@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKN6: (2017-10-27 )
MMLTSKASLRLTLLASAIFLVACQPKSDPKESEDQQKPAVVEQKPVELTLKGETVPSKVTLPDCDGKTCPEFTVARLQSNFPFIDKIIDQQVLKALGQILEIAEPDAKAAQADKKTEASTAAATEQQDSFDAQVQRYANSFIDLDNDLKALSSNHQINLLVKPKIIQSQGKVVTVVVNSSSYLGGAHGSAAQQYYNFDLKKEKQVKLEGLLRPEKKAALEKLAHEAFKAWVTDSKLVNSVSEYEQAWPFKLTENFLLGDQGLILQYGEYEIGPYVVGLPRLVIPYDQLQDVLKEEYLPQPKAKPASTPAVKSTS
Atome Classification :
(20 SA)
---....------------.....10........20........30..-....---..40..-......50........60........70.......-.-80........90...-.....100.......110......-.-120....-..---.130.......140.......150----.--........160...---..-..170.-.......180......-.190......---.200......-----.-210..-.--....220.......230..--...-..-240---.....---...---250-----.----.......260...--.....270.......280........290...-....300.......310..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MMLT------------SKA
S
L
R
L
T
L
L
AS
A
I
F
L
V
A
CQPKSDPKESE-DQQK---PAVVEQ-K
P
V
E
L
T
L
KGETVPSKVTLPDCDGKTC
P
E
F
T
V
A
R
L
Q-S-NF
P
F
I
D
K
I
I
D
Q
Q
V
L
K
-
A
L
G
Q
I
L
E
IAEPDAKAAQADKKTEA-S-TAAATEQ-QD---
S
F
D
A
Q
V
Q
R
Y
A
N
S
F
IDLD
N
D
L
K
A
------L--SSN
H
Q
I
N
L
L
V
KP
K
I
---IQ-SQG
K
-
V
-
V
T
V
V
VNSSSYLGGAH
G
-
S
A
A
Q
Q
YYNFD---LKKE
K
Q
V
K
L
E
-----G-LLR
P
E
-
K
--
K
A
A
L
E
K
L
A
H
E
A
F
K
A
WVT
D
S
--
K
L
V
-
N
S
-
V
S
----
E
Y
E
QA---WPF---KL------T----ENFLLGDQ-
G
L
I
L
--QYGEYEIG
P
Y
V
VGLPR-LVI
P
Y
D
Q
L
Q
D
V
L
K
E
E-YLPQPKAKPASTPAVKSTS
18
HHSearch
71.89
18%
3
- C2 -
-
3S5T
3
?
A:
[34-259]
-------------------------------------------------------------------------------------
P
A
C
N
L
T
I
N
F
A
Y
P
V
-
K
S
T
D
N
K
L
K
D
S
L
N
S
Y
F
I
A
-
A
C
F
G
E
G
Y
I
-
G
E
---------------------
K
P
-
A
Q
---
V
V
K
E
Y
T
E
H
Y
V
K
E
Y
R
T
D
L
E
P
M
Y
A
E
D
E
K
N
K-SI
G
A
W
Y
S
Y
Y
K
G
I
E
S
H
V
---
Q
L
-
Y
Y
K
N
-
L
-
L
V
Y
R
I
N
Y
N
E
Y
T
G
G
A
H
G
-
I
Y
M
T
T
F
L
N
M
D
---
L
I
N
L
R
P
L
K
L
D
-----
D
-
I
F
T
G
D
-
Y
--
K
E
A
L
T
D
L
L
W
N
Q
L
M
A
D
K
K
V
T
T
H
E
A
L
-
E
D
-
M
-----
G
Y
G
S
T
---
G
D
I
---
A
P
------
T
----
E
N
F
Y
L
D
K
D
-
G
I
T
F
--
Y
Y
N
V
Y
D
I
T
P
Y
A
M
G
P
V
E
-
I
K
I
P
Y
E
M
M
E
H
M
L
G
S
N
-
P
I
I
----------------
7
Fugue
69.67
25%
18
- C- -
-
4E72
-
?
A:
[26-247]
----------------------------------------------------------------
G
L
D
D
P
L
P
T
E
R
L
A
S
E
H
L
K
P
G
C
Q
G
E
Q
C
P
L
V
N
I
D
T
L
K
F
P
-
D
E
P
Q
L
D
P
I
V
E
R
A
L
L
E
M
T
R
T
P
L
P
A
S
L
A
A
Y
E
R
Q
F
L
D
S
-----------------------------------------------------
A
E
P
G
W
S
S
Y
L
Q
A
K
V
---
R
E
-
Q
H
D
G
-
L
-
V
I
I
E
L
S
S
Y
L
F
T
G
G
A
H
G
M
P
-
G
R
G
F
I
N
Y
D
---
R
R
Q
H
K
V
L
S
L
Q
-----
D
M
L
V
-
P
G
-
Q
--
E
E
A
F
W
K
Q
A
E
L
A
H
K
A
W
L
L
A
N
--
K
L
--
D
Q
-
D
A
----
D
F
Q
K
T
---
W
P
F
---
Q
R
------
T
----
P
H
V
A
L
T
F
G
-
A
V
T
L
--
K
Y
D
A
Y
S
I
A
P
Y
S
Y
A
H
P
E
-
L
K
I
P
Y
P
R
L
N
G
I
V
K
P
N
-
L
F
P
G
R
--------------
20
HHSearch
67.88
24%
-112
- C2 -
-
3CYG
-
?
B:
[103-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
P
Y
E
A
Y
V
S
V
D
V
---
R
Y
-
E
G
K
D
-
F
-
L
S
F
V
V
Y
Y
Y
Q
F
T
G
G
A
H
G
-
I
T
F
F
E
T
Y
N
I
D
---
L
K
N
S
K
V
L
K
L
Y
-----
D
-
I
I
K
E
E
-
A
--
E
D
T
I
K
S
N
I
L
K
Q
I
E
Q
N
N
T
----
D
F
F
-
P
D
--
A
----
P
M
N
I
L
---
K
D
D
---
I
F
------
S
----
R
E
F
T
I
S
K
D
-
G
L
I
I
--
M
Y
P
H
Y
D
L
A
P
Y
A
S
G
M
P
E
-
F
V
I
P
W
N
V
I
E
K
F
L
-----------------------
19
HHSearch
64.54
24%
-79
- C2 -
-
3CYG
-
?
A:
[103-249]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
T
P
Y
E
A
Y
V
S
V
D
V
---
R
Y
-
E
G
K
D
-
F
-
L
S
F
V
V
Y
Y
Y
Q
F
T
G
G
A
H
G
-
I
T
F
F
E
T
Y
N
I
D
---
L
K
N
S
K
V
L
K
L
Y
-----
D
-
I
I
K
E
E
-
A
--
E
D
T
I
K
S
N
I
L
K
Q
I
E
Q
N
N
T
----
D
F
F
-
P
D
--
A
----
P
M
N
I
L
---
K
D
D
---
I
F
------
S
----
R
E
F
T
I
S
K
D
-
G
L
I
I
--
M
Y
P
H
Y
D
L
A
P
Y
A
S
G
M
P
E
-
F
V
I
P
W
N
V
I
E
K
F
L
K
Y
D
-
I
L
S
L
L
K
E
G
-----------
17
HHSearch
62.33
27%
-37
- C- -
-
4E72
-
?
A:
[30-247]
--------------------------------------------------------------------
P
L
P
T
E
R
L
A
S
E
H
L
K
P
G
C
Q
G
E
Q
C
P
L
V
N
I
D
T
L
K
-
F
P
D
E
P
Q
L
D
P
I
V
E
R
A
L
L
E
-
M
T
R
----------------------------------------
T
P
L
P
A
S
L
A
A
Y
E
R
Q
F
L
D
------------
S
A
E
P
G
W
S
S
Y
L
Q
A
K
V
---
R
E
-
Q
H
D
G
-
L
-
V
I
I
E
L
S
S
Y
L
F
T
G
G
A
H
G
-
M
P
G
R
G
F
I
N
Y
D
---
R
R
Q
H
K
V
L
S
L
Q
-----
D
-
M
L
V
P
G
-
Q
--
E
E
A
F
W
K
Q
A
E
L
A
H
K
A
W
L
L
A
N
--
K
L
D
-
Q
D
--
A
----
D
F
Q
K
T
---
W
P
F
---
Q
R
------
T
----
P
H
V
A
L
T
F
G
-
A
V
T
L
--
K
Y
D
A
Y
S
I
A
P
Y
S
Y
A
H
P
E
-
L
K
I
P
Y
P
R
L
N
G
I
V
K
P
N
-
L
F
P
G
R
--------------
1
PsiBlast_PDB
61.58
25%
-37
- C- -
-
4E72
-
?
A:
[31-245]
---------------------------------------------------------------------
L
P
T
E
R
L
A
S
E
H
L
K
P
G
C
Q
G
E
Q
C
P
L
V
N
I
D
T
L
K
F
P
-
D
E
P
Q
L
D
P
I
V
E
R
A
L
L
E
-
M
T
R
----
T
P
L
P
A
S
L
A
A
--------------------------------
Y
E
R
Q
F
L
D
----------------
S
A
E
P
G
W
S
S
Y
L
Q
A
K
V
---
R
E
-
Q
H
D
G
-
L
-
V
I
I
E
L
S
S
Y
L
F
T
G
G
A
H
G
-
M
P
G
R
G
F
I
N
Y
D
---
R
R
Q
H
K
V
L
S
L
Q
-----
D
-
M
L
V
P
G
-
Q
--
E
E
A
F
W
K
Q
A
E
L
A
H
K
A
W
L
L
A
N
--
K
L
--
D
Q
-
D
A
----
D
F
Q
K
T
---
W
P
F
---
Q
R
------
T
----
P
H
V
A
L
T
F
G
-
A
V
T
L
--
K
Y
D
A
Y
S
I
A
P
Y
S
Y
A
H
P
E
-
L
K
I
P
Y
P
R
L
N
G
I
V
K
P
N
-
L
F
P
----------------
8
Fugue
61.01
20%
26
- C2 -
-
3CYG
-
?
A:
[36-250]
------------------------------------------------------------
L
R
M
K
V
F
E
I
V
K
S
S
T
E
N
E
I
-----------------
V
R
I
H
-
V
-
E
L
P
R
L
K
Y
L
K
D
S
N
F
E
E
-
K
F
N
S
E
V
E
E
K
I
K
K
F
V
N
E
V
K
G
I
A
Q
E
D
-
H
-
D
K
D
-----------------------------------------
V
Q
H
T
P
Y
E
A
Y
V
S
V
D
V
---
R
Y
-
E
G
K
D
-
F
-
L
S
F
V
V
Y
Y
Y
Q
F
T
G
G
A
H
G
-
I
T
F
F
E
T
Y
N
I
D
---
L
K
N
S
K
V
L
K
L
Y
-----
D
-
I
I
K
E
E
-
A
--
E
D
T
I
K
S
N
I
L
K
Q
I
E
Q
N
N
T
D
F
--
F
P
D
-
A
P
M
N
I
----
L
K
-------
D
D
---
I
F
------
S
----
R
E
F
T
I
S
K
D
-
G
L
I
I
--
M
Y
P
H
Y
D
L
A
P
Y
A
S
G
M
P
E
-
F
V
I
P
W
N
V
I
E
K
F
L
K
Y
D
-
I
L
S
L
L
K
E
G
H
----------
3
PsiBlast_PDB
60.68
30%
-36
- C2 -
-
3S5T
1
?
A:
[137-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
Y
N
E
Y
T
G
G
A
H
G
-
I
Y
M
T
T
F
L
N
M
D
---
L
I
N
L
R
P
L
K
L
D
-----
D
-
I
F
T
G
D
-
Y
--
K
E
A
L
T
D
L
L
W
N
Q
L
M
A
---
D
K
--
K
V
T
-
T
H
-
E
A
L
E
D
M
G
Y
G
S
T
---
G
D
I
---
A
P
------
T
----
E
N
F
Y
L
D
K
D
-
G
I
T
F
--
Y
Y
N
V
Y
D
I
T
P
Y
A
M
G
P
V
E
-
I
K
I
P
Y
E
M
M
E
H
M
L
-----------------------
2
PsiBlast_PDB
60.28
28%
-53
- C2 -
-
3CYG
-
?
A:
[114-243]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
-
Y
E
G
K
D
F
-
L
S
F
V
V
Y
Y
Y
Q
F
T
G
G
A
H
G
-
I
T
F
F
E
T
Y
N
I
D
---
L
K
N
S
K
V
L
K
L
Y
-----
D
-
I
I
K
E
E
-----------
A
E
D
T
I
K
S
N
I
L
K
Q
--
I
E
Q
-
N
N
-
T
D
----
F
F
P
D
A
----
P
M
---
N
I
L
K
DDIF
S
----
R
E
F
T
I
S
K
D
-
G
L
I
I
--
M
Y
P
H
Y
D
L
A
P
Y
A
S
G
M
P
E
-
F
V
I
P
W
N
V
I
E
K
F
L
K
Y
D
-
I
L
-----------------
10
Fugue
49.93
11%
4
- C2 -
-
2HHI
-
MP64_MYCTU
A:
[3-206]
--------------------------------------------------------------------------------------------------------------
P
K
T
Y
C
E
-
E
L
K
G
T
D
T
G
Q
A
C
Q
I
Q
M
S
D
P
A
Y
N
I
N
I
-
S
-
L
P
S
Y
Y
P
D
-
Q
K
---
S
L
E
N
Y
I
A
Q
T
R
D
K
F
L
S
A
A
T
S
S
T
P
------
R
--
E
A
P
Y
E
L
N
I
T
S
A
T
Y
Q
---
S
A
I
P
P
R
G
-
T
-
Q
A
V
V
L
K
V
Y
Q
N
A
G
G
T
H
P
-
T
T
T
Y
K
A
F
D
W
D
---
Q
A
Y
R
K
P
I
T
Y
D
-----
T
-
L
W
Q
A
D
-
T
--
D
P
--
L
P
V
V
F
P
I
V
Q
G
E
L
S
K
Q
--
T
G
Q
-
Q
V
-
S
I
----
A
P
N
A
G
---
L
D
P
---
V
N
------
Y
----
Q
N
F
A
V
T
N
D
-
G
V
I
F
--
F
F
N
P
G
E
L
L
P
E
A
A
G
P
T
Q
-
V
L
V
P
R
S
A
I
D
S
M
L
A
----------------------
22
HHSearch
48.26
17%
-11
* C2 *
-
5JEN
-
LYSC_CHICK (first)
A:
[124-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
L
S
I
Y
S
D
Y
E
T
---
V
T
-
D
T
P
D
-
L
-
L
S
I
R
R
N
I
E
--
T
T
Q
A
S
S
-
Y
T
Q
S
R
Y
I
T
I
D
---
K
K
N
D
I
L
L
T
L
K
-----
S
-
L
F
K
D
E
R
Y
--
I
K
V
I
S
Q
N
I
K
E
Q
M
K
Q
Q
M
K
E
D
--
P
N
-----
K
I
----
Y
W
L
T
D
EDA
E
P
F
KTI
L
P
------
D
----
Q
T
F
Y
I
T
E
D
H
K
L
V
I
--
S
F
D
E
Y
E
V
A
P
G
Y
M
G
V
T
E
-
F
T
I
P
T
G
V
I
S
N
L
L
V
G
E
R
Y
I
R
----------------
16
Fugue
45.53
15%
49
- C1 -
-
3DSM
-
?
A:
[1-327]
A
S
G
L
F
I
T
N
EGNFQYSN
A
T
L
S
Y
Y
D
P
A
T
C
E
V
E
N
E
V
F
Y
R
A
N
G
F
K
L
G
D
V
A
Q
S
M
V
I
R
D
G
I
G
W
I
V
V
N
N
-
S
H
V
I
F
A
I
D
I
N
T
F
K
E
V
G
R
I
T
G
F
T
S
P
R
Y
I
H
F
L
S
-----
D
-
E
K
A
Y
V
T
Q
I
W
D
Y
R
I
F
I
-
I
N
--------
P
K
T
Y
E
I
T
G
Y
I
E
C
P
D
M
D
M
E
S
G
S
T
E
Q
M
V
Q
Y
GK
Y
V
Y
V
N
C
W
S
Y
Q
N
R
I
L
K
I
D
T
E
T
D
K
------
V
--
V
D
E
L
T
I
G
--
I
Q
P
T
S
---
L
V
M
D
K
Y
N
-
K
M
W
T
I
T
--
D
G
G
Y
E
G
S
P
Y
G
-
Y
E
A
P
S
L
Y
R
I
D
AET
F
T
V
E
K
Q
F
K
F
K
-----
L
-
G
D
W
P
S
------
E
V
Q
L
N
G
T
R
D
T
L
Y
W
I
N
N
D
--
I
W
R
M
P
V
-
E
A
----
D
R
V
P
V
---
R
P
F
---
L
E
------
F
----
R
D
--
T
K
Y
Y
-
G
L
T
V
NP
N
N
G
E
V
Y
V
A
D
A
I
D
Y
Q
Q
Q
G
I
V
Y
R
Y
S
P
Q
G
K
L
I
D
E
F
-
Y
V
G
I
I
P
G
A
F
C
W
K
L
E
H
H
H
H
H
21
HHSearch
43.49
13%
15
- C2 -
-
2HHI
-
MP64_MYCTU
A:
[67-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
Y
E
L
N
I
T
S
A
T
Y
Q
S
A
I
-
P
P
R
G
-
T
-
Q
A
V
V
L
K
V
Y
Q
N
A
G
G
T
H
P
-
T
T
T
Y
K
A
F
D
W
D
---
Q
A
Y
R
K
P
I
T
Y
D
-----
T
-
L
W
Q
A
D
-
T
DP
L
P
V
V
F
P
I
V
Q
G
E
L
S
K
Q
T
G
Q
Q
--
V
S
I
-
A
P
--
N
----
A
G
------
L
D
P
---
V
N
------
Y
----
Q
N
F
A
V
T
N
D
-
G
V
I
F
--
F
F
N
P
G
E
L
L
P
E
A
A
G
P
T
Q
-
V
L
V
P
R
S
A
I
D
S
M
L
A
----------------------
11
Fugue
42.02
25%
-103
- C2 -
-
2ROD
-
APR_MOUSE
B:
[17-43]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-
E
L
P
P
E
-
F
--
A
A
Q
L
R
K
I
G
D
K
V
Y
C
T
W
S
A
P
D
--
M
----------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
38.37
26%
-47
- C2 -
-
5JEN
-
LYSC_CHICK (first)
A:
[208-264]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
T
D
------------------
E
D
A
---
E
P
F
---
K
T
------
I
LPD
Q
T
F
Y
I
T
E
D
H
-
K
L
V
I
--
S
F
D
E
Y
E
V
A
P
G
Y
M
G
V
T
E
-
F
T
I
P
T
G
V
I
S
N
L
L
-----------------------
5
PsiBlast_PDB
37.19
29%
14
- C2 -
-
3QAE
1
?
A:
[37-131]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
W
N
G
F
S
----
K
K
S
Y
Q
E
R
L
E
L
L
K
A
Q
A
-
L
L
S
P
E
-
R
--
Q
A
S
L
E
K
--
D
E
Q
M
S
V
T
V
A
D
Q
--
L
S
E
-
N
V
-
V
G
----
T
F
--
S
---
L
P
Y
---
S
L
------
V
----
P
E
V
L
V
N
G
Q
----------
E
Y
T
V
-
P
Y
V
T
E
E
P
S
-
V
V
A
A
A
S
Y
A
S
K
I
I
K
R
---------------------
6
PsiBlast_PDB
36.00
29%
14
- C2 -
-
3QAU
-
?
A:
[37-131]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
W
N
G
F
S
----
K
K
S
Y
Q
E
R
L
E
L
L
K
A
Q
A
-
L
L
S
P
E
-
R
--
Q
A
S
L
E
K
--
D
E
Q
M
S
V
T
V
A
D
Q
--
L
S
E
-
N
V
-
V
G
----
T
F
--
S
---
L
P
Y
---
S
L
------
V
----
P
E
V
L
V
N
G
Q
----------
E
Y
T
V
-
P
Y
V
T
E
E
P
S
-
V
V
A
A
A
S
Y
A
S
K
I
I
K
R
---------------------
29
HHSearch
31.55
24%
-28
- C2 -
-
3VEJ
-
MDY2_YEAST
A:
[2-22]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
-
L
T
V
P
W
D
D
I
E
A
L
L
K
N
N
-
F
E
N
D
---------------
28
HHSearch
30.55
24%
-22
- C2 -
-
3VEJ
-
B:
[2-22]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
-
L
T
V
P
W
D
D
I
E
A
L
L
K
N
N
-
F
E
N
D
---------------
14
Fugue
25.47
12%
85
- C2 -
-
3T97
-
NUP62_RAT
A:
[364-419]
-------------------------------------------------------------------------------------------------------------
W
D
R
T
L
I
E
-
N
G
E
K
I
T
S
L
H
R
E
V
E
K
V
K
L
D
Q
K
R
L
D
Q
-
E
-
L
D
F
I
L
S
Q
-
Q
K
---
E
L
E
D
L
L
S
P
L
E
E
S
V
K
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------