@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0906: (2016-03-19 )
MEKHYDYIAIGGGSGGIASINRAAMHGAKCALIEPKFLGGTCVNVGCVPKKVMWYGAQIKEAMDLYADAYGYQVDASFNFQKLVENREAYIERIRGSYKNGLDNNNVDWIKGYAEFVDEKTLRVNGELVTADHILIATGGEPALPSIPGAEFGITSDGFFALKELPKKVAVVGAGYIAVELAGVLQQLGSETHLFVRKHAPLRNFDPLLTDTLTEIIEQSDMTLHKHAIPQKVEKNPDGSLTLSLEDGRTETVDTLIWAIGRKPVIKGLQIEKSGVELLESGHIAVDKFQNTNVAGIYAVGDVTGHYELTPVAIAAGRRLSERLFNNKKDAHLNYENIPTVVFSHPAIGTVGLTEPEAIEKYGKENIKVYTSSFTSMYTAITDHREPCRMKLICEGKTERVIGLHGIGYGVDEMIQGFAVAINMGATKADFDNTVAIHPTGSEEFVTMK
Atome Classification :
(71 SA)
--------------------------------------------------------------------------------------------------.........10......-..20.....-...30.---.---------.-------..---------.------..40........50........60........--70.-----.-.---.-..---.---.80........90........100.-....-...110....-------..--.120...--.-----.---------.---------.-----.-----.130.......140...---.-...150........160.....---------..170.......180...---..-.---.190.......200.......210.......220.......230.--------...--------...240.---.--..----.---.------.--250---..------.......260.......270......-.280.-......290.......300-----.-.-.----..-..310.......320..--.....330.......340.......350.......360...-....370..--.....380-..----.----.-..--..390..-.-..-.-.400.......410.......420.......430.......440.......-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------MEK
H
Y
D
Y
I
A
I
GGGSG
G
I
-
A
S
I
N
R
A
A
MH-G
A
K
C
A
L---I---------E-------PK---------F------LG
G
T
C
V
NVGCV
P
K
K
V
M
W
Y
G
A
Q
I
K
E
A
M
D
L
Y
ADA--Y
G
Y
-----
Q
-V---D-AS---F---
N
F
Q
K
L
V
E
N
R
E
A
Y
I
E
R
I
R
G
S
YKNG-L-DNN
N
-
V
D
W
I
K
G
Y
A
E
F
-------VD--EK--
T
L
R
--V-----N---------
G
---------
E
-----
L
-----
V
T
A
D
H
I
L
I
ATGGEPALP---S-IPGA-EFGITS
D
G
F
F
A
L
K
EL
P
K
---------
K
V
A
V
VGA
G
Y
I
A
V
E
L
A
G
V
L
---
Q
Q
-L---GSET
H
L
F
V
R
KHAPLRNF
D
P
L
L
T
D
T
L
T
E
I
I
E
QSDM
T
L
H
K
HAI
P
Q
K
V
--------EKN--------PDG
S
L
T
L
---
S
--LE----D---G------R--T-----
E
T
------
V
D
T
L
I
W
AIGRKPVIKG
L
Q
I
E
K
S
G
V
E
L
-
L
ESG
H
-
I
A
V
D
KFQNTN
V
A
G
I
Y
A
V
GD-----V-T-G----H
Y
-
E
L
T
P
V
A
IAA
G
R
R
L
S
E
R
L
--FNNKKDAHLNYENI
P
T
V
V
FSHPAIGTVGLT
E
P
E
A
I
E
K
YGKE-
N
I
K
V
Y
TSS
F
--
T
S
M
Y
T
A
I
--TD----H----R-EP--
C
R
M
K
L
I
C-E-GK-T-
E
R
V
I
G
LHGIGY
G
V
D
E
M
I
Q
G
F
A
V
A
I
NMGATKADFD
N
T
V
A
I
HPTGSE
E
F
V
TMK-----------
1
PsiBlast_PDB
97.88
69%
-99
- C2 -
1GER
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
2
PsiBlast_PDB
95.32
69%
-97
- C2 -
1GET
3
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
22
PsiBlast_CBE
94.94
69%
-95
- C2 -
1GER
2
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
23
PsiBlast_CBE
94.30
67%
-96
- C2 -
1GEU
3
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
24
PsiBlast_CBE
94.27
67%
-97
- C2 -
1GES
2
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
101
HHSearch
93.76
68%
-98
- C2 -
1GES
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
T--
I
-
N
K
---
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
3
PsiBlast_PDB
93.45
67%
-98
- C2 -
1GES
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
21
PsiBlast_CBE
93.40
69%
-96
- C2 -
1GET
3
GSHR_ECOLI
B:
[2-450]
---------------------------------------------------------------------------------------------------
T
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
4
PsiBlast_PDB
92.73
67%
-97
- C2 -
1GEU
3
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
D
--
Y
G
F
-----
D
-
T
---
T
-
I
N
K--
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
-
V
D
V
I
K
G
F
A
R
F
-------
V
D
--
A
K
--
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
-
I
P
G
V
-
E
Y
G
I
D
S
D
G
F
F
A
L
P
A
L
P
E
---------
R
V
A
V
V
G
A
G
Y
I
G
V
E
L
G
G
V
I
---
N
G
-
L
---
G
A
K
T
H
L
F
E
M
F
D
A
P
L
P
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
---
G
------
R
--
S
-----
E
T
------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
V
-
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
--
F
N
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
M
Y
T
A
V
--
T
T
----
H
----
R
-
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
V
A
I
H
P
T
A
A
E
E
F
V
T
M
R
-----------
10
PsiBlast_PDB
92.06
54%
-102
- C2 -
1BWC
3
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
20
PsiBlast_PDB
91.26
54%
-97
- C2 -
3DK8
8
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
19
PsiBlast_PDB
91.15
54%
-100
- C2 -
3DK4
5
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
26
PsiBlast_CBE
90.59
54%
-95
- C2 -
3SQP
6
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
27
PsiBlast_CBE
90.58
54%
-96
- C2 -
3DK9
4
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
30
PsiBlast_CBE
90.45
54%
-99
- C2 -
1XAN
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
25
PsiBlast_CBE
90.44
54%
-95
- C2 -
3SQP
6
GSHR_HUMAN
B:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
HES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
MTMIPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
14
PsiBlast_PDB
90.06
54%
-98
- C2 -
1GRE
4
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
18
PsiBlast_PDB
89.96
54%
-97
- C2 -
3DJJ
19
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
15
PsiBlast_PDB
89.86
54%
-98
- C2 -
1GRF
3
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
12
PsiBlast_PDB
89.82
54%
-100
- C2 -
1GRA
4
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
28
PsiBlast_CBE
89.75
54%
-97
- C2 -
3DJG
2
GSHR_HUMAN
X:
[20-477]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
HES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
MTMIPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
31
PsiBlast_CBE
89.64
54%
-97
- C2 -
2AAQ
13
GSHR_HUMAN
A:
[22-479]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
11
PsiBlast_PDB
89.49
54%
-98
- C2 -
2GH5
13
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
8
PsiBlast_PDB
89.45
53%
-99
- C2 -
5GRT
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
29
PsiBlast_CBE
89.38
54%
-98
- C2 -
2GH5
14
GSHR_HUMAN
B:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
HES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
MTMIPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
13
PsiBlast_PDB
89.32
54%
-98
- C2 -
1GRB
3
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
16
PsiBlast_PDB
89.29
54%
-98
- C2 -
3GRS
2
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
17
PsiBlast_PDB
89.28
54%
-98
- C2 -
4GR1
3
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
KP
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
5
PsiBlast_PDB
88.83
53%
-98
- C2 -
2GRT
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
V
P
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
6
PsiBlast_PDB
88.63
53%
-98
- C2 -
3GRT
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
M
T
M
IPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
9
PsiBlast_PDB
87.78
53%
-97
- C2 -
1GRT
1
GSHR_HUMAN
A:
[21-478]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
A
VP
G
------
R
--
L
-----
P
V
M
T
M
IPD
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
7
PsiBlast_PDB
87.71
53%
-100
- C2 -
4GRT
2
GSHR_HUMAN
A:
[4-461]
------------------------------------------------------------------------------------------------------
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
E
S
A
W
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
H
A
D
---
Y
G
F
P
----
S
-
C
---
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
--
D
P
K
P
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
---
S
--
M
V
----
T
AVP
G
------
R
--
L
-----
P
V
M
T
M
I
P
D
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
G
I
E
-
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
114
HHSearch
87.15
55%
-91
- C2 -
3DK9
4
GSHR_HUMAN
A:
[18-478]
---------------------------------------------------------------------------------------------------
V
A
S
Y
D
Y
L
V
I
G
G
G
S
G
G
L
-
A
S
A
R
R
A
A
E
L
-
G
A
R
A
A
V
---
V
---------
E
-------
S
H
---------
K
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
N
T
A
V
H
S
E
F
M
H
D
-
H
A
D
--
Y
G
F
-----
P
-
S
C--
E
-
G
K
---
F
---
N
W
R
V
I
K
E
K
R
D
A
Y
V
S
R
L
N
A
I
Y
Q
N
N
-
L
-
T
K
S
H
-
I
E
I
I
R
G
H
A
A
F
-------
T
S
DP
K
P
--
T
I
E
--
V
-----
S
---------
G
---------
K
-----
K
-----
Y
T
A
P
H
I
L
I
A
T
G
G
M
P
S
T
P
H
ES
Q
-
I
P
G
A
-
S
L
G
I
T
S
D
G
F
F
Q
L
E
E
L
P
G
---------
R
S
V
I
V
G
A
G
Y
I
A
V
E
M
A
G
I
L
---
S
A
-
L
---
G
S
K
T
S
L
M
I
R
H
D
K
V
L
R
S
F
D
S
M
I
S
T
N
C
T
E
E
L
E
N
A
G
V
E
V
L
K
F
S
Q
V
K
E
V
--------
K
K
T
--------
L
S
G
-
L
E
V
S
M
V
T
--
A
V
----
P
---
G
R
L
P
V
M
T
M
--
I
-----
P
D
------
V
D
C
L
L
W
A
I
G
R
V
P
N
T
K
D
L
S
L
N
K
L
G
I
Q
T
-
D
D
K
G
H
-
I
I
V
D
E
F
Q
N
T
N
V
K
G
I
Y
A
V
G
D
-----
V
-
C
-
G
----
K
A
-
L
L
T
P
V
A
I
A
A
G
R
K
L
A
H
R
L
--
F
E
Y
K
E
D
S
K
L
D
Y
N
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
D
E
A
I
H
K
Y
-
G
I
E
N
V
K
T
Y
S
T
S
F
--
T
P
M
Y
H
A
V
--
T
K
----
R
----
K
-
T
K
--
C
V
M
K
M
V
C
-
A
-
N
K
-
E
-
E
K
V
V
G
I
H
M
Q
G
L
G
C
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
T
S
S
E
E
L
V
T
L
R
-----------
123
Fugue
87.08
63%
-97
- C2 -
1GER
2
GSHR_ECOLI
A:
[3-450]
----------------------------------------------------------------------------------------------------
K
H
Y
D
Y
I
A
I
G
G
G
S
G
G
I
-
A
S
I
N
R
A
A
M
Y
-
G
Q
K
C
A
L
---
I
---------
E
-------
A
K
---------
E
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
H
A
A
Q
I
R
E
A
I
H
M
Y
G
P
----
D
Y
GFDTT
I
-------
N
K
---
F
---
N
W
E
T
L
I
A
S
R
T
A
Y
I
D
R
I
H
T
S
Y
E
N
V
-
L
-
G
K
N
N
V
D
V
I
K
-
G
F
A
R
F
-------
V
---
D
A
K-
T
L
E
--
V
-----
N
---------
G
---------
E
-----
T
-----
I
T
A
D
H
I
L
I
A
T
G
G
R
P
S
H
P
---
D
----
I
-
P
-
G
V
--
E
Y
G
I
D
---
S
D
G
F
F
A
LPALPE
R
V
A
V
V
G
A
G
Y
I
A
V
E
L
A
G
V
I
---
N
G
L
----
G
A
K
T
H
L
F
V
R
K
H
A
P
L
R
S
F
D
P
M
I
S
E
T
L
V
E
V
M
N
A
E
G
P
Q
L
H
T
N
A
I
P
K
A
V
--------
V
K
N
--------
T
D
G
S
L
T
L
---
E
--
L
E
----
D
----G
R
----
S
--
E
-----
T
-------
V
D
C
L
I
W
A
I
G
R
E
P
A
N
D
N
I
N
L
E
A
A
G
V
K
T
-
N
E
K
G
Y
-
I
V
V
D
K
Y
Q
N
T
N
I
E
G
I
Y
A
V
G
D
-----
N
-
T
-
G
----
A
-V
E
L
T
P
V
A
V
A
A
G
R
R
L
S
E
R
L
FN--
N
K
P
D
E
H
L
D
Y
S
N
I
P
T
V
V
F
S
H
P
P
I
G
T
V
G
L
T
E
P
Q
A
R
E
Q
Y
G
D
D
-
Q
V
K
V
Y
K
S
S
F
--
T
A
---
M
Y
--
T
A
----
V
TTH
R
--
Q
P
--
C
R
M
K
L
V
C
-
V
-
G
S
-
E
-
E
K
I
V
G
I
H
G
I
G
F
G
M
D
E
M
L
Q
G
F
A
V
A
L
K
M
G
A
T
K
K
D
F
D
N
T
--
V
A
I
H
P
T
--
A
A
E
E
F
VTMR-------
120
HHSearch
82.63
51%
-89
- C2 -
2R9Z
8
GASHR_MARGR
A:
[2-447]
---------------------------------------------------------------------------------------------------
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
-
G
K
R
V
A
L
---
I
---------
E
-------
S
K
---------
A
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
D
-
A
P
G
--
F
G
V
-----
Q
-
A
S---------
L
---
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
-------
V
D
--
A
H
--
T
I
E
--
V
-----
E
---------
G
---------
Q
-----
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
---
R
-
L
P
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
---
R
S
-
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
--------
E
R
D
--------
A
Q
G
-
T
T
L
---
V
--
A
Q
----
D
---
G
------
T
--
R
L
----
E
G
------
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
-
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
D
--
V
L
T
V
Y
E
T
S
F
--
T
P
M
R
Y
A
L
--
N
E
----
H
----
G
-
P
K
--
T
A
M
K
L
V
C
-
A
-
G
P
-
E
-
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
------------
32
PsiBlast_CBE
82.38
51%
-87
- C2 -
2R9Z
8
GASHR_MARGR
B:
[2-448]
---------------------------------------------------------------------------------------------------
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
-
G
K
R
V
A
L
---
I
---------
E
-------
S
K
---------
A
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
---
D
A
--
P
G
F
-----
G
-
V
---
Q
-
A
S
GT-
L
---
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
-------
V
D
--
A
H
--
T
I
E
--
V
-----
E
---------
G
---------
Q
-----
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
---
R
-
L
P
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
---
R
S
-
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
--------
E
R
D
--------
A
Q
G
T
-
T
L
---
V
--
A
Q
----
D
---
G
T-----
R
--
L
-----
E
G
------
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
-
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
-
V
L
T
V
Y
E
T
S
F
--
T
P
M
R
Y
A
L
--
N
E
----
H
----
G
-
P
K
--
T
A
M
K
L
V
C
-
A
-
G
P
-
E
-
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
K
-----------
33
PsiBlast_CBE
80.80
51%
-86
- C2 -
2R9Z
8
GASHR_MARGR
A:
[2-448]
---------------------------------------------------------------------------------------------------
T
Q
H
F
D
L
I
A
I
G
G
G
S
G
G
L
-
A
V
A
E
K
A
A
A
F
-
G
K
R
V
A
L
---
I
---------
E
-------
S
K
---------
A
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
V
M
W
Y
A
S
H
L
A
E
A
V
R
---
D
A
--
P
G
F
-----
G
-
V
---
Q
-
A
S
---
L
---
D
W
P
R
L
V
A
G
R
D
R
Y
I
G
A
I
N
S
F
W
D
G
Y
-
V
-
E
R
L
G
-
I
T
R
V
D
G
H
A
R
F
-------
V
D
--
A
H
--
T
I
E
--
V
-----
E
---------
G
---------
Q
-----
R
-----
L
S
A
D
H
I
V
I
A
T
G
G
R
P
I
V
P
---
R
-
L
P
G
A
-
E
L
G
I
T
S
D
G
F
F
A
L
Q
Q
Q
P
K
---------
R
V
A
I
I
G
A
G
Y
I
G
I
E
L
A
G
L
L
---
R
S
-
F
---
G
S
E
V
T
V
V
A
L
E
D
R
L
L
F
Q
F
D
P
L
L
S
A
T
L
A
E
N
M
H
A
Q
G
I
E
T
H
L
E
F
A
V
A
A
L
--------
E
R
D
--------
A
Q
G
T
-
T
L
---
V
--
A
Q
----
D
---
G
T
-----
R
--
L
-----
E
G
------
F
D
S
V
I
W
A
V
G
R
A
P
N
T
R
D
L
G
L
E
A
A
G
I
E
V
-
Q
S
N
G
M
-
V
P
T
D
A
Y
Q
N
T
N
V
P
G
V
Y
A
L
G
D
-----
I
-
T
-
G
----
R
D
-
Q
L
T
P
V
A
I
A
A
G
R
R
L
A
E
R
L
--
F
D
G
Q
S
E
R
K
L
D
Y
D
N
I
P
T
V
V
F
A
H
P
P
L
S
K
V
G
L
S
E
P
E
A
R
E
R
L
G
-
D
-
V
L
T
V
Y
E
T
S
F
--
T
P
M
R
Y
A
L
--
N
E
----
H
----
G
-
P
K
--
T
A
M
K
L
V
C
-
A
-
G
P
-
E
-
Q
R
V
V
G
V
H
V
I
G
D
G
A
D
E
M
L
Q
G
F
A
V
A
V
K
M
G
A
T
K
A
D
F
D
N
T
V
A
I
H
P
G
S
A
E
E
L
V
T
L
K
-----------
41
PsiBlast_CBE
79.71
38%
-97
- C2 -
2X8G
7
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
PI
G
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQ
K
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
KQLKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
40
PsiBlast_CBE
79.36
38%
-97
- C2 -
2X8H
9
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
PI
G
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQ
K
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
43
PsiBlast_CBE
79.27
38%
-98
- C2 -
2X8C
5
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
PI
G
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQK
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
45
PsiBlast_CBE
79.14
38%
-96
- C2 -
2V6O
6
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
---------
P
I
G
T
T
W
G
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQ
K
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
49
PsiBlast_CBE
79.10
38%
-96
- C2 -
3DGH
5
TRXR1_DROME
A:
[10-474]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
A
G
L
-
A
C
A
K
E
A
V
L
N
-
G
A
R
V
A
C
---
L
---------
D
F
V
K
P
T
--
P
T
---------
L
G
T
K
W
G
-
V
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
-
E
A
A
A
--
Y
G
W
-----
N
-
V
---
D
-
D
K
---
I
KP-
D
W
H
K
L
V
Q
S
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
-------
V
D
--
S
H
--
T
L
L
--
A
K
L
K--
S
---------
G
---------
E
R
----
T
-----
I
T
A
Q
T
F
V
I
A
V
G
G
R
P
R
Y
P
---
D
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
---
K
G
-
L
---
G
Y
E
P
T
V
M
V
R
S
I
V
-
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
--------
E
K
Q
--------
D
D
G
K
L
L
V
---
K
--
Y
K
----
N
---
V
------
E
--
T
G
E
E
S
E
D
V
------
Y
D
T
V
L
W
A
I
G
R
K
G
L
V
D
D
L
N
L
P
N
A
G
V
T
--
V
Q
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
-
I
Y
G
----
K
P
-
E
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
--
Y
G
G
S
T
Q
-
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
K
P
T
E
F
F
I
P
Q
--
K
S
----
V
----
R
-
Y
---
C
Y
L
K
A
V
A
-
E
-
R
H
G
D
-
Q
R
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
T
T
A
E
E
F
T
R
L
------------
48
PsiBlast_CBE
78.79
38%
-96
- C2 -
3DGH
4
TRXR1_DROME
B:
[10-474]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
A
G
L
-
A
C
A
K
E
A
V
L
N
-
G
A
R
V
A
C
---
L
---------
D
FVKPT--
P
T
---------
L
GTKWG-
V
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
-
E
A
A
A
--
Y
G
W
-----
N
-
V
---
D
-
D
K
---
I
KP-
D
W
H
K
L
V
Q
S
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
-------
V
D
--
S
H
--
T
L
L
--
A
KLK--
S
---------
G
---------
E
R----
T
-----
I
T
A
Q
T
F
V
I
A
V
G
G
R
P
R
Y
P
---
D
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
---
K
G
-
L
---
G
Y
E
P
T
V
M
V
R
S
I
V
-
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
--------
E
K
Q
--------
D
D
G
K
L
L
V
---
K
--
Y
K
----
N
---
V
------
E
--
T
GEESE
D
V
------
Y
D
T
V
L
W
A
I
G
R
K
G
L
V
D
D
L
N
L
P
N
A
G
V
T
--
V
Q
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
-
I
Y
G
----
K
P
-
E
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
--
Y
G
G
S
T
Q
-
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
F
F
I
P
Q
--
K
S
----
V
----
R
-
Y
---
C
Y
L
K
A
V
A
-
E
-
R
H
G
D
-
Q
R
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
T
T
A
E
E
F
T
R
L
------------
44
PsiBlast_CBE
78.68
38%
-96
- C2 -
3H4K
6
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
PIG
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQ
K
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
105
HHSearch
78.30
38%
-95
- C2 -
3O0H
4
?
A:
[24-469]
---------------------------------------------------------------------------------------------------
S
F
D
F
D
L
F
V
I
G
S
G
S
G
G
V
-
R
A
A
R
L
A
G
A
L
-
G
K
R
V
A
I
---
A
---------
E
-------
E
Y
---------
R
------
I
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
Y
A
S
Q
Y
A
Q
E
F
S
K
-
S
I
G
--
F
G
W
-----
K
-
Y
A--
D
-
P
I
---
F
---
N
W
E
K
L
V
A
A
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
-
L
-
Q
N
S
N
-
V
H
I
Y
E
S
R
A
V
F
-------
V
D
--
E
H
--
T
L
E
--
L
SV---
T
---------
G
---------
E
-----
R
-----
I
S
A
E
K
I
L
I
A
T
G
A
K
I
V
S
N
-----
I
K
G
S
-
D
L
C
L
T
S
N
E
I
F
D
L
E
K
L
P
K
---------
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
F
---
H
G
-
L
---
G
V
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
--------
Q
S
T
--------
E
N
C
-
Y
N
V
---
V
--
L
T
----
N
---
G
------
Q
--
T
-----
I
C
------
A
D
R
V
M
L
A
T
G
R
V
P
N
T
T
G
L
G
L
E
R
A
G
V
K
V
-
N
E
F
G
A
-
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
-----
V
-
T
-
G
----
H
I
-
Q
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
--
F
E
----
T
T
P
D
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
--
Y
K
-
R
V
E
I
Y
R
T
V
F
--
R
P
M
R
N
V
L
--
S
G
----
S
----
P
-
E
K
--
M
F
M
K
L
V
V
-
D
-
G
E
-
S
-
R
I
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
T
M
S
E
E
L
V
T
M
------------
39
PsiBlast_CBE
78.27
38%
-94
- C2 -
2X99
13
?
A:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
L
D
Y
V
---------
E
-------
P
T
PI
G
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQ
K
V
S
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
K
Q
LKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
38
PsiBlast_CBE
78.20
38%
-97
- C2 -
3O0H
4
?
A:
[27-469]
------------------------------------------------------------------------------------------------------
F
D
L
F
V
I
G
S
G
S
G
G
V
-
R
A
A
R
L
A
G
A
L
-
G
K
R
V
A
I
---
A
---------
E
-------
E
Y
---------
R
------
I
G
G
T
C
V
I
R
G
C
V
P
K
K
L
Y
F
Y
A
S
Q
Y
A
Q
E
F
S
-
K
S
I
G
--
F
G
W
-----
K
Y
A
---
D
-
P
I
---
F
---
N
W
E
K
L
V
A
A
K
N
K
E
I
S
R
L
E
G
L
Y
R
E
G
-
L
-
Q
N
S
N
-
V
H
I
Y
E
S
R
A
V
F
-------
V
D
--
E
H
--
T
L
E
L
S
V
-----
T
---------
G
---------
E
-----
R
-----
I
S
A
E
K
I
L
I
A
T
G
A
K
I
V
S
N
-----
I
K
G
S
-
D
L
C
L
T
S
N
E
I
F
D
L
E
K
L
P
K
---------
S
I
V
I
V
G
G
G
Y
I
G
V
E
F
A
N
I
F
---
H
G
-
L
---
G
V
K
T
T
L
L
H
R
G
D
L
I
L
R
N
F
D
Y
D
L
R
Q
L
L
N
D
A
M
V
A
K
G
I
S
I
I
Y
E
A
T
V
S
Q
V
--------
Q
-
S
--------
T
E
N
C
Y
N
V
---
V
--
L
T
----
N
---
G
------
Q
--
T
-----
I
C
------
A
D
R
V
M
L
A
T
G
R
V
P
N
T
T
G
L
G
L
E
R
A
G
V
K
V
-
N
E
F
G
A
-
V
V
V
D
E
K
M
T
T
N
V
S
H
I
W
A
V
G
D
-----
V
-
T
-
G
----
H
I
-
Q
L
T
P
V
A
I
H
D
A
M
C
F
V
K
N
A
--
F
E
---
T
T
P
-
D
Y
D
L
I
T
T
A
V
F
S
Q
P
E
I
G
T
V
G
L
S
E
E
D
A
L
H
R
Y
K
R
---
V
E
I
Y
R
T
V
F
--
R
P
M
R
N
V
L
--
S
G
----
S
----
P
-
E
K
--
M
F
M
K
L
V
V
-
D
-
G
E
-
S
-
R
I
V
V
G
A
H
V
L
G
E
N
A
G
E
I
A
Q
L
I
G
I
S
L
K
G
K
L
T
K
D
I
F
D
K
T
M
A
V
H
P
T
M
S
E
E
L
V
T
M
------------
103
HHSearch
77.94
46%
-92
- C2 -
1ONF
1
GSHR_PLAFK
A:
[2-496]
-----------------------------------------------------------------------------------------------------
V
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
-
N
A
K
V
A
L
---
V
---------
E
-------
K
S
---------
R
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
N
-
S
R
H
--
Y
G
F
-----
D
-
T
---
K
-
F
S
---
F
---
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
-
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
-------
L
---------------------------------------------------
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
---
P
-
V
K
G
I
-
E
N
T
I
S
S
D
E
F
F
N
I
K
-
E
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
---
K
R
-
L
---
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
--------
K
K
V
--------
S
D
K
N
L
S
I
---
H
--
L
S
----
D
---
G
------
R
--
I
Y
----
E
H
------
F
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
-
N
-
N
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
-----
C
-
C
-
M
VKF
Y
N
V
-
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
L
K
K
T
-
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
-
N
V
K
I
Y
E
S
K
F
--
T
N
L
F
F
S
V
--
Y
D
IEPE
L
----
K
-
E
K
--
T
Y
L
K
L
V
C
-
V
-
G
K
-
D
-
E
L
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
T
A
A
E
E
F
L
T
L
Q
-----------
35
PsiBlast_CBE
77.48
39%
-91
- C2 -
1ZKQ
1
TRXR2_MOUSE
A:
[30-500]
---------------------------------------------------------------------------------------------------
Q
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
L
-
A
C
A
K
E
A
A
Q
L
-
G
K
K
V
A
V
A
D
Y
V
---------
E
-------
P
S
PR
G
T
K
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
-
H
Q
A
A
L
L
G
G
M
I
R
D
A
H
H
--
Y
G
W
-----
E
-
V
AQ-
P
-
V
Q
---
H
---
N
W
K
T
M
A
E
A
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
-
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
-------
V
D
--
E
H
--
T
V
R
--
G
V
D
KG
G
K
---------
A
---------
T
-----
L
-----
L
S
A
E
H
I
V
I
A
T
G
G
R
P
R
Y
P
---
T
Q
V
K
G
A
L
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
T
G
-
I
---
G
L
D
T
T
V
M
M
R
S
-
I
P
L
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
--------
K
K
L
--------
P
T
N
Q
L
Q
V
---
T
--
W
E
----
D
HAS
G
------
K
E
D
T
-----
G
T
------
F
D
T
V
L
W
A
I
G
R
V
P
E
T
R
T
L
N
L
E
K
A
G
I
S
T
N
P
K
N
Q
K
-
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
D
-----
V
-
A
E
G
----
R
P
-
E
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
--
F
-
G
K
S
S
T
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
-
H
V
E
V
Y
H
A
Y
Y
--
K
P
L
E
F
T
V
--
A
D
----
R
D---
A
-
S
Q
--
C
Y
I
K
M
V
C
M
R
-
E
P
-
P
-
Q
L
V
L
G
L
H
F
L
G
P
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
T
C
S
E
E
V
V
K
L
------------
51
PsiBlast_CBE
77.33
36%
-98
- C2 -
4J57
2
TRXR2_PLAF7
B:
[42-519]
------------------------------------------------------------------------------------------------------
Y
D
Y
V
V
I
G
G
G
P
G
G
M
-
A
S
A
K
E
A
A
A
H
-
G
A
R
V
L
L
FDY
V
---------
K
-------
P
S
---------
S
QGTKWG
I
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
A
--
Y
G
W
-----
K
-
F
---
D
N
L
K
---
H
---
D
W
K
K
L
V
T
T
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
-------
K
D
--
K
N
--
T
V
S
YY
L
-----
K
---------
G
---------
D
-----
L
SKEET
V
T
G
K
Y
I
L
I
A
T
G
C
R
P
H
I
P
---
D
D
V
E
G
A
K
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
---
N
S
-
L
---
G
Y
D
V
T
V
A
V
R
S
-
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
--------
T
K
---------
M
D
D
K
I
L
V
---
E
--
F
S
----
D
---
K
------
T
--
S
-----
E
L
------
Y
D
T
V
L
Y
A
I
G
R
K
G
D
I
D
G
L
N
L
E
S
L
N
M
N
V
-
N
K
S
N
N
K
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
V
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
--
F
K
D
S
-
D
E
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
E
F
--
N
N
L
E
I
S
A
--
V
-----
H
----
R
---ST
C
L
A
K
L
V
C
L
K
-
N
E
-
D
-
N
R
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
I
G
I
H
P
T
D
A
E
S
F
M
N
L
------------
50
PsiBlast_CBE
77.15
38%
-96
- C2 -
2NVK
2
TRXR1_DROME
X:
[10-474]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
A
G
L
-
A
C
A
K
E
A
V
L
N
-
G
A
R
V
A
C
---
L
---------
D
FVKPT--
P
T
---------
L
GTKWG-
V
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
-
E
A
A
A
--
Y
G
W
-----
N
-
V
---
D
-
D
K
---
I
KP-
D
W
H
K
L
V
Q
S
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
-------
V
D
--
S
H
--
T
L
L
--
A
KLK--
S
---------
G
---------
E
R----
T
-----
I
T
A
Q
T
F
V
I
A
V
G
G
R
P
R
Y
P
---
D
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
---
K
G
-
L
---
G
Y
E
P
T
V
M
V
R
S
I
V
-
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
--------
E
K
Q
--------
D
D
G
K
L
L
V
---
K
--
Y
K
----
N
---
V
------
E
--
T
GEESE
D
V
------
Y
D
T
V
L
W
A
I
G
R
K
G
L
V
D
D
L
N
L
P
N
A
G
V
T
--
V
Q
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
-
I
Y
G
----
K
P
-
E
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
--
Y
G
G
S
T
Q
-
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
F
F
I
P
Q
--
K
S
----
V
----
R
-
Y
---
C
Y
L
K
A
V
A
-
E
-
R
H
G
D
-
Q
R
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
T
T
A
E
E
F
T
R
L
------------
52
PsiBlast_CBE
77.00
36%
-98
- C2 -
4J57
3
TRXR2_PLAF7
A:
[42-519]
------------------------------------------------------------------------------------------------------
Y
D
Y
V
V
I
G
G
G
P
G
G
M
-
A
S
A
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
Y
V
---------
K
-------
P
S
---------
S
QG
T
K
W
G
I
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
A
--
Y
G
W
-----
K
-
F
---
D
N
L
K
---
H
---
D
W
K
K
L
V
T
T
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
-------
K
D
--
K
N
--
T
V
S
Y
Y
L
-----
K
---------
G
---------
D
-----
L
S
K
E
E
T
V
T
G
K
Y
I
L
I
A
T
G
C
R
P
H
I
P
---
D
D
V
E
G
A
K
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
---
N
S
-
L
---
G
Y
D
V
T
V
A
V
R
S
-
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
--------
T
K
---------
M
D
D
K
I
L
V
---
E
--
F
S
----
D
---
K
------
T
--
S
-----
E
L
------
Y
D
T
V
L
Y
A
I
G
R
K
G
D
I
D
G
L
N
L
E
S
L
N
M
N
V
-
N
K
S
N
N
K
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
V
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
--
F
K
D
S
-
D
E
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
E
F
--
N
N
L
E
I
S
A
--
V
-----
H
----
R
---ST
C
L
A
K
L
V
C
L
K
-
N
E
-
D
-
N
R
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
I
G
I
H
P
T
D
A
E
S
F
M
N
L
------------
122
Fugue
76.65
39%
-91
- C2 -
3H4K
7
?
A:
[6-593]
G
T
S
Q
W
L
R
K
T
V
D
S
AA
V
I
L
F
S
K
TTC
P
Y
C
K
K
V
K
D
V
L
A
E
A
K
I
K
H
A
T
I
ELDQLSN
G
S
A
I
Q
K
C
L
A
S
F
SKIETVP
Q
M
F
V
RGKFIGD
S
Q
T
V
L
K
Y
Y
S
N
DE
L
A
G
I
V
N
E
S
K
Y
D
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
---
L
D
Y
V
E
P
TPIG
T
-------
T
W
---------
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
D
A
E
H
---
F
G
W
-----
S
-
L
---
D
-
R
S
K
I
S
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
T
D
KNQ
K
---------
V
---------
S
-----
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
--------
K
Q
L
KVVDTENN
K
P
G
L
L
L
V
---
K
--
G
H
Y
TDG
K
---
K
------
F
--
E
-----
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
N
A
-
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
-
L
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
H
R---
E
----
D
-
N
V
--
C
Y
M
K
L
V
C
-
R
-
K
S
-
D
N
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
H
VTKKSGVSPIV
46
PsiBlast_CBE
76.39
38%
-95
- C2 -
3DH9
2
TRXR1_DROME
B:
[6-470]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
A
G
L
-
A
C
A
K
E
A
V
L
N
-
G
A
R
V
A
C
---
L
---------
D
FVKPT--
P
T
---------
L
GTKWG-
V
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
-
E
A
A
A
--
Y
G
W
-----
N
-
V
---
D
-
D
K
---
I
KP-
D
W
H
K
L
V
Q
S
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
-------
V
D
--
S
H
--
T
L
L
--
A
KLK--
S
---------
G
---------
E
R----
T
-----
I
T
A
Q
T
F
V
I
A
V
G
G
R
P
R
Y
P
---
D
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
---
K
G
-
L
---
G
Y
E
P
T
V
M
V
R
S
I
V
-
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
--------
E
K
Q
--------
D
D
G
K
L
L
V
---
K
--
Y
K
----
N
---
V
------
E
--
T
GEESE
D
V
------
Y
D
T
V
L
W
A
I
G
R
K
G
L
V
D
D
L
N
L
P
N
A
G
V
T
--
V
Q
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
-
I
Y
G
----
K
P
-
E
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
--
Y
G
G
S
T
Q
-
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
KP
T
E
F
F
I
P
Q
--
K
S
----
V
----
R
-
Y
---
C
Y
L
K
A
V
A
-
E
-
R
H
G
D
-
Q
R
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
T
T
A
E
E
F
T
R
L
------------
34
PsiBlast_CBE
75.90
41%
-90
- C2 -
1ONF
1
GSHR_PLAFK
A:
[3-496]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
M
-
A
A
A
R
R
A
A
R
H
-
N
A
K
V
A
L
---
V
---------
E
-------
K
S
---------
R
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
I
M
F
N
A
A
S
V
H
D
I
L
E
-
N
S
R
H
--
Y
G
F
-----
D
-
T
---
K
-
F
S
---
F
---
N
L
P
L
L
V
E
R
R
D
K
Y
I
Q
R
L
N
N
I
Y
R
Q
N
-
L
-
S
K
D
K
-
V
D
L
Y
E
G
T
A
S
F
-------
L
---------------------------------------------------
E
G
R
N
I
L
I
A
V
G
N
K
P
V
F
P
---
P
-
V
K
G
I
-
E
N
T
I
S
S
D
E
F
F
N
I
K
E
-
S
K
---------
K
I
G
I
V
G
S
G
Y
I
A
V
E
L
I
N
V
I
---
K
R
-
L
---
G
I
D
S
Y
I
F
A
R
G
N
R
I
L
R
K
F
D
E
S
V
I
N
V
L
E
N
D
M
K
K
N
N
I
N
I
V
T
F
A
D
V
V
E
I
--------
K
K
V
--------
S
D
K
N
L
S
I
---
H
--
L
S
----
D
---
G
------
R
--
I
Y
----
E
H
------
F
D
H
V
I
Y
C
V
G
R
S
P
D
T
E
N
L
K
L
E
K
L
N
V
E
T
--
N
N
N
Y
-
I
V
V
D
E
N
Q
R
T
S
V
N
N
I
Y
A
V
G
D
CCMVK--
F
-
Y
----
N
V
-
Q
L
T
P
V
A
I
N
A
G
R
L
L
A
D
R
L
--
F
L
-
K
K
T
R
K
T
N
Y
K
L
I
P
T
V
I
F
S
H
P
P
I
G
T
I
G
L
S
E
E
A
A
I
Q
I
Y
G
K
E
-
N
V
K
I
Y
E
S
K
F
--
T
N
L
F
F
S
V
--
Y
D
IEPE
L
----
K
-
E
K
--
T
Y
L
K
L
V
C
-
V
-
G
K
-
D
-
E
L
I
K
G
L
H
I
I
G
L
N
A
D
E
I
V
Q
G
F
A
V
A
L
K
M
N
A
T
K
K
D
F
D
E
T
I
P
I
H
P
T
A
A
E
E
F
L
T
L
Q
-----------
42
PsiBlast_CBE
75.45
38%
-93
- C2 -
2X8C
3
?
B:
[108-581]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
G
G
L
-
A
A
G
K
E
A
A
K
Y
-
G
A
K
T
A
V
LDY
V
---------
E
-------
P
T
PIGTTW---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
A
L
E
-
D
A
E
H
--
F
G
W
-----
S
-
L
---
D
-
R
S
KIS
H
---
N
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
A
-
L
-
R
D
N
Q
-
V
T
Y
L
N
A
K
G
R
L
-------
I
S
--
P
H
--
E
V
Q
--
I
-----
T
---------
D
---------
K
NQKVS
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
I
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
KQLKVVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
GH
Y
T
----
D
---
G
------
K
--
K
FE---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
V
L
C
E
T
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
T
D
D
E
Q
T
T
V
S
N
V
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
Q
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
K
-
D
I
E
V
Y
H
S
N
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
R
K
-
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
A
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
59
PsiBlast_CBE
75.36
36%
-93
- C2 -
2WBA
8
TYTR_TRYBB
B:
[2-472]
---------------------------------------------------------------------------------------------------
S
K
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
-
G
K
R
V
A
V
---
V
---------
D
VQTSHG-
P
P
---------
F
YAA---
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
-
G
--
F
G
W
-----
E
-
F
---
D
-
G
S
---
S
VKA
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
-------
E
S
--
K
N
--
V
V
V
--
V
-----
R
ETADPKSAV
K
---------
E
-----
R
-----
L
Q
A
D
H
I
L
L
A
T
G
S
W
P
Q
M
P
---
A
-
I
P
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
---
N
A
-
Y
KPP
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
--------
S
L
N
--------
T
D
G
S
K
H
V
---
T
--
F
E
----
S
---
G
------
K
--
T
-----
L
D
------
V
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
-
T
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
L
-
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
--
F
G
N
K
P
R
-
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
L
M
H
N
I
--
S
G
----
S
----
K
Y
K
K
--
F
V
A
K
I
V
T
-
N
-
H
S
-
D
-
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
58
PsiBlast_CBE
74.95
36%
-99
- C2 -
4B1B
1
TRXR_PLAF5
A:
[43-506]
------------------------------------------------------------------------------------------------------
Y
D
Y
V
V
I
G
G
G
P
G
G
M
-
A
S
A
K
E
A
A
A
H
-
G
A
R
V
L
L
F
D
Y
V
---------
K
-------
P
S
---------
S
QG
T
K
W
G
I
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
A
--
Y
G
W
-----
K
-
F
---
D
N
L
K
---
H
---
D
W
K
K
L
V
T
T
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
-------
K
D
--
K
N
--
T
V
S
Y
Y
L
-----
K
-------------------------
L
S
K
E
E
T
V
T
G
K
Y
I
L
I
A
T
G
C
R
P
H
I
P
---
D
D
V
E
G
A
K
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
---
N
S
-
L
---
G
Y
D
V
T
V
A
V
R
S
-
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
--------
T
K
---------
M
D
D
K
I
L
V
---
E
--
F
S
----
D
---
K
------
T
--
S
-----
E
L
------
Y
D
T
V
L
Y
A
I
G
R
K
G
D
I
D
G
L
N
L
E
S
L
N
M
N
V
-
N
K
S
N
N
K
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
V
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
--
F
K
D
S
-
D
E
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
----------------------------T-
C
L
A
K
L
V
C
L
K
-
N
E
-
D
-
N
R
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
--------------------------
47
PsiBlast_CBE
74.73
38%
-96
- C2 -
3DH9
2
TRXR1_DROME
A:
[6-470]
------------------------------------------------------------------------------------------------------
Y
D
L
I
V
I
G
G
G
S
A
G
L
-
A
C
A
K
E
A
V
L
N
-
G
A
R
V
A
C
---
L
---------
D
F
V
K
P
T--
P
T
---------
L
G
T
K
W
G
-
V
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
S
L
L
G
E
A
V
H
-
E
A
A
A
--
Y
G
W
-----
N
-
V
---
D
-
D
K
---
I
KP-
D
W
H
K
L
V
Q
S
V
Q
N
H
I
K
S
V
N
W
V
T
R
V
D
-
L
-
R
D
K
K
-
V
E
Y
I
N
G
L
G
S
F
-------
V
D
--
S
H
--
T
L
L
--
A
K
L
K--
S
---------
G
---------
E
R
----
T
-----
I
T
A
Q
T
F
V
I
A
V
G
G
R
P
R
Y
P
---
D
-
I
P
G
A
V
E
Y
G
I
T
S
D
D
L
F
S
L
D
R
E
P
G
---------
K
T
L
V
V
G
A
G
Y
I
G
L
E
C
A
G
F
L
---
K
G
-
L
---
G
Y
E
P
T
V
M
V
R
S
I
V
-
L
R
G
F
D
Q
Q
M
A
E
L
V
A
A
S
M
E
E
R
G
I
P
F
L
R
K
T
V
P
L
S
V
--------
E
K
Q
--------
D
D
G
K
L
L
V
---
K
--
Y
K
----
N
---
V
------
E
--
T
G
E
E
S
E
D
V
------
Y
D
T
V
L
W
A
I
G
R
K
G
L
V
D
D
L
N
L
P
N
A
G
V
T
--
V
Q
K
D
K
-
I
P
V
D
S
Q
E
A
T
N
V
A
N
I
Y
A
V
G
D
-----
I
-
I
Y
G
----
K
P
-
E
L
T
P
V
A
V
L
A
G
R
L
L
A
R
R
L
--
Y
G
G
S
T
Q
-
R
M
D
Y
K
D
V
A
T
T
V
F
T
P
L
E
Y
A
C
V
G
L
S
E
E
D
A
V
K
Q
F
G
A
D
-
E
I
E
V
F
H
G
Y
Y
K
P
T
E
F
F
I
P
Q
--
K
S
----
V
----
R
-
Y
---
C
Y
L
K
A
V
A
-
E
-
R
H
G
D
-
Q
R
V
Y
G
L
H
Y
I
G
P
V
A
G
E
V
I
Q
G
F
A
A
A
L
K
S
G
L
T
I
N
T
L
I
N
T
V
G
I
H
P
T
T
A
E
E
F
T
R
L
------------
60
PsiBlast_CBE
74.61
36%
-91
- C2 -
2WBA
9
TYTR_TRYBB
A:
[2-472]
---------------------------------------------------------------------------------------------------
S
K
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
-
G
K
R
V
A
V
---
V
---------
D
VQTSHG-
P
P
---------
F
YAA---
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
-
G
--
F
G
W
-----
E
-
F
---
D
-
G
S
---
S
V
K
A
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
-------
E
S
--
K
N
--
V
V
V
--
V
-----
R
ETADPKSAV
K
---------
E
-----
R
-----
L
Q
A
D
H
I
L
L
A
T
G
S
W
P
Q
M
P
---
A
-
I
P
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
---
N
A
-
Y
KPP
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
--------
S
L
N
--------
T
D
G
S
K
H
V
---
T
--
F
E
----
S
---
G
------
K
--
T
-----
L
D
------
V
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
-
T
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
L
-
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
--
F
G
N
K
P
R
-
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
L
M
H
N
I
--
S
G
----
S
----
K
Y
K
K
--
F
V
A
K
I
V
T
-
N
-
H
S
-
D
-
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
61
PsiBlast_CBE
74.59
36%
-93
- C2 -
4NEV
10
?
B:
[6-475]
----------------------------------------------------------------------------------------------------
K
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
-
G
K
R
V
A
V
---
V
---------
D
VQT
S
H
G
-
P
P
---------
F
YAA---
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
-
G
--
F
G
W
-----
E
-
F
---
D
-
G
S
---
S
V
K
A
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
-------
E
S
--
K
N
--
V
V
V
--
V
-----
R
ETADPKSAV
K
---------
E
-----
R
-----
L
Q
A
D
H
I
L
L
A
T
G
S
W
P
Q
M
P
---
A
-
I
P
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
---
N
A
-
Y
KPP
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
--------
S
L
N
--------
T
D
G
S
K
H
V
---
T
--
F
E
----
S
---
G
------
K
--
T
-----
L
D
------
V
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
-
T
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
L
-
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
--
F
G
N
K
P
-
R
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
L
M
H
N
I
--
S
G
----
S
----
K
Y
K
K
--
F
V
A
K
I
V
T
-
N
-
H
S
-
D
-
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
36
PsiBlast_CBE
74.37
39%
-88
- C2 -
1ZDL
2
TRXR2_MOUSE
A:
[31-500]
----------------------------------------------------------------------------------------------------
Q
S
F
D
L
L
V
I
G
G
G
S
G
G
L
-
A
C
A
K
E
A
A
Q
L
-
G
K
K
V
A
V
A
D
Y
V
---------
E
-------
P
S
PRG
T
K
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
-
H
Q
A
A
L
L
G
G
M
I
R
D
A
H
H
--
Y
G
W
-----
E
-
V
AQ-
P
-
V
Q
---
H
---
N
W
K
T
M
A
E
A
V
Q
N
H
V
K
S
L
N
W
G
H
R
V
Q
-
L
-
Q
D
R
K
-
V
K
Y
F
N
I
K
A
S
F
-------
V
D
--
E
H
--
T
V
R
--
G
V
D
KG
G
K
---------
A
---------
T
-----
L
-----
L
S
A
E
H
I
V
I
A
T
G
G
R
P
R
Y
P
---
T
Q
V
K
G
A
L
E
Y
G
I
T
S
D
D
I
F
W
L
K
E
S
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
A
G
F
L
---
T
G
-
I
---
G
L
D
T
T
V
M
M
R
S
-
I
P
L
R
G
F
D
Q
Q
M
S
S
L
V
T
E
H
M
E
S
H
G
T
Q
F
L
K
G
C
V
P
S
H
I
--------
K
K
L
--------
P
T
N
Q
L
Q
V
---
T
--
W
E
----
D
HAS
G
------
K
E
D
T
-----
G
T
------
F
D
T
V
L
W
A
I
G
R
V
P
E
T
R
T
L
N
L
E
K
A
G
I
S
T
N
P
K
N
Q
K
-
I
I
V
D
A
Q
E
A
T
S
V
P
H
I
Y
A
I
G
D
-----
V
-
A
E
G
----
R
P
-
E
L
T
P
T
A
I
K
A
G
K
L
L
A
Q
R
L
--
F
-
G
K
S
S
T
L
M
D
Y
S
N
V
P
T
T
V
F
T
P
L
E
Y
G
C
V
G
L
S
E
E
E
A
V
A
L
H
G
Q
E
-
H
V
E
V
Y
H
A
Y
Y
--
K
P
L
E
F
T
V
--
A
D
----
R
D---
A
-
S
Q
--
C
Y
I
K
M
V
C
M
R
-
E
P
-
P
-
Q
L
V
L
G
L
H
F
L
G
P
N
A
G
E
V
T
Q
G
F
A
L
G
I
K
C
G
A
S
Y
A
Q
V
M
Q
T
V
G
I
H
P
T
C
S
E
E
V
V
K
L
------------
98
PsiBlast_CBE
74.20
36%
-94
- C2 -
4APN
7
?
A:
[21-492]
--------------------------------------------------------------------------------------------------
M
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
-
K
K
K
V
A
V
---
V
---------
D
VQA
T
H
G
P
P
L
---------
F
AA----
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
---
M
D
L
I
R
E
S
G
G
F
G
W
-----
E
-
M
---
D
-
R
E
---
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
-------
Q
D
--
A
H
--
T
V
V
--
V
-----
R
---------
K
SEDPHSDVL
E
-----
T
-----
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
---
G
-
V
P
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
-
C
---
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
--------
T
K
N
--------
E
D
G
S
N
H
V
---
H
--
F
N
----
D
---
G
------
T
--
E
-----
E
D
------
Y
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
-
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
H
N
I
S
G
S
K
----
H
----
K
-
E
---
F
M
I
R
I
I
T
-
N
-
E
S
-
N
-
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
111
HHSearch
73.97
36%
-91
- C2 -
1FEC
2
TYTR_CRIFA
A:
[1-470]
---------------------------------------------------------------------------------------------------
S
R
A
Y
D
L
V
V
I
G
A
G
S
G
G
L
-
E
A
G
W
N
A
A
S
L
H
K
K
R
V
A
V
---
I
---------
D
-------
L
Q
KHHGPPHYA
A
------
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
N
Y
M
D
T
I
R
E
-
S
A
G
--
F
G
W
-----
E
-
L
DRE
S
-
V
R
---
P
---
N
W
K
A
L
I
A
A
K
N
K
A
V
S
G
I
N
D
S
Y
E
G
M
F
A
-
D
T
E
G
-
L
T
F
H
Q
G
F
G
A
L
-------
Q
D
--
N
H
--
T
V
L
--
V
-----
R
ESADPNSAV
L
---------
E
-----
T
-----
L
D
T
E
Y
I
L
L
A
T
G
S
W
P
Q
H
L
---
G
-
I
E
G
D
-
D
L
C
I
T
S
N
E
A
F
Y
L
D
E
A
P
K
---------
R
A
L
C
V
G
G
G
Y
I
S
I
E
F
A
G
I
F
---
N
A
-
Y
KAR
G
G
Q
V
D
L
A
Y
R
G
D
M
I
L
R
G
F
D
S
E
L
R
K
Q
L
T
E
Q
L
R
A
N
G
I
N
V
R
T
H
E
N
P
A
K
V
--------
T
K
N
--------
A
D
G
T
R
H
V
---
V
--
F
E
----
S
---
G
------
A
--
E
-----
A
D
------
Y
D
V
V
M
L
A
I
G
R
V
P
R
S
Q
T
L
Q
L
E
K
A
G
V
E
V
-
A
K
N
G
A
-
I
K
V
D
A
Y
S
K
T
N
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
D
----
R
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
D
T
V
--
F
A
N
K
P
-
R
A
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
M
G
V
C
G
Y
V
E
E
D
A
A
K
K
Y
--
D
-
Q
V
A
V
Y
E
S
S
F
--
T
P
L
M
H
N
I
--
S
G
S---
T
----
Y
-
K
K
--
F
M
V
R
I
V
T
-
N
-
H
A
-
D
-
G
E
V
L
G
V
H
M
L
G
D
S
S
P
E
I
I
Q
S
V
A
I
C
L
K
M
G
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
------------
99
PsiBlast_CBE
73.60
36%
-94
- C2 -
4ADW
5
?
B:
[21-492]
--------------------------------------------------------------------------------------------------
M
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
-
K
K
K
V
A
V
---
V
---------
D
VQATHGP
P
L
---------
F
AA----
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
---
M
D
L
I
R
E
S
GG
F
G
W
-----
E
-
M
---
D
-
R
E
---
S
LCP
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
-------
Q
D
--
A
H
--
T
V
V
--
V
-----
R
---------
K
SEDPHSDVL
E
-----
T
-----
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
---
G
-
V
P
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
NGY
K
P
-
C
---
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
--------
T
K
N
--------
E
D
G
S
N
H
V
---
H
--
F
N
----
D
---
G
------
T
--
E
-----
E
D
------
Y
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
-
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
H
N
I
SG
S
K
----
H
----
K
-
E
---
F
M
I
R
I
I
T
-
N
-
E
S
-
N
-
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
100
PsiBlast_CBE
73.12
36%
-94
- C2 -
4ADW
5
?
A:
[21-492]
--------------------------------------------------------------------------------------------------
M
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
-
K
K
K
V
A
V
---
V
---------
D
VQATHGP
P
L
---------
F
AA----
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
---
M
D
L
I
R
E
S
G
G
F
G
W
-----
E
-
M
---
D
-
R
E
---
S
L
C
P
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
-------
Q
D
--
A
H
--
T
V
V
--
V
-----
R
---------
K
SEDPHSDVL
E
-----
T
-----
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
---
G
-
V
P
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
N
G
Y
K
P
-
C
---
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
--------
T
K
N
--------
E
D
G
S
N
H
V
---
H
--
F
N
----
D
---
G
------
T
--
E
-----
E
D
------
Y
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
-
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
H
N
I
S
G
S
K
----
H
----
K
-
E
---
F
M
I
R
I
I
T
-
N
-
E
S
-
N
-
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
97
PsiBlast_CBE
72.26
36%
-91
- C2 -
4APN
7
?
B:
[21-492]
--------------------------------------------------------------------------------------------------
M
S
R
A
Y
D
L
V
V
L
G
A
G
S
G
G
L
E
A
G
W
N
A
A
V
T
H
-
K
K
K
V
A
V
---
V
---------
D
VQATHGP
P
L
---------
F
AA----
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
---
M
D
L
I
R
E
S
GG
F
G
W
-----
E
-
M
---
D
-
R
E
---
S
LCP
N
W
K
T
L
I
A
A
K
N
K
V
V
N
S
I
N
E
S
Y
K
S
M
-
F
A
D
T
E
G
-
L
S
F
H
M
G
F
G
A
L
-------
Q
D
--
A
H
--
T
V
V
--
V
-----
R
---------
K
SEDPHSDVL
E
-----
T
-----
L
D
T
E
Y
I
L
I
A
T
G
S
W
P
T
R
L
---
G
-
V
P
G
D
-
E
F
C
I
T
S
N
E
A
F
Y
L
E
D
A
P
K
---------
R
M
L
C
V
G
G
G
Y
I
A
V
E
F
A
G
I
F
NGY
K
P
-
C
---
G
G
Y
V
D
L
C
Y
R
G
D
L
I
L
R
G
F
D
T
E
V
R
K
S
L
T
K
Q
L
G
A
N
G
I
R
V
R
T
N
L
N
P
T
K
I
--------
T
K
N
--------
E
D
G
S
N
H
V
---
H
--
F
N
----
D
---
G
------
T
--
E
-----
E
D
------
Y
D
Q
V
M
L
A
I
G
R
V
P
R
S
Q
A
L
Q
L
D
K
A
G
V
R
T
-
G
K
N
G
A
-
V
Q
V
D
A
Y
S
K
T
S
V
D
N
I
Y
A
I
G
D
-----
V
-
T
-
N
----
R
V
-
M
L
T
P
V
A
I
N
E
G
A
A
F
V
E
T
V
--
F
G
G
K
P
R
A
-
T
D
H
T
K
V
A
C
A
V
F
S
I
P
P
I
G
T
C
G
M
T
E
E
E
A
A
K
N
Y
--
E
-
T
V
A
V
Y
A
S
S
F
--
T
P
L
M
H
N
I
SG
S
K
----
H
----
K
-
E
---
F
M
I
R
I
I
T
-
N
-
E
S
-
N
-
G
E
V
L
G
V
H
M
L
G
D
S
A
P
E
I
I
Q
S
V
G
I
C
M
K
M
G
A
K
I
S
D
F
H
S
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
57
PsiBlast_CBE
72.09
36%
-98
- C2 -
4B1B
1
TRXR_PLAF5
B:
[43-506]
------------------------------------------------------------------------------------------------------
Y
D
Y
V
V
I
G
G
G
P
G
G
M
-
A
S
A
K
E
A
A
A
H
-
G
A
R
V
L
L
FDY
V
---------
K
-------
P
S
---------
S
QGTKWG
I
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
H
Y
A
G
H
M
G
S
I
F
K
L
D
S
K
A
--
Y
G
W
-----
K
-
F
---
D
N
L
K
---
H
---
D
W
K
K
L
V
T
T
V
Q
S
H
I
R
S
L
N
F
S
Y
M
T
G
-
L
-
R
S
S
K
-
V
K
Y
I
N
G
L
A
K
L
-------
K
D
--
K
N
--
T
V
S
YY
L
-----
K
-------------------------
L
SKEET
V
T
G
K
Y
I
L
I
A
T
G
C
R
P
H
I
P
---
D
D
V
E
G
A
K
E
L
S
I
T
S
D
D
I
F
S
L
K
K
D
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
E
C
S
G
F
L
---
N
S
-
L
---
G
Y
D
V
T
V
A
V
R
S
-
I
V
L
R
G
F
D
Q
Q
C
A
V
K
V
K
L
Y
M
E
E
Q
G
V
M
F
K
N
G
I
L
P
K
K
L
--------
T
K
---------
M
D
D
K
I
L
V
---
E
--
F
S
----
D
---
K
------
T
--
S
-----
E
L
------
Y
D
T
V
L
Y
A
I
G
R
K
G
D
I
D
G
L
N
L
E
S
L
N
M
N
V
-
N
K
S
N
N
K
I
I
A
D
H
L
S
C
T
N
I
P
S
I
F
A
V
G
D
-----
V
-
A
-
E
----
N
V
P
E
L
A
P
V
A
I
K
A
G
E
I
L
A
R
R
L
--
F
K
D
S
-
D
E
I
M
D
Y
S
Y
I
P
T
S
I
Y
T
P
I
E
Y
G
A
C
G
Y
S
E
E
K
A
Y
E
L
Y
G
K
S
-
N
V
E
V
F
L
Q
----------------------------T-
C
L
A
K
L
V
C
L
K
-
N
E
-
D
-
N
R
V
I
G
F
H
Y
V
G
P
N
A
G
E
V
T
Q
G
M
A
L
A
L
R
L
K
V
K
K
K
D
F
D
N
C
--------------------------
62
PsiBlast_CBE
71.55
36%
-92
- C2 -
4NEV
7
?
A:
[7-475]
-----------------------------------------------------------------------------------------------------
A
F
D
L
V
V
I
G
A
G
S
G
G
L
E
A
G
W
N
A
A
T
L
Y
-
G
K
R
V
A
V
---
V
---------
D
VQT
S
H
G
-
P
P
---------
F
YAA---
L
G
G
T
C
V
N
V
G
C
V
P
K
K
L
M
V
T
G
A
Q
Y
M
D
H
L
R
E
S
A
-
G
--
F
G
W
-----
E
-
F
---
D
-
G
S
---
S
VKA
N
W
K
K
L
I
A
A
K
N
E
A
V
L
D
I
N
K
S
Y
E
G
M
-
F
N
D
T
E
G
-
L
D
F
F
L
G
W
G
S
L
-------
E
S
--
K
N
--
V
V
V
--
V
-----
R
ETADPKSAV
K
---------
E
-----
R
-----
L
Q
A
D
H
I
L
L
A
T
G
S
W
P
Q
M
P
---
A
-
I
P
G
I
-
E
H
C
I
S
S
N
E
A
F
Y
L
P
E
P
P
R
---------
R
V
L
T
V
G
G
G
F
I
S
V
E
F
A
G
I
F
---
N
A
-
Y
KPP
G
G
K
V
T
L
C
Y
R
N
N
L
I
L
R
G
F
D
E
T
I
R
E
E
V
T
K
Q
L
T
A
N
G
I
E
I
M
T
N
E
N
P
A
K
V
--------
S
L
N
--------
T
D
G
S
K
H
V
---
T
--
F
E
----
S
---
G
------
K
--
T
-----
L
D
------
V
D
V
V
M
M
A
I
G
R
I
P
R
T
N
D
L
Q
L
G
N
V
G
V
K
L
-
T
P
K
G
G
-
V
Q
V
D
E
F
S
R
T
N
V
P
N
I
Y
A
I
G
D
-----
I
-
T
-
D
----
R
L
-
M
L
T
P
V
A
I
N
E
G
A
A
L
V
D
T
V
--
F
G
N
K
P
-
R
K
T
D
H
T
R
V
A
S
A
V
F
S
I
P
P
I
G
T
C
G
L
I
E
E
V
A
A
K
E
F
--
E
-
K
V
A
V
Y
M
S
S
F
--
T
P
L
M
H
N
I
--
S
G
----
S
----
K
Y
K
K
--
F
V
A
K
I
V
T
-
N
-
H
S
-
D
-
G
T
V
L
G
V
H
L
L
G
D
G
A
P
E
I
I
Q
A
V
G
V
C
L
R
L
N
A
K
I
S
D
F
Y
N
T
I
G
V
H
P
T
S
A
E
E
L
C
S
M
R
-----------
96
PsiBlast_CBE
70.44
38%
-96
- C2 -
4LA1
2
?
A:
[132-587]
-------------------------------------------------------------------------------------------------------------------------
A
A
K
Y
-
G
A
K
I
A
V
L
D
Y
V
---------
E
-------
P
T
PMG
T
T
W
---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
S
L
E
-
D
A
Q
H
--
F
G
W
-----
S
-
L
---
D
-
K
S
E
I
S
H
---
D
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
S
-
L
-
R
D
N
A
-
V
T
Y
L
N
A
R
G
M
L
LSPH
E
V
Q
I
T
--
E
K
--
N
K
K
--
V
-----
S
-------------------------
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
Y
P
---
E
-
I
P
G
A
I
E
Y
G
I
T
S
D
D
L
F
S
L
P
Y
F
P
G
---------
K
T
L
V
V
G
A
S
Y
V
A
L
K
C
A
G
F
L
---
A
S
-
L
---
G
G
D
V
T
V
M
V
R
S
-
I
L
L
R
G
F
D
Q
Q
M
A
E
K
V
G
D
Y
M
E
N
H
G
V
K
F
A
K
L
C
V
P
D
E
I
T
Q
LKPVDT
E
N
N
--------
K
P
G
L
L
L
V
---
K
G
H
Y
T
----
D
---
G
------
K
--
K
F
E
---
E
E
------
F
E
T
V
I
F
A
V
G
R
E
P
Q
L
S
K
L
N
C
E
A
V
G
V
K
L
-
D
K
N
G
R
-
V
V
C
S
D
D
E
Q
T
T
V
S
N
I
Y
A
I
G
D
-----
I
-
N
A
G
----
K
P
-
Q
L
T
P
V
A
I
H
A
G
R
Y
L
A
R
R
L
--
F
A
G
A
T
E
L
-
T
D
Y
S
N
V
A
T
T
V
F
T
P
L
E
Y
G
A
C
G
L
S
E
E
D
A
I
E
K
Y
G
D
N
-
D
I
E
V
Y
H
S
H
F
--
K
P
L
E
W
T
V
--
A
-----
H
----
R
-
E
D
NV
C
Y
M
K
L
V
C
-
R
I
S
D
-
N
-
M
R
V
L
G
L
H
V
L
G
P
N
A
G
E
I
T
Q
G
Y
A
V
A
I
K
M
G
A
T
K
E
D
F
D
R
T
I
G
I
H
P
T
C
S
E
T
F
T
T
L
------------
95
PsiBlast_CBE
69.07
38%
-94
- C2 -
4LA1
2
?
B:
[132-587]
-------------------------------------------------------------------------------------------------------------------------
A
A
K
Y
-
G
A
K
I
A
V
LDY
V
---------
E
-------
P
T
PMGTTW---
G
------
L
G
G
T
C
V
N
V
G
C
I
P
K
K
L
M
H
Q
A
G
L
L
S
H
S
L
E
-
D
A
Q
H
--
F
G
W
-----
S
-
L
---
D
-
K
S
EIS
H
---
D
W
S
T
M
V
E
G
V
Q
S
H
I
G
S
L
N
W
G
Y
K
V
S
-
L
-
R
D
N
A
-
V
T
Y
L
N
A
R
G
M
L
LSPHEVQ
I
T
--
E
K
--
N
K
K
--
V
-----
S
-------------------------
T
-----
I
T
G
N
K
I
I
L
A
T
G
E
R
P
K
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------------