@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VKS2: (2017-10-28 )
MSSAVVVSSENLDGQQQSSSTPASPAAEKVNLLGMSRAELEKFFEDIGEKKFRAGQVMKWIHQYFVTDFAEMTNISGKLRAKLEQICEIKAPEVVHRHYSKDGTRKWVFRVGEGSGSLVETVLIPAEDKTGSRKTLCISSQVGCALDCSFCSTGKQGFQRDLTPDEIIGQLWMANYSYMEEVPVAERERSVTNVVMMGMGEPLLNYDAVLSSMHIMLDDFAYGMSKRRVTLSTSGVVPKIDQLAKDIDVALAISLHAPNDELRNELVPINKKYPLAQLIAACQRYIAKDGNESARKHVTIEYVMLEGVNDQPEHAQQLLKLLKNLPSKINLIPFNPFPHAPYGRSSRNRIISFQKTLSDAGFVCTIRQTRGDDIDAACGQLVGQVADRTRRAEQWQKKVAQRQEILRTQG
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150...---..--------.---.160.......170.......180.......190.......200...----.----...210.......220........230......--------.---240.......-250.......260.......270.......280.......290.......300......-.310.......320....---...330.-.....-.340------------.-..------------....350.......360.......370.......380.......390.......400.......410
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MS
S
A
V
V
V
SSENLDGQQQSSSTPASP
A
A
E
K
V
N
L
LGM
S
R
A
E
L
E
K
F
F
E
D
I
G
E
KKFR
A
G
Q
V
M
K
W
I
H
Q
Y
F
V
T
D
F
A
E
M
TNI
S
G
K
L
R
A
K
L
E
Q
I
CEIK
A
P
E
V
V
H
R
H
YSKDGT
R
K
W
V
F
R
VGEGSG
S
L
V
E
T
V
L
IPAEDKTGS
R
K
T
L
C
ISSQVG
C
A
L
D
C
S
F
CSTGK---QG--------F---QRDL
T
P
D
E
I
I
G
Q
L
W
M
A
N
Y
S
Y
M
E
EVP
V
A
E
R
E
RS
V
T
N
V
V
M
MGMGEPL
L
N
----
Y
----
D
A
V
L
S
S
M
H
I
M
L
D
D
F
-AYGMSK
R
R
V
T
LSTSGVV
P
--------
K
---
I
D
Q
L
A
K
DI
D
V
-
A
L
A
I
S
L
HAP
N
D
E
L
R
N
ELVPINKKY
P
L
A
Q
L
I
A
A
C
Q
R
Y
I
AKDGNESA
R
K
H
V
T
I
E
Y
V
M
LEGV-NDQ
P
E
H
A
Q
Q
L
L
K
L
L
K
NLP---SK
I
N
L
I
P-FNPFP-HAPY------------G-RS------------SRN
R
I
I
S
F
Q
K
TLSDA
G
F
V
C
T
I
RQTRGD
D
I
D
A
A
C
G
Q
L
V
G
Q
V
A
D
R
T
R
R
A
E
Q
W
Q
K
K
V
A
Q
R
Q
E
I
L
RTQG
49
Fugue
97.09
59%
-126
- C4 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
---
D
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
C
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
--
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
--
S
N
A
N
Q
G
R
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
--------------------------------------
21
PsiBlast_CBE
96.88
58%
-121
- C4 -
-
3RF9
2
RLMN_ECOLI
B:
[17-368]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
C
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
----------
D
V
I
D
R
T
K
R
-------------------
1
PsiBlast_PDB
96.86
58%
-125
- C4 -
-
3RF9
1
RLMN_ECOLI
A:
[17-368]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
C
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
----------
D
V
I
D
R
T
K
R
-------------------
2
PsiBlast_PDB
96.63
58%
-124
- C4 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
C
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
--------------------------------------
26
HHSearch
96.24
59%
-124
- C4 -
-
3RFA
1
RLMN_ECOLI
A:
[17-349]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
-
D
--
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
C
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
A
K
I
V
G
A
A
K
--
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
--
S
N
A
N
Q
G
R
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
--------------------------------------
5
PsiBlast_PDB
96.20
58%
-108
- C4 -
-
4PL1
1
?
B:
[1-352]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
-------------------
4
PsiBlast_PDB
96.10
58%
-105
- C4 -
-
5HR6
2
RLMN_ECOLI
A:
[18-368]
-----------------------------
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
-------------------
23
PsiBlast_CBE
95.35
58%
-124
- C4 -
-
4PL1
1
?
A:
[1-332]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
---------------------------------------
22
PsiBlast_CBE
95.27
58%
-107
- C4 -
-
5HR6
2
RLMN_ECOLI
B:
[18-368]
-----------------------------
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
C
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
-------------------
3
PsiBlast_PDB
94.74
58%
-108
- C4 -
-
5HR7
2
RLMN_ECOLI
B:
[17-368]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
-
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
-------------------
24
PsiBlast_CBE
94.38
58%
-106
- C4 -
-
5HR7
2
RLMN_ECOLI
A:
[17-368]
----------------------------
K
I
N
L
L
D
L
N
R
Q
Q
M
R
E
F
F
K
D
L
G
E
K
P
F
R
A
D
Q
V
M
K
W
M
Y
H
Y
-
C
D
N
F
D
E
M
T
D
I
N
K
V
L
R
G
K
L
K
E
V
A
E
I
R
A
P
E
V
V
E
E
Q
R
S
S
D
G
T
I
K
W
A
I
A
V
G
D
---
Q
R
V
E
T
V
Y
I
P
E
D
D
----
R
A
T
L
A
V
S
S
Q
V
G
C
A
L
E
C
K
F
C
S
T
A
Q
---
Q
G
--------
F
---
N
R
N
L
R
V
S
E
I
I
G
Q
V
W
R
A
--
A
K
I
V
G
A
A
K
V
T
G
Q
R
P
I
T
N
V
V
M
M
G
M
G
E
P
L
L
N
----
L
----
N
N
V
V
P
A
M
E
I
M
L
D
D
F
-
G
F
G
L
S
K
R
R
V
T
L
S
T
S
G
V
V
P
--------
A
---
L
D
K
L
G
D
M
I
D
V
-
A
L
A
I
S
L
H
A
P
N
D
E
I
R
D
E
I
V
P
I
N
K
K
Y
N
I
E
T
F
L
A
A
V
R
R
Y
L
E
K
S
N
A
N
Q
G
R
--
V
T
I
E
Y
V
M
L
D
H
V
-
N
D
G
T
E
H
A
H
Q
L
A
E
L
L
K
D
T
P
---
C
K
I
N
L
I
P
-
W
N
P
F
P
-
G
A
P
Y
------------
G
-
R
S
------------
S
N
S
R
I
D
R
F
S
K
V
L
M
S
Y
G
F
T
T
I
V
R
K
T
R
G
D
D
I
D
A
A
-
G
Q
L
A
G
D
V
I
D
R
T
K
R
-------------------
51
Fugue
44.68
20%
-22
- C4 -
-
3C8F
3
PFLA_ECOLI
A:
[1-245]
----------------------------------------------------------------------------------------------------------------
S
V
I
G
R
I
H
S
F
E
S
C
G
T
V
D
G
P
G
I
R
F
I
T
F
F
Q
---
G
C
L
M
R
C
L
Y
C
H
N
R
D
TWD
T
H
--------
G
---
G
K
E
V
T
V
E
D
L
M
K
E
V
V
T
Y
R
H
F
M
---------
N
A
S
G
G
G
V
T
A
S
G
-
G
E
A
I
L
Q
----
A
----
E
F
V
R
D
W
F
R
A
C
K
K
E
G
-
I
H
------
T
C
L
D
T
N
G
F
V
R
RYDP----
V
---
I
D
E
L
L
E
V
T
D
L
-
V
M
L
D
-
L
K
Q
M
N
D
E
I
H
Q
N
L
V
G
V
S
-----
N
H
R
T
L
E
F
A
K
Y
L
A
N
K
N
-----
V
K
V
W
I
R
Y
V
V
V
P
G
W
-
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
NV-
E
K
I
E
L
L
P
-
Y
H
E
L
G
-
K
H
K
W
------------
V
-
A
M
GEEYKLDGVKPP
K
K
E
T
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
V
M
F
--------------------------------------------
34
HHSearch
43.72
11%
-49
- C4 -
-
4U0O
4
LIPA2_THEEB
B:
[53-273]
-------------------------------------------------------------------------------------------------------------------------------------
T
A
T
F
L
L
L
G
P
T
C
T
R
A
C
A
F
C
Q
V
E
K
---
G
H
--------
A
---
P
A
A
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
------------
L
G
L
R
Y
V
V
L
T
S
-
V
A
R
D
D
L
----
P
DQGA
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
G
T
-----
E
I
E
V
L
S
P
D
F
R
M
DRGRLSQR
D
C--
I
A
Q
I
V
-
A
A
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
------
N
P
D
I
P
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
K
D
L
R
R
V
G
C--
D
R
L
T
L
G
Q
-
Y
L
P
P
S
-
L
S
H
L
PVV---------
K
-
Y
W
------------
T
P
E
E
F
N
T
L
G
N
I
A
R
E
L
G
F
S
H
----------------------------------------------
30
HHSearch
42.27
18%
-16
* C4 *
-
3C8F
3
PFLA_ECOLI
A:
[19-245]
-------------------------------------------------------------------------------------------------------------------------------------
G
I
R
F
I
T
F
F
Q
G
C
L
M
R
C
L
Y
C
H
N
R
D
---
T
W
DTH-----
G
---
G
K
E
V
T
V
E
D
L
M
K
E
V
V
T
Y
R
H
F
M
---------
N
A
S
G
G
G
V
T
A
S
G
-
G
E
A
I
L
Q
----
A
----
E
F
V
R
D
W
F
R
A
C
K
K
-
E
-
G
I
-----
H
T
C
L
D
T
N
G
F
V
R
--------
R
YDP
V
I
D
E
L
L
E
V
T
D
-
L
V
M
L
D
L
K
Q
M
N
D
E
I
H
Q
N
L
V
G
V
----
S
N
H
R
T
L
E
F
A
K
Y
L
A
N
K
------
N
V
K
V
W
I
R
Y
V
V
V
P
G
W
-
S
D
D
D
D
S
A
H
R
L
G
E
F
T
R
D
M
G
NV-
E
K
I
E
L
L
P
-
Y
H
E
L
G
-
K
H
K
W
V
A
M
GEEYKLDGV
K
-
P
P
------------
K
K
E
T
M
E
R
V
K
G
I
L
E
Q
Y
G
H
K
V
M
F
--------------------------------------------
33
HHSearch
41.24
11%
-47
- C4 -
-
4U0P
3
LIPA2_THEEB
B:
[53-273]
-------------------------------------------------------------------------------------------------------------------------------------
T
A
T
F
L
L
L
G
P
T
C
T
R
A
C
A
F
C
Q
V
E
K
---
G
H
--------
A
---
P
A
A
V
D
P
E
E
P
T
K
I
A
A
A
V
A
T
------------
L
G
L
R
Y
V
V
L
T
S
-
V
A
R
D
D
L
----
P
DQGA
G
Q
F
V
A
T
M
A
A
I
R
Q
R
C
P
G
T
-----
E
I
E
V
L
S
P
D
F
R
M
DRGRLSQR
D
C--
I
A
Q
I
V
-
A
A
Q
P
A
C
Y
N
H
N
L
E
T
V
-
R
R
L
Q
G
P
V
R
R
---
G
A
T
Y
E
S
S
L
R
V
L
A
T
V
K
E
L
------
N
P
D
I
P
T
K
S
G
L
M
L
G
L
-
G
E
T
E
A
E
I
I
E
T
L
K
D
L
R
R
V
G
C--
D
R
L
T
L
G
Q
-
Y
L
P
P
S
-
L
S
H
L
PVV---------
K
-
Y
W
------------
T
P
E
E
F
N
T
L
G
N
I
A
R
E
L
G
F
S
H
----------------------------------------------
31
HHSearch
41.13
20%
-5
- C4 -
-
2FB2
1
MOAA_STAA8
A:
[14-202]
-------------------------------------------------------------------------------------------------------------------------------------
R
D
L
A
L
S
V
T
D
R
C
N
F
R
C
D
Y
C
M
P
K
E
---
V
F
GDDFVFLP
K
---
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
------------
L
G
V
K
K
I
R
I
T
G
-
G
E
P
L
M
R
----
R
----
D
-
L
D
V
L
I
A
K
L
N
Q
I
D
-
G
I
----
E
D
I
G
L
T
T
N
G
L
L
L
K-------
K
H--
G
Q
K
L
-
Y
D
A
G
L
R
R
I
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
N
N
R
--
N
I
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
------
G
L
N
V
K
V
N
V
V
I
Q
K
G
I
-
N
--
D
D
Q
I
I
P
M
L
E
Y
F
K
D
K
H
---
I
E
I
R
F
I
E
-
F
M
D
V
G
-
N
D
-----------------------------------------------------------------------------------------------
32
HHSearch
40.89
19%
-10
- C4 -
-
1TV8
1
MOAA_STAA8
B:
[14-201]
-------------------------------------------------------------------------------------------------------------------------------------
R
D
L
R
L
S
V
T
D
R
C
N
F
R
C
D
Y
C
M
P
K
E
---
V
F
GDDFVFLP
K
---
N
E
L
L
T
F
D
E
M
A
R
I
A
K
V
Y
A
E
------------
L
G
V
K
K
I
R
I
T
G
-
G
E
P
L
M
R
----
R
----
D
-
L
D
V
L
I
A
K
L
N
Q
I
D
-
G
I
----
E
D
I
G
L
T
T
N
G
L
L
L
KK------
H
---
G
Q
K
L
Y
D
-
A
G
L
R
R
I
N
V
S
L
D
A
I
D
D
T
L
F
Q
S
I
N
N
R
--
N
I
K
A
T
T
I
L
E
Q
I
D
Y
A
T
S
I
------
G
L
N
V
K
V
N
V
V
I
Q
K
G
I
-
N
--
D
D
Q
I
I
P
M
L
E
Y
F
K
D
K
H
---
I
E
I
R
F
I
E
-
F
M
D
V
G
-
N
------------------------------------------------------------------------------------------------
39
HHSearch
40.67
17%
-19
- C4 -
-
5FF3
4
HYDE_THEMA
A:
[53-238]
-------------------------------------------------------------------------------------------------------------------------------------
I
R
A
I
I
E
F
S
N
V
C
R
K
N
C
L
Y
C
G
L
R
R
---
D
N
--------
K
N
L
K
R
Y
R
M
T
P
E
E
I
V
E
R
A
R
L
A
V
Q
------------
F
G
A
K
T
I
V
L
Q
S
G
E
D
P
Y
-
M
----
P
----
D
V
I
S
D
I
V
K
E
I
K
K
-
M
-
G
V
-----
A
V
T
L
S
L
G
E
W
P
R
--------
E
---
Y
Y
E
K
W
K
E
A
G
A
D
R
Y
L
L
R
H
E
T
A
N
P
V
L
H
R
K
L
R
P
D
---
T
S
F
E
N
R
L
N
C
L
L
T
L
K
E
L
------
G
Y
E
T
G
A
G
--
S
M
V
G
L
P
G
Q
T
I
D
D
L
V
D
D
L
L
F
L
K
E
H
D
F--
D
M
V
G
I
G
P
-
F
I
P
H
P
-
D
T
P
L
---------------------------------------------------------------------------------------------
40
HHSearch
39.53
21%
-10
- C- -
-
3CAN
-
?
A:
[7-183]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
G
V
T
F
C
G
-
G
E
P
L
L
H
----
P
----
E
F
L
I
D
I
L
K
R
C
G
Q
-
Q
-
G
I
-----
H
R
A
V
D
T
T
L
L
A
R
--------
K
E
T
-
V
D
E
V
M
R
N
C
E
--
L
L
L
I
D
L
K
S
M
D
S
T
V
H
Q
T
F
C
D
V
----
P
N
E
L
I
L
K
N
I
R
R
V
A
E
A
------
D
F
P
Y
Y
I
R
I
P
L
I
E
G
V
-
N
A
D
E
K
N
I
K
L
S
A
E
F
L
A
S
L
P
RHP
E
I
I
N
L
L
P
-
Y
H
D
-------KM----------
Q
-
T
P
------------
S
E
E
V
Q
Q
Q
C
I
Q
I
L
T
D
Y
G
L
K
A
T
I
--------------------------------------------
36
HHSearch
38.22
11%
-33
- C4 -
-
5EXK
4
LIPA_MYCTU
A:
[91-320]
-------------------------------------------------------------------------------------------------------------------------------------
E
A
T
F
L
I
G
G
D
Q
C
T
R
R
C
D
F
C
Q
I
D
T
---
G
K
------------
P
A
E
L
D
R
D
E
P
R
R
V
A
D
S
V
R
T
------------
M
G
L
R
Y
A
T
V
T
G
-
V
A
R
D
D
L
PDGG
A
----
W
L
Y
A
A
T
V
R
A
I
K
E
L
--
N
P
---
S
T
G
V
E
L
L
I
P
D
F
N
G
E
P
------
T
---
R
L
A
E
V
F
E
S
G
P
E
V
L
A
H
N
V
E
T
V
-
P
R
I
F
K
R
I
R
P
---
A
F
T
Y
R
R
S
L
G
V
L
T
A
A
R
D
A
------
G
L
V
T
K
S
--
N
L
I
L
G
L
-
G
E
T
S
D
E
V
R
T
A
L
G
D
L
R
D
A
G
C--
D
I
V
T
I
T
Q
Y
L
R
P
S
A
R
H
H
P
V
------------
E
R
W
V
------------
K
P
E
E
F
V
Q
F
A
R
F
A
E
G
L
G
F
A
G
V
L
A
G
P
L
V
R
S
S
Y
R
A
G
R
L
Y
E
----------------------------