@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0638: (2017-12-26 )
MTYLPVALTIAGTDPSGGAGIMADLKSFQARDVYGMAVVTSLVAQNTRGVQLIEHVSPQMLKAQLESIFSDIPPQAVKTGMLATTEIMEIIQPYLKKLDCPYVLDPVMVATSGDALIDSSARDYLKTNLLPLATIITPNLPEAEEIVGFSIHDPEDMQRAGRLILKEFGPQSVVIKGGHLKGGAKDFLFTKNEQFVWESPRIQTCHTHGTGCTFAAVITAELAKGKSLYQAVDKAKAFITKAIQDAPQLGHGSGPVNHTTFKD
Atome Classification :
(29 SA)
.........10........20........30........40....--....--50.......---.60........70........80........90......---.--.-100-.-.......110.-......120........130.......140......--.-150--.......160.......170......----.180-..--.--..-----....190.--..--..-..--.200...--....210.......220.......230.......240.----......--250.......260.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTYL
P
V
A
L
T
I
AGTDPSGG
A
G
I
M
A
D
L
K
SFQARD
V
Y
G
M
A
V
V
T
S
L
V
AQ--NTR
G
--
V
Q
L
I
E
HV
S
P
---
Q
M
L
K
A
Q
L
E
S
I
F
SDI
P
P
Q
A
V
K
TG
M
L
A
T
T
E
I
M
E
I
I
Q
P
Y
L
K
K---L--D-C-P-Y-VLD
P
V
M
V
ATSG-DALI
D
S
S
-
A
R
D
Y
L
K
TNL
L
P
L
A
TIITPNLP
E
A
E
E
I
V
G
--
F
-SIH--
D
P
E
D
M
Q
R
A
G
R
L
I
L
K
EFGP
Q
S
V
V
I
KGG----HL---KG--G--AK-----
D
F
L
F
TK-N--E
Q
--
F
V
-WE--SP
R
I
Q
T
C
--HTHGTG
C
T
F
A
A
V
I
T
A
E
L
AKG
K
S
L
Y
Q
A
V
D
K
A
K
A
F
I
T
K
A
I
----
Q
DAPQL--GHGSGPVNHTTFKD
1
PsiBlast_PDB
83.17
50%
-56
- C1 -
-
4JJP
-
?
A:
[12-248]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
K
G
--
V
F
A
V
E
D
L
N
K
---
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
---
Y
--
N
-
P
-
K
-
Y
L
V
V
D
P
V
M
I
S
K
S
G
-
Y
Y
L
L
K
P
E
-
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
G
--
I
-
K
I
H
--
N
V
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
P
K
F
V
L
M
K
G
G
----
H
L
---
D
G
--
E
--
A
V
-----
D
I
L
V
G
K
-
N
--
I
F
--
K
V
-
Y
K
--
S
E
------------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
I
----
K
---------------------
70
HHSearch
82.25
46%
-34
- C1 -
-
1UB0
6
?
A:
[1-257]
---
M
R
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
T
A
Q
--
N
T
L
G
--
V
Q
R
V
H
L
L
P
P
---
E
V
V
Y
A
Q
I
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
---
F
G-
V
-
R
-
P
-
L
-
V
V
D
P
V
M
----------
A
K
E
-
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
L
L
G
--
R
-
P
I
R
--
T
L
K
E
A
E
E
A
A
K
A
L
L
A
-
L
G
P
K
A
V
L
L
K
G
G
----
H
L
E--
A
------
V
------
D
L
L
A
T
R
-
G
--
G
V
--
L
R
-
F
S
--
A
P
R
V
H
T
R
--
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
----
K
T
A
P
S
L
--
G
H
G
H
G
P
L
D
H
W
----
80
HHSearch
81.31
49%
-49
- C1 -
-
4JJP
-
?
A:
[8-248]
---
K
I
P
T
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
K
G
--
V
F
A
V
E
D
L
N
K
---
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
---
Y
--
N
P
K
-
Y
-
L
-
V
V
D
P
V
M
I
S
K
S
G
-
Y
Y
L
L
K
P
E
-
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
G
--
I
-
K
I
H
--
N
V
D
D
M
K
R
V
G
E
E
I
L
Q
-
L
G
P
K
F
V
L
M
K
G
G
----
H
L
D
G
E
A
-------------
V
D
I
L
V
G
K
N
--
I
F
--
K
V
-
Y
K
--
S
E
------------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
I
----
K
---------------------
79
HHSearch
81.28
49%
-59
- C1 -
-
4JJP
1
?
B:
[9-246]
----
I
P
T
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
K
G
--
V
F
A
V
E
D
L
N
K
---
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
---
Y
--
N
P
K
-
Y
-
L
-
V
V
D
P
V
M
I
------
Y
L
L
K
P
E
-
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
G
--
I
-
K
I
H
--
N
V
D
D
M
K
R
V
G
E
E
I
L
Q
-
L
G
P
K
F
V
L
M
K
G
G
---------
A
-------------
V
D
I
L
V
G
K
N
--
I
F
--
K
V
-
Y
K
--
S
-------------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
---------------------------
5
PsiBlast_PDB
81.21
45%
-50
- C1 -
-
1UB0
6
?
A:
[3-256]
-----
V
A
L
T
I
A
G
S
D
S
G
G
G
A
G
V
Q
A
D
L
K
V
F
F
R
F
G
V
Y
G
T
S
A
L
T
L
V
T
A
Q
--
N
T
L
G
--
V
Q
R
V
H
L
L
P
P
---
E
V
V
Y
A
Q
I
E
S
V
A
Q
D
F
P
L
H
A
A
K
T
G
A
L
G
D
A
A
I
V
E
A
V
A
E
A
V
R
R
---
F
--
G
-
V
R
P
-
L
-
V
V
D
P
V
M
----------
A
K
E
-
A
A
A
A
L
K
E
R
L
F
P
L
A
D
L
V
T
P
N
R
L
E
A
E
A
L
L
G
--
R
-
P
I
R
--
T
-
L
K
E
A
E
E
A
A
K
A
L
L
A
L
G
P
K
A
V
L
L
K
G
G
----
H
L
-------
E
--
A
V
-----
D
L
L
A
T
R
-
G
--
G
V
--
L
R
-
F
S
--
A
P
R
V
H
T
R
--
N
T
H
G
T
G
C
T
L
S
A
A
I
A
A
L
L
A
K
G
R
P
L
A
E
A
V
A
E
A
K
A
Y
L
T
R
A
L
----
K
T
A
P
S
L
--
G
H
G
H
G
P
L
D
H
-----
21
PsiBlast_CBE
81.11
50%
-63
- C1 -
-
4JJP
1
?
B:
[12-246]
-------
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
I
G
T
Y
G
M
S
V
I
T
A
I
T
A
Q
--
N
T
K
G
--
V
F
A
V
E
D
L
N
K
---
K
I
I
K
K
Q
I
E
A
V
F
E
D
I
P
P
R
A
V
K
I
G
M
V
S
S
P
E
I
I
L
E
I
V
E
N
L
K
K
---
Y
--
N
-
P
-
K
-
Y
L
V
V
D
P
V
M
I
------
Y
L
L
K
P
E
-
A
K
E
N
L
I
K
Y
L
I
P
L
A
Y
I
I
T
P
N
I
P
E
A
E
E
I
T
G
--
I
-
K
I
H
--
N
V
D
D
M
K
R
V
G
E
E
I
L
-
Q
L
G
P
K
F
V
L
M
K
G
G
----------------
A
V
-----
D
I
L
V
G
K
-
N
--
I
F
--
K
V
-
Y
K
--
S
-------------
G
C
T
L
S
S
A
I
T
S
Y
L
A
L
G
Y
E
I
T
E
A
V
N
L
S
K
I
Y
I
T
E
A
---------------------------
75
HHSearch
78.64
45%
-54
- C1 -
-
1JXI
1
THID_SALTY
B:
[23-285]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H--
H
--
V
-
R
-
N
-
V
-
V
L
D
T
V
M
L
A
K
S
G
-
D
P
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
-
P
H
A
R-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
------------------------
D
W
L
F
T
R
-
E
--
G
E
--
Q
R
-
F
-----
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
----
A
Q
A
D
T
L
EV
G
K
G
I
G
P
V
H
H
F
H
---
74
HHSearch
76.96
45%
-54
- C1 -
-
1JXH
-
THID_SALTY
A:
[23-285]
-
M
Q
R
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
H
--
H
--
V
-
R
-
N
-
V
-
V
L
D
T
V
M
L
-------
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
-
P
H
A
R-
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
------------------------
D
W
L
F
T
R
-
E
--
G
E
--
Q
R
-
F
-----
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
----
A
Q
A
D
T
L
E
V
G
K
G
I
G
P
V
H
H
F
H
---
22
PsiBlast_CBE
76.73
44%
-58
- C1 -
-
1JXI
1
THID_SALTY
B:
[28-283]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
---
H
--
H
-
V
R
N
-
V
-
V
L
D
T
V
M
L
A
K
S
G
-
D
P
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
P
H
A
R
--
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
------------------------
D
W
L
F
T
R
-
E
--
G
E
--
Q
R
-
F
-----
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
AQ--
A
D
T
L
E
V
--
G
K
G
I
G
P
V
H
H
-----
89
HHSearch
76.55
35%
-54
- C1 -
-
3RM5
-
THI20_YEAST
B:
[20-290]
-
E
K
L
P
T
V
L
S
I
A
G
T
D
P
S
G
G
A
G
I
E
A
D
V
K
T
I
T
A
H
R
C
Y
A
M
T
C
I
T
A
L
N
A
Q
--
T
P
V
K
--
V
Y
S
I
N
N
T
P
K
---
E
V
V
F
Q
T
L
E
S
N
L
K
D
M
K
C
N
V
I
K
T
G
M
L
T
A
A
-
A
I
E
V
L
H
E
K
L
L
Q
L
GE
N
--
R
-
P
-
K
-
L
-
V
V
D
P
V
L
V
A
---------
K
D
-
I
V
S
L
I
T
E
K
V
A
P
F
A
D
I
L
T
P
N
I
P
E
C
Y
K
L
L
G
--
E
-
E
R
K
VN
G
L
Q
D
I
F
Q
I
A
K
D
L
A
K
I
T
K
C
S
N
I
L
V
K
G
G
----
H
I
-----------
T
-----
D
V
L
F
L
G
-
A
EQ
K
F
--
I
I
-
F
K
--
G
N
F
V
N
T
T
--
H
T
H
G
T
G
C
T
L
A
S
A
I
A
S
N
L
A
R
G
Y
S
L
P
Q
S
V
Y
G
G
I
E
Y
V
Q
N
A
V
----
A
I
G
C
------------------
3
PsiBlast_PDB
76.31
44%
-56
- C1 -
-
1JXI
1
THID_SALTY
A:
[28-283]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
---
H
--
H
-
V
R
N
-
V
-
V
L
D
T
V
M
L
A
K
S
G
-
D
P
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
P
H
A
R
--
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
------------------------
D
W
L
F
T
R
-
E
--
G
E
--
Q
R
-
F
-----
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
--
A
D
T
L
E
V
--
G
K
G
I
G
P
V
H
H
-----
60
Fugue
75.88
42%
-62
- C1 -
-
1JXH
-
THID_SALTY
A:
[23-288]
M
Q
R
-
I
N
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
---
H
--
H
-
V
-
R
N
V
-
V
L
D
T
V
M
L
-------
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
-
P
H
A
--
R
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
M
G
C
E
A
V
L
M
K
G
D
----
W
L
---
F
T
--
R
--
E
G
----------------------
E
Q
--
R
F
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
----
A
Q
A
D
T
L
E
V
G
K
G
I
G
P
V
H
H
F
H
A
W
W
2
PsiBlast_PDB
75.16
44%
-57
- C1 -
-
1JXH
-
THID_SALTY
A:
[28-283]
------
A
L
T
I
A
G
T
D
P
S
G
G
A
G
I
Q
A
D
L
K
T
F
S
A
L
G
A
Y
G
C
S
V
I
T
A
L
V
A
E
--
N
T
C
G
--
V
Q
S
V
Y
R
I
E
P
---
D
F
V
A
A
Q
L
D
S
V
F
S
D
V
R
I
D
T
T
K
I
G
M
L
A
E
T
D
I
V
E
A
V
A
E
R
L
Q
R
---
H
--
H
-
V
R
N
-
V
-
V
L
D
T
V
M
L
-------
L
L
S
P
S
-
A
I
E
T
L
R
V
R
L
L
P
Q
V
S
L
I
T
P
N
L
P
E
A
A
A
L
L
D
--
A
P
H
A
R
--
T
E
Q
E
M
L
A
Q
G
R
A
L
L
A
-
M
G
C
E
A
V
L
M
K
G
------------------------
D
W
L
F
T
R
-
E
--
G
E
--
Q
R
-
F
-----
R
V
N
T
K
--
N
T
H
G
T
G
C
T
L
S
A
A
L
A
A
L
R
P
R
H
R
S
W
G
E
T
V
N
E
A
K
A
W
L
S
A
A
L
A
Q
--
A
D
T
L
E
V
--
G
K
G
I
G
P
V
H
H
-----
13
PsiBlast_PDB
74.77
34%
-38
- C1 -
-
3RM5
-
THI20_YEAST
A:
[22-305]
---
L
P
T
V
L
S
I
A
G
T
D
P
S
G
G
A
G
I
E
A
D
V
K
T
I
T
A
H
R
C
Y
A
M
T
C
I
T
A
L
N
A
Q
--
T
P
V
K
--
V
Y
S
I
N
N
T
P
K
---
E
V
V
F
Q
T
L
E
S
N
L
K
D
M
K
C
N
V
I
K
T
G
M
L
-
T
A
A
A
I
E
V
L
H
E
K
L
L
Q
---
L
GE
N
-
R
-
P
K
L
-
V
V
D
P
V
L
----------
G
K
D
-
I
V
S
L
I
T
E
K
V
A
P
F
A
D
I
L
T
P
N
I
P
E
C
Y
K
L
L
G
E
E
R
-
K
V
N
--
G
L
Q
D
I
F
Q
I
A
K
D
L
A
K
I
T
K
C
S
N
I
L
V
K
G
G
----
H
-------------E
K
Y
I
T
D
V
L
F
L
G
-
A
--
E
Q
K
F
I
I
-
F
K
--
G
N
F
V
N
T
T
--
H
T
H
G
T
G
C
T
L
A
S
A
I
A
S
N
L
A
R
G
Y
S
L
P
Q
S
V
Y
G
G
I
E
Y
V
Q
N
A
V
A
I
GC
D
V
T
K
E
T
--
V
K
D
N
G
P
I
N
H
-----
25
PsiBlast_CBE
73.20
41%
-3
- C1 -
-
2I5B
1
PDXK_BACSU
D:
[6-266]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
DP
N
N
S
W
--
N
H
Q
V
F
P
I
D
T
---
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
---
K
--
Q
-
L
-
K
N
V
-
V
I
D
P
V
M
V
C
K
G
A
-
N
E
V
L
Y
P
E
-
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
--
M
D
E
L
K
--
T
V
D
D
M
I
E
A
A
K
K
I
-
H
A
L
G
A
Q
Y
V
V
I
T
G
G
GKLK
H
E
---
K
------
A
V
-----
D
V
L
Y
D
G
-
E
--
T
A
--
E
V
-
L
E
--
S
E
M
I
D
T
P
--
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
----
K
E
S
F
P
L
--
N
Q
Y
V
G
P
T
K
H
S
A
L
R
-
73
HHSearch
73.02
34%
-51
- C1 -
-
4YWR
1
?
A:
[10-246]
---
R
P
T
V
L
C
F
S
G
L
D
P
S
G
G
A
G
L
Q
A
D
I
E
A
I
G
Q
S
G
A
H
A
A
I
A
C
T
A
L
T
I
Q
--
N
S
Q
Q
--
V
F
G
F
E
A
T
S
K
---
E
L
L
L
A
Q
A
N
A
V
V
G
D
L
P
I
K
C
V
K
S
G
M
L
G
T
T
D
N
I
A
A
L
A
E
F
L
R
A
H
--
P
--
D
-
Y
-
Q
-
Y
-
V
L
D
P
V
L
V
A
N
S
G
-
G
S
L
G
D
Q
A
T
L
V
K
A
F
-
V
E
L
I
P
L
A
T
L
I
T
P
N
T
V
E
L
R
A
L
T
G
--
V
-
T
-------
D
L
D
Q
A
T
Q
K
L
F
E
-
M
G
A
K
A
V
L
V
K
G
G
----
H
E
---
D
T
PD
F
--
I
K
-----
N
S
L
Y
I
D
-
G
E-
L
A
--
A
S
-
S
T
--
C
P
R
------------
C
S
L
A
S
F
I
A
G
R
L
A
L
G
D
S
L
K
I
A
V
Q
H
A
E
T
W
L
F
G
V
L
--------------------------
12
PsiBlast_PDB
72.71
34%
-74
- C1 -
-
4YWR
1
?
A:
[11-246]
----
P
T
V
L
C
F
S
G
L
D
P
S
G
G
A
G
L
Q
A
D
I
E
A
I
G
Q
S
G
A
H
A
A
I
A
C
T
A
L
T
I
Q
--
N
S
Q
Q
--
V
F
G
F
E
A
T
S
K
---
E
L
L
L
A
Q
A
N
A
V
V
G
D
L
P
I
K
C
V
K
S
G
M
L
G
T
T
D
N
I
A
A
L
A
E
F
L
R
A
---
H
P-
D
-
Y
-
Q
-
Y
-
V
L
D
P
V
L
V
A
N
S
G
-
G
S
L
G
D
Q
A
-
T
L
V
K
A
F
V
E
L
I
P
L
A
T
L
I
T
P
N
T
V
E
L
R
A
L
T
G
--
V
-
T
-------
D
L
D
Q
A
T
Q
K
L
F
-
E
M
G
A
K
A
V
L
V
K
G
G
----
H
E
---
D
------
T
P
-----
D
F
I
--
K
-
N
--
S
L
--
Y
I
D
G
E
--
L
A
A
S
S
T
C
P
R------
C
S
L
A
S
F
I
A
G
R
L
A
L
G
D
S
L
K
I
A
V
Q
H
A
E
T
W
L
F
G
V
L
--------------------------
4
PsiBlast_PDB
72.68
41%
-2
- C1 -
-
2I5B
1
PDXK_BACSU
A:
[6-266]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
W
--
N
H
Q
V
F
P
I
D
T
---
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
---
K
--
Q
-
L
-
K
N
V
-
V
I
D
P
V
M
V
C
K
G
A
-
N
E
V
L
Y
P
E
-
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
--
M
D
E
L
K
--
T
V
D
D
M
I
E
A
A
K
K
I
-
H
A
L
G
A
Q
Y
V
V
I
T
G
G
GKLK
H
E
---
K
------
A
V
-----
D
V
L
Y
D
G
-
E
--
T
A
--
E
V
-
L
E
--
S
E
M
I
D
T
P
--
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
----
K
E
S
F
P
L
--
N
Q
Y
V
G
P
T
K
H
S
A
L
R
-
86
HHSearch
72.42
42%
4
- C1 -
-
2I5B
1
PDXK_BACSU
A:
[3-262]
---
M
H
K
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
--
D
P
N
N
SW
N
H
Q
V
F
P
I
D
T
---
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
---
K
--
Q
L
K
-
N
-
V
-
V
I
D
P
V
M
V
C
K
G
A
N
E
V
L
Y
P
-
E
-
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
--
M
-
D
E
L
K-
T
V
D
D
M
I
E
A
A
K
K
I
H
A
-
L
G
A
Q
Y
V
V
I
T
G
G
----
G
K
---
L
K
--
H
EK
A
V
-----
D
V
L
Y
D
G
-
E
--
T
A
--
E
V
-
L
E
--
S
E
M
I
D
T
P
--
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
----
K
E
S
F
P
L
--
N
Q
Y
V
G
P
T
K
H
-----
7
PsiBlast_PDB
72.16
38%
-7
- C1 -
-
4C5K
1
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
C
K
---
D
E
V
L
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
Q
Q
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
26
PsiBlast_CBE
72.11
41%
-1
- C1 -
-
2I5B
1
PDXK_BACSU
C:
[6-266]
------
A
L
T
I
A
G
S
D
S
S
G
G
A
G
I
Q
A
D
L
K
T
F
Q
E
K
N
V
Y
G
M
T
A
L
T
V
I
V
A
M
D
P
N
N
S
W
--
N
H
Q
V
F
P
I
D
T
---
D
T
I
R
A
Q
L
A
T
I
T
D
G
I
G
V
D
A
M
K
T
G
M
L
P
T
V
D
I
I
E
L
A
A
K
T
I
K
E
---
K
--
Q
-
L
-
K
N
V
-
V
I
D
P
V
M
V
C
K
G
A
-
N
E
V
L
Y
P
E
-
H
A
Q
A
L
R
E
Q
L
A
P
L
A
T
V
I
T
P
N
L
F
E
A
S
Q
L
S
G
--
M
D
E
L
K
--
T
V
D
D
M
I
E
A
A
K
K
I
-
H
A
L
G
A
Q
Y
V
V
I
T
G
G
GKLK
H
E
---
K
------
A
V
-----
D
V
L
Y
D
G
-
E
--
T
A
--
E
V
-
L
E
--
S
E
M
I
D
T
P
--
Y
T
H
G
A
G
C
T
F
S
A
A
V
T
A
E
L
A
K
G
A
E
V
K
E
A
I
Y
A
A
K
E
F
I
T
A
A
I
----
K
E
S
F
P
L
--
N
Q
Y
V
G
P
T
K
H
S
A
L
R
-
35
PsiBlast_CBE
71.68
38%
-3
- C1 -
-
4C5L
1
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
C
K
G
------
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
Q
----
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
30
PsiBlast_CBE
71.34
38%
-5
- C1 -
-
4C5N
2
?
B:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
--------
L
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
Q
Q
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
11
PsiBlast_PDB
70.56
34%
-69
- C1 -
-
4YL5
2
?
A:
[11-245]
----
P
T
V
L
C
F
S
G
L
D
P
S
G
G
A
G
L
Q
A
D
I
E
A
I
G
Q
S
G
A
H
A
A
I
A
C
T
A
L
T
I
Q
--
N
S
Q
Q
--
V
F
G
F
E
A
T
S
K
---
E
L
L
L
A
Q
A
N
A
V
V
G
D
L
P
I
K
C
V
K
S
G
M
L
G
T
T
D
N
I
A
A
L
A
E
F
L
R
A
---
H
P-
D
-
Y
-
Q
-
Y
-
V
L
D
P
V
L
V
A
N
S
G
-
G
S
L
G
D
Q
A
-
T
L
V
K
A
F
V
E
L
I
P
L
A
T
L
I
T
P
N
T
V
E
L
R
A
L
T
G
--
V
-
T
-------
D
L
D
Q
A
T
Q
K
L
F
-
E
M
G
A
K
A
V
L
V
K
G
G
----
H
E
---
D
------
T
P
-----
D
F
I
--
K
-
N
--
S
L
--
Y
I
D
G
E
--
L
A
A
S
S
T
C
P-------
C
S
L
A
S
F
I
A
G
R
L
A
L
G
D
S
L
K
I
A
V
Q
H
A
E
T
W
L
F
G
V
---------------------------
34
PsiBlast_CBE
70.48
38%
-5
- C1 -
-
4C5L
1
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
LPM
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
C
K
G
------
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
LT
T
D
M
F
Q
----
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
28
PsiBlast_CBE
69.85
38%
-7
- C1 -
-
4C5N
2
?
D:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
LPM
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
C
--------
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
LT
T
D
M
F
Q
Q
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
8
PsiBlast_PDB
69.46
38%
-7
- C1 -
-
4C5L
1
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
V
C
K
G
E
-----
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
-----------------
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
--
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
10
PsiBlast_PDB
68.36
38%
-2
- C1 -
-
4C5N
2
?
A:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
---------
L
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
Q
Q
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-
29
PsiBlast_CBE
67.94
38%
2
- C1 -
-
4C5N
2
?
C:
[3-264]
---
L
K
K
V
L
T
I
A
G
S
D
T
S
A
G
A
G
M
Q
A
D
L
K
T
F
Q
E
L
D
T
Y
G
M
V
A
L
T
A
I
V
T
M
--
D
K
D
----
T
W
S
H
D
V
T
P
L
P
M
D
V
F
E
K
Q
L
E
T
A
L
S
-
I
G
P
D
A
I
K
T
G
M
L
G
T
E
E
I
I
K
R
A
G
E
V
Y
E
A
---
S
--
N
-
A
-
Q
-
Y
F
V
V
D
P
V
M
----------
N
P
G
-
N
T
E
A
M
I
K
Y
L
L
P
K
A
T
V
V
T
P
N
L
F
E
A
G
Q
L
S
G
--
L
G
K
L
N
--
S
I
E
D
M
K
K
A
A
T
I
I
F
D
K
-
G
A
Q
H
V
I
I
K
G
G
----
K
A
---
L
D
--
Q
--
D
K
-----
S
Y
D
L
Y
Y
-
D
--
G
Q
--
T
F
-
Y
Q
L
T
T
D
M
F
Q
Q
S
--
Y
N
H
G
A
G
C
T
F
A
A
A
T
T
A
Y
L
A
N
G
K
S
P
K
E
A
V
I
S
A
K
A
F
V
A
S
A
I
----
K
N
G
W
K
M
--
N
D
F
V
G
P
V
D
H
G
A
Y
N
-