@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : B0VSD7: (2017-12-07 )
MFMTESRLTHLKQLEAESIHIIREVAAEFENPVMLYSIGKDSAVMLHLALKAFYPAKLPFPLLHVDTGWKFKDMIAFRDNMAKTHGFDLIVHQNKEGREAGINPFDHGSSKYTDIMKTQALKQALDKYQFDAAFGGARRDEEKSRAKERVYSFRDSKHRWDPKNQRPELWNLYNGKVNKGESIRVFPLSNWTELDIWQYIYLENIQIVPLYFSAVRPVVERSGTLIMVDDERMRLKEGEVPQMKSVRFRTLGCYPLTGAVESEADTLPEIIQEMLLATSSERQGRMIDHDEAGSMEKKKQEGYF
Atome Classification :
(20 SA)
------------------------.........10-........20-...-.----....----30---.........40........--50....------------------.-...60.....---...70-.-........80......----..90..-----...--.---.-----------.-----100--..---...---.--...110--.......120....-.-..-130.......140.-......150.......160.......170...-....180....-...190.......200.......210.......220...------....230.......240.......250.......260.......270----.......280.......290........300..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------MFM
T
E
S
R
L
T
H
L
-
K
Q
L
E
A
E
S
I
H
I
-
I
R
E
-
V
----
A
A
E
F----E----N
P
V
M
L
Y
S
IGKDS
A
V
M
L
H
L
A
--
L
K
A
FYP------------------A-KLPF
P
L
L
H
VD---TGW
K
--
F
-
K
D
M
I
A
F
R
DNMAKTH
G
F
----
D
L
I
V
HQ-----NKE--G---R-----------E-----A----GI---NPF---D--HGS
S
K
Y
--
T
D
I
M
K
T
Q
A
L
K
Q
A
L
D
-
K
-YQ-FDAAFGGARR
D
E
E
K
-
S
R
A
K
E
R
V
Y
S
FRDSKHRWDPKNQRP
E
L
W
N
LYNG-KVNKG
E
S
I
R
V
F
-PLSNWTEL
D
I
W
Q
Y
I
Y
L
EN
I
Q
I
V
P
L
Y
F
S
A
V
R
P
V
V
ERSG
T
L
------
I
M
VDDERMRLKEGEVPQMK
S
V
R
F
R
T
L
GCYPLTGAVES
E
A
D
T
L
P
E
I
I
Q
----
E
M
L
L
ATSSERQGRMIDHD-EAG
S
M
E
K
K
K
QEGYF
10
HHSearch
91.35
77%
-105
- C6 -
-
1ZUN
1
CYSD_PSESM
A:
[22-231]
----------------------------
V
D
K
L
T
H
L
-
K
Q
L
E
A
E
S
I
H
I
-
I
R
E
-
V
----
A
A
E
F
----
D
----
N
P
V
M
L
Y
S
I
G
K
D
S
A
V
M
L
H
L
A
--
R
K
A
F
F
P
------------------
G
-
K
L
P
F
P
V
M
H
V
D
---
T
R
W
K
--
F
-
Q
E
M
Y
R
F
R
D
Q
M
V
E
E
M
G
L
----
D
L
I
T
H
I
-----
N
-----------------------------------------------
S
A
K
H
--
T
D
I
M
K
T
E
G
L
K
Q
A
L
D
-
K
-
H
G
-
F
D
A
A
F
G
G
A
R
R
D
E
E
K
-
S
R
A
K
E
R
V
Y
S
F
R
D
S
K
H
R
W
D
P
K
N
Q
R
P
E
L
W
N
V
Y
N
G
-
N
V
N
K
G
E
S
I
R
V
F
-
P
L
S
N
W
T
E
L
D
I
W
Q
Y
I
Y
L
E
G
I
P
I
V
P
L
Y
F
A
A
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
90.77
75%
-106
- C6 -
-
1ZUN
1
CYSD_PSESM
A:
[24-231]
------------------------------
K
L
T
H
L
-
K
Q
L
E
A
E
S
I
H
I
-
I
R
E
-
V
----
A
A
E
F
----
D
----
N
P
V
M
L
Y
S
I
G
K
D
S
A
V
M
L
H
L
A
--
R
K
A
F
F
P
------------------
G
-
K
L
P
F
P
V
M
H
V
D
---
T
R
W
K
--
F
-
Q
E
M
Y
R
F
R
D
Q
M
V
E
E
M
G
L
----
D
L
I
T
H
I
-----
N
-----------------------------------------------
S
A
K
H
--
T
D
I
M
K
T
E
G
L
K
Q
A
L
D
-
K
-
H
G
-
F
D
A
A
F
G
G
A
R
R
D
E
E
K
-
S
R
A
K
E
R
V
Y
S
F
R
D
S
K
H
R
W
D
P
K
N
Q
R
P
E
L
W
N
V
Y
N
G
-
N
V
N
K
G
E
S
I
R
V
F
-
P
L
S
N
W
T
E
L
D
I
W
Q
Y
I
Y
L
E
G
I
P
I
V
P
L
Y
F
A
A
-----------------------------------------------------------------------------------------------------
11
HHSearch
63.18
25%
-24
- C6 -
-
4BWV
1
?
A:
[44-260]
------------------------------
R
D
A
R
L
-
Q
H
L
E
A
Q
A
L
E
T
-
L
Q
K
-
T
----
V
E
N
F
----
E
----
K
P
A
F
P
C
A
L
I
A
G
D
V
V
I
L
D
L
L
--
H
R
I
G
A
F
------------------
S
-
D
N
K
V
K
I
I
F
I
D
---
T
F
H
L
--
F
-
P
E
T
Y
K
F
L
S
E
V
E
E
R
Y
G
F
----
K
A
H
V
F
H
-----
A
A
D
VN
N
K
E
A
Y
-----------
D
-----
A
K
F--
G
S
---
D
L
F
---
I
--
T
D
I
E
E
Y
--
D
R
I
C
K
V
E
P
F
S
R
A
L
K
-
T
-
L
E
-
V
D
A
M
I
N
G
R
R
R
D
H
G
A
-
E
R
A
H
L
E
V
F
E
---------------------------
E
G
K
M
V
K
V
Q
-
P
L
A
Y
W
E
F
R
D
C
W
D
Y
L
T
K
Y
S
L
P
Y
H
P
L
H
D
Q
---------------------------------------
G
F
P
S
I
G
D
V
Q
S
T
I
P
V
P
R
E
-
K
W
------------
F
-
E
Y
A
G
E
R
S
G
R
--------------------
2
PsiBlast_PDB
60.58
23%
-37
- C6 -
-
4BWV
1
?
A:
[42-229]
----------------------------
Q
A
R
D
A
R
L
-
Q
H
L
E
A
Q
A
L
E
T
-
L
Q
K
-
T
----
V
E
N
F
----
E
----
K
P
A
F
P
C
A
L
I
A
G
D
V
V
I
L
D
L
L
H
R
I
G
A
F
S
D
------------------
N
-
K
V
K
--
I
I
F
I
D
---
T
F
H
L
--
F
-
P
E
T
Y
K
F
L
S
E
V
E
E
R
Y
G
F
----
K
A
H
V
F
H
AADVN
N
K
E
--
A
---
Y
-----------
D
-----
A
K
F--
G
S
---
D
L
F
---
I
--
T
D
I
E
E
Y
--
D
R
I
C
K
V
E
P
F
S
R
A
L
K
-
T
-
L
E
-
V
D
A
M
I
N
G
R
R
R
D
H
G
A
-
E
R
A
H
L
E
V
F
---------------------------
E
E
G
K
M
V
K
V
Q
-
P
L
A
Y
W
E
F
R
D
C
W
D
Y
L
T
K
Y
S
L
P
Y
H
P
L
H
--------------------------------------------------------------------------------------------------------
12
HHSearch
57.28
20%
7
- C6 -
-
2OQ2
1
MET16_YEAST
C:
[29-256]
-----------------------------------------
T
P
Q
E
I
-
I
A
W
-
S
----
I
V
T
F
----
P
----
H
L
F
Q
T
T
A
F
G
L
T
G
L
V
T
I
D
M
L
--
S
K
L
S
E
K
--------------------
Y
Y
M
P
E
L
L
F
I
D
---
T
L
H
H
--
F
-
P
Q
T
L
T
L
K
N
E
I
E
K
K
Y
Y
Q
PKNQ
T
I
H
V
Y
K
-----
P
D
G
--
C
ES-
E
-----------
A
DFASK
Y
----
G
D
---
F
L
W
---
E
--
K
D
D
D
K
Y
--
D
Y
L
A
K
V
E
P
A
H
R
A
Y
K
-
E
-
L
H
-
I
S
A
V
F
T
G
R
R
K
S
Q
G
S
-
A
R
S
Q
L
S
I
I
E
I
D
------------------------
E
L
N
G
I
L
K
I
N
-
P
L
I
N
W
T
F
E
Q
V
K
Q
Y
I
D
A
N
N
V
P
Y
N
E
L
L
D
L
---------------------------------------
G
Y
R
S
I
G
D
Y
H
S
T
Q
P
V
K
E
G
-------------------
E
D
E
R
A
G
R
W
K
G
K
A
K
T
E
C
G
I
H
E
A
S
R
F
A
Q
F
4
PsiBlast_PDB
55.42
24%
-51
- C6 -
-
1SUR
-
CYSH_ECOLI
A:
[48-204]
-----------------------------------------------------------------------
V
L
S
S
S
F
G
I
Q
A
A
V
S
L
H
L
V
--
N
Q
I
-----------------------
R
P
D
I
P
V
I
L
T
D
---
T
G
Y
L
--
F
-
P
E
T
Y
R
F
I
D
E
L
T
D
K
L
K
L
----
N
L
K
V
Y
R
-----
A
T
E
--
S
---
A
A
W
Q
E
A
R
YGKLW
E
-----
Q
----
G
V
------------
E
G
I
E
K
Y
--
N
D
I
N
K
V
E
P
M
N
R
A
L
K
-
E
-
L
N
-
A
Q
T
W
F
A
G
L
R
R
E
Q
S
G
-
S
R
A
------------------------
N
L
P
V
L
-
A
I
Q
R
G
-
V
F
K
V
L
-
P
I
I
D
W
D
N
R
T
I
Y
Q
Y
L
Q
K
H
G
L
K
Y
H
P
L
W
--------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
52.14
24%
-55
- C6 -
-
2O8V
-
CYSH_ECOLI
A:
[49-219]
-----------------------------------------------------------------------
V
L
S
S
S
F
G
I
Q
A
A
V
S
L
H
L
V
--
N
Q
I
-----------------------
R
P
D
I
P
V
I
L
T
D
---
T
G
Y
L
--
F
-
P
E
T
Y
R
F
I
D
E
L
T
D
K
L
K
L
----
N
L
K
V
Y
R
-----
A
T
E
--
S
---
A
A
W
Q
E
A
R
Y
GKLW
E
-----
Q
----
G
V
------------
E
G
I
E
K
Y
--
N
D
I
N
K
V
E
P
M
N
R
A
L
K
-
E
-
L
N
-
A
Q
T
W
F
A
G
L
R
R
E
Q
S
G
-
S
R
A
------------------------
N
L
P
V
L
-
A
I
Q
R
G
-
V
F
K
V
L
-
P
I
I
D
W
D
N
R
T
I
Y
Q
Y
L
Q
K
H
G
L
K
Y
H
P
L
W
--------------------------------------------------------------------------------------------------------
18
HHSearch
52.07
25%
12
- C6 -
-
1SUR
-
CYSH_ECOLI
A:
[31-206]
-----------------------------------------
D
A
E
G
R
-
V
A
W
-
A
----
L
D
N
L
P---
G
----
E
Y
V
L
S
S
S
F
G
I
Q
A
A
V
S
L
H
L
V
--
N
Q
I
R
-----------------------
P
D
I
P
V
I
L
T
D
---
T
G
Y
L
--
F
-
P
E
T
Y
R
F
I
D
E
L
T
D
K
L
K
L
----
N
L
K
V
Y
R
-----
A
T
E
--
S
---
A
-----------
A
-----
W
Q
E
A
R
Y
G
---
K
L
W
EQG
V
--
E
G
I
E
K
Y
--
N
D
I
N
K
V
E
P
M
N
R
A
L
K
-
E
-
L
N
-
A
Q
T
W
F
A
G
L
R
R
E
Q
S
G
-
S
R
A
N
L
P
V
L
A
--------------------------
I
Q
R
G
V
F
K
V
L
-
P
I
I
D
W
D
N
R
T
I
Y
Q
Y
L
Q
K
H
G
L
K
Y
H
P
L
W
D
E
------------------------------------------------------------------------------------------------------
16
HHSearch
51.85
22%
19
- C6 -
-
2GOY
2
CYSH_PSEAE
D:
[41-249]
-----------------------------------------
S
P
Q
D
I
-
L
K
A
-
A
----
F
E
H
F
----
G
D---
E
L
W
I
S
F
S
G
A
E
D
V
-
V
L
V
D
M
A
--
W
K
L
N
-----------------------
R
N
V
K
V
F
S
L
D
---
T
G
R
L
--
H
-
P
E
T
Y
R
F
I
D
Q
V
R
E
H
Y
G
I
----
A
I
D
V
L
S
-----
P
D
P
--
R
---
L
-----------
L
EPLV-
K
EK--
G
L
---
F
S
F
Y--
R
--
D
G
H
G
E
C
--
C
G
I
R
K
I
E
P
L
K
R
K
L
A
----
G
-
V
R
A
W
A
T
G
Q
R
R
D
Q
S
P
G
T
R
S
Q
V
A
V
L
E
I
D
G
----
A
------------
F
---
S
T
P
E
K
P
L
Y
K
F
N
-
P
L
S
S
M
T
S
E
E
V
W
G
Y
I
R
M
L
E
L
P
Y
N
S
L
H
E
R
---------------------------------------
G
Y
I
S
I
G
C
E
P
C
T
R
P
V
L
P
N
-------------------
Q
H
E
R
E
G
R
W
W
W
E
----------------
15
HHSearch
51.76
21%
-22
- C6 -
-
3FWK
1
?
A:
[30-235]
-----------------------------
S
I
I
A
Q
T
-
Q
R
A
I
N
T
T
K
S
I
L
I
N
E
-
T
----
F
P
K
W
SPLN
G
----
E
I
S
F
S
Y
N
G
G
K
D
C
Q
V
L
L
L
L
Y
--
L
S
C
L
W
E
Y
Y
IVK
L
------------------
P
T
V
F
I
D
---
H
D
D
T
--
F
-
K
T
L
E
N
F
I
E
E
T
S
L
R
Y
S
L
----
S
L
Y
E
S
D
-----
R
------------------------------------------------
D
K
C
--
E
T
M
A
E
--
A
F
E
T
F
L
Q
-
V
F
P
E
-
T
K
A
I
V
I
G
I
R
H
T
D
P
F
-
G
E
H
L
K
P
I
Q
K
---
T
D
--------------------
A
N
W
P
D
F
Y
R
L
Q
-
P
L
L
H
W
N
L
A
N
I
W
S
F
L
L
Y
S
N
E
P
I
C
E
L
Y
R
Y
---------------------------------------
G
F
T
S
L
G
N
V
E
E
T
L
P
--------------------------------------------------
17
HHSearch
51.36
21%
-16
- C6 -
-
2WSI
1
FAD1_YEAST
A:
[25-239]
---------------------------------
Q
I
-
I
A
S
T
Q
E
A
I
R
L
-
T
R
K
Y
L
LSEI
F
V
R
W
SPLN
G
----
E
I
S
F
S
Y
N
G
G
K
D
C
Q
V
L
L
L
L
Y
--
L
S
C
L
W
E
Y
F
F
I
K
A
Q
N
SF--------
P
-
M
Q
R
L
P
T
V
F
I
D
---
Q
E
E
T
--
F
-
P
T
L
E
N
F
V
L
E
T
S
E
R
Y
C
L
----
S
L
Y
E
S
Q
-----
R
------------------------------------------
V
--
N
M
A
D
A
F
--
R
D
F
I
K
I
Y
P
----------
E
-
T
E
A
I
V
I
G
I
R
H
T
D
P
F
-
G
E
A
L
K
P
I
Q
R
---
T
----
D
----------------
S
N
W
P
D
F
M
R
L
Q
-
P
L
L
H
W
D
L
T
N
I
W
S
F
L
L
Y
S
N
E
P
I
C
G
L
Y
G
K
---------------------------------------
G
F
T
S
I
G
G
I
N
N
S
L
P
N
-------------------------------------------------
14
HHSearch
51.25
21%
4
- C6 -
-
3G5A
2
?
B:
[30-235]
-----------------------------
S
I
I
A
Q
T
-
Q
R
A
I
N
T
T
K
S
I
L
I
N
E
-
T
----
F
P
K
W
SPLN
G
----
E
I
S
F
S
Y
N
G
G
K
D
C
Q
V
L
L
L
L
Y
--
L
S
C
L
W
E
Y
Y
I
V
KLSQSQFDG
K
F
H
R
F
P
-
L
T
K
L
P
T
V
F
I
D
---
H
D
D
T
--
F
-
K
T
L
E
N
F
I
E
E
T
S
L
R
Y
S
L
----
S
L
Y
E
S
D
-----
R
------------------------------------------------
D
K
C
--
E
T
M
A
E
--
A
F
E
T
F
L
Q
-
V
F
P
E
-
T
K
A
I
V
I
G
I
R
H
T
D
P
F
-
G
E
H
L
K
P
I
Q
K
---
T
D
--------------------
A
N
W
P
D
F
Y
R
L
Q
-
P
L
L
H
W
N
L
A
N
I
W
S
F
L
L
Y
S
N
E
P
I
C
E
L
Y
R
Y
---------------------------------------
G
F
T
S
L
G
N
V
E
E
T
L
P
--------------------------------------------------
22
HHSearch
50.20
13%
-62
- C6 -
-
2DPL
-
GUAAB_PYRHO
A:
[4-186]
------------------------------------
G
R
F
V
E
E
K
V
R
E
-
I
R
E
-
T
----
V
G
D
-----
S
----
K
A
I
I
A
L
S
G
G
V
D
S
S
T
A
A
V
L
A
--
H
K
A
I
G
----------------------
D
R
L
H
A
V
F
V
N
---
T
G
F
L
R-
K
-
G
E
P
E
F
V
V
K
T
F
R
D
E
F
G
M
----
N
L
H
Y
V
D
-----
A
Q
D
--
R
---
F
-----------
F
-----
S
----
A
L
KGV
T
D
P
---
E
--
E
K
R
K
I
I
--
G
R
-
V
F
I
E
V
F
E
E
V
A
K
-
K
-
I
G
-
A
E
Y
L
I
Q
G
T
I
A
P
-----------------------------------------
L
N
L
K
L
I
E
-
P
L
R
D
L
Y
K
D
E
V
R
E
L
A
K
F
L
G
L
P
E
K
I
Y
N
R
M
------------------------------------------------------------------------------------------------------
24
HHSearch
48.50
16%
-80
- C6 -
-
2YWB
-
GUAA_THET8
C:
[193-391]
------------------------------------
E
H
V
L
E
E
L
L
R
E
-
V
R
E
-
R
----
A
G
-
K
----
D
----
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
--
A
K
A
G
-----------------------
V
D
H
L
A
V
F
V
D
---
H
G
L
L
--
R
-
L
G
E
R
E
E
V
E
G
A
L
R
A
L
G
V
----
N
L
L
V
V
D
-----
A
K
E
--
R
---
F
-----------
L
-----
K
A
L
K-
G
V
---
E
D
P
---
E
--
E
K
R
K
I
I
--
G
R
E
F
-
V
A
A
F
S
Q
V
A
R
-
E
-
R
G
P
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
-
E
S
A
-----------------------------------
E
F
E
L
L
E
-
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
------------------------------------------------------------------------------------------------------
25
HHSearch
47.89
16%
-65
- C6 -
-
2YWC
1
GUAA_THET8
A:
[193-391]
------------------------------------
E
H
V
L
E
E
L
L
R
E
-
V
R
E
-
R
----
A
G
-
K
----
D
----
R
V
L
L
A
V
S
G
G
V
D
S
S
T
L
A
L
L
L
--
A
K
A
G
-----------------------
V
D
H
L
A
V
F
V
D
---
H
G
L
L
--
R
-
L
G
E
R
E
E
V
E
G
A
L
R
A
L
G
V
----
N
L
L
V
V
D
-----
A
K
E
--
R
---
F
-----------
L
-----
K
A
L
K-
G
V
---
E
D
P
---
E
--
E
K
R
K
I
I
--
G
R
E
F
-
V
A
A
F
S
Q
V
A
R
-
E
-
R
G
P
F
R
F
L
A
Q
G
T
L
Y
P
D
V
I
-
E
----------------------
G
-
G
-------
L
P
E
D
L
E
F
E
L
L
E
-
P
F
R
L
L
F
K
D
E
V
R
E
L
A
L
L
L
G
L
P
D
T
L
R
L
R
H
------------------------------------------------------------------------------------------------------
20
HHSearch
47.62
14%
-63
- C6 -
-
5TW7
-
GUAA_NEIG2
C:
[208-417]
----------------------------------
M
-
P
N
Y
I
E
E
A
V
A
K
-
I
R
E
-
Q
----
V
G
S
-----
D
----
E
V
I
L
G
L
S
G
G
V
D
S
S
V
A
A
A
L
I
--
H
R
A
I
G
----------------------
D
Q
L
T
C
V
F
V
D
---
H
G
L
L
--
R
L
N
E
G
K
M
V
M
D
M
F
A
R
N
L
G
V
----
K
V
I
H
V
D
-----
A
E
G
--
Q
---
F
-----------
M
-----
A
K
L
A-
G
V
---
T
D
P
---
E
--
K
K
R
K
I
I
--
G
A
E
F
I
E
V
F
D
A
E
E
K
K
-
L
-
T
N
-
A
K
W
L
A
Q
G
T
I
Y
P
D
V
I
-
E
-------------------------------------
K
L
K
L
L
E
-
P
L
R
D
L
F
K
D
E
V
R
E
L
G
V
A
L
G
L
P
R
E
M
V
Y
R
H
---------------------------------------
P
F
P
G
P
G
L
G
V
R
I
L
G
E
-------------------------------------------------
32
Fugue
46.83
18%
27
- C6 -
-
3FWK
1
?
A:
[1-308]
GAMVMR
L
G
D
A
A
E
L
C
Y
N
L
T
S
S
Y
L
Q
I
A
A
E
S
D
S
I
I
A
Q
T
Q
R
A
I
N
T
T
K
S
I
L
-
I
N
E
-
T
----
F
P
K
W
----
S
PLNG
E
I
S
F
S
Y
N
G
G
K
D
C
Q
V
L
L
L
L
Y
--
L
S
C
L
W
E
------------------
Y
Y
I
V
K
L
P
T
V
F
I
D
---
H
D
D
T
--
F
-
K
T
L
E
N
F
I
E
E
T
S
L
R
Y
S
L
----
S
L
Y
E
S
D
-----
R
D
K
--
C
---
E
-----------
T
------------------------------------
M
A
E
A
F
E
T
F
L
Q
V
F
-
P
E
-
T
K
A
I
V
I
G
I
R
H
T
D
P
F
-
G
E
H
L
K
---
P
I
Q
K
T
D
A
N
W
------
P
D
F
--------------
Y
R
L
Q
-
P
L
L
H
W
N
L
A
N
I
W
S
F
L
L
Y
S
N
E
P
I
C
E
L
Y
R
Y
G
F
T
S
L
G
N
V
E
E
T
L
PNPHLR
K
D
K
N
S
T
P
L
K
L
N
F
E
W
E
I
E
N
R
Y
K
H
N
E
V
T
K
A
E
P
I
P
I
A
D
E
D
L
V
K
I
E
N
L
H
E
D
Y
Y
P
G
W
Y
L
V
D
D
K
L
E
R
A
G
R
I
K
K
K
----------------
35
Fugue
46.50
16%
21
- C6 -
-
3VRH
1
?
A:
[1-309]
------MKCKFCSREAYIKIHYP
K
M
Y
L
C
E
E
H
F
K
E
Y
-
F
E
R
K
V
S
R
T
I
E
-
R
Y
K
-
L
----
L
T
K
D
----
E
----
R
I
L
V
A
V
S
G
G
K
D
S
A
V
T
A
Y
V
L
--
K
K
L
-----------------------
G
Y
N
I
E
C
L
H
I
N
LGI
S
G
Y
S
--
E
-
K
S
E
E
Y
A
K
K
Q
C
K
L
I
-
G
A
----
P
L
H
I
V
R
-----
I
K
E
--
I
---
L
-----------
G
-----
Y
----
G
I
---
G
E
V
KT-
R
--
R
P
P
C
S
Y
--
C
G
L
T
K
R
Y
I
M
N
K
F
A
Y
-
D
-
N
G
-
F
D
A
I
A
T
G
H
N
L
D
D
E
A
-
S
F
L
L
N
N
I
L
H
W
N
-----------
T
E
Y
L
A
K
G
G
P
I
-
L
P
Q
Q
G
K
F
I
K
K
V
K
P
L
Y
E
V
T
E
R
E
V
V
A
Y
A
L
A
V
G
L
E
----
Y
I
V
E
E
C
P
Y
T
T
L
D
M
K
G
------
V
L
N
E
L
E
E
K
R
--
P
G
T
K
F
N
F
V
R
G
Y
L
K
K
K
K
L
F
E
P
K
E
C
K
I
C
R
M
P
S
S
G
D
I
C
A
----
F
C
K
F
W
G
L
K
K
E
I
N
F
K
V
S
S
T
-
D
E
E
P
F
G
--------
31
HHSearch
46.16
19%
14
* C6 *
-
5GHA
2
?
B:
[46-223]
----------------------------------------------------------
P
G
----
E
----
R
V
L
V
A
V
S
G
G
K
D
S
L
A
L
W
D
V
L
--
S
R
L
G
-----------------------
Y
Q
A
V
G
L
H
I
E
---
L
G
I
G
E
Y
S
-
K
R
S
L
E
V
T
Q
A
F
A
R
E
R
G
L
----
E
L
L
V
V
D
-----
L
K
E
--
A
---
Y
-----------
G
-----
F
----
G
V
---
P
E
L
---
A
R
L
S
G
R
V
A
C
S
A
C
G
L
S
K
R
Y
I
I
N
Q
V
A
V
-
E
-
E
G
-
F
R
V
V
A
T
G
H
N
L
D
D
E
A
-
A
V
L
F
G
N
L
L
N
P
Q
------------------
G
P
V
L
P
E
K
P
G
L
A
A
R
V
K
-
P
F
Y
R
F
S
E
R
E
V
L
S
Y
T
L
L
R
G
I
R
Y
L
H
E
E
--------------------------------------------------------------------------------------------------------
19
HHSearch
44.87
14%
-63
- C6 -
-
5TW7
-
GUAA_NEIG2
D:
[208-415]
----------------------------------
M
-
P
N
Y
I
E
E
A
V
A
K
-
I
R
E
-
Q
----
V
G
S
-----
D
----
E
V
I
L
G
L
S
G
G
V
D
S
S
V
A
A
A
L
I
--
H
R
A
I
G
----------------------
D
Q
L
T
C
V
F
V
D
---
H
G
L
L
--
R
L
N
E
G
K
M
V
M
D
M
F
A
R
N
L
G
V
----
K
V
I
H
V
D
-----
A
E
G
--
Q
---
F
-----------
M
-----
A
K
L
A-
G
V
---
T
D
P
---
E
--
K
K
R
K
I
I
--
G
A
E
F
I
E
V
F
D
A
E
E
K
K
-
L
-
T
N
-
A
K
W
L
A
Q
G
T
I
Y
P
D
V
I
----------------------------------------
L
K
L
L
E
-
P
L
R
D
L
F
K
D
E
V
R
E
L
G
V
A
L
G
L
P
R
E
M
V
Y
R
H
---------------------------------------
P
F
P
G
P
G
L
G
V
R
I
L
G
E
-------------------------------------------------