@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0054: (2016-03-11 )
VDNNFQDRTPPQNIEAEQAVLGAIFLEPNALITASEILMPDDFYRTGHQIIFETMLDLNDHGKAVDVLTVYEALAAKGNLEDAGGLPYLTELSGAVPTAANLEYYAHIIEDKALLRRLIRTATQIATDGYSREDELDMLMDEAEKSILEVSQRKNVGAFKNIKDVLVKTYDDIEILHNRKGDITGIPTGFNELDKMTAGFQRNDLIIVAARPSVGKTAFALNIAQNVATKTDENVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGALTSDDWQKLTIAMGTLSNSGIYIDDTPGVRVNEIRSKCRRLKQETGLGMIVIDYLQLIAGSGRGGENRQQEVSEISRSLKALARELEVPVIALSQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYREDYYDREGENDGTIEIIIAKQRNGPVGDVKLAFVKEYNKFVNLEVRYDDAMA
Atome Classification :
(23 SA)
.........10........20........30.......-.-40........50.......-.60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180-.---.......190.......200.......210.......220.......230.......240.......250.......260....--...270.......280.......290.......300.......-310--.......320....--...330.......340.......350.......360.......370.......380.......390.......400...--...-------------------------------.410---.......420.......430.......440.......450
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
VDNNFQDRTPPQN
I
E
A
E
Q
A
V
L
G
A
I
F
LEPN
A
L
I
T
A
S
EIL-M-P
D
D
F
Y
R
T
G
H
Q
I
I
F
E
T
M
LDL-NDHGK
A
V
D
V
L
T
V
Y
E
A
L
A
AKGNLEDAGGL
P
Y
L
T
E
LSGAVPTA
A
N
L
E
Y
Y
A
H
I
IE
D
K
A
L
L
R
R
L
I
R
T
A
T
Q
IATDGYS
R
E
D
E
L
D
M
L
M
D
E
A
E
K
S
I
L
E
V
S
Q
RKNVG
A
F
K
N
I
K
D
V
L
V
K
TYD
D
I
E
I
L
HNRKG--D---ITGIPT
G
F
N
E
L
D
K
M
T
AGFQRN
D
L
I
I
V
AARPSVGK
T
A
F
A
L
N
I
A
Q
N
VATKTDE
N
V
A
I
F
S
LEM
G
A
E
Q
L
V
M
R
M
L
CAEGNI
N
A
Q
NLRTG--ALTSDD
W
Q
K
L
T
I
A
M
GTLSNS
G
I
Y
IDDTPGV
R
V
N
E
I
R
S
K
C
R
R
L
K
-
Q
ET--GL
G
M
I
V
I
D
Y
L
Q
L
I
A--GSGRGG
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
LEV
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
QDKR
P
M
M
S
D
I
R
ESGSIEQ
D
A
D
I
V
A
F
L
Y
REDYYDRE--GEN-------------------------------D
G
T
I
---
E
I
I
I
A
KQRNGPVG
D
V
K
L
A
F
V
K
E
Y
N
K
F
V
N
L
E
V
R
YDDAMA
28
PsiBlast_CBE
94.27
77%
-112
- C4 -
4ESV
4
?
C:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
--
E
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
3
PsiBlast_PDB
93.63
77%
-114
- C4 -
4ESV
8
?
A:
[6-441]
-----
S
E
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
------
F
K
N
I
K
D
I
L
V
Q
T
Y
-----------------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
27
PsiBlast_CBE
93.57
77%
-111
- C4 -
4ESV
1
?
D:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
--
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
25
PsiBlast_CBE
93.40
77%
-113
- C4 -
4ESV
1
?
G:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
-------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
29
PsiBlast_CBE
93.03
77%
-114
- C4 -
4ESV
3
?
B:
[6-445]
-----
S
E
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
--
G
--
E
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
--------
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
-----
24
PsiBlast_CBE
92.89
77%
-112
- C4 -
4ESV
2
?
H:
[9-445]
--------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
---------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
--------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
E
R
R
F
-----
23
PsiBlast_CBE
92.51
77%
-114
- C4 -
4ESV
27
?
I:
[9-441]
--------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
---------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
26
PsiBlast_CBE
92.14
77%
-112
- C4 -
4ESV
4
?
F:
[9-441]
--------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
22
PsiBlast_CBE
92.10
77%
-115
- C4 -
4ESV
26
?
J:
[14-441]
-------------
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
------
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
49
HHSearch
92.08
78%
-119
- C4 -
2R6A
2
?
A:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
--
E
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
1
PsiBlast_PDB
91.75
77%
-119
- C4 -
2R6A
2
?
A:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
D
G
--
E
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
21
PsiBlast_CBE
91.58
77%
-110
- C4 -
4ESV
1
?
L:
[10-441]
---------
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
-------
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
M
L
-----------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
S
K
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
K
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
Y
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
30
PsiBlast_CBE
91.49
77%
-125
- C4 -
2R6E
1
?
B:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
--------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
2
PsiBlast_PDB
90.56
77%
-125
- C4 -
2R6E
1
?
A:
[8-441]
-------
R
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
--------------------------------------
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
----
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
---
R
P
M
M
S
D
I
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
Y
----------------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
4
PsiBlast_PDB
89.21
77%
-101
- C- -
2VYE
1
?
A:
[9-441]
--------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
T
A
L
T
L
A
S
E
R
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
K
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
L
E
Q
L
E
E
V
G
G
V
S
Y
L
S
E
L
A
D
S
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
L
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
E
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
V
L
V
Q
T
Y
D
N
I
E
M
L
H
N
R
N
G
--
D
---
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
V
V
I
D
Y
L
Q
L
I
Q
--
G
S
G
R
N
R
E
N
R
Q
Q
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
S
R
S
V
E
Q
R
Q
D
--
P
M
M
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
I
V
A
F
L
Y
R
D
D
--
N
K
D
--
S
E
N
-------------------------------
K
N
I
I
---
E
I
I
I
A
K
Q
R
N
G
----
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
31
PsiBlast_CBE
86.78
77%
-126
- C4 -
2R6A
2
?
B:
[9-441]
--------
I
P
P
Q
S
I
E
A
E
Q
A
V
L
G
A
V
F
L
D
P
A
A
L
V
P
A
S
E
I
L
-
I
-
P
E
D
F
Y
R
A
A
H
Q
K
I
F
H
A
M
L
R
V
-
A
D
R
G
E
P
V
D
L
V
T
V
T
A
E
L
A
A
S
E
Q
L
E
E
I
G
G
V
S
Y
L
S
E
L
A
D
A
V
P
T
A
A
N
V
E
Y
Y
A
R
I
V
E
E
K
S
V
L
R
R
L
I
R
T
A
T
S
I
A
Q
D
G
Y
T
R
E
D
E
I
D
V
L
L
D
E
A
D
R
K
I
M
E
V
S
Q
R
K
H
S
G
A
F
K
N
I
K
D
I
L
V
Q
T
Y
D
N
I
E
-------------
I
T
G
I
P
T
G
F
T
E
L
D
R
M
T
S
G
F
Q
R
S
D
L
I
I
V
A
A
R
P
S
V
G
K
T
A
F
A
L
N
I
A
Q
N
V
A
T
K
T
N
E
N
V
A
I
F
S
L
E
M
S
A
Q
Q
L
V
M
R
M
L
C
A
E
G
N
I
N
A
Q
N
L
R
T
G
--
K
L
T
P
E
D
W
G
K
L
T
M
A
M
G
S
L
S
N
A
G
I
Y
I
D
D
T
P
S
I
R
V
S
D
I
R
A
K
C
R
R
L
K
-
Q
E
S
--
G
L
G
M
I
V
I
D
Y
L
Q
L
I
--------------
E
V
S
E
I
S
R
S
L
K
A
L
A
R
E
L
E
V
P
V
I
A
L
S
Q
L
-------------------------
D
A
D
I
V
A
F
L
-----------------------------------------------
I
I
---
E
I
I
I
A
K
Q
R
N
G
P
V
G
T
V
Q
L
A
F
I
K
E
Y
N
K
F
V
N
L
---------
35
PsiBlast_CBE
80.91
47%
-103
- C4 -
2Q6T
1
?
B:
[6-440]
---------
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
-
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
-
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
------
A
R
P
M
R
E
L
V
H
E
T
F
E
H
I
E
A
L
--------------
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
-----
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
-
S
Q
N
--
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
GP-------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
--
S
E
K
-------------------------------
A
G
I
A
---
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
---------
33
PsiBlast_CBE
78.61
47%
-107
- C4 -
2Q6T
1
?
D:
[6-440]
---------
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
P
S
-
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
-
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
--
T
E
A
R
P
M
R
E
L
V
H
E
T
F
E
H
I
E
A
L
F
---------------
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
-----------------
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
-
S
Q
N
--
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
G--------
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
--
S
E
K
-------------------------------
A
G
I
A
---
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
---------
39
Fugue
78.19
47%
-95
- C4 -
2Q6T
1
?
A:
[5-440]
--------
I
P
P
H
S
L
E
A
E
Q
S
V
L
G
S
I
L
L
D
S
D
V
M
D
E
V
E
G
L
L
-
P
S
P
E
A
F
Y
A
E
A
H
R
K
I
Y
A
A
M
Q
A
L
-
R
S
Q
G
R
P
V
D
L
V
T
L
S
E
E
L
S
R
R
G
Q
L
E
E
V
G
G
T
A
Y
L
L
Q
L
S
E
A
T
P
T
A
A
Y
A
E
H
Y
A
R
I
V
A
E
K
W
T
L
R
R
L
I
Q
A
A
G
E
A
M
R
L
A
Y
E
E
A
G
S
L
D
E
I
L
D
T
A
G
K
K
I
L
E
V
A
L
T
K
T
D
T
E
A
R
P
M
R
E
L
V
H
E
T
F
E
H
I
E
---------------
A
V
R
T
G
F
K
E
L
D
Q
L
I
G
T
L
G
P
G
S
L
N
I
I
A
A
R
P
A
M
G
K
T
A
F
A
L
T
I
A
Q
N
A
A
L
K
E
G
V
G
V
G
I
Y
S
L
E
M
P
A
A
Q
L
T
L
R
M
M
C
S
E
A
R
I
D
M
N
R
V
R
L
G
--
Q
L
T
D
R
D
F
S
R
L
V
D
V
A
S
R
L
S
E
A
P
I
Y
I
D
D
T
P
D
L
T
L
M
E
V
R
A
R
A
R
R
L
V
-
S
Q
N
--
Q
V
G
L
I
I
I
D
Y
L
Q
L
M
S
--
G
-----
P
N
R
Q
Q
E
I
A
A
I
S
R
G
L
K
A
L
A
R
E
L
G
I
P
I
I
A
L
S
Q
L
S
R
A
V
E
A
R
P
N
K
R
P
M
L
S
D
L
R
E
S
G
S
I
E
Q
D
A
D
L
V
M
F
I
Y
R
D
E
Y
Y
N
P
H
--
S
E
K
-------------------------------
A
G
I
A
---
E
I
I
V
G
K
Q
R
N
G
P
T
G
T
V
E
L
Q
F
H
A
S
H
V
R
F
N
D
L
---------
50
HHSearch
78.12
45%
-97
* C4 *
3BGW
-
?
A:
[12-436]
------------
N
E
Y
A
E
Q
A
V
L
G
S
I
L
T
E
P
E
L
I
K
E
C
--
P
L
-
T
-
P
E
H
F
S
P
G
K
H
F
N
I
Y
F
T
M
Q
D
L
-
D
R
K
G
Q
S
V
D
F
T
S
I
A
A
R
V
G
E
K
--
L
P
Q
L
G
G
F
G
Y
L
T
E
L
A
A
S
V
A
S
T
T
T
F
K
Q
H
C
Q
T
V
S
E
Y
F
Q
K
R
K
A
I
S
I
A
Q
Q
I
I
E
N
V
N
------
V
K
P
I
Q
E
A
V
S
E
L
M
E
I
E
A
S
G
T
D
D
D
D
G
S
I
D
E
A
L
V
T
V
Y
E
E
I
E
S
---
A
D
G
--
N
---
I
T
G
V
P
S
G
F
T
E
L
D
R
M
T
Y
G
Y
K
R
R
N
F
V
L
I
A
A
R
P
S
M
G
K
T
A
F
A
L
K
Q
A
K
N
M
S
D
N
-
D
D
V
V
N
L
H
S
L
E
M
G
K
K
E
N
I
K
R
L
I
V
T
A
G
S
I
N
A
Q
K
I
K
A
A
RR
D
F
A
S
E
D
W
G
K
L
S
M
A
I
G
E
I
S
N
S
N
I
N
I
F
D
K
A
G
Q
S
V
N
Y
I
W
S
K
T
R
Q
T
K
-
R
K
N
PG
K
R
V
I
V
M
I
D
Y
L
Q
L
L
E
--
P
A
K
A
-
N
D
S
R
T
N
Q
I
S
Q
I
S
R
D
L
K
K
M
A
R
E
L
D
V
V
V
I
A
L
S
Q
L
S
R
Q
V
E
Q
R
Q
D
K
R
P
M
L
S
D
L
R
E
S
G
Q
L
E
Q
D
A
D
I
I
E
F
L
Y
R
D
D
Y
Y
D
K
E
--
S
E
S
-------------------------------
K
N
I
V
---
E
V
I
I
A
K
H
R
D
G
P
V
G
T
V
S
L
A
F
I
K
E
Y
G
N
F
V
N
L
E
--------
8
PsiBlast_PDB
74.63
39%
-101
- C4 -
4NMN
3
?
A:
[2-433]
----------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
-
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
Y
G
N
K
L
D
F
V
L
I
K
D
H
L
E
-
K
K
N
L
L
Q
---
I
D
W
L
E
E
L
Y
E
E
A
V
S
P
D
T
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
-
F
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
--
S
T
Q
F
Y
H
V
K
D
V
---
A
E
E
V
I
E
L
I
Y
K
F
K
S
--
S
DRL
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
--
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
-
K
E
K
--
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
--
P
P
V
R
K
S
-
P
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
R
E
V
E
K
R
S
D
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
K
K
PN--
E
-------------------------------
Q
G
I
A
---
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
E
--------
36
PsiBlast_CBE
72.62
39%
-94
- C4 -
4NMN
3
?
B:
[2-432]
----------
P
C
D
E
S
A
E
R
A
V
L
G
S
M
L
E
D
P
E
N
I
P
L
V
L
E
Y
L
-
K
-
E
E
D
F
C
I
D
E
H
K
L
L
F
R
V
L
T
N
L
W
S
E
-
G
N
K
L
D
F
V
L
I
K
D
H
L
E
-
K
K
------
P
I
D
W
L
E
E
L
Y
E
E
A
V
S
P
D
T
L
E
E
V
C
K
I
V
K
Q
R
S
A
Q
R
A
I
I
Q
L
G
I
E
L
I
H
K
G
K
E
N
K
D
-
F
H
T
L
I
E
E
A
Q
S
R
I
F
S
I
A
E
S
A
T
S
T
Q
F
Y
H
V
K
D
V
---
A
E
E
V
I
E
L
I
Y
K
F
K
S
--
S
DRL
V
T
G
L
P
S
G
F
T
E
L
D
L
K
T
T
G
F
H
P
G
D
L
I
I
L
A
A
R
P
G
M
G
K
T
A
F
M
L
S
I
I
Y
N
L
A
K
D
E
G
K
P
S
A
V
F
S
L
E
M
S
K
E
Q
L
V
M
R
L
L
S
M
M
S
E
V
P
L
F
K
I
R
S
G
--
S
I
S
N
E
D
L
K
K
L
E
A
S
A
I
E
L
A
K
Y
D
I
Y
L
D
D
T
P
A
L
T
T
T
D
L
R
I
R
A
R
K
L
R
-
K
E
K
--
E
V
E
F
V
A
V
D
Y
L
Q
L
L
R
--
P
P
V
R
K
S
-
P
R
Q
E
E
V
A
E
V
S
R
N
L
K
A
L
A
K
E
L
R
I
P
V
M
A
L
A
Q
L
S
--------
K
R
P
Q
L
A
D
L
R
E
S
G
Q
I
E
Q
D
A
D
L
I
L
F
L
H
R
P
E
Y
Y
T
----
P
E
E
-------------------------------
Q
G
I
A
---
E
V
I
I
A
K
Q
R
Q
G
P
T
D
I
V
K
L
A
F
I
K
E
Y
T
K
F
A
N
L
---------
10
PsiBlast_PDB
65.84
42%
-90
- C4 -
4A1F
2
?
A:
[2-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
I
K
E
V
L
E
S
A
M
D
L
I
-
T
E
N
Q
R
K
G
SL
E
---
V
T
G
I
P
T
G
F
V
Q
L
D
N
Y
T
S
G
F
N
K
G
S
L
V
I
I
G
A
R
P
S
M
G
K
T
S
L
M
M
N
M
V
L
S
-
A
L
N
D
D
R
G
V
A
V
F
S
L
E
M
S
A
E
Q
L
A
L
R
A
L
S
D
L
T
S
I
N
M
H
D
L
E
S
G
--
R
L
D
D
D
Q
W
E
N
L
A
K
C
F
D
H
L
S
Q
K
K
L
F
F
Y
D
K
S
Y
V
R
I
E
Q
I
R
L
Q
L
R
K
L
K
S
Q
H
K
--
E
L
G
I
A
F
I
D
Y
L
Q
L
M
S
--
G
S
-
K
A
T
K
E
R
H
E
Q
I
A
E
I
S
R
E
L
K
T
L
A
R
E
L
E
I
P
I
I
A
L
V
Q
L
N
R
S
L
E
N
R
D
D
K
R
P
I
L
S
D
I
K
D
S
G
G
I
E
Q
D
A
D
I
V
L
F
L
Y
R
G
Y
I
Y
Q
M
R
--
A
E
D
N
K
I
D
K
L
K
K
EGK
I
E
E
A
Q
E
L
Y
L
K
V
N
E
E
R
R
I
H
K
Q
N
G
S
I
E
E
A
E
I
I
V
A
K
N
R
N
G
A
T
G
T
V
Y
T
R
F
N
A
P
F
T
R
Y
E
D
M
P
I
-------