@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : spr0783: (2017-12-29 )
MIYFDNSATTKPYPEALETYMQVASKILGNPSSLHRLGDQATRILDASRQQIADLIGKKSDEIFFTSGGTEGDNWLIKGVAFEKAQFGKHIIVSAIEHPAVKESALWLKSQGFEVDFAPVDKKGLVDVEALAGLIRHDTILVSIMAVNNEIGSIQPIEAISEFLADKPTISFHVDAVQALAKIPTEKYLTERVDCATFSSHKFHGVRGVGFVYIKSGKKITPLLTGGGQERDYRSTTENVAGIAATAKALRLSMEKLDIFRSKTGQMKAVIRQALLNYPDIFVFSDEENFAPHILTFGIKGVRGEVIVHAFEDYDIFISTTSACSSKAGKPAGTLIAMGVDKDKAKSAVRLSLDLENDMSQVEQFLTKLKLIYNQTRKVR
Atome Classification :
(29 SA)
-.........10.....-...20.....--...30-...-.....40........50........60........70........80-.--...-.---..--..-----90--.........100......-.110........120-.......130....--...140.......150.......160..---------..--.-..170-.......180--.......190..--......200.......210..--....--.-------220.---......230.......240.......250.......260.....-..270-.....---------..--..280...--...-.290.......300-........310.......320..-.....330.......340.......350.---......360.......370.......380
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
-
M
I
YFDNSATTKP
Y
P
E
A
-
L
E
T
Y
M
Q
V
A
S
K
--ILG
N
P
-
S
S
L
-
H
R
L
G
D
Q
A
T
R
I
L
D
A
S
R
Q
Q
I
A
D
L
IGKKSD
E
I
F
F
TSGGTEGD
N
W
L
I
KG
V
--
A
--F
E
K
-
A
---QF--G
K
-----
H
---
I
I
V
S
AIEHPAVK
E
S
A
L
W
L
-KSQ-GF
E
V
D
FAPVDK-KGLV
D
V
E
A
L
A
G
L
I
R--H
D
T
I
L
V
S
I
M
A
VNNEIGSIQ
P
I
E
A
I
S
E
F
L---------AD--K-P
T
I
S
F
-
H
V
D
A
V
Q
A
L
A
K--IP
T
E
K
Y
L
T
E
-RV--DCATFSSHKFHG
V
R
G
V
G
F
V
Y
I--KSG
K
--
K
-------
I
T
P
L
---LTGGGQERDYRS
T
T
E
N
V
A
G
I
A
A
T
A
K
A
L
R
L
S
M
E
K
L
D
I
F
R
SKT
G
Q
M
-
K
A
V
---
I
R
Q
A
L
---------LN--YP
D
I
F
V
FS--DEE-NFA
P
H
I
L
T
F
GIKG--VRG
E
V
I
V
H
A
FED
Y
D
I
F
I
STTSAC-SSKAGKPA
G
T
L
I
A
MGV
D
K
D
KAK
S
A
V
R
L
S
L
---DL
E
N
D
M
S
Q
V
E
Q
F
L
T
K
L
K
L
I
Y
NQTRKVR--
35
HHSearch
90.42
35%
-91
- C1 -
-
4HVK
11
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
-
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
-----
K
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
-
D
V
E
K
I
-
G
A
--
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
36
HHSearch
89.19
35%
-84
* C1 *
-
4EB5
6
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
S
A
K
P
V
D
E
R
I
-
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
-----
K
A
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
-
D
V
E
K
I
-
G
A
--
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
38
HHSearch
86.34
39%
-36
- C1 -
-
1EG5
2
?
A:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
--
E
T
F
-
E
---
K
R
--
K
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
K
N
K
--
E
T
L
V
-
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
-
S
L
E
K
L
-
E
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
-
G
A
H
I
I
T
--
P
L
E
-
I
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
37
HHSearch
84.70
39%
-33
- C1 -
-
1ECX
2
?
B:
[2-376]
-
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
--
E
T
F
-
E
---
K
R
--
K
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
KN
K
--
E
T
L
V
-
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
-
S
L
E
K
L
-
E
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
-
G
A
H
I
I
T
--
P
L
E
-
I
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
2
PsiBlast_PDB
79.50
39%
-18
- C1 -
-
1EG5
2
?
A:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
F
E
K
-
R
---
K
----
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
--
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
-
G
A
H
I
I
T
--
P
L
E
-
I
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
----------
21
PsiBlast_CBE
79.29
40%
-19
- C1 -
-
1ECX
2
?
B:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
ET
F
E
K
-
R
---
K
----
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
--
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
-
G
A
H
I
I
T
--
P
L
E
-
I
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
------------
R
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
----------
1
PsiBlast_PDB
78.88
40%
-20
- C1 -
-
1ECX
2
?
A:
[3-372]
--
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
E
T
F
E
K
-
R
---
K
----
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
--
K
-
N
K
E
T
L
V
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
L
E
K
L
E
--
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
-
G
A
H
I
I
T
--
P
L
E
-
I
S
L
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
----------
10
PsiBlast_PDB
78.57
34%
0
- C- -
-
5KZ5
-
NFS1_HUMAN
1:
[5--47]
--------------
P
R
V
-
L
D
A
M
L
P
Y
L
I
N
--
Y
Y
G
N
P
H
S
R
T
-
H
A
Y
G
W
E
S
E
A
A
M
E
R
A
R
Q
Q
V
A
S
L
I
G
A
D
P
R
E
I
I
F
T
S
G
A
T
E
S
N
N
I
A
I
K
G
V
--
A
--
R
F
Y
-
R
---
S
R
--
K
K
-----
H
---
L
I
T
T
Q
T
E
H
K
C
V
L
D
S
C
R
S
L
-
E
A
E
-
G
F
Q
V
T
Y
L
P
V
Q
K
-
S
G
I
I
D
L
K
E
L
E
A
A
I
Q
--
P
D
T
S
L
V
S
V
M
T
V
N
N
E
I
G
V
K
Q
P
I
A
E
I
G
R
I
C
---------
S
S
--
R
--
K
V
Y
F
-
H
T
D
A
A
Q
A
V
G
K
--
I
P
L
D
-
V
N
D
M
-
K
I
--
D
L
M
S
I
S
G
H
K
I
Y
G
P
K
G
V
G
A
I
Y
I
--
R
R
R
P
RV
R
-------
V
E
A
L
---
Q
S
G
G
G
Q
E
R
G
M
R
S
G
T
V
P
T
P
L
V
V
G
L
G
A
A
C
E
V
A
Q
Q
E
M
E
Y
D
H
K
R
I
S
K
L
S
E
R
L
---
I
Q
N
I
M
---------
K
S
--
L
P
D
V
V
M
N
G
--
D
P
K
-
H
H
Y
P
G
C
I
N
L
S
F
A
Y
--
V
E
G
E
S
L
L
M
A
L
K
--
D
V
A
L
S
S
G
S
A
C
-
T
S
A
S
L
E
P
S
Y
V
L
R
A
I
G
T
D
E
D
L
A
H
S
S
I
R
F
G
I
--------------------------------
60
Fugue
76.38
39%
14
- C1 -
-
1ECX
2
?
A:
[1-376]
M
R
V
Y
F
D
N
N
A
T
T
R
V
D
D
R
V
-
L
E
E
M
I
V
F
Y
R
E
--
K
Y
G
N
P
-
N
S
A
-
H
G
M
G
I
E
A
N
L
H
M
E
K
A
R
E
K
V
A
K
V
L
G
V
S
P
S
E
I
F
F
T
S
C
A
T
E
S
I
N
W
I
L
K
T
V
--
A
--
E
T
F
-
E
---
K
R
--
K
R
-----
T
---
I
I
T
T
P
I
E
H
K
A
V
L
E
T
M
K
Y
L
-
S
M
K
-
G
F
K
V
K
Y
V
P
V
D
S
-
R
G
V
V
K
L
E
E
L
E
K
L
V
D
--
E
D
T
F
L
V
S
I
M
A
A
N
N
E
V
G
T
I
Q
P
V
E
D
V
T
R
I
V
---------
K
K
--
K
N
K
E
T
L
V
-
H
V
D
A
V
Q
T
I
G
K
--
I
P
F
S
-
L
E
K
L
-
E
V
--
D
Y
A
S
F
S
A
H
K
F
H
G
P
K
G
V
G
I
T
Y
I
--
R
K
G
V
--
P
-------
I
R
P
L
---
I
H
G
G
G
Q
E
R
G
L
R
S
G
T
Q
N
V
P
G
I
V
G
A
A
R
A
M
E
I
A
V
E
E
L
S
E
A
A
K
H
M
E
K
L
-
R
S
K
---
L
V
S
G
L
---------
M
N
--
L
G
A
H
I
I
T
P
--
L
E
I
-
S
L
-
P
N
T
L
S
V
S
F
P
N
--
I
R
G
S
T
L
Q
N
L
L
S
G
Y
G
I
Y
V
S
T
-------------
H
V
L
D
A
M
G
V
D
R
R
I
A
Q
G
A
I
R
I
S
L
---
C
K
Y
N
T
E
E
E
V
D
Y
F
L
K
K
I
E
E
I
L
S
F
L
------
7
PsiBlast_PDB
76.05
35%
-4
- C1 -
-
4EB7
7
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
-
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
6
PsiBlast_PDB
75.60
35%
-3
- C1 -
-
4EB5
6
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
40
HHSearch
74.84
32%
3
- C1 -
-
4ISY
2
ISCSL_MYCTU
C:
[13-394]
--
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
-
I
E
A
M
A
A
V
Q
R
T
---
I
G
N
A
-
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
--
W
A
R
-
R
DAE
P
H
--
R
R
-----
R
---
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
V
E
H
E
-
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
SH
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
E
--
F
--
G
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
--
L
P
L
-
D
F
G
A
S
-
G
L
--
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
R
D
V
--
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
-
R
D
R
---
L
V
E
G
V
---------
L
A
E-
I
D
D
V
C
L
N
G
--
A
D
D
P
M
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
G
S
A
--------
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
---
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
----
24
PsiBlast_CBE
74.52
35%
1
- C1 -
-
4EB5
5
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
8
PsiBlast_PDB
74.22
35%
3
- C1 -
-
4HVK
11
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
61
Fugue
74.20
32%
-0
- C1 -
-
4ISY
3
ISCSL_MYCTU
A:
[12-398]
-
S
A
Y
L
D
H
A
A
T
T
P
M
H
P
A
A
-
I
E
A
M
A
A
V
Q
R
T
--
I
-
G
N
A
-
S
S
L
-
H
T
S
G
R
S
A
R
R
R
I
E
E
A
R
E
L
I
A
D
K
L
G
A
R
P
S
E
V
I
F
T
A
G
G
T
E
S
D
N
L
A
V
K
G
I
--
Y
--
W
A
R
-
R
---
D
A
--
E
P
-----
H
RR
R
I
V
T
T
E
V
E
H
H
A
V
L
D
S
V
N
W
L
-
V
E
H
E
G
A
H
V
T
W
L
P
T
A
A
-
D
G
S
V
S
A
T
A
L
R
E
A
L
Q
S
H
D
D
V
A
L
V
S
V
M
W
A
N
N
E
V
G
T
I
L
P
I
A
E
M
S
V
V
A
---------
M
E
--
F
-
G
-
V
P
M
-
H
S
D
A
I
Q
A
V
G
Q
--
L
P
L
D
-
F
G
A
S
-
G
L
--
S
A
M
S
V
A
G
H
K
F
G
G
P
P
G
V
G
A
L
L
L
--
R
R
D
V
--
T
-------
C
V
P
L
---
M
H
G
G
G
Q
E
R
D
I
R
S
G
T
P
D
V
A
S
A
V
G
M
A
T
A
A
Q
I
A
V
D
G
L
E
E
N
S
A
R
L
R
L
L
-
R
D
R
---
L
V
E
G
V
---------
L
A
--
E
I
D
D
V
C
L
N
GA
D
D
P
-
M
R
L
A
G
N
A
H
F
T
F
R
G
--
C
E
G
D
A
L
L
M
L
L
D
A
N
G
I
E
C
S
T
---------
G
S
P
S
H
V
L
I
A
M
G
V
D
A
A
S
A
R
G
S
L
R
L
S
L
---
G
H
T
S
V
E
A
D
V
D
A
A
L
E
V
L
P
G
A
V
A
R
A
R
R
A
A
LA
23
PsiBlast_CBE
73.70
35%
0
- C1 -
-
4EB7
4
ISCS2_ARCFU
B:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
D
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
S
A
C
-
S
S
K
T
L
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
5
PsiBlast_PDB
73.53
35%
3
- C1 -
-
4R5F
10
ISCS2_ARCFU
A:
[2-376]
--
A
Y
F
D
Y
T
-
S
A
K
P
V
D
E
R
I
L
E
A
M
L
P
Y
M
T
E
--
S
F
G
N
P
-
S
S
V
-
H
S
Y
G
F
K
A
R
E
A
V
Q
E
A
R
E
K
V
A
K
L
V
N
G
G
G
G
T
V
V
F
T
S
G
A
T
E
A
N
N
L
A
I
I
G
Y
--
A
--
M
R
N
-
A
---
R
K
--
G
K
-----
H
---
I
L
V
S
A
V
E
H
M
S
V
I
N
P
A
K
F
L
-
Q
K
Q
-
G
F
E
V
E
Y
I
P
V
G
K
-
Y
G
E
V
D
V
S
F
I
D
Q
K
L
R
--
D
D
T
I
L
V
S
V
Q
H
A
N
N
E
I
G
T
I
Q
P
V
E
E
I
S
E
V
L
---------
A
G
--
K
-
A
--
A
L
-
H
I
D
A
T
A
S
V
G
Q
--
I
E
V
D
---
V
E
-
K
I
GA
D
M
L
T
I
S
S
N
K
I
Y
G
P
K
G
V
G
A
L
W
I
--
R
K
E
A
--
K
-------
L
Q
P
V
---
I
L
G
G
G
Q
E
N
G
L
R
S
G
S
E
N
V
P
S
I
V
G
F
G
K
A
A
E
I
T
A
M
E
W
R
E
E
A
E
R
L
R
R
L
-
R
D
R
---
I
I
D
N
V
---------
L
K
--
I
E
E
S
Y
L
N
G
--
H
P
E
-
K
R
L
P
N
N
V
N
V
R
F
S
Y
--
I
E
G
E
S
I
V
L
S
L
D
M
A
G
I
Q
A
S
T
G
---------
Q
P
S
H
V
L
M
A
C
G
L
K
H
E
E
A
H
G
T
L
L
L
T
L
---
G
R
Y
N
T
D
E
D
V
D
R
L
L
E
V
L
P
G
V
I
E
R
L
R
S
M
---
25
PsiBlast_CBE
68.46
33%
-75
- C1 -
-
5USR
1
?
C:
[28-379]
--
L
Y
M
D
V
Q
A
T
T
P
L
D
P
R
V
-
L
D
A
M
L
P
Y
L
I
N
--
Y
Y
G
----------
G
W
E
S
E
A
A
M
E
R
A
R
Q
Q
V
A
S
L
I
G
A
D
P
R
E
I
I
F
T
S
G
A
T
E
S
N
N
I
A
I
K
G
V
--
A
--
R
F
Y
-
R
---
S
R
--
K
K
-----
H
---
L
I
T
T
Q
T
E
H
K
C
V
L
D
S
C
R
S
L
-
E
A
E
-
G
F
Q
V
T
Y
L
P
V
Q
K
-
S
G
I
I
D
L
K
E
L
E
A
A
I
Q
--
P
D
T
S
L
V
S
V
M
T
V
N
N
E
I
G
V
K
Q
P
I
A
E
I
G
R
I
C
---------
S
S
--
R
--
K
V
Y
F
-
H
T
D
A
A
Q
A
V
G
K
--
I
P
L
D
V
N
-
D
M
-
K
I
--
D
L
M
S
I
S
G
H
K
I
Y
G
P
K
G
V
G
A
I
Y
I
--
R
R
R
P
R
V
R
-------
V
E
A
L
---
Q
------------
T
V
P
T
P
L
V
V
G
L
G
A
A
C
E
V
A
Q
Q
E
M
E
Y
D
H
K
R
I
S
K
L
S
E
R
L
---
I
Q
N
I
M
---------
K
S
--
L
P
D
V
V
M
N
G
--
D
P
K
-
H
H
Y
P
G
C
I
N
L
S
F
A
Y
--
V
E
G
E
S
L
L
M
A
L
K
--
D
-----------------
S
Y
V
L
R
A
I
G
T
D
E
D
L
A
H
S
S
I
R
F
G
I
--------------------------------
14
PsiBlast_PDB
68.10
31%
-8
- C1 -
-
3A9Z
3
SCLY_RAT
A:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
-
I
Q
A
V
T
E
A
M
K
E
--
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
--
F
H
E
-
Q
---
Q
T
L
Q--T
R
P
--
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
--
L
-
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
---
L
E
E
R
L
E
A
E
FGKRIH
L
N
SR
F
P
G
V
E
R
L
----------
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
---
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
32
PsiBlast_CBE
67.23
31%
-7
- C1 -
-
3A9X
2
SCLY_RAT
B:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
-
I
Q
A
V
T
E
A
M
K
E
--
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
--
F
H
E
-
Q
---
Q
T
L
Q--T
R
P
--
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
--
L
-
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
---
L
E
E
R
L
E
A
E
FGKRIH
L
N
SR
F
P
G
V
E
R
L
----------
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
---
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
30
PsiBlast_CBE
66.24
31%
11
- C1 -
-
3A9Z
3
SCLY_RAT
B:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
-
I
Q
A
V
T
E
A
M
K
E
--
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
--
F
H
E
-
Q
---------T
R
P
--
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
--
L
-
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
---
L
E
E
R
L
E
A
E
FGKRIH
L
N
SR
F
P
G
V
E
R
L
----------
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
---
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
4
PsiBlast_PDB
65.16
38%
20
- C1 -
-
3LVK
1
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
-
A
E
K
M
M
Q
F
M
T
M
DG
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
--
N
F
Y
-
Q
---
K
K
--
G
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
--
R
-
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
P
R
V
--
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
-
R
N
R
---
L
W
N
G
I
---------
K
D
--
I
E
E
V
Y
L
N
G
--
D
L
E
-
H
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
--------------------------------
31
PsiBlast_CBE
64.76
31%
12
- C1 -
-
3A9Y
4
SCLY_RAT
B:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
-
I
Q
A
V
T
E
A
M
K
E
--
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
--
F
H
E
-
Q
---
Q
-----T
R
P
--
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
--
L
-
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
---
L
E
E
R
L
E
A
E
FGKRIH
L
N
SR
F
P
G
V
E
R
L
----------
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
S
C
H
S
D
H
E
D
R
P
S
P
V
L
L
S
C
G
I
P
V
D
V
A
R
N
A
V
R
L
S
V
---
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
22
PsiBlast_CBE
64.20
38%
21
- C1 -
-
3LVJ
2
ISCS_ECO57
B:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
-
A
E
K
M
M
Q
F
M
T
M
DG
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
--
N
F
Y
-
Q
---
K
K
--
G
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
--
R
-
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
RR
K
P
R
V
--
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
-
R
N
R
---
L
W
N
G
I
---------
K
D
--
I
E
E
V
Y
L
N
G
--
D
L
E
-
H
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
S
A
C
-----
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
--------------------------------
3
PsiBlast_PDB
64.07
38%
20
- C1 -
-
3LVJ
2
ISCS_ECO57
A:
[24-376]
--
I
Y
L
D
Y
S
A
T
T
P
V
D
P
R
V
-
A
E
K
M
M
Q
F
M
T
M
DG
T
F
G
N
P
-
A
S
R
S
H
R
F
G
W
Q
A
E
E
A
V
D
I
A
R
N
Q
I
A
D
L
V
G
A
D
P
R
E
I
V
F
T
S
G
A
T
E
S
D
N
L
A
I
K
G
A
--
A
--
N
F
Y
-
Q
---
K
K
--
G
K
-----
H
---
I
I
T
S
K
T
E
H
K
A
V
L
D
T
C
R
Q
L
-
E
R
E
-
G
F
E
V
T
Y
L
A
P
Q
R
-
N
G
I
I
D
L
K
E
L
E
A
A
M
R
--
D
D
T
I
L
V
S
I
M
H
V
N
N
E
I
G
V
V
Q
D
I
A
A
I
G
E
M
C
---------
R
A
--
R
-
G
I
I
-
Y
-
H
V
D
A
T
Q
S
V
G
K
--
L
P
I
D
--
L
S
Q
L
K
V
--
D
L
M
S
F
S
G
H
K
I
Y
G
P
K
G
I
G
A
L
Y
V
R
R
K
P
R
V
--
R
-------
I
E
A
Q
---
M
H
G
G
G
H
E
R
G
M
R
S
G
T
L
P
V
H
Q
I
V
G
M
G
E
A
Y
R
I
A
K
E
E
M
A
T
E
M
E
R
L
R
G
L
-
R
N
R
---
L
W
N
G
I
---------
K
D
--
I
E
E
V
Y
L
N
G
--
D
L
E
-
H
G
A
P
N
I
L
N
V
S
F
N
Y
--
V
E
G
E
S
L
I
M
A
L
K
--
D
L
A
V
S
S
G
-------
S
L
E
P
S
Y
V
L
R
A
L
G
L
N
D
E
L
A
H
S
S
I
R
F
S
L
--------------------------------
13
PsiBlast_PDB
63.77
31%
4
- C1 -
-
3A9X
2
SCLY_RAT
A:
[20-427]
--
V
Y
M
D
Y
N
A
T
T
P
L
E
P
E
V
-
I
Q
A
V
T
E
A
M
K
E
--
A
W
G
N
P
-
S
S
S
-
Y
V
A
G
R
K
A
K
D
I
I
N
T
A
R
A
S
L
A
K
M
I
G
G
K
P
Q
D
I
I
F
T
S
G
G
T
E
S
N
N
L
V
I
H
S
T
V
R
C
--
F
H
E
-
Q
---
Q
T
L
Q
G
-EG
T
R
P
H
---
F
I
T
C
T
V
E
H
D
S
I
R
L
P
L
E
H
L
V
E
D
Q
-
V
A
E
V
T
F
V
P
V
S
K
V
N
G
Q
V
E
V
E
D
I
L
A
A
V
R
--
P
T
T
C
L
V
T
I
M
L
A
N
N
E
T
G
V
I
M
P
I
S
E
I
S
R
R
I
K
A
L
N
Q
I
R
A
A
S
G
--
L
-
P
R
V
L
V
-
H
T
D
A
A
Q
A
L
G
K
RR
V
D
V
E
D
L
----
G
V
--
D
F
L
T
I
V
G
H
K
F
Y
G
P
R
-
I
G
A
L
Y
V
--
R
G
V
G
--
K
-------
L
T
P
L
Y
P
M
L
F
G
G
G
Q
E
R
N
F
R
P
G
T
E
N
T
P
M
I
A
G
L
G
K
A
A
D
L
V
S
E
N
C
E
T
Y
E
A
H
M
R
D
I
-
R
D
Y
---
L
E
E
R
L
E
A
E
FGKRIH
L
N
SR
F
P
G
V
E
R
L
----------
P
N
T
C
N
F
S
I
Q
G
SQ
L
R
G
Y
M
V
L
A
Q
C
Q
--
T
L
L
A
S
V
G
A
-------------------
P
V
D
V
A
R
N
A
V
R
L
S
V
---
G
R
S
T
T
R
A
E
V
D
L
I
V
Q
D
L
K
Q
A
V
N
Q
-------
29
PsiBlast_CBE
61.63
32%
-20
- C1 -
-
3VAX
2
?
B:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
-
A
D
I
V
L
H
W
M
T
A
--
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
--
P
Y
G
-
E
---
R
T
--
G
R
R----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
--
T
-
P
T
Y
-
L
-
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
D
--
L
T
T
-
P
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
-------
I
F
E
A
E
H
A
Q
W
-
Q
V
A
AQD
L
R
S
R
L
LAG------
L
A
--
S
T
S
F
Q
V
N
G
--
D
Q
D
-
H
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
TPG-----------------------------
12
PsiBlast_PDB
60.71
32%
-22
- C1 -
-
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
-
A
D
I
V
L
H
W
M
T
A
--
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
--
P
Y
G
-
E
---
R
T
--
G
R
R----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
--
T
-
P
T
Y
-
L
-
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
D
--
L
T
T
-
P
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
-------
I
F
E
A
E
H
A
Q
W
-
Q
V
A
A
Q
D
L
R
S
R
L
L
A
G
------
L
A
--
S
T
S
F
Q
V
N
G
--
D
Q
D
-
H
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
D
L
-
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
T
P
G-----------------------------
39
HHSearch
59.64
31%
-10
- C1 -
-
3VAX
1
?
A:
[22-379]
--
T
Y
L
D
A
A
A
T
T
R
V
D
Q
R
V
-
A
D
I
V
L
H
W
M
T
A
--
E
F
G
N
A
-
G
S
R
-
H
E
Y
G
I
R
A
K
R
G
V
E
R
A
R
E
Y
L
A
S
T
V
S
A
E
P
D
E
L
I
F
T
S
G
A
T
E
S
N
N
I
A
L
L
G
L
--
A
--
P
Y
G
E
R
---
T
G
--
R
R
-----
H
---
I
I
T
S
A
I
E
H
K
A
V
L
E
P
L
E
H
L
-
A
G
R
-
G
F
E
V
D
F
L
T
P
G
P
-
S
G
R
I
S
V
E
G
V
M
E
R
L
R
--
P
D
T
L
L
V
S
L
M
H
V
N
N
E
T
G
V
I
Q
P
V
A
E
L
A
Q
Q
L
---------
R
A
--
T
--
P
T
Y
L
-
H
V
D
A
A
Q
G
Y
G
K
--
V
P
G
-
D
L
T
-
T
-
P
I
--
D
M
I
S
I
S
G
H
K
I
G
A
P
K
G
V
G
A
L
V
T
--
R
R
R
E
--
E
MDDERVP
L
E
P
I
---
M
F
G
G
G
Q
E
R
K
L
R
P
G
T
L
P
V
P
L
I
M
G
L
A
E
A
A
K
I
F
E
A
E
H
A
Q
W
Q
V
A
A
Q
D
L
-
R
S
R
---
L
L
A
G
L
---------
A
S
--
T
-
S
F
Q
V
N
G
--
D
Q
D
-
H
V
V
P
H
I
L
N
L
S
F
E
D
--
V
D
A
E
A
F
L
V
T
L
K
-
D
L
V
A
V
A
T
G
S
A
S
-
T
S
A
S
F
T
P
S
H
V
L
R
A
M
G
L
P
E
E
A
A
S
K
S
L
R
F
S
W
---
T
P
G
--------------------------