@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0266: (2017-12-18 )
MSSKANHAKTVICGIINVTPDSFSDGGQFFALEQALQQARKLIAEGASMLDIGGESTRPGSSYVEIEEEIQRVVPVIKAIRKESDVLISIDTWKSQVAEAALAAGADLVNDITGLMGDEKMPHVVAEARAQVVIMFNPVMARPQHPSSLIFPHFGFGQAFTEEELADFETLPIEELMEAFFERALARAAEAGIAPENILLDPGIGFGLTKKENLLLLRDLDKLHQKGYPIFLGVSRKRFVINILEENGFEVNPETELGFRNRDTASAHVTSIAARQGVEVVRVHDVASHRMAVEIASAIRLADEAENLDLKQYK
Atome Classification :
(68 SA)
.........10........20........30-........40....-----.-----...50........60........70........80..-----..-----....90........100.......110.......120......-.130.....-----..140.......150...--...--------.160------.--------.....--.170.......180.......190.......200.....-..-210.......220----....----------------...----------------.230.......240.......250.......260.......270.......280......-.290.......300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSSKANH
A
K
T
V
I
C
G
I
I
NVTPDSFSDGG
Q
F
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
AE-----G-----A
S
M
L
DIGGESTRPGS
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
RKE-----S
D
-----
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
LMGDEKM
P
H
V
V
A
EA-R
A
Q
V
V
I
M
FN-----PVMARPQHPSSLIFPHFG--FGQ--------AF
T
E
------
E
--------
E
LADF--ETL
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
EAGIAPE
N
I
L
LDPGIGFG-LT-KKE
N
L
L
L
L
R
D
L
D
-----
K
L
H
Q----------------KGY----------------
P
I
F
L
GVSR
K
R
F
V
I
N
I
LEENGFEVNPETELGFRNRDTA
S
A
H
V
T
S
I
A
A
RQG
V
E
V
V
R
V
HDVAS-
H
R
M
A
V
E
I
A
S
A
I
RLADEAENLDLKQYK
77
HHSearch
99.68
100%
-129
- C4 -
-
2VEF
-
DHPS_STRR6
A:
[7-303]
------
H
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
-----
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
-----
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
N
-----
P
V
M
A
R
P
Q
H
P
S
S
L
I
F
P
H
F
G
--
F
----------
A
F
T
----------------
E
L
A
D
F
--
E
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
G
-
L
T
-
K
K
E
N
L
L
L
L
R
D
L
D
-----
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
E
V
N
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
-
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
-----------
1
PsiBlast_PDB
99.68
100%
-129
- C4 -
-
2VEF
-
DHPS_STRR6
A:
[7-303]
------
H
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
-----
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
-----
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
N
-----
P
V
M
A
R
P
Q
H
P
S
S
L
I
F
P
H
F
G
--
F
----------
A
F
T
----------------
E
L
A
D
F
--
E
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
G
-
L
T
-
K
K
E
N
L
L
L
L
R
D
L
D
-----
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
E
V
N
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
-
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
-----------
78
HHSearch
99.05
100%
-129
- C4 -
-
2VEG
1
DHPS_STRR6
A:
[7-303]
------
H
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
-----
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
-----
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
N
-----
P
V
M
A
R
P
Q
H
P
S
S
L
I
F
P
H
F
G
--
F
----------
A
F
T
----------------
E
L
A
D
F
--
E
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
G
-
L
T
-
K
K
E
N
L
L
L
L
R
D
L
D
-----
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
E
V
N
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
-
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
-----------
2
PsiBlast_PDB
99.05
100%
-129
- C4 -
-
2VEG
1
DHPS_STRR6
A:
[7-303]
------
H
A
K
T
V
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
E
-----
G
-----
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
E
-----
S
D
-----
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
N
-----
P
V
M
A
R
P
Q
H
P
S
S
L
I
F
P
H
F
G
--
F
----------
A
F
T
----------------
E
L
A
D
F
--
E
T
L
P
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
F
G
-
L
T
-
K
K
E
N
L
L
L
L
R
D
L
D
-----
K
L
H
Q
----------------
K
G
Y
----------------
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
E
E
N
G
F
E
V
N
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
-
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
-----------
89
HHSearch
72.93
38%
-113
- C4 -
-
1AJZ
-
DHPS_ECOLI
A:
[10-278]
----
L
D
L
S
H
P
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
-----
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
-----
Q
G
--
N
P
K
T
M
Q
----------------------------------------
E
A
P
K
Y
--
D
-
D
V
F
-
A
E
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
A
-----
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
-----------
G
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
---------
60
PsiBlast_CBE
71.77
37%
-105
- C4 -
-
1AD1
1
DHPS_STAAU
A:
[1-260]
-------
T
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
E
-----
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
-----
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
L
M
H
N
--------------------------
G
N
--------
G
N
R
D
------
E
--------
P
V
---------
V
E
E
M
L
T
S
L
L
A
Q
A
-
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
-
K
T
-
R
N
E
E
A
E
V
M
A
R
L
D
-----
E
L
V
A
----------------
T
E
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
T
P
------
V
E
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
----
E
L
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
-------
69
PsiBlast_CBE
71.76
35%
-118
- C4 -
-
1AJ0
2
DHPS_ECOLI
A:
[17-277]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
-----
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
-
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
-----
Q
--------------------
G
N
--------
P
K
T
M
------
Q
--------
E
A
P
K
Y
--
D
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
A
-----
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
-----------
N
V
G
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
----------
68
PsiBlast_CBE
71.52
35%
-119
- C4 -
-
1AJ2
1
DHPS_ECOLI
A:
[17-277]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
A
-----
G
-----
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
-----
F
E
-----
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
-
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
M
-----
Q
--------------------
G
N
--------
P
K
T
M
------
Q
--------
E
A
P
K
Y
--
D
D
V
F
A
E
--
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
S
H
N
Y
S
L
L
A
R
L
A
-----
E
F
H
H
----------------
F
N
L
----------------
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
-----------
N
V
G
P
S
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
----------
87
HHSearch
70.75
38%
-121
- C4 -
-
5USW
5
?
B:
[12-280]
---
S
L
L
L
D
R
S
H
V
M
G
I
L
N
V
T
P
D
--------
T
H
-
L
D
A
A
L
K
Q
A
E
K
M
V
K
A
-----
G
-----
V
S
F
I
D
I
G
G
E
S
T
R
P
G
A
P
E
V
S
L
Q
E
E
L
D
R
V
L
P
I
I
E
A
I
H
Q
R
-----
F
D
-----
T
W
I
S
I
D
T
S
K
A
V
V
M
E
E
A
V
K
V
G
A
D
L
I
N
D
V
R
A
L
Q
-
E
P
N
A
L
K
V
A
A
E
A
-
N
V
P
V
C
L
M
H
M
-----
Q
G
--
Q
P
R
T
M
Q
----------------------------------------
T
N
P
S
Y
--
Q
-
D
L
F
-
T
D
I
S
S
F
L
S
E
R
I
D
A
C
Q
S
V
G
I
A
K
D
K
L
I
L
D
P
G
F
G
F
G
-
K
T
-
L
A
H
N
Y
Q
L
L
A
E
L
E
-----
R
F
H
Q
----------------
F
G
L
----------------
P
L
L
A
G
M
S
R
K
S
M
V
F
K
L
L
D
V
-----------
E
P
K
M
A
L
S
G
S
L
A
C
A
T
I
A
A
M
K
G
A
Q
I
I
R
V
H
D
F
E
Q
-
T
M
D
I
V
K
V
C
Q
A
T
L
E
Q
S
P
----------
64
PsiBlast_CBE
70.62
36%
-107
- C4 -
-
3TYZ
3
?
B:
[20-278]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
-----
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
---
Q
E
P
G
A
L
E
A
A
A
-
K
T
G
L
P
V
C
L
M
-----
H
M
Q
G
Q
P
K
N
M
Q
H
-----------
S
--------
P
Y
Y
D
------
D
--------
L
M
T
D
I
--
N
R
---------
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
S
-----
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
P
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------------
65
PsiBlast_CBE
70.15
36%
-104
- C4 -
-
3TYZ
3
?
A:
[20-278]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
-----
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
---
Q
E
P
G
A
L
E
A
A
A
-
K
T
G
L
P
V
C
L
M
-----
H
M
Q
G
Q
P
K
N
M
Q
H
-----------
S
--------
P
Y
Y
D
------
D
--------
L
M
T
D
I
--
N
R
---------
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
S
-----
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
P
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------------
62
PsiBlast_CBE
70.05
36%
-106
- C4 -
-
3TZF
2
?
B:
[20-278]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
-----
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
---
Q
E
P
G
A
L
E
A
A
A
-
K
T
G
L
P
V
C
L
M
-----
H
M
Q
G
Q
P
K
N
M
Q
H
-----------
S
--------
P
Y
Y
D
------
D
--------
L
M
T
D
I
--
N
R
---------
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
S
-----
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
P
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------------
85
HHSearch
70.00
36%
-118
- C4 -
-
1EYE
1
DHPS1_MYCTU
A:
[5-274]
--------
P
V
Q
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
A
-----
G
-----
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
------
Q
G
-----
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
W
-----
R
A
--
V
S
A
D
T
---
P
---
H
---------------------------------
V
P
V
R
Y
--
G
-
N
V
V
-
A
E
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
A
-
K
T
-
A
Q
H
N
W
A
I
L
H
A
L
P
-----
E
L
V
A
----------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A
G
P
D
-
G
V
M
R
----
P
T
D
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
-
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
-----------
91
HHSearch
69.56
39%
-106
- C4 -
-
1AD1
1
DHPS_STAAU
A:
[2-260]
--------
K
T
K
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
K
F
N
N
-
V
E
S
A
V
T
R
V
K
A
M
M
D
E
-----
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
I
T
V
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
-----
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
I
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
V
V
A
K
Y
-
D
A
E
I
V
L
M
H
N
-----
G
N
--
G
N
R
D
----------------------------------------------
E
----
P
V
V
-
E
E
M
L
T
S
L
L
A
Q
A
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
-
K
T
-
R
N
E
E
A
E
V
M
A
R
L
D
-----
E
L
V
A
----------------
T
E
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
G
Y
D
------
T
---
T
P
V
E
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
E
L
-
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
----------
86
HHSearch
69.55
38%
-117
- C4 -
-
5USW
3
?
A:
[12-280]
---
S
L
L
L
D
R
S
H
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
Q
F
T
H
-
L
D
A
A
L
K
Q
A
E
K
M
V
K
A
-----
G
-----
V
S
F
I
D
I
G
G
E
S
T
R
P
G
A
P
E
V
S
L
Q
E
E
L
D
R
V
L
P
I
I
E
A
I
H
Q
R
-----
F
D
-----
T
W
I
S
I
D
T
S
K
A
V
V
M
E
E
A
V
K
V
G
A
D
L
I
N
D
V
R
A
L
Q
-
E
P
N
A
L
K
V
A
A
E
A
-
N
V
P
V
C
L
M
H
M
-----
Q
G
--
Q
P
R
T
M
Q
----------------------------------------
T
N
P
S
Y
--
Q
-
D
L
F
-
T
D
I
S
S
F
L
S
E
R
I
D
A
C
Q
S
V
G
I
A
K
D
K
L
I
L
D
P
G
F
G
F
G
-
K
T
-
L
A
H
N
Y
Q
L
L
A
E
L
E
-----
R
F
H
Q
----------------
F
G
L
----------------
P
L
L
A
G
M
S
R
K
S
M
V
F
K
L
L
D
V
-----------
E
P
K
M
A
L
S
G
S
L
A
C
A
T
I
A
A
M
K
G
A
Q
I
I
R
V
H
D
F
E
Q
-
T
M
D
I
V
K
V
C
Q
A
T
L
E
Q
S
P
----------
63
PsiBlast_CBE
69.36
36%
-104
- C4 -
-
3TZF
1
?
A:
[20-278]
-----------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
-----
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
---
Q
E
P
G
A
L
E
A
A
A
-
K
T
G
L
P
V
C
L
M
-----
H
M
Q
G
Q
P
K
N
M
Q
H
-----------
S
--------
P
Y
Y
D
------
D
--------
L
M
T
D
I
--
N
R
---------
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
S
-----
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
P
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------------
57
PsiBlast_CBE
69.27
37%
-98
- C4 -
-
4HB7
6
DHPS_STAAM
A:
[5-264]
-------
T
K
T
K
I
M
G
I
L
N
V
T
----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
E
-----
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
-----
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
I
V
A
K
Y
-
D
A
E
I
I
L
M
H
N
--------------------------
G
N
--------
G
N
R
D
------
E
--------
P
V
---------
V
E
E
M
L
T
S
L
L
A
Q
A
-
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
-
K
T
-
R
N
E
E
A
E
V
M
A
R
L
D
-----
E
L
V
A
----------------
T
E
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
T
P
------
V
E
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
----
E
L
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
-------
56
PsiBlast_CBE
69.21
37%
-104
- C4 -
-
4HB7
2
DHPS_STAAM
B:
[5-264]
-------
T
K
T
K
I
M
G
I
L
N
V
T
----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
E
-----
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
-----
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
I
V
A
K
Y
-
D
A
E
I
I
L
M
H
N
--------------------------
G
N
--------
G
N
R
D
------
E
--------
P
V
---------
V
E
E
M
L
T
S
L
L
A
Q
A
-
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
-
K
T
-
R
N
E
E
A
E
V
M
A
R
L
D
-----
E
L
V
A
----------------
T
E
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
---
G
Y
D
T
T
P
------
V
E
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
----
E
L
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
-------
97
HHSearch
68.31
39%
-104
- C4 -
-
4HB7
2
DHPS_STAAM
B:
[5-264]
-------
T
K
T
K
I
M
G
I
L
N
V
T
----------
N
N
-
V
E
T
A
I
N
R
V
K
A
M
I
D
E
-----
G
-----
A
D
I
I
D
V
G
G
V
S
T
R
P
G
H
E
M
V
T
L
E
E
E
L
N
R
V
L
P
V
V
E
A
I
V
G
------
F
D
-----
V
K
I
S
V
D
T
F
R
S
E
V
A
E
A
C
L
K
L
G
V
D
M
I
N
D
Q
W
A
G
L
Y
D
H
R
M
F
Q
I
V
A
K
Y
-
D
A
E
I
I
L
M
H
N
-----
G
N
G
N
R
D
E
----------------------------------------------------
P
V
V
-
E
E
M
L
T
S
L
L
A
Q
A
H
Q
A
K
I
A
G
I
P
S
N
K
I
W
L
D
P
G
I
G
F
A
-
K
T
-
R
N
E
E
A
E
V
M
A
R
L
D
-----
E
L
V
A
----------------
T
E
Y
----------------
P
V
L
L
A
T
S
R
K
R
F
T
K
E
M
M
G
Y
D
------
T
---
T
P
V
E
R
D
E
V
T
A
A
T
T
A
Y
G
I
M
K
G
V
R
A
V
R
V
H
N
V
E
L
-
N
A
K
L
A
K
G
I
D
F
L
K
E
N
E
N
----------
13
PsiBlast_PDB
68.23
37%
-111
- C4 -
-
3H2A
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
51
PsiBlast_CBE
68.14
37%
-108
- C4 -
-
1TX0
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
9
PsiBlast_PDB
67.67
37%
-110
- C4 -
-
3H22
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
40
PsiBlast_CBE
67.31
37%
-105
- C4 -
-
3TYD
2
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
33
PsiBlast_CBE
67.29
37%
-105
- C4 -
-
4D9P
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
94
HHSearch
67.18
40%
-116
- C4 -
-
2DZA
1
?
B:
[24-286]
----
L
D
L
D
R
V
R
L
L
G
V
L
N
L
T
P
D
S
-------------
A
L
E
R
A
R
E
M
V
A
E
-----
G
-----
A
D
I
L
D
L
G
A
E
S
T
R
P
---
P
V
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
------
L
G
-----
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
-----
P
V
P
-
D
P
A
T
M
M
------
A
----------------------------------
H
A
R
Y
---
R
D
V
V
-
A
E
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
F
G
-
K
L
-
L
E
H
N
L
A
L
L
R
R
L
D
-----
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
G
V
E
----------
D
P
A
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
-
H
R
E
A
L
G
V
W
E
A
L
Y
--------------
84
HHSearch
67.03
39%
-94
- C4 -
-
2Y5S
8
?
B:
[18-292]
----
L
T
F
E
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
-----
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
-----
L
G
--
E
P
Q
T
M
Q
V
---------------------------------------
G
E
P
D
Y
--
G
-
D
V
V
-
T
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
-
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
P
-----
D
T
A
P
A
R
PDG-----------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
K
----------
P
P
L
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
-
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
----------
83
HHSearch
66.99
39%
-98
- C4 -
-
2Y5S
12
?
A:
[18-292]
----
L
T
F
E
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
-----
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
M
-----
L
G
--
E
P
Q
T
M
Q
V
---------------------------------------
G
E
P
D
Y
--
G
-
D
V
V
-
T
D
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
-
K
A
V
V
D
D
N
Y
A
L
L
A
A
L
P
-----
D
T
A
P
A
R
PDG-----------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
K
----------
P
P
L
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
-
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
----------
38
PsiBlast_CBE
66.98
37%
-102
- C4 -
-
3TYE
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
66
PsiBlast_CBE
66.92
36%
-116
- C4 -
-
3TYU
1
?
A:
[20-278]
-----------
V
M
G
I
L
N
V
T
P
D
S
------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
A
-----
G
-----
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
R
-----
F
D
-----
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
---
Q
E
P
G
A
L
E
A
A
A
-
K
T
G
L
P
V
C
L
M
-----
H
M
Q
G
----
M
Q
H
-----------
S
--------
P
Y
Y
D
------
D
--------
L
M
T
D
I
--
N
R
---------
F
F
Q
H
H
I
E
R
C
V
A
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
F
G
-
K
N
-
L
A
H
N
Y
Q
L
L
A
H
L
S
-----
E
L
H
H
----------------
F
E
L
----------------
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-----
N
V
P
P
Q
------
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
-
T
V
E
A
M
C
I
V
E
A
T
R
S
A
------------
50
PsiBlast_CBE
66.81
37%
-111
- C4 -
-
1TX2
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
37
PsiBlast_CBE
66.60
37%
-107
- C4 -
-
3TYE
2
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
-------
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
45
PsiBlast_CBE
66.59
37%
-111
- C4 -
-
3H2M
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
12
PsiBlast_PDB
66.49
37%
-100
- C4 -
-
3H26
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
61
PsiBlast_CBE
66.48
38%
-116
- C4 -
-
2DZB
1
?
B:
[28-286]
--------
R
V
R
L
L
G
V
L
N
L
T
P
D
-----------
P
E
R
A
L
E
R
A
R
E
M
V
A
E
-----
G
-----
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
L
-----
G
------
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
M
-----
P
------------
A
-
H
A
R
--
Y
R
D
--------
V
V
A
E
------------------------------
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
A
G
V
--
P
Q
V
V
L
D
P
G
F
G
F
G
-
K
L
-
L
E
H
N
L
A
L
L
R
R
L
D
-----
E
I
V
A
----------------
L
G
H
----------------
P
V
L
V
G
L
S
R
K
R
---
T
I
G
E
L
S
G
V
E
-
D
P
A
Q
----
R
V
H
G
S
V
A
A
H
L
--
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
-
H
R
E
A
L
G
V
W
E
A
L
Y
--------------
10
PsiBlast_PDB
66.34
37%
-96
- C4 -
-
3H23
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
8
PsiBlast_PDB
66.19
37%
-104
- C4 -
-
3H21
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
6
PsiBlast_PDB
66.15
37%
-104
- C4 -
-
1TX0
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
39
PsiBlast_CBE
66.12
37%
-110
- C4 -
-
3TYD
2
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
48
PsiBlast_CBE
65.96
37%
-108
- C4 -
-
3H2A
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
34
PsiBlast_CBE
65.80
37%
-110
- C4 -
-
4D8Z
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
35
PsiBlast_CBE
65.69
37%
-105
- C4 -
-
4D8Z
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
32
PsiBlast_CBE
65.67
37%
-109
- C4 -
-
4D9P
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
44
PsiBlast_CBE
65.65
37%
-105
- C4 -
-
3H2N
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
43
PsiBlast_CBE
65.44
37%
-108
- C4 -
-
3TYA
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
42
PsiBlast_CBE
65.38
37%
-105
- C4 -
-
3TYB
2
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
7
PsiBlast_PDB
65.36
37%
-100
- C4 -
-
1TX2
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
36
PsiBlast_CBE
65.29
37%
-106
- C4 -
-
4D8A
2
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
41
PsiBlast_CBE
65.25
37%
-106
- C4 -
-
3TYC
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
31
PsiBlast_CBE
65.17
37%
-106
- C4 -
-
4DAI
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
49
PsiBlast_CBE
65.04
37%
-106
- C4 -
-
3H24
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
52
PsiBlast_CBE
65.02
37%
-104
- C4 -
-
1TWZ
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
19
PsiBlast_PDB
64.88
37%
-106
- C4 -
-
3TYA
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
20
PsiBlast_PDB
64.60
37%
-104
- C4 -
-
3TYB
2
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
16
PsiBlast_PDB
64.54
37%
-99
- C4 -
-
3H2M
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
5
PsiBlast_PDB
64.53
37%
-97
- C4 -
-
1TWZ
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
4
PsiBlast_PDB
64.50
37%
-98
- C4 -
-
1TWW
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
47
PsiBlast_CBE
64.45
37%
-104
- C4 -
-
3H2C
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
-------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
30
PsiBlast_CBE
64.43
37%
-111
- C4 -
-
4DAI
1
?
B:
[39-285]
--------
K
T
L
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
29
PsiBlast_CBE
64.30
37%
-103
- C4 -
-
4DB7
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
15
PsiBlast_PDB
64.17
37%
-99
- C4 -
-
3H2F
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
17
PsiBlast_PDB
64.11
37%
-105
- C4 -
-
3H2N
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
11
PsiBlast_PDB
63.77
37%
-93
- C4 -
-
3H24
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
74
PsiBlast_CBE
63.75
36%
-96
- C4 -
-
2Y5S
12
?
A:
[22-290]
--------
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
-----
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
----
R
Q
P
G
A
I
D
A
V
-
R
D
G
N
S
G
L
C
-------
A
M
H
M
L
G
E
P
Q
T
M
Q
V
G
E
P
D
--
Y
G
D
--------
V
V
T
----------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
------------
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
K
A
V
-
V
D
D
N
Y
A
L
L
A
A
L
P
DT
A
P
A
R
P
D
G
----------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
P
P
L
E
-----
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
-
T
V
D
A
L
S
V
W
N
A
V
R
A
A
------------
18
PsiBlast_PDB
62.82
37%
-103
- C4 -
-
3H2O
1
?
A:
[39-285]
--------
K
T
L
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
E
-----
G
-----
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
E
-----
V
K
-----
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
N
----------------------------------------------
R
--------
D
N
M
N
Y
--
R
N
L
M
A
D
M
I
A
D
L
Y
D
S
I
K
I
A
K
--
D
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
F
A
-
K
T
-
P
E
Q
N
L
E
A
M
R
N
L
E
-----
Q
L
N
V
----------------
L
G
Y
----------------
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-----------
D
L
P
V
E
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
----------------------
73
PsiBlast_CBE
62.66
36%
-93
- C4 -
-
2Y5S
8
?
B:
[22-290]
--------
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
E
-----
G
-----
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
------
L
N
-----
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
----
R
Q
P
G
A
I
D
A
V
-
R
D
G
N
S
G
L
C
-------
A
M
H
M
L
G
E
P
Q
T
M
Q
V
G
E
P
D
--
Y
G
D
--------
V
V
T
----------------
D
V
R
D
F
--
L
A
A
R
A
Q
A
L
R
------------
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
F
G
K
A
V
-
V
D
D
N
Y
A
L
L
A
A
L
P
DT
A
P
A
R
P
D
G
----------------
R
A
Y
----------------
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
G
G
-----
K
P
P
L
E
-----
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
-
T
V
D
A
L
S
V
W
N
A
V
R
A
A
------------
72
PsiBlast_CBE
59.68
34%
-61
- C4 -
-
1EYE
1
DHPS1_MYCTU
A:
[8-274]
-----------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
A
-----
G
-----
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
Q
-----
G
------
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
------------
W
R
A
V
S
A
D
T
P
H
V
P
VR
Y
G
N
--------
V
V
A
E
------------------------------
V
R
A
D
L
L
A
S
V
A
D
A
V
A
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
F
A
-
K
T
-
A
Q
H
N
W
A
I
L
H
A
L
P
-----
E
L
V
A
----------------
T
G
I
----------------
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
A
G
P
D
G
V
M
R
P
T
D
-----
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
-
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
-----------
81
HHSearch
56.99
36%
13
- C4 -
-
2BMB
1
FOL1_YEAST
A:
[221-544]
-----
T
V
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YLH
E
-----
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
TELPQ
D
K
-----
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
T
-----
R
G
--
D
I
S
T
M
N
R
L
--
A
H
Y
E
--
N
F
A
LGDSIQ
Q
E
F
V
H
N
TDIQQL
D
--------
D
L
K
D
K
---
T
V
L
I
-
R
N
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
A
-
K
T
-
W
K
Q
N
L
Q
I
I
R
H
I
P
-----
I
L
K
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
----------------
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
K
D
V
----------
D
A
K
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
-
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
L
-----------
75
PsiBlast_CBE
54.99
32%
8
- C4 -
-
2BMB
1
FOL1_YEAST
A:
[223-540]
-------
S
P
T
Y
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
-----
A
L
YLHE
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
S
-----
T
E
LPQDK
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
-
P
E
I
C
Y
I
L
S
H
T
R
GDI
S
T
M
N
R
L
A
H
-----
Y
E
N
F
A
--
L
G
D
--------
S
I
Q
Q
------
E
F
V
HNTDIQ
Q
L
D
D
L
K
D
K
T
V
L
I
R
N
V
G
Q
E
I
G
E
R
Y
I
-
K
A
I
D
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
F
A
-
K
T
-
W
K
Q
N
L
Q
I
I
R
H
I
P
-----
I
L
K
N
----------------
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
LRNM
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
K
----------
D
V
D
A
K
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
-
C
S
K
S
I
K
L
A
D
A
I
---------------