@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1246: (2016-03-22 )
MNNLKLSEEIKRAINELGYTEATPVQKAVIPVALTGEDIVAKSQTGSGKTAAFAIPIAEQVEWEENKPQALIIVPTRELAMQVKTECTNIGRFKRVKAAAIYGQSPFAKQKLELSQKNHIVVGTPGRLLDHIEKGSLNVDKVAHLVLDEVDEMLSMGFIDQVEDILSRLPKQRQNLFFSATMPEEMQDLIKRYQDNPMVIEMASEKTNPIFHVEMQTDNKEKTLKDVLITENPDSAIIFCNTKNQVDELTDLLDVKASKIHGGLRQEDRFRAMDDFKSGKSRFLIATDVAGRGIDVDNVSLVINYDLPIEKENYVHRIGRTGRAGKSGKAISFVKTNENPLLRDIEEMLDVTIEKKRKPTVIEVKVNEDAFRKKQQKRPTIKKARGEKLNKNIMKLYFNGGKKKKIRAVDFVGTISKLEGITAEDIGIITIEDHVSFVEILNGKGPAVLEMMRSRKVKGRRLKVNEARKR
Atome Classification :
(58 SA)
.........10........20.....-...30....--.--.-.--.40........50........---60----------...------------------.-----.--------..-.----70.........80........90-----.----.-.----.---..-..100.....--..110.-.-...--.--.120.......130-.--.-.-....140.-........150..-.--.-...160...-...--.----170--.-------.--.-------......180....----...190.-------------.----------------------.....200---.------.-----.-----..------.----.---.---.210---.----.----.--.-.-.--.-..220---..----......-230-----....-....240-.......----250-.---..---.------...---..260-.........270.......280.......290.......300.......------310-----........320.......330...-...-.-340.......350......-.360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNNL
K
L
S
E
E
I
K
R
A
I
N
ELGYTEATPVQ-
K
A
V
I
P
V
A
LT--G--E-
D
--
I
V
AKSQTGSGK
T
A
A
F
A
IP
I
A
E
---QV----------EWE------------------E-----N--------KP-
Q
----
A
-
L
I
I
V
P
T
R
E
L
A
M
Q
V
K
T
ECTNIG-----R----
F
-
K
----
R
---
V
K
-
A
A
A
IYGQSPF--
A
K
Q
K
L
E-L-SQK--N--
H
I
V
VGT
P
G
R
L
L
D
H
I
-
E
--K-G-SL
N
V
D
--
K
-
V
A
H
L
V
L
D
E
V
D
E
M
L
-S--M-G
F
I
D
Q
V
E
D
I
-
L
S
R
--
L
----
P
----
K
-------
Q
--
R
-------
Q
N
L
F
FSATM
P
E
E
M
----
Q
D
L
I
K
R
Y-------------Q----------------------DN
P
M
V
I
-----
E
------M-----A-----SE------K----T---N---
P
I
-----
F
----
H
----
V
--
E
-M-Q--T-DNKE----K
T
----
L
K
D
V
L
I
-T-E-----NPD
S
-
A
I
I
F
CNT-KN
Q
V
D
E
L
----
T
---
D
---
L
L
---
D
------
V
K
A
---
S
K
I---HGGLR
Q
E
D
R
F
R
A
M
D
D
FKSGK
S
R
F
L
I
A
TDVAGRGIDVD
N
V
S
L
V
I
N
YDLPI------EK------
E
N
Y
V
H
R
IGRTGRAGKSG
K
A
I
S
F
V
K-TNE-
N
-
P
L
L
R
D
I
E
E
M
L
D
V
T
I
EKKRK-
P
T
V
I
E
V
K
VN
E
D
A
F
R
K
K
Q
QKRP
T
I
K
K
A
R
G
E
K
L
N
K
N
I
M
K
L
YFNGGK
K
K
K
I
R
A
V
D
F
V
G
T
I
S
K
LEGITAE
D
I
G
I
I
T
I
E
DH
V
S
F
V
E
I
LNGK
G
P
A
V
L
E
M
M
R
SRKVKG
R
R
L
KVNEARKR
109
HHSearch
87.14
45%
-89
- C6 -
1HV8
5
H669_METJA
A:
[8-364]
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
-
M
K
V
I
P
L
F
L
N
--
D
E-
Y
-
N
--
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
----------
N
E
-------------------
N
-----
N
--------
G
I
-
E
----
A
-
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
-----
G
----
N
-
K
----
N
---
L
K
-
I
A
K
I
Y
G
G
K
A
I
--
Y
P
Q
I
K
--
A
-
L
K
N
--
A
--
N
I
V
V
G
T
P
G
R
I
L
D
H
I
-
N
--
R
-
G
-
T
L
N
L
K
--
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
--
M
-
G
F
I
K
D
V
E
K
I
-
L
N
A
--
C
----
N
----
K
-------
D
--
K
-------
R
I
L
L
F
S
A
T
M
P
R
E
I
----
L
N
L
A
K
K
Y
-------------
M
----------------------
G
D
Y
S
F
I
-----
K
------
A
-----
K
-----
I
N
------
A
----
N
---
I
---
E
Q
-----
S
----
Y
----
V
--
E
-
V
-
N
--
E
-
N
E
R
F
----
E
A
----
L
C
R
L
L
K
---
N
-----
K
E
F
Y
-
G
L
V
F
C
K
T
-
K
R
D
T
K
E
L
----
A
---
S
---
M
L
---
R
D
I
G---
F
K
A
---
G
A
I
---
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
-
R
R
E
-
Y
-
K
K
L
R
Y
I
E
R
A
M
K
L
K
I
K
K
L
-------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.02
37%
-97
- C6 -
2I4I
1
DDX3X_HUMAN
A:
[17-415]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
------------------
E
-----
N
GRYGRR
K
Q
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
E
Y
I
F
L
-----
A
------
V
-----
G
T----
S
E
------
N
I
---
T
---
Q
---
K
V
-----
V
----
W
----
V
--
E
------
E
-
S
D
K
R
----
S
F
----
L
L
D
L
L
N
-
A
-
T
-----
G
K
D
S
L
T
L
V
F
V
E
T
-
K
K
G
A
D
S
L
----
E
---
D
---
F
L
Y
H
E
G
------
Y
A
C
---
T
S
I
---
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-
E
R
N
-
I
-
N
I
T
K
D
---
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
E
H
H
Y
---------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
85.57
37%
-84
- C6 -
4PXA
6
DDX3X_HUMAN
A:
[67-461]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
Y
S
DGPG
E
A
L
R
A
M
K
------------------
E
-----
N
GRYGRR
K
Q
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
E
Y
I
F
L
-----
A
------
V
-----
G
RVGST
S
E
------
N
I
---
T
---
Q
---
K
V
-----
V
----
W
----
V
--
E
------
E
-
S
D
K
R
----
S
F
----
L
L
D
L
L
N
-
A
-
T
-----
G
K
D
S
L
T
L
V
F
V
E
T
-
K
K
G
A
D
S
L
----
E
---
D
---
F
L
Y
H
E
G
------
Y
A
C
---
T
S
I
---
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
N
-
E
R
N
-
I
-
N
I
T
K
D
---
L
L
D
L
L
V
E
A
K
Q
E
V
P
S
W
L
E
N
M
A
Y
-------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.46
44%
-91
- C6 -
1HV8
5
H669_METJA
A:
[8-354]
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
-
M
K
V
I
P
L
F
L
N
--
D
--
E
Y
N
--
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
---
L
V
----------
N
-
E
------------------
N
-----
N
--------
G
I
-
E
----
A
-
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
-----
G
----
N
-
K
----
N
---
L
K
-
I
A
K
I
Y
G
G
K
A
I
--
Y
P
Q
I
K
A
-
L
-
K
N
A
--
N
---
I
V
V
G
T
P
G
R
I
L
D
H
I
-
N
--
R
-
G
-
T
L
N
L
K
--
N
-
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
--
M
-
G
F
I
K
D
V
E
K
I
-
L
N
A
--
C
----
N
----
K
-------
D
--
K
-------
R
I
L
L
F
S
A
T
M
P
R
E
I
----
L
N
L
A
K
K
Y
-------------
M
----------------------
G
D
Y
S
F
I
-----
K
------
A
-----
K
-----
I
N
------
A
----
N
---
I
---
E
Q
-----
S
----
Y
----
V
--
E
-
V
-
N
--
E
-
N
E
R
F
----
E
A
----
L
C
R
-
L
L
-
K
-
N
-----
K
E
F
Y
-
G
L
V
F
C
K
T
-
K
R
D
T
K
E
L
----
A
---
S
---
M
L
R
D
I
G
------
F
K
A
---
G
A
I
---
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
N
-
R
R
E
-
Y
-
K
K
L
R
Y
I
E
-----------------------------------------------------------------------------------------------------------------------------
113
HHSearch
84.20
39%
-90
- C6 -
2I4I
1
DDX3X_HUMAN
A:
[17-394]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
----------
Y
S
D
GPG
E
A
L
R
A
M
K
E
NGRYGRR
K
-----
Q
--------
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
--
D
TMPP
K
----
G
-------
V
--
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
E
Y
I
F
L
-----
A
------
V
-----
G
-------------
T
----
S
---
E
---
N
I
-----
T
----
Q
K
V
--
V
--
W
-
V
-
E
--
E
-
S
D
K
R
----
S
F
----
L
L
D
L
L
N
-
A
T
G
-----
K
D
S
L
-
T
L
V
F
V
E
T
-
K
K
G
A
D
S
L
----
E
---
D
---
F
L
---
Y
H
E
G---
Y
A
C
---
T
S
I
---
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
N
-
E
R
N
-
I
-
N
I
T
K
D
L
L
D
L
---------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.77
37%
-92
- C6 -
4CT4
2
DDX6_HUMAN
D:
[12-367]
-----
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
-
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
----------
D
L
K
------------------
K
-----
D
--------
N
I
-
Q
----
A
-
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
-----
K
H---
M
-
G
----
G
---
A
K
-
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
-
L
-
D
D
T
--
V
--
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
--
K
-
G
-
V
A
K
V
D
--
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
L
T
--
L
----
P
----
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
----
Q
K
F
M
N
S
H
-------------
L
----------------------
Q
K
P
Y
E
I
-----
N
------
L
-----
M
-----
E
E
------
L
----
T
LKG
V
---
T
Q
-----
Y
----
Y
----
A
--
Y
-
V
-
T
--
E
-
R
Q
K
V
----
H
C
----
L
N
T
L
F
S
-
R
-
L
-----
Q
I
N
Q
-
S
I
I
F
C
N
S
-
S
Q
R
V
E
L
L
----
A
K
K
I
S
---
Q
L
---
G
------
Y
S
C
---
F
Y
I
---
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
----
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
-
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.50
37%
-92
- C6 -
4CT4
3
DDX6_HUMAN
B:
[12-367]
-----
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
-
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
----------
D
L
K
------------------
K
-----
D
--------
N
I
-
Q
----
A
-
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
-----
K
H---
M
-
G
----
G
---
A
K
-
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
-
L
-
D
D
T
--
V
--
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
--
K
-
G
-
V
A
K
V
D
--
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
L
T
--
L
----
P
----
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
----
Q
K
F
M
N
S
H
-------------
L
----------------------
Q
K
P
Y
E
I
-----
N
------
L
-----
M
-----
E
E
------
L
----
T
LKG
V
---
T
Q
-----
Y
----
Y
----
A
--
Y
-
V
-
T
--
E
-
R
Q
K
V
----
H
C
----
L
N
T
L
F
S
-
R
-
L
-----
Q
I
N
Q
-
S
I
I
F
C
N
S
-
S
Q
R
V
E
L
L
----
A
K
K
I
S
---
Q
L
---
G
------
Y
S
C
---
F
Y
I
---
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
-
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.02
38%
-81
- C6 -
2HYI
3
IF4A3_HUMAN
C:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
RD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.99
38%
-82
- C6 -
3EX7
4
IF4A3_HUMAN
C:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
RD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.90
38%
-81
- C6 -
3EX7
4
IF4A3_HUMAN
H:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
LVKRD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
REA
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
82.89
38%
-79
- C6 -
2XB2
4
IF4A3_HUMAN
A:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
RD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.69
38%
-76
- C6 -
2J0Q
3
IF4A3_HUMAN
A:
[39-401]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
RD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
82.66
38%
-77
- C6 -
2J0Q
3
IF4A3_HUMAN
B:
[39-401]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
LVKRD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
REA
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.60
38%
-82
- C6 -
2J0S
3
IF4A3_HUMAN
A:
[39-401]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
RD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
82.36
38%
-80
- C6 -
2HYI
3
IF4A3_HUMAN
I:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
LVKRD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
REA
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.33
38%
-87
- C6 -
2HXY
-
IF4A3_HUMAN
A:
[40-402]
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
-
Q
R
A
I
K
Q
I
I
K
--
G
--
R
-
D
--
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
---
C
L
----------
D
I
Q
------------------
V
-----
R
--------
E
T
-
Q
----
A
-
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
-----
D
----
Y
-
M
----
N
---
V
Q
-
C
H
A
C
I
G
G
T
N
V
--
G
E
D
I
R
K
-
L
-
D
Y
G
--
Q
--
H
V
V
A
G
T
P
G
R
V
F
D
M
I
-
R
--
R
-
R
-
S
L
R
T
R
--
A
-
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
--
K
-
G
F
K
E
Q
I
Y
D
V
-
Y
R
Y
--
L
----
P
----
P
-------
A
--
T
-------
Q
V
V
L
I
S
A
T
L
P
H
E
I
----
L
E
M
T
N
K
F
-------------
M
----------------------
T
D
P
I
R
I
L
V
K
R
D
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
F
----
V
----
A
--
V
-
E
-
R
--
E
-
E
W
K
F
----
D
T
----
L
C
D
L
Y
D
-
T
-
L
-----
T
I
T
Q
-
A
V
I
F
C
N
T
-
K
R
K
V
D
W
L
----
T
---
E
---
K
M
R
E
A
N
------
F
T
V
---
S
S
M
---
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
K
-
N
D
D
-
I
-
R
I
L
R
D
I
E
Q
Y
Y
S
T
Q
I
D
E
--------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.89
37%
-102
- C6 -
2VSO
1
IF4A_YEAST
B:
[24-385]
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
-
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
----------
D
T
S
------------------
V
-----
K
--------
A
P
-
Q
----
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-----
F
----
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
---------------
L
R
D
--
A
--
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
-
R
F
R
T
D
--
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
----
P
----
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
----
L
E
V
T
T
K
F
-------------
M
----------------------
R
N
P
V
R
I
LVKKD
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
Y
----
V
----
N
--
V
-
E
-
E
--
E
-
E
Y
K
Y
----
E
C
----
L
T
D
L
Y
D
-
S
-
I
-----
S
V
T
Q
-
A
V
I
F
C
N
T
-
R
R
K
V
E
E
L
----
T
---
T
---
K
L
RND
K
------
F
T
V
---
S
A
I
---
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
-
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
--------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
81.58
37%
-101
- C6 -
2VSO
1
IF4A_YEAST
A:
[24-385]
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
-
I
E
--
G
--
H
-
D
--
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
---
R
I
----------
D
T
S
------------------
V
-----
K
--------
A
P
-
Q
----
A
-
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
A
L
A
-----
F
----
H
-
M
----
D
---
I
K
-
V
H
A
C
I
G
---------------
L
R
D
--
A
--
Q
I
V
V
G
T
P
G
R
V
F
D
N
I
-
Q
--
R
-
R
-
R
F
R
T
D
--
K
-
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
--
S
-
G
F
K
E
Q
I
Y
Q
I
-
F
T
L
--
L
----
P
----
P
-------
T
--
T
-------
Q
V
V
L
L
S
A
T
M
P
N
D
V
----
L
E
V
T
T
K
F
-------------
M
----------------------
R
N
P
V
R
I
L
V
K
K
D
E
------
L
-----
T
-----
L
E
------
G
----
I
---
K
---
Q
F
-----
Y
----
V
----
N
--
V
-
E
-
E
--
E
-
E
Y
K
Y
----
E
C
----
L
T
D
L
Y
D
-
S
-
I
-----
S
V
T
Q
-
A
V
I
F
C
N
T
-
R
R
K
V
E
E
L
----
T
---
T
---
K
L
R
N
D
K
------
F
T
V
---
S
A
I
---
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
T
-
N
E
D
-
V
-
G
A
M
R
E
L
E
K
F
Y
S
T
Q
I
E
E
--------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
81.30
37%
-91
- C6 -
4CT5
1
DDX6_HUMAN
B:
[12-367]
-----
L
K
R
E
L
L
M
G
I
F
E
M
G
W
E
K
P
S
P
I
Q
-
E
E
S
I
P
I
A
L
S
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
S
G
A
Y
L
I
P
L
L
E
---
R
L
----------
D
L
K
------------------
K
-----
D
--------
N
I
-
Q
----
A
-
M
V
I
V
P
T
R
E
L
A
L
Q
V
S
Q
I
C
I
Q
V
S
-----
K
H---
M
-
G
----
G
---
A
K
-
V
M
A
T
T
G
G
T
N
L
--
R
D
D
I
M
R
-
L
-
D
D
T
--
V
--
H
V
V
I
A
T
P
G
R
I
L
D
L
I
-
K
--
K
-
G
-
V
A
K
V
D
--
H
-
V
Q
M
I
V
L
D
E
A
D
K
L
L
-
S
--
Q
-
D
F
V
Q
I
M
E
D
I
-
I
L
T
--
L
----
P
----
K
-------
N
--
R
-------
Q
I
L
L
Y
S
A
T
F
P
L
S
V
----
Q
K
F
M
N
S
H
-------------
L
----------------------
Q
K
P
Y
E
I
-----
N
------
L
-----
M
-----
E
E
------
L
----
T
LKG
V
---
T
Q
-----
Y
----
Y
----
A
--
Y
-
V
-
T
--
E
-
R
Q
K
V
----
H
C
----
L
N
T
L
F
S
-
R
-
L
-----
Q
I
N
Q
-
S
I
I
F
C
N
S
-
S
Q
R
V
E
L
L
----
A
KKI
S
---
Q
L
---
G
------
Y
S
C
---
F
Y
I
---
H
A
K
M
R
Q
E
H
R
N
R
V
F
H
D
F
R
N
G
L
C
R
N
L
V
C
T
D
L
F
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
L
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
T
-
Y
D
D
-
R
-
F
N
L
K
S
I
E
E
Q
L
G
T
E
I
K
---------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
81.04
33%
-88
- C6 -
3FHT
4
DD19B_HUMAN
A:
[30-398]
---
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
-
E
N
A
L
P
L
M
L
A
EP
P
--
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
----------
E
P
A
------------------
N
-----
K
--------
Y
P
-
Q
----
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-----
K
----
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
--------
K
L
E
-
R
-
G
Q
K
IS
E
--
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
-
F
I
D
P
K
--
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
----
P
----
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
----
W
K
F
A
Q
K
V
-------------
V
----------------------
P
D
P
N
V
I
-----
K
------
L
-----
K
-----
R
E
------
E
ETLD
T
---
I
---
K
Q
-----
Y
----
Y
----
V
--
L
-
C
-
S
--
S
R
D
E
K
F
----
Q
A
----
L
C
N
L
Y
G
-
A
-
I
-----
T
I
A
Q
-
A
M
I
F
C
H
T
-
R
K
T
A
S
W
L
----
A
---
A
---
E
L
---
S
------
K
E
G
---
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
-
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
--------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
80.07
33%
-90
- C6 -
3G0H
4
DD19B_HUMAN
A:
[46-414]
---
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
-
E
N
A
L
P
L
M
L
A
EP
P
--
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
----------
E
P
A
------------------
N
-----
K
--------
Y
P
-
Q
----
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-----
K
----
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
--------
K
L
E
-
R
-
G
Q
K
IS
E
--
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
-
F
I
D
P
K
--
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
----
P
----
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
----
W
K
F
A
Q
K
V
-------------
V
----------------------
P
D
P
N
V
I
-----
K
------
L
-----
K
-----
R
E
------
E
ETLD
T
---
I
---
K
Q
-----
Y
----
Y
----
V
--
L
-
C
-
S
--
S
R
D
E
K
F
----
Q
A
----
L
C
N
L
Y
G
-
A
-
I
-----
T
I
A
Q
-
A
M
I
F
C
H
T
-
R
K
T
A
S
W
L
----
A
---
A
---
E
L
---
S
------
K
E
G
---
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
-
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
--------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.78
37%
-83
- C6 -
4D26
4
?
A:
[69-421]
-----------------
G
Y
R
K
P
T
P
I
Q
-
K
N
A
I
P
I
I
M
S
--
G
--
R
-
D
--
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
----------
L
Q
D
P
K
D
L
I
S
------------
E
-----
N
G
C
A
-----
Q
P
-
Q
----
V
-
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-----
Y
----
G
-
S
----
V
---
L
K
-
V
A
V
A
Y
G
G
T
A
V
--
R
H
Q
G
D
N
-
I
-
A
R
G
--
C
--
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
--
R
-
N
-
R
V
S
F
G
--
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
F
M
P
S
I
E
K
M
-
M
L
H
--
P
----
T
MVET
T
-------
K
--
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
----
Q
H
L
A
G
R
F
-------------
L
----------------------
N
N
Y
L
F
V
-----
A
------
V
G
IVGG
A
-----
S
T
------
D
----
V
---
E
---
Q
I
-----
F
---------
I
--
E
-
V
-
T
--
K
-
Y
E
K
R
----
N
S
----
L
K
Q
L
I
E
-
E
-
N
-----
D
G
K
R
-
I
L
V
F
V
E
T
-
K
R
N
A
D
F
I
----
A
---
A
---
M
L
---
S
E
Q
Q---
L
L
T
---
S
S
I
---
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
-
D
L
A
L
V
A
D
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
79.70
37%
-83
- C6 -
4D25
4
?
A:
[69-421]
-----------------
G
Y
R
K
P
T
P
I
Q
-
K
N
A
I
P
I
I
M
S
--
G
--
R
-
D
--
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
---
M
L
----------
L
Q
D
PKD
L
I
S
------------
E
-----
N
G
C
A
-----
Q
P
-
Q
----
V
-
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
-----
Y
----
G
-
S
----
V
---
L
K
-
V
A
V
A
Y
G
G
T
A
V
--
R
H
Q
G
D
N
-
I
-
A
R
G
--
C
--
H
I
L
V
A
T
P
G
R
L
H
D
F
V
-
E
--
R
-
N
-
R
V
S
F
G
--
S
-
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
--
M
-
G
F
M
P
S
I
E
K
M
-
M
L
H
--
P
----
T
MVET
T
-------
K
--
R
-------
Q
T
L
M
F
S
A
T
F
P
E
D
I
----
Q
H
L
A
G
R
F
-------------
L
----------------------
N
N
Y
L
F
V
-----
A
------
V
GIVGG
A
-----
S
T
------
D
----
V
---
E
---
Q
I
-----
F
---------
I
--
E
-
V
-
T
--
K
-
Y
E
K
R
----
N
S
----
L
K
Q
L
I
E
-
E
-
N
-----
D
G
K
R
-
I
L
V
F
V
E
T
-
K
R
N
A
D
F
I
----
A
---
A
---
M
L
---
S
E
Q
Q---
L
L
T
---
S
S
I
---
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
D
-
S
D
Q
-
D
L
A
L
V
A
D
L
S
K
I
L
--------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
78.49
33%
-90
- C6 -
3FHT
6
DD19B_HUMAN
B:
[30-398]
---
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
-
E
N
A
L
P
L
M
L
A
EP
P
--
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
----------
E
P
A
------------------
N
-----
K
--------
Y
P
-
Q
----
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-----
K
----
F
Y
P
----
E
---
L
K
L
A
Y
A
V
R
G
N
----------------
K
IS
E
--
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
L
K
-
F
I
D
P
K
--
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
--
Q
-
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
----
P
----
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
----
W
K
F
A
Q
K
V
-------------
V
----------------------
P
D
P
N
V
I
-----
K
------
L
-----
K
-----
R
E
------
E
ETLD
T
---
I
---
K
Q
-----
Y
----
Y
----
V
--
L
-
C
-
S
--
S
R
D
E
K
F
----
Q
A
----
L
C
N
L
Y
G
-
A
-
I
-----
T
I
A
Q
-
A
M
I
F
C
H
T
-
R
K
T
A
S
W
L
----
A
---
A
---
E
L
---
S
------
K
E
G
---
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
-
S
K
H
-
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
--------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
78.11
32%
-104
- C6 -
1XTI
4
DX39B_HUMAN
A:
[12-374]
--
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
-
H
E
C
I
P
Q
A
I
L
--
G
--
M
-
D
--
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
----------
E
P
V
------------------
T
-----
G
--------
Q
V
-
S
----
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-----
K
----
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
-
E
-
V
-
L
K
K
--
N
CP
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
-
S
L
N
L
K
--
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
--
L
-
D
M
R
R
D
V
Q
E
I
-
F
R
M
--
T
----
P
----
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
----
R
P
V
C
R
K
F
-------------
M
----------------------
Q
D
P
M
E
I
-----
F
------
V
-----
D
-----
D
E
------
T
----
K
---
L
---
T
L
HG
L
Q
Q
Y
----
Y
----
V
--
K
-
L
-
K
--
D
-
N
E
K
N
----
R
K
----
L
F
D
L
L
D
-
V
-
L
-----
E
F
N
Q
-
V
V
I
F
V
K
S
-
V
Q
R
C
I
A
L
----
A
---
Q
---
L
L
V
E
Q
N
------
F
P
A
---
I
A
I
---
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
S
D
E
N
D
-
A
-
K
I
L
N
D
V
Q
D
R
F
E
V
N
I
----------------------------------------------------------------------------------------------------------------------
107
HHSearch
77.97
33%
-85
- C6 -
3FHT
4
DD19B_HUMAN
A:
[27-399]
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
-
E
N
A
L
P
L
M
L
A
--
E
P
P
Q
-
N
--
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
---
Q
V
----------
E
P
A
------------------
N
-----
K
--------
Y
P
-
Q
----
C
-
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
-----
K
----
F
-
Y
----
P
E--
L
K
-
L
A
Y
A
V
R
G
N
K
-----
L
E
R
G
-
Q
-
K
I
S
--
E
--
Q
I
V
I
G
T
P
G
T
V
L
D
W
C
-
S
--
K
-
L
K
F
I
D
P
K
--
K
-
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
--
T
Q
G
H
Q
D
Q
S
I
R
I
-
Q
R
M
--
L
----
P
----
R
-------
N
--
C
-------
Q
M
L
L
F
S
A
T
F
E
D
S
V
----
W
K
F
A
Q
K
V
-------------
V
----------------------
P
D
P
N
V
I
-----
K
------
L
-----
K
-----
R
E
EE----
T
----
L
---
D
---
T
I
-----
K
----
Q
----
Y
Y
V
L
-
C
S
S
--
R
-
D
E
K
F
----
Q
A
----
L
C
N
L
Y
G
-
A
-
I
-----
T
I
A
Q
-
A
M
I
F
C
H
T
-
R
K
T
A
S
W
L
----
A
---
A
---
E
L
---
S
K
E
G---
H
Q
V
---
A
L
L
---
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
------
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
D
-
S
K
H
S
M
-
N
I
L
N
R
I
Q
E
H
F
N
K
K
I
E
R
L
-------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
77.70
36%
-84
- C6 -
4BRW
2
DHH1_YEAST
A:
[5-361]
--
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
-
E
E
A
I
P
V
A
I
T
--
G
--
R
-
D
--
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
---
K
V
----------
K
P
K
------------------
L
-----
N
--------
K
I
-
Q
----
A
-
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
-----
K
----
H
-
C
----
G
---
I
S
-
C
M
V
T
T
G
G
T
N
L
--
R
D
D
I
L
R
-
L
-
N
E
T
--
V
--
H
I
L
V
G
T
P
G
R
V
L
D
L
A
-
S
--
R
-
K
-
V
A
D
L
S
--
D
-
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
--
R
-
D
F
K
T
I
I
E
Q
I
-
L
S
F
--
L
----
P
----
P
-------
T
--
H
-------
Q
S
L
L
F
S
A
T
F
P
L
T
V
----
D
E
F
M
D
K
H
-------------
L
----------------------
H
K
P
Y
E
I
-----
N
------
L
-----
M
-----
E
E
------
L
----
T
---
L
KG
I
T
Q
-----
Y
----
Y
----
A
--
F
-
V
-
E
--
E
-
R
Q
K
L
----
H
C
----
L
N
T
L
F
S
-
K
-
L
-----
Q
I
N
Q
-
A
I
I
F
C
N
S
-
T
N
R
V
E
L
L
A
K
K
I
T
---
D
----
L
---
G
------
Y
S
C
---
Y
Y
S
---
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
N
-
W
N
D
-
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
----------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
75.87
40%
-92
- C6 -
4KBF
3
?
A:
[3-324]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
ERG--
R
--------
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-----
N
------
V
-----
I
-------------
K
----
D
---
E
---
P
V
-----
T
----
Y
E
E
E
A
V
--
P
-
A
-
P
--
V
-
R
G
R
L
----
E
V
----
L
S
D
L
L
Y
-
V
-
A
-----
S
P
D
R
-
A
M
V
F
T
R
T
-
K
A
E
T
E
E
I
----
A
---
Q
G
L
L
R
L
---
G
------
H
P
A
---
Q
A
L
---
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
75.73
34%
-70
- C6 -
3PEY
11
DBP5_YEAST
A:
[7-379]
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
-
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
----------
N
P
E
------------------
D
-----
A
--------
S
P
-
Q
----
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-----
K
----
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
P
D
S
-
F
--
E
K
N
K
Q
I
-
N
-
A
Q
-------
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
-
L
M
Q
L
Q
--
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
--
Q
-
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
----
P
----
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
----
R
Q
Y
A
K
K
I
-------------
V
----------------------
P
N
A
N
T
L
-----
E
------
L
-----
Q
-----
T
N
------
E
----
V
---
N
---
V
D
-----
A
----
I
----
K
--
Q
-
L
-
Y
--
M
-
D
C
K
N
----
E
A
----
D
K
F
D
V
L
-
T
-
E
L
Y
G
L
M
T
I
G
S
-
S
I
I
F
V
A
T
-
K
K
T
A
N
V
L
----
Y
---
G
---
K
L
---
K
------
S
E
G
HE
V
S
I
L
---
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-
D
I
E
M
T
R
V
-
P
T
--------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
75.51
34%
-71
- C6 -
3PEW
10
DBP5_YEAST
A:
[7-379]
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
-
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
----------
N
P
E
------------------
D
-----
A
--------
S
P
-
Q
----
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-----
K
----
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
P
D
S
-
F
--
E
K
N
K
Q
I
-
N
-
A
Q
-------
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
-
L
M
Q
L
Q
--
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
D
Q
--
Q
-
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
----
P
----
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
----
R
Q
Y
A
K
K
I
-------------
V
----------------------
P
N
A
N
T
L
-----
E
------
L
-----
Q
-----
T
N
------
E
----
V
---
N
---
V
D
-----
A
----
I
----
K
--
Q
-
L
-
Y
--
M
-
D
C
K
N
----
E
A
----
D
K
F
D
V
L
-
T
-
E
L
YGVM
T
I
G
S
-
S
I
I
F
V
A
T
-
K
K
T
A
N
V
L
----
Y
---
G
---
K
L
---
K
------
S
E
G
H
E
V
S
I
L
---
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
-
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-
D
I
E
M
T
R
V
-
P
T
--------------------------------------------------------------------------------------------------------------
110
HHSearch
74.43
34%
-84
- C6 -
3PEY
11
DBP5_YEAST
A:
[7-363]
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
-
E
R
A
L
P
L
L
L
H
--
N
P
P
R
-
N
--
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
---
R
V
----------
N
P
E
------------------
D
-----
A
--------
S
P
-
Q
----
A
-
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
-----
K
----
F
-
T
----
K
---
I
T
-
S
Q
L
I
V
P
D
S
F
E
------
K
N
-
K
-
Q
I
N
--
A
--
Q
V
I
V
G
T
P
G
T
V
L
D
L
M
-
R
--
R
-
K
-
L
M
Q
L
Q
--
K
-
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
--
Q
Q
G
L
G
D
Q
C
I
R
V
-
K
R
F
--
L
----
P
----
K
-------
D
--
T
-------
Q
L
V
L
F
S
A
T
F
A
D
A
V
----
R
Q
Y
A
K
K
I
-------------
V
----------------------
P
N
A
N
T
L
-----
E
------
L
-----
Q
-----
T
N
EV----
N
----
V
---
D
---
A
I
-----
K
----
Q
----
L
Y
M
D
-
C
K
N
--
E
-
A
D
K
F
----
D
V
----
L
T
E
L
Y
G
-
L
-
M
-----
T
I
G
S
-
S
I
I
F
V
A
T
-
K
K
T
A
N
V
L
----
Y
---
G
---
K
L
---
K
S
E
G---
H
E
V
---
S
I
L
---
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
-
D
K
N
-
S
-
F
N
I
L
S
-------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
73.55
32%
-74
- C6 -
3SQW
3
MS116_YEAST
A:
[25-408]
--
E
G
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
SE
D
--
H
-
D
--
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
KFDS--------------
Q
-----
Y
--------
M
V
-
K
----
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
----
M
-
N
YGLK
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
--
R
A
A
M
N
K
M
N
-
K
L
R
--
P
--
N
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
S
N
K
F
F
R
--
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
K
NSKSAD
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
----------------------
N
K
K
E
C
L
-----
F
------
L
-----
D
-----
T
V
DKNEPE
A
----
H
---
E
---
R
I
-----
D
----
Q
----
S
V
V
I
-
S
E
K
--
F
-
A
N
S
I
----
F
A
A
V
E
H
I
K
K
Q
I
K
E
R
-
D
-----
S
N
Y
K
-
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
----
C
---
S
---
I
L
---
K
N
E
FKKD
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
----------------------------------------------------------------------------------------------------------------------------
105
HHSearch
73.06
32%
-76
- C6 -
3I5X
3
MS116_YEAST
A:
[78-459]
----
V
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
SE
D
--
H
-
D
--
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
KFDS--------------
Q
-----
Y
--------
M
V
-
K
----
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
----
M
-
N
Y---
G
LKK
Y
A
-
C
V
S
L
V
G
G
T
D
F
--
R
A
A
M
N
K
-
M
N
K
L
R
--
P
--
N
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
S
N
K
F
F
R
--
F
-
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
K
NSKSAD
N
--
I
-------
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
----------------------
N
K
K
E
C
L
-----
F
------
L
-----
D
-----
T
V
DKNEPE
A
----
H
---
E
---
R
I
-----
D
----
Q
----
S
--
V
V
I
-
S
EK
F
-
A
N
S
I
F
A
A
V
E
H
----
I
K
K
Q
I
K
E
R
-
D
-----
S
N
Y
K
-
A
I
I
F
A
P
T
-
V
K
F
T
S
F
L
----
C
---
S
---
I
L
---
K
N
E
FKKD
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
----------------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
72.77
31%
-74
- C6 -
3I5Y
3
MS116_YEAST
A:
[79-470]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
NKK
E
C
L
F
L
D
TVDKNEPEAHERI
D
Q
S
V
V
I
------------------------
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
72.64
31%
-73
- C6 -
3I61
4
MS116_YEAST
A:
[79-470]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
NKK
E
C
L
F
L
D
TVDKNEPEAHERI
D
Q
S
V
V
I
------------------------
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
72.61
31%
-78
- C6 -
3SQW
3
MS116_YEAST
A:
[28-419]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
MNKKECLFLDTVD
K
----------------------
N
E
P
E
A
H
-----
E
RID
Q
S
V
V
-----
I
-----
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
72.15
31%
-74
- C6 -
3I5X
3
MS116_YEAST
A:
[79-470]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
NKK
E
C
L
F
L
D
TVDKNEPEAHERI
D
Q
S
V
V
I
------------------------
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
71.83
31%
-74
- C6 -
3SQX
3
MS116_YEAST
A:
[28-419]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
NKK
E
C
L
F
L
D
TVDKNEPEAHERI
D
Q
S
V
V
I
------------------------
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
71.71
31%
-73
- C6 -
3I62
4
MS116_YEAST
A:
[79-470]
-----
L
D
K
E
I
H
K
A
I
T
R
M
E
F
P
G
L
T
P
V
Q
-
Q
K
T
I
K
P
I
L
S
--
S
--
E
-
D
H
D
V
I
A
R
A
K
T
G
T
G
K
T
F
A
F
L
I
P
I
F
Q
---
H
L
----------
I
N
T
------------------
K
-----
F
--------
D
S
-
Q
YMVK
A
-
V
I
V
A
P
T
R
D
L
A
L
Q
I
E
A
E
V
K
K
I
H
-----
D
M
NYG
L
-
K
----
K
---
Y
A
-
C
V
S
L
V
G
G
T
D
F
R
A
A
M
N
K
M
N
-
K
-
L
R
P
--
N
---
I
V
I
A
T
P
G
R
L
I
D
V
L
-
E
--
K
-
Y
-
S
N
K
F
F
--
R
F
V
D
Y
K
V
L
D
E
A
D
R
L
L
-
E
--
I
-
G
F
R
D
D
L
E
T
I
-
S
G
I
--
L
----
N
----
E
-------
K
--
N
SKSADN
I
K
T
L
L
F
S
A
T
L
D
D
K
V
----
Q
K
L
A
N
N
I
-------------
M
NKK
E
C
L
F
L
D
TVDKNEPEAHERI
D
Q
S
V
V
I
------------------------
S
E
------
K
F
---
A
---
N
---
S
I
-----
F
A
A
V
E
H
----
I
--
K
-
K
-
Q
--
I
-
K
E
R
D
----
S
N
----
Y
K
A
I
I
F
-
A
-
P
-----
T
V
K
F
-
T
S
F
L
C
S
I
L
K
N
E
F
K
K
------------------
D
------
L
P
I
---
L
E
F
---
H
G
K
I
T
Q
N
K
R
T
S
L
V
K
R
F
K
K
D
E
S
G
I
L
V
C
T
D
V
G
A
R
G
M
D
F
P
N
V
H
E
V
L
Q
I
G
V
P
S
------
E
L
------
A
N
Y
I
H
R
I
G
R
T
A
R
S
G
K
E
G
S
S
V
L
F
I
C
-
K
D
E
-
L
-
P
F
V
R
E
L
E
D
A
K
N
I
V
I
A
K
Q
E
K
-----------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
63.52
44%
-108
- C6 -
2GXS
4
?
B:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
63.19
44%
-105
- C6 -
2GXQ
2
?
A:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
62.96
44%
-106
- C6 -
2GXS
3
?
A:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
62.95
44%
-96
- C6 -
3NBF
2
?
A:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
62.48
44%
-111
- C6 -
3MWL
2
?
B:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
62.23
44%
-109
- C6 -
3NBF
2
?
D:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
61.92
44%
-100
- C6 -
3NBF
2
?
B:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
61.88
36%
-95
- C6 -
4PX9
1
DDX3X_HUMAN
A:
[67-283]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
Y
S
D
GPGEALR
A
M
K
------------------
E
-----
N
GRYG
R
R
K
Q
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
61.75
36%
-95
- C6 -
4PX9
1
DDX3X_HUMAN
C:
[67-283]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
YSDGPGEALR
A
M
K
------------------
E
-----
N
GRYGRRKQ
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
61.66
44%
-105
- C6 -
3MWK
2
?
B:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RGR-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
61.56
44%
-105
- C6 -
3NBF
4
?
C:
[3-203]
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
-
A
A
A
L
P
L
A
L
E
--
G
--
K
-
D
--
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
---
R
L
----------
A
P
S
------------------
Q
-----
E
RG
R
-----
K
P
-
R
----
A
-
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
------------
P
----
H
---
L
K
-
V
V
A
V
Y
G
G
T
G
Y
--
G
K
Q
K
E
A
-
L
-
L
R
G
--
A
--
D
A
V
V
A
T
P
G
R
A
L
D
Y
L
-
R
--
Q
-
G
-
V
L
D
L
S
--
R
-
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
--
M
-
G
F
E
E
E
V
E
A
L
-
L
S
A
--
T
----
P
----
P
-------
S
--
R
-------
Q
T
L
L
F
S
A
T
L
P
S
W
A
----
K
R
L
A
E
R
Y
-------------
M
----------------------
K
N
P
V
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
61.43
36%
-94
- C6 -
4PX9
1
DDX3X_HUMAN
B:
[67-283]
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
-
K
H
A
I
P
I
I
K
E
--
K
--
R
-
D
--
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
---
Q
I
Y
S
D
GPGEALR
A
M
K
------------------
E
-----
N
GRYG
R
R
K
Q
Y
P
-
I
----
S
-
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
-----
Y
----
R
-
S
----
R
---
V
R
-
P
C
V
V
Y
G
G
A
D
I
--
G
Q
Q
I
R
D
-
L
-
E
R
G
--
C
--
H
L
L
V
A
T
P
G
R
L
V
D
M
M
-
E
--
R
-
G
-
K
I
G
L
D
--
F
-
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
R
I
-
V
E
Q
DT
M
----
P
----
P
-------
K
GV
R
-------
H
T
M
M
F
S
A
T
F
P
K
E
I
----
Q
M
L
A
R
D
F
-------------
L
----------------------
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
59.64
34%
-106
- C6 -
1T6N
1
DX39B_HUMAN
A:
[18-218]
--
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
-
H
E
C
I
P
Q
A
I
L
--
G
--
M
-
D
--
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
----------
E
P
V
------------------
T
-----
G
--------
Q
V
-
S
----
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-----
K
----
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
-
E
-
V
-
L
K
K
--
N
CP
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
-
S
L
N
L
K
--
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
--
L
-
D
M
R
R
D
V
Q
E
I
-
F
R
M
--
T
----
P
----
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
----
R
P
V
C
R
K
F
-------------
M
----------------------
Q
D
P
M
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
58.48
38%
-96
- C6 -
3BER
4
DDX47_HUMAN
A:
[47-249]
--
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
-
I
E
A
I
P
L
A
L
Q
--
G
--
R
-
D
--
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
N
---
A
L
----------
L
E
T
------------------
P
-----
Q
--------
R
L
-
F
----
A
-
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
-----
S
----
S
-
I
----
G
---
V
Q
-
S
A
V
I
V
G
G
I
D
S
--
M
S
Q
S
L
A
-
L
-
A
K
K
--
P
--
H
I
I
I
A
T
P
G
R
L
I
D
H
L
-
E
NT
K
-
G
--
F
N
L
R
--
A
-
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
--
M
-
D
F
E
T
E
V
D
K
I
-
L
K
V
--
I
----
P
----
R
-------
D
--
R
-------
K
T
F
L
F
S
A
T
M
T
K
K
V
----
Q
K
L
Q
R
A
A
-------------
L
----------------------
K
N
P
V
K
C
-----
A
------
V
-----
S
-----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
58.19
34%
-105
- C6 -
1T6N
1
DX39B_HUMAN
B:
[18-218]
--
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
-
H
E
C
I
P
Q
A
I
L
--
G
--
M
-
D
--
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
---
Q
L
----------
E
P
V
------------------
T
-----
G
--------
Q
V
-
S
----
V
-
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
-----
K
----
Y
M
P
----
N
---
V
K
-
V
A
V
F
F
G
G
L
S
I
--
K
K
D
E
-
E
-
V
-
L
K
K
--
N
CP
H
I
V
V
G
T
P
G
R
I
L
A
L
A
-
R
--
N
-
K
-
S
L
N
L
K
--
H
-
I
K
H
F
I
L
D
E
C
D
K
M
L
E
Q
--
L
-
D
M
R
R
D
V
Q
E
I
-
F
R
M
--
T
----
P
----
H
-------
E
--
K
-------
Q
V
M
M
F
S
A
T
L
S
K
E
I
----
R
P
V
C
R
K
F
-------------
M
----------------------
Q
D
P
M
E
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
57.71
37%
-97
- C6 -
2PL3
5
DDX10_HUMAN
A:
[27-227]
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
-
K
Q
T
I
G
L
A
L
Q
--
G
--
K
-
D
--
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
Y
R
L
----------
Q
W
T
------------------
S
-----
T
--------
D
G
-
L
----
G
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
-----
K
----
N
-
H
----
D
---
F
S
-
A
G
L
I
I
G
G
--
L
---
K
H
E
A
E
-
R
-
I
N
N
--
I
--
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
--
T
-
V
-
S
F
H
A
T
--
D
-
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
--
M
-
G
F
A
D
T
M
N
A
V
-
I
E
N
--
L
----
P
----
K
-------
K
--
R
-------
Q
T
L
L
F
S
A
T
Q
T
K
S
V
----
K
D
L
A
R
L
S
-------------
L
----------------------
K
N
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
52.13
39%
-88
- C6 -
3FE2
4
DDX5_HUMAN
B:
[49-232]
------------------
F
T
E
P
T
A
I
Q
-
A
Q
G
W
P
V
A
L
S
--
G
--
L
-
D
--
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
----------
N
H
Q
------------------
P
FLERG
D
--------
G
P
-
I
----
C
-
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-----
R
----
A
-
C
----
R
---
L
K
-
S
T
C
I
Y
G
G
A
P
K
--
G
P
Q
I
R
D
-
L
-
E
R
G
--
V
--
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
--
C
-
G
-
K
T
N
L
R
--
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
K
I
-
V
D
Q
--
I
----
R
----
P
-------
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
RQLA
E
D
F
L
K
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
51.95
39%
-86
- C6 -
3FE2
2
DDX5_HUMAN
A:
[49-232]
------------------
F
T
E
P
T
A
I
Q
-
A
Q
G
W
P
V
A
L
S
--
G
--
L
-
D
--
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
---
H
I
----------
N
H
Q
------------------
P
FLERG
D
--------
G
P
-
I
----
C
-
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
V
A
A
E
Y
C
-----
R
----
A
-
C
----
R
---
L
K
-
S
T
C
I
Y
G
G
A
P
K
--
G
P
Q
I
R
D
-
L
-
E
R
G
--
V
--
E
I
C
I
A
T
P
G
R
L
I
D
F
L
-
E
--
C
-
G
-
K
T
N
L
R
--
R
-
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
--
M
-
G
F
E
P
Q
I
R
K
I
-
V
D
Q
--
I
----
R
----
P
-------
D
--
R
-------
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
PsiBlast_CBE
51.66
33%
-83
- C6 -
3DKP
4
DDX52_HUMAN
A:
[35-242]
----
K
I
N
S
R
L
L
Q
N
I
L
D
A
G
F
Q
M
P
T
P
I
Q
-
M
Q
A
I
P
V
M
L
H
--
G
--
R
-
E
--
L
L
A
S
A
P
T
G
S
G
K
T
L
A
F
S
I
P
I
L
M
---
Q
L
----------
K
Q
P
------------------
A
-----
N
--------
K
G
F
R
----
A
-
L
I
I
S
P
T
R
E
L
A
S
Q
I
H
R
E
L
I
K
I
S
EGTG
F
R
----
I
-
H
----
M
---
I
H
-
K
A
A
V
A
A
K
K
-
F
--
G
P
K
S
-----
S
K
K
--
F
--
D
I
L
V
T
T
P
N
R
L
I
Y
L
L
-
K
--
Q
-
D
-
P
P
G
I
D
LA
S
-
V
E
W
L
V
V
D
E
S
D
K
L
F
-
E
D
G--
G
F
R
D
Q
L
A
S
I
F
L
A
C
--
T
----
S
----
H
-------
K
--
V
-------
R
R
A
M
F
S
A
T
F
A
Y
D
V
----
E
Q
W
C
K
L
N
-------------
L
----------------------
D
N
V
I
S
V
-----
S
------
I
-----
G
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------