@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0837: (2016-03-19 )
GGIVILKRFFSYYKPYRTLFIIDFGCAVLAAILELAFPVAVNHVIDTLLPGKDFGLIITAALALLFFYILNTFMQYIVTYFGHMLGLNIETDMRRDLFSHLQKQPFGFYDNQKTGKLMSRMTTDLFEIGEVAHHGPEDIFISIMSLFGAFFLMLNINVKLAISTFILVPILTVLIVYFNKRMTKVTTGIFKDLGNFNAGVENAISGVRVVQAFANEPHEKGRFKVLNQAYRKSKLMFYKVMGLSFSFNYFLMRLISLFALLFGAYFTINGEISYGEFVGFILLTNVFIRPIEKINNVIESYPKGFAGFKRFLEVMDTEPAIQDEKDAKPAEAFRGDIAYNQVSFEYSDGKNVLNHINLSIKAGETVAFVGPSGAGKTTICNLLPRFYDVSAGEITIDGENIKRFTLPSLRAQIGVVQQDVFLFSGTVRENIAYGKLDASDEEIEHVVKLAHLSKVVEEMPDGLDTIIGERGVKLSGGQKQRLAIARMFLKNPPILILDEATSALDTETEQVIQASLEELAEGRTTLIIAHRLATIKHADRIIVVNETGIAETGTHDELLAQDNGAYKRLYDAQFNTI
Atome Classification :
(33 SA)
.........10........20-.........30........40........--50------.-------.-..---.--....60.........70........80........90........100.......110.......120.......130.......140........150.......160.......170....-----------...180.......190.......200.......210.-......220.--..--....230---.--......240.......250.....-----..-260-.--.....------...270......---.280.......290.......300..---....-.310....--...320-....--...330.......340....-...--350.--.......360.......370.......380.......390.......400.......410.......420.......430..-..-.---.-.440-.........450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
G
G
I
V
I
L
K
R
F
F
S
Y
YKP
Y
R
T
L
F
--
I
I
DF
G
C
A
V
L
A
A
I
L
E
L
A
F
P
V
A
V
N
H
V
I
D
T
LL--P-------G-------K-
D
F
---
G
--
L
I
I
T
A
-
A
L
A
L
L
F
F
Y
I
L
N
T
F
M
Q
Y
I
V
T
Y
F
G
H
M
LGLNI
E
T
D
M
R
R
D
L
F
S
H
L
Q
KQPFGFYDNQ
K
T
G
K
L
M
S
R
M
T
T
D
L
F
E
I
G
E
V
AHHG
P
E
D
I
F
I
-
S
I
M
S
L
F
G
A
F
F
L
M
L
N
I
N
V
K
L
A
I
S
T
F
I
L
V
P
I
L
T
V
L
I
V
-----------
Y
F
NK
R
M
T
K
V
T
T
G
I
F
K
D
LGNF
N
A
G
V
E
N
A
I
S
G
V
R
V
V
Q
A
F
-ANEPHEK
G
R
F
--
K
V
--
L
N
Q
A
Y
R
K---S--
K
L
M
F
Y
K
V
MGLSF
S
F
N
Y
F
L
M
R
L
I
S
L
-----
F
A
-
L
---
L
--
F
G
A
Y
F
------
T
INGEI
S
Y
G
E
F
V
---
G
F
I
L
L
T
N
V
F
I
R
P
I
E
K
I
N
N
V
I
E
SYP
K
G
---
F
A
G
F
-
K
R
F
L
E
V
MD--TEPAIQ-DEKD--AK
P
A
E
A
FRGDIA
Y
N
Q
V
S
F
E
Y-SDG--
K
N
-
V
--
L
N
HI
N
L
S
I
KAG
E
T
V
A
F
VGPSGAG
K
T
T
I
C
N
L
L
P
R
F
YDVSA
G
E
I
T
IDGEN
I
K
R
FT
L
P
S
L
R
A
Q
IG
V
V
Q
Q
D
V
F
L
FSGTVRENIAYG-KL-D---A-
S
D
---
E
E
I
E
H
V
V
K
L
A
H
L
S
K
V
V
E
EMPD
G
L
D
T
I
I
GERGVKLSGG
Q
K
Q
R
L
A
I
A
R
M
F
LKNP
P
I
L
I
LDEATSALD
T
E
T
E
Q
V
I
Q
A
S
L
E
E
L
AEG
R
T
T
L
I
I
A
H
R
L
A
T
IKHA
D
R
I
I
V
V
NETGIAETGTH
D
E
L
LAQDNG
A
Y
K
R
L
YDAQFNTI
21
PsiBlast_CBE
87.98
37%
-120
- C1 -
2ONJ
4
Y1866_STAAM
B:
[1-576]
----
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
--
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
--
N
-------
N
HALTTDE
K
-
V
H
---
H
--
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
-
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
-----------
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
-
A
I
E
D
N
E
A
K
N
F
--
D
K
--
K
N
T
N
F
L
T
---
R
--
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
-----
I
V
-
I
---
G
--
V
G
A
Y
L
------
A
I
S
G
S
I
T
V
G
T
L
A
---
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
---
F
A
S
M
-
D
R
V
F
Q
L
I
D
--
E
D
Y
D
I
K
-
N
G
V
G
--
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
--
E
A
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
2
PsiBlast_PDB
87.36
37%
-120
- C1 -
2ONJ
4
Y1866_STAAM
A:
[1-576]
----
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
--
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
--
N
-------
N
HALT
T
D
E
K
-
V
H
---
H
--
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
-
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
-----------
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
-
A
I
E
D
N
E
A
K
N
F
--
D
K
--
K
N
T
N
F
L
T
---
R
--
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
-----
I
V
-
I
---
G
--
V
G
A
Y
L
------
A
I
S
G
S
I
T
V
G
T
L
A
---
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
---
F
A
S
M
-
D
R
V
F
Q
L
I
D
--
E
D
Y
D
I
K
-
N
G
V
G
--
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
--
E
A
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
22
PsiBlast_CBE
86.97
37%
-119
- C1 -
2HYD
3
Y1866_STAAM
B:
[1-576]
----
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
--
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
--
N
-------
N
HALTTDE
K
-
V
H
---
H
--
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
-
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
-----------
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
-
A
I
E
D
N
E
A
K
N
F
--
D
K
--
K
N
T
N
F
L
T
---
R
--
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
-----
I
V
-
I
---
G
--
V
G
A
Y
L
------
A
I
S
G
S
I
T
V
G
T
L
A
---
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
---
F
A
S
M
-
D
R
V
F
Q
L
I
D
--
E
D
Y
D
I
K
-
N
G
V
G
--
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
--
E
A
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
1
PsiBlast_PDB
86.93
37%
-119
- C1 -
2HYD
3
Y1866_STAAM
A:
[1-576]
----
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
I
--
F
A
T
I
I
V
G
I
I
K
F
G
I
P
M
L
I
P
L
L
I
K
Y
A
I
D
G
V
I
--
N
-------
N
HALT
T
D
E
K
-
V
H
---
H
--
L
T
I
A
I
-
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
-
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
I
F
P
F
Y
I
L
T
V
Y
-----------
V
F
F
G
R
L
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
-
A
I
E
D
N
E
A
K
N
F
--
D
K
--
K
N
T
N
F
L
T
---
R
--
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
-----
I
V
-
I
---
G
--
V
G
A
Y
L
------
A
I
S
G
S
I
T
V
G
T
L
A
---
A
F
V
G
Y
L
E
L
L
F
G
P
L
R
R
L
V
A
S
F
T
T
L
T
Q
S
---
F
A
S
M
-
D
R
V
F
Q
L
I
D
--
E
D
Y
D
I
K
-
N
G
V
G
--
A
Q
P
I
E
I
K
Q
G
R
I
D
I
D
H
V
S
F
Q
Y
-
N
D
N
--
E
A
P
I
--
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
-
R
P
-
T
---
A
-
T
D
---
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
K
D
R
T
T
L
I
V
A
H
R
L
S
T
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
V
E
T
G
T
H
R
E
L
I
A
K
-
Q
G
A
Y
E
H
L
Y
S
I
Q
----
5
PsiBlast_PDB
85.87
36%
-122
- C1 -
4Q4A
1
Y288_THEMA
B:
[25-593]
-----
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
--
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
--
V
-------
P
-------
R
-
R
F
---
D
--
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
-
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
----------
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
-
T
R
E
E
K
E
M
E
K
F
--
D
R
--
V
N
E
S
L
R
K
------------
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
-
L
---
I
S
G
F
G
G
W
L
------
A
L
K
D
I
I
T
V
G
T
I
A
---
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
---
L
A
S
A
-
E
R
I
F
E
I
L
D
--
L
E
E
E
-
K
-
D
D
P
D
--
A
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
-
6
PsiBlast_PDB
85.35
36%
-118
- C1 -
4Q4H
-
Y288_THEMA
B:
[25-592]
-----
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
--
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
--
V
-------
P
-------
R
-
R
F
---
D
--
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
-
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
----------
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
-
T
R
E
E
K
E
M
E
K
F
--
D
R
--
V
N
E
S
L
R
K
------------
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
-
L
---
I
S
G
F
G
G
W
L
------
A
L
K
D
I
I
T
V
G
T
I
A
---
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
---
L
A
S
A
-
E
R
I
F
E
I
L
D
--
L
E
E
E
-
K
-
D
D
P
D
--
A
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
--
4
PsiBlast_PDB
85.01
36%
-121
- C1 -
3QF4
1
Y288_THEMA
B:
[25-594]
-----
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
--
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
--
V
-------
P
-------
R
-
R
F
---
D
--
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
-
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
----------
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
-
T
R
E
E
K
E
M
E
K
F
--
D
R
--
V
N
E
S
L
R
K
------------
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
-
L
---
I
S
G
F
G
G
W
L
------
A
L
K
D
I
I
T
V
G
T
I
A
---
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
---
L
A
S
A
-
E
R
I
F
E
I
L
D
--
L
E
E
E
-
K
-
D
D
P
D
--
A
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
L
V
7
PsiBlast_PDB
83.92
36%
-119
- C1 -
4Q4J
-
Y288_THEMA
B:
[25-592]
-----
L
R
R
L
L
G
Y
L
R
P
H
T
F
T
L
--
I
M
V
F
V
F
V
T
V
S
S
I
L
G
V
L
S
P
Y
L
I
G
K
T
I
D
V
V
F
--
V
-------
P
-------
R
-
R
F
---
D
--
L
L
P
R
Y
-
M
L
I
L
G
T
I
Y
A
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
-
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
S
I
V
P
-
L
T
V
L
I
T
Q
I
V
S
S
Q
T
R
K
Y
F
Y
E
N
Q
R
V
----------
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
-
T
R
E
E
K
E
M
E
K
F
--
D
R
--
V
N
E
S
L
R
K
------------
V
G
T
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
-
L
---
I
S
G
F
G
G
W
L
------
A
L
K
D
I
I
T
V
G
T
I
A
---
T
F
I
G
Y
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
---
L
A
S
A
-
E
R
I
F
E
I
L
D
--
L
E
E
E
-
K
-
D
D
P
D
--
A
V
E
L
R
E
V
R
G
E
I
E
F
K
N
V
W
F
S
Y
-
D
K
K
--
K
P
-
V
--
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
D
V
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
-
N
P
-
G
---
A
-
T
D
---
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
E
G
K
T
S
I
I
I
A
H
R
L
N
T
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
H
D
E
L
I
-
Q
K
R
G
F
Y
Y
E
L
F
T
S
Q
Y
G
--
15
PsiBlast_PDB
81.18
32%
-112
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[3-572]
-
G
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
--
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-------
T
-------
V
-
D
Y
---
S
--
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
-
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
-----------
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
-
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
-------
L
I
V
L
-----
S
V
-
L
---
Y
--
K
G
G
L
L
------
M
G
S
A
H
M
T
V
G
E
L
S
---
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
---
L
G
A
G
-
G
R
L
W
E
L
L
E
--
R
E
P
K
L
P
F
N
E
G
V
--
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
E
-
V
PI
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
---------------
14
PsiBlast_PDB
81.05
32%
-113
- C1 -
4AYX
7
ABCBA_HUMAN
A:
[4-574]
--
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
--
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-------
T
-------
V
-
D
Y
---
S
--
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
-
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
-----------
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
-
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
-------
L
I
V
L
-----
S
V
-
L
---
Y
--
K
G
G
L
L
------
M
G
S
A
H
M
T
V
G
E
L
S
---
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
---
L
G
A
G
-
G
R
L
W
E
L
L
E
--
R
E
P
K
L
P
F
N
E
G
V
--
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
E
-
V
PI
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
-------------
17
PsiBlast_PDB
80.57
32%
-120
- C1 -
4RY2
-
?
A:
[160-727]
-------
K
F
A
G
F
L
K
P
L
K
K
T
V
--
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
--
K
-------
F
-------
E
-
K
L
---
N
D
L
H
I
I
S
A
-
G
F
A
V
I
F
--
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
-
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
-----------
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
--
D
K
--
I
E
T
V
M
K
S
---
S
F
K
E
G
M
L
Y
--
I
N
L
S
-
S
L
T
G
I
V
A
G
L
G
G
I
-----
V
I
-
L
---
W
--
A
G
A
Y
N
------
V
I
K
G
N
M
S
G
G
Q
L
L
---
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
---
V
V
A
S
-
N
R
L
G
E
I
L
E
LA
T
E
K
E
L
----------------
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
--
K
P
-
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
-
D
M
---
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
E
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
E
N
T
-
104
HHSearch
80.23
34%
-105
- C1 -
3B60
2
MSBA_SALTY
A:
[12-581]
----
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
--
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
--
G
-------
K
-------
T
-
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
--
D
K
--
V
S
N
K
M
R
L
---
Q
--
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
-----
F
V
-
L
---
Y
--
A
A
S
F
P
------
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
Q
E
K
D
-
E
G
K
----
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
R
E-
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
E
E
---
Y
-
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
125
Fugue
79.88
34%
-105
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
--
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
--
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
K
P
L
L
D
D
G
F
--
G
-------
K
-------
T
-
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
--
D
K
--
V
S
N
K
M
R
L
---
Q
--
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
-----
F
V
-
L
---
Y
--
A
A
S
F
P
------
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
Q
E
K
D
-
E
G
K
----
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
E
--
V
P
-
A
--
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
--
13
PsiBlast_PDB
79.38
32%
-111
- C1 -
4AYT
8
ABCBA_HUMAN
A:
[4-567]
--
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
--
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
T
N
P
-------
T
-------
V
-
D
Y
---
S
--
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
-
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
-----------
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
-
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
-------
L
I
V
L
-----
S
V
-
L
---
Y
--
K
G
G
L
L
------
M
G
S
A
H
M
T
V
G
E
L
S
---
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
---
L
G
A
G
-
G
R
L
W
E
L
L
E
--
R
E
P
K
L
P
F
N
E
G
V
--
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
E
-
V
PI
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
--------------------
24
PsiBlast_CBE
79.15
36%
-104
- C1 -
3B60
2
MSBA_SALTY
C:
[10-580]
------------
W
Q
T
F
R
R
L
W
PT
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
--
K
PLLDDGF
G
-------
K
T
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
-------
D
K
V
S
N
K
---
M
--
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
-----
L
A
-
L
AFV
L
--
Y
A
A
S
F
P-----
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
-----
Q
E
K
D
EG
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
--
R
E
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
23
PsiBlast_CBE
79.02
36%
-104
- C1 -
3B60
2
MSBA_SALTY
D:
[10-580]
------------
W
Q
T
F
R
R
L
W
PT
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
--
K
PLLDDGF
G
-------
K
T
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
-------
D
K
V
S
N
K
---
M
--
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
-----
L
A
-
L
AFV
L
--
Y
A
A
S
F
P-----
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
-----
Q
E
K
D
EG
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
--
R
E
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
25
PsiBlast_CBE
78.98
36%
-104
- C1 -
3B60
2
MSBA_SALTY
B:
[10-580]
------------
W
Q
T
F
R
R
L
W
PT
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
--
K
PLLDDGF
G
-------
K
T
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
-------
D
K
V
S
N
K
---
M
--
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
-----
L
A
-
L
AFV
L
--
Y
A
A
S
F
P-----
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
-----
Q
E
K
D
EG
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
--
R
E
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
106
HHSearch
78.96
30%
-111
- C1 -
3ZDQ
6
ABCBA_HUMAN
A:
[4-572]
--
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
--
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
--
T
-------
N
-------
P
-
T
V
DY
S
D
--
N
L
T
R
L
-
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
-
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
-----------
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
-
G
K
E
M
T
E
I
E
K
Y
--
A
S
--
K
V
D
H
V
M
Q
---
L
--
A
R
K
E
A
F
A
R
A
G
F
F
G
A
T
G
L
S
G
N
L
I
V
L
-----
S
V
-
L
---
Y
--
K
G
G
L
L
------
M
G
S
A
H
M
T
V
G
E
L
S
---
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
---
L
G
A
G
-
G
R
L
W
E
L
L
E
--
R
E
P
K
L
P
-
F
N
E
G
V
-
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
PE
V
P
-
I
--
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
PSS
V
-
T
A
---
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
---------------
32
PsiBlast_CBE
78.68
32%
-110
- C1 -
4S0F
2
?
B:
[161-725]
--------
F
A
G
F
L
K
P
L
K
K
T
V
--
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
--
K
-------
F
-------
E
-
K
L
---
N
DL
H
I
I
S
A
-
G
F
A
V
I
F
--
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
-
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
-----------
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
--
D
K
--
I
E
T
V
M
K
S
---
S
FK
E
G
M
L
Y
--
I
N
L
S
-
S
L
T
G
I
V
A
G
L
G
G
I
-----
V
I
-
L
---
W
--
A
G
A
Y
N
------
V
I
K
G
N
M
S
G
G
Q
L
L
---
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
---
V
V
A
S
-
N
R
L
G
E
I
L
E
LA
T
E
K
E
L
R
-
E
D
S
D
---
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
--
K
P
-
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
-
D
M
---
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
E
---
10
PsiBlast_PDB
78.31
36%
-104
- C1 -
3B60
2
MSBA_SALTY
A:
[10-580]
------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
L
--
K
PLLDDGF
G
-------
K
T
D
R
---
S
--
V
L
L
W
M
-
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
-
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
-----------
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
-
G
G
Q
E
V
E
T
K
R
F
-------
D
K
V
S
N
K
---
M
--
R
L
Q
G
M
K
M
V
S
A
S
-
S
I
S
D
P
I
I
Q
L
I
A
S
-----
L
A
-
L
A
F
V
L
--
Y
A
A
S
F
P-----
S
V
M
D
S
L
T
A
G
T
I
T
---
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
---
M
A
A
C
-
Q
T
L
F
A
I
L
D
--
S
E
-----
Q
E
K
D
E
G
K
R
V
I
D
R
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
-
P
-
G
--
R
E
-
V
PA
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
-
R
T
-
E
---
E
Y
S
R
---
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
T
S
L
V
I
A
H
R
L
S
T
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
-
H
G
V
Y
A
Q
L
H
K
M
Q
F
---
18
PsiBlast_PDB
77.93
32%
-107
- C1 -
4S0F
2
?
A:
[161-725]
--------
F
A
G
F
L
K
P
L
K
K
T
V
--
L
C
I
F
L
A
S
L
L
Y
T
A
L
G
I
A
G
S
F
Y
I
K
F
L
F
D
D
L
I
--
K
-------
F
-------
E
-
K
L
---
N
D
L
H
I
I
S
A
-
G
F
A
V
I
F
--
L
L
Q
I
F
L
N
Y
Y
R
S
I
L
V
T
K
L
G
M
S
I
D
K
S
I
M
M
E
Y
Y
S
H
V
L
K
L
P
M
N
F
F
N
S
R
K
V
G
E
I
I
S
R
F
M
-
D
A
S
K
I
R
Q
A
I
S
G
A
T
L
T
I
M
I
D
T
I
M
A
V
I
G
G
I
L
L
Y
I
Q
-
N
S
S
L
F
F
I
S
F
I
I
I
L
L
Y
G
I
I
V
T
-----------
V
F
N
K
P
I
Q
N
A
N
R
Q
I
M
E
D
N
A
K
L
T
S
A
L
V
E
S
V
K
G
I
E
T
I
K
S
F
G
A
E
E
Q
T
E
K
S
T
R
--
D
K
--
I
E
T
V
M
K
S
---
S
F
K
E
G
M
L
Y
--
I
N
L
S
-
S
L
T
G
I
V
A
G
L
G
G
I
-----
V
I
-
L
---
W
--
A
G
A
Y
N
------
V
I
K
G
N
M
S
G
G
Q
L
L
---
A
F
N
A
L
L
A
Y
F
L
T
P
V
K
N
L
I
D
L
Q
P
L
I
Q
T
A
---
V
V
A
S
-
N
R
L
G
E
I
L
E
L
A
T
E
K
E
L
R
-
E
D
S
D
---
D
F
V
I
S
L
K
G
D
I
E
F
R
N
V
D
F
R
Y
-
G
L
R
--
K
P
-
V
--
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
S
P
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
-
N
E
-
N
---
V
-
D
M
---
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
D
D
V
T
V
I
I
I
A
H
R
L
S
T
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
V
E
S
G
S
H
T
E
L
I
A
L
-
K
G
C
Y
F
K
M
W
K
Q
T
E
---
16
PsiBlast_PDB
77.67
31%
-116
- C1 -
4AYW
3
ABCBA_HUMAN
A:
[35-598]
--
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
L
--
A
A
A
V
G
F
L
T
M
S
S
V
I
S
M
S
A
P
F
F
L
G
K
I
I
D
V
I
Y
TN
P
-------
T
-------
V
-
D
Y
---
S
--
D
N
L
T
R
L
C
L
G
L
S
A
V
F
L
C
G
A
A
A
N
A
I
R
V
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
-
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
V
-----------
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
-
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
L
A
R
K
E
A
F
A
--
R
A
G
F
F
G
A
T
G
L
S
G
N
-------
L
I
V
L
-----
S
V
-
L
---
Y
--
K
G
G
L
L
------
M
G
S
A
H
M
T
V
G
E
L
S
---
S
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
L
S
S
F
Y
S
E
L
M
K
G
---
L
G
A
G
-
G
R
L
W
E
L
L
E
--
R
E
P
K
L
P
F
N
E
G
V
--
I
L
N
E
K
S
F
Q
G
A
L
E
F
K
N
V
H
F
A
Y
-
P
A
R
--
P
E
-
V
PI
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
-
A
D
-
D
---
P
-
S
S
VT
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
--------------------
55
PsiBlast_CBE
61.92
44%
-99
- C1 -
3NH9
3
A:
[20-289]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HM-
F
I
D
M
-
E
N
M
F
D
L
L
K
--
E
E
T
E
V
K
-
D
L
P
G
--
A
G
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
G
--
R
E
-
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
N
---
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
-
G
G
V
Y
A
D
M
W
Q
L
Q
----
53
PsiBlast_CBE
60.87
44%
-105
- C1 -
3NHB
3
A:
[16-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
SHM
F
I
D
M
-
E
N
M
F
D
L
L
K
--
E
E
T
E
V
K
-
D
L
P
G
--
A
G
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
---
R
E
-
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
N
---
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
-
G
G
V
Y
A
D
M
W
Q
L
Q
----
54
PsiBlast_CBE
60.84
44%
-104
- C1 -
3NHA
4
A:
[16-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
SHM
F
I
D
M
-
E
N
M
F
D
L
L
K
--
E
E
T
E
V
K
-
D
L
P
G
--
A
G
P
L
R
F
Q
K
G
R
I
E
F
E
N
V
H
F
S
Y
-
A
D
---
R
E
-
T
--
L
Q
D
V
S
F
T
V
M
P
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
Y
D
I
S
S
G
C
I
R
I
D
G
Q
D
I
S
Q
V
T
Q
A
S
L
R
S
H
I
G
V
V
P
Q
D
T
V
L
F
N
D
T
I
A
D
N
I
R
Y
G
-
R
V
-
T
---
A
-
G
N
---
D
E
V
E
A
A
A
Q
A
A
G
I
H
D
A
I
M
A
F
P
E
G
Y
R
T
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
C
A
N
R
T
T
I
V
V
A
H
R
L
S
T
V
V
N
A
D
Q
I
L
V
I
K
D
G
C
I
V
E
R
G
R
H
E
A
L
L
S
R
-
G
G
V
Y
A
D
M
W
Q
L
Q
----
58
PsiBlast_CBE
59.68
50%
-110
- C1 -
1MV5
3
LMRA_LACLA
C:
[2-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
-
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-----------------
113
HHSearch
59.36
49%
-102
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
-
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
-
L
E
-
G
D--
Y
-
T
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
T
-
H
P
L
Y
A
K
Y
V
S
E
Q
----
59
PsiBlast_CBE
58.49
50%
-105
- C1 -
1MV5
2
LMRA_LACLA
B:
[2-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
-
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-----------------
60
PsiBlast_CBE
57.59
50%
-105
- C1 -
1MV5
3
LMRA_LACLA
A:
[2-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
-
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-----------------
57
PsiBlast_CBE
56.74
50%
-109
- C1 -
1MV5
3
D:
[2-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
R
H
V
D
F
A
Y
-
D
D
S
--
E
Q
-
I
--
L
R
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
Y
Q
P
T
A
G
E
I
T
I
D
G
Q
P
I
D
N
I
S
L
E
N
W
R
S
Q
I
G
F
V
S
Q
D
S
A
I
M
A
G
T
I
R
E
N
L
T
Y
G
L
E
G
-
D
---
Y
-
T
D
---
E
D
L
W
Q
V
L
D
L
A
F
A
R
S
F
V
E
N
M
P
D
Q
L
N
T
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
M
K
G
R
T
T
L
V
I
A
H
R
L
S
T
I
V
D
A
D
K
I
Y
F
I
E
K
G
Q
I
T
G
S
G
K
H
N
E
L
V
A
-----------------
61
PsiBlast_CBE
56.72
46%
-103
- C1 -
5DGX
1
?
A:
[5-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
T
G
--
S
K
E
L
A
K
V
D
G
N
V
T
I
K
D
L
S
F
A
F
-
G
E
H
--
K
--
V
--
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
H
E
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
----
E
---
V
-
S
E
---
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
K
S
C
T
T
I
V
I
A
H
R
L
S
T
V
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
H
Q
E
L
L
E
Q
-
G
G
L
Y
T
R
L
Y
Q
S
-----
90
PsiBlast_CBE
52.39
32%
-88
- C1 -
4PL0
4
MCJD_ECOLX
B:
[240-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
A
Q
K
K
---
Y
--
W
L
L
S
S
K
V
L
L
L
N
-----------
S
L
-----
L
A
V
I
---
L
--
F
G
S
V
F
I
Y
N
I
L
G
V
L
N
G
V
V
S
I
G
H
F
I
M
I
T
S
Y
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
---
L
A
G
F
I
Q
R
H
A
E
N
K
A
--
T
S
P
S
I
P
-
F
L
N
M
--
E
R
-----
K
L
N
L
S
I
R
E
L
S
F
S
Y
-
S
D
D
--
K
K
-
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
F
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
-
N
Y
-
D
---
A
-
S
E
---
N
E
I
F
K
V
L
K
L
A
N
L
S
-
V
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
H
F
P
D
A
L
I
I
N
I
S
H
R
I
N
L
L
E
C
S
D
C
V
Y
V
L
N
E
G
N
I
V
A
S
G
H
F
R
D
L
M
V
S
N
---------------
91
PsiBlast_CBE
50.25
32%
-88
- C1 -
4PL0
4
MCJD_ECOLX
A:
[240-569]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
A
Q
K
K
---
Y
--
W
L
L
S
S
K
V
L
L
L
N
-----------
S
L
-----
L
A
V
I
---
L
--
F
G
S
V
F
I
Y
N
I
L
G
V
L
N
G
V
V
S
I
G
H
F
I
M
I
T
S
Y
I
I
L
L
S
T
P
V
E
N
I
G
A
L
L
S
E
I
R
Q
S
M
S
S
---
L
A
G
F
I
Q
R
H
A
E
N
K
A
--
T
S
P
S
I
P
-
F
L
N
M
--
E
R
-----
K
L
N
L
S
I
R
E
L
S
F
S
Y
-
S
D
D
--
K
K
-
I
--
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
Y
F
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
-
N
Y
-
D
---
A
-
S
E
---
N
E
I
F
K
V
L
K
L
A
N
L
S
-
V
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
H
F
P
D
A
L
I
I
N
I
S
H
R
I
N
L
L
E
C
S
D
C
V
Y
V
L
N
E
G
N
I
V
A
S
G
H
F
R
D
L
M
V
S
N
---------------