@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZ18: (2017-12-15 )
MGGMTMSQFDQSITLPSGVQLKNRLMLSPMTTQLSFFNGVITEDEITYYKQRSKGLGAVITGAANVQDIGKGWPGELSIAHDEMIPRLSELAKAIQGEGAKAIIQIFHGGRMTSRATLSGEQPVSASAVAAKRPDAETPRAMSEEEIVETIQAFGKATRRAIESGFDGIELHGANTYLIQQFFSPHSNRREDQWGGSLENRYRFIEELLTTVFSAVEQYAKKPFIVGYRFSPEEYETPGIRFEDTIWLLERLRESKLDYLHVSLNMYDRIARSDKYNDKSILEVVHNTIQGKIPLVGVGGIRNREDVEQVLKYAELAAIGQQMIVDPDWAEKLLENREDEFVTKPFEEAYKELYLPSPLYNFLKARYQ
Atome Classification :
(22 SA)
.........10........20........30.-.......40...-.....50..-.-.-....60........70........80........90........100.......110......------------.------120.......130---------.--------------......140........150.......160.......170.......180.......190....-...200.......210.......220.......230...-..--.-.240-.----.---.----.....250..-----.------...--------.260.---.....-.-270..----.--..-....280-.....---...290--.--......300.......310-.--.-......320.......330.......340-........350.......360......-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MGG
M
T
M
S
Q
FDQSITLPSG
V
Q
L
K
N
R
L
MLSP
M
T
T
-
Q
L
S
F
FNGVITE
D
-
E
I
T
Y
Y
K
Q
RS-K-G-L
G
A
V
I
TGAA
N
V
Q
D
I
GKGWPGE
L
S
I
A
H
D
E
M
I
P
R
L
S
E
L
A
K
A
I
QGE
G
A
K
A
I
I
Q
I
FHGGRMT
S
R
ATL------------S------GEQPVSASAVAAK---------R--------------PDAETPR-AM
S
E
E
E
I
V
E
T
I
Q
A
F
G
K
A
T
R
R
A
I
E
SGFD
G
I
E
LHGA
N
T
Y
L
I
Q
Q
F
FSPHSNRR
E
D
QWGG-
S
L
E
N
R
Y
R
F
I
E
E
L
L
T
T
V
F
S
A
V
E
Q
Y
AKK
P
F
I
V
G
Y
RF
S
P
E
EY-ET--P-GIR--
F
----
E
---
D
----
T
I
W
L
L
E
R
L
R
E
-----S------KL
D
--------
Y
L
H
V
S
---
L
N
M
Y
D
-
R
-
I
--AR----S--DK-YN
D
K
S
I
--
L
E
V
V
H
---
N
TIQGK--I--
P
L
V
GVGGIR
N
R
E
D
V
E
Q
V
L
--
K
--
Y
-
A
E
L
A
A
I
G
Q
QMIVD
P
D
W
A
E
K
L
L
ENREDEF--VTK
P
F
E
E
A
Y
K
ELYL
P
S
P
L
Y
N
F
L
K
A
RYQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
82.33
32%
-34
- C2 -
-
3L5A
3
?
A:
[21-391]
--
M
Y
R
Y
K
P
L
L
Q
S
I
H
L
P
N
G
I
K
I
S
N
R
F
V
L
S
P
M
T
V
-
N
A
S
T
K
E
G
Y
I
T
K
A
-
D
L
A
Y
A
A
R
R
S
-
N
-
S
-
A
G
M
Q
V
T
G
A
A
Y
I
E
P
Y
G
K
L
F
E
Y
G
F
N
I
D
H
D
A
C
I
P
G
L
T
N
M
A
S
T
M
K
Q
H
G
S
L
A
I
I
Q
L
A
H
A
G
R
F
S
N
Q
A
I
L
------------
N
------
F
G
K
V
Y
G
P
S
P
M
T
L
H
---------
S
--------------
P
I
E
H
V
V
I
-
A
M
S
H
E
K
I
N
S
I
I
Q
Q
Y
R
D
A
T
L
R
A
I
K
A
G
F
D
G
V
E
I
S
I
A
Q
R
L
L
I
Q
T
F
F
S
T
F
S
N
R
R
T
D
H
Y
G
A
D
S
L
K
N
R
A
R
L
C
L
E
V
M
R
A
V
Q
E
V
I
D
K
E
A
P
D
N
F
I
L
G
F
R
A
T
P
E
E
T
-
R
G
SD
L
-
G
Y
T
--
I
----
D
---
E
----
F
N
Q
L
I
D
W
V
M
D
V
----
S
------
N
I
Q
--------
Y
L
A
I
A
---
S
W
G
R
H
-
I
Y
Q
NT
S
R
----
T
--
P
G
D
H
F
G
R
P
V
--
N
Q
I
V
Y
---
E
H
L
A
G
R
--
I
--
P
L
I
A
S
G
G
I
N
S
P
E
S
A
L
D
A
L
--
Q
--
H
-
A
D
M
V
G
M
S
S
P
F
V
T
E
P
D
F
V
H
K
L
A
E
Q
R
P
H
D
I
--
N
L
E
F
S
M
A
D
L
E
D
L
A
I
P
H
A
A
F
K
D
I
V
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.44
34%
-36
- C2 -
-
3L5A
3
?
A:
[29-363]
----------
Q
S
I
H
L
P
N
G
I
K
I
S
N
R
F
V
L
S
P
M
T
V
-
N
A
S
T
K
E
G
Y
I
T
K
A
-
D
L
A
Y
A
A
R
R
S
-
N
-
S
-
A
G
M
Q
V
T
G
A
A
Y
I
E
P
Y
G
K
L
F
E
Y
G
F
N
I
D
H
D
A
C
I
P
G
L
T
N
M
A
S
T
M
K
Q
H
G
S
L
A
I
I
Q
L
A
H
A
G
R
F
S
N
Q
A
I
L
------------
N
------
F
G
K
V
Y
G
P
S
P
M
T
L
H
---------
S
--------------
P
I
E
H
V
V
I
-
A
M
S
H
E
K
I
N
S
I
I
Q
Q
Y
R
D
A
T
L
R
A
I
K
A
G
F
D
G
V
E
I
S
I
A
Q
R
L
L
I
Q
T
F
F
S
T
F
S
N
R
R
T
D
H
Y
G
A
D
S
L
K
N
R
A
R
L
C
L
E
V
M
R
A
V
Q
E
V
I
D
K
E
A
P
D
N
F
I
L
G
F
R
A
T
P
E
---
E
T
--
R
-
G
S
D
--
L
----
G
---
Y
----
T
I
D
E
F
N
Q
L
I
D
W
V
M
D
V
S
------
N
I
Q
--------
Y
L
A
I
A
S
W
G
R
H
I
Y
Q
-
N
-
T
--
S
R
----
T
PG
D
H
-
F
G
-
R
P
V
--
N
Q
I
V
Y
---
E
H
L
A
G
R
--
I
--
P
L
I
A
S
G
G
I
N
S
P
E
S
A
L
D
A
L
--
Q
--
H
-
A
D
M
V
G
M
S
S
P
F
V
T
E
P
D
F
V
H
K
L
A
E
Q
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
71.78
29%
4
- C2 -
-
5DXX
1
DBR2_ARTAN
A:
[4-364]
-----
K
P
T
L
F
S
A
Y
K
M
G
-
K
F
N
L
S
H
R
V
V
L
A
P
M
T
R
-
C
R
A
I
-
N
A
I
P
N
E
A
-
L
V
E
Y
Y
R
Q
R
S
T
A
-
G
--
G
F
L
I
T
E
G
T
M
I
S
P
S
S
A
G
F
P
H
V
P
G
I
F
T
K
E
Q
V
E
G
W
K
K
V
V
D
A
A
H
K
E
G
A
V
I
F
C
Q
L
W
H
V
G
R
A
S
H
Q
V
Y
Q
------------
P
G-----
G
A
A
P
I
S
S
T
S
K
P
I
S
---------
K
K
W
E
I
L
L
PDA
T
Y
---
G
T
Y
P
E
P
R
-
P
L
A
A
N
E
I
L
E
V
V
E
D
Y
R
V
A
A
I
N
A
I
E
A
G
F
D
G
I
E
I
H
G
A
H
G
Y
L
L
D
Q
F
M
K
D
G
I
N
D
R
T
D
E
Y
G
G
-
S
L
E
N
R
C
K
F
I
L
Q
V
V
Q
A
V
S
A
A
I
G
-----
T
D
R
V
G
I
R
I
S
P
A
I
D
-
H
T
--
D
-
A
M
D
--
S
----
D
P
R
S
L
----
G
L
A
V
I
E
R
L
N
K
-----
L
Q
F
K
L
GS-
L
A
--------
Y
L
H
V
T
---
Q
P
R
Y
T
-
A
-
D
--
G
H
GQTE--------
E
E
E
V
--
A
Q
L
M
K
T
W
R
G
A
Y
--
V
--
G
--
T
F
I
C
C
G
G
Y
-
T
R
E
L
G
L
Q
A
V
--
A
Q
-
G
D
A
D
L
V
A
F
G
R
Y
F
V
S
N
P
D
L
V
L
R
L
K
L
N
A
P
L
N
R
----
Y
D
R
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
71.55
29%
-2
- C2 -
-
1ICP
2
OPR1_SOLLC
B:
[11-355]
---
V
D
K
I
P
L
M
S
P
C
K
M
G
-
K
F
E
L
C
H
R
V
V
L
A
P
L
T
R
-
Q
R
S
-
Y
G
Y
I
P
Q
P
H
-
A
I
L
H
Y
S
Q
R
S
T
N
-
G
--
G
L
L
I
G
E
A
T
V
I
S
E
T
G
I
G
Y
K
D
V
P
G
I
W
T
K
E
Q
V
E
A
W
K
P
I
V
D
A
V
H
A
K
G
G
I
F
F
C
Q
I
W
H
V
G
R
V
S
N
K
D
F
Q
------------
P
N-----
G
E
D
P
I
S
C
T
D
R
G
L
T
P
QIMSNGI
D
I
--------------
A
H
F
T
R
P
R
-
R
L
T
T
D
E
I
P
Q
I
V
N
E
F
R
V
A
A
R
N
A
I
E
A
G
F
D
G
V
E
I
H
G
A
H
G
Y
L
I
D
Q
F
M
K
D
Q
V
N
D
R
S
D
K
Y
G
G
-
S
L
E
N
R
C
R
F
A
L
E
I
V
E
A
V
A
N
E
I
G
-----
S
D
R
V
G
I
R
I
S
P
F
A
H
Y
N
E
--
A
-
G
D
T
--
N
P
T
--
A
---
L
----
G
L
Y
M
V
E
S
L
N
K
-----
Y
------
D
L
A
--------
Y
C
H
V
V
---
E
P
R
M
K
-
T
-------------------
T
E
S
--
L
V
P
M
R
---
K
A
Y
--
K
--
G
--
T
F
I
V
A
G
G
Y
-
D
R
E
D
G
N
R
A
L
--
I
E
-
D
R
A
D
L
V
A
Y
G
R
L
F
I
S
N
P
D
L
P
K
R
F
E
L
N
A
P
L
N
K
----
Y
N
R
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
70.24
30%
3
- C2 -
-
3HGJ
4
?
A:
[2-347]
------
A
L
L
F
T
P
L
E
L
G
-
G
L
R
L
K
N
R
L
A
M
S
P
M
C
Q
-
Y
S
A
T
L
E
G
E
V
T
D
W
-
H
L
L
H
Y
P
T
R
A
L
G
-
G
-
V
G
L
I
L
V
E
A
T
A
V
E
P
L
G
R
I
S
P
Y
D
L
G
I
W
S
E
D
H
L
P
G
L
K
E
L
A
R
R
I
R
E
A
G
A
V
P
G
I
Q
L
A
H
A
G
R
K
A
G
T
A
R
P
------------
W
EGGKPL
G
W
R
V
V
G
P
S
P
I
P
F
D
------------------------
E
G
Y
P
V
P
E
-
P
L
D
E
A
G
M
E
R
I
L
Q
A
F
V
E
G
A
R
R
A
L
R
A
G
F
Q
V
I
E
L
H
M
A
H
G
Y
L
L
S
S
F
L
S
P
L
S
N
Q
R
T
D
A
Y
G
G
-
S
L
E
N
R
M
R
F
P
L
Q
V
A
Q
A
V
R
E
V
V
----
P
R
E
L
P
L
F
V
R
V
S
A
T
D
W
-
G
E
--
G
-
G
W
S
--
L
----
E
---
D
----
T
L
A
F
A
R
R
L
K
E
-----
L
------
G
V
D
--------
L
L
D
C
S
---
S
G
G
V
V
-
L
-
R
--
V
R
----
I
PL
A
P
-
G
F
Q
V
P
F
--
A
D
A
V
R
---
K
R
V
--
G
--
L
--
R
T
G
A
V
G
L
I
T
T
P
E
Q
A
E
T
L
L
--
Q
A
-
G
S
A
D
L
V
L
L
G
R
V
L
L
R
D
P
Y
F
P
L
R
A
A
K
A
L
G
V
A
P
--
E
V
P
P
Q
Y
Q
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
HHSearch
69.30
27%
1
- C2 -
-
1GWJ
1
?
A:
[4-354]
-
T
S
F
S
N
P
G
L
F
T
P
L
Q
L
G
-
S
L
S
L
P
N
R
V
I
M
A
P
L
T
R
-
S
R
T
-
P
D
S
V
P
G
R
L
-
Q
Q
I
Y
Y
G
Q
R
A
---
S
-
A
G
L
I
I
S
E
A
T
N
I
S
P
T
A
R
G
Y
V
Y
T
P
G
I
W
T
D
A
Q
E
A
G
W
K
G
V
V
E
A
V
H
A
K
G
G
R
I
A
L
Q
L
W
H
V
G
R
V
S
H
E
L
V
Q
------------
P
D-----
G
Q
Q
P
V
A
P
S
A
L
K
A
E
---------
G
A
E
C
F
V
E
F
EDGTA
G
L
H
P
T
S
T
P
R
-
A
L
E
T
D
G
I
P
G
I
V
E
D
Y
R
Q
A
A
Q
R
A
K
R
A
G
F
D
M
V
E
V
H
A
A
N
A
C
L
P
N
Q
F
L
A
T
G
T
N
R
R
T
D
Q
Y
G
G
-
S
I
E
N
R
A
R
F
P
L
E
V
V
D
A
V
A
E
V
F
G
-----
P
E
R
V
G
I
R
L
T
P
F
L
E
-
L
---
F
-
G
L
T
--
D
----
D
---
E
P
E
A
M
A
F
Y
L
A
G
E
L
D
R
-----
R
------
G
L
A
--------
Y
L
H
F
N
---
E
P
D
W
I
-
G
-
G
--
D
I
----
T
------
Y
P
E
G
F
--
R
E
Q
M
R
---
Q
R
F
--
K
--
G
--
G
L
I
Y
C
G
N
Y
-
D
A
G
R
A
Q
A
R
L
--
D
D
-
N
T
A
D
A
V
A
F
G
R
P
F
I
A
N
P
D
L
P
E
R
F
R
L
G
A
A
L
N
E
--
P
D
P
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
69.26
30%
4
* C2 *
-
2GQ8
4
?
A:
[1-346]
----
M
T
Q
S
L
F
Q
P
I
T
L
G
-
A
L
T
L
K
N
R
I
V
M
P
P
M
T
R
-
S
R
A
S
Q
P
G
D
V
A
N
H
M
M
A
I
Y
Y
A
Q
R
A
---
S
-
A
G
L
I
V
S
E
G
T
Q
I
S
P
T
A
K
G
Y
A
W
T
P
G
I
Y
T
P
E
Q
I
A
G
W
R
I
V
T
E
A
V
H
A
K
G
C
A
I
F
A
Q
L
W
H
V
G
R
V
T
H
P
D
N
I
------------
D
------
G
Q
Q
P
I
S
S
S
T
L
K
A
E
---------
N
V
K
V
F
V
D
NGSD
E
P
G
F
V
D
V
A
V
P
R
-
A
M
T
K
A
D
I
A
Q
V
I
A
D
Y
R
Q
A
A
L
N
A
M
E
A
G
F
D
G
I
E
L
H
A
A
N
G
Y
L
I
N
Q
F
I
D
S
E
A
N
N
R
S
D
E
Y
G
G
-
S
L
E
N
R
L
R
F
L
D
E
V
V
A
A
L
V
D
A
I
G
-----
A
E
R
V
G
V
R
L
A
P
L
T
T
-
L
N
--
G
-
T
V
D
--
A
----
D
P
I
L
T
----
Y
T
A
A
A
A
L
L
N
K
-----
H
------
R
I
V
--------
Y
L
H
I
A
---
E
V
D
W
D
-
D
-
A
--
P
-----------
D
T
P
V
S
F
--
K
R
A
L
R
---
E
A
Y
--
Q
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G
--
V
L
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-
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Y
N
A
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K
A
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--
N
D
-
G
L
A
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P
D
L
P
E
R
L
R
H
G
Y
P
L
A
E
--
H
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
69.00
28%
-2
- C2 -
-
5EPD
-
?
A:
[25-363]
-------
T
L
F
Q
P
T
S
L
G
-
A
I
T
L
A
N
R
I
V
M
A
P
L
T
R
-
N
R
A
G
A
G
F
V
P
G
E
L
-
T
A
G
Y
Y
A
Q
R
A
---
S
-
A
G
L
I
I
S
E
A
T
Q
I
S
Q
Q
G
Q
G
Y
Q
D
T
P
G
I
Y
T
Q
A
Q
I
D
G
W
K
K
V
T
A
A
V
H
K
K
G
G
R
I
V
L
Q
L
W
H
V
G
R
I
S
H
V
N
L
Q
------------
P
N-----
G
G
A
P
V
A
P
S
A
I
R
A
E
---------
V
K
T
F
V
NN
G
F
------
V
D
V
S
E
P
R
-
A
L
E
L
E
E
L
A
G
I
V
D
D
F
R
K
A
A
A
N
S
I
E
A
G
F
D
G
V
E
V
H
G
A
N
G
Y
L
L
E
Q
F
A
K
D
G
A
N
M
R
T
D
T
Y
G
G
-
S
V
E
N
R
A
R
L
M
L
E
V
T
A
A
V
A
Q
E
I
G
-----
P
E
R
T
G
I
R
I
S
P
V
S
P
-
A
---
N
-
G
I
S
--
C
SD
P
Q
T
---
Q
----
Y
D
Y
I
V
D
K
L
D
A
-----
L
------
G
I
A
--------
Y
I
H
V
V
---
E
------------------------
P
F
D
---
Y
G
S
L
R
---
R
R
F
--
S
--
R
--
T
Y
I
A
N
----
D
L
E
L
A
T
S
H
L
--
A
D
-
G
R
A
D
L
I
A
F
G
R
P
F
I
A
N
P
D
L
V
E
R
L
Q
S
G
A
P
L
A
E
--
V
N
A
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
68.80
27%
2
- C2 -
-
2R14
2
?
A:
[8-354]
-----
N
P
G
L
F
T
P
L
Q
L
G
-
S
L
S
L
P
N
R
V
I
M
A
P
L
T
R
-
S
R
T
-
P
D
S
V
P
G
R
L
-
Q
Q
I
Y
Y
G
Q
R
A
---
S
-
A
G
L
I
I
S
E
A
T
N
I
S
P
T
A
R
G
Y
V
Y
T
P
G
I
W
T
D
A
Q
E
A
G
W
K
G
V
V
E
A
V
H
A
K
G
G
R
I
A
L
Q
L
W
H
V
G
R
V
S
H
E
L
V
Q
------------
P
D-----
G
Q
Q
P
V
A
P
S
A
L
K
A
E
---------
G
A
E
C
F
V
E
F
EDGTA
G
L
H
P
T
S
T
P
R
-
A
L
E
T
D
E
I
P
G
I
V
E
D
Y
R
Q
A
A
Q
R
A
K
R
A
G
F
D
M
V
E
V
H
A
A
N
A
C
L
P
N
Q
F
L
A
T
G
T
N
R
R
T
D
Q
Y
G
G
-
S
I
E
N
R
A
R
F
P
L
E
V
V
D
A
V
A
E
V
F
G
-----
P
E
R
V
G
I
R
L
T
P
F
L
E
-
L
---
F
-
G
L
T
--
D
----
D
---
E
P
E
A
M
A
F
Y
L
A
G
E
L
D
R
-----
R
------
G
L
A
--------
Y
L
H
F
N
---
E
P
D
--------------
T
------
Y
P
E
G
F
--
R
E
Q
M
R
---
Q
R
F
--
K
--
G
--
G
L
I
Y
C
G
N
Y
-
D
A
G
R
A
Q
A
R
L
--
D
D
-
N
T
A
D
A
V
A
F
G
R
P
F
I
A
N
P
D
L
P
E
R
F
R
L
G
A
A
L
N
E
--
P
D
P
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
68.57
31%
23
- C2 -
-
3L5L
4
?
A:
[2-346]
------
S
A
L
F
E
P
Y
T
L
K
-
D
V
T
L
R
N
R
I
A
I
P
P
M
C
Q
-
Y
M
A
E
-
D
G
M
I
N
D
W
-
H
H
V
H
L
A
G
L
A
R
G
-
G
-
A
G
L
L
V
V
E
A
T
A
V
A
P
E
G
R
I
T
P
G
C
A
G
I
W
S
D
A
H
A
Q
A
F
V
P
V
V
Q
A
I
K
A
A
G
S
V
P
G
I
Q
I
A
H
A
G
R
K
A
S
A
N
R
P
WEGDDHIAADDT
R
------
G
W
E
T
I
A
P
S
A
I
A
F
G
---------
A
--------------
H
L
P
K
V
P
R
-
E
M
T
L
D
D
I
A
R
V
K
Q
D
F
V
D
A
A
R
R
A
R
D
A
G
F
E
W
I
E
L
H
F
A
H
G
Y
L
G
Q
S
F
F
S
E
H
S
N
K
R
T
D
A
Y
G
G
-
S
F
D
N
R
S
R
F
L
L
E
T
L
A
A
V
R
E
V
W
----
P
E
N
L
P
L
T
A
R
F
G
V
L
E
Y
-
D
G
R-
D
-
E
Q
T
--
L
----
E
---
E
----
S
I
E
L
A
R
R
F
K
A
-----
G
------
G
L
D
--------
L
L
S
V
S
---
V
G
F
T
I
-
P
-
D
--
T
N
----
I
PW
G
P
-
A
F
M
G
P
I
--
A
E
R
V
R
---
R
E
A
--
K
--
L
--
P
V
T
S
A
W
G
F
G
T
P
Q
L
A
E
A
A
L
--
Q
A
-
N
Q
L
D
L
V
S
V
G
R
A
H
L
A
D
P
H
W
A
Y
F
A
A
K
E
L
G
V
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
68.24
28%
-11
- C2 -
-
4B5N
2
?
A:
[7-344]
--
V
N
S
V
E
N
L
F
D
T
Y
K
L
N
D
T
I
T
L
K
N
R
I
L
M
A
P
L
T
R
-
C
M
A
D
A
N
L
V
P
T
D
D
-
M
V
A
Y
Y
A
R
R
A
-
E
---
A
G
L
I
I
S
E
A
T
I
I
R
P
D
A
Q
G
Y
P
N
T
P
G
I
F
T
Q
A
Q
I
A
G
W
R
K
V
T
D
A
V
H
A
N
G
G
K
I
F
V
Q
L
W
H
T
G
R
V
A
H
P
H
F
F
------------
G
------
G
G
D
V
L
A
P
S
A
Q
K
I
E
---------
G
SVPRMRE-------
L
T
Y
V
T
P
K
-
A
V
T
V
E
D
I
Q
G
L
V
R
D
Y
A
K
A
A
E
N
V
I
E
A
G
F
D
G
V
E
I
H
G
A
N
G
Y
L
I
D
Q
F
L
H
H
D
S
N
R
R
T
D
E
Y
G
G
-
T
P
V
N
M
S
R
F
A
L
E
V
V
D
A
I
I
A
R
I
G
-----
H
D
R
T
G
L
R
I
S
P
G
A
Y
-
F
N
--
M
-
A
S
D
--
S
----
R
---
D
R
V
V
-
F
D
Y
L
L
P
E
L
E
K
-----
R
------
D
L
A
--------
F
V
H
I
G
---
I
F
D
D
S
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I
-
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---
F
----
D
--
Y
---
L
G
G
T
A
--
S
S
Y
V
R
---
A
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Y
--
G
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K
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L
V
G
V
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S
Y
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S
A
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A
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A
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A
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D
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D
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F
I
A
N
P
D
Y
V
A
K
V
R
N
S
E
E
L
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Fugue
67.29
24%
-4
- C2 -
-
1PS9
5
FADH_ECOLI
A:
[1-671]
----
S
Y
P
S
L
F
A
P
L
D
L
-
G
F
T
T
L
K
N
R
V
L
M
G
S
M
H
T
-
G
L
E
E
-
Y
P
D
G
A
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R
-
L
A
A
F
Y
A
E
R
A
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R
H
G
-
V
A
L
I
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G
G
I
A
P
D
L
T
G
V
G
M
E
G
G
A
M
L
N
D
A
S
Q
I
P
H
H
R
T
I
T
E
A
V
H
Q
E
G
G
K
I
A
L
Q
I
L
H
T
G
R
Y
S
Y
Q
P
H
L
------------
V
------
A
P
S
A
L
Q
A
P
I
-----------------------------
N
R
F
V
P
H
-
E
L
S
H
E
E
I
L
Q
L
I
D
N
F
A
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C
A
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A
R
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A
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Y
D
G
V
E
V
M
G
S
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G
Y
L
I
N
E
F
L
T
L
R
T
N
Q
R
S
D
Q
W
G
G
-
D
Y
R
N
R
M
R
F
A
V
E
V
V
R
A
V
R
E
R
V
G
----
N
D
F
I
I
I
Y
R
L
S
M
L
D
L
-
V
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--
D
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G
G
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----
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---
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----
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L
A
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A
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A
-----
A
------
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A
T
--------
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---
I
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----
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M
P
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A
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AHSEIGGQ
F
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A
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IPGKEE
F
Y
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T
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Y
Y
R
R
M
I
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GVTLKLNHTVTADQLQAFD
E
T
I
L
A
S
G
I
V
P
R
TPPIDGIDHPKVLSYLDVLRDKAPVGN
K
V
A
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CG
G
I
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QPGESTSQN
I
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GIDSSLQQAGGLSPQ
G
M
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SPRQ
I
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M
L
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RKASKPGQGLGKTT
G
W
I
H
R
T
T
L
L
S
R
G
V
K
M
I
P
GVSYQKIDDD
G
L
H
V
V
I
NG
E
T
Q
V
L
AVD
N
V
V
I
CA
G
Q
E
P
N
RALAQ
P
L
I
D
S
G
K
T
V
H
L
I
G
GCDVAMELD
A
R
R
A
I
A
Q
G
T
R
L
A
L
E
I
66
HHSearch
67.18
28%
-2
- C2 -
-
4AB4
4
?
B:
[2-333]
------
T
T
L
F
D
P
I
K
L
G
-
D
L
Q
L
P
N
R
I
I
M
A
P
L
T
R
-
C
R
A
D
E
G
R
V
P
N
A
L
-
M
A
E
Y
Y
V
Q
R
A
---
S
-
A
G
L
I
L
S
E
A
T
S
V
S
P
M
G
V
G
Y
P
D
T
P
G
I
W
N
D
E
Q
V
R
G
W
N
N
V
T
K
A
V
H
A
A
G
G
R
I
F
L
Q
L
W
H
V
G
R
I
S
H
P
S
Y
L
------------
N
------
G
E
L
P
V
A
P
S
A
I
Q
P
K
---------
G
HVSLVRPL------
S
D
Y
P
T
P
R
-
A
L
E
T
E
E
I
N
D
I
V
E
A
Y
R
S
G
A
E
N
A
K
A
A
G
F
D
G
V
E
I
H
G
A
N
G
Y
L
L
D
Q
F
L
Q
S
S
T
N
Q
R
T
D
R
Y
G
G
-
S
L
E
N
R
A
R
L
L
L
E
V
T
D
A
A
I
E
V
W
G
-----
A
Q
R
V
G
V
H
L
A
P
R
A
D
-
A
H
DM
G
D
A
D
R
--
A
----
E
---
T
----
F
T
Y
V
A
R
E
L
G
K
-----
R
------
G
I
A
--------
F
I
C
S
R
---
E
R
E
A
---------------------
D
D
S
I
--
G
P
L
I
K
---
E
A
F
--
G
--
G
--
P
Y
I
V
N
E
R
F
-
D
K
A
S
A
N
A
A
L
--
A
S-
G
K
A
D
A
V
A
F
G
V
P
F
I
A
N
P
D
L
P
A
R
L
A
A
D
A
P
L
N
E
--
A
H
P
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
66.89
30%
9
- C2 -
-
3KRU
2
?
A:
[13-336]
------------------
I
T
I
K
N
R
I
M
M
S
P
M
C
M
-
Y
S
A
S
T
D
G
M
P
N
D
W
-
H
I
V
H
Y
A
T
R
A
I
G
-
G
-
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
N
I
------------
S
------
Y
E
D
V
V
G
P
S
P
I
K
A
G
------------------------
D
R
Y
K
L
P
R
-
E
L
S
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
-
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
P
E
--
N
K
P
I
F
V
--
R
V
S
A
D
D
Y
-
M
E
--
G
-
G
I
N
--
I
----
D
---
M
----
M
V
E
Y
I
N
M
I
K
D
------------
K
V
D
LID
V
S
S
G
G
L
L
N
V
D
---
I
N
L
Y
P
------
G
Y
----
Q
--
V
K
-
Y
A
E
--------------
T
I
K
K
R
C
N
I
--
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
--
R
-
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
T
S
K
E
D
W
----
P
K
Q
Y
E
R
A
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
66.55
27%
3
- C2 -
-
4A3U
2
?
B:
[2-340]
------
P
S
L
F
D
P
I
R
F
G
-
A
F
T
A
K
N
R
I
W
M
A
P
L
T
R
-
G
R
A
T
R
D
H
V
P
T
E
I
-
M
A
E
Y
Y
A
Q
R
A
---
S
-
A
G
L
I
I
S
E
A
T
G
I
S
Q
E
G
L
G
W
P
Y
A
P
G
I
W
S
D
A
Q
V
E
A
W
L
P
I
T
Q
A
V
H
D
A
G
G
L
I
F
A
Q
L
W
H
M
G
R
M
V
P
S
N
V
S
-------------------
G
M
Q
P
V
A
P
S
A
S
Q
A
P
---------
G
LGHTYDGK------
K
P
Y
D
V
A
R
-
A
L
R
L
D
E
I
P
R
L
L
D
D
Y
E
K
A
A
R
H
A
L
K
A
G
F
D
G
V
Q
I
H
A
A
N
G
Y
L
I
D
E
F
I
R
D
S
T
N
H
R
H
D
E
Y
G
G
-
A
V
E
N
R
I
R
L
L
K
D
V
T
E
R
V
I
A
T
I
G
-----
K
E
R
T
A
V
R
L
S
P
N
G
E
-
I
Q
--
G
-
T
V
D
SH
P
----
E
---
Q
V---
F
I
P
A
A
K
M
L
S
D
-----
L
------
D
I
A
--------
F
L
G
M
R
---
E
G
A
V
D
-
G
-
T
--------
F
--
G
K
-
T
D
Q
P
K
L
--
S
P
E
I
R
---
K
V
F
--
K
--
P
--
P
L
V
-
L
N
Q
D
Y
T
F
E
T
A
Q
A
A
L
--
D
S-
G
V
A
D
A
I
S
F
G
R
P
F
I
G
N
P
D
L
P
R
R
F
F
E
K
A
P
L
T
K
----
D
V
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.38
33%
24
- C2 -
-
3GR7
1
NAMA_GEOKA
B:
[13-316]
-----------------
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
-
H
K
I
H
Y
P
A
R
A
-
V
-
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
Q
V
------------
P
------
G
E
--
I
I
A
P
S
A
V
P
F
---------
D
--------------
D
S
S
P
T
P
K
-
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
-
S
P
E
N
R
Y
R
F
L
G
E
----
V
I
D
A
V
R
E
V
W
D
G
P
L
F
V
--
R
I
S
A
S
D
Y
-
H
P
--
D
-
G
L
T
--
A
----
K
---
D
----
Y
V
P
Y
A
K
R
M
K
E
-----
Q
------
G
V
D
--------
L
V
D
V
S
---
S
G
A
I
--
V
-
P
--
A
R
----
M
--
N
V
-
Y
P
G
Y
Q
V
PF
A
E
L
I
R
---
R
--
E
A
D
--
I
--
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
--
Q
NG
R
-
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
66.05
33%
23
- C2 -
-
3GR7
1
NAMA_GEOKA
A:
[13-316]
-----------------
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
-
H
K
I
H
Y
P
A
R
A
-
V
-
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
Q
V
------------
P
------
G
E
--
I
I
A
P
S
A
V
P
F
---------
D
--------------
D
S
S
P
T
P
K
-
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
-
S
P
E
N
R
Y
R
F
L
G
E
----
V
I
D
A
V
R
E
V
W
D
G
P
L
F
V
--
R
I
S
A
S
D
Y
-
H
P
--
D
-
G
L
T
--
A
----
K
---
D
----
Y
V
P
Y
A
K
R
M
K
E
-----
Q
------
G
V
D
--------
L
V
D
V
S
---
S
G
A
I
--
V
-
P
--
A
R
----
M
--
N
V
-
Y
P
G
Y
Q
V
P
F
A
E
L
I
R
---
R
--
E
A
D
--
I
--
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
--
Q
N
G
R
-
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
HHSearch
65.89
25%
-7
- C2 -
-
3GKA
1
?
B:
[8-341]
----
H
M
P
S
L
F
D
P
L
T
I
G
-
D
L
T
L
A
N
R
I
I
M
A
P
L
T
R
-
A
R
A
G
D
T
R
T
P
N
A
L
-
M
A
R
Y
Y
A
E
R
A
---
S
-
A
G
L
I
I
S
E
A
T
S
V
T
P
Q
G
V
G
Y
A
S
T
P
G
I
W
S
P
E
Q
V
D
G
W
R
L
V
T
D
A
V
H
A
A
G
G
R
I
F
L
Q
L
W
H
V
G
R
V
S
D
P
V
F
L
------------
D
------
G
A
L
P
V
A
P
S
A
I
A
P
G
---------
G
HVSLVRPQ------
R
P
Y
V
T
P
R
-
A
L
E
L
D
E
I
P
G
V
V
A
A
F
R
R
G
A
E
N
A
R
A
A
G
F
D
G
V
E
V
H
G
A
N
G
Y
L
L
D
Q
F
L
Q
D
S
A
N
R
R
T
D
A
Y
G
G
-
S
I
E
N
R
A
R
L
L
L
E
V
V
D
A
A
I
D
V
W
S
-----
A
A
R
V
G
V
H
L
A
P
R
G
D
-
A
H
TM
G
-
D
S
D
P
-
A
----
A
---
T
----
F
G
H
V
A
R
E
L
G
R
-----
R
------
R
I
A
--------
F
L
F
A
R
---
E
S
F
G
---------------------
G
D
A
I
--
G
Q
Q
L
K
---
A
A
F
--
G
--
G
--
P
F
I
V
N
E
N
F
-
T
L
D
S
A
Q
A
A
L
--
D
A
-
G
Q
A
D
A
V
A
W
G
K
L
F
I
A
N
P
D
L
P
R
R
F
K
L
N
A
P
L
N
E
--
P
N
A
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.79
30%
9
- C2 -
-
3KRZ
3
?
A:
[13-336]
------------------
I
T
I
K
N
R
I
M
M
S
P
M
C
M
-
Y
S
A
S
T
D
G
M
P
N
D
W
-
H
I
V
H
Y
A
T
R
A
I
G
-
G
-
V
G
L
I
M
Q
E
A
T
A
V
E
S
R
G
R
I
T
D
H
D
L
G
I
W
N
D
E
Q
V
K
E
L
K
K
I
V
D
I
C
K
A
N
G
A
V
M
G
I
Q
L
A
H
A
G
R
---
K
C
N
I
------------
S
------
Y
E
D
V
V
G
P
S
P
I
K
A
G
------------------------
D
R
Y
K
L
P
R
-
E
L
S
V
E
E
I
K
S
I
V
K
A
F
G
E
A
A
K
R
A
N
L
A
G
Y
D
V
V
E
I
H
A
A
H
G
Y
L
I
H
E
F
L
S
P
L
S
N
K
R
K
D
E
Y
G
N
-
S
I
E
N
R
A
R
F
L
I
E
V
I
D
E
V
R
K
N
W
P
E
--
N
K
P
I
F
V
--
R
V
S
A
D
D
Y
-
M
E
--
G
-
G
I
N
--
I
----
D
---
M
----
M
V
E
Y
I
N
M
I
K
D
------------
K
V
D
LID
V
S
S
G
G
L
L
N
V
D
---
I
N
L
Y
P
------
G
Y
----
Q
--
V
K
-
Y
A
E
--------------
T
I
K
K
R
C
N
I
--
K
T
S
A
V
G
L
I
T
T
Q
E
L
A
E
E
I
L
S
N
E
--
R
-
A
D
L
V
A
L
G
R
E
L
L
R
N
P
Y
W
V
L
H
T
Y
T
S
K
E
D
W
----
P
K
Q
Y
E
R
A
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
65.49
33%
24
- C2 -
-
3GR8
2
NAMA_GEOKA
B:
[13-316]
-----------------
G
L
T
L
K
N
R
I
V
M
S
P
M
C
M
Y
S
C
D
T
K
D
G
A
V
R
T
W
-
H
K
I
H
Y
P
A
R
A
-
V
-
G
Q
V
G
L
I
I
V
E
A
T
G
V
T
P
Q
G
R
I
S
E
R
D
L
G
I
W
S
D
D
H
I
A
G
L
R
E
L
V
G
L
V
K
E
H
G
A
A
I
G
I
Q
L
A
H
A
G
R
---
K
S
Q
V
------------
P
------
G
E
--
I
I
A
P
S
A
V
P
F
---------
D
--------------
D
S
S
P
T
P
K
-
E
M
T
K
A
D
I
E
E
T
V
Q
A
F
Q
N
G
A
R
R
A
K
E
A
G
F
D
V
I
E
I
H
A
A
H
G
Y
L
I
N
E
F
L
S
P
L
S
N
R
R
Q
D
E
Y
G
G
-
S
P
E
N
R
Y
R
F
L
G
E
----
V
I
D
A
V
R
E
V
W
D
G
P
L
F
V
--
R
I
S
A
S
D
Y
-
H
P
--
D
-
G
L
T
--
A
----
K
---
D
----
Y
V
P
Y
A
K
R
M
K
E
-----
Q
------
G
V
D
--------
L
V
D
V
S
---
S
G
A
I
--
V
-
P
--
A
R
----
M
--
N
V
-
Y
P
G
Y
Q
V
PF
A
E
L
I
R
---
R
--
E
A
D
--
I
--
P
T
G
A
V
G
L
I
T
S
G
W
Q
A
E
E
I
L
--
Q
NG
R
-
A
D
L
V
F
L
G
R
E
L
L
R
N
P
Y
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
39.03
39%
-2
- C2 -
-
4RNX
1
OYE1_SACPS
B:
[3-95]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
N
P
Q
H
S
L
T
K
D
E
I
K
Q
Y
I
K
E
Y
V
Q
A
A
K
N
S
I
A
A
G
A
D
G
V
E
I
H
S
A
N
G
Y
L
L
N
Q
F
L
D
P
H
S
N
T
R
T
D
E
Y
G
G
-
S
I
E
N
R
A
R
F
T
L
E
V
V
D
A
L
V
E
A
I
G
H
E
K
-----
V
G
L
R
L
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
38.45
39%
4
- C2 -
-
4RNX
2
OYE1_SACPS
A:
[3-95]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
N
P
Q
H
S
L
T
K
D
E
I
K
Q
Y
I
K
E
Y
V
Q
A
A
K
N
S
I
A
A
G
A
D
G
V
E
I
H
S
A
N
G
Y
L
L
N
Q
F
L
D
P
H
S
N
T
R
T
D
E
Y
G
G
-
S
I
E
N
R
A
R
F
T
L
E
V
V
D
A
L
V
E
A
I
G
H
E
K
-----
V
G
L
R
L
S
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------