@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VMP7: (2017-11-09 )
MSIPQSLLEQSIQINIQQALQEDIGDGDITAMLTPEDEQATATIISREDMVLAGQPWVNALISAYDNTVQVTWLKQEGDRVAANEAFLKLAGSARSLLTVERPALNFIQTLSAVATKTAEYVQHLEGLNTKLLDTRKTLPGLRIAQKYAVTVGGGQNHRLGLFDAFLIKENHIMAAGGIAQAIAKAHQIAPGKPVEVEVETWDELNQALEAGADIVMLDNFSQQQMIDAVKHVAGRCKLEASGNITIENLREVATTGVDYISMGVLTKDVKAVDLSMRFNA
Atome Classification :
(31 SA)
---.........10--.-........20....-----.-----..------.30...-.....40........50........-60....--....70........80........90........100.......110.......120.....--..--130.......140.......150.......160.......170.......180.......-190.-.......200.......210.......220--....---...230-...---.---..---..240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
---MSI
P
Q
S
L
L
E
Q
---
S
-
I
Q
I
N
I
Q
Q
A
L
Q
E
DIG-----D-----G
D
------
I
T
A
M
LT-PEDEQA
T
A
T
I
ISRE
D
M
V
L
AG
Q
P
W
V
N
-
A
L
I
S
AY--DN
T
V
Q
V
T
W
L
KQEGDR
V
A
A
N
E
A
F
L
K
L
AGSA
R
S
L
L
T
VE
R
P
A
L
N
F
I
Q
T
L
S
A
V
A
T
K
T
A
E
Y
V
Q
H
L
E
G--LN--
T
K
L
LDTRKTLPG
L
R
I
A
Q
K
Y
A
V
T
VGGGQN
H
R
L
G
L
F
D
A
F
L
I
KEN
H
I
M
AA
G
G
I
A
Q
A
I
A
K
A
HQI-AP-G-K
P
V
E
V
E
V
E
T
W
D
E
L
N
Q
A
L
E
AGA
D
I
V
M
LDNF
S
--
Q
Q
Q
M
---
I
D
A
V
K
--
H
V
A---G---
R
C
---
K
L
EASG
N
I
T
I
E
N
L
R
E
V
A
T
T
G
V
D
Y
I
S
M
G
V
LTKD
V
K
A
V
D
L
S
M
RFNA
4
PsiBlast_PDB
84.60
52%
-131
- C6 -
-
3TQV
-
?
A:
[23-284]
----------------------
V
R
E
S
L
A
E
D
I
A
-----
T
-----
G
D
------
I
T
A
Q
L
--
A
E
D
I
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
-
E
V
I
N
Q
L
--
D
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
--
Y
K
--
T
K
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
----
G
I
A
K
A
V
T
K
A
K
K
L
-
D
S
-
N
-
K
V
V
E
V
E
V
T
N
L
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
--
G
E
D
I
---
D
I
A
V
S
--
I
A
R
---
G
---
K
V
---
A
L
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
---
2
PsiBlast_PDB
79.50
56%
-
- C- -
-
3PAJ
-
?
A:
[18-296]
----------
L
P
A
---
D
-
I
T
R
S
V
I
D
T
L
K
E
D
L
G
-----
G
TLDPA
A
D
------
I
T
A
S
L
I
-
P
A
D
R
I
S
T
A
T
I
I
T
R
E
A
G
V
F
C
G
Q
L
W
A
D
-
E
V
F
K
Q
L
--
G
G
Q
V
S
I
E
W
H
V
Q
D
G
D
T
L
T
P
N
Q
T
L
C
T
L
T
G
P
A
R
I
L
L
T
G
E
R
N
A
M
N
F
I
Q
T
L
S
G
C
A
T
A
T
A
R
Y
V
Q
E
L
K
G
--
T
Q
--
C
R
L
L
D
T
R
K
T
I
P
G
L
R
S
A
L
K
Y
A
V
A
C
G
G
G
Y
N
H
R
I
G
V
F
D
A
Y
L
I
K
E
N
H
I
I
A
C
G
G
I
R
Q
A
I
S
T
A
K
Q
L
-
N
P
-
G
-
K
P
V
E
V
E
T
E
T
L
A
E
L
E
E
A
I
S
A
G
A
D
I
I
M
L
D
N
F
S
--
L
E
M
M
---
R
E
A
V
K
--
I
N
A
---
G
---
R
A
---
A
L
E
N
S
G
N
I
T
L
D
N
L
K
E
C
A
E
T
G
V
D
Y
I
S
V
G
A
L
T
K
H
L
K
A
L
D
L
S
M
R
F
K
S
3
PsiBlast_PDB
78.88
50%
-125
- C6 -
-
3GNN
-
?
A:
[25-296]
----------
F
D
A
---
A
-
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-----
S
-----
G
-----------
L
V
-
P
D
G
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
-
A
V
V
R
A
V
--
D
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
--
T
R
--
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
A
L
-
N
----
V
P
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
--
L
D
M
M
---
R
D
A
V
R
--
V
T
E
---
G
---
R
A
---
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
I
--
118
HHSearch
78.49
56%
-
- C- -
-
3PAJ
-
?
A:
[13-295]
-----
Y
L
K
Q
Q
L
P
A
---
D
-
I
T
R
S
V
I
D
T
L
K
E
D
L
G
GTLDP
A
-----
A
D
------
I
T
A
S
-
L
I
P
A
D
R
I
S
T
A
T
I
I
T
R
E
A
G
V
F
C
G
Q
L
W
A
D
-
E
V
F
K
Q
L
--
G
G
Q
V
S
I
E
W
H
V
Q
D
G
D
T
L
T
P
N
Q
T
L
C
T
L
T
G
P
A
R
I
L
L
T
G
E
R
N
A
M
N
F
I
Q
T
L
S
G
C
A
T
A
T
A
R
Y
V
Q
E
L
K
G
--
T
Q
--
C
R
L
L
D
T
R
K
T
I
P
G
L
R
S
A
L
K
Y
A
V
A
C
G
G
G
Y
N
H
R
I
G
V
F
D
A
Y
L
I
K
E
N
H
I
I
A
C
G
G
I
R
Q
A
I
S
T
A
K
-
Q
-
L
N
-
P
G
K
P
V
E
V
E
T
E
T
L
A
E
L
E
E
A
I
S
A
G
A
D
I
I
M
L
D
N
F
S
--
L
E
M
M
---
R
E
A
V
K
--
I
N
A
---
G
---
R
A
---
A
L
E
N
S
G
N
I
T
L
D
N
L
K
E
C
A
E
T
G
V
D
Y
I
S
V
G
A
L
T
K
H
L
K
A
L
D
L
S
M
R
F
K
-
125
HHSearch
76.88
51%
-55
- C6 -
-
3TQV
-
?
B:
[12-286]
-------
N
K
V
P
N
D
---
I
-
V
T
R
L
V
R
E
S
L
A
E
D
I
A
-----
T
-----
G
D
------
I
T
A
Q
L
A
--
E
D
I
D
T
T
A
F
C
I
T
R
E
E
M
I
L
C
G
Q
D
F
A
N
-
E
V
I
N
Q
L
--
D
K
N
I
Q
I
T
W
L
Y
S
D
A
Q
K
V
P
A
N
A
R
I
F
E
L
K
G
N
V
R
S
I
L
T
A
E
R
T
I
L
N
F
I
Q
M
L
S
G
T
A
T
V
T
N
K
L
V
K
L
I
S
Q
--
Y
K
--
T
K
L
L
D
T
R
K
T
I
P
G
F
R
L
A
Q
K
Y
A
V
R
C
G
G
G
F
N
H
R
I
G
L
F
D
A
Y
L
I
K
E
N
H
I
R
S
A
G
G
I
A
K
A
V
T
K
A
K
-
K
L
D
S
-
N
-
K
V
V
E
V
E
V
T
N
L
D
E
L
N
Q
A
I
A
A
K
A
D
I
V
M
L
D
N
F
S
--
G
E
D
I
---
D
I
A
V
S
--
I
A
R
---
G
---
K
V
---
A
L
E
V
S
G
N
I
D
R
N
S
I
V
A
I
A
K
T
G
V
D
F
I
S
V
G
A
I
T
K
H
I
K
A
I
D
L
S
L
Q
V
Q
-
120
HHSearch
74.11
50%
-119
- C6 -
-
3GNN
-
?
B:
[21-295]
------
Y
G
A
A
F
D
A
---
A
-
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-----
S
-----
G
D
------
Q
---------
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
-
A
V
V
R
A
V
--
D
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
--
T
R
--
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
-----------------------------------------
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
--
L
D
M
M
---
R
D
A
V
R
--
V
T
E
---
G
---
R
A
---
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
---
21
PsiBlast_CBE
71.86
57%
11
- C6 -
-
1QAP
1
NADC_SALTY
B:
[13-295]
--------
A
L
L
E
R
INL
D
-
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-----
G
EVDAG
N
D
------
I
T
A
Q
L
L
-
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
A
--
G
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
--
T
Q
--
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
-
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
--
T
D
Q
M
---
R
E
A
V
K
--
R
V
N
---
G
---
Q
A
---
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
--
127
HHSearch
71.82
58%
20
- C6 -
-
1QAP
2
NADC_SALTY
A:
[16-296]
--------
E
R
I
N
L
---
D
-
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
GEVDA
G
-----
N
D
------
I
T
A
Q
L
L
-
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
-
E
V
F
I
Q
L
A-
G
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
--
T
Q
--
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
-
W
L
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
--
T
D
Q
M
---
R
E
A
V
K
--
R
V
N
---
G
---
Q
A
---
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-
1
PsiBlast_PDB
71.00
57%
12
- C6 -
-
1QAP
2
NADC_SALTY
A:
[13-295]
--------
A
L
L
E
R
I
N
L
D
-
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-----
G
EVDAG
N
D
------
I
T
A
Q
L
L
-
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
E
V
F
I
Q
L
A
--
G
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
--
T
Q
--
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
-
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
--
T
D
Q
M
---
R
E
A
V
K
--
R
V
N
---
G
---
Q
A
---
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
--
121
HHSearch
69.80
50%
-41
- C6 -
-
3GNN
-
?
A:
[21-297]
------
Y
G
A
A
F
D
A
---
A
-
I
A
R
N
V
A
D
A
L
A
E
D
V
G
-----
S
-----
G
-----------
L
V
-
P
D
G
A
P
R
R
A
R
V
I
V
R
E
D
A
V
L
C
G
V
P
W
F
D
-
A
V
V
R
A
V
--
D
P
S
I
E
V
D
W
R
H
R
E
G
D
R
M
S
A
D
S
T
V
C
E
L
R
G
P
A
R
A
L
L
T
A
E
R
N
A
L
N
F
L
Q
L
L
S
G
V
A
S
A
T
R
Q
Y
V
D
R
I
A
D
--
T
R
--
A
R
I
L
D
T
R
K
T
L
P
G
L
R
L
A
Q
K
Y
A
V
R
V
G
G
G
A
N
Q
-------------------
G
V
G
E
A
L
D
A
A
F
-
A
L
N
----
V
P
V
Q
I
E
V
E
T
L
D
Q
L
R
T
A
L
A
H
G
A
R
S
V
L
L
D
N
F
T
--
L
D
M
M
---
R
D
A
V
R
--
V
T
E
---
G
---
R
A
---
V
L
E
V
S
G
G
V
N
F
D
T
V
R
A
I
A
E
T
G
V
D
R
I
S
I
G
A
L
T
K
D
V
R
A
T
D
Y
S
M
R
I
V
-
108
Fugue
69.57
55%
12
- C6 -
-
1QAP
2
NADC_SALTY
A:
[8-296]
DD
R
R
D
A
L
L
E
R
I
N
L
---
D
-
I
P
A
A
V
A
Q
A
L
R
E
D
L
G
-----
G
-----
E
V
DAGNDI
T
A
Q
L
-
L
-
P
A
D
T
Q
A
H
A
T
V
I
T
R
E
D
G
V
F
C
G
K
R
W
V
E
-
E
V
F
I
Q
L
AG-
D
D
V
R
L
T
W
H
V
D
D
G
D
A
I
H
A
N
Q
T
V
F
E
L
Q
G
P
A
R
V
L
L
T
G
E
R
T
A
L
N
F
V
Q
T
L
S
G
V
A
S
E
V
R
R
Y
V
G
L
L
A
G
--
T
Q
--
T
Q
L
L
D
T
R
K
T
L
P
G
L
R
T
A
L
K
Y
A
V
L
C
G
G
G
A
N
H
R
L
G
L
T
D
A
F
L
I
K
E
N
H
I
I
A
S
G
S
V
R
Q
A
V
E
K
A
F
W
L
-
H
P
-
D
-
V
P
V
E
V
E
V
E
N
L
D
E
L
D
D
A
L
K
A
G
A
D
I
I
M
L
D
N
F
N
--
T
D
Q
M
---
R
E
A
V
K
--
R
V
N
---------GQA
R
L
E
V
S
G
N
V
T
A
E
T
L
R
E
F
A
E
T
G
V
D
F
I
S
V
G
A
L
T
K
H
V
R
A
L
D
L
S
M
R
F
C
-
131
HHSearch
66.39
35%
-58
- C6 -
-
2B7N
1
NADC_HELPY
B:
[2-273]
----------------
E
-
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
T
----
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
-
K
N
L
P
-
F
T
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
--
V
L
E
T
---
K
E
I
A
A
--
Y
R
D
AHY
P
---
F
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
M
A
-
65
PsiBlast_CBE
66.39
35%
-63
- C6 -
-
2B7N
1
NADC_HELPY
B:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
64
PsiBlast_CBE
66.30
35%
-61
- C6 -
-
2B7N
1
NADC_HELPY
C:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
14
PsiBlast_PDB
66.26
35%
-60
- C6 -
-
2B7N
1
NADC_HELPY
A:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
---
I
A
A
Y
R
D
A
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
62
PsiBlast_CBE
65.87
35%
-65
- C6 -
-
2B7P
1
NADC_HELPY
C:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
15
PsiBlast_PDB
65.52
35%
-57
- C6 -
-
2B7P
1
NADC_HELPY
A:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
---
I
A
A
Y
R
D
A
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
128
HHSearch
65.48
46%
10
- C6 -
-
1X1O
-
?
C:
[10-284]
----------
W
Q
G
---
G
-
L
E
E
A
L
R
A
W
L
R
E
D
L
G
-----
Q
-----
G
D
------
L
T
S
L
L
V
V
P
E
D
L
E
G
E
A
V
I
L
A
K
E
G
G
V
L
A
G
L
W
V
A
E
-
R
V
F
A
L
A
--
D
P
R
T
A
F
T
P
L
V
A
E
G
A
R
V
A
E
G
T
E
V
A
R
V
R
G
P
L
R
G
I
L
A
G
E
R
L
A
L
N
L
L
Q
R
L
S
G
I
A
T
L
T
R
A
Y
V
E
A
L
A
G
--
T
K
--
A
Q
I
L
D
T
R
K
T
T
P
G
L
R
A
L
E
K
Y
A
V
R
V
G
G
G
R
N
H
R
Y
G
L
F
D
G
I
L
L
K
E
N
H
V
R
A
A
G
G
V
G
E
A
V
R
R
A
K
-
A
R
A
P
-
H
Y
L
K
V
E
V
E
V
R
S
L
E
E
L
E
E
A
L
E
A
G
A
D
L
I
L
L
D
N
F
P
--
L
E
A
L
---
R
E
A
V
R
--
R
V
G
---
G
---
R
V
---
P
L
E
A
S
G
N
M
T
L
E
R
A
K
A
A
A
E
A
G
V
D
Y
V
S
V
G
A
L
T
H
S
A
K
A
L
D
L
S
L
L
V
V
-
60
PsiBlast_CBE
65.26
35%
-57
- C6 -
-
2B7Q
1
NADC_HELPY
C:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
63
PsiBlast_CBE
64.48
35%
-60
- C6 -
-
2B7P
1
NADC_HELPY
B:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
61
PsiBlast_CBE
63.00
35%
-56
- C6 -
-
2B7Q
1
NADC_HELPY
B:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
VL
E
T
K
E
---
I
A
A
Y
R
DA
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
102
PsiBlast_CBE
62.82
34%
-43
- C6 -
-
4I9A
1
?
A:
[23-287]
--------------------------
L
R
E
D
C
P
-----
G
-----
L
N
------
P
V
A
L
V
T
--
G
A
A
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
-
A
I
F
A
Q
V
--
N
--
C
Q
V
S
W
F
L
P
E
G
S
K
L
V
P
V
A
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
--
T
G
WA
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
-
A
N
F
A
-
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
--
P
E
E
L
H
P
T
A
A
A
L
K
--
A
Q
F
---
P
---
T
V
---
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
F
A
16
PsiBlast_PDB
62.65
35%
-57
- C6 -
-
2B7Q
1
NADC_HELPY
A:
[3-271]
------------------
I
R
T
F
L
E
R
A
L
K
E
D
L
G
-----
H
-----
G
D
------
L
F
E
R
V
L
-
E
K
D
F
K
A
T
A
F
V
R
A
K
Q
E
G
V
F
S
G
E
K
Y
A
L
-
E
L
L
E
M
----
T
G
I
E
C
V
Q
T
I
K
D
K
E
R
F
K
P
K
D
A
L
M
E
I
R
G
D
F
S
M
L
L
K
V
E
R
T
L
L
N
L
L
Q
H
S
S
G
I
A
T
L
T
S
R
F
V
E
A
L
N
S
--
H
K
--
V
R
L
L
D
T
R
K
T
R
P
L
L
R
I
F
E
K
Y
S
V
L
N
G
G
A
S
N
H
R
L
G
L
D
D
A
L
M
L
K
D
T
H
L
R
H
V
K
D
L
K
S
F
L
T
H
A
R
K
N
-
L
P
F
T
-
A
K
I
E
I
E
C
E
S
F
E
E
A
K
N
A
M
N
A
G
A
D
I
V
M
C
D
N
L
S
V
L
E
T
K
E
---
I
A
A
Y
R
D
A
H
Y
P
---
F
----
V
---
L
L
E
A
S
G
N
I
S
L
E
S
I
N
A
Y
A
K
S
G
V
D
A
I
S
V
G
A
L
I
H
Q
A
T
F
I
D
M
H
M
K
---
101
PsiBlast_CBE
62.61
34%
-39
- C6 -
-
4I9A
1
?
B:
[23-287]
--------------------------
L
R
E
D
C
P
-----
G
-----
L
N
------
P
V
A
L
V
T
--
G
A
A
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
-
A
I
F
A
Q
V
--
N
--
C
Q
V
S
W
F
L
P
E
G
S
K
L
V
P
V
A
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
--
T
G
WA
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
R
A
-
A
N
F
A
-
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
--
P
E
E
L
HPT
A
A
A
L
K
--
A
Q
F
---
P
---
T
V
---
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
F
A
123
HHSearch
58.91
35%
21
- C6 -
-
3L0G
2
?
C:
[22-295]
----------
M
K
I
---
S
-
F
S
E
I
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
-
K
N
L
K
-
N
-
E
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I
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I
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N
I
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V
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L
S
N
N
V
D
M
I
L
L
D
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M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
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S
---
V
L
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V
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C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
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Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
-
124
HHSearch
57.77
35%
27
- C6 -
-
3L0G
2
?
B:
[24-295]
------------
I
---
S
-
F
S
E
I
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
L
I
N
E
-
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
-
K
N
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
D
I
E
-
58
PsiBlast_CBE
56.95
36%
20
- C6 -
-
3L0G
2
?
C:
[30-292]
----------------------
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
-
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
-
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
----
59
PsiBlast_CBE
56.91
36%
23
- C6 -
-
3L0G
2
?
B:
[30-292]
----------------------
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
-
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
-
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
----
13
PsiBlast_PDB
56.83
36%
22
- C6 -
-
3L0G
2
?
A:
[30-292]
----------------------
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
-
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
-
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
----
57
PsiBlast_CBE
56.14
36%
20
- C6 -
-
3L0G
2
?
D:
[30-292]
----------------------
I
H
N
A
L
K
E
D
L
G
-----
D
K----
G
D
------
I
T
T
N
S
I
-
L
I
N
E
K
V
N
F
A
I
N
T
R
E
N
L
V
V
C
G
I
P
I
L
E
-
E
V
F
N
M
N
--
K
E
H
V
K
Y
E
I
H
K
K
D
G
D
I
T
G
K
N
S
T
L
V
S
G
E
A
L
A
I
Y
L
L
P
I
E
R
V
I
L
N
F
I
Q
H
A
S
G
I
A
S
I
T
R
Q
F
V
D
E
V
S
G
--
T
K
--
V
K
I
R
S
T
R
K
T
T
P
G
L
R
M
L
D
K
Y
S
V
C
I
G
G
G
E
S
Y
R
D
N
L
C
D
G
V
L
I
K
D
N
H
I
A
S
C
G
S
I
T
L
A
I
Q
R
L
R
K
N
-
L
K
-
N
-
E
Y
I
A
I
E
C
D
N
I
S
Q
V
E
E
S
L
S
N
N
V
D
M
I
L
L
D
N
M
S
--
I
S
E
I
---
K
K
A
V
D
--
I
V
N
---
G
---
K
S
---
V
L
E
V
S
G
C
V
N
I
R
N
V
R
N
I
A
L
T
G
V
D
Y
I
S
I
G
C
I
T
N
S
F
Q
N
K
D
I
G
L
----
130
HHSearch
55.12
33%
24
- C6 -
-
4I9A
1
?
B:
[8-287]
--------
L
L
L
P
P
---
A
T
L
A
T
L
A
D
S
W
L
R
E
D
C
------------
P
G
------
L
N
P
V
A
L
V
T
G
A
A
P
S
Q
A
V
L
W
A
K
S
P
G
I
L
A
G
R
P
F
F
D
-
A
I
F
A
Q
V
----
N
C
Q
V
S
W
F
L
P
E
G
S
K
L
V
P
V
A
K
V
A
E
V
R
G
P
A
H
C
L
L
L
G
E
R
V
A
L
N
M
L
A
R
C
S
G
V
A
S
A
A
A
T
A
V
E
T
A
R
G
TG
W
A
--
G
H
V
A
G
T
R
K
T
T
P
G
F
R
L
V
E
K
Y
G
L
L
V
G
G
A
T
S
H
R
Y
D
L
G
G
L
V
M
V
K
D
N
H
V
V
A
A
G
G
V
K
Q
A
V
Q
G
A
R
-
R
A
A
N
-
F
A
L
K
V
E
V
E
C
S
S
L
Q
E
A
L
E
A
A
E
A
G
A
D
L
V
L
L
D
N
F
R
--
P
E
E
L
---
H
P
T
A
A
--
A
L
K
---
A
QFP
T
V
---
G
V
E
A
S
G
G
V
T
L
D
N
L
P
Q
F
C
G
P
H
I
D
V
I
S
L
G
M
L
T
Q
A
A
P
A
L
D
F
S
L
K
L
F
A