@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKQ4: (2017-10-28 )
MVSYSASYLPRMQQNLTLLQHYHENKENCMSFSMTKLSAALLLTSSLVGCAAVVKTPYQAPAVQVPGSFQYDKAKAKTASVEQYSDHWWTLFGDAQLNQLVTNVLERNSDLAVAGITLKQARLQADLTANKQGLRTSSSVSTGHSFDLNSGDDSAKGLSMSAGVSYELDLFGKLARQTEASKWEALATEQDLQSTGQSLIATTAKLYWQLGYLNERYATAQQSLATSQKLYQLVQTQYKAGAVSGLDLTQAEQSVQSQKASLSQIEQQLVETRTAIAVLLHEPVQQLNIQEPQRLPRTALPAIGAGLPADILSRRPDLQAAELRLRKALATKDATKASYYPSISLTSSLGSSSTSLTELLRNPALTLGASLSLPFLQYNDIKKDIAISNLDYEKAIIQYRQTLYQAFADVENALSSRTELDKQVALQERNVELAEKTERLTEVRYRYGAVALKTLLDAQQTTRTARLSLVETKQSQYNAYVTLMQALGGSPVKELPQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.-.......70.......---.80..---......90....-....100.......110.....---------..120.......130----.......140-----....----....150---.-----......---..160.-.---.-----..---..170.......180.......190.......200......--.210.......220.......230.......240...-....250--.----........260.......270.......280........-.-290-.-......--.300-------.-.......310.......320.......330.......340.......350.......--360.--.--.--.--.--...--.370...---------....380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MVSY
S
A
S
Y
L
P
R
M
Q
Q
N
L
T
L
L
Q
H
Y
HEN
K
E
N
C
M
S
F
S
M
T
K
L
S
A
A
L
L
L
T
S
S
L
V
G
C
A
A
V
VKTPYQAP
A
-
V
QVPGSFQYDKAKAKT---A
S
V
E
Q---YSD
H
W
W
T
L
FG
D
A
-
Q
L
N
Q
L
V
T
N
V
L
ERNSD
L
A
V
A
G
I
T
---------
L
K
Q
A
R
L
QADLTANKQ----GLRTSSSVS------TG
H
S
----FDLNS-----G-----DDSAKG---LSMSAG-V---
S
-----
Y
E
---
L
D
L
F
G
K
L
A
R
Q
TEA
S
K
W
E
A
L
A
T
E
Q
D
L
Q
S
T
G
Q
S
L
I
A
T
T
A
K
L
Y
W--QLGYL
N
E
R
Y
A
T
A
Q
Q
S
L
A
T
S
Q
K
L
Y
Q
L
V
Q
T
Q
Y
KAGAVSG-L
D
L
T
Q
----
A
----
E
Q
S
V
Q
S
Q
K
A
S
L
S
Q
I
E
Q
Q
L
V
E
T
R
T
A
I
A
V
L
L
--HE
P
V
Q
QLN-I-Q-
E
-
P
-QRL
P
R
T
--ALP--------A-IGAGL
P
A
D
I
L
SRRPD
L
Q
A
A
E
L
R
L
R
K
A
LATKDATKASYYP
S
I
S
L
TSSLGSS
S
T
S
L
T
E
L
--
L
--R--N--P--A--L--TLG--ASLSL
P
F
---------
L
QYNDI
K
K
D
I
A
ISNL
D
Y
E
K
A
I
I
Q
Y
R
Q
T
L
Y
Q
A
F
A
D
V
E
N
A
L
S
S
R
T
E
L
D
K
Q
V
A
L
Q
ERN
V
E
L
A
E
K
T
E
R
L
T
E
V
R
Y
R
Y
G
A
V
A
L
K
T
L
L
D
A
Q
Q
TT
R
T
A
R
L
S
L
V
ET
K
Q
S
Q
Y
N
A
Y
V
T
L
M
Q
A
LGGS
P
V
K
ELPQ
24
Fugue
73.33
27%
-1
- C6 -
-
4MT0
-
?
A:
[1-445]
-----
C
T
M
I
P
Q
----------------------------------------------
Y
E
Q
P
K
-
V
E
V
A
E
T
F
Q
N
D
T
S
V
S
S
I
---
R
A
V
D
L
------
G
W
H
D
Y
F
A
D
P
-
R
L
Q
K
L
I
D
I
A
L
E
R
N
T
S
L
R
T
A
V
L
N
---------
S
E
I
Y
R
K
Q
Y
M
I
E
R
N
N
L
----
L
P
T
L
A
A
N
A
N
------
G
S
R
Q
----
G
S
L
S
G
-----
G
-----
N
V
S
S
S
Y
---
N
V
G
L
G
A
-
A
---
S
-----
Y
E
---
L
D
L
F
G
R
V
R
S
S
S
E
A
A
L
Q
G
Y
F
A
S
V
A
N
R
D
A
A
H
L
S
L
I
A
T
V
A
K
A
Y
F
--
N
E
R
Y
A
E
E
A
M
S
L
A
Q
R
V
L
K
T
R
E
E
T
Y
N
A
V
R
I
A
V
Q
G
R
R
D
F
R
-
R
R
P
A
P
----
A
----
E
A
L
I
E
S
A
K
A
D
Y
A
H
A
A
R
S
R
E
Q
A
R
N
A
L
A
T
L
I
--
N
R
P
I
P
E
-
D
-
L
-
P
-
A
-
G
-
L
P
L
D
K
Q
--
F
F
V
--------
E
K
L
P
A
G
L
S
S
E
V
L
L
D
R
P
D
I
R
A
A
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
R
L
T
G
S
V
G
T
G
S
V
E
L
G
G
L
--
F
--
K
--
S
GT
G
--
V
--
W
--
A
F
A
--
P
S
I
T
L
P
I
---------
F
T
W
G
T
N
K
A
N
L
D
V
A
K
L
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
A
F
Q
D
V
A
N
A
L
A
A
R
E
Q
L
D
K
A
Y
D
A
L
S
K
Q
S
R
A
S
K
E
A
L
R
L
V
G
L
R
Y
K
H
G
V
S
G
A
L
D
L
L
D
A
E
R
S
S
Y
S
A
E
G
A
A
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
G
G
G
L
K
R
D
T
Q
T
2
PsiBlast_PDB
71.98
32%
24
- C6 -
-
4Y1K
1
OPRM_PSEAE
A:
[7-449]
---------------------------------------------------------
Y
Q
R
P
E
-
A
P
V
A
A
A
Y
P
Q
G
Q
A
Y
G
Q
N
TGA
A
A
V
P
A
---
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
--
Q
R
A
----
D
L
F
P
R
I
G
V
D
------
G
S
G
T
----
R
Q
R
L
P
-----
G
-----
D
L
S
T
T
G
S
P
A
I
S
S
Q
Y
G
-
V
---
T
L
G
T
T
A
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
I
P
A
-
N
-
L
-
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
--
D
AG
S
--
G
--
S
--
W
--
L
F
Q
--
P
S
I
N
L
P
I
FTAG
S
L
R
A
S
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
--
Y
E
K
A
I
----
Q
T
---
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
-------
22
PsiBlast_CBE
71.94
32%
22
- C6 -
-
4Y1K
1
OPRM_PSEAE
B:
[7-449]
---------------------------------------------------------
Y
Q
R
P
E
-
A
P
V
A
A
A
Y
P
Q
G
Q
A
Y
G
Q
N
TGA
A
A
V
P
A
---
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
--
Q
R
A
----
D
L
F
P
R
I
G
V
D
------
G
S
G
T
----
R
Q
R
L
P
-----
G
-----
D
L
S
T
T
G
SPA
I
S
S
Q
Y
G
-
V
---
T
LGTTA
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
I
P
A
-
N
-
L
-
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
--
D
AG
S
--
G
--
S
--
W
--
L
F
Q
--
P
S
I
N
L
P
I
FTAGSLRAS
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
--
Y
E
K
A
I
----
Q
T
---
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
-------
21
PsiBlast_CBE
71.80
32%
21
- C6 -
-
4Y1K
1
OPRM_PSEAE
C:
[7-449]
---------------------------------------------------------
Y
Q
R
P
E
-
A
P
V
A
A
A
Y
P
Q
G
Q
A
Y
G
Q
N
TGA
A
A
V
P
A
---
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
--
Q
R
A
----
D
L
F
P
R
I
G
V
D
------
G
S
G
T
----
R
Q
R
L
P
-----
G
-----
D
L
S
T
T
G
SPA
I
S
S
Q
Y
G
-
V
---
T
LGTTA
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
I
P
A
-
N
-
L
-
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
--
D
AG
S
--
G
--
S
--
W
--
L
F
Q
--
P
S
I
N
L
P
I
FTAGSLRAS
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
--
Y
E
K
A
I
----
Q
T
---
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
-------
1
PsiBlast_PDB
71.28
32%
21
- C6 -
-
1WP1
-
OPRM_PSEAE
A:
[7-449]
---------------------------------------------------------
Y
Q
R
P
E
-
A
P
V
A
A
A
Y
P
Q
G
Q
A
Y
G
Q
N
TGA
A
A
V
P
A
---
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
--
Q
R
A
----
D
L
F
P
R
I
G
V
D
------
G
S
G
T
----
R
Q
R
L
P
-----
G
-----
D
L
S
T
T
G
S
P
A
I
S
S
Q
Y
G
-
V
---
T
L
G
T
T
A
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
I
P
A
-
N
-
L
-
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
--
D
AG
S
--
G
--
S
--
W
--
L
F
Q
--
P
S
I
N
L
P
I
F
TAG
S
L
R
A
S
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
--
Y
E
K
A
I
----
Q
T
---
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
-------
4
PsiBlast_PDB
69.86
29%
16
- C6 -
-
4MT0
-
?
A:
[7-438]
---------------------------------------------------------
Y
E
Q
P
K
-
V
E
V
A
E
T
F
Q
N
D
T
S
---
V
---
S
S
I
R
A
---
V
D
L
G
W
H
D
Y
F
A
D
P
-
R
L
Q
K
L
I
D
I
A
L
E
R
N
T
S
L
R
T
A
V
L
N
S
E
I
Y
R
K
Q
Y
M
I
E
R
N
N
L
L
P
T
L
A
A
N
A
N
----
G
S
R
Q
G
S
L
S
G
------
G
N
V
S
----
S
S
Y
N
V
-----
G
-----
L
G
A
A
----------------
S
-----
Y
E
---
L
D
L
F
G
R
V
R
S
S
S
E
A
A
L
Q
G
Y
F
A
S
V
A
N
R
D
A
A
H
L
S
L
I
A
T
V
A
K
A
Y
F
--
N
E
R
Y
A
E
E
A
M
S
L
A
Q
R
V
L
K
T
R
E
E
T
Y
N
A
V
R
I
-----
A
V
Q
G
R
R
D
F
R
R
R
P
A
P
A
----
E
A
L
I
E
S
A
K
A
D
Y
A
H
A
A
R
S
R
E
Q
A
R
N
A
L
A
T
L
I
--
N
R
P
I
-----------
P
-
E
D
L
P
-
A
--
G
L
P
LDKQFFV
E
K
-
L
P
A
G
L
S
S
E
V
L
L
D
R
P
D
I
R
A
A
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
R
L
T
G
S
V
G
T
G
S
V
E
L
G
G
L
--
F
--
K
--
S
GT
G
--
V
--
W
--
A
F
A
--
P
S
I
T
L
P
I
---------
F
T
W
G
T
N
K
A
N
L
D
V
A
K
L
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
A
F
Q
D
V
A
N
A
L
A
A
R
E
Q
L
D
K
A
Y
D
A
L
S
K
Q
S
R
A
S
K
E
A
L
R
L
V
G
L
R
Y
K
H
G
V
S
G
A
L
D
L
L
D
A
E
R
S
S
Y
S
A
E
G
A
A
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
G
G
G
-------
39
HHSearch
69.23
31%
6
- C6 -
-
4Y1K
1
OPRM_PSEAE
C:
[33-453]
------------------------------------------------------------------------------------
V
P
A
---
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
--
Q
R
A
----
D
L
F
P
R
I
G
V
D
------
G
S
G
T
----
R
Q
R
L
P
-----
G
DLSTT
G
S
P
A
I
S
---
S
Q
Y
G
V
T
-
L
GTT
A
-----
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
-
I
P
A
N
-
L
-
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
DA
G
--
S
--
G
S-
W
--
L
---
F
Q
--
P
S
I
N
L
P
I
---------
F
T
A
G
S
L
R
A
S
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
Y
E
K
A
I
Q
T
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
W
N
Q
Q
---
23
Fugue
68.84
28%
32
- C6 -
-
1WP1
-
OPRM_PSEAE
A:
[1-456]
---------------------------------------------------
C
S
L
I
P
D
Y
Q
R
P
E
-
A
P
V
A
A
A
Y
P
Q
G
Q
A
Y
G
Q
N
---
T
G
A
A
A
VPA
A
D
I
G
W
R
E
F
F
R
D
P
-
Q
L
Q
Q
L
I
G
V
A
L
E
N
N
R
D
L
R
V
A
A
L
N
---------
V
E
A
F
R
A
Q
Y
R
I
Q
R
A
D
L
----
F
P
R
I
G
V
D
G
S
G
T
R
Q
R
L
P
G
D
L
----
S
T
T
G
S
-----
P
-----
A
I
S
S
Q
Y
---
G
V
T
L
G
T
-
T
---
A
-----
W
E
---
L
D
L
F
G
R
L
R
S
L
R
D
Q
A
L
E
Q
Y
L
A
T
E
Q
A
Q
R
S
A
Q
T
T
L
V
A
S
V
A
T
A
Y
L
--
T
L
K
A
D
Q
A
Q
L
Q
L
T
K
D
T
L
G
T
Y
Q
K
S
F
D
L
T
Q
R
S
Y
D
V
G
V
A
S
A
-
L
D
L
R
Q
----
A
----
Q
T
A
V
E
G
A
R
A
T
L
A
Q
Y
T
R
L
V
A
Q
D
Q
N
A
L
V
L
L
L
--
G
S
G
I
P
A
N
L
---
P
-
Q
-
G
-
L
G
L
D
Q
T
--
L
L
T
--------
E
-
V
P
A
G
L
P
S
D
L
L
Q
R
R
P
D
I
L
E
A
E
H
Q
L
M
A
A
N
A
S
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
A
N
A
G
T
M
S
R
Q
L
S
G
L
--
F
--
D
--
A
--
G
--
S
--
G
S
W
L
F
Q
--
P
S
I
N
L
P
I
---------
F
T
A
G
S
L
R
A
S
L
D
Y
A
K
I
Q
K
D
I
N
V
A
Q
Y
E
K
A
I
Q
T
A
F
Q
E
V
A
D
G
L
A
A
R
G
T
F
T
E
Q
L
Q
A
Q
R
D
L
V
K
A
S
D
E
Y
Y
Q
L
A
D
K
R
Y
R
T
G
V
D
N
Y
L
T
L
L
D
A
Q
R
S
L
F
T
A
Q
Q
Q
L
I
T
D
R
L
N
Q
L
T
S
E
V
N
L
Y
K
A
L
G
G
G
W
N
Q
Q
T
V
T
8
PsiBlast_PDB
68.67
27%
5
- C6 -
-
4K34
-
CUSC_ECOLI
A:
[32-437]
--------------------------------------------------------------------------------------
Y
---
Q
N
A
G
W
R
T
F
F
V
D
N
-
Q
V
K
T
L
I
S
E
A
L
V
N
N
R
D
L
R
M
A
T
L
K
---------
V
Q
E
A
R
A
Q
Y
R
L
T
D
A
D
R
-----------------------------------------------------------
A
---
S
-----
F
D
---
L
D
F
F
G
R
L
K
N
M
S
E
A
E
R
Q
N
Y
L
A
T
E
E
A
Q
R
A
V
H
I
L
L
V
S
N
V
A
Q
S
Y
F
N
Q
Q
L
A
Y
--
A
Q
L
Q
I
A
E
E
T
L
R
N
Y
Q
Q
S
Y
A
F
V
E
K
Q
L
L
T
G
S
S
N
V
-
L
A
L
E
Q
----
A
----
R
G
V
I
E
S
T
R
S
D
I
A
K
R
Q
G
E
L
A
Q
A
N
N
A
L
Q
L
L
L
GS
Y
G
K
L
P
Q
A
Q
-
T
-
V
-
N
-
S
-
D
S
L
Q
S
V
--
K
L
P
------------
A
G
L
S
S
Q
I
L
L
Q
R
P
D
I
M
E
A
E
H
A
L
M
A
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
S
G
I
S
T
A
S
S
D
L
S
S
L
--
F
--
N
--
A
--
S
--
S
GM
W
--
N
F
I
--
P
K
I
E
I
P
I
---------
F
N
A
G
R
N
Q
A
N
L
D
I
A
E
I
R
Q
Q
Q
S
V
V
N
Y
E
Q
K
I
Q
N
A
F
K
E
V
A
D
A
L
A
L
R
Q
S
L
N
D
Q
I
S
A
Q
Q
R
Y
L
A
S
L
Q
I
T
L
Q
R
A
R
A
L
Y
Q
H
G
A
V
S
Y
L
E
V
L
D
A
E
R
S
L
F
A
T
R
Q
T
L
L
D
L
N
Y
A
R
Q
V
N
E
I
S
L
Y
T
A
L
----------
10
PsiBlast_PDB
68.37
28%
56
- C6 -
-
5IUY
4
?
A:
[8-442]
------------------------------------------------------
R
T
P
D
T
A
A
A
K
I
D
A
T
A
S
K
P
Y
D
R
S
R
--------------
F
E
S
L
W
W
K
Q
F
D
D
P
-
T
L
N
Q
L
V
E
Q
S
L
S
G
N
R
D
L
R
V
A
F
A
R
---------
L
R
A
A
R
A
L
R
D
D
V
A
N
D
R
F
P
V
V
T
S
R
A
S
A
D
I
G
------
K
G
Q
Q
----
P
G
V
T
E
-----
D
-----
R
V
N
S
E
R
---
Y
D
L
G
L
D
-
S
---
A
-----
W
E
---
L
D
L
F
G
R
I
R
R
Q
L
E
S
S
D
A
L
S
E
A
A
E
A
D
L
Q
Q
L
Q
V
S
L
I
A
E
L
V
D
A
Y
G
--
Q
L
R
G
A
Q
L
R
E
K
I
A
L
S
N
L
E
N
Q
K
E
S
R
Q
L
T
E
Q
L
R
D
A
G
V
G
A
E
-
L
D
V
L
R
----
A
----
D
A
R
L
A
A
T
A
A
S
V
P
Q
L
Q
A
E
A
E
R
A
R
H
R
I
A
T
L
L
--
G
Q
R
P
E
E
L
T
-
V
-
D
L
S
-
P
-
R
D
L
P
A
I
TK
A
L
P
------------
I
G
D
P
G
E
L
L
R
R
R
P
D
I
R
A
A
E
R
R
L
A
A
S
T
A
D
V
G
V
A
T
A
D
L
F
P
R
V
S
L
S
G
F
L
G
F
T
A
G
R
G
S
Q
I
--
G
--
S
--
S
--
A
A
R
A
--
W
--
S
V
G
--
P
S
I
S
W
A
A
---------
F
D
L
G
S
V
R
A
R
L
R
G
A
K
A
D
A
D
A
A
L
A
S
Y
E
Q
Q
V
L
L
A
L
E
E
S
A
N
A
F
S
D
Y
G
K
R
Q
E
R
L
V
S
L
V
R
Q
S
E
A
S
R
A
A
A
Q
Q
A
A
I
R
Y
R
E
G
T
T
D
F
L
V
L
L
D
A
E
R
E
Q
L
S
A
E
D
A
Q
A
Q
A
E
V
E
L
Y
R
G
I
V
A
I
Y
R
S
L
G
G
G
-------
11
PsiBlast_PDB
67.64
28%
58
- C6 -
-
5AZO
-
?
A:
[8-442]
------------------------------------------------------
R
T
P
D
T
A
A
A
K
I
D
A
T
A
S
K
P
Y
D
R
S
R
--------------
F
E
S
L
W
W
K
Q
F
D
D
P
-
T
L
N
Q
L
V
E
Q
S
L
S
G
N
R
D
L
R
V
A
F
A
R
---------
L
R
A
A
R
A
L
R
D
D
V
A
N
D
R
F
P
V
V
T
S
R
A
S
A
D
I
G
------
K
G
Q
Q
----
P
G
V
T
E
-----
D
-----
R
V
N
S
E
R
---
Y
D
L
G
L
D
-
S
---
A
-----
W
E
---
L
D
L
F
G
R
I
R
R
Q
L
E
S
S
D
A
L
S
E
A
A
E
A
D
L
Q
Q
L
Q
V
S
L
I
A
E
L
V
D
A
Y
G
--
Q
L
R
G
A
Q
L
R
E
K
I
A
L
S
N
L
E
N
Q
K
E
S
R
Q
L
T
E
Q
L
R
D
A
G
V
G
A
E
-
L
D
V
L
R
----
A
----
D
A
R
L
A
A
T
A
A
S
V
P
Q
L
Q
A
E
A
E
R
A
R
H
R
I
A
T
L
L
--
G
Q
R
P
E
E
L
T
-
V
-
D
L
S
-
P
-
R
D
L
P
A
I
TK
A
L
P
------------
I
G
D
P
G
E
L
L
R
R
R
P
D
I
R
A
A
E
R
R
L
A
A
S
T
A
D
V
G
V
A
T
A
D
L
F
P
R
V
S
L
S
G
F
L
G
F
T
A
G
R
G
S
Q
I
--
G
--
S
--
S
--
A
A
R
A
--
W
--
S
V
G
--
P
S
I
S
W
A
A
---------
F
D
L
G
S
V
R
A
R
L
R
G
A
K
A
D
A
D
A
A
L
A
S
Y
E
Q
Q
V
L
L
A
L
E
E
S
A
N
A
F
S
D
Y
G
K
R
Q
E
R
L
V
S
L
V
R
Q
S
E
A
S
R
A
A
A
Q
Q
A
A
I
R
Y
R
E
G
T
T
D
F
L
V
L
L
D
A
E
R
E
Q
L
S
A
E
D
A
Q
A
Q
A
E
V
E
L
Y
R
G
I
V
A
I
Y
R
S
L
G
G
G
-------
7
PsiBlast_PDB
67.61
27%
30
- C6 -
-
4K7R
1
CUSC_ECOLI
A:
[7-437]
---------------------------------------------------------
Y
Q
R
P
A
-
M
P
V
P
Q
Q
F
S
L
--------------
Y
---
Q
N
A
G
W
R
T
F
F
V
D
N
-
Q
V
K
T
L
I
S
E
A
L
V
N
N
R
D
L
R
M
A
T
L
K
---------
V
Q
E
A
R
A
Q
Y
R
L
T
D
A
D
R
----
Y
P
Q
L
N
G
E
G
S
------
G
S
W
S
----
G
N
L
K
G
-----
N
-----
T
A
T
T
R
E
---
F
S
T
G
L
N
-
A
---
S
-----
F
D
---
L
D
F
F
G
R
L
K
N
M
S
E
A
E
R
Q
N
Y
L
A
T
E
E
A
Q
R
A
V
H
I
L
L
V
S
N
V
A
Q
S
Y
F
N
Q
Q
L
A
Y
--
A
Q
L
Q
I
A
E
E
T
L
R
N
Y
Q
Q
S
Y
A
F
V
E
K
Q
L
L
T
G
S
S
N
V
-
L
A
L
E
Q
----
A
----
R
G
V
I
E
S
T
R
S
D
I
A
K
R
Q
G
E
L
A
Q
A
N
N
A
L
Q
L
L
L
GS
Y
G
K
L
P
Q
A
Q
-
T
-
V
-
N
-
S
-
D
S
L
Q
S
V
--
K
L
P
------------
A
G
L
S
S
Q
I
L
L
Q
R
P
D
I
M
E
A
E
H
A
L
M
A
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
S
G
I
S
T
A
S
S
D
L
S
S
L
--
F
--
N
AS
S
--
G
--
M
--
W
--
N
F
I
--
P
K
I
E
I
P
I
---------
F
N
A
G
R
N
Q
A
N
L
D
I
A
E
I
R
Q
Q
Q
S
V
V
N
Y
E
Q
K
I
Q
N
A
F
K
E
V
A
D
A
L
A
L
R
Q
S
L
N
D
Q
I
S
A
Q
Q
R
Y
L
A
S
L
Q
I
T
L
Q
R
A
R
A
L
Y
Q
H
G
A
V
S
Y
L
E
V
L
D
A
E
R
S
L
F
A
T
R
Q
T
L
L
D
L
N
Y
A
R
Q
V
N
E
I
S
L
Y
T
A
L
----------
6
PsiBlast_PDB
67.57
27%
2
- C6 -
-
4K7K
-
CUSC_ECOLI
A:
[32-437]
--------------------------------------------------------------------------------------
Y
---
Q
N
A
G
W
R
T
F
F
V
D
N
-
Q
V
K
T
L
I
S
E
A
L
V
N
N
R
D
L
R
M
A
T
L
K
---------
V
Q
E
A
R
A
Q
Y
R
L
T
D
A
D
R
-----------------------------------------------------------
A
---
S
-----
F
D
---
L
D
F
F
G
R
L
K
N
M
S
E
A
E
R
Q
N
Y
L
A
T
E
E
A
Q
R
A
V
H
I
L
L
V
S
N
V
A
Q
S
Y
F
N
Q
Q
L
A
Y
--
A
Q
L
Q
I
A
E
E
T
L
R
N
Y
Q
Q
S
Y
A
F
V
E
K
Q
L
L
T
G
S
S
N
V
-
L
A
L
E
Q
----
A
----
R
G
V
I
E
S
T
R
S
D
I
A
K
R
Q
G
E
L
A
Q
A
N
N
A
L
Q
L
L
L
GS
Y
G
K
L
P
Q
A
Q
-
T
-
V
-
N
-
S
-
D
S
L
Q
S
V
--
K
L
P
------------
A
G
L
S
S
Q
I
L
L
Q
R
P
D
I
M
E
A
E
H
A
L
M
A
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
S
G
I
S
T
A
S
S
D
L
S
S
L
--
F
--
N
AS
S
--
G
--
M
--
W
--
N
F
I
--
P
K
I
E
I
P
I
---------
F
N
A
G
R
N
Q
A
N
L
D
I
A
E
I
R
Q
Q
Q
S
V
V
N
Y
E
Q
K
I
Q
N
A
F
K
E
V
A
D
A
L
A
L
R
Q
S
L
N
D
Q
I
S
A
Q
Q
R
Y
L
A
S
L
Q
I
T
L
Q
R
A
R
A
L
Y
Q
H
G
A
V
S
Y
L
E
V
L
D
A
E
R
S
L
F
A
T
R
Q
T
L
L
D
L
N
Y
A
R
Q
V
N
E
I
S
L
Y
T
A
L
----------
5
PsiBlast_PDB
67.53
27%
32
- C6 -
-
3PIK
2
CUSC_ECOLI
A:
[7-437]
---------------------------------------------------------
Y
Q
R
P
A
-
M
P
V
P
Q
Q
F
S
L
--------------
Y
---
Q
N
A
G
W
R
T
F
F
V
D
N
-
Q
V
K
T
L
I
S
E
A
L
V
N
N
R
D
L
R
M
A
T
L
K
---------
V
Q
E
A
R
A
Q
Y
R
L
T
D
A
D
R
----
Y
P
Q
L
N
G
E
G
S
------
G
S
W
S
----
G
N
L
K
G
-----
N
-----
T
A
T
T
R
E
---
F
S
T
G
L
N
-
A
---
S
-----
F
D
---
L
D
F
F
G
R
L
K
N
M
S
E
A
E
R
Q
N
Y
L
A
T
E
E
A
Q
R
A
V
H
I
L
L
V
S
N
V
A
Q
S
Y
F
N
Q
Q
L
A
Y
--
A
Q
L
Q
I
A
E
E
T
L
R
N
Y
Q
Q
S
Y
A
F
V
E
K
Q
L
L
T
G
S
S
N
V
-
L
A
L
E
Q
----
A
----
R
G
V
I
E
S
T
R
S
D
I
A
K
R
Q
G
E
L
A
Q
A
N
N
A
L
Q
L
L
L
GS
Y
G
K
L
P
Q
A
Q
-
T
-
V
-
N
-
S
-
D
S
L
Q
S
V
--
K
L
P
------------
A
G
L
S
S
Q
I
L
L
Q
R
P
D
I
M
E
A
E
H
A
L
M
A
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
S
G
I
S
T
A
S
S
D
L
S
S
L
--
F
--
N
AS
S
--
G
--
M
--
W
--
N
F
I
--
P
K
I
E
I
P
I
---------
F
N
A
G
R
N
Q
A
N
L
D
I
A
E
I
R
Q
Q
Q
S
V
V
N
Y
E
Q
K
I
Q
N
A
F
K
E
V
A
D
A
L
A
L
R
Q
S
L
N
D
Q
I
S
A
Q
Q
R
Y
L
A
S
L
Q
I
T
L
Q
R
A
R
A
L
Y
Q
H
G
A
V
S
Y
L
E
V
L
D
A
E
R
S
L
F
A
T
R
Q
T
L
L
D
L
N
Y
A
R
Q
V
N
E
I
S
L
Y
T
A
L
----------
12
PsiBlast_PDB
67.06
28%
56
- C6 -
-
5AZP
17
?
A:
[8-442]
------------------------------------------------------
R
T
P
D
T
A
A
A
K
I
D
A
T
A
S
K
P
Y
D
R
S
R
--------------
F
E
S
L
W
W
K
Q
F
D
D
P
-
T
L
N
Q
L
V
E
Q
S
L
S
G
N
R
D
L
R
V
A
F
A
R
---------
L
R
A
A
R
A
L
R
D
D
V
A
N
D
R
F
P
V
V
T
S
R
A
S
A
D
I
G
------
K
G
Q
Q
----
P
G
V
T
E
-----
D
-----
R
V
N
S
E
R
---
Y
D
L
G
L
D
-
S
---
A
-----
W
E
---
L
D
L
F
G
R
I
R
R
Q
L
E
S
S
D
A
L
S
E
A
A
E
A
D
L
Q
Q
L
Q
V
S
L
I
A
E
L
V
D
A
Y
G
--
Q
L
R
G
A
Q
L
R
E
K
I
A
L
S
N
L
E
N
Q
K
E
S
R
Q
L
T
E
Q
L
R
D
A
G
V
G
A
E
-
L
D
V
L
R
----
A
----
D
A
R
L
A
A
T
A
A
S
V
P
Q
L
Q
A
E
A
E
R
A
R
H
R
I
A
T
L
L
--
G
Q
R
P
E
E
L
T
-
V
-
D
L
S
-
P
-
R
D
L
P
A
I
TK
A
L
P
------------
I
G
D
P
G
E
L
L
R
R
R
P
D
I
R
A
A
E
R
R
L
A
A
S
T
A
D
V
G
V
A
T
A
D
L
F
P
R
V
S
L
S
G
F
L
G
F
T
A
G
R
G
S
Q
I
--
G
--
S
--
S
--
A
A
R
A
--
W
--
S
V
G
--
P
S
I
S
W
A
A
---------
F
D
L
G
S
V
R
A
R
L
R
G
A
K
A
D
A
D
A
A
L
A
S
Y
E
Q
Q
V
L
L
A
L
E
E
S
A
N
A
F
S
D
Y
G
K
R
Q
E
R
L
V
S
L
V
R
Q
S
E
A
S
R
A
A
A
Q
Q
A
A
I
R
Y
R
E
G
T
T
D
F
L
V
L
L
D
A
E
R
E
Q
L
S
A
E
D
A
Q
A
Q
A
E
V
E
L
Y
R
G
I
V
A
I
Y
R
S
L
G
G
G
-------
34
HHSearch
66.90
28%
39
- C6 -
-
4MT0
-
?
A:
[12-442]
---------------------------------------------------------------
V
E
V
A
E
T
F
Q
--
N
D
T
-
S
V
---
S
S
I
R
A
---
V
D
L
G
W
H
D
Y
F
A
D
P
-
R
L
Q
K
L
I
D
I
A
L
E
R
N
T
S
L
R
T
A
V
L
N
---------
S
E
I
Y
R
K
Q
Y
M
I
--
E
R
N
----
N
L
L
P
T
L
A
A
N
------
A
N
G
S
----
R
Q
G
S
L
S----
G
-----
G
N
V
S
S
S
---
Y
N
V
G
L
G
A
A
---
S
-----
Y
E
---
L
D
L
F
G
R
V
R
S
S
S
E
A
A
L
Q
G
Y
F
A
S
V
A
N
R
D
A
A
H
L
S
L
I
A
T
V
A
K
A
Y
F
--
N
E
R
Y
A
E
E
A
M
S
L
A
Q
R
V
L
K
T
R
E
E
T
Y
N
A
V
R
I
A
V
Q
G
R
R
D
F
R
-
R
R
P
A
P
----
A
----
E
A
L
I
E
S
A
K
A
D
Y
A
H
A
A
R
S
R
E
Q
A
R
N
A
L
A
T
L
I
--
N
R
P
-
I
P
E
D
L
P
A
G
-
L
-
P
-
L
D
K
-
Q
F
--
F
V
E
--------
K
-
L
P
A
G
L
S
S
E
V
L
L
D
R
P
D
I
R
A
A
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
R
L
T
G
S
V
G
T
G
S
V
E
L
G
G
L
--
F
--
K
SG
T
--
G
V
-
W
--
A
---
F
A
--
P
S
I
T
L
P
I
---------
F
T
W
G
T
N
K
A
N
L
D
V
A
K
L
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
A
F
Q
D
V
A
N
A
L
A
A
R
E
Q
L
D
K
A
Y
D
A
L
S
K
Q
S
R
A
S
K
E
A
L
R
L
V
G
L
R
Y
K
H
G
V
S
G
A
L
D
L
L
D
A
E
R
S
S
Y
S
A
E
G
A
A
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
G
G
G
L
K
R
D
---
13
PsiBlast_PDB
65.91
26%
36
- C6 -
-
5AZS
-
OPRJ_PSEAE
A:
[7-443]
---------------------------------------------------------
Y
E
R
P
A
-
A
P
V
A
D
S
W
S
-------------------
L
--
D
W
K
S
F
I
V
D
A
-
E
L
R
R
L
V
D
M
A
L
D
N
N
R
S
L
R
Q
T
L
L
D
---------
I
E
A
A
R
A
Q
Y
R
I
Q
R
A
D
R
V
P
--
G
L
---
N
A
A
A
------
T
G
N
R
Q
R
Q
P
A
D
L
S
A
-----
G
-----
N
R
S
E
V
A
---
S
S
Y
Q
V
G
-
L
---
A
L
P
E--
Y
E
---
L
D
L
F
G
R
V
K
S
L
T
D
A
A
L
Q
Q
Y
L
A
S
E
E
A
A
R
A
A
R
I
A
L
V
A
E
V
S
Q
A
Y
L
--
S
Y
D
G
A
L
R
R
L
A
L
T
R
Q
T
L
V
S
R
E
Y
S
F
A
L
I
D
Q
R
R
A
A
G
A
A
T
A
-
L
D
Y
Q
E
----
A
L
G
L
V
E
Q
A
R
A
E
Q
E
R
N
L
R
Q
K
Q
Q
A
F
----
N
A
L
V
L
L
L
G-
S
D
D
A
A
Q
A
I
-
P
-
R
-
S
-
P
-
G
Q
R
P
K
L
---
L
Q
--------
D
-
I
A
P
G
T
P
S
E
L
I
E
R
R
P
D
I
L
A
A
E
H
R
L
R
A
R
N
A
D
I
G
A
A
R
A
A
F
F
P
R
I
S
L
T
G
S
F
G
T
S
S
A
E
M
S
G
L
--
F
--
D
--
G
--
G
--
S
--
R
--
S
W
S
F
L
P
T
L
T
L
P
I
---------
F
D
G
G
R
N
R
A
N
L
S
L
A
E
A
R
K
D
S
A
V
A
A
Y
E
G
T
I
Q
T
A
F
R
E
V
A
D
A
L
A
A
S
D
T
L
R
R
E
E
K
A
L
R
A
L
A
N
S
S
N
E
A
L
K
L
A
K
A
R
Y
E
S
G
V
D
N
H
L
R
Y
L
D
A
Q
R
S
S
F
L
N
E
I
A
F
I
D
G
S
T
Q
R
Q
I
A
L
V
D
L
F
R
A
L
G
---------
33
HHSearch
65.51
26%
37
- C6 -
-
4K7R
1
CUSC_ECOLI
A:
[1-440]
--------------------------------------------------
C
S
L
A
P
D
-
Y
Q
R
P
A
-
M
P
V
P
Q
Q
F
S
L
--------------
Y
---
Q
N
A
G
W
R
T
F
F
V
D
N
-
Q
V
K
T
L
I
S
E
A
L
V
N
N
R
D
L
R
M
A
T
L
K
---------
V
Q
E
A
R
A
Q
Y
R
L
--
T
D
A
----
D
R
Y
P
Q
L
N
G
E
------
G
S
G
S
----
W
S
G
N
L
K----
G
N----
T
A
T
T
R
E
---
F
S
T
G
L
N
-
A
---
S
-----
F
D
---
L
D
F
F
G
R
L
K
N
M
S
E
A
E
R
Q
N
Y
L
A
T
E
E
A
Q
R
A
V
H
I
L
L
V
S
N
V
A
Q
S
Y
F
--
N
Q
Q
L
A
Y
A
Q
L
Q
I
A
E
E
T
L
R
N
Y
Q
Q
S
Y
A
F
V
E
K
Q
L
L
T
G
S
S
N
V
-
L
A
L
E
Q
----
A
----
R
G
V
I
E
S
T
R
S
D
I
A
K
R
Q
G
E
L
A
Q
A
N
N
A
L
Q
L
L
L
--
G
S
Y
-
G
K
L
P
Q
A
Q
T
-
V
-
N
S
D
S
L
-
Q
----
S
V
--------
K
-
L
P
A
G
L
S
S
Q
I
L
L
Q
R
P
D
I
M
E
A
E
H
A
L
M
A
A
N
A
N
I
G
A
A
R
A
A
F
F
P
S
I
S
L
T
S
G
I
S
T
A
S
S
D
L
S
S
L
--
F
NA
S
--
S
--
G
M
-
W
--
N
---
F
I
--
P
K
I
E
I
P
I
---------
F
N
A
G
R
N
Q
A
N
L
D
I
A
E
I
R
Q
Q
Q
S
V
V
N
Y
E
Q
K
I
Q
N
A
F
K
E
V
A
D
A
L
A
L
R
Q
S
L
N
D
Q
I
S
A
Q
Q
R
Y
L
A
S
L
Q
I
T
L
Q
R
A
R
A
L
Y
Q
H
G
A
V
S
Y
L
E
V
L
D
A
E
R
S
L
F
A
T
R
Q
T
L
L
D
L
N
Y
A
R
Q
V
N
E
I
S
L
Y
T
A
L
G
G
G
-------
36
HHSearch
65.20
24%
36
- C6 -
-
5AZS
-
OPRJ_PSEAE
C:
[1-450]
--------------------------------------------------
C
S
M
A
P
T
-
Y
E
R
P
A
-
A
P
V
A
D
S
W
S
G
------------------
I
D
T
L
D
W
K
S
F
I
V
D
A
E
L
R
R
L
V
D
M
A
L
D
N
N
R
S
L
R
Q
T
L
L
D
---------
I
E
A
A
R
A
Q
Y
R
I
--
Q
R
A
----
D
R
V
P
G
L
N
A
A
------
A
T
G
N
----
R
Q
R
Q
P
ADLSA
G
-----
N
R
S
E
V
A
---
S
S
Y
Q
V
G
-
L
---
A
-----
L
P
EYE
L
D
L
F
G
R
V
K
S
L
T
D
A
A
L
Q
Q
Y
L
A
S
E
E
A
A
R
A
A
R
I
A
L
V
A
E
V
S
Q
A
Y
L
--
S
Y
D
G
A
L
R
R
L
A
L
T
R
Q
T
L
V
S
R
E
Y
S
F
A
L
I
D
Q
R
R
A
A
G
A
A
T
A
-
L
D
Y
Q
E
----
A
----
L
G
L
V
E
Q
A
R
A
E
Q
E
R
N
L
R
Q
K
Q
Q
A
F
N
A
L
V
L
L
L
--
G
S
D
-
D
A
A
Q
A
I
-
P
-
R
-
S
-
P
G
Q
R
P
K
--
L
L
Q
--------
D
-
I
A
P
G
T
P
S
E
L
I
E
R
R
P
D
I
L
A
A
E
H
R
L
R
A
R
N
A
D
I
G
A
A
R
A
A
F
F
P
R
I
S
L
T
G
S
F
G
T
S
S
A
E
M
S
G
L
--
F
--
D
GG
S
--
R
S-
W
--
S
---
F
L
--
P
T
L
T
L
P
I
---------
F
D
G
G
R
N
R
A
N
L
S
L
A
E
A
R
K
D
S
A
V
A
A
Y
E
G
T
I
Q
T
A
F
R
E
V
A
D
A
L
A
A
S
D
T
L
R
R
E
E
K
A
L
R
A
L
A
N
S
S
N
E
A
L
K
L
A
K
A
R
Y
E
S
G
V
D
N
H
L
R
Y
L
D
A
Q
R
S
S
F
L
N
E
I
A
F
I
D
G
S
T
Q
R
Q
I
A
L
V
D
L
F
R
A
L
G
G
G
W
D
E
G
R
--
38
HHSearch
64.58
27%
34
- C6 -
-
5IUY
4
?
C:
[25-446]
----------------------------------------------------------------------------------
Y
D
R
S
R
---
F
E
S
L
W
W
K
Q
F
D
D
P
-
T
L
N
Q
L
V
E
Q
S
L
S
G
N
R
D
L
R
V
A
F
A
R
---------
L
R
A
A
R
A
L
R
D
D
--
V
A
N
----
D
R
F
P
V
V
T
S
R
------
A
S
A
D
----
I
G
K
G
Q
QP---
G
VTED-
R
V
N
S
E
R
---
Y
D
L
G
L
D
-
S
---
A
-----
W
E
---
L
D
L
F
G
R
I
R
R
Q
L
E
S
S
D
A
L
S
E
A
A
E
A
D
L
Q
Q
L
Q
V
S
L
I
A
E
L
V
D
A
Y
G
--
Q
L
R
G
A
Q
L
R
E
K
I
A
L
S
N
L
E
N
Q
K
E
S
R
Q
L
T
E
Q
L
R
D
A
G
V
G
A
E
-
L
D
V
L
R
----
A
----
D
A
R
L
A
A
T
A
A
S
V
P
Q
L
Q
A
E
A
E
R
A
R
H
R
I
A
T
L
L
--
G
Q
R
-
P
E
E
L
T
V
-
D
-
L
S
P
-
R
D
L
P
A
---
I
T
K
--------
A
-
L
P
I
G
D
P
G
E
L
L
R
R
R
P
D
I
R
A
A
E
R
R
L
A
A
S
T
A
D
V
G
V
A
T
A
D
L
F
P
R
V
S
L
S
G
F
L
G
F
T
A
G
R
G
S
Q
I
GS
S
--
A
--
A
--
R
A-
W
--
S
---
V
G
--
P
S
I
S
W
A
A
---------
F
D
L
G
S
V
R
A
R
L
R
G
A
K
A
D
A
D
A
A
L
A
S
Y
E
Q
Q
V
L
L
A
L
E
E
S
A
N
A
F
S
D
Y
G
K
R
Q
E
R
L
V
S
L
V
R
Q
S
E
A
S
R
A
A
A
Q
Q
A
A
I
R
Y
R
E
G
T
T
D
F
L
V
L
L
D
A
E
R
E
Q
L
S
A
E
D
A
Q
A
Q
A
E
V
E
L
Y
R
G
I
V
A
I
Y
R
S
L
G
G
G
W
Q
P
S
---