@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1605: (2016-03-26 )
MTIYHFVGIKGSGMSALAQILHDKGFQVQGSDVDKYFFTQKALEEKQIPIMTFSADNIQEGLTIIAGNAFPDTHEEIERALELGLSVIRYHKFLGQLIDGYTSIAITGSHGKTSTTGLLSHVVGAIRPTSYLIGDGTGSGTKDAEYFALEACEYQRHFLAYKPTYAIMTNIDWDHPDYFKSVDDVFNAFETLGKQVKKAVFALGDDAELRKLTLDIPIIYFGFGEENEFQAKNVIKETTGTKFDVYHREEFLSSFEIPAYGDHNVLNALSVIALCDYEGLPVEDVKNELKTFEGVKRRFSITEKGNQVLVDDYAHHPSEIRATVNAARQKYPDKKVVAVFQPHTFTRTRTFLQGFADSLNLADEVYLCDIFGSAREKTGNLTIADLAHKTKGNHIIKEEHTEELLKYPEAVILFMGAGDVQKFQAAYEKVLDHEFLTEADLKKSAIN
Atome Classification :
(20 SA)
.........10........20........30.....---...40.--.......50.-.-...-...--.60-.........70........80......-..90.--------....-.-..-100...-------------....110.......120.--.--...------.------.----130.---------..---.------.---.-----------------------------.----------------------------.--------------140---------.---------.-----------..-----.....150..-------.-.---.-------..160.-----........170...-...----.-180........190--....---..---.200----..---------.-..--..-.210..----.----.--.--.------.220.....-.---.230.......240----.......250-.-......260.......270.....--.---.280-........290......--.300---..----------..----...-..310-.......320.......330.......340.......350.......360........370..-.....380.......390----.---------.-.------.....400....-----------.---..410-------..--------.......420.......430.......440.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
I
Y
H
F
VGIKGS
G
M
S
A
L
A
Q
I
L
HDKG
F
Q
V
QGSDV
D
K
Y
---
F
F
T
Q
K
A
--LEEKQI
P
I
-
M
-
T
-FS
A
-
D
N
I
--QE--G
L
T
I
I
AGNAFPD
T
H
E
E
I
E
R
A
L
E
L
G
L
S
V
-
I
R
Y
H
K
--------
F
L
G
Q
-
L
-ID-GY
T
S
I
A
-------------
I
TGSHGKT
S
T
T
G
L
L
S
H
V
V
--
G
--AIR------P------
T
----
S
-
Y
L
---------
I
G---D------G---T-----------------------------G----------------------------S--------------G-----------T---------K-----------D
A
-----
E
Y
F
A
L
E
A
C
E
Y
-------
Q
-
R
---
H
-------
F
L
A
--Y-----KP
T
Y
A
I
M
TNIDWDH-
P
D
Y
----
F
-
K
-
S
V
D
D
V
F
N
A
F
E
T
L
--
G
K
Q
V
---
K
K
---
A
V
F
-----AL---------G-DD--A
E
-
L
R
K
L
T
L----D----I--
P
--
I
------
I
Y
F
GFGEEN-
E
---
F
Q
A
K
N
V
I
K
ETTGTK----
F
D
V
Y
H
R
E
E
F
L
-
S
-SFEIPAYGD
H
N
V
L
N
A
L
S
V
I
ALCDY--E---GL
P
--
V
E
D
V
K
N
E
L
K
T
F
E
G
V
K
R
R
--FS-----IT----------EK----G
N
Q
-
V
L
V
D
D
-YAH
H
P
S
E
I
R
A
T
V
N
A
A
R
QKYPDK
K
V
V
A
V
FQPHT
F
T
R
T
R
T
F
L
Q
G
F
A
D
SLN-LAD
E
V
Y
L
C
D
IFGS
A
-
R
EKTGNL
T
I
A
D
L
AHKTK-----G---------N-H------II
K
E
E
H
T
E
E
L
L
K-----------Y---P
E
A
---------
V
I
--------
L
F
MGA
G
D
V
Q
K
F
Q
A
A
Y
E
K
V
L
D
H
E
FL
T
E
A
D
L
K
K
SAIN
1
PsiBlast_PDB
94.27
30%
-84
- C1 -
4HV4
2
MURC_YERPE
A:
[26-474]
----
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
N
---
S
V
T
Q
H
L
--
T
A
L
G
A
Q
I
Y
-
F
-
H
-
H
R
P
-
E
N
V
--
L
D
--
A
S
V
V
V
V
S
T
A
I
S
A
D
N
P
E
I
V
A
A
R
E
A
R
I
P
V
-
I
R
R
A
E
--------
M
L
A
E
-
L
-
M
R
-
Y
R
H
G
I
A
-------------
V
A
G
T
H
G
K
T
T
T
T
A
M
L
S
S
I
Y
--
A
E
A
G
L
D
------
P
------
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F
V
N
G
G
-
L
V
---------
K
A
---
A
------
G
---
T
-----------------------------
H
----------------------------
A
--------------
R
-----------
L
---------
G
-----------
S
S
-----
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
-
M
D
T
YQG
D
F
-
E
-
N
L
K
Q
T
F
I
N
F
L
H
N
--
L
P
F
Y
---
G
R
---
A
V
M
-----
C
I
-----------
D
D
--
P
V
-
V
R
E
L
L
P
----
R
----
V
--
G
R
H
I
------
T
T
Y
G
F
S
D
D
A
-
D
---
V
Q
I
A
S
Y
R
Q
E
G
P
Q
G
H
----
F
T
L
R
R
Q
D
K
P
L
-
I
-
E
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
--
E
---
G
I
E
--
D
E
D
I
L
R
A
L
V
G
F
Q
G
T
G
R
R
--
F
D
-----
F
L
G
N
F
P
LAPVNG
K
E
----
G
S
A
-
M
L
V
D
D
-
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
R
I
V
M
L
F
Q
P
H
R
Y
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
S
-
Q
V
D
V
L
L
M
L
D
V
Y
A
A
G
-
E
P
P
I
P
G
A
D
S
R
A
L
C
R
T
I
R
-----
N
---------
R
-
G
KLD
P
I
L
V
P
D
S
E
S
A
P
E
M
L
A
-----------
Q
I
LN
G
E
D
---------
L
I
--------
L
V
Q
G
A
G
N
I
G
K
I
------------------------
30
HHSearch
90.78
26%
-87
* C1 *
1P3D
4
MURC_HAEIN
A:
[19-473]
-
Q
Q
I
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
---
V
V
T
-
Q
R
--
L
A
Q
A
G
A
K
I
-
Y
I
G
-
H
A
E
-
E
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
-
I
Q
R
A
Q
--------
M
L
A
E
-
I
-
M
R
-
F
R
H
G
I
A
-------------
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
--
T
--
Q
A
K
------
L
D-----
P
----
T
-
F
V
---------
N
G
---
G
------
L
---
V
-----------------------------
K
S---------------------------
A
--------------
G
KN
A
H
-------
L
---------
G
-----------
A
S
-----
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
-
M
D
T
----
Y
E
G
-
D
F
E
K
M
K
A
T
Y
V
K
F
--
L
H
N
L
PF-
Y
G
---
L
A
V
-----
M
C
---------
A
-
D
D
--
P
V
-
L
M
E
L
V
P
----
K
VG--
R
--
Q
--
V
------
I
T
Y
G
F
S
E
Q
A
-
D
---
Y
R
I
E
D
Y
E
Q
T
G
F
Q
G
H
----
Y
T
V
I
C
P
N
N
E
R
-
I
-
N
V
L
L
N
V
P
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
---
G
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
--
F
D
-----
Q
L
----------
G
E
F
I
R
P
N
G
K
V
R
L
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
-
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
-
E
A
P
I
V
G
A
D
S
K
S
L
C
R
S
I
R
-----
N
L
GK
V
D
P
I
L
V
S
-
D
------
T
S
Q
L
G
D
V
L
D
Q
I
I
-----------
Q
---
D
G
D
---------
L
I
--------
L
A
Q
G
A
G
S
V
S
K
I
S
R
G
L
A
E
S
W
----------------
3
PsiBlast_PDB
89.74
28%
-79
- C1 -
2F00
1
MURC_ECOLI
A:
[23-478]
----
H
F
V
G
I
G
G
A
G
M
G
G
I
A
E
V
L
A
N
E
G
Y
Q
I
S
G
S
D
L
A
P
N
---
P
V
T
Q
Q
L
--
M
N
L
G
A
T
I
Y
-
F
-
N
-
H
R
P
-
E
N
V
--
R
D
--
A
S
V
V
V
V
S
S
A
I
S
A
D
N
P
E
I
V
A
A
H
E
A
R
I
P
V
-
I
R
R
A
E
--------
M
L
A
E
-
L
-
M
R
-
F
R
H
G
I
A
-------------
I
A
G
T
H
G
K
T
T
T
T
A
M
V
S
S
I
Y
--
A
E
A
G
L
D
------
P
------
T
F
V
N
G
G
-
L
V
---------
K
A
---
A
------
G
---
V
-----------------------------
H
----------------------------
A
--------------
R
-----------
L
---------
G
-----------
H
G
-----
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
A
I
V
T
N
I
E
A
D
H
-
M
D
T
YQGD
F
-
E
-
N
L
K
Q
T
F
I
N
F
L
H
N
--
L
P
F
Y
---
G
R
---
A
V
M
-----
C
V
-----------
D
D
--
P
V
-
I
R
E
L
L
P
----
R
----
V
G
R
Q
--
T
------
T
T
Y
G
F
S
E
D
A
-
D
---
V
R
V
E
D
Y
Q
Q
I
G
P
Q
G
H
----
F
T
L
L
R
Q
D
K
E
P
-
M
-
R
V
T
L
N
A
P
G
R
H
N
A
L
N
A
A
A
A
V
A
V
A
T
E
--
E
---
G
I
D
--
D
E
A
I
L
R
A
L
E
S
F
Q
G
T
G
R
R
--
F
D
-----
F
L
G
E
F
P
LEPVNG
K
S
----
G
T
A
-
M
L
V
D
D
-
Y
G
H
H
P
T
E
V
D
A
T
I
K
A
A
R
A
G
W
P
D
K
N
L
V
M
L
F
Q
P
H
R
F
T
R
T
R
D
L
Y
D
D
F
A
N
V
L
T
-
Q
V
D
T
L
L
M
L
E
V
Y
P
A
G
-
E
A
P
I
P
G
A
D
S
R
S
L
C
R
T
----------------------------
D
P
I
L
V
P
D
P
A
R
-----------
V
---
A
E
M
L
APVLTG
N
D
L
I
--------
L
V
Q
G
A
G
N
I
G
K
I
A
R
S
L
A
E
I
-----------------
5
PsiBlast_PDB
81.30
29%
-77
- C1 -
1P31
2
MURC_HAEIN
A:
[22-407]
----
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
---
V
V
T
Q
R
L
--
A
Q
A
G
A
K
I
Y
-
I
-
G
-
H
A
E
-
E
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
-
I
Q
R
A
Q
--------
M
L
A
E
-
I
-
M
R
-
F
R
H
G
I
A
-------------
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
--
K
L
D
------
P
------
T
------
F
V
---------
N
G
---
G
------
L
---
V
-----------------------------
K
----------------------------
S
--------------
A
-----------
G
---------
K
-----------
N
A
H
L
G
AS
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
-
M
D
T
----
Y
-
E
-
G
--
D
F
E
K
M
K
A
T
Y
--
V
K
F
L
---
H
N
---
L
P
F
Y
G
L
A
V
M
C
---------
A
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D
D
--
P
V
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L
M
E
L
V
P
----
K
----
V
G
R
Q
--
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------
I
T
Y
G
F
S
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Q
A
-
D
---
Y
R
I
E
D
Y
--
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
-
V
-
L
L
N
V
P
--
G
K
H
N
A
L
N
A
T
A
A
L
A
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A
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E
--
E
---
G
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
--
F
D
QL
G
E
F
I
R
----------
P
N
----
G
K
V
-
R
L
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
-
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.29
29%
-73
- C1 -
1P3D
4
MURC_HAEIN
A:
[22-407]
----
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
---
V
V
T
Q
R
L
--
A
Q
A
G
A
K
I
Y
-
I
-
G
-
H
A
E
-
E
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
-
I
Q
R
A
Q
--------
M
L
A
E
-
I
-
M
R
-
F
R
H
G
I
A
-------------
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
--
K
L
D
------
P
------
T
------
F
V
---------
N
G
---
G
------
L
---
V
-----------------------------
K
----------------------------
S
--------------
A
-----------
G
---------
K
-----------
N
A
H
L
G
AS
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
S
V
V
T
N
M
E
P
D
H
-
M
D
T
----
Y
-
E
-
G
--
D
F
E
K
M
K
A
T
Y
--
V
K
F
L
---
H
N
---
L
P
F
Y
G
L
A
V
M
C
---------
A
-
D
D
--
P
V
-
L
M
E
L
V
P
----
K
----
V
G
R
Q
--
V
------
I
T
Y
G
F
S
E
Q
A
-
D
---
Y
R
I
E
D
Y
--
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
-
V
-
L
L
N
V
P
--
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
---
G
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
--
F
D
QL
G
E
F
I
R
----------
P
N
----
G
K
V
-
R
L
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
-
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.75
28%
-79
- C1 -
1GQY
2
MURC_HAEIN
A:
[22-407]
----
H
F
I
G
I
G
G
A
G
M
S
G
I
A
E
I
L
L
N
E
G
Y
Q
I
S
G
S
D
I
A
D
G
---
V
V
T
Q
R
L
--
A
Q
A
G
A
K
I
Y
-
I
-
G
-
H
A
E
-
E
H
I
--
E
G
--
A
S
V
V
V
V
S
S
A
I
K
D
D
N
P
E
L
V
T
S
K
Q
K
R
I
P
V
-
I
Q
R
A
Q
--------
M
L
A
E
-
I
-
M
R
-
F
R
H
G
I
A
-------------
V
A
G
T
H
G
K
T
T
T
T
A
M
I
S
M
I
Y
T
Q
A
--
K
L
D
------
P
------
T
------
F
V
---------
N
G
---
G
------
L
---
V
-----------------------------
K
----------------------------
S
--------------
A
-----------
G
---------
K
-----------
N
A
H
L
G
AS
R
Y
L
I
A
E
A
D
E
S
-------
D
-
A
---
S
-------
F
L
H
--
L
-----
Q
P
M
V
S
V
V
T
N
M
E
P
D
--------------------
D
F
E
K
M
--
K
A
T
Y
---
V
K
---
F
L
H
-----
N
L
PFY
G
L
A
V
M
C
A
-
D
D
--
P
V
-
L
M
E
L
V
P
----
K
----
V
G
R
Q
--
V
------
I
T
Y
G
F
S
E
Q
A
-
D
---
Y
R
I
E
D
Y
--
E
Q
T
G
F
Q
G
H
Y
T
V
I
C
P
N
N
E
R
I
N
-
V
-
L
L
N
V
P
--
G
K
H
N
A
L
N
A
T
A
A
L
A
V
A
K
E
--
E
---
G
I
A
--
N
E
A
I
L
E
A
L
A
D
F
Q
G
A
G
R
R
--
F
D
QL
G
E
F
I
R
----------
P
N
----
G
K
V
-
R
L
V
D
D
-
Y
G
H
H
P
T
E
V
G
V
T
I
K
A
A
R
E
G
W
G
D
K
R
I
V
M
I
F
Q
P
H
R
Y
S
R
T
R
D
L
F
D
D
F
V
Q
V
L
S
-
Q
V
D
A
L
I
M
L
D
V
Y
A
A
G
------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
76.33
28%
-96
- C1 -
3EAG
2
?
A:
[4-326]
M
K
H
I
H
I
I
G
I
G
G
T
F
M
G
G
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
Y
---
P
P
M
S
T
Q
--
L
E
A
L
G
I
D
V
-
Y
E
G
-
F
D
A
-
A
Q
L
DE
F
K
--
A
D
V
Y
V
I
G
N
V
A
K
R
G
M
D
V
V
E
A
I
L
N
L
G
L
P
Y
-
I
S
G
P
Q
--------
W
L
S
E
-
N
-
V
L
H
H
H
W
V
L
G
-------------
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
--
E
--
Y
A
G
------
L
A
P
----
G
----
F
-
L
I
---------
G
G
---
V
------
P
ENF
G
-----------------------------
V
----------------------------
S
A-------------
R
-----------
L
PQTPRQDPN
S
-----------
Q
S
-----
P
F
F
V
I
E
A
D
E
Y
-------
D
-
T
---
A
FFDKRSK
F
V
H
--
Y
-----
R
P
R
T
A
V
L
N
N
L
E
F
D
H
-
A
D
I
----
F
-
A
-
D
L
G
A
I
Q
T
Q
F
H
Y
L
--
V
R
T
V
PS-
E
G
---
L
I
V
-----
C
N
---------
G
-
R
Q
--
Q
S
-
L
Q
D
T
L
D
----
K
GCW-
T
--
P
--
V
------
E
K
F
G
T
E
H
---
G
---
W
Q
A
G
E
A
N
--
A
-
D
G
S
----
F
D
V
L
L
D
G
K
T
A
-
G
-
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
--
V
---
G
V
D
--
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
73.11
25%
-100
- C1 -
3EAG
2
?
A:
[20-326]
----------------
L
A
A
I
A
K
E
A
G
F
E
V
S
G
C
D
A
K
M
Y
---
P
P
M
S
T
Q
--
L
E
A
L
G
I
D
V
-
Y
-
E
G
F
D
A
-
A
Q
L
--
D
E
FK
A
D
V
Y
V
I
G
N
V
A
K
R
G
M
D
V
V
E
A
I
L
N
L
G
L
P
Y
-
I
S
G
P
Q
--------
W
L
S
E
N
V
-
L
H
-
H
H
W
V
L
G
-------------
V
A
G
T
H
G
K
T
T
T
A
S
M
L
A
W
V
L
E
Y
A
--
G
L
A
------
P
-----------
G
-
F
L
---------
I
G
GVP
E
------
N
---
F
-----------------------------
G
----------------------------
V
--------------
S
-----------
A
---------
R
LPQTPRQDPNS
Q
S
-----
P
F
F
V
I
E
A
D
E
Y
DTAFFDK
R
-
S
---
K
-------
F
V
H
--
Y
-----
R
P
R
T
A
V
L
N
N
L
E
F
D
H
-
A
D
I
----
F
-
A
-
D
L
G
A
I
Q
T
Q
F
H
Y
L
--
V
R
T
V
P--
S
E
---
G
L
I
-----
V
C
---------
N
-
G
R
--
Q
Q
-
S
L
Q
D
T
L
----
D
K
GCW
T
--
P
--
V
------
E
K
--
F
G
T
E
H
-
G
---
W
Q
A
G
E
A
N
A
D
G
S
-------
F
D
V
L
L
D
G
K
T
A
-
G
-
R
V
K
W
D
L
M
G
R
H
N
R
M
N
A
L
A
V
I
A
A
A
R
H
--
V
---
G
V
D
--
I
Q
T
A
C
E
A
L
G
A
F
K
N
V
K
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
70.83
21%
-68
- C1 -
3LK7
3
MURD_STRA5
A:
[9-433]
N
K
K
V
L
V
L
G
L
A
R
S
G
E
-
A
A
A
R
L
L
A
K
L
G
A
I
V
T
V
N
D
G
K
P
F
DEN
P
T
A
-
Q
S
--
L
L
E
E
G
I
K
V
-
V
C
G
-
S
H
P
L
E
L
L
D
-
E
D
--
F
C
Y
M
I
K
N
P
G
I
P
Y
N
N
P
M
V
K
K
A
L
E
K
Q
I
P
V
-
L
T
E
V
E
--------
L
A
Y
L
-
V
--
S
-
E
S
Q
L
I
G
-------------
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
--
N
--
A
G
G
------
Q
------
R
----
G
-
L
L
---------
A
G
---
N
------
I
---
G
-----------------------------
F
----------------------------
P
--------------
A
-----------
S
E
V
V
Q
A
A---
N
-----------
D
K
-----
D
T
L
V
M
E
L
S
S
F
-------
Q
-
L
M
--
G
-------
V
K
E
--
F
-----
R
P
H
I
A
V
I
T
N
L
M
P
T
H
-
L
D
Y
----
H
-
G
-
S
F
E
D
Y
V
A
A
K
W
N
I
--
Q
N
Q
M
SS-
S
D
---
F
L
V
-----
L
N
---------
F
-
N
Q
--
G
I
-
S
K
E
L
A
K
----
T
TK--
A
--
T
--
I
------
V
P
F
S
T
T
E
K
V
-
D
G
--
A
Y
V
Q
D
-------
K
Q
----
L
F
--
Y
K
G
E
N
I
-
M
S
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
--
A
---
G
I
S
--
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
--
L
Q
-----
S
L
----------
G
K
----
V
H
G
I
S
F
Y
N
D
-
S
--
K
S
T
N
I
L
A
T
Q
K
A
L
S
G
F
-
D
N
T
K
V
I
L
I
A
G
G
--
L
D
R
G
N
E
F
-
D
E
L
I
P
D
I
T
-
G
L
K
H
M
V
V
L
G
E
S
A
S
R
V
K
R
A
A
Q
--
K
A
G
V
T
Y
S
D
A
----------------
L
-
D
------
V
R
D
A
V
H
K
A
Y
E
V
A
-----------
Q
---
Q
G
D
---------
V
I
--------
L
L
S
P
A
N
A
S
W
D
M
Y
K
N
---------------------
36
HHSearch
62.31
16%
-70
- C1 -
2VOS
8
?
A:
[62-474]
--------------------------------------------------------------------------------------------------------------------------
R
-
S
Y
P
S
I
H
-------------
I
A
G
T
N
G
K
T
S
V
A
R
M
V
D
A
L
V
--
T
--
A
L
H
R
R
T
G
R
T
T
------
S
----
P
-
H
L
QSPVERISI
D
G
---
K
P-----
I
---
S
-----------------------------
P
A
Q
Y
V
A
T
Y
R
E
I
E
P
L
V
A
L
I
D
Q
Q
S
Q
A
S----
P
AMS
K
F
E
V
L
T
A
M
---
A
F
A
A
F
-------
A
D
--------
A
-----------
P
V
-----
D
V
A
V
V
E
V
G
M
G
-------
G
-
R
WD-
A
-------
T
N
V
--
I
-----
N
A
P
V
A
V
I
T
P
I
S
I
D
H
-
V
D
Y
----
L
-
G
A
D
I
A
G
I
A
G
E
K
A
G
I
--
I
T
R
A
PSP
D
T
---
V
A
V
-----
I
G
---------
R
-
Q
V
--
P
K
-
V
M
E
V
L
L
----
A
E
S
V
R
A
--
D
--
A
------
S
V
A
R
E
--
D
S
-
E
---
F
A
V
L
R
R
Q
I
A
V
G
G
Q
V
----
L
Q
L
Q
G
L
G
G
V
Y
-
S
-
D
I
Y
L
P
L
H
G
E
H
Q
A
H
N
A
V
L
A
L
A
S
V
E
A
--
F
F
GA
Q
L
D
--
G
D
A
V
R
A
G
F
A
A
V
-
T
S
P
G
R
--
L
E
-----
R
M
----------
R
S
-----
A
P
-
T
V
F
I
D
-
A
A
H
N
P
A
G
A
S
A
L
A
Q
T
L
A
H
E
F
D
F
R
F
L
V
G
V
L
S
V
L
---
G
D
K
D
-
V
D
G
I
L
A
A
L
E
P
V
F
D
S
V
V
V
T
H
N
G
S
P
R
A
L
D
V
--
E
A
L
A
L
A
A
G
E
R
F
G
PDR
V
R
T
A
--------
E
-
N
------
L
R
D
A
I
D
V
A
T
S
L
V
D
D
A
A
A
DPDVAG-----
R
T
---------
G
I
--------
V
I
T
G
S
V
V
T
---------------------------
9
PsiBlast_PDB
62.05
26%
-79
- C1 -
3LK7
2
MURD_STRA5
A:
[77-314]
-----------------------------------------------------------------------------
I
K
N
P
G
I
P
Y
N
N
P
M
V
K
K
A
L
E
K
Q
I
P
V
-
L
T
E
V
E
---------
L
A
Y
-
L
-
V
S
-
E
S
Q
L
I
G
-------------
I
T
G
S
N
G
K
T
T
T
T
T
M
I
A
E
V
L
--
N
--
A
G
G
------
Q
------
R
----
G
-
L
L
---------
A
G
---
N
IGFP
A
S
E
---
V
-----------------------------
V
----------------------------
Q
--------------
A
-----------
A
---------
N
-----------
D
K
-----
D
T
L
V
M
E
L
S
S
F
-------
Q
-
L
---
M
-------
G
V
K
E-
F
-----
R
P
H
I
A
V
I
T
N
L
M
P
T
H
-
L
D
Y
----
H
-
G
-
S
F
E
D
Y
V
A
A
K
W
N
I
--
Q
N
Q
M
---
S
S
---
S
D
F
-----
L
V
L
N
FNQ----
G
-
I
S
--
K
E
-
L
A
K
T
T
-----
K
----
A
--
T
--
I
------
V
P
F
S
T
T
E
K
V
-
D
G
A
Y
V
Q
D
K
Q
L
F
--------------
Y
K
G
E
N
I
M
-
S
-
V
D
D
I
G
V
P
G
S
H
N
V
E
N
A
L
A
T
I
A
V
A
K
L
--
A
---
G
I
S
--
N
Q
V
I
R
E
T
L
S
N
F
G
G
V
K
H
R
--
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
61.10
16%
-65
- C1 -
1O5Z
8
?
A:
[51-439]
----------------------------------------------------------------------------------------------------------------------------
E
Y
K
T
I
H
-------------
I
G
G
T
N
G
K
G
S
V
A
N
M
V
S
N
I
L
--
V
--
S
Q
G
------
Y
R
V
G
S
Y
Y
S
----
P
-
H
L
---------
S
T
---
F
RERIR-
L
---
N
EEYIS
E
E
D
V
V
K
I
Y
E
T
M
E
P
I
L
N
E
L
D
KEEIF
S
----------------------------
P
S
F
F
E
V
V
T
A
M
A
F
L
Y
F
A
-----------
E
---------
K
-----------
N
V
-----
D
I
A
V
L
E
V
G
L
G
-------
G
R
L
D--
A
-------
T
N
V
--
V
-----
F
P
L
C
S
T
I
V
T
V
D
R
-------------Y
T
I
E
Q
I
A
W
E
K
S
G
I
--
I
K
E
R
--------
V
P
L
-----
V
T
---------
G
E
R
K
--
R
E
-
A
L
K
V
M
E
D
V
A
R
K
----
K
--
S
--
S
------
R
M
Y
V
I
D
K
D
F
-
S
---
V
K
V
K
S
L
K
--
L
H
E
N
R
----
F
D
Y
C
G
E
-
N
T
F
-
E
-
D
L
V
L
T
M
N
G
P
H
Q
I
E
N
A
G
V
A
L
K
T
L
E
A
--
T
---
G
L
P
LS
E
K
A
I
R
E
G
L
K
N
A
K
N
-
L
G
R
--
F
E
-----
I
L
----------
E
K
-----
N
G
K
M
Y
I
L
D
-
G
A
H
N
P
H
G
A
E
S
L
V
R
S
L
K
L
Y
F
N
G
E
P
L
S
L
V
I
G
I
L
---
D
D
K
N
-
R
E
D
I
L
R
K
Y
T
G
I
F
E
R
V
I
V
T
R
V
P
S
P
R
M
K
D
M
--
N
S
L
V
D
M
A
K
K
F
F
K
-----
N
---------
V
E
V
------
I
E
D
P
L
E
A
I
---
E
-----------
S
---
T
E
R
---------
A
T
--------
V
V
T
G
S
L
---
F
L
V
G
Y
V
R
E
F
L
T
T
G
K
I
N
E
E
--------
39
HHSearch
58.96
18%
-72
- C1 -
3NRS
7
?
A:
[51-428]
----------------------------------------------------------------------------------------------------------------------------
A
P
K
I
F
T
-------------
V
A
G
T
N
G
K
G
T
T
C
C
T
L
E
A
I
L
--
L
--
A
A
G
------
L
------
R
----
V
G
V
Y
S
S
-------
P
H
---
L
------
L
---
R
YTE--------------------------
R
VRIQG
Q
E
L
S
E
A
E
H
S
H
S
F
A
Q
I
E
A
G
R
GD
I
S
L
T
Y
F
E
F
G
T
L
S
A
L
Q
L
F
K
-----------
Q
---------
A
-----------
K
L
-----
D
V
V
I
L
E
V
G
L
G
-------
G
-
R
LD-
A
-------
T
N
I
--
V
-----
D
S
D
V
A
A
I
T
S
I
A
L
D
H
-
T
D
W
----
L
-
G
Y
D
R
E
S
I
G
R
E
K
A
G
V
--
F
R
G
G
----
K
---
P
A
V
-----
V
G
---------
E
-
P
D
M-
P
Q
S
I
A
D
V
A
A
----
E
L
G--
A
--
Q
--
L
Y
R
R
DVA
W
K
F
S
Q
-------------------
N
G
W
H
----
W
Q
C
G
----
E
R
-
Q
-
L
T
G
L
P
V
P
N
-
V
P
L
A
N
A
A
T
A
L
A
V
L
H
Y
S
E
L
---
P
L
S
--
D
E
A
I
R
Q
G
L
Q
A
A
-
S
L
P
G
R
--
F
Q
-----
V
V
----------
S
E
-----
Q
P
-
L
L
I
L
D
-
V
A
H
N
P
H
A
A
R
Y
L
V
N
R
L
A
Q
V
I
--
G
K
V
R
A
V
V
G
M
L
---
S
D
K
D
-
I
A
G
T
L
A
C
L
S
E
R
V
D
E
W
Y
C
A
P
L
E
G
P
R
G
A
S
------
A
G
Q
L
A
E
H
L
V
-----
S
A
R
Q
F
-----
S
-
D
------
V
E
T
A
W
R
Q
A
M
Q
D
A
-----------
D
---
T
Q
D
---------
V
V
--------
I
V
C
G
S
F
H
T
V
--------------------------
10
PsiBlast_PDB
58.40
25%
-59
- C1 -
4QDI
4
?
A:
[123-373]
--------------------------------------------------------------------------------------------------------------------------------
I
A
-------------
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
--
S
--
R
L
A
------
P
------
T
-------
L
---------
I
T
---
R
------
G
---
N
-----------------------------
L
----------------------------
N
--------------
N
D
L
G
V
P
M
M
L
L
E
L
R
---------
K
-----------
E
H
-----
Q
Y
A
V
M
E
L
G
A
N
-------
H
-
Q
---
G
-------
E
I
D
--
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
-
L
G
E
----
F
-
G
-
G
R
D
G
I
C
R
A
K
S
E
I
--
Y
R
H
I
---
L
P
Q
G
V
A
I
V
-----
P
Q
---------
Q
-
D
D
F
T
A
E
-
I
R
E
A
A
K
----
S
----
H
--
Q
--
I
------
M
S
F
G
E
G
G
D
V
-
F
---
A
T
E
I
E
L
L
P
Q
S
A
N
F
Q
----
L
---
H
T
P
Q
G
S
-
S
-
F
V
R
L
P
F
A
G
E
H
N
V
Q
N
A
T
A
A
V
A
F
A
L
A
--
L
---
G
V
S
--
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
--
L
N
-----
F
I
----------
Q
K
----
A
P
H
-
L
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
L
Q
Q
N
G
I
K
V
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.49
21%
-61
- C1 -
3ZM5
1
?
A:
[10-333]
--------------------------
Q
V
V
G
A
K
N
D
I
S
---
I
F
E
D
T
Q
--
L
E
K
A
E
--------
F
D
S
-
R
L
I
--
G
T
--
G
D
L
F
V
P
L
K
G
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
E
V
S
N
H
P
Y
I
L
V
D
D
-
V
-
L
T
-
A
F
Q
S
L
A
S
Y
Y
L
E
K
TT
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
--
S
--
T
R
Y
------
K
------
T
----
Y
-
K
T
---------
Q
G
---
N
------
Y
---
N
-----------------------------
N
----------------------------
E
I
G
L
P
Y
T
V
L
H
-----
M
-----------
P
---------
E
-----------
G
T
-----
E
K
L
V
L
E
M
G
Q
D
-------
H
-
L
G
D
I
H
-------
L
L
S
E
L
A
-----
R
P
K
T
A
I
V
T
L
V
G
E
A
H
-
L
A
F
----
F
-
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
AD
G
M
A
S
---
G
S
---
L
L
L
-----
A
P
---------
A
-
D
P
--
I
V
-
E
D
Y
L
P
I
----
D
----
K
--
K
--
V
------
V
R
F
G
Q
G
A
E
L
-
E
---------
I
T
D
L
V
E
R
K
----
D
S
L
T
F
K
A
N
F
L
E
Q
-
A
L
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
---
G
V
S
--
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
-----
K
A
----------
A
N
----
G
A
D
-
I
L
S
D
V
-
Y
N
A
N
P
T
A
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.84
25%
-58
- C1 -
4ZIY
3
?
A:
[125-385]
--------------------------------------------------------------------------------------------------------------------------------
I
A
-------------
L
T
G
S
S
G
K
T
T
T
K
E
M
L
G
S
I
L
--
S
--
R
L
A
------
P
------
T
-------
L
---------
I
T
---
R
------
G
---
N
-----------------------------
L
----------------------------
N
--------------
N
D
L
G
V
P
M
M
L
L
E
L
R
---------
K
-----------
E
H
-----
Q
Y
A
V
M
E
L
G
A
N
-------
H
-
Q
---
G
-------
E
I
D
--
Y
T
S
K
I
V
Q
P
H
V
A
G
I
L
N
I
G
T
A
H
--------
F
-
G
-
G
R
D
G
I
C
R
A
K
S
E
I
--
Y
R
H
I
---
L
P
Q
G
V
A
I
V
-----
P
Q
---------
Q
-
D
D
F
T
A
E
-
I
R
E
A
A
K
----
S
----
H
--
Q
--
I
------
M
S
F
G
A
G
G
D
V
-
F
---
A
T
E
I
E
L
L
P
Q
S
A
N
F
Q
----
L
---
H
T
P
Q
G
S
-
S
-
F
V
R
L
P
F
A
G
E
H
N
V
Q
N
A
T
A
A
V
A
F
A
L
A
--
L
---
G
V
S
--
L
E
D
I
V
K
G
L
E
Q
A
Q
G
A
K
G
R
--
L
N
-----
F
I
----------
Q
K
----
T
P
H
-
L
F
I
D
D
T
Y
N
A
N
P
T
S
M
R
A
A
A
Q
V
L
L
Q
Q
N
G
I
K
V
M
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
56.79
21%
-63
- C1 -
2AM2
1
?
A:
[10-330]
--------------------------
Q
V
V
G
A
K
N
D
I
S
---
I
F
-------
E
D
T
Q
L
E
K
-
A
-
E
-
F
D
S
-
R
L
I
--
G
T
--
G
D
L
F
V
P
L
K
G
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
EVSNHP
Y
I
L
V
D
D
-
V
-
L
T
-
A
F
Q
S
L
A
S
Y
Y
L
E
K
T
T
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
--
S
--
T
R
Y
------
K
------
T
----
Y
-
K
T
---------
Q
G
---
N
------
Y
---
N
-----------------------------
N
----------------------------
E
I
G
L
P
Y
T
V
L
H
-----
M
-----------
P
---------
E
-----------
G
T
-----
E
K
L
V
L
E
M
G
Q
D
-------
H
-
L
G
D
I
H
-------
L
L
S
E
L
A
-----
R
P
K
T
A
I
V
T
L
V
G
E
A
H
-
L
A
F
----
F
-
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
AD
G
M
A
S
---
G
S
---
L
L
L
-----
A
P
---------
A
-
D
P
--
I
V
-
E
D
Y
L
P
I
----
D
----
K
--
K
--
V
------
V
R
F
G
Q
G
A
E
L
-
E
---------
I
T
D
L
V
E
R
K
----
D
S
L
T
F
K
A
N
F
L
E
Q
-
A
L
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
---
G
V
S
--
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
-----
K
A
----------
A
N
----
G
A
D
-
I
L
S
D
V
-
Y
N
A
N
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
56.75
21%
-63
- C1 -
2AM1
2
?
A:
[10-330]
--------------------------
Q
V
V
G
A
K
N
D
I
S
---
I
F
-------
E
D
T
Q
L
E
K
-
A
-
E
-
F
D
S
-
R
L
I
--
G
T
--
G
D
L
F
V
P
L
K
G
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
EVSN
H
P
Y
I
L
V
D
D
-
V
-
L
T
-
A
F
Q
S
L
A
S
Y
Y
L
E
K
T
T
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
--
S
--
T
R
Y
------
K
------
T
----
Y
-
K
T
---------
Q
G
---
N
------
Y
---
N
-----------------------------
N
----------------------------
E
I
G
L
P
Y
T
V
L
H
-----
M
-----------
P
---------
E
-----------
G
T
-----
E
K
L
V
L
E
M
G
Q
D
-------
H
-
L
G
D
I
H
-------
L
L
S
E
L
A
-----
R
P
K
T
A
I
V
T
L
V
G
E
A
H
-
L
A
F
----
F
-
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
AD
G
M
A
S
---
G
S
---
L
L
L
-----
A
P
---------
A
-
D
P
--
I
V
-
E
D
Y
L
P
I
----
D
----
K
--
K
--
V
------
V
R
F
G
Q
G
A
E
L
-
E
---------
I
T
D
L
V
E
R
K
----
D
S
L
T
F
K
A
N
F
L
E
Q
-
A
L
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
---
G
V
S
--
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
-----
K
A
----------
A
N
----
G
A
D
-
I
L
S
D
V
-
Y
N
A
N
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
55.08
21%
-59
- C1 -
3ZM6
1
?
A:
[10-333]
--------------------------
Q
V
V
G
A
K
N
D
I
S
---
I
F
E
D
T
Q
--
L
E
K
A
E
--------
F
D
S
-
R
L
I
--
G
T
--
G
D
L
F
V
P
L
K
G
A
R
D
G
H
D
F
I
E
T
A
F
E
N
G
A
A
V
-
T
L
S
E
K
E
V
S
N
H
P
Y
I
L
V
D
D
-
V
-
L
T
-
A
F
Q
S
L
A
S
Y
Y
L
E
K
T
T
V
D
V
F
A
V
T
G
S
N
G
K
T
T
T
K
D
M
L
A
H
L
L
--
S
--
T
R
Y
------
K
------
T
----
Y
-
K
T
---------
Q
G
---
N
------
Y
---
N
-----------------------------
N
----------------------------
E
I
G
L
P
Y
T
V
L
H
-----
M
-----------
P
---------
E
-----------
G
T
-----
E
K
L
V
L
E
M
G
Q
D
-------
H
-
L
G
D
I
H
-------
L
L
S
E
L
A
-----
R
P
K
T
A
I
V
T
L
V
G
E
A
H
-
L
A
F
----
F
-
K
-
D
R
S
E
I
A
K
G
K
M
Q
I
AD
G
M
A
S
---
G
S
---
L
L
L
-----
A
P
---------
A
-
D
P
--
I
V
-
E
D
Y
L
P
I
----
D
----
K
--
K
--
V
------
V
R
F
G
Q
G
A
E
L
-
E
---------
I
T
D
L
V
E
R
K
----
D
S
L
T
F
K
A
N
F
L
E
Q
-
A
L
D
L
P
V
T
G
K
Y
N
A
T
N
A
M
I
A
S
Y
V
A
L
Q
--
E
---
G
V
S
--
E
E
Q
I
R
L
A
F
Q
H
L
E
L
T
R
N
R
T
E
W
K
-----
K
A
----------
A
N
----
G
A
D
-
I
L
S
D
V
-
Y
N
A
N
P
T
A
M
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
54.96
31%
6
- C1 -
1J6U
-
MURC_THEMA
A:
[5-431]
-----
F
V
G
I
G
G
I
G
M
S
A
V
A
L
H
E
F
S
N
G
N
D
V
Y
G
S
N
I
E
E
------
T
E
R
T
A
Y
L
R
K
L
G
I
P
I
F
V
-
P
-
H
S
A
-
D
N
W
--
Y
D
--
P
D
L
V
I
K
T
P
A
V
R
D
D
N
P
E
I
V
R
A
R
M
E
R
V
P
I
E
N
R
L
H
Y
--------
F
R
D
T
-
L
K
R
E
-
K
K
E
E
F
A
-------------
V
T
G
T
D
G
K
T
T
T
T
A
M
V
A
H
V
L
--
K
--
H
L
R
KS----
P
------
T
----
V
-
F
L
GG-------
I
M
---
D
------
S
---
L
-----------------------------
E
----------------------------
H
--------------
G
-----------
N
Y
E
-------
K
-----------
G
N
-----
G
P
V
V
Y
E
L
D
E
S
-------
E
-
E
---
F
-------
F
S
E
--
F
-----
S
P
N
Y
L
I
I
T
N
A
R
G
D
H
L
E
N
Y
----
G
-
N
-
S
L
T
R
Y
R
S
A
F
E
K
I
--
S
R
N
T
---
D
L
---
V
V
T
-----
F
A
---------
E
-
D
E
--------
L
T
S
----
H
----
L
--
G
--
D
------
V
T
F
G
V
K
K
G
T
Y
T
---
L
E
M
R
S
A
S
R
A
E
Q
K
A
M
----
V
E
K
N
G
K
R
Y
L
E
-
L
-
K
L
K
V
P
G
F
--
H
N
V
L
N
A
L
A
V
I
A
L
F
D
S
--
L
---
G
Y
D
--
L
A
P
V
L
E
A
L
E
E
F
R
G
V
H
R
R
--
F
S
-----
I
A
FHD-------
P
E
----
T
N
I
-
Y
V
I
D
D
-
Y
A
H
T
P
D
E
I
R
N
L
L
Q
T
A
K
E
V
F
E
N
E
K
I
V
V
I
F
Q
P
H
R
--------
G
N
F
A
K
A
L
Q
-
L
A
D
E
V
V
V
T
E
V
Y
D
----------
S
G
K
M
I
W
D
S
L
K
-----
S
------------------
L
G
K
E
A
Y
F
V
E
K
L
P
-----------
E
---
L
E
K
---------
V
I
S
V
S
E
N
T
V
F
L
F
V
G
A
G
D
I
---------------------------