
S
---
D
R
L
L
V
G
E
S
G
I
F
T
H
E
D
C
L
R
L
E
K
S
G
I
G
T
F
L
I
G
E
S
L
M
R
Q
-------------------
29
HHSearch
75.96
36%
-81
- C2 -
-
1VC4
4
?
B:
[6-253]
--
S
R
V
P
G
V
L
G
E
I
A
R
K
R
A
S
E
V
A
P
Y
P
L
P
-----------
E
P
P
S
V
P
S
F
K
E
A
L
L
----
R
P
G
L
S
----
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
E
-
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
-
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
-
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
----
E
L
T
G
A
Y
L
E
E
A
R
R
L
G
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
A
G
-
A
E
V
L
G
I
N
N
R
D
L
A
T
L
--
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
KRG
F
---
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
E
G
-
L
F
D
A
V
L
I
G
T
S
L
M
R
A
P
D
L
--
E
A
A
L
R
E
L
V
------
15
PsiBlast_PDB
69.24
30%
-108
- C2 -
-
1LBL
1
TRPC_SULSO
A:
[46-245]
----------------------------------------------------------
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
-
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
---
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
I
G
A
R
-
F
I
G
I
N
S
R
D
L
E
T
L
--
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
P
E
K
--
I
K
E
F
----------
16
PsiBlast_PDB
69.22
30%
-110
- C2 -
-
1A53
1
TRPC_SULSO
A:
[46-245]
----------------------------------------------------------
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
-
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
---
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
I
G
A
R
-
F
I
G
I
N
S
R
D
L
E
T
L
--
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
P
E
K
--
I
K
E
F
----------
19
PsiBlast_PDB
67.76
30%
-107
- C2 -
-
1JUL
1
TRPC_SULSO
A:
[47-246]
----------------------------------------------------------
A
----
I
I
A
E
Y
K
R
K
S
P
S
G
L
D
V
E
R
D
--
P
I
E
Y
S
K
F
M
E
R
Y
-
A
V
G
L
S
I
L
T
E
E
-
K
Y
F
N
G
S
Y
E
T
L
R
K
I
A
S
S
V
S
I
P
I
L
M
K
D
F
I
V
K
E
S
Q
I
D
D
A
-
Y
N
L
G
A
D
T
V
L
L
I
V
K
I
L
T
E
---
R
E
L
E
S
L
L
E
Y
A
R
S
Y
G
M
E
P
L
I
E
I
N
-
D
E
N
D
L
D
I
A
L
R
I
G
A
R
-
F
I
G
I
N
S
R
D
L
E
T
L
--
E
I
N
K
E
N
Q
R
K
L
I
S
M
I
P
---
S
---
N
V
V
K
V
A
E
S
G
I
S
E
R
N
E
I
E
E
L
R
K
L
G
V
N
A
F
L
I
G
S
S
L
M
R
N
P
E
K
--
I
K
E
F
----------
22
PsiBlast_CBE
52.67
40%
56
- C2 -
-
1VC4
4
?
B:
[43-254]
--------------------------------------------------------
R
P
G
LS--
V
I
A
E
V
K
R
Q
S
P
S
E
G
L
I
R
-
E
V
D
P
V
E
A
A
L
A
Y
A
R
G
G
A
R
A
V
S
V
L
T
E
P
-
H
R
F
G
G
S
L
L
D
L
K
R
V
R
E
A
V
D
L
P
L
L
R
K
D
F
V
V
D
P
F
M
L
E
E
A
-
R
A
F
G
A
S
A
A
L
L
I
V
A
L
L
G
E
LTG
A
Y
L
E
E
A
R
R
L
G
----
L
E
A
L
V
E
V
H
-
T
E
R
E
L
E
I
A
L
E
A
G
A
E
V
-
L
G
I
N
N
R
D
L
A
T
L
--
H
I
N
L
E
T
A
P
R
L
G
R
L
A
R
---
K
RGF
G
G
V
L
V
A
E
S
G
Y
S
R
K
E
E
L
K
A
L
-
E
G
L
F
D
A
V
L
I
G
T
S
L
M
R
A
P
D
L
--
E
A
A
L
R
E
L
V
G
-----