@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1447: (2016-03-24 )
MKKIIEVNNVSYHYDKEHALENIHFQVAKGSFTGLIGPNGSGKSTMLKLILGVLKKQQGSISLFGEKQADFKDWVKIGFVSQKSNAFNSAFPATVKEVVASGLTKKKGLFKTLNNKDKEDIDYALKRVEMTDYLHRNIGELSGGQQQRVFIARALVSRPELLILDEPTVGVDVENVKAFYELLAELNRTEEMTLLLVTHDLMAVNTYVNHVISINKRIIFDGSAHEYQHYLADRELEILAEQRRREDACLDCDASPV
Atome Classification :
(25 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10--...--.----.----.--.-----.20.........30........40........50........60....----.-----...70----.----------------..-------..-----.----.----..80......-------..90.......----------.100........110........120.-.....-----.130..-.---.-------...140--.........150.......160.......170.......180.......190.......200..--.....210...-.-.-...220.......230.......240.......250.....--------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
K
K
I
I
E
VNN
V
S
--
Y
HY--D----K----E--H-----AL-EN
I
H
F
Q
VAKG
S
F
T
G
L
IGPNGS
G
K
S
T
M
L
K
L
I
L
G
V
L
K
KQQG
S
I
S
L
FG----E-----KQA
D
-----
F
----------------
K
D
-------
W
V
-----
K
----I----
G
F
V
SQKSNAF-------NSA
F
P
A
T
V
K
E
V
----------
V
A
-SGLTKK
K
G
L
F
-
K
TLNNK
D
K
E
D
I
D
Y
-
A
L
K
R
V
-----
E
M
T
D
Y
L
-
H
---
R
-------
N
I
G
E----LSGGQ
Q
Q
R
V
F
I
A
R
A
L
VSRP
E
L
L
I
L
DEPTVGV
D
V
E
N
V
K
A
F
Y
E
L
L
A
E
LNRT
E
E
M
T
L
L
L
V
T
H
D
L
M
A
V
--
N
T
Y
V
N
H
V
-
I
SI-N-
K
-
R
I
I
FDG
S
A
H
E
Y
Q
H
Y
L
A
D
R
E
L
E
I
L
A
E
Q
R
RREDACLDCDASPV--------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.61
34%
-120
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[7-230]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
K
V
E
E
L
N
--
Y
N
Y
S-
D
----
G
----
T
--
H
-----
A
L
-
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
-
L
F
D
----
N
-----
K
P
I
D
-----
Y
S
R
--------------
K
G
-------
I
M
-----
K
L
R
E
S
I
----
G
I
V
F
Q
D
P
D
---------
N
Q
L
F
S
A
S
V
Y
Q
D
----------
V
S
-
F
G
A
V
N
----
M
-
K
L
P
E
D
E
I
R
K
R
V
D
N
-
A
L
K
R
T
-----
G
I
E
H
L
K
-
D
---
K
-------
P
T
H
C
----
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
--
P
L
Y
C
D
N
V
-
F
V
M
-
K
-
E
G
R
V
I
L
Q
G
N
P
K
E
---------------------------------------------------------------------------------------------------------------------------
69
HHSearch
86.77
32%
-106
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
L
K
V
E
E
L
N
--
Y
N
Y
--
S
----
D
G---
T
--
H
-----
A
L
-
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
L
F
D
N
----
K
-----
P
I
D
Y
S
R
K
G
I
M
----------------
K
L
-------
R
E
-----
S
----
I
----
G
I
V
F
Q
D
P
D
N
---------
Q
L
F
S
A
S
V
Y
Q
D
----------
V
S
-
F
G
A
V
N
M
K
-----
L
P
E
D
E
I
R
K
R
V
D
N
-
A
L
K
R
T
-----
G
I
E
H
L
K
-
D
---
K
-------
P
T
H
C
----
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
E
L
G
I
T
I
I
I
A
T
H
D
I
D
I
V
--
P
L
Y
C
D
N
V
-
F
V
M
K
E
-
G
-
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
---------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
85.03
32%
-112
- C1 -
4MKI
4
ECFA2_CALS4
B:
[7-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
--
F
I
Y
--
N
----
E
----
G
--
T
PYATV
A
L
-
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
IDIT
D
-----
K
K
V
S
-----
L
----------------
K
D
-------
I
R
-----
K
Q
---
V
----
G
L
V
F
Q
Y
P
E
Y
---------
Q
L
F
E
E
T
V
F
K
D
----------
I
A
-
F
G
P
S
N
----
L
-
G
L
S
E
E
E
V
K
E
R
V
Y
E
-
A
M
E
I
V
-----
G
I
S
K
E
L
A
D
---
K
-------
S
P
F
E
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
--
A
R
I
A
D
K
I
-
I
V
M
-
N
-
R
G
K
I
E
L
I
G
T
P
R
E
---------------------------------------------------------------------------------------------------------------------------
64
HHSearch
80.88
30%
-108
- C1 -
3D31
-
?
A:
[1-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
E
I
E
S
L
S
--
R
K
W
--
K
----
N
-------
F
-----
S
L
-
D
N
L
S
L
K
V
E
S
G
E
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
I
A
G
F
H
V
P
D
S
G
R
I
L
L
D
G
----
K
-----
D
V
T
D
-----
L
S---------------
P
E
-------
K
H
-----
D
----
I
----
A
F
V
Y
Q
N
Y
S
L
F
-------
P
H
---
M
N
V
K
K
N
----------
L
E
-
F
G
M
R
M
K
K
--------
I
K
D
P
K
R
V
L
D
-
T
A
R
D
L
-----
K
I
E
H
L
L
-
D
---
R
-------
N
P
L
T
----
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
T
Q
E
N
A
R
E
M
L
S
V
L
H
K
K
N
K
L
T
V
L
H
I
T
H
D
Q
T
E
A
--
R
I
M
A
D
R
I
-
A
V
V
M
D
-
G
-
K
L
I
Q
V
G
K
P
E
E
I
F
E
K
P
V
E
G
R
V
-----------------------------------------------------------------------------------------------------------------
63
HHSearch
79.30
31%
-110
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
--
K
V
F
--
H
----
Q
GTRT
I
--
Q
-----
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
----
Q
-----
E
L
T
T
-----
L
SESELT----------
K
A
-------
R
R
-----
Q
----
I
----
G
M
I
F
Q
H
F
N
L
L
-------
S
S
---
R
T
V
F
G
N
----------
V
A
-
L
P
L
E
L
D
N
T
---
P
--
K
D
E
V
K
R
R
V
T
E
-
L
L
S
L
V
-----
G
L
G
D
K
H
-
D
---
S
-------
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
--
K
R
I
C
D
C
V
-
A
V
I
S
N
-
G
-
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
----------------------------------------------------------------------------------------------------------------------
49
Fugue
78.26
26%
-95
- C1 -
1Z47
1
?
A:
[11-355]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
M
T
I
E
F
V
G
V
E
--
K
I
Y
--
P
----
G
----
G
--
A
R----
S
V
-
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
----
K
-----
R
V
T
D
-----
L
----------------
P
P
-------
Q
K
-----
R
N---
V
----
G
L
V
F
Q
N
Y
A
L
F
-------
Q
H
M
---
T
V
Y
D
N
----------
V
S
-
F
G
L
R
E
K
R
-----
V
P
K
D
E
M
D
A
R
V
R
E
-
L
L
R
F
M
-----
R
L
E
S
Y
A
-
N
---
R
-------
F
P
H
E
----
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
--
L
E
V
A
D
R
V
-
L
V
L
-
H
-
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
N
G
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
28
PsiBlast_CBE
77.77
32%
-114
- C1 -
4MKI
4
ECFA2_CALS4
A:
[7-234]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
V
E
N
V
S
--
F
I
Y
--
N
----
E
----
G
--
T
PYATV
A
L
-
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
IDIT
D
-----
K
K
V
S
-----
L
----------------
K
D
-------
I
R
-----
K
Q
---
V
----
G
L
V
F
Q
Y
P
E
Y
---------
Q
L
F
E
E
T
V
F
K
D
----------
I
A
-
F
G
P
S
N
----
L
-
G
L
S
E
E
E
V
K
E
R
V
Y
E
-
A
M
E
I
V
-----
G
I
S
K
E
L
A
D
---
K
-------
S
P
F
E
----
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
--
A
R
I
A
D
K
I
-
I
V
M
-
N
-
R
G
K
I
E
L
I
G
T
P
R
E
---------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
76.64
31%
-101
- C1 -
4U00
3
?
A:
[3-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
I
R
I
R
N
L
H
--
K
W
F
--
G
----
P
----
L
--
H
-----
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
-----
S
V
K
D
-----
D
----------------
R
A
-------
L
R
-----
E
----
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
-------
P
H
M
---
T
V
L
E
N
----------
V
T
-
L
A
P
M
R
V
R
R
W
P
-
R
E
K
A
E
K
K
A
L
E
L
----
L
E
R
V
-----
G
I
L
D
Q
A
-
R
---
K
-------
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
---------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
76.55
31%
-98
- C1 -
4U02
1
?
B:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
P
I
I
R
I
R
N
L
H
--
K
W
F
--
G
----
P
----
L
--
H
-----
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
-----
S
V
K
D
-----
D
----------------
R
A
-------
L
R
-----
E
----
I
RREV
G
M
V
F
Q
Q
F
N
L
F
-------
P
H
M
---
T
V
L
E
N
----------
V
T
-
L
A
P
M
R
V
R
R
W
P
-
R
E
K
A
E
K
K
A
L
E
L
----
L
E
R
V
-----
G
I
L
D
Q
A
-
R
---
K
-------
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
---------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.44
31%
-96
- C1 -
4U02
1
?
A:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
P
I
I
R
I
R
N
L
H
--
K
W
F
--
G
----
P
----
L
--
H
-----
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
-----
S
V
K
D
-----
D
----------------
R
A
-------
L
R
-----
E
----
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
-------
P
H
M
---
T
V
L
E
N
----------
V
T
-
L
A
P
M
R
V
R
R
W
P
-
R
E
K
A
E
K
K
A
L
E
L
----
L
E
R
V
-----
G
I
L
D
Q
A
-
R
---
K
-------
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
---------------------------------------------------------------------------------------------------------------------------
53
Fugue
75.94
30%
-94
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
--
F
T
Y
PG
R
----
E
----
V
--
P
-----
A
L
-
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
L
M
D
G
----
H
DL---
R
E
Y
T
-----
L
----------------
A
S
-------
L
R
-----
N
Q
---
V
----
A
L
V
S
Q
N
V
H
L
F
-------
N
D
----
T
V
A
N
N
----------
I
A
-
Y
A
----------
R
T
E
E
Y
S
R
E
Q
I
E
E
-
A
A
R
M
A
-----
Y
A
M
D
F
I
-
N
---
K
M
DNGLD
T
I
I
G
E
NGVL
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
K
N
R
--
T
S
L
V
I
A
H
R
L
S
T
I
--
E
Q
A
D
E
I
V
-
V
V
E
-
D
-
G
-
I
I
V
E
R
G
T
-----
H
S
E
L
L
A
Q
H
G
V
Y
A
Q
L
H
K
M
Q
F
G
-----------------------------------------------------------------------------------------------------
73
HHSearch
74.99
29%
-101
- C1 -
1B0U
4
HISP_SALTY
A:
[5-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
H
V
I
D
L
H
--
K
R
Y
--
G
----
G
----
H
--
E
-----
V
L
-
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
----
Q
-----
N
I
N
L
-----
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
L
-------
R
T
-----
R
----
L
----
T
M
V
F
Q
H
F
N
L
W
-------
S
---
H
M
T
V
L
E
N
----------
V
M
-
E
A
P
I
Q
V
L
G
L
--
S
--
K
H
D
A
R
E
R
A
L
K
-
Y
L
A
K
V
-----
G
I
D
E
R
A
Q
G
---
K
-------
Y
P
V
H
----
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
A
E
-
E
G
K
T
M
V
V
V
T
H
E
M
G
F
A
--
R
H
V
S
S
H
V
-
I
F
L
H
Q
-
G
-
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
----------------------------------------------------------------------------------------------------------------
46
Fugue
74.83
27%
-112
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
--
K
V
F
--
H
QGTR
T
----
I
--
Q
-----
A
L
-
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
----
Q
ELTTL
S
E
S
E
-----
L
----------------
T
K
-------
A
R
-----
R
Q---
I
----
G
M
I
F
Q
H
F
N
L
L
-------
S
S
R
---
T
V
F
G
N
----------
V
A
-
L
P
L
E
L
D
N
-----
T
P
K
D
E
V
K
R
R
V
T
E
-
L
L
S
L
V
-----
G
L
G
D
K
H
-
D
---
S
-------
Y
P
S
N
----
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
--
K
R
I
C
D
C
V
-
A
V
I
-
S
-
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
AEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-----------
74
HHSearch
74.48
31%
-123
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[2-219]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
A
L
S
V
E
N
L
G
--
F
Y
Y
--
Q
----
A
E---
N
--
F
-----
L
F
-
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
E
V
Y
-----------------------------------------------
Q
-----
S
----
I
----
G
F
V
P
Q
F
F
S
S
P
----------
F
A
Y
S
V
L
D
I
----------
V
L
-
M
G
R
S
T
H
I
N
T
F
-
A
K
P
K
S
H
D
Y
Q
V
A
M
Q
-
A
L
D
Y
L
-----
N
L
T
H
L
A
-
K
---
R
-------
E
F
T
S
----
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
--
V
A
I
A
N
K
T
-
L
L
L
-
N
-
K
-
Q
N
F
K
F
G
E
T
R
N
I
L
T
S
E
----------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
74.30
31%
-94
- C1 -
4U02
1
?
D:
[2-224]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
I
I
R
I
R
N
L
H
--
K
W
F
--
G
----
P
----
L
--
H
-----
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
-----
S
V
K
D
-----
D
----------------
R
A
-------
L
R
-----
E
----
I
RREV
G
M
V
F
Q
Q
F
N
L
F
-------
P
H
M
---
T
V
L
E
N
----------
V
T
-
L
A
P
M
R
V
R
R
W
P
-
R
E
K
A
E
K
K
A
L
E
L
----
L
E
R
V
-----
G
I
L
D
Q
A
-
R
---
K
-------
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
---------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.91
31%
-100
- C1 -
4U02
1
?
C:
[1-224]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
P
I
I
R
I
R
N
L
H
--
K
W
F
--
G
----
P
----
L
--
H
-----
V
L
-
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
----
L
-----
S
V
K
D
-----
D
----------------
R
A
-------
L
R
-----
E
----
I
RREV
G
M
V
F
Q
Q
F
N
L
F
-------
P
H
M
---
T
V
L
E
N
----------
V
T
-
L
A
P
M
R
V
R
R
W
P
-
R
E
K
A
E
K
K
A
L
E
L
----
L
E
R
V
-----
G
I
L
D
Q
A
-
R
---
K
-------
Y
P
A
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
---------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
72.60
31%
-114
- C1 -
1JI0
1
?
A:
[6-225]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
E
V
Q
S
L
H
--
V
Y
Y
--
G
----
A
----
I
--
H
-----
A
I
-
K
G
I
D
L
K
V
P
R
G
Q
I
V
T
L
I
G
A
N
G
A
G
K
T
T
T
L
S
A
I
A
G
L
V
R
A
Q
K
G
K
I
I
F
N
G
----
Q
DITN-
K
P
A
H
-----
V
----------------
I
N
-------
R
M
-----
G
----
I
----
A
L
V
P
E
G
R
R
I
F
-------
P
E
L
---
T
V
Y
E
N
----------
L
M
-
M
G
----------
A
Y
N
R
K
D
K
E
G
I
K
R
-
D
L
E
W
I
F
S
L
F
P
R
L
K
E
R
L
-
K
---
Q
-------
L
G
G
T
----
L
S
G
G
E
Q
Q
M
L
A
I
G
R
A
L
M
S
R
P
K
L
L
M
M
D
E
P
S
L
G
L
A
P
I
L
V
S
E
V
F
E
V
I
Q
K
I
N
Q
-
E
G
T
T
I
L
L
V
E
Q
N
A
L
G
A
L
K
V
A
H
Y
G
Y
V
-
L
E
T
-
G
-
Q
--
I
V
L
E
G
K
A
S
E
---------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
72.32
32%
-123
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[2-205]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
A
L
S
V
E
N
L
G
--
F
Y
Y
--
Q
----
A
----
E
--
N
-----
F
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
E
V
-----------------------------------------------
Y
Q
-----
S
----
I
----
G
F
V
P
Q
---
F
F
-------
S
S
P
F
A
Y
S
V
L
D
I
----------
V
L
-
M
G
R
S
T
H
I
N
T
F
-
A
K
P
K
S
H
D
Y
Q
V
A
M
Q
-
A
L
D
Y
L
-----
N
L
T
H
L
A
-
K
---
R
-------
E
F
T
S
----
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
S
Q
N
M
T
V
V
F
T
T
H
Q
P
N
Q
V
--
V
A
I
A
N
K
T
-
L
L
L
-
N
-
K
-
Q
------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
72.31
29%
-98
- C1 -
1OXX
22
?
K:
[2-235]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
I
I
V
K
N
V
S
--
K
V
F
--
K
----
K
GK--
V
--
V
-----
A
L
-
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
----
R
-----
L
V
A
S
-----
N
GKLIVP----------
P
E
-------
D
R
-----
K
----
I
----
G
M
V
F
Q
T
W
A
L
Y
-------
P
N
---
L
T
A
F
E
N
----------
I
A
-
F
P
L
T
N
M
K
M
---
S
--
K
E
E
I
R
K
R
V
E
E
-
V
A
K
I
L
-----
D
I
H
H
V
L
-
N
---
H
-------
F
P
R
E
----
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
--
F
A
I
A
D
R
V
-
G
V
L
V
K
-
G
-
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
-------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
71.94
30%
-101
- C1 -
4YMV
1
?
J:
[1-230]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
F
V
N
D
V
Y
--
K
N
F
--
G
----
S
----
L
--
E
-----
V
L
-
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
----
V
-----
K
I
N
N
-----
G
----------------
K
V
-------
N
I
NKVRQ
K
----
V
----
G
M
V
F
Q
H
F
N
L
F
-------
P
H
L
--
T
A
I
E
N
I
----------
T
L
-
A
P
V
K
V
K
K
------
M
N
K
K
E
A
E
E
L
A
V
D
L
L
A
K
V
-----
G
L
L
D
K
K
-
D
---
Q
-------
Y
P
I
K
----
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
-
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
--
R
E
V
G
D
R
V
-
I
F
M
-
D
-
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.53
30%
-107
- C1 -
1G6H
3
LIVG_METJA
A:
[6-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
R
T
E
N
I
V
--
K
Y
F
--
G
----
E
----
F
--
K
-----
A
L
-
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
-
Y
F
E
----
N
-----
K
D
I
T
-----
N
----------------
K
E
-------
P
A
-----
E
----
L
Y
H
Y
-
G
I
V
----
R
T
F
-------
Q
T
--
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
G
E
I
C
-
P
G
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
E
E
M
V
E
K
-
A
F
K
I
L
-----
E
F
L
K
L
S
-
H
LYD
R
-------
K
A
G
E
----
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
--
L
N
Y
I
D
H
L
Y
V
M
F
-
N
-
G
-
Q
I
I
A
E
G
R
G
E
E
---------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
68.43
30%
-95
- C1 -
1G9X
4
LIVG_METJA
A:
[6-239]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
R
T
E
N
I
V
--
K
Y
F
--
G
----
E
----
F
--
K
-----
A
L
-
D
G
V
S
I
S
V
C
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
V
-
Y
F
E
----
N
-----
K
D
I
T
-----
N
----------------
K
E
-------
P
A
-----
E
----
L
YHY-
G
I
V
----
R
T
F
-------
Q
T
--
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
GE
I
N
-
P
G
E
S
P
L
N
S
L
F
Y
K
K
W
I
P
K
E
E
E
M
V
E
K
-
A
F
K
I
L
-----
E
F
L
K
L
S
-
H
LYD
R
-------
K
A
G
E
----
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
-
K
A
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
--
L
N
Y
I
D
H
L
Y
V
M
F
-
N
-
G
-
Q
I
I
A
E
G
R
G
E
E
---------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
67.33
31%
-84
- C1 -
1L2T
4
Y796_METJA
B:
[1-217]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
K
N
V
T
KT
Y
K
M
--
G
----
E
----
E
II
Y
-----
A
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
----
I
-----
K
T
N
D
-----
L
----------------
D
D
DELTKIR
R
D
-----
K
----
I
----
G
F
V
F
Q
Q
F
N
L
I
PLLTALE
N
V
E
L
P
L
I
F
K
Y
R
----------
G
A
M
S
G
E
E
R
R
K
R
A
L
-
E
C
L
K
M
A
E
L
E
E
-----------------
R
F
A
-
N
---
H
-------
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
----------
N
V
-
A
R
F
-
G
-
E
-
R
I
I
Y
---------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
66.66
31%
-84
- C1 -
1L2T
4
Y796_METJA
A:
[1-217]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
K
N
V
T
K
T
Y
K
M
--
G
----
E
----
E
I
I
Y
-----
A
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
----
I
-----
K
T
N
D
-----
L
----------------
D
D
D
E
L
T
K
I
R
R
D
-----
K
----
I
----
G
F
V
F
Q
Q
F
N
L
I
PLLT
A
L
E
N
V
E
L
P
L
I
F
K
Y
R
----------
G
A
M
S
G
E
E
R
R
K
R
A
L
-
E
C
L
K
M
A
E
L
E
E
-----------------
R
F
A
-
N
---
H
-------
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
----------
N
V
-
A
R
F
-
G
-
E
-
R
I
I
Y
---------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
60.82
30%
-83
- C1 -
3TIF
7
Y796_METJA
A:
[1-217]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
K
L
K
N
V
T
K
T
Y
K
M
--
G
----
E
----
E
I
I
Y
-----
A
L
-
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
----
I
-----
K
T
N
D
-----
L
----------------
D
D
D
E
L
T
K
I
R
R
D
-----
K
----
I
----
G
F
V
F
Q
Q
F
N
L
I
PLLT
A
L
E
N
V
E
L
P
L
I
F
K
Y
R
----------
G
A
M
S
G
E
E
R
R
K
R
A
L
-
E
C
L
K
M
A
E
L
E
E
-----------------
R
F
A
-
N
---
H
-------
K
P
N
Q
----
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
D
G
K
T
V
V
V
V
T
H
D
I
----------
N
V
-
A
R
F
-
G
-
E
-
R
I
I
Y
---------------------------------------------------------------------------------------------------------------------------------