@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : I3TZW1: (2017-12-17 )
MEFLKEIIHNSWQEVLSSEFSKDYYLHLREFLKKEYASQKIHPDMYHIYEALELTPYEEVKVVILGQDPYHGENQAHGLSFSVQPGVKIPPSLRNIYKELYDDLGIAPVQHGNLVSWAKQGVLLLNTVLTVREGQAYSHRGKGWERLTDTIIEKLNEREKPIVFILWGKPAQEKIKMIDKSRHIIITSPHPSPLSASRGFFGSKPFSKTNDALLALGEEPIDWQLPETV
Atome Classification :
(53 SA)
.........10........20........30......-..-40.-.......50........60........70........80.....-...-90.....---.---..100..-.-....110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
E
F
L
K
E
I
I
H
N
S
W
Q
E
V
L
S
S
E
FS
K
D
Y
Y
L
H
L
R
E
F
L
K
K
E
Y
A-SQ-KIH-
P
D
M
Y
H
I
Y
E
A
L
ELT
P
Y
E
E
V
K
V
V
I
L
GQDPYHGENQAH
G
L
S
F
SVQPG-VKI-
P
P
S
L
R
N
I
---
Y
---
K
E
L
Y
D
DL-G-IAPVQHG
N
L
V
S
W
A
KQ
G
V
L
L
L
N
T
V
L
T
VREGQAYSHRGK
G
W
E
R
L
T
D
T
I
I
E
K
L
NEREK
P
I
V
F
I
L
WGK
P
A
Q
E
K
I
K
M
IDKSR
H
I
I
I
TSPHPSPLSASRGFFGSKPFSKTND
A
L
L
ALGEEPIDWQLPETV
74
HHSearch
97.45
63%
-102
- C8 -
-
3ZOQ
1
UNG_BACSU
A:
[3-224]
-----
Q
L
L
Q
D
S
W
W
N
Q
L
K
E
E
F
E
K
P
Y
Y
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
K
P
G
-
V
K
Q
-
P
P
S
L
K
N
I
---
F
---
L
E
L
Q
Q
D
I
-
G
-
C
S
I
P
N
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
K
G
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
K
D
--
75
HHSearch
97.20
63%
-100
- C8 -
-
3ZOR
-
UNG_BACSU
A:
[3-224]
-----
Q
L
L
Q
D
S
W
W
N
Q
L
K
E
E
F
E
K
P
Y
Y
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
K
P
G
-
V
K
Q
-
P
P
S
L
K
N
I
---
F
---
L
E
L
Q
Q
D
I
-
G
-
C
S
I
P
N
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
K
G
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
K
D
--
1
PsiBlast_PDB
97.08
62%
-102
- C8 -
-
3ZOQ
1
UNG_BACSU
A:
[3-224]
-----
Q
L
L
Q
D
S
W
W
N
Q
L
K
E
E
F
E
K
P
Y
Y
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
K
P
G
-
V
K
Q
-
P
P
S
L
K
N
I
---
F
---
L
E
L
Q
Q
D
I
-
G
-
C
S
I
P
N
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
K
G
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
K
D
--
2
PsiBlast_PDB
96.83
62%
-100
- C8 -
-
3ZOR
-
UNG_BACSU
A:
[3-224]
-----
Q
L
L
Q
D
S
W
W
N
Q
L
K
E
E
F
E
K
P
Y
Y
Q
E
L
R
E
M
L
K
R
E
Y
A
-
E
Q
-
T
I
Y
-
P
D
S
R
D
I
F
N
A
L
H
Y
T
S
Y
D
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
Q
G
L
S
F
S
V
K
P
G
-
V
K
Q
-
P
P
S
L
K
N
I
---
F
---
L
E
L
Q
Q
D
I
-
G
-
C
S
I
P
N
H
G
S
L
V
S
W
A
K
Q
G
V
L
L
L
N
T
V
L
T
V
R
R
G
Q
A
N
S
H
K
G
K
G
W
E
R
L
T
D
R
I
I
D
V
L
S
E
R
E
R
P
V
I
F
I
L
W
G
R
H
A
Q
M
K
K
E
R
I
D
T
S
K
H
F
I
I
E
S
T
H
P
S
P
F
S
A
R
N
G
F
F
G
S
R
P
F
S
R
A
N
A
Y
L
E
K
M
G
E
A
P
I
D
W
C
I
K
D
--
4
PsiBlast_PDB
88.43
57%
-99
- C8 -
-
3WDG
-
UNG_STAAR
A:
[3-216]
-----------
W
S
Q
I
F
H
D
I
T
T
K
H
D
F
K
A
M
H
D
F
L
E
K
E
Y
S
-
T
A
-
I
V
Y
-
P
D
R
E
N
I
Y
Q
A
F
D
L
T
P
F
E
N
I
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
A
F
S
V
Q
P
N
-
A
K
F
-
P
P
S
L
R
N
M
---
Y
---
K
E
L
A
D
D
I
-
G
-
C
V
-
R
Q
T
P
H
L
Q
D
W
A
R
E
G
V
L
L
L
N
T
V
L
T
V
R
Q
G
E
A
N
S
H
R
D
I
G
W
E
T
F
T
D
E
I
I
K
A
V
S
D
Y
K
E
H
V
V
F
I
L
W
G
K
P
A
Q
Q
K
I
K
L
I
D
T
S
K
H
C
I
I
K
S
V
H
P
S
P
L
S
A
Y
R
G
F
F
G
S
K
P
Y
S
K
A
N
T
Y
L
E
S
V
G
K
S
P
I
N
W
C
E
S
---
5
PsiBlast_PDB
85.04
58%
-25
- C8 -
-
2BOO
-
UNG_DEIRA
A:
[27-244]
-----------
W
Q
E
A
L
L
P
E
F
S
A
P
Y
F
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
R
P
G
-
V
R
V
-
P
P
S
L
R
N
I
---
Y
---
K
E
L
T
E
D
I
P
G
-
F
V
A
P
K
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
G
Q
A
N
S
H
Q
G
K
G
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
-
E
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
P
A
T
V
79
HHSearch
84.92
57%
-26
- C8 -
-
2BOO
-
UNG_DEIRA
A:
[19-243]
---
I
P
A
N
L
P
E
D
W
Q
E
A
L
L
P
E
F
S
A
P
Y
F
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
R
P
G
-
V
R
V
-
P
P
S
L
R
N
I
---
Y
---
K
E
L
T
E
D
I
P
G
-
F
V
A
P
K
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
G
Q
A
N
S
H
Q
G
K
G
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
E
-
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
P
A
T
-
6
PsiBlast_PDB
83.73
58%
-28
- C8 -
-
3UFM
-
UNG_DEIRA
A:
[27-244]
-----------
W
Q
E
A
L
L
P
E
F
S
A
P
Y
F
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
R
P
G
-
V
R
V
-
P
P
S
L
R
N
I
---
Y
---
K
E
L
T
E
D
I
P
G
-
F
V
A
P
K
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
G
Q
A
N
S
H
Q
G
K
G
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
-
E
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
P
A
T
V
80
HHSearch
82.05
56%
-22
- C8 -
-
4UQM
3
UNG_DEIRA
A:
[19-243]
---
I
P
A
N
L
P
E
D
W
Q
E
A
L
L
P
E
F
S
A
P
Y
F
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
R
P
G
-
V
R
V
-
P
P
S
L
R
N
I
---
Y
---
K
E
L
T
E
D
I
P
G
-
F
V
A
P
K
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
A
Q
A
N
S
H
Q
G
K
G
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
E
-
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
P
A
T
-
7
PsiBlast_PDB
82.01
57%
-23
- C8 -
-
4UQM
3
UNG_DEIRA
A:
[27-244]
-----------
W
Q
E
A
L
L
P
E
F
S
A
P
Y
F
H
E
L
T
D
F
L
R
Q
E
R
K
-
E
Y
-
T
I
Y
-
P
P
A
P
D
V
F
N
A
L
R
Y
T
P
L
G
E
V
K
V
L
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
S
F
S
V
R
P
G
-
V
R
V
-
P
P
S
L
R
N
I
---
Y
---
K
E
L
T
E
D
I
P
G
-
F
V
A
P
K
H
G
Y
L
R
S
W
A
E
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
A
Q
A
N
S
H
Q
G
K
G
W
E
H
F
T
D
A
V
I
K
A
V
N
A
K
E
E
R
V
V
F
I
L
W
G
S
Y
A
R
K
K
K
K
L
I
T
G
K
N
H
V
V
I
E
S
G
H
P
S
P
L
S
-
E
Q
Y
F
F
G
T
R
P
F
S
K
T
N
E
A
L
E
K
A
G
R
G
P
V
E
W
Q
L
P
A
T
V
30
PsiBlast_CBE
81.36
50%
-30
- C8 -
-
1OKB
1
?
A:
[1-221]
M
E
F
F
G
E
----
T
W
R
R
E
L
A
A
E
F
E
K
P
Y
F
K
Q
L
M
S
F
V
A
D
E
R
S
-
R
H
-
T
V
Y
-
P
P
A
D
Q
V
Y
S
W
T
E
M
C
D
I
Q
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
K
P
-
V
P
P
-
P
P
S
L
V
N
I
---
Y
---
K
E
L
C
T
D
I
D
G
-
F
K
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
D
R
G
W
E
T
F
T
D
A
V
I
K
W
L
S
V
N
R
E
G
V
V
F
L
L
W
G
S
Y
A
H
K
K
G
A
T
I
D
R
K
R
H
H
V
L
Q
A
V
H
P
S
P
L
S
A
H
R
G
F
L
G
C
K
H
F
S
K
A
N
G
L
L
K
L
S
G
T
E
P
I
N
W
R
-----
23
PsiBlast_CBE
81.28
50%
-30
- C8 -
-
3FCK
1
UNG_HUMAN
B:
[2-221]
-
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
29
PsiBlast_CBE
81.16
50%
-30
- C8 -
-
1OKB
1
?
B:
[1-221]
M
E
F
F
G
E
----
T
W
R
R
E
L
A
A
E
F
E
K
P
Y
F
K
Q
L
M
S
F
V
A
D
E
R
S
-
R
H
-
T
V
Y
-
P
P
A
D
Q
V
Y
S
W
T
E
M
C
D
I
Q
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
K
P
-
V
P
P
-
P
P
S
L
V
N
I
---
Y
---
K
E
L
C
T
D
I
D
G
-
F
K
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
D
R
G
W
E
T
F
T
D
A
V
I
K
W
L
S
V
N
R
E
G
V
V
F
L
L
W
G
S
Y
A
H
K
K
G
A
T
I
D
R
K
R
H
H
V
L
Q
A
V
H
P
S
P
L
S
A
H
R
G
F
L
G
C
K
H
F
S
K
A
N
G
L
L
K
L
S
G
T
E
P
I
N
W
R
-----
17
PsiBlast_PDB
80.78
50%
-29
- C8 -
-
1AKZ
-
UNG_HUMAN
A:
[82-302]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
76
HHSearch
80.74
50%
-28
* C8 *
-
3FCI
1
UNG_HUMAN
A:
[2-222]
-----
E
F
F
G
E
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
-
E
D
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
----
24
PsiBlast_CBE
80.70
50%
-25
- C8 -
-
3FCI
1
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
22
PsiBlast_CBE
80.38
50%
-27
- C8 -
-
3FCL
1
UNG_HUMAN
A:
[2-221]
-
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
27
PsiBlast_CBE
80.27
50%
-23
- C8 -
-
2SSP
2
UNG_HUMAN
E:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
A
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
12
PsiBlast_PDB
79.97
50%
-27
- C8 -
-
1SSP
3
UNG_HUMAN
E:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
10
PsiBlast_PDB
79.95
51%
-26
- C8 -
-
3TKB
2
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
G
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
R
-----
21
PsiBlast_CBE
79.72
50%
-25
- C8 -
-
3FCL
2
UNG_HUMAN
B:
[2-221]
-
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
16
PsiBlast_PDB
79.23
50%
-21
- C8 -
-
2HXM
1
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
13
PsiBlast_PDB
79.07
50%
-23
- C8 -
-
1EMH
2
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
20
PsiBlast_PDB
78.91
50%
-23
- C8 -
-
3FCF
1
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
15
PsiBlast_PDB
78.56
50%
-24
- C8 -
-
1Q3F
3
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
14
PsiBlast_PDB
78.37
50%
-24
- C8 -
-
1EMJ
3
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
77
HHSearch
77.81
50%
-22
- C8 -
-
2OXM
2
UNG_HUMAN
A:
[2-222]
-----
E
F
F
G
E
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
-
E
D
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
E
----
18
PsiBlast_PDB
77.22
50%
-18
- C8 -
-
2OXM
2
UNG_HUMAN
A:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
L
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
31
PsiBlast_CBE
76.53
49%
-22
- C8 -
-
4SKN
3
UNG_HUMAN
E:
[1-221]
M
E
F
F
G
E
----
S
W
K
K
H
L
S
G
E
F
G
K
P
Y
F
I
K
L
M
G
F
V
A
E
E
R
K
-
H
Y
-
T
V
Y
-
P
P
P
H
Q
V
F
T
W
T
Q
M
C
D
I
K
D
V
K
V
V
I
L
G
Q
N
P
Y
H
G
P
N
Q
A
H
G
L
C
F
S
V
Q
R
P
-
V
P
P
-
P
P
S
L
E
N
I
---
Y
---
K
E
L
S
T
D
I
E
D
-
F
V
H
P
G
H
G
D
L
S
G
W
A
K
Q
G
V
L
L
L
N
A
V
L
T
V
R
A
H
Q
A
N
S
H
K
E
R
G
W
E
Q
F
T
D
A
V
V
S
W
L
N
Q
N
S
N
G
L
V
F
L
L
W
G
S
Y
A
Q
K
K
G
S
A
I
D
R
K
R
H
H
V
L
Q
T
A
H
P
S
P
R
S
V
Y
R
G
F
F
G
C
R
H
F
S
K
T
N
E
L
L
Q
K
S
G
K
K
P
I
D
W
K
-----
51
PsiBlast_CBE
74.56
46%
-11
- C8 -
-
4WRU
2
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
42
PsiBlast_CBE
74.44
46%
-16
- C8 -
-
4WS3
2
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
44
PsiBlast_CBE
74.20
46%
-14
- C8 -
-
4WS1
8
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
37
PsiBlast_CBE
74.20
46%
-12
- C8 -
-
4WS8
1
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
59
PsiBlast_CBE
73.77
37%
-31
- C8 -
-
1UDH
1
UNG_HHV11
A:
[27-244]
------
L
I
D
D
A
W
R
P
L
M
E
P
E
L
A
N
P
L
T
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
D
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
R
A
N
-
V
P
P
-
P
P
S
L
R
N
V
---
L
A
A
V
K
N
C
Y
P
E
A
-
R
-
M
S
--
G
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
I
G
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
P
-
D
P
R
V
H
C
V
L
K
F
S
H
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
----
45
PsiBlast_CBE
73.71
46%
-11
- C8 -
-
4WS0
7
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
50
PsiBlast_CBE
73.70
46%
-15
- C8 -
-
4WRV
1
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
49
PsiBlast_CBE
73.65
46%
-10
- C8 -
-
4WRW
4
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
47
PsiBlast_CBE
73.22
46%
-7
- C8 -
-
4WRY
2
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
38
PsiBlast_CBE
73.22
46%
-8
- C8 -
-
4WS7
2
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
40
PsiBlast_CBE
72.92
46%
-8
- C8 -
-
4WS5
1
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
61
PsiBlast_CBE
72.71
37%
-27
- C8 -
-
1LAU
1
UNG_HHV11
E:
[27-244]
------
L
I
D
D
A
W
R
P
L
M
E
P
E
L
A
N
P
L
T
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
D
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
R
A
N
-
V
P
P
-
P
P
S
L
R
N
V
---
L
AAV
K
N
C
Y
P
E
A
-
R
-
M
S
--
G
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
I
G
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
P
-
D
P
R
V
H
C
V
L
K
F
S
H
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
----
52
PsiBlast_CBE
72.65
46%
-3
- C8 -
-
4WPL
9
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
46
PsiBlast_CBE
71.87
46%
-3
- C8 -
-
4WRZ
3
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
53
PsiBlast_CBE
71.67
46%
-3
- C8 -
-
4WPK
1
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
41
PsiBlast_CBE
71.62
46%
-3
- C8 -
-
4WS4
8
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
43
PsiBlast_CBE
71.47
46%
-3
- C8 -
-
4WS2
9
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
39
PsiBlast_CBE
71.44
46%
-2
- C8 -
-
4WS6
8
UNG_MYCTU
A:
[17-238]
---
L
S
E
L
V
E
R
G
W
A
A
A
L
--
E
P
V
A
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
-
A
G
-
R
R
Y
L
P
A
G
S
N
V
L
R
A
F
T
F
-
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
-
V
R
P
W
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
P
---
85
HHSearch
71.37
46%
-1
- C8 -
-
4WPK
1
UNG_MYCTU
A:
[16-237]
--
P
L
S
E
L
V
E
R
G
W
A
A
A
L
E
P
V
A
--
D
Q
V
A
H
M
G
Q
F
L
R
A
E
I
A
A
G
R
-
R
Y
L
-
P
A
G
S
N
V
L
R
A
F
T
-
F
P
F
D
N
V
R
V
L
I
V
G
Q
D
P
Y
P
T
P
G
H
A
V
G
L
S
F
S
V
A
P
D
V
R
P
W
-
P
R
S
L
A
N
I
---
F
---
D
E
Y
T
A
D
L
-
G
-
Y
P
L
P
S
N
G
D
L
T
P
W
A
Q
R
G
V
L
L
L
N
R
V
L
T
V
R
P
S
N
P
A
S
H
R
G
K
G
W
E
A
V
T
E
C
A
I
R
A
L
A
A
R
A
A
P
L
V
A
I
L
W
G
R
D
A
S
T
L
K
P
M
L
A
A
G
N
C
V
A
I
E
S
P
H
P
S
P
L
S
A
S
R
G
F
F
G
S
R
P
F
S
R
A
N
E
L
L
V
G
M
G
A
E
P
I
D
W
R
L
----
33
PsiBlast_CBE
71.36
51%
3
- C8 -
-
2EUG
1
UNG_ECOLI
A:
[6-220]
----------
T
W
H
D
V
L
A
E
E
K
Q
Q
P
H
F
L
N
T
L
Q
T
V
A
S
E
R
Q
-
S
G
V
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
R
P
G
-
I
A
I
-
P
P
S
L
L
N
M
---
Y
---
K
E
L
E
N
T
I
P
G
-
F
T
R
P
N
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
L
G
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
------
32
PsiBlast_CBE
71.27
51%
4
- C8 -
-
3EUG
2
UNG_ECOLI
A:
[6-220]
----------
T
W
H
D
V
L
A
E
E
K
Q
Q
P
H
F
L
N
T
L
Q
T
V
A
S
E
R
Q
-
S
G
V
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
R
P
G
-
I
A
I
-
P
P
S
L
L
N
M
---
Y
---
K
E
L
E
N
T
I
P
G
-
F
T
R
P
N
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
L
G
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
------
35
PsiBlast_CBE
71.20
51%
11
- C8 -
-
5EUG
1
UNG_ECOLI
A:
[6-220]
----------
T
W
H
D
V
L
A
E
E
K
Q
Q
P
Y
F
L
N
T
L
Q
T
V
A
S
E
R
Q
-
S
G
V
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
R
P
G
-
I
A
I
-
P
P
S
L
L
N
M
---
Y
---
K
E
L
E
N
T
I
P
G
-
F
T
R
P
N
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
L
G
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
Q
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
------
63
PsiBlast_CBE
70.74
36%
-26
- C8 -
-
2C53
5
UNG_HHV11
A:
[27-244]
------
L
I
D
D
A
W
R
P
L
M
E
P
E
L
A
N
P
L
T
A
H
L
L
A
E
Y
N
R
R
C
Q
-
T
E
-
E
V
L
-
P
P
R
E
D
V
F
S
W
T
R
Y
C
T
P
D
E
V
R
V
V
I
I
G
Q
N
P
Y
H
H
P
G
Q
A
H
G
L
A
F
S
V
R
A
N
-
V
P
P
-
P
P
S
L
R
N
V
L
A
A
V
---
K
N
C
Y
P
E
A
-
R
-
M
S
--
G
H
G
C
L
E
K
W
A
R
D
G
V
L
L
L
N
T
T
L
T
V
K
R
G
A
A
A
S
H
S
R
I
G
W
D
R
F
V
G
G
V
I
R
R
L
A
A
R
R
P
G
L
V
F
M
L
W
G
T
H
A
Q
N
A
I
R
P
-
D
P
R
V
H
C
V
L
K
F
S
N
P
S
P
L
S
K
V
-
P
F
G
T
C
Q
H
F
L
V
A
N
R
Y
L
E
T
R
S
I
S
P
I
D
W
S
V
----
34
PsiBlast_CBE
69.04
51%
2
- C8 -
-
1FLZ
1
UNG_ECOLI
A:
[5-219]
----------
T
W
H
D
V
L
A
E
E
K
Q
Q
P
H
F
L
N
T
L
Q
T
V
A
S
E
R
Q
-
S
G
V
T
I
Y
-
P
P
Q
K
D
V
F
N
A
F
R
F
T
E
L
G
D
V
K
V
V
I
L
G
Q
D
P
Y
H
G
P
G
Q
A
H
G
L
A
F
S
V
R
P
G
-
I
A
I
-
P
P
S
L
L
N
M
---
Y
---
K
E
L
E
N
T
I
P
G
-
F
T
R
P
N
H
G
Y
L
E
S
W
A
R
Q
G
V
L
L
L
N
T
V
L
T
V
R
A
G
Q
A
H
S
H
A
S
L
G
W
E
T
F
T
D
K
V
I
S
L
I
N
Q
H
R
E
G
V
V
F
L
L
W
G
S
H
A
Q
K
K
G
A
I
I
D
K
Q
R
H
H
V
L
K
A
P
H
P
S
P
L
S
A
H
R
G
F
F
G
C
N
H
F
V
L
A
N
Q
W
L
E
Q
H
G
E
T
P
I
D
W
------