@TOME V2.3
(Mar 2018)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VQN9: (2017-11-28 )
MTVAMSIMISTEEIQAKVKELGEQINSHYANSDKELVLIGLLRGSVIFMADLCRTITKPHELDFMTVSSYGGGTTSSRDVKILKDLDGEIRGKDVLVVEDIIDSGNTLSKVVEMLQTREPNSIQLCTLVCKPSRREIDLEVKFLGFEVEDKFIVGYGLDYDQKYRHLPFIGEIGL
Atome Classification :
(46 SA)
.........10........20........----30..-----......40........50.......---.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
T
V
A
M
S
I
M
I
S
T
E
E
I
Q
A
K
V
K
E
L
G
E
Q
I
N
S
HY----ANSD-----
K
E
L
V
L
I
G
LLRG
S
V
I
F
M
A
D
L
C
R
T
ITK---PHE
L
D
F
M
T
V
SSYGGGTTSSR
D
V
K
I
L
K
DLDGEIRG
K
D
V
L
V
V
E
D
I
IDSG
N
T
L
S
K
V
V
E
M
L
QTREPN
S
I
Q
L
C
T
L
V
CKPSR
R
E
I
D
L
E
V
K
F
L
G
F
E
V
ED
K
F
I
V
G
YGL
D
Y
D
Q
KYRHLPFIGEIGL
7
PsiBlast_PDB
94.41
60%
-165
- C1 -
-
5KNX
1
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
Y
G
S
----
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
124
HHSearch
93.74
61%
-156
- C1 -
-
5KNX
1
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
Y
G
S
G
M
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
22
PsiBlast_CBE
93.36
60%
-156
- C1 -
-
5KNX
1
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
Y
G
S
G
M
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
24
PsiBlast_CBE
92.39
60%
-168
- C1 -
-
5KNU
1
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
Y
-----
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
26
PsiBlast_CBE
91.97
60%
-168
- C1 -
-
5KNS
2
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
------
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
10
PsiBlast_PDB
91.22
60%
-164
- C1 -
-
1GRV
-
HPRT_ECOLI
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
---------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
2
PsiBlast_PDB
91.07
60%
-162
- C1 -
-
5KNR
1
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
Y
G
-----
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
25
PsiBlast_CBE
90.84
60%
-168
- C1 -
-
5KNT
2
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
------
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
29
PsiBlast_CBE
90.41
60%
-165
- C1 -
-
1G9T
1
HPRT_ECOLI
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
3
PsiBlast_PDB
90.27
60%
-165
- C1 -
-
5KNS
2
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
5
PsiBlast_PDB
89.87
60%
-159
- C1 -
-
5KNU
2
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
6
PsiBlast_PDB
89.30
60%
-160
- C1 -
-
5KNV
1
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
30
PsiBlast_CBE
89.05
60%
-165
- C1 -
-
1G9S
1
HPRT_ECOLI
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
27
PsiBlast_CBE
88.98
60%
-158
- C1 -
-
5KNR
1
?
B:
[6-179]
-
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
-----
S
T
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
9
PsiBlast_PDB
88.97
60%
-171
- C1 -
-
1G9T
1
HPRT_ECOLI
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
---------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
4
PsiBlast_PDB
88.65
60%
-164
- C1 -
-
5KNT
1
?
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
--------
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
8
PsiBlast_PDB
88.03
60%
-164
- C1 -
-
1G9S
1
HPRT_ECOLI
A:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
--------
R
D
L
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
1
PsiBlast_PDB
87.95
61%
-167
- C1 -
-
1J7J
-
HPRT_SALTY
A:
[3-174]
--
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
E
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
P
H
E
V
D
F
M
T
A
S
---------
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
G
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
D
V
P
V
E
F
V
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
V
G
K
V
V
-
23
PsiBlast_CBE
87.70
60%
-165
- C1 -
-
5KNV
1
?
B:
[5-179]
M
K
H
T
V
E
V
M
I
P
E
A
E
I
K
A
R
I
A
E
L
G
R
Q
I
T
E
R
Y
----
K
D
S
G
-----
S
D
M
V
L
V
G
L
L
R
G
S
F
M
F
M
A
D
L
C
R
E
V
Q
V
---
S
H
E
V
D
F
M
T
A
S
S
-------
T
R
D
V
K
I
L
K
D
L
D
E
D
I
R
G
K
D
V
L
I
V
E
D
I
I
D
S
G
N
T
L
S
K
V
R
E
I
L
S
L
R
E
P
K
S
L
A
I
C
T
L
L
D
K
P
S
R
R
E
V
N
V
P
V
E
F
I
G
F
S
I
P
D
E
F
V
V
G
Y
G
I
D
Y
A
Q
R
Y
R
H
L
P
Y
I
G
K
V
I
L
12
PsiBlast_PDB
86.73
58%
-179
- C1 -
-
4LYY
-
?
A:
[29-194]
------
V
M
I
T
A
E
E
I
D
Q
K
L
D
I
L
A
E
Q
I
N
A
H
Y
----
A
D
S
D
-----
R
-
L
L
M
V
G
L
L
K
G
S
V
V
F
M
A
D
L
C
R
R
I
K
G
---
H
V
E
I
D
F
M
S
V
S
--------
S
R
D
V
K
I
L
K
D
V
Q
S
E
I
Q
G
R
D
V
L
I
V
E
D
L
I
D
S
G
N
T
L
N
K
V
R
D
M
L
L
L
R
E
P
K
S
L
A
L
C
T
L
L
D
K
P
E
R
R
E
V
D
V
P
V
D
F
I
G
F
T
I
P
D
E
F
I
V
G
Y
G
I
D
Y
A
E
Q
Y
R
N
L
P
Y
I
A
K
V
--
14
PsiBlast_PDB
83.93
56%
-160
- C1 -
-
1YFZ
1
?
A:
[35-197]
------
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
----
E
G
-------
K
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
D
L
---
P
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
----
31
PsiBlast_CBE
82.38
56%
-164
- C1 -
-
1YFZ
1
?
B:
[35-197]
------
I
L
I
T
E
E
Q
L
K
A
K
V
K
E
L
G
E
M
I
T
R
D
Y
----
E
G
-------
K
D
L
V
L
I
G
V
L
K
G
A
I
M
F
M
S
G
L
S
R
A
I
D
L
---
P
L
S
I
D
F
L
A
V
S
S
Y
G
S
S
T
K
S
S
G
I
V
K
I
I
K
D
H
D
I
D
I
E
G
K
D
V
L
I
V
E
D
I
I
D
S
G
L
T
L
A
Y
L
R
E
T
L
L
G
R
K
P
R
S
L
K
I
C
T
I
L
D
K
P
E
R
R
E
A
D
V
K
V
D
Y
C
G
F
K
I
P
D
K
F
V
V
G
Y
G
L
D
Y
A
E
K
Y
R
N
L
P
F
I
G
----
62
PsiBlast_CBE
81.30
46%
-185
- C1 -
-
3O7M
1
?
C:
[12-175]
-------
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
----
E
G
-------
E
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
K
N
---
D
V
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
--
64
PsiBlast_CBE
80.73
46%
-182
- C1 -
-
3O7M
2
?
A:
[12-175]
-------
L
I
S
E
E
Q
L
Q
E
K
V
K
E
L
A
L
Q
I
E
R
D
F
----
E
G
-------
E
E
I
V
V
I
A
V
L
K
G
S
F
V
F
A
A
D
L
I
R
H
I
K
N
---
D
V
T
I
D
F
I
S
A
S
S
Y
G
-------
K
V
K
L
L
K
D
I
D
V
N
I
T
G
K
N
V
I
V
V
E
D
I
I
D
S
G
L
T
L
H
F
L
K
D
H
F
F
M
H
K
P
K
A
L
K
F
C
T
L
L
D
K
P
E
R
R
K
V
D
L
T
A
E
Y
V
G
F
Q
I
P
D
E
F
I
V
G
Y
G
I
D
C
A
E
K
Y
R
N
L
P
F
I
A
S
V
--
16
PsiBlast_PDB
79.93
49%
-153
- C1 -
-
3H83
2
?
A:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
125
HHSearch
78.96
47%
-149
- C1 -
-
3HVU
1
?
D:
[29-199]
--
D
I
E
K
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
-------
T
V
P
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
V
L
K
P
35
PsiBlast_CBE
78.54
49%
-153
- C1 -
-
3KB8
1
?
B:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
18
PsiBlast_PDB
77.27
49%
-154
- C1 -
-
3KB8
2
?
A:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
41
PsiBlast_CBE
77.14
49%
-147
- C1 -
-
3H83
1
?
B:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
17
PsiBlast_PDB
76.77
49%
-147
- C1 -
-
3HVU
1
?
A:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
56
PsiBlast_CBE
76.49
47%
-177
- C1 -
-
4RHT
2
HPRT_MYCTU
D:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
-------------
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
G
S
----
S
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
---
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
38
PsiBlast_CBE
76.26
49%
-149
- C1 -
-
3HVU
1
?
B:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
37
PsiBlast_CBE
76.04
49%
-146
- C1 -
-
3HVU
1
?
C:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
36
PsiBlast_CBE
75.24
49%
-144
- C1 -
-
3HVU
1
?
D:
[33-195]
------
V
L
I
S
E
E
Q
I
Q
E
K
V
L
E
L
G
A
I
I
A
E
D
Y
----
K
N
T
V
-----
P
--
L
A
I
G
V
L
K
G
A
M
P
F
M
A
D
L
L
K
R
T
D
T
---
Y
L
E
M
D
F
M
A
V
S
S
Y
G
H
S
T
V
S
T
G
E
V
K
I
L
K
D
L
D
T
S
V
E
G
R
D
I
L
I
V
E
D
I
I
D
S
G
L
T
L
S
Y
L
V
D
L
F
K
Y
R
K
A
K
S
V
K
I
V
T
L
L
D
K
P
T
G
R
K
V
D
L
K
A
D
Y
V
G
F
T
V
P
H
E
F
V
V
G
Y
G
L
D
Y
K
E
Q
Y
R
N
L
P
Y
V
G
----
57
PsiBlast_CBE
73.05
47%
-82
- C1 -
-
4RHT
2
HPRT_MYCTU
C:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R----
T
T
G
-----
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
-
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
54
PsiBlast_CBE
70.75
47%
-33
- C1 -
-
4RHU
1
HPRT_MYCTU
B:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
RELS
A
T
T
G
-----
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
--
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
59
PsiBlast_CBE
70.54
47%
-75
- C1 -
-
4RHT
2
HPRT_MYCTU
A:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
R------
G
-----
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
G
------
G
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
53
PsiBlast_CBE
69.37
47%
-47
- C1 -
-
4RHU
1
HPRT_MYCTU
C:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
RELS
A
T
T
G
-----
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
G
-------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
58
PsiBlast_CBE
66.25
47%
-69
- C1 -
-
4RHT
2
HPRT_MYCTU
B:
[24-195]
-----
S
V
L
L
T
A
E
Q
I
Q
A
R
I
A
E
L
G
E
Q
I
G
N
D
Y
RE-----------
Q
D
L
L
L
I
T
V
L
K
G
A
V
L
F
V
T
D
L
A
R
A
I
P
V
---
P
T
Q
F
E
F
M
A
V
S
S
Y
--------
V
V
R
I
L
K
D
L
D
R
D
I
H
G
R
D
V
L
I
V
E
D
V
V
D
S
G
L
T
L
S
W
L
S
R
N
L
T
S
R
N
P
R
S
L
R
V
C
T
L
L
R
K
P
D
A
V
H
A
N
V
E
I
A
Y
V
G
F
D
I
P
N
D
F
V
V
G
Y
G
L
D
Y
D
E
R
Y
R
D
L
S
Y
I
G
T
L
--
73
PsiBlast_CBE
65.57
38%
-33
- C1 -
-
1P18
2
?
B:
[8-179]
---
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
----
K
G
K
G
LRPYV
N
P
L
V
L
I
S
V
L
R
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
FNV
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
--------
81
PsiBlast_CBE
64.79
38%
-32
- C1 -
-
1TC2
2
?
B:
[8-179]
---
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
----
K
G
K
G
LRPYV
N
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
F
N
V
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
D
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
--------
87
PsiBlast_CBE
64.35
37%
-30
- C1 -
-
1I0L
2
?
B:
[8-179]
---
A
E
K
I
L
F
T
E
E
E
I
R
T
R
I
K
E
V
A
K
R
I
A
D
D
Y
----
K
G
K
G
LRPYV
N
P
L
V
L
I
S
V
L
K
G
S
F
M
F
T
A
D
L
C
R
A
L
C
D
FNV
P
V
R
M
E
F
I
C
V
S
S
Y
G
E
G
L
T
S
S
G
Q
V
R
M
L
L
D
T
R
H
S
I
E
G
H
H
V
L
I
V
E
D
I
V
N
T
A
L
T
L
N
Y
L
Y
H
M
Y
F
T
R
R
P
A
S
L
K
T
V
V
L
L
D
K
R
E
G
R
R
V
P
F
S
A
D
Y
V
V
A
N
I
P
N
A
F
V
I
G
Y
G
L
D
Y
D
D
T
Y
R
E
L
--------
102
PsiBlast_CBE
59.71
36%
-13
- C1 -
-
5JV5
1
HPRT_TRYBB
A:
[16-187]
---
A
T
S
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
----
S
N
C
N
LKPLE
N
P
L
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
G
D
F
G
V
P
T
R
V
E
F
L
R
--------------------
L
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
--------
95
PsiBlast_CBE
58.98
36%
-17
- C1 -
-
5KAP
1
HPRT_TRYBB
B:
[16-187]
---
A
T
S
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
----
S
N
C
N
LKPLE
N
P
L
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
G
D
F
G
V
P
T
R
V
E
F
L
R
---------------------
C
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
--------
101
PsiBlast_CBE
58.18
36%
-10
- C1 -
-
5JV5
1
HPRT_TRYBB
B:
[16-187]
---
A
T
S
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
----
S
N
C
N
LKPLE
N
P
L
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
G
D
F
G
V
P
T
R
V
E
F
L
-----------------------
D
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
--------
96
PsiBlast_CBE
56.35
36%
-17
- C1 -
-
5KAP
1
HPRT_TRYBB
A:
[17-187]
----
T
S
V
L
F
T
E
A
E
L
H
T
R
M
R
G
V
A
Q
R
I
A
D
D
Y
----
S
N
C
N
LKPLE
N
P
L
V
I
V
S
V
L
K
G
S
F
V
F
T
A
D
M
V
R
I
L
G
D
F
G
V
P
T
R
V
E
F
L
R
-----------------------
I
R
G
K
H
V
L
V
L
E
D
I
L
D
T
A
L
T
L
R
E
V
V
D
S
L
K
K
S
E
P
A
S
I
K
T
L
V
A
I
D
K
P
G
G
R
K
I
P
F
T
A
E
Y
V
V
A
D
V
P
N
V
F
V
V
G
Y
G
L
D
Y
D
Q
S
Y
R
E
V
--------