@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0154: (2016-03-12 )
MKYIDIANIGFKYESEPVLENISFQVSAGEFIILTGENGAAKSTLLRIILGILQPDKGSVTFAKKNADGGRLLTGYVPQQIASFNAGFPSTVLELVRSGRFPNGKWFKRLTTKDHAHVEKALKSVEMWDYRHKRIGELSGGQKQRICLARMFATDPDILILDEPQTAMDKQSKIRFYNLLKHEAQVHGKAILMVTHDSEEMEDFVDKHIRLIRKEDVSWKCFSMDLCKEPSKRP
Atome Classification :
(29 SA)
-.........10...----.----.--.-..-20........30........40........50........60--.....-------.-----.--------.------------------.---------70.---.------..----..--..80...-----..--------...90.........100......-.110...----------------....120.......----130-----.-......----..140.......150..------.....160.......170.......180....-...190.......200.......210.......220.......230..--------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-M
K
Y
I
D
IANIGFKYE----S----E--P-
V
L
-EN
I
S
F
Q
VSAG
E
F
I
I
L
TGENG
A
A
K
S
T
L
L
R
I
I
L
G
I
LQPDKG
S
V
---
T
F
A
KK-------N-----A--------D------------------G---------
G
R
L
---
L
------
T
G
----
Y
V
--
P
Q
Q
I
A
SF-----NA--------G
F
P
S
-
T
V
L
E
L
V
RSGRFPN
G
K
W
F
K
-
R
LTTK
D
H
----------------
A
H
V
E
K
A
L
K
S
V
E
M
W
D
----
Y
-------
R
-
H
K
R
IGE----LSGGQ
K
Q
R
I
C
L
A
R
M
FAT------DP
D
I
L
I
LDEPQTAM
D
K
Q
S
K
I
R
F
Y
N
L
L
K
H
E
A
QV-H
G
K
A
I
L
M
V
TH
D
S
E
E
M
E
D
F
V
D
K
H
I
R
L
I
RKEDV
S
W
K
C
F
S
M
D
L
CKEPSKRP--------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.12
28%
-97
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-236]
----
L
H
I
G
H
L
S
K
S
F
Q
----
N
----
T
--
P
-
V
L
-
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
---
S
L
S
G
K
TIFSKN
T
N
-----
L
--------
P
------------------
V
---------
R
E
R
---
R
------
L
G
----
Y
L
--
V
Q
E
---------
G
V
--------
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
-
L
G
N
G
K
G
R
----
T
A
Q
E
R
----------------
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
----
L
-------
A
-
G
R
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
-
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
-----------------------------------------------------------------------------------------------------------------------
55
HHSearch
87.75
28%
-108
- C1 -
2IHY
1
?
A:
[20-252]
--
M
L
I
Q
L
D
Q
I
G
R
M
K
Q
----
G
----
K
--
T
-
I
L
-
K
K
I
S
W
Q
I
A
K
G
D
K
W
I
L
Y
G
L
N
G
A
G
K
T
T
L
L
N
I
L
N
A
Y
E
P
A
T
S
G
T
V
---
N
L
F
G
K
-------
M
-----
P
GYS
A
----
E
------------------
T
---------
V
R
Q
---
H
------
I
G
----
F
V
--
S
H
S
L
-
L
E
-----
K
F
--------
Q
E
G
E
-
R
V
I
D
V
V
I
S
G
A
----------
I
D
D
E
I
R
----------------
N
E
A
H
Q
L
L
K
L
V
G
M
S
A
----
K
-------
A
-
Q
Q
Y
I
G
Y
----
L
S
T
G
E
K
Q
R
V
M
I
A
R
A
L
M
G
------
Q
P
Q
V
L
I
L
D
E
P
A
A
G
L
D
F
I
A
R
E
S
L
L
S
I
L
D
S
L
S
D
S
Y
P
T
L
A
M
I
Y
V
T
H
F
I
E
E
I
T
A
N
F
S
K
I
L
L
L
K
D
G
Q
S
I
Q
Q
G
-
A
V
E
D
I
L
T
--------------------------------------------------------------------------------------------------------------------------
52
HHSearch
83.94
26%
-100
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-234]
-
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
S
D---
G
----
T
--
H
-
A
L
-
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
---
L
F
D
N
K
-------
P
-----
I
--------
D
YS
R
K
G
I
M
-----------
K
---------
L
R
E
---
S
------
I
G
----
I
V
--
F
Q
D
P
D
N
Q
---------------
L
F
S
A
-
S
V
Y
Q
D
V
S
F
G
A
V
N
M
K
L
P
-----
E
D
E
I
R
----------------
K
R
V
D
N
A
L
K
R
T
G
I
E
H
----
L
-------
K
-
D
K
P
T
H
C
----
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
-
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
Q
G
-
N
P
K
E
V
F
A
E
-------------------------------------------------------------------------------------------------------------------------
53
HHSearch
82.73
27%
-94
- C1 -
2OLJ
4
?
A:
[22-251]
-
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
----
L
--
E
-
V
L
-
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
---
I
I
D
G
I
-------
N
-----
L
--------
K
AKDTN
L
N
-----------
K
---------
V
R
E
---
E
------
V
G
----
M
V
--
F
Q
R
F
N
L
F
-----
P
-----------
H
M
-
T
V
L
N
N
I
T
L
A
P
M
K
V
R
K
W
P
----
R
E
K
A
E
----------------
A
K
A
M
E
L
L
D
K
V
G
L
K
D
----
K
-------
A
-
H
A
Y
P
D
S
----
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
--
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
-
K
P
E
D
L
F
D
R
P
Q
-----------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.30
28%
-111
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[3-209]
--
K
A
L
S
V
E
N
L
G
F
Y
Y
Q
----
A
----
E
--
N
-
F
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
---
E
V
Y
Q
S
----------------------------------------------------------------
I
G
----
F
V
--
P
Q
---
F
F
-----
S
S
--------
P
F
A
Y
-
S
V
L
D
I
V
L
M
G
R
S
T
H
I
N
T
F
A
-
K
P
K
S
H
D
Y
----------------
Q
V
A
M
Q
A
L
D
Y
L
N
L
T
H
----
L
-------
A
-
K
R
E
F
T
S
----
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
-
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
L
-
L
L
N
K
Q
N
F
K
F
-----------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
81.48
29%
-90
- C1 -
1Z47
1
?
A:
[13-238]
--
M
T
I
E
F
V
G
V
E
K
I
Y
P
G---
G
----
A
--
R
-
S
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
---
W
I
G
G
K
-------
R
-----
V
--------
T
DLP---------------
P
---------
Q
K
R
---
N
------
V
G
----
L
V
--
F
Q
N
Y
A
L
F
----------------
Q
H
M
-
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
P
-----
K
D
E
M
D
----------------
A
R
V
R
E
L
L
R
F
M
R
L
E
S
----
Y
-------
A
-
N
R
F
P
H
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
-
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
-
T
P
E
E
V
Y
E
K
P
G
-----------------------------------------------------------------------------------------------------------------------
57
HHSearch
81.21
26%
-94
- C1 -
1B0U
4
HISP_SALTY
A:
[5-243]
--
N
K
L
H
V
I
D
L
H
K
R
Y
G
----
G
----
H
--
E
-
V
L
-
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
---
I
V
N
G
Q
-------
N
-----
I
--------
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
---------
L
R
T
---
R
------
L
T
----
M
V
--
F
Q
H
F
N
L
W
----------------
S
H
M
-
T
V
L
E
N
V
M
E
A
P
I
Q
V
L
G
L
----
S
K
H
D
A
R
----------------
E
R
A
L
K
Y
L
A
K
V
G
I
D
E
----
R
-------
A
Q
G
K
Y
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
--
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
E
G
-
D
P
E
Q
V
F
G
N
-------------------------------------------------------------------------------------------------------------------------
45
HHSearch
79.88
26%
-87
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
GTRT
I
--
Q
-
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
-------
E
-----
L
--------
T
TLSESELT----------
K
---------
A
R
R
---
Q
------
I
G
----
M
I
--
F
Q
H
F
N
L
L
-----
S
-----------
S
R
-
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
P
-----
K
D
E
V
K
----------------
R
R
V
T
E
L
L
S
L
V
G
L
G
D
----
K
-------
H
-
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
-
T
V
S
E
V
F
S
H
P
------------------------------------------------------------------------------------------------------------------------
63
Fugue
79.82
26%
-86
- C1 -
1Z47
1
?
A:
[11-355]
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
----
G
----
G
--
A
R
S
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
---
W
I
G
G
K
-------
R
-----
V
--------
T
------------------
D
---------
L
P
P
---
Q
------
K
R
----
N
V
--
G
L
V
F
Q
N
Y
-----
A
L
--------
F
Q
H
M
-
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
V
-----
P
K
D
E
M
D
----------------
A
R
V
R
E
L
L
R
F
M
R
L
E
S
----
Y
-------
A
-
N
R
F
P
H
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
-
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
-
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
IGE
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R--
6
PsiBlast_PDB
79.07
32%
-109
- C1 -
4HUQ
-
ECFA1_LACBA
B:
[6-203]
----
I
S
V
D
H
L
T
Y
Q
Y
D
----
E
----
N
Q
A
P
-
A
L
-
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
---
T
V
--------------------------------------------
G
---------
G
I
T
---
L
------
T
P
ET
V
W
Q
V
--
R
E
Q
I
G
M
I
F
Q
NPD
N
Q
--------
F
V
G
A
-
T
V
E
D
D
V
A
F
G
------
L
E
N
-
R
Q
I
S
R
D
E
M
V
--------------
P
R
V
Q
A
A
L
A
Q
V
G
M
T
S
----
F
-------
A
-
Q
R
E
P
S
S
----
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
------
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
I
V
R
Q
L
R
Q
Q
-
Q
N
L
T
V
I
S
I
T
H
D
I
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.80
32%
-111
- C1 -
4HZU
-
ECFA1_LACBA
A:
[6-203]
----
I
S
V
D
H
L
T
Y
Q
Y
-----------Q
A
P
-
A
L
-
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
---
T
V
--------------------------------------------
G
---------
G
I
T
---
L
------
T
P
ET
V
W
Q
V
--
R
E
Q
I
G
M
I
F
Q
NPD
N
Q
--------
F
V
G
A
-
T
V
E
D
D
V
A
F
G
------
L
E
N
-
R
Q
I
S
R
D
E
M
V
--------------
P
R
V
Q
A
A
L
A
Q
V
G
M
T
S
----
F
-------
A
-
Q
R
E
P
S
S
----
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
------
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
I
V
R
Q
L
R
Q
Q
-
Q
N
L
T
V
I
S
I
T
H
D
I
D
E
------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
77.55
26%
-84
- C1 -
1OXX
21
?
K:
[1-233]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
K
----
K
GK--
V
--
V
-
A
L
-
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
---
Y
F
D
D
R
-------
L
-----
V
--------
A
SNGKLIVP----------
P
---------
E
D
R
---
K
------
I
G
----
M
V
--
F
Q
T
W
A
L
Y
----------------
P
N
L
-
T
A
F
E
N
I
A
F
P
L
T
N
M
K
M
-----
S
K
E
E
I
R
----------------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
----
V
-------
L
-
N
H
F
P
R
E
----
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
------
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
-
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
-
K
P
E
D
L
Y
D
N
P
V
-----------------------------------------------------------------------------------------------------------------------
39
HHSearch
77.35
27%
-84
- C1 -
2IT1
-
?
A:
[1-226]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
G
----
N
----
F
--
T
-
A
L
-
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
---
Y
F
D
E
K
-------
D
-----
V
--------
T
ELP---------------
P
---------
K
D
R
---
N
------
V
G
----
L
V
--
F
Q
N
W
A
L
Y
-----
P
-----------
H
M
-
T
V
Y
K
N
I
A
F
P
L
E
L
R
K
A
P
-----
R
E
E
I
D
----------------
K
K
V
R
E
V
A
K
M
L
H
I
D
K
----
L
-------
L
-
N
R
Y
P
W
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
-
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
-
T
P
D
E
V
Y
Y
K
P
K
-----------------------------------------------------------------------------------------------------------------------
58
HHSearch
76.19
28%
-87
- C1 -
2PCJ
-
LOLD_AQUAE
A:
[2-221]
-
A
E
I
L
R
A
E
N
I
K
K
V
I
R
----
G
----
Y
--
E
-
I
L
-
K
G
I
S
L
S
V
K
K
G
E
F
V
S
I
I
G
A
S
G
S
G
K
S
T
L
L
Y
I
L
G
L
L
D
A
P
T
E
G
K
V
---
F
L
E
G
K
-------
E
-----
V
--------
D
------------------
Y
TN
E
K
E
L
S
L
L
R
N
R
---
K
------
L
G
----
F
V
--
F
Q
F
H
Y
L
I
-----
P
-----------
E
L
-
T
A
L
E
N
V
I
V
P
M
L
K
M
G
K
-----
P
K
K
E
A
K
----------------
E
R
G
E
Y
L
L
S
E
L
G
L
G
D
----
K
-------
L
-
S
R
K
P
Y
E
----
L
S
G
G
E
Q
Q
R
V
A
I
A
R
A
L
A
N
------
E
P
I
L
L
F
A
D
E
P
T
G
N
L
D
S
A
N
T
K
R
V
M
D
I
F
L
K
I
N
-
E
-
G
G
T
S
I
V
M
V
T
H
E
R
E
L
A
-
E
L
T
H
R
T
L
E
M
K
D
G
K
V
V
G
E
I
----------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
75.66
28%
-92
- C- -
3FVQ
3
FBPC_NEIG1
A:
[2-236]
-
T
A
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
----
T
--
P
-
V
L
-
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
---
S
L
S
G
K
-------
T
-----
I
FSKN
T
N
L
-
P
------------------
V
---------
R
E
R
---
R
------
L
G
----
Y
L
--
V
Q
E
G
V
L
F
----------------
P
H
L
-
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
G
R
-----
T
A
Q
E
R
----------------
Q
R
I
E
A
M
L
E
L
T
G
I
S
E
----
L
-------
A
-
G
R
Y
P
H
E
----
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
------
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
-
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
-
S
P
H
E
L
Y
R
Q
P
A
-----------------------------------------------------------------------------------------------------------------------
67
Fugue
75.54
25%
-92
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
----
I
--
Q
-
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
-------
E
LTTLS
E
--------
S
------------------
E
---------
L
T
K
---
A
------
R
R
----
Q
I
--
G
M
I
F
Q
H
F
-----
N
L
--------
L
S
S
R
-
T
V
F
G
N
V
A
L
P
L
E
L
D
N
T
-----
P
K
D
E
V
K
----------------
R
R
V
T
E
L
L
S
L
V
G
L
G
D
----
K
-------
H
-
D
S
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
-
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
-
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
AQKFIQSTLHLDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------
5
PsiBlast_PDB
75.02
30%
-101
- C1 -
1Z47
1
?
A:
[31-219]
------------------------------
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
---
W
I
--------------------------------------------
G
---------
G
K
R
---
V
------
T
D
----
L
P
--
P
Q
K
---
R
-----
N
V
--------
G
L
V
------------
F
Q
N
Y
A
L
F
Q
-
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
RVP
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
S
----
Y
-------
A
-
N
R
F
P
H
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
-
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
-------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
73.80
24%
-75
- C1 -
1OXS
23
?
C:
[1-352]
-
M
V
R
I
I
V
K
N
V
S
K
V
F
K
KG--
K
----
V
--
V
-
A
L
-
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
---
Y
F
D
D
R
-------
L
-----
V
--------
A
S-----------------
N
---------
G
K
L
---
I
------
V
P
----
P
E
--
D
R
K
I
G
M
V
-----
F
Q
--------
T
W
A
L
-
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
-
M
S
K
E
E
I
R
----------------
K
R
V
E
E
V
A
K
I
L
D
I
H
H
----
V
-------
L
-
N
H
F
P
R
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
------
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
-
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
-
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
VASLIGEINELEGKVTNEGVVIGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
9
PsiBlast_PDB
73.72
29%
-85
- C1 -
2IT1
-
?
A:
[1-212]
-
M
V
E
I
K
L
E
N
I
V
K
K
F
G
----
N
----
F
--
T
-
A
L
-
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
---
Y
F
D
E
K
-------
D
-----
V
TELPPKDR
N
------------------
V
---------
G
L
V
---
F
------
Q
N
----
W
A
LY
P
H
M
T
V
Y
K
-----
N
I
--------
A
F
P
----
L
E
L
R
K
A
P
R
E
E
I
D
K
K
V
R
-
E
V
A
--
K
M
----------------
L
H
I
D
K
L
L
N
R
Y
P
-
W
--------------------
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
------
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
E
-
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
-
I
A
V
I
R
E
G
E
I
-------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.24
25%
-108
- C1 -
4G1U
1
HMUV_YERPE
C:
[12-228]
----
L
E
A
S
H
L
H
Y
H
V
Q
----
Q
----
Q
--
A
-
L
I
-
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
---
H
L
L
G
Q
-------
N
-------------------------------------------------
L
------
N
S
----
W
Q
--
P
K
A
L
A
R
T
-----
R
A
V
M
R
QYSEL
A
F
P
F
-
S
V
S
E
V
I
Q
M
G
R
A
P
Y
G
G
-------
S
Q
D
R
----------------
Q
A
L
Q
Q
V
M
A
Q
T
D
C
L
A
----
L
-------
A
-
Q
R
D
Y
R
V
----
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
Q
-
E
P
L
A
V
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
M
L
L
A
Q
G
K
L
V
A
------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
68.05
31%
-91
- C1 -
1L2T
4
Y796_METJA
B:
[21-205]
------------------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
-------
D
-----
L
--------
D
------------------
D
---------
D
E
L
---
T
KIRRDK
I
G
----
F
V
--
F
Q
Q
---
F
-----
N
L
--------
I
P
L
L
-
T
A
L
E
N
V
E
---
L
P
--
L
I
F
K
Y
R
G
A
M
S
G
E
----------------
E
R
R
K
R
A
L
E
C
L
K
M
A
E
LEER
F
-------
A
-
N
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.54
31%
-91
- C1 -
1L2T
4
Y796_METJA
A:
[21-205]
------------------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
-----
L
--------
D
------------------
D
---------
D
E
L
---
T
K
I
R
R
D
K
I
G
----
F
V
--
F
Q
Q
---
F
-----
N
L
--------
I
P
L
L
-
T
A
L
E
N
V
E
---
L
P
--
L
I
F
K
Y
R
G
A
M
S
G
E
----------------
E
R
R
K
R
A
L
E
C
L
K
M
A
E
LEER
F
-------
A
-
N
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
66.72
31%
-96
- C1 -
3TIF
6
Y796_METJA
B:
[21-205]
------------------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
-------
D
-----
L
--------
D
------------------
D
---------
D
E
L
---
T
KIRRDK
I
G
----
F
V
--
F
Q
Q
---
F
-----
N
L
--------
I
P
L
L
-
T
A
L
E
N
V
E
---
L
P
--
L
I
F
K
Y
R
G
A
M
S
G
E
----------------
E
R
R
K
R
A
L
E
C
L
K
M
A
E
LEER
F
-------
A
-
N
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
65.94
31%
-93
- C1 -
3TIF
7
Y796_METJA
A:
[21-205]
------------------------------
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
-------
D
-----
L
--------
D
------------------
D
---------
D
E
L
---
T
K
I
R
R
D
K
I
G
----
F
V
--
F
Q
Q
---
F
-----
N
L
--------
I
P
L
L
-
T
A
L
E
N
V
E
---
L
P
--
L
I
F
K
Y
R
G
A
M
S
G
E
----------------
E
R
R
K
R
A
L
E
C
L
K
M
A
E
LEER
F
-------
A
-
N
H
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
K
T
V
V
V
V
T
H
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
65.72
32%
-111
- C1 -
4U00
3
?
A:
[19-197]
-----------------------------
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
---
V
V
D
G
L
-------
S
-----
V
--------
K
------------------
D
---------
D
R
A
---
L
R
E
I
R
R
E
V
G
----
M
V
--
F
Q
Q
---
F
-----
N
L
---------
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
R
R
W
P
R
-
E
K
A
E
K
K
A
----------------
L
E
L
---
L
E
R
V
G
I
L
D
----
Q
-------
A
-
R
K
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
--
G
G
M
T
M
V
V
V
T
H
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
50.21
34%
-71
- C1 -
2HYD
3
Y1866_STAAM
A:
[340-513]
----
I
D
I
D
H
V
S
F
Q
Y
N
----
D
----
N
EA
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-----
P
R
F
Y
D
V
---
T
S
G
Q
I
-------
L
-----
I
--------
D
------------------
G
---------
H
N
I
KDF
L
------
T
G
----
S
L
--
R
N
Q
I
G
L
V
QQD--
N
I
--------
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-
P
---------
T
A
T
D
E
----------------
E
V
V
E
A
A
-
K
M
A
N
A
H
D
----
F
I
M
N
LPQG
Y
-
D
T
E
V
G
E
RGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
------
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
49.71
34%
-72
- C1 -
2HYD
3
Y1866_STAAM
B:
[340-513]
----
I
D
I
D
H
V
S
F
Q
Y
N
----
D
----
N
EA
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-----
P
R
F
Y
D
V
---
T
S
G
Q
I
-------
L
-----
I
--------
D
------------------
G
---------
H
N
I
KDF
L
------
T
G
----
S
L
--
R
N
Q
I
G
L
V
QQD--
N
I
--------
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-
P
---------
T
A
T
D
E
----------------
E
V
V
E
A
A
-
K
M
A
N
A
H
D
----
F
IMNLPQG
Y
-
D
T
E
V
G
E
RGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
------
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
47.44
34%
-69
- C1 -
2ONJ
4
Y1866_STAAM
A:
[340-513]
----
I
D
I
D
H
V
S
F
Q
Y
N
----
D
----
N
EA
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-----
P
R
F
Y
D
V
---
T
S
G
Q
I
-------
L
-----
I
--------
D
------------------
G
---------
H
N
I
KDF
L
------
T
G
----
S
L
--
R
N
Q
I
G
L
V
QQD--
N
I
--------
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-
P
---------
T
A
T
D
E
----------------
E
V
V
E
A
A
-
K
M
A
N
A
H
D
----
F
IMNLPQG
Y
-
D
T
E
V
G
E
RGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
------
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
46.92
34%
-69
- C1 -
2ONJ
4
Y1866_STAAM
B:
[340-513]
----
I
D
I
D
H
V
S
F
Q
Y
N
----
D
----
N
EA
P
-
I
L
-
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
-----
P
R
F
Y
D
V
---
T
S
G
Q
I
-------
L
-----
I
--------
D
------------------
G
---------
H
N
I
KDF
L
------
T
G
----
S
L
--
R
N
Q
I
G
L
V
QQD--
N
I
--------
L
F
S
D
-
T
V
K
E
N
I
L
L
G
R
-
P
---------
T
A
T
D
E
----------------
E
V
V
E
A
A
-
K
M
A
N
A
H
D
----
F
IMNLPQG
Y
-
D
T
E
V
G
E
RGVK
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
------
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------