@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1875: (2016-03-29 )
MKQLKVENLTKTYGEKSLFENISLTITEGERIGLIGVNGTGKSTLLQIISGSESGDKGTVTKAKDYTIGYLAQDPAFNEEDTVLAAVFDGDTAALRAMRKYEEVLLAMSLDAENTKLHDAYTAASQEMDASAAWDMNTEAKTILERLGITDLTAKISALSGGQRKRVGLAQVLIETPDLLILDEPTNHLDFQSIRWLEEYLNRFKGAVLLVTHDRYFLDRVTNHMVELDRGSAYRYVGNYEKFMESKAIRMENEVRESEKNKNLYRKELAWMRRGPQGRATKQNARQDRFHDLEKKVKIKTDDSELAIDFVTSRLGKDVFELKNLEKRFDEKQVLQDFSLIIQPGERLGITGNNGTGKSTLLNMLAGKLAPDAGEVVTGQTVQIGYYTQQNEEMDPDMRMIAYLQEAGEQVTTSGGEVISVSAMLERFLFPPNSHGKKIGSLSGGEKRRLFLLRILMERPNVLLLDEPTNDLDTQTLTVLEDYLESFNGTVITVSHDRYFLDKVVNKLLVFRAIGEVEIFYGEYSDYLKELEAKGKPAKSMKKMANTSVEKSSPEKKEKVKLTYQEQLEWDGIEDAISKLEKDIESLNETLEQTGADFTKAAEISGFITAKETELEQMMERWEFLSQYAE
Atome Classification :
(23 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........--------10....-------.-.---..20.....-...30........40........50......--..60----...--------------.-..--..70....-..--..--80.-..--.....90........100..-.-....110.......120.......130.......140.......150-....-....160.......170.......180.......190-------.......200..----..---...210.......220.--.....-.230.......240.......250.......260.......270.......280....----..---.290.......300.......310.--......320.......330.--........340.......350.......360.......370....-...380--------.------------.......390-------..-..--...---.400....------------------------------------------------------------------..----.-------410---------------.---------.--......420......----.430----..-.....440........450-........460.......470.----.-.----.-...---480.....----..-490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKQL
K
V
E
N
L
--------
T
K
T
YG
E
-------
K
-
S
---
L
FEN
I
S
L
T
I
-TEG
E
R
I
G
L
I
GVNGT
G
K
S
T
L
L
Q
I
ISGSESGDK--G
T
V
T
----KAK--------------
D
-
Y
T
--
I
G
Y
LAQDP-AF--NE--ED
T
-
V
L
--
A
A
V
FDG
D
T
A
A
L
R
A
M
R
K
Y
E
E
V
-
L
-
L
A
M
SLDAEN
T
K
L
H
D
A
Y
TA
A
S
QEMDASAAWDMN
T
E
A
K
T
I
L
E
R
LGI
T
D
--
L
T
A
K
-
I
S
ALSGGQRKRV
G
L
A
Q
V
L
IETP
D
L
L
I
LDEPTNHL
D
F
Q
-------
S
I
R
W
L
E
E
Y
L
N
RF----K
G
---
A
V
L
L
V
TH
D
R
Y
F
L
D
R
V
T
N
--
H
M
VEL-DRGS
A
Y
R
YVG
N
Y
E
K
F
M
E
S
K
A
I
R
M
E
N
E
V
R
E
S
E
KNK
N
L
Y
R
K
E
L
A
W
M
RRGPQGRATKQN
A
R
----
Q
D
---
R
F
H
D
L
E
K
K
V
K
IKTDD
S
E
L
A
I
D
F
V
T
S
--
R
L
G
K
D
V
F
E
L
K
N
L
E
K
R
F
D
--
E
--
K
Q
V
L
Q
D
F
S
L
I
IQPG
E
R
LGITGNNGT
G
K
S
T
L
L
N
M
L
A
G
KLAPDAGEV-VTG
Q
T
---------
V
------------
Q
I
G
Y
Y
TQQN--------EE-MD--
P
D
M
---
R
M
I
A
Y
L
Q
E
------------------------------------------------------------------AG----E-------QV----------------T---------T--SGG
E
V
I
S
V
S
A
M
L
E
R
F----LFPP----NS-HGKKIG-SLSGG
E
K
R
R
L
F
--
L
L
R
I
L
MERP
N
V
L
L
L
DEPTNDLD----
T
-
Q
----
T
-
L
T
V
---
L
E
D
Y
L
E
SF----N
G
-
T
V
I
T
VSH
D
R
Y
F
L
D
K
V
V
N
K
L
L
V
F
RAIG
E
V
E
I
F
YG
E
Y
S
D
Y
L
K
E
L
E
AKGK
P
A
K
S
M
K
K
M
ANTSVEKSSPEKK
E
K
V
K
L
T
Y
Q
E
QLEWD
G
I
E
D
A
I
S
K
L
E
K
D
I
E
S
L
N
E
T
L
E
QTGADFTKAAE
I
S
G
F
I
TA
K
E
T
E
L
E
Q
M
M
E
R
W
E
F
L
S
Q
YAE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.38
37%
-70
- C1 -
4FIN
13
ETTA_ECOLI
A:
[18-530]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
R
-
H
---
I
L
K
N
I
S
L
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
--
G
E
A
R
----
P
Q
P
--------------
D
-
I
K
--
I
G
Y
L
P
Q
E
P
-
Q
L
--
N
P
--
E
H
T
-
V
R
--
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
-
Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
-
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
-
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
----
L
A
---
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
--
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
-
T
L
G
E
T
---------
V
------------
K
L
A
S
V
D
Q
F
R
--------
D
S
-
M
D
---
N
S
---
K
T
V
W
E
E
V
S
------------------------------------------------------------------
G
G
----
L
-------
D
I
----------------
M
---------
K
--
I
G
N
T
E
M
P
S
R
A
Y
V
G
R
F
----
N
F
K
G
----
V
D
-
Q
G
K
R
V
G
-
E
L
S
G
G
E
R
G
R
L
H
--
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
----
I
-
E
----
T
-
L
R
A
---
L
E
N
A
L
L
E
F
----
P
G
-
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.22
37%
-59
- C1 -
3J5S
-
ETTA_ECOLI
D:
[24-536]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
R
-
H
---
I
L
K
N
I
S
L
S
F
-
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
I
E
--
G
E
A
R
----
P
Q
P
--------------
D
-
I
K
--
I
G
Y
L
P
Q
E
P
-
Q
L
--
N
P
--
E
H
T
-
V
R
--
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
-
Y
A
L
Y
A
D
P
D
A
D
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
I
Q
A
H
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
D
--
W
D
A
K
-
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
--
W
I
L
E
L
-
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
----
L
A
---
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
I
P
P
G
P
--
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
--
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
-
T
L
G
E
T
---------
V
------------
K
L
A
S
V
D
Q
F
R
--------
D
S
-
M
D
---
N
S
---
K
T
V
W
E
E
V
S
------------------------------------------------------------------
G
G
----
L
-------
D
I
----------------
M
---------
K
--
I
G
N
T
E
M
P
S
R
A
Y
V
G
R
F
----
N
F
K
G
----
V
D
-
Q
G
K
R
V
G
-
E
L
S
G
G
E
R
G
R
L
H
--
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
----
I
-
E
----
T
-
L
R
A
---
L
E
N
A
L
L
E
F
----
P
G
-
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
E
F
F
E
G
N
F
T
E
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
82.53
30%
-87
- C- -
2IW3
7
EF3A_YEAST
A:
[439-979]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
E
F
--------
S
L
A
Y
G
A
-------
K
-
I
---
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
--
D
--
G
F
P
T
-----
Q
E
--------------
E
-
C
R
--
T
V
Y
V
E
H
D
I
-
D
G
T-
H
S
--
D
T
S
-
V
L
--
D
F
V
F
E
S
G
V
--------------------------------------------
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
-
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
V
K
K
C
P
A
A
K
-----------
A
Y
E
-
E
L
S
N
---------------
T
------------
D
L
E
--
F
K
-
F
P
E
P
G
Y
L
E
---
G
V
K
--
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
--
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
-
Y
T
H
E
N
---------
C
------------
R
I
A
Y
I
K
Q
H
A
--------
F
A
H
I
E
SH
L
D
K
---
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
NIGM
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
R-
P
L
T
R
K
-
E
I
E
E
H
C
S
M
L
----
G
L
D
P
----
E
I
V
S
H
S
R
I
R
-
G
L
S
G
G
Q
K
V
K
L
V
--
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
----
R
-
D
----
S
-
L
G
A
---
L
S
K
A
L
K
E
F
----
E
G
-
G
V
I
I
I
T
H
S
A
E
F
T
K
N
L
T
E
E
V
W
A
V
K
-
D
G
R
M
T
P
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
64.44
21%
-60
- C1 -
3OZX
5
?
A:
[4-463]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
--------
I
H
R
Y
K
V
N------
G
-
F
---
K
L
F
G
L
P
T
-
P
-
K
N
N
T
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
L
A
G
E
I
I
P
N
F
--
G
D
P
N
----
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
-
K
E
--
I
Y
N
Y
F
K
E
L
-
Y
S
---
N
--
E
L
K
-
I
V
--
H
K
I
Q
Y
V
E
Y
-
A
S
----
K
F
--------
L
------------
K
G
T
V
N
E
I
---
L
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
N
L-
W
N
K
D
-
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
-------
E
R
M
N
M
A
K
A
I
R
E
L
L
K--
N
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
--
L
I
H
I
I
-
Y
-
G
E
S
S
V
Y
-
G
R
V
S
K
S
Y
A
A
R
V
G
I
-----------
N
N
F
L
K
G
Y
L
---
P
---
A
E
-
N
--
M
K
I
R
----
P
------
D
E
I
K
--
F
M
-
L
K
----------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
--
D
---
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
I
L
V
G
E
I
T
A
D
E
G
S
V
-
T
P
E
K
----------
Q
------------
I
L
S
Y
K
P
Q
R
I
--------
F
P
--
N
--
Y
D
G
---
T
V
Q
Q
Y
L
E
N
------------------------------------------------------------------
A
S
----
K
-------
D
A
--------------------------
L
--
S
T
S
S
W
-
F
F
E
E
V
T
K
R
L
----
N
L
H
R
-----
L
-
L
E
S
N
V
N
-
D
L
S
G
G
E
L
Q
K
L
Y
--
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
----
V
-
E
----
E
-
R
Y
I
---
V
A
K
A
I
K
R
V
T
R
E
R
K
A
-
V
T
F
I
I
D
H
D
L
S
I
H
D
Y
I
A
D
R
I
I
V
F
K
-
G
E
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Fugue
60.50
20%
-24
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
CP
F
D
A
I
Q
I
I
N
L
PT
N
L
E
A
H
V
T
H
R
Y
S
A
-------
N
-
S
---
F
K
L
H
R
L
P
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
----
D
P
P
--------------
E
-----
W
Q
E
I
I
K
Y
F
-
R
G
--
S
E
--
L
Q
N
-
Y
F
--
T
K
M
L
E
D
D
I
K
A
---------
I
-
I
-
K
P
Q
Y
V
D
N
I
P
R
A
I
K
G
P
V
Q
K
V
G
E
L
L
K
L
R
M
-
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
--
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
R
L
N
A
A
Q
I
I
R
S
L
----
L
A
P
T
K
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
--
F
V
C
I
I
Y
G
V
P
S
V
Y
G
V
V
T
L
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
---------------------
L
R
F
R
T
E
----
A
L
---
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
--
K
K
T
Q
G
D
F
V
L
N
V
E
E
G
E
F
-----------------
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
-
I
P
K
L
N
--------------------------
V
S
M
K
P
--------
Q
K
-
I
A
--
P
K
F
---
P
--
G
T
V
R
Q
------------------------------------------------------------------
L
F
----
F
-------
K
K
----------------
I
---------
R
--
G
Q
F
L
N
P
Q
F
Q
T
D
V
V
K
P
----
L
R
I
D
----
D
I
-
I
D
Q
E
V
Q
-
H
L
S
G
G
E
L
Q
R
V
A
--
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
----
S
-
E
Q
R
I
I
C
-
S
K
V
---
I
R
R
F
I
L
H
N
----
K
K
-
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
----------------------
E
G
I
P
S
K
N
A
H
A
R
A
P
E
S
L
L
T
G
C
N
R
F
L
K
N
L
N
V
T
F
R
----------------
R
D
P
N
S
F
R
P
R
I
N
K
L
D
S
Q
M
D
K
E
Q
K
S
S
G
--------------
N
Y
F
F
L
D
N
T
G
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
HHSearch
59.26
30%
-82
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-221]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
Q
L
Q
N
V
--------
T
K
A
W
G
E
-------
V
-
V
---
V
S
K
D
I
N
L
D
I
-
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
--
G
D
L
F
----
I
G
E
KRMNDTPPA-----
E
-
R
G
--
V
G
M
V
F
Q
S
Y
-
A
L
--
Y
P
--
H
L
S
-
V
A
--
E
N
M
S
F
G
L
K
L
A
G
-------------------------------------
A
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
H
L-
L
D
R
K
-
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
-------
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
--
K
I
V
V
L
-
D
A
G
R
V
A
Q
V
-
G
K
P
L
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
57.27
25%
-76
- C1 -
2IX3
6
EF3A_YEAST
A:
[445-744]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
-------
K
-
I
---
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
--
D
--
G
F
P
T
----
Q
E
E
--------------
C
-
R
T
--
V
-
Y
V
E
H
D
I
-
D
G
--
T
H
--
S
D
T
S
V
L
--
D
F
V
F
E
S
G
V
G
T
K
E
A
I
--------------------------------------------
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
-
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
----------------------------
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
----
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
---------------
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
GT
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
-
Y
T
H
E
N
---------
C
------------
R
I
A
Y
I
K
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
56.83
25%
-42
- C1 -
3BK7
2
?
A:
[95-545]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
--------
V
H
R
Y
G
V
-------
N
-
A
---
F
V
L
Y
R
L
P
I
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
----
D
S
W
--------------
D
-
N
V
--
I
R
-------
A
F
RG
N
E
--
L
Q
N
-
Y
F
--
E
R
L
K
N
G
E
---
I
R
P
V
V
K
P
Q
Y
V
D
L
-
L
P
K
A
V
K
G
K
V
R
E
L
----
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
----------
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
L
----
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
--------
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
--
N
G
I
N
E
F
L
-----------------
Q
G
Y
L
K
D
E
N
V
R
FRP
Y
E
I
---
R
F
T
K
L
S
E
R
V
D
V
---
E
R
E
T
L
V
E
Y
--
P
--
R
L
V
K
D
Y
G
S
F
K
-
L
E
V
E
P
G
--
E
------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
-
E
W
D
L
T
---------
V
------------
A
---
Y
K
P
Q
--------------------------
Y
I
K
A
------------------------------------------------------------------
E
Y
----
E
-------
G
T
----------------
V
---------
Y
--
E
L
L
S
K
I
D
S
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
LGII
D
L
-
Y
D
R
N
V
E
-
D
L
S
G
G
E
L
Q
R
V
A
--
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
----
V
E
Q
----
R
-
L
A
V
S
R
A
I
R
H
L
M
E
K
N
----
E
K
-
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
56.29
25%
-76
- C1 -
2IWH
8
EF3A_YEAST
A:
[445-744]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
-------
K
-
I
---
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
--
D
--
G
F
P
T
----
Q
E
E
--------------
C
-
R
T
--
V
-
Y
V
E
H
D
I
-
D
G
--
T
H
--
S
D
T
S
V
L
--
D
F
V
F
E
S
G
V
G
T
K
E
A
I
--------------------------------------------
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
-
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
----------------------------
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
----
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
---------------
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
GT
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
-
Y
T
H
E
N
---------
C
------------
R
I
A
Y
I
K
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
56.17
25%
-76
- C1 -
2IW3
6
EF3A_YEAST
A:
[445-744]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
G
A
-------
K
-
I
---
L
L
N
K
T
Q
L
R
L
-
K
R
A
R
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
I
A
N
G
Q
V
--
D
--
G
F
P
T
----
Q
E
E
--------------
C
-
R
T
--
V
-
Y
V
E
H
D
I
-
D
G
--
T
H
--
S
D
T
S
V
L
--
D
F
V
F
E
S
G
V
G
T
K
E
A
I
--------------------------------------------
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
-
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
V
A
W
L
V
N
Y
L
N
T
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
--
Y
I
I
N
Y
-
E
G
L
K
L
R
K
Y
K
G
N
F
T
E
F
----------------------------
V
K
K
C
P
A
A
K
A
Y
E
E
L
S
N
----
T
D
L
E
F
K
F
P
E
P
G
Y
L
E
G
V
K
T
K
Q
---------------
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
GT
S
--
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
V
L
T
G
E
L
L
P
T
S
G
E
V
-
Y
T
H
E
N
---------
C
------------
R
I
A
Y
I
K
Q
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
56.09
20%
-49
- C1 -
3J16
2
RLI1_YEAST
B:
[82-542]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
--------
T
H
R
Y
S
A
-------
N
S
F
---
K
L
H
R
L
P
-
T
P
-
R
P
G
Q
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
L
A
G
K
Q
K
P
N
L
--
G
R
F
D
----
D
P
P
--------------
E
W
Q
E
--
I
I
K
Y
F
R
G
S
-
E
L
--
Q
N
Y
F
T
K
M
-
L
E
--
D
D
I
K
A
I
I
K
P
--
Q
Y
---
V
D
N
I
-
P
-
R
A
I
---------
K
G
P
V
Q
K
V
G
E
L
L
K
-
L
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
N
V-
L
K
R
D
-
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
R
L
N
A
A
Q
I
I
R
S
L
L
A
P
-
T
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
--
F
V
C
I
I
-
Y
G
V
P
S
V
-
Y
-
G
V
V
T
L
P
A
S
V
R
E
-----------
G
I
N
I
F
L
D
G
H
I
P
------------
A
E
N
L
----
R
F
---
R
T
E
A
L
Q
--
F
R
-
I
A
D
-
A
T
E
D
L
---
Q
N
--
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
G
-----
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
L
L
A
G
A
L
K
P
D
E
G
Q
D
-
I
P
--
K
---------
L
------------
N
V
S
M
K
P
Q
K
I
--------
A
P
-
K
---
F
P
G
---
T
V
R
Q
L
F
F
K
------------------------------------------------------------------
K
I
----
R
-------
G
Q
----------------
F
---------
L
----
N
P
Q
-
F
Q
T
D
V
V
K
P
L
----
R
I
D
-----
D
I
-
I
D
Q
E
V
Q
-
H
L
S
G
G
E
L
Q
R
V
A
--
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
----
S
-
E
----
Q
-
R
I
I
---
C
S
K
V
I
R
R
F
I
L
H
N
K
K
-
T
A
F
I
V
E
H
D
F
I
M
A
T
Y
L
A
D
K
V
I
V
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
55.51
25%
-54
- C1 -
1YQT
4
?
A:
[25-475]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
--------
V
H
R
Y
G
V
-------
N
-
A
---
F
V
L
Y
R
L
P
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
G
D
N
----
D
S
W
--------------
D
-
G
V
--
I
R
-------
A
F
RG
N
E
--
L
Q
N
-
Y
F
--
E
K
L
K
N
G
E
---
I
R
P
V
V
K
P
Q
Y
V
D
L
-
I
P
K
A
V
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
----
E
N
V
L
E
R
----------
E
-
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
---------
E
G
K
--
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
--------
Y
G
E
P
G
V
Y
G
I
F
S
Q
P
K
G
T
R
--
N
G
I
N
E
-------------
F
L
R
----
G
Y
L
K
D
E
N
V
R
----------
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
S
F
R
-
L
E
V
E
P
G
--
E
------------
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
-
E
W
D
L
T
---------
V
------------
A
---
Y
K
P
Q
Y
--------
I
K
-
A
D
--
Y
E
G
---
T
V
Y
E
L
L
S
K
--------------------------------------------------------------------------------------------------------------------
I
D
A
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
LGII
D
L
-
Y
D
R
E
V
N
-
E
L
S
G
G
E
L
Q
R
V
A
--
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
----
V
E
Q
----
R
-
L
A
V
S
R
A
I
R
H
L
M
E
K
N
----
E
K
-
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
55.27
25%
-39
- C1 -
3J15
2
?
B:
[81-531]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
--------
V
H
R
Y
G
V
-------
N
-
A
---
F
V
L
Y
R
L
P
I
V
-
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
----
D
S
W
--------------
D
-
N
V
--
I
R
-------
A
F
RG
N
E
--
L
Q
N
-
Y
F
--
E
R
L
K
N
G
E
---
I
R
P
V
V
K
P
Q
Y
V
D
L
-
L
P
K
A
V
K
G
K
V
R
E
L
----
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
----------
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
L
----
A
N
E
G
K
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
--------
Y
G
E
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
--
N
G
I
N
E
F
L
-----------------
Q
G
Y
L
K
D
E
N
V
R
FRP
Y
E
I
---
R
F
T
K
L
S
E
R
V
D
V
---
E
R
E
T
L
V
E
Y
--
P
--
R
L
V
K
D
Y
G
S
F
K
-
L
E
V
E
P
G
--
E
------------
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
-
E
W
D
L
T
---------
V
------------
A
---
Y
K
P
Q
--------------------------
Y
I
K
A
------------------------------------------------------------------
E
Y
----
E
-------
G
T
----------------
V
---------
Y
--
E
L
L
S
K
I
D
S
S
K
L
N
S
N
F
Y
K
T
E
L
L
K
P
LGII
D
L
-
Y
D
R
N
V
E
-
D
L
S
G
G
E
L
Q
R
V
A
--
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
----
V
E
Q
----
R
-
L
A
V
S
R
A
I
R
H
L
M
E
K
N
----
E
K
-
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
55.15
23%
-52
- C1 -
1YQT
4
?
A:
[25-480]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
C
--------
V
H
R
Y
G
V
N------
A
-
F
---
V
L
Y
R
L
P
-
V
V
-
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
CG
D
N
D
S
----
W
D
G
--------------
V
-
I
R
A
F
R
G
N
E
L
Q
N
Y
F
E
K
--
L
K
--
N
G
E
-
I
R
--
P
V
V
K
P
Q
Y
V
D
L
I
P
------------
K
A
V
--------
K
G
K
V
------
I
E
L
L
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
N
V-
L
E
R
E
-
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
N
A
A
R
A
I
R
R
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
--
I
I
H
V
V
-
Y
G
E
P
-----
G
V
Y
G
I
F
S
Q
P
K
G
T
R
--------
N
G
I
N
E
F
L
R
G
---
Y
L
K
-----------
D
E
----
N
V
---
R
F
R
P
Y
E
--
I
K
-
F
T
K
-
T
G
E
R
V
----
E
--
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
--
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
I
-
E
W
D
L
-----------------------
T
V
A
Y
K
P
Q
Y
I
--------
K
A
-
D
---
Y
E
G
---
T
V
Y
E
L
L
S
K
------------------------------------------------------------------
I
D
----
A
-------
S
-----------------
K
---------
L
---
N
S
N
F
-
Y
K
T
E
L
L
K
P
L
----
G
I
I
D
-----
L
-
Y
D
R
E
V
N
-
E
L
S
G
G
E
L
Q
R
V
A
--
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
----
V
-
E
----
Q
-
R
L
A
---
V
S
R
A
I
R
H
L
M
E
K
N
E
K
-
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
-
G
E
P
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
55.09
35%
-83
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-199]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
H
I
G
H
L
S
K
S
F
Q
--
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
---------
I
FSKNTNLPVRER
R
L
G
Y
L
V
Q
E
G
---------
V
-
L
F
--
P
H
L
TVY
R
N
I
A
Y
G
L
G
------------------------------------------------------------------
N
G
----
K
-------
G
R
----------------
T
---------
A
--
Q
--
E
R
Q
R
I
E
A
M
L
E
L
T
----
G
I
-
S
----
E
L
-
A
G
R
Y
P
H
-
E
L
S
G
G
Q
Q
Q
R
A
A
--
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
-
Q
----
L
R
R
Q
I
---
R
E
D
M
I
A
A
L
RA--
N
G
K
S
A
V
F
V
S
H
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
54.97
35%
-82
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-204]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
H
I
G
H
L
S
K
S
F
Q
--
N
--
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
T
---------
I
FSKN
T
N
L
P
VRER
R
L
G
Y
L
V
Q
E
G
---------
V
-
L
F
--
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
------------------------------------------------------------------
N
G
----
K
-------
G
R
----------------
T
---------
A
--
Q
--
E
R
Q
R
I
E
A
M
L
E
L
T
----
G
I
-
S
----
E
L
-
A
G
R
Y
P
H
-
E
L
S
G
G
Q
Q
Q
R
A
A
--
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
-
Q
----
L
R
R
Q
I
---
R
E
D
M
I
A
A
L
R
A
--
N
G
K
S
A
V
F
V
S
H
D
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
53.65
23%
-52
- C1 -
3BK7
4
?
A:
[83-546]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
S
I
V
N
L
--------
P
E
Q
L
D
E
D
CVHRYG
V
-
N
---
A
F
V
L
Y
R
L
P
I
V
K
D
G
M
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
L
A
G
Q
L
I
P
N
L
--
C
E
D
N
----
D
S
W
--------------
D
--
N
--
V
I
R
A
F
R
G
N
-
E
L
--
Q
N
--
Y
F
E
-
R
L
K
N
G
E
I
R
P
V
V
K
------
P
Q
Y
V
D
L
-
L
-
P
K
A
--------
V
K
---
G
K
V
R
E
---
L
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V-
L
D
R
E
-
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
E
-
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
--
V
I
H
V
V
-
Y
G
E
-----
P
G
V
Y
G
I
F
S
K
P
K
G
T
R
N
--------
G
I
N
E
F
L
Q
G
Y
L
---
K
---
D
-----
E
N
V
R
----
F
R
---
P
-
Y
E
I
R
--
F
T
-
K
---
L
S
E
----
R
V
D
--
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
--
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
G
V
E
E
P
T
E
G
K
V
-
E
W
D
-----------
L
------------
T
V
A
Y
K
P
Q
Y
I
--------
K
A
-
E
---
Y
E
G
---
T
V
Y
E
L
L
S
K
------------------------------------------------------------------
I
D
----
S
-------
S
-----------------
K
---------
L
---
N
S
N
F
-
Y
K
T
E
L
L
K
P
L
----
G
I
I
D
-----
L
-
Y
D
R
N
V
E
-
D
L
S
G
G
E
L
Q
R
V
A
--
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
----
V
-
E
----
Q
-
R
L
A
---
V
S
R
A
I
R
H
L
M
E
K
N
E
K
-
T
A
L
V
V
E
H
D
V
L
M
I
D
Y
V
S
D
R
L
I
V
F
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
HHSearch
51.97
26%
-75
- C1 -
2IT1
-
?
A:
[2-221]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
I
K
L
E
N
I
V
K
K
F
G
--
N
--
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
-
Y
F
D
E
K
DVTELPPKD
R
------------
N
V
G
L
V
F
Q
N
W
--------
A
--
L
Y
--
P
H
M
---
T
V
Y
K
N
I
A
F
------------------------------------------------------------------
P
L
----
E
-------
L
R
----------------
K
---------
A
P
R
E
E
I
D
K
-
K
V
R
E
V
A
K
M
L
----
H
I
D
K
-----
L
-
L
N
R
Y
P
W
-
Q
L
S
G
G
Q
Q
Q
R
V
A
--
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
----
A
-
L
----
L
-
R
L
E
---
V
R
A
E
L
K
R
L
Q
K
E
L
G
I
-
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
-
E
G
E
I
L
Q
V
-
G
T
P
D
E
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
51.39
26%
-76
- C1 -
3TUI
1
METN_ECOLI
C:
[23-252]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
--------
T
K
V
F
H
Q
GTRT---
I
-
Q
---
A
L
N
N
V
S
L
H
V
-
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
--
G
S
V
L
----
V
D
G
QELTTLSESELTKA
R
-
R
Q
--
I
G
M
I
F
Q
H
F
-
N
L
--
L
S
--
S
R
T
-
V
F
--
G
N
V
A
L
P
L
E
L
D
-
N
------------------------------------
T
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
D
K-
H
D
S
Y
-
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-------
T
T
R
S
I
L
E
L
L
K
D
I
NRRL
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
--
C
V
A
V
I
-
S
N
G
E
L
I
E
Q
-
D
T
V
S
E
V
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Fugue
50.73
19%
-31
- C1 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
P
L
M
S
I
L
Q
G
K
V
S
Q
A
F
I
N
E
Q
I
V
I
N
N
N
G
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
V
M
N
V
V
W
S
Y
A
A
M
T
V
G
M
W
A
A
G
Q
I
T
V
T
C
Y
L
Y
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
QE
I
S
W
F
D
T
N
HSGT
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
GD
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
I
A
K
S
M
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
NG
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
S
F
G
A
M
Q
A
S
N
F
I
S
F
A
L
A
F
Y
I
G
V
G
W
V
H
D
GSLN
F
G
D
M
L
T
T
F
S
S
V
M
M
G
S
M
A
L
G
L
A
G
P
Q
L
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
V
LDRKPVIDSS
S
K
A
G
R
KDMKI
K
G
D
I
T
V
E
N
V
--------
H
F
T
Y
P
S
-------
R
-
P
DVP
I
L
R
G
M
N
L
R
V
-
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
L
K
--
G
K
I
T
I
DGV
D
V
R
--------------
D
-
I
N
--
L
E
F
L
R
K
N
------------------
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
---------
I
E
E
N
I
S
L
G
K
E
G
I
T
R
E
E
M
V
A
A
C
K
M
-
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
--------
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
-------
S
E
G
I
V
Q
Q
A
L
D
K
A
A
---
K
G
---
R
T
T
I
I
I
A
H
R
L
S
T
I
R
N
A
D
--
L
I
I
S
C
-
K
N
G
-
Q
V
V
E
V
G
D
H
R
A
L
M
----------------------------------------
A
Q
----
Q
G
---
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
G
---
E
--
R
I
G
K
D
--
A
L
S
R
L
K
Q
E
L
E
--
E
------------------------
N
N
A
Q
K
T
N
L
F
E
I
L
Y
H
A
R
P
H
A
L
S
L
F
-
I
G
M
S
T
---------
A
------------
T
I
G
G
F
I
Y
P
T
--------
Y
S
-
V
F
--
F
T
S
---
F
M
N
V
F
A
G
N
------------------------------------------------------------------
P
A
----
D
-------
F
L
----------------
S
---------
Q
--
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
----
G
I
C
S
----
F
L
-
M
T
F
F
M
G
-
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
Q
-
H
I
G
F
F
D
S
P
Q
N
A
-
S
----
G
-
K
----
I
-
S
T
R
---
L
A
T
D
V
P
N
L
----
R
T
-
A
I
-----
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
R
R
F
T
G
K
N
V
K
S
A
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
A
R
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
21
PsiBlast_CBE
43.82
31%
-57
- C1 -
4HLU
3
ECFA2_THEMA
B:
[21-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-
L
Y
D
G
E
---------
R
------------
K
K
G
Y
E
I
R
R
N
IGIAFQYP
E
D
-
Q
F
--
F
A
E
---
R
V
F
D
E
V
A
F
------------------------------------------------------------------
A
V
----
K
-------
N
F
----------------
Y
---------
P
--
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
----
G
L
D
F
----
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
--
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
REGK
T
-
D
----
L
-
L
R
I
---
V
E
K
W
-
K
T
L
----
G
K
-
T
V
I
L
I
S
H
D
---
I
E
T
V
I
N
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
42.33
31%
-55
- C1 -
4HLU
2
ECFA2_THEMA
A:
[21-207]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-
L
Y
D
G
E
---------
R
------------
K
K
G
Y
E
I
R
R
N
I
G
I
A
F
QYP
E
D
-
Q
F
--
F
A
E
---
R
V
F
D
E
V
A
F
------------------------------------------------------------------
A
V
----
K
-------
N
F
----------------
Y
---------
P
--
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
----
G
L
D
F
----
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
--
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
-
D
----
L
-
L
R
I
---
V
E
K
W
-
K
T
L
----
G
K
-
T
V
I
L
I
S
H
D
---
I
E
T
V
I
N
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
38.06
31%
-55
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[20-206]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--
K
K
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
-
L
Y
D
G
E
-----------------------
K
G
Y
E
I
R
R
N
I
G
I
A
F
QYP
E
D
-
Q
F
--
F
A
E
---
R
V
F
D
E
V
A
F
------------------------------------------------------------------
A
V
----
K
-------
N
F
----------------
Y
---------
P
--
D
R
D
P
V
P
L
V
K
K
A
M
E
F
V
----
G
L
D
F
----
D
S
-
F
K
D
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
--
I
A
S
V
I
V
H
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
-
D
----
L
-
L
R
I
---
V
E
K
W
-
K
T
L
----
G
K
-
T
V
I
L
I
S
H
D
---
I
E
T
V
I
N
H
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------