@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1713: (2016-03-28 )
MFGTTTIGIDLGTANILVYSKEKGIILNEPSVVALNTNDGTVLAIGQEAKEMIGKTPTSISAVRPMKDGVIADFDLTSGLLREIMRRISVSGVRKPNVVVCTPTGATSVERRAISDAVRSTGARSVVLIEEPVAAAIGADLPVAEPVANVIVDIGGGTSEIAIISYGGVVSSTSIRTGGDHMDEEIIQYIRKNYNLLIGQTTAERIKMELGYAPIEHVTQTADIRGRDLLTGLPKTIQVSSTEIQSALAETLQRILEAIRNTLELCPPELSGDIVDRGIILSGGGSLLQGFRDWLVEEIDVPVHMAPSPLESVAIGTGRSLVFADKLAKN
Atome Classification :
(20 SA)
.........10..--......20..-.---.---------.--------.---------.------.------30.......-.------40-..--.---....----------..50.......--------------------------------------.60..--------------------..-.-----------------.-------------------------------..-------------70......---------------------..80.......-.90-.-....--...100.......110......-.120........130.....--..140.-.-------.....---150-.......160..-----...-.---.--170.-----.--...----..-------..180.......190...---..-------------.-------------.-------------200.......210-..-...-...220-.--------..------------..-..-----..230---....--....240..---.....250-----.-.......260..---.....270.......280.......290.......300.---------.--------------------......310.......320..-.....330
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFG
T
T
T
I
G
I
DLG
T
--
A
N
I
L
V
Y
SKEK-
G
---
I
---------
I
--------L---------N------E------P
S
V
V
A
L
NTN-D------
G
--
T
V
--
L
---
A
I
G
Q
----------
E
A
K
E
M
IGKTPT--------------------------------------SISAV--------------------RP-M-----------------K-------------------------------D
G
-------------
V
I
AD
F
D
L
T
---------------------
S
G
L
L
R
E
I
M
R
R
I-SVS-G-VRKP--
N
V
V
V
CTPTGA
T
S
V
E
R
R
A
I
S
D
A
V
-
R
ST-G
A
R
S
V
V
L
IEEP
V
A
A
AI--GADLPV-A-------E
P
V
A
N
---
V
I
V
-DIGGGT
S
E
I
A
I
I
-----
S
YG-
G
---
V
--
V
--
S
-----S--TSI----RT-------GGDH
M
D
E
E
I
I
Q
Y
I
R
KNY
N
---
L
L
-------------I-------------G-------------QT
T
A
E
R
I
K
M
ELG--YA-
P
I
E
-
H
V
T
Q---T--------AD------------IR-G
R
-----
D
L
LT----GLP
K
--
T
I
Q
V
S
S
T
E
I
---
Q
S
A
L
A
E
T
------
L
-
Q
R
I
L
E
A
I
R
N
T
L
E---LCPPELSGDIVDR
G
I
I
LSG
G
G
S
L
L
Q
G
F
R
D
W
L
V
E
EID-VP---------V--------------------HMAPS
P
L
E
S
VAIGTG
R
S
L
V
F
A
-
D
K
LAKN
21
PsiBlast_CBE
97.48
50%
-102
- C4 -
4CZJ
2
?
B:
[5-325]
-----
D
I
A
I
D
L
G
T
--
A
N
T
L
I
Y
Q
K
G
K
-
G
---
I
---------
V
--------
L
---------
N
------
E
------
P
S
V
V
A
L
R
N
V
-
G
------
G
RK
V
V
--
H
---
A
V
G
I
----------
E
A
K
Q
M
L
G
R
T
P
G
--------------------------------------
H
M
E
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
F
E
V
A
---------------------
E
E
M
I
K
Y
F
I
R
K
V
H
N
--------
P
--
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
-
L
N
A
-
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
--
G
A
G
L
P
I
-
H
-------
E
P
T
G
S
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
-----
S
L
S
-
G
---
I
--
V
--
Y
-----
S
--
R
S
V
----
R
V
-------
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
---
L
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
TA
R
A
-
P
A
D
-
G
E
G
L
---
S
--------
I
D
------------
V
K
-
G
R
-----
D
L
M
Q
----
G
V
P
R
--
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
---
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
---------
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
----------
2
PsiBlast_PDB
96.84
50%
-105
- C4 -
4CZL
2
?
A:
[3-325]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
I
Y
Q
K
G
K
-
G
---
I
---------
V
--------
L
---------
N
------
E
------
P
S
V
V
A
L
R
N
V
-
G
------
G
RK
V
V
--
H
---
A
V
G
I
----------
E
A
K
Q
M
L
--------------------------------------------
M
E
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
F
E
V
A
---------------------
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
-
G
-
S
G
N
P
--
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
-
L
N
A
-
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
--
G
A
G
L
P
I
-
H
-------
E
P
T
G
S
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
-----
S
L
S
-
G
---
I
--
V
--
Y
-----
S
--
R
S
V
----
R
V
-------
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
---
L
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
TA
R
A
-
P
A
D
-
G
E
G
L
---
S
--------
I
D
------------
V
K
-
G
R
-----
D
L
M
Q
----
G
V
P
R
--
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
---
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
---------
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
----------
22
PsiBlast_CBE
96.83
50%
-104
- C4 -
4CZM
2
?
B:
[3-325]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
I
Y
Q
K
G
K
-
G
---
I
---------
V
--------
L
---------
N
------
E
------
P
S
V
V
A
L
R
N
V
-
G
------
G
RK
V
V
--
H
---
A
V
G
I
----------
E
A
K
Q
M
L
G
R
T
P
G
--------------------------------------
H
M
E
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
F
E
V
A
---------------------
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
-
G
-
S
G
N
P
--
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
-
L
N
A
-
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
--
G
A
G
L
P
I
-
H
-------
E
P
T
G
S
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
-----
S
L
S
-
G
---
I
--
V
--
Y
-----
S
--
R
S
V
----
R
V
-------
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
---
L
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
TA
R
A
-
P
A
D
-
G
E
G
L
---
S
--------
I
D
------------
V
K
-
G
R
-----
D
L
M
Q
----
G
V
P
R
--
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
---
A
T
P
P
E
L
A
D
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
---------
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
----------
1
PsiBlast_PDB
96.33
50%
-100
- C4 -
4CZE
1
?
A:
[3-325]
---
S
N
D
I
A
I
D
L
G
T
--
A
N
T
L
I
Y
Q
K
G
K
-
G
---
I
---------
V
--------
L
---------
N
------
E
------
P
S
V
V
A
L
R
N
V
-
G
------
G
RK
V
V
--
H
---
A
V
G
I
----------
E
A
K
Q
M
L
G
R
T
P
G
--------------------------------------
H
M
E
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
F
E
V
A
---------------------
E
E
M
I
K
Y
F
I
R
K
V
H
N
R
K
-
G
-
F
V
N
P
--
K
V
I
V
C
V
P
S
G
A
T
A
V
E
R
R
A
I
N
D
S
C
-
L
N
A
-
G
A
R
R
V
G
L
I
D
E
P
M
A
A
A
I
--
G
A
G
L
P
I
-
H
-------
E
P
T
G
S
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
L
-----
S
L
S
-
G
---
I
--
V
--
Y
-----
S
--
R
S
V
----
R
V
-------
G
G
D
K
M
D
E
A
I
I
S
Y
M
R
R
H
H
N
---
L
L
-------------
I
-------------
G
-------------
E
T
T
A
E
R
I
K
K
E
I
G
TA
R
A
-
P
----
E
G
L
---
S
--------
I
D
------------
V
K
-
G
R
-----
D
L
M
Q
----
G
V
P
R
--
E
V
R
I
S
E
K
Q
A
---
A
D
A
L
A
E
P
------
V
-
G
Q
I
V
E
A
V
K
V
A
L
E
---
A
T
P
P
E
L
A
S
D
I
A
D
K
G
I
M
L
T
G
G
G
A
L
L
R
G
L
D
A
E
I
R
D
H
T
G
-
L
P
---------
V
--------------------
T
V
A
D
D
P
L
S
C
V
A
L
G
C
G
K
V
L
----------
5
PsiBlast_PDB
94.97
48%
-107
- C4 -
2WUS
-
?
A:
[6-331]
------
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
---------
V
--------
V
---------
N
------
E
------
P
S
V
I
A
I
D
S
T
-
T
------
G
--
E
I
--
L
---
K
V
G
L
----------
E
A
K
N
M
I
G
K
T
P
A
--------------------------------------
T
I
K
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
Y
T
V
A
---------------------
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
M
N
-
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
-
L
E
A
-
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
--
G
S
N
L
N
V
-
E
-------
E
P
S
G
N
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
-----
S
L
G
-
S
---
I
--
V
--
T
-----
W
--
E
S
I
----
R
I
-------
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
---
V
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
-
S
K
E
-
N
D
E
L
---
E
--------
T
T
------------
V
S
-
G
I
-----
D
L
S
T
----
G
L
P
R
--
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
---
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
---------
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
-
N
I
L
K
K
-
3
PsiBlast_PDB
94.32
48%
-99
- C4 -
1JCF
-
?
A:
[6-331]
------
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
---------
V
--------
V
---------
N
------
E
------
P
S
V
I
A
I
D
S
T
-
T
------
G
--
E
I
--
L
---
K
V
G
L
----------
E
A
K
N
M
I
G
K
T
P
A
--------------------------------------
T
I
K
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
Y
T
V
A
---------------------
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
M
N
-
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
-
L
E
A
-
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
--
G
S
N
L
N
V
-
E
-------
E
P
S
G
N
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
-----
S
L
G
-
S
---
I
--
V
--
T
-----
W
--
E
S
I
----
R
I
-------
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
---
V
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
-
S
K
E
-
N
D
E
L
---
E
--------
T
T
------------
V
S
-
G
I
-----
D
L
S
T
----
G
L
P
R
--
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
---
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
---------
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
-
N
I
L
K
K
-
4
PsiBlast_PDB
92.82
48%
-98
- C4 -
1JCG
2
?
A:
[6-331]
------
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
---------
V
--------
V
---------
N
------
E
------
P
S
V
I
A
I
D
S
T
-
T
------
G
--
E
I
--
L
---
K
V
G
L
----------
E
A
K
N
M
I
G
K
T
P
A
--------------------------------------
T
I
K
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
Y
T
V
A
---------------------
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
M
N
-
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
-
L
E
A
-
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
--
G
S
N
L
N
V
-
E
-------
E
P
S
G
N
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
-----
S
L
G
-
S
---
I
--
V
--
T
-----
W
--
E
S
I
----
R
I
-------
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
---
V
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
-
S
K
E
-
N
D
E
L
---
E
--------
T
T
------------
V
S
-
G
I
-----
D
L
S
T
----
G
L
P
R
--
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
---
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
---------
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
-
N
I
L
K
K
-
7
PsiBlast_PDB
75.56
25%
-86
- C4 -
2V7Y
2
DNAK_GEOKA
A:
[5-343]
------
I
G
I
D
L
G
T
--
T
N
S
C
V
A
V
L
E
G
-
G
E
V
K
V
---------
I
--------
P
---------
N
PEGNRT
T
------
P
S
V
V
A
F
K
N
G
-
E
------
R
--
L
V
--------
G
E
----------
V
A
K
R
Q
A
I
T
N
P
N
--------------------------------------
T
I
I
S
I
-----------------------------------------
K
-------------------------------
R
H
-------------
M
G
T
D
Y
K
V
E
I
EG
K
Q
Y
T
P
Q
E
I
----------
S
A
I
I
L
Q
Y
L
K
S
Y
-
A
E
D
-
Y
-
L
G
E
P
VT
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
R
I
A
-
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
--
A
Y
G
L
D
K
-
E
-------
E
D
Q
T
I
---
L
V
Y
-
D
L
G
G
G
T
F
D
V
S
I
L
-----
E
L
G
D
G
---
V
--
F
--
E
-----
V
--
K
A
T
A
G
D
N
H
L
-------
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
---
Q
E
-------------
H
-------------
G
IDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
---------
G
V
T
Q
---
T
QISLPFIS
A
N
------------
E
N
-
G
P
--------------
L
H
L
--
E
M
T
L
T
R
A
K
F
---
E
E
L
S
A
H
L
------
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
-----
I
D
K
-
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
---------
P
--------------------
H
K
G
V
N
P
D
E
V
V
A
I
G
---------------
9
PsiBlast_PDB
74.98
23%
-85
- C4 -
3GL1
6
HSP75_YEAST
A:
[13-378]
------
I
G
I
D
L
G
T
T
Y
S
C
V
A
T
Y
E
S
S
V
-
E
---
I
---------
I
--------
A
---------
N
------
E
QGNR
V
T
P
S
F
V
A
F
T
P
E
-
E
------
R
--
L
I
G
D
A
---
A
K
N
Q
A
ALNPRNTVF
D
A
K
R
L
I
G
R
R
F
D
--------------------------------------
D
E
S
V
Q
--------------------
K
D
-
M
-----------------
K
-------------------------------
T
W
-------------
P
F
K
V
I
D
V
D
G
N
P
V
I
E
V
Q
Y
LE
E
T
K
T
F
S
P
Q
E
I
S
A
M
V
L
T
K
M
K
E
I
-
A
E
A
-
K
-
I
G
K
K
VE
K
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
A
I
S
-
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
--
A
Y
G
L
G
A
-
G
-------
K
S
E
K
E
R
H
V
L
I
F
-
D
L
G
G
G
T
F
D
V
S
L
L
-----
H
I
A
-
G
GVY
T
--
V
--
K
-----
S
--
T
S
G
----
N
T
HL-----
G
G
Q
D
F
D
T
N
L
L
E
H
F
K
A
E
F
K
---
K
K
-------------
T
-------------
G
LDISDD
A
R
A
L
R
R
L
R
T
A
A
E
R
A
K
R
T
L
S
---------
S
V
T
Q
---
T
--------
T
-------------
V
E
-
V
D
-----
S
L
F
D
----
G
E
D
F
--
E
S
S
L
T
R
A
R
F
---
E
D
L
N
A
A
L
------
F
-
K
S
T
L
E
P
V
E
Q
V
L
K
-----
D
A
K
I
S
K
S
Q
I
D
E
-
V
V
L
V
G
G
S
T
R
I
P
K
V
Q
K
L
L
S
D
F
F
D
G
K
Q
---------
L
--------------------
E
K
S
I
N
P
D
E
A
V
A
Y
G
---------------
8
PsiBlast_PDB
73.88
25%
-89
- C4 -
4ANI
-
DNAK_GEOKA
C:
[5-343]
------
I
G
I
D
L
G
T
--
T
N
S
C
V
A
V
L
E
G
-
G
E
V
K
V
---------
I
--------
P
---------
N
PEGNR
T
T
------
P
S
V
V
A
F
K
N
G
-
E
------
R
--
L
V
--------
G
E
----------
V
A
K
R
Q
A
I
T
N
P
N
--------------------------------------
T
I
I
S
I
-----------------------------------------
K
-------------------------------
R
H
-------------
M
G
T
D
Y
K
V
E
I
EG
K
Q
Y
T
P
Q
E
I
----------
S
A
I
I
L
Q
Y
L
K
S
Y
-
A
E
D
-
Y
-
L
G
E
P
VT
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
R
I
A
-
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
--
A
Y
G
L
D
K
-
E
-------
E
D
Q
T
I
---
L
V
Y
-
D
L
G
G
G
T
F
D
V
S
I
L
-----
E
L
G
D
G
---
V
--
F
--
E
-----
V
--
K
A
T
A
G
D
N
H
L
-------
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
---
Q
E
-------------
H
-------------
G
IDLSKD
K
M
A
L
Q
R
L
K
D
A
A
E
K
A
K
K
E
L
S
---------
G
V
T
Q
---
T
Q
I
S
L
P
FIS
A
N
------------
E
N
-
G
P
--------------
L
H
L
--
E
M
T
L
T
R
A
K
F
---
E
E
L
S
A
H
L
------
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
D
A
G
L
T
P
A
D
-----
I
D
K
-
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
---------
P
--------------------
H
K
G
V
N
P
D
E
V
V
A
I
G
---------------
57
Fugue
73.22
25%
-98
- C4 -
1DKG
-
DNAK_ECOLI
D:
[3-383]
----
K
I
I
G
I
D
L
G
T
--
T
N
S
C
V
A
I
M
D
G
-
T
---
T
---------
P
--------
R
VLENAEGDR
T
------
T
------
P
S
I
I
A
Y
T
Q
D
----------------GET
L
V
G
Q
----------
P
A
K
R
Q
A
V
T
N
P
Q
NTLFAIKRLIGRRFQDEEVQRDVSIMPFKIIAADNGDA
W
V
E
V
----------------------
K
-
G
--------------------------------------------------
Q
-------------
K
M
A
P
P
Q
I
S
---------------------
A
E
V
L
K
K
M
K
K
T
A
E
D
Y
L
-
G
-
E
P
V
T
--
E
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
R
I
-A
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
AY
G
L
D
K
---
T
-------
G
N
R
T
I
---
A
V
Y
-
D
L
G
G
G
T
F
D
I
S
I
I
-----
E
I
D
-
E
---
K
--
T
--
F
-----
E
--
V
L
A
------TNGDTHL
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
---
K
D
-------------
Q
-------------
G
IDLRNDPLAMQRL
K
E
A
A
E
K
A
K
I
E
L
S
--
S
------------------------AQQTD-------
V
N
-
L
P
-----
Y
I
T
A
DATG
P
K
H
M
--
N
I
K
V
T
R
A
K
L
---
E
S
L
V
E
D
L
------
V
N-
R
S
I
E
L
L
K
V
A
L
Q
---
D
A
G
--
L
S
V
S
D
I
D
-
D
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
-
K
E
---------
P
--------------------
R
K
D
V
N
P
D
E
A
V
A
I
G
A
A
V
Q
G
G
V
L
T------
39
HHSearch
72.61
25%
-77
* C4 *
2V7Y
2
DNAK_GEOKA
A:
[1-351]
--
M
S
K
I
I
G
I
D
L
G
T
--
T
N
S
C
V
A
V
L
E
G
-
G
E
--
V
---------
K
V
I
P
N
PEGN
R
---------
T
------
T
------
P
S
V
V
A
F
K
N
------------
G
E
--
R
---
L
V
G
E
----------
V
A
K
R
Q
A
I
T
N
P
N
--------------------------------------
T
I
I
S
I
--------------------
K
R
H
M
GTD
Y
K
V
E
I
---------
E
-------------------------------
G
K
-------------
Q
Y
T
P
Q
E
I
S
---------------------
A
I
I
L
Q
Y
L
K
S
Y
A
-
E
D
Y
-
L
G
E
P
V
T
--
R
A
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
R
I
A
-
G
L
E
V
E
R
I
I
N
E
P
T
A
A
A
L
--
A
Y
G
L
D
K
-
E
-------
E
D
Q
T
I
---
L
V
Y
-
D
L
G
G
G
T
F
D
V
S
I
L
-----
E
L
G
-
D
---
G
--
V
--
F
E
V
K
A
T
A
--
G
D
N
----
H
L
-------
G
G
D
D
F
D
Q
V
I
I
D
Y
L
V
N
Q
F
K
---
Q
E
-------------
H
GIDLSKD
K
M
A
L
Q
R
L
-------------
K
D
A
A
E
K
A
K
K
E
L
S
--
G
V
-
T
-----
Q
T
---
Q
--------
I
S
------------
L
P
-
F
I
SA---
N
E
N
G
----
P
L
H
L
--
E
M
T
L
T
R
A
K
F
---
E
E
L
S
A
H
L
------
V
-
E
R
T
M
G
P
V
R
Q
A
L
Q
---
D
A
G
L
T
-
P
A
D
I
--
D
K
V
I
L
V
G
G
S
T
R
I
P
A
V
Q
E
A
I
K
R
E
L
G
-
K
E
---------
P
--------------------
H
K
G
V
N
P
D
E
V
V
A
I
G
A
A
I
Q
G
G
V
I
-------
36
HHSearch
69.52
19%
-79
- C4 -
3D2F
4
?
A:
[2-390]
---
S
T
P
F
G
L
D
L
G
N
--
N
N
S
V
L
A
V
A
R
N
-
R
---
G
I
D
I
V
V
N
EVS
N
--------
R
---------
S
------
T
------
P
S
V
V
G
F
G
P
------------
K
N
--
R
---
Y
L
G
E
----------
T
G
K
N
K
Q
T
S
N
I
K
--------------------------------------
N
T
V
A
N
LKRIIGLDYHHPD
F
E
Q
E
S
K
H
F
T
-
S
-----------------
K
L
V
E
L
D--------------------------
D
K
K
T
G
A
E
V
R
F
AG
E
K
H
V
F
S
A
T
Q
L
A
---------------------
A
M
F
I
D
K
V
K
D
T
V
-
K
Q
D
-
T
K
A
N
I
T
--
D
V
C
I
A
V
P
P
W
Y
T
E
E
Q
R
Y
N
I
A
D
A
A
-
R
I
A
-
G
L
N
P
V
R
I
V
N
D
V
T
A
A
G
V
--
S
Y
G
I
F
K
-
T
DLPEGEE
K
P
R
I
V
---
A
F
V
-
D
I
G
H
S
S
Y
T
C
S
I
M
-----
A
F
K
-
K
G
Q
-
L
K
V
L
G
-
T
-----
A
--
C
D
K
----
H
F
-------
G
G
R
D
F
D
L
A
I
T
E
H
F
A
D
E
F
K
---
T
K
YKIDIREN
P
K
A
Y
N
R
-------------
I
-------------
L
T
A
A
E
K
L
K
K
V
L
S
--
A
N
-
T
-----
N
A
---
P
--------
F
S
------------
V
E
--------
S
V
M
N
----
D
V
D
V
--
S
S
Q
L
S
R
E
E
L
---
E
E
L
V
K
P
L
------
L
-
E
R
V
T
E
P
V
T
K
A
L
A
---
Q
A
K
L
S
A
-
E
E
V
--
D
F
V
E
I
I
G
G
T
T
R
I
P
T
L
K
Q
S
I
S
E
A
F
G
-
K
P
---------
L
--------------------
S
T
T
L
N
Q
D
E
A
I
A
K
G
A
A
F
I
C
A
I
H
-
S
-----
41
HHSearch
69.34
23%
-81
- C4 -
3I33
3
HSP72_HUMAN
A:
[23-401]
---
M
P
A
I
G
I
D
L
G
T
--
T
Y
S
C
V
G
V
F
Q
H
-
G
---
K
V
E
I
I
A
N
DQG
N
--------
R
---------
T
------
T
------
P
S
Y
V
A
F
T
D
------------
T
E
--
R
---
L
I
G
D
----------
A
A
K
N
Q
V
A
M
N
P
T
--------------------------------------
N
T
I
F
D
AKRLIG--------------
R
K
-
F
-----------------
E
D
A
T
V
Q
S
D
M
K
H
WP
F
R
V
V
S
E
GG
K
P
K
V
Q
V
E
Y
KGE
T
K
-------------
T
F
F
P
E
E
I
S
---------------------
S
M
V
L
T
K
M
K
E
I
A
-
E
A
Y
-
L
G
G
K
V
H
--
S
A
V
I
T
V
P
A
Y
F
N
D
S
Q
R
Q
A
T
K
D
A
G
-
T
I
T
-
G
L
N
V
L
R
I
I
N
E
P
T
A
A
A
I
--
A
Y
G
L
D
K
-
K
GCAG---
G
E
K
N
V
---
L
I
F
-
D
L
G
G
G
T
F
D
V
S
I
L
-----
T
I
E
-
D
GI-
F
--
E
VK
S
T
----
A
--
G
D
T
----
H
L
-------
G
G
E
D
F
D
N
R
M
V
S
H
L
A
E
E
F
K
---
R
K
HKKDIGPN
K
R
A
V
R
R
-------------
L
-------------
R
T
A
C
E
R
A
K
R
T
L
S
--
S
S
-
T
-----
Q
A
---
S
--------
I
E
------------
I
D
--------
S
L
Y
E
----
G
V
D
F
--
Y
T
S
I
T
R
A
R
F
---
E
E
L
N
A
D
L
------
F
-
R
G
T
L
E
P
V
E
K
A
L
R
---
D
A
K
L
D
K
-
G
Q
--
I
Q
E
I
V
L
V
G
G
S
T
R
I
P
K
I
Q
K
L
L
Q
D
F
F
N
G
K
E
---------
L
--------------------
N
K
S
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
A
I
L
-------
40
HHSearch
66.59
23%
-84
- C4 -
3QFU
3
GRP78_YEAST
A:
[16-393]
-
N
Y
G
T
V
I
G
I
D
L
G
T
--
T
Y
S
C
V
A
V
M
K
N
-
G
---
K
T
E
I
L
A
N
EQG
N
--------
R
---------
I
------
T
------
P
S
Y
V
A
F
T
D
------------
D
E
--
R
---
L
I
G
D
----------
A
A
K
N
Q
V
A
A
N
P
Q
--------------------------------------
N
T
I
F
D
IKRLIGLKYND
R
S
V
Q
K
D
I
K
H
L
P
-
F
N
V
V
N
K
DG
K
P
A
V
E
V
S
V
KG
E
-------------------------------
K
K
-------------
V
F
T
P
E
E
I
S
---------------------
G
M
I
L
G
K
M
K
Q
I
A
-
E
D
Y
-
L
G
T
K
V
T
--
H
A
V
V
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
T
I
A
-
G
L
N
V
L
R
I
V
N
E
P
T
A
A
A
I
--
A
Y
G
L
D
K
S
D
-------
K
E
H
Q
I
---
I
V
Y
-
D
L
G
G
G
T
F
D
V
S
L
L
-----
S
I
E
-
N
---
G
--
V
--
F
EVQ
A
T
S
--
G
D
T
----
H
L
-------
G
G
E
D
F
D
Y
K
I
V
R
Q
L
I
K
A
F
K
---
K
K
-------------
H
GIDVSDN
N
K
A
L
A
K
L
-------------
K
R
E
A
E
K
A
K
R
A
L
S
--
S
Q
-
M
-----
S
T
---
R
--------
I
E
------------
I
D
--------
S
F
V
D
----
G
I
D
L
--
S
E
T
L
T
R
A
K
F
---
E
E
L
N
L
D
L
------
F
-
K
K
T
L
K
P
V
E
K
V
L
Q
---
D
S
G
L
E
K
K
--
D
V
-
D
D
I
V
L
V
G
G
S
T
R
I
P
K
V
Q
Q
L
L
E
S
Y
F
D
G
K
K
---------
A
--------------------
S
K
G
I
N
P
D
E
A
V
A
Y
G
A
A
V
Q
A
G
V
L
-------
38
HHSearch
65.50
18%
-89
- C4 -
1K8K
-
ARP3_BOVIN
A:
[4-388]
--
R
L
P
A
C
V
V
D
C
G
T
--
G
Y
T
K
L
G
Y
A
G
N
T
E
---
P
---------
Q
--------
F
---------
I
------
I
------
P
S
C
I
A
I
K
E
---VMKGVD
D
--
L
D
--
F
---
F
I
G
D
----------
E
A
I
E
K
-----
P
--------------------------------------
T
Y
A
T
K
--------------------
W
P
-
I
-----------------
R
-------------------------------
H
G
-------------
I
V
E
D
W
D
L
M
---------------------
E
R
F
M
E
Q
V
I
F
K
Y
-
L
R
A
-
E
-
P
E
D
H
--
Y
F
L
L
T
E
P
P
L
N
T
P
E
N
R
E
Y
T
A
E
I
M
F
E
S
F
-
N
V
P
G
L
Y
I
A
V
Q
A
V
L
A
L
A
--
A
S
W
T
S
R
-
Q
VGE----
R
T
L
T
G
---
T
V
I
-
D
S
G
D
G
V
T
H
V
I
P
V
-----
A
E
G
-
Y
---
V
--
I
--
G
-----
S
C
I
K
H
I
----
P
I
-------
A
G
R
D
I
T
Y
F
I
Q
Q
L
L
R
D
R
E
V
GIP
P
E
-------------
Q
-------------
S
-------------
L
E
T
A
K
A
V
K
E
R
Y
S
--
Y
V
C
P
D
L
-
V
--
K
---
E
--------
F
N
K
Y
D
T
DGSKW
I
K
Q
Y
T
-
G
I
-----
N
A
I
S
----
K
K
E
F
--
S
I
D
V
G
Y
E
R
F
LGP
E
I
F
F
H
P
E
FANPDF
T
-
Q
P
I
S
E
V
V
D
E
V
I
Q
---
N
C
P
I
D
V
R
R
P
L
Y
K
N
-
I
V
L
S
G
G
S
T
M
F
R
D
F
G
R
R
L
Q
R
D
L
K
-
R
T
---------
V
D
A
R
L
K
L
S
E
E
L
SKPK
P
I
D
V
Q
V
I
T
H
H
M
Q
R
Y
A
V
W
F
G
G
S
M
L
A
S
T
P
-------
10
PsiBlast_PDB
64.96
26%
-91
- C4 -
1DKG
-
DNAK_ECOLI
D:
[139-374]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
T
V
P
A
Y
F
N
D
A
Q
R
Q
A
T
K
D
A
G
-
R
I
A
-
G
L
E
V
K
R
I
I
N
E
P
T
A
A
A
L
--
A
Y
G
L
D
K
---------
T
G
N
R
T
---
I
A
V
Y
D
L
G
G
G
T
F
D
I
S
I
I
EIDEK
T
F
E
-
V
---
L
--
A
--
T
-----
N
--
G
D
T
----
H
L
-------
G
G
E
D
F
D
S
R
L
I
N
Y
L
V
E
E
F
K
---
K
D
-------------
Q
-------------
G
IDLRNDPLAMQRL
K
E
A
A
E
K
A
K
I
E
L
S
--
S
A
-
Q
Q
T
-
D
V
N
L
PYI
T
--------
A
D
------------
A
T
-
G
----------------
P
K
HM
N
I
K
V
T
R
A
K
L
---
E
S
L
V
E
D
L
------
V
-
N
R
S
I
E
L
L
K
V
A
L
Q
---
D
A
G
L
S
V
S
-
D
I
D
D
--
V
I
L
V
G
G
Q
T
R
M
P
M
V
Q
K
K
V
A
E
F
F
G
-
K
E
---------
P
--------------------
R
K
D
V
N
P
D
E
A
V
A
I
G
---------------
34
HHSearch
63.36
48%
-28
- C4 -
1JCE
-
?
A:
[4-331]
----
K
D
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
---------
V
--------
V
---------
N
------
E
------
P
S
V
I
A
I
D
S
T
-
T
------
G
--
E
I
--
L
---
K
V
G
L
----------
E
A
K
N
M
I
G
K
T
P
A
--------------------------------------
T
I
K
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
Y
T
V
A
---------------------
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
-
M
N
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
-
L
E
A
-
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
--
G
S
N
L
N
V
-
E
-------
E
P
S
G
N
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
-----
S
L
G
-
S
---
I
--
V
--
T
-----
W
--
E
S
I
----
R
I
-------
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
---
V
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
--
N
V
F
P
S
K
E
N
D
E
L
---
E
--------
T
T
------------
V
S
-
G
I
-----
D
L
S
T
----
G
L
P
R
--
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
---
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
---------
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
-
N
I
L
K
K
-
35
HHSearch
62.62
18%
-90
- C4 -
3DWL
1
ARP3_SCHPO
A:
[3-397]
-
S
F
N
V
P
I
I
M
D
N
G
T
--
G
Y
S
K
L
G
Y
A
G
N
-
D
A--
P
---------
S
--------
Y
---------
V
------
F
------
P
T
V
I
A
T
R
--T
E
------
D
--
L
D
--
F
---
F
I
G
N
----------
D
A
L
K
K
---
A
S
A
--------------------------------------
G
Y
S
L
D
--------------------
Y
P
-
I
-----------------
R
-------------------------------
H
G
-------------
Q
I
E
N
W
D
H
M
---------------------
E
R
F
W
Q
Q
S
L
F
K
Y
-
L
R
C
-
E
-
P
E
D
H
--
Y
F
L
L
T
E
P
P
L
N
P
P
E
N
R
E
N
T
A
E
I
M
F
E
S
F
-
N
C
A
G
L
Y
I
A
V
Q
A
V
L
A
L
A
--
A
S
W
T
S
S
-
K
VTD----
R
S
L
T
G
---
T
V
V
-
D
S
G
D
G
V
T
H
I
I
P
V
-----
A
E
G
-
Y
---
V
--
I
--
G
-----
S
SI
K
T
M
----
P
L
-------
A
G
R
D
V
T
Y
F
V
Q
S
L
L
R
--------------------------------------------------
L
K
T
A
E
R
I
K
E
E
C
C
--
Y
V
-
C
P
D
-
I
-
V
K
---
E
--------
F
S
R
-----------
F
D
R--LKYAS---------------
I
D
V
G
F
E
R
F
LAP
E
I
F
F
N
P
E
IASSDF
L
-
T
P
L
P
E
L
V
D
N
V
V
Q
---
S
S
P
I
D
V
R
K
G
L
Y
K
N
-
I
V
L
S
G
G
S
T
L
F
K
N
F
G
N
R
L
Q
R
D
L
K
-
R
I
V
D
E
RG
V
D
V
N
V
--------------------
I
S
H
K
R
Q
R
N
A
V
W
F
G
G
S
L
L
A
Q
T
P
-------
6
PsiBlast_PDB
62.32
47%
-29
- C4 -
1JCE
-
?
A:
[6-331]
------
I
G
I
D
L
G
T
--
A
N
T
L
V
F
L
R
G
K
-
G
---
I
---------
V
--------
V
---------
N
------
E
------
P
S
V
I
A
I
D
S
T
-
T
------
G
--
E
I
--
L
---
K
V
G
L
----------
E
A
K
N
M
I
G
K
T
P
A
--------------------------------------
T
I
K
A
I
--------------------
R
P
-
M
-----------------
R
-------------------------------
D
G
-------------
V
I
A
D
Y
T
V
A
---------------------
L
V
M
L
R
Y
F
I
N
K
A
-
K
G
G
M
N
-
L
F
K
P
--
R
V
V
I
G
V
P
I
G
I
T
D
V
E
R
R
A
I
L
D
A
G
-
L
E
A
-
G
A
S
K
V
F
L
I
E
E
P
M
A
A
A
I
--
G
S
N
L
N
V
-
E
-------
E
P
S
G
N
---
M
V
V
-
D
I
G
G
G
T
T
E
V
A
V
I
-----
S
L
G
-
S
---
I
--
V
--
T
-----
W
--
E
S
I
----
R
I
-------
A
G
D
E
M
D
E
A
I
V
Q
Y
V
R
E
T
Y
R
---
V
A
-------------
I
-------------
G
-------------
E
R
T
A
E
R
V
K
I
E
I
G
NV
F
P
-
S
K
E
-
N
D
E
L
---
E
--------
T
T
------------
V
S
-
G
I
-----
D
L
S
T
----
G
L
P
R
--
K
L
T
L
K
G
G
E
V
---
R
E
A
L
R
S
V
------
V
-
V
A
I
V
E
S
V
R
T
T
L
E
---
K
T
P
P
E
L
V
S
D
I
I
E
R
G
I
F
L
T
G
G
G
S
L
L
R
G
L
D
T
L
L
Q
K
E
T
G
-
I
S
---------
V
--------------------
I
R
S
E
E
P
L
T
A
V
A
K
G
A
G
M
V
L
D
K
V
-
N
I
L
K
K
-