@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu01660: (2016-06-03 )
MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSLDEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQTVQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSIIGKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIASALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAFDDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEAVVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISLKIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPKKGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEADYIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPYDAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPGNTLYPLGYGLNIKTGRPL
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80........90......------..100.......110.----..-------.----.....120.......130-.-.-.-..-..140.......150-....-------...160.......170.......180.......190.......200.......210.---------.------.....220.......230.......240.......250.......260----.----......270.......280.......290.......300.......310........320.......--330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460...----..--------..----------------470.-......480....----...490--------------------........500-.........510.......520.......530.......--540.......550.......560.-.......570.-.......580..--.....590.......600....------...610.......620---------.-----------------------------......630.......640------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MR
P
V
F
P
L
I
L
S
A
V
L
F
L
S
C
F
FGARQTEASASKRAI
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
EGESS
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
YQFG
G
I
I
L
F
AENVK------TT
K
Q
T
V
Q
LT
D
D
Y
Q--K----AS-------P----KI
P
L
M
L
S
IDQEG
G
I
V
T
RL-G-E-G-TN-FPGN
M
A
L
G
A
A
R
S
R
I
N
-AYQT-------
G
S
I
I
G
K
E
L
S
A
LGINTDF
S
P
V
V
DINNNPDN
P
V
I
G
V
R
SFSS
N
R
E
L
T
S
RL
G
L
Y
T
MKGL
Q
R
---------
Q
------
D
I
A
S
A
L
K
HFPGHGDTDVDSHYGL
P
L
V
S
H
G
Q
E
R
L
R
EVELY
P
F
Q
K
A
I
DAG----A----
D
M
V
M
T
A
H
VQFPAFDDTTYKSKLDGS
D
I
L
VP
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
MG-FN
G
V
I
V
TDAL
N
M
K
A
I
A
D
HF--GQE
E
A
V
V
M
A
V
KAG
V
D
I
A
LMPA
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
KNGDI
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
KRGMYPARNSD
S
T
K
E
K
I
A
K
A
K
K
I
VG
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
KNEQHTLPFKPKKG
S
R
I
L
I
VAPY
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
RKKIKPVS
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
VKEA
D
Y
I
I
TG
S
Y
V
VKNDPVVNDGVIDDTISDSS
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
QHNK
P
F
V
L
M
S-L-RNPYDAA
N
F
-
E
-
E
A
K
A
L
I
A
V
YGFK--GYANG
R
Y
LQPNI
P
A
G
V
M
A
I
FGQ------AKPKGTLPVDIPSVTK---------P-----------------------------G
N
T
L
Y
PLG
Y
G
L
NIKTGRPL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
99.23
99%
-80
- C1 -
4GYK
1
NAGZ_BACSU
A:
[31-646]
--------------------------
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
98.89
99%
-81
- C1 -
4GYK
1
NAGZ_BACSU
B:
[38-646]
---------------------------------
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
98.61
100%
-76
- C1 -
3BMX
7
NAGZ_BACSU
A:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
98.61
100%
-75
- C1 -
3BMX
8
NAGZ_BACSU
B:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
98.61
100%
-76
- C1 -
3BMX
7
NAGZ_BACSU
A:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
98.41
99%
-76
- C1 -
4GYJ
3
NAGZ_BACSU
A:
[29-646]
------------------------
E
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
98.36
100%
-77
- C1 -
3BMX
7
NAGZ_BACSU
A:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
G
Y
A
N
G
--
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.36
100%
-78
- C1 -
3NVD
4
NAGZ_BACSU
B:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
98.04
99%
-76
- C1 -
4GYJ
3
NAGZ_BACSU
B:
[30-646]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
97.94
100%
-76
- C1 -
3NVD
5
NAGZ_BACSU
A:
[26-642]
-------------------------
A
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
D
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
97.38
99%
-78
- C1 -
3LK6
6
NAGZ_BACSU
C:
[1-616]
--------------------------
S
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
97.07
99%
-78
- C1 -
3LK6
6
NAGZ_BACSU
A:
[2-616]
---------------------------
A
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
97.04
99%
-77
- C1 -
3LK6
6
NAGZ_BACSU
D:
[3-616]
----------------------------
S
K
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
96.77
99%
-78
- C1 -
3LK6
8
NAGZ_BACSU
B:
[5-616]
------------------------------
R
A
I
D
A
N
Q
I
V
N
R
M
S
L
D
E
K
L
G
Q
M
L
M
P
D
F
R
N
W
Q
K
E
G
E
S
S
P
Q
A
L
T
K
M
N
D
E
V
A
S
L
V
K
K
Y
Q
F
G
G
I
I
L
F
A
E
N
V
K
------
T
T
K
Q
T
V
Q
L
T
D
D
Y
Q
--
K
----
A
S
-------
P
----
K
I
P
L
M
L
S
I
D
Q
E
G
G
I
V
T
R
L
-
G
-
E
-
G
-
T
N
-
F
P
G
N
M
A
L
G
A
A
R
S
R
I
N
-
A
Y
Q
T
-------
G
S
I
I
G
K
E
L
S
A
L
G
I
N
T
D
F
S
P
V
V
D
I
N
N
N
P
D
N
P
V
I
G
V
R
S
F
S
S
N
R
E
L
T
S
R
L
G
L
Y
T
M
K
G
L
Q
R
---------
Q
------
D
I
A
S
A
L
K
H
F
P
G
H
G
D
T
D
V
D
S
H
Y
G
L
P
L
V
S
H
G
Q
E
R
L
R
E
V
E
L
Y
P
F
Q
K
A
I
D
A
G
----
A
----
D
M
V
M
T
A
H
V
Q
F
P
A
F
D
D
T
T
Y
K
S
K
L
D
G
S
D
I
L
V
P
A
T
L
S
K
K
V
M
T
G
L
L
R
Q
E
M
G
-
F
N
G
V
I
V
T
N
A
L
N
M
K
A
I
A
D
H
F
--
G
Q
E
E
A
V
V
M
A
V
K
A
G
V
D
I
A
L
M
P
A
S
V
T
S
L
K
E
E
Q
K
F
A
R
V
I
Q
A
L
K
E
A
V
K
N
G
D
I
P
E
Q
Q
I
N
N
S
V
E
R
I
I
S
L
K
I
K
R
G
M
Y
P
A
R
N
S
D
S
T
K
E
K
I
A
K
A
K
K
I
V
G
S
K
Q
H
L
K
A
E
K
K
L
A
E
K
A
V
T
V
L
K
N
E
Q
H
T
L
P
F
K
P
K
K
G
S
R
I
L
I
V
A
P
Y
E
E
Q
T
----
A
S
--------
I
E
----------------
Q
T
I
H
-
D
L
I
K
R
K
K
I
K
P
V
S
L
----
S
K
M
N
F
---------------------
A
S
Q
V
F
K
T
E
H
---
E
K
Q
V
K
E
A
D
Y
I
I
T
G
S
Y
V
V
K
N
D
P
V
V
N
D
G
V
I
D
D
T
I
S
D
S
S
K
W
A
--
T
V
F
P
R
A
V
M
K
A
A
L
Q
H
N
K
P
F
V
L
M
S
-
L
-
R
N
P
Y
D
A
A
N
F
-
E
-
E
A
K
A
L
I
A
V
Y
G
F
K
--
G
Y
A
N
G
R
Y
L
Q
P
N
I
P
A
G
V
M
A
I
F
G
Q
------
A
K
P
K
G
T
L
P
V
D
I
P
S
V
T
K
---------
P
-----------------------------
G
N
T
L
Y
P
L
G
Y
G
L
N
I
K
T
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
74.87
33%
-65
- C1 -
4ZM6
2
?
A:
[8-858]
------------------------------------------
N
L
D
K
E
I
G
Q
L
L
M
C
G
F
D
G
------------
L
E
P
T
P
G
I
I
D
L
I
E
N
H
N
L
G
S
I
I
L
F
S
R
N
I
A
------
T
P
K
Q
V
Q
K
L
T
H
S
L
Q
--
Q
----
I
A
-------
R
N
A
GH
K
R
P
L
F
I
A
V
D
Q
E
N
G
V
V
R
R
L
-
G
-
D
S
G
-
T
Y
-
L
P
G
N
M
A
L
G
A
L
G
S
S
T
A
-
A
R
N
V
-------
A
M
A
I
S
K
E
L
L
T
L
G
M
N
W
N
L
A
P
V
L
D
V
N
N
N
P
L
N
P
V
I
G
V
R
S
Y
G
Q
D
P
E
L
V
A
R
M
G
L
A
Q
V
E
G
Y
Q
R
---------
G
------
K
V
A
T
S
I
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
D
V
P
V
I
N
K
T
L
E
E
L
D
K
T
E
L
V
P
F
K
K
A
L
E
A
G
----
G
IACP
T
S
V
M
V
G
H
M
L
L
P
H
F
N
K
D
------------
V
V
S
S
I
A
P
E
I
V
R
D
L
L
R
R
R
F
G
-
Y
K
G
V
I
I
T
D
C
L
E
M
D
A
V
K
E
T
V
--
G
T
P
K
G
A
L
M
A
L
Q
A
G
N
D
M
A
M
I
S
H
T
L
A
------
F
Q
K
D
A
F
K
V
L
Y
S
A
L
Q
E
G
Q
L
D
K
D
E
I
R
Q
S
L
Q
R
V
A
Q
L
K
D
Q
F
L
N
W
D
D
V
L
Q
Q
A
D
L
K
T
M
-------
G
S
E
A
H
A
T
L
S
K
E
L
Y
D
R
V
P
T
V
V
T
N
R
K
N
T
L
P
I
R
P
A
Q
T
D
K
I
L
F
L
A
A
H
V
P
E
K
----
E
P
--------
F
N
----------------
S
F
H
A
-
S
L
L
K
R
H
T
-------------
N
L
---------------------
E
Y
I
I
Y
N
E
E
T
PDL
S
Q
K
I
Q
E
A
D
W
V
I
I
G
T
------------------
A
N
A
N
L
Y
----
P
F
Q
V
R
M
V
Q
Q
A
Q
K
L
A
K
R
L
V
V
A
A
-
V
-
M
N
P
Y
D
Q
M
C
F
-
P
-
Q
V
D
T
Y
L
V
T
Y
----------
E
Y
T
P
P
A
H
E
A
A
V
R
L
I
F
G
E
------
I
E
T
R
S
R
L
P
I
S
I
P
N
V
D
D
---------
A
-----------------------------
I
A
P
A
T
F
I
V
D
D
Y
R
N
D
D
D
L
D
H
V
T
A
M
W
D
D
I
FGKD
W
P
L
R
K
D
K
I
N
L
G
L
Q
R
AKL
Q
K
H
K
V
A
R
D
SQGKIV
G
F
V
A
T
Q
I
V
V
V
DN
K
K
H
G
Q
LM
L
L
M
V
S
PSYQGKG
V
G
T
L
L
H
D
A
A
L
E
H
F
R
E
Q
GAD
C
I
K
L
G
STYPRFFPGVPDDD
A
Q
S
R
K
A
Q
A
F
F
S
K
K
G
W
R
M
D
D
N
L
V
H
D
L
I
G
D
LQ
D
Y
K
V
P
D
K
I
Q
A
R
M
L
K
E
K
I
W
F
G
R
I
K
PSE
T
W
E
L
Y
A
F
Q
Q
R
NFPHW
L
S
T
Y
Q
H
H
V
E
L
GDYQD
L
I
V
A
R
Q
DDENGRVIA
S
L
I
L
N
T
T
HVSHEYRSDLIWTDDKLFGER
S
G
G
M
AC
V
G
V
A
QEERGRG
I
G
I
G
I
V
A
H
A
N
W
L
L
K
Q
R
GVT
K
S
Y
V
D
WVEL
L
D
F
Y
S
R
V
GYKTW
R
S
Y
R
L
G
H
F
6
PsiBlast_PDB
72.51
31%
-67
- C1 -
4ZM6
1
?
A:
[8-530]
------------------------------------------
N
L
D
K
E
I
G
Q
L
L
M
C
G
F
D
G
L
----
E
P
T
P
G
--------
I
I
D
L
I
E
N
H
N
L
G
S
I
I
L
F
S
R
N
I
A
------
T
P
K
Q
V
Q
K
L
T
H
S
L
Q
--
Q
I
A
R
N
A
G
-------
H
----
K
R
P
L
F
I
A
V
D
Q
E
N
G
V
V
R
R
L
-
G
-
D
S
G
-
T
Y
-
L
P
G
N
M
A
L
G
A
L
G
S
S
T
A
-
A
R
N
V
-------
A
M
A
I
S
K
E
L
L
T
L
G
M
N
W
N
L
A
P
V
L
D
V
N
N
N
P
L
N
P
V
I
G
V
R
S
Y
G
Q
D
P
E
L
V
A
R
M
G
L
A
Q
V
E
G
Y
Q
R
---------
G
------
K
V
A
T
S
I
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
D
V
P
V
I
N
K
T
L
E
E
L
D
K
T
E
L
V
P
F
K
K
A
L
E
A
G
----
G
IACP
T
S
V
M
V
G
H
M
L
L
P
H
F
N
K
D
------------
V
V
S
S
I
A
P
E
I
V
R
D
L
L
R
R
R
F
G
-
Y
K
G
V
I
I
T
D
C
L
E
M
D
A
V
K
E
T
V
--
G
T
P
K
G
A
L
M
A
L
Q
A
G
N
D
M
A
M
I
S
H
T
L
A
F
Q
K
D
------
A
F
K
V
L
Y
S
A
L
Q
E
G
Q
L
D
K
D
E
I
R
Q
S
L
Q
R
V
A
Q
L
K
D
Q
-----
F
L
N
W
D
D
V
L
Q
Q
--
A
D
L
K
T
M
G
S
E
A
H
A
T
L
S
K
E
L
Y
D
R
V
P
T
V
V
T
N
R
K
N
T
L
P
I
R
P
A
Q
T
D
K
I
L
F
L
A
A
H
V
P
------------------EKEPF-----------
N
S
F
H
A
S
L
L
K
R
H
T
-------------
N
L
---------------------
E
Y
I
I
Y
N
E
E
T
PDL
S
Q
K
I
Q
E
A
D
W
V
I
I
G
T
A
N
A
N
L
Y
P
----------------------
F
Q
V
R
M
V
Q
Q
A
Q
K
L
A
K
R
L
V
V
A
A
-
V
-
M
N
P
Y
D
Q
M
C
F
-
P
-
Q
V
D
T
Y
L
V
T
Y
----------
E
Y
T
P
P
A
H
E
A
A
V
R
L
I
F
G
E
------
I
E
T
R
S
R
L
P
I
S
I
P
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
71.92
31%
-64
- C1 -
4ZM6
1
?
B:
[8-530]
------------------------------------------
N
L
D
K
E
I
G
Q
L
L
M
C
G
F
D
G
L
----
E
P
T
P
G
--------
I
I
D
L
I
E
N
H
N
L
G
S
I
I
L
F
S
R
N
I
A
------
T
P
K
Q
V
Q
K
L
T
H
S
L
Q
--
Q
IARN
A
G
-------
H
----
K
R
P
L
F
I
A
V
D
Q
E
N
G
V
V
R
R
L
-
G
-
D
S
G
-
T
Y
-
L
P
G
N
M
A
L
G
A
L
G
S
S
T
A
-
A
R
N
V
-------
A
M
A
I
S
K
E
L
L
T
L
G
M
N
W
N
L
A
P
V
L
D
V
N
N
N
P
L
N
P
V
I
G
V
R
S
Y
G
Q
D
P
E
L
V
A
R
M
G
L
A
Q
V
E
G
Y
Q
R
---------
G
------
K
V
A
T
S
I
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
D
V
P
V
I
N
K
T
L
E
E
L
D
K
T
E
L
V
P
F
K
K
A
L
E
A
G
----
G
IACP
T
S
V
M
V
G
H
M
L
L
P
H
F
N
K
D
------------
V
V
S
S
I
A
P
E
I
V
R
D
L
L
R
R
R
F
G
-
Y
K
G
V
I
I
T
D
C
L
E
M
D
A
V
K
E
T
V
--
G
T
P
K
G
A
L
M
A
L
Q
A
G
N
D
M
A
M
I
S
H
T
L
A
F
Q
K
D
------
A
F
K
V
L
Y
S
A
L
Q
E
G
Q
L
D
K
D
E
I
R
Q
S
L
Q
R
V
A
Q
L
K
D
Q
-----
F
L
N
W
D
D
V
L
Q
Q
--
A
D
L
K
T
M
G
S
E
A
H
A
T
L
S
K
E
L
Y
D
R
V
P
T
V
V
T
N
R
K
N
T
L
P
I
R
P
A
Q
T
D
K
I
L
F
L
A
A
H
V
P
------------------EKEPF-----------
N
S
F
H
A
S
L
L
K
R
H
T
-------------
N
L
---------------------
E
Y
I
I
Y
N
E
E
T
PDL
S
Q
K
I
Q
E
A
D
W
V
I
I
G
T
A
N
A
N
L
Y
P
----------------------
F
Q
V
R
M
V
Q
Q
A
Q
K
L
A
K
R
L
V
V
A
A
-
V
-
M
N
P
Y
D
Q
M
C
F
-
P
-
Q
V
D
T
Y
L
V
T
Y
----------
E
Y
T
P
P
A
H
E
A
A
V
R
L
I
F
G
E
------
I
E
T
R
S
R
L
P
I
S
I
P
N
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
71.87
34%
-65
- C1 -
4ZM6
1
?
A:
[8-532]
------------------------------------------
N
L
D
K
E
I
G
Q
L
L
M
C
G
F
D
G
L
E
P
------------
T
P
G
I
I
D
L
I
E
N
H
N
L
G
S
I
I
L
F
S
R
N
I
A
------
T
P
K
Q
V
Q
K
L
T
H
S
L
Q
--
Q
----
I
A
-------
R
N
A
GH
K
R
P
L
F
I
A
V
D
Q
E
N
G
V
V
R
R
L
-
G
D
S
-
G
-
T
Y
-
L
P
G
N
M
A
L
G
A
L
G
S
S
T
A
-
A
R
N
V
-------
A
M
A
I
S
K
E
L
L
T
L
G
M
N
W
N
L
A
P
V
L
D
V
N
N
N
P
L
N
P
V
I
G
V
R
S
Y
G
Q
D
P
E
L
V
A
R
M
G
L
A
Q
V
E
G
Y
Q
R
---------
G
------
K
V
A
T
S
I
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
D
V
P
V
I
N
K
T
L
E
E
L
D
K
T
E
L
V
P
F
K
K
A
L
E
A
G
GIAC
P
----
T
S
V
M
V
G
H
M
L
L
P
H
F
N
K
------------
D
V
V
S
S
I
A
P
E
I
V
R
D
L
L
R
R
R
F
G
-
Y
K
G
V
I
I
T
D
C
L
E
M
D
A
V
K
E
T
V
--
G
T
P
K
G
A
L
M
A
L
Q
A
G
N
D
M
A
M
I
S
H
T
L
A
F
Q
------
K
D
A
F
K
V
L
Y
S
A
L
Q
E
G
Q
L
D
K
D
E
I
R
Q
S
L
Q
R
V
A
Q
L
K
D
Q
F
L
N
W
D
D
V
L
Q
Q
-------
A
D
L
K
T
M
G
S
E
A
H
A
T
L
S
K
E
L
Y
D
R
V
P
T
V
V
T
N
R
K
N
T
L
P
I
R
P
A
Q
T
D
K
I
L
F
L
A
A
H
V
P
--------EKE-----
P
F
----------------
N
S
F
H
-
A
S
L
L
K
R
H
T
---
N
L
----
E
Y
I
I
Y
---------------------
N
E
--
E
T
P
D
L
---
S
Q
K
I
Q
E
A
D
W
V
I
I
G
T
A
N
A
N
--------------------
L
--
Y
P
F
Q
V
R
M
V
Q
Q
A
Q
K
L
A
K
R
L
V
V
A
A
-
V
-
M
N
P
Y
D
Q
M
C
F
-
P
-
Q
V
D
T
Y
L
V
T
Y
E
Y
T
----------
P
P
A
H
E
A
A
V
R
L
I
F
G
E
------
I
E
T
R
S
R
L
P
I
S
I
P
N
V
D
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.06
25%
-50
- C1 -
3U48
1
?
A:
[3-623]
------------------------------
M
N
Q
F
I
N
A
L
M
A
K
M
T
L
D
E
K
I
G
Q
L
N
L
P
G
A
G
D
I
T
T
G
--------
Q
A
S
S
S
G
I
A
Q
K
I
K
E
G
K
V
G
G
L
F
N
I
K
----------
S
V
T
K
I
K
E
V
Q
R
I
A
V
EE
S
----
R
--------
L
----
K
I
P
L
L
F
G
M
D
V
I
H
G
Y
---------
E
-
T
A
-
F
P
I
P
L
G
L
S
C
T
W
D
M
E
L
-
I
E
K
S
-------
A
R
I
A
A
I
E
A
S
A
D
G
I
C
W
T
F
S
P
M
V
D
I
S
R
D
P
R
W
G
R
V
S
-
E
G
S
G
E
D
P
Y
L
G
A
Q
I
A
K
A
M
V
K
G
Y
Q
G
---------
K
DFSDNT
S
I
M
A
C
V
K
H
F
A
L
Y
G
A
G
E
A
G
R
D
--
Y
N
T
V
D
M
S
R
V
R
M
Y
N
E
Y
F
P
P
Y
K
A
A
V
D
A
G
----
V
----
G
S
V
M
T
S
F
N
---
E
I
D
G
-------------
I
P
A
T
G
N
K
W
L
M
T
D
V
L
R
K
R
I
G
A
F
K
G
F
V
V
T
D
Y
T
A
I
N
E
M
I
D
H
G
MG
D
L
Q
T
V
S
A
L
A
L
R
A
G
V
D
M
D
M
V
G
E
G
------------
F
L
T
T
L
K
K
S
L
Q
E
G
K
I
T
Q
A
Q
I
D
A
A
C
K
R
I
L
E
A
K
Y
K
L
G
L
F
S
D
P
Y
K
Y
C
N
---
E
E
R
A
R
T
Q
I
F
T
P
E
H
R
K
I
A
R
E
I
A
A
Q
S
F
V
L
L
K
N
D
N
N
V
L
P
L
K
K
S
--
G
T
I
A
L
V
G
P
L
A
D
N
R
VNMP
G
T
WSVAAKHA
E
S
----------------
V
S
L
L
-
E
G
L
K
K
A
A
G
N
D
A
R
I
L
Y
A
H
G
S
N
L
D
ED
K
S
L
I
E
R
A
T
MFGKTLKYDPR
P
K
D
V
V
I
K
E
A
---
V
D
I
A
N
Q
A
D
V
I
V
A
A
L
G
E
S
A
E
M
S
--
G
E
A
S
S
R
S
N
I
E
-----
I
--
P
A
L
Q
R
E
L
L
Q
A
L
L
K
T
G
K
P
V
V
L
V
L
-
F
T
G
R
P
L
A
L
T
W
E
-
H
E
N
V
P
A
I
L
N
V
W
F
A
G
----------
T
E
A
G
D
A
I
S
D
A
L
F
G
V
------
V
N
P
S
G
K
L
S
A
T
F
P
R
N
V
G
QV-------
P
IYYNHKNTGRPLPEGQWFQKFRSNYLDVP
N
D
P
L
Y
P
F
G
Y
G
L
S
F
T
K
F
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
63.71
22%
-47
- C1 -
3RRX
2
?
A:
[20-615]
----------------------------
P
A
V
E
A
Q
I
E
K
L
L
A
K
M
T
I
E
Q
K
V
A
Q
M
I
Q
P
E
I
G
Y
L
T
-----------------
V
E
Q
M
R
K
Y
G
F
G
S
Y
L
N
G
G
N
T
A
P
YGNKRA
D
Q
A
T
W
L
K
Y
A
D
E
M
Y
--
L
----
A
A
M
DSTLDG
I
----
A
I
P
T
V
W
G
T
D
A
M
H
G
H
S
N
V
--
Y
-
G
-
A
-
T
L
-
F
P
H
N
I
G
L
G
A
A
R
D
T
D
L
-
I
K
R
I
-------
G
Q
A
T
A
K
E
V
A
A
T
G
I
E
W
S
F
A
P
T
V
A
V
V
R
D
D
R
W
G
R
-
T
Y
E
S
Y
S
E
D
P
D
L
V
K
R
Y
A
G
E
M
V
T
G
I
Q
G
DVGADFLKG
S
------
N
R
I
A
T
A
K
H
F
V
G
D
G
G
T
E
R
G
V
D
R
G
N
T
L
I
--
D
E
K
G
L
R
D
I
H
S
A
G
Y
F
S
A
I
N
Q
G
----
V
----
Q
S
V
M
A
S
F
N
---
S
W
N
G
-------------
K
R
V
H
G
D
K
H
L
L
T
D
V
L
K
N
Q
L
G
-
F
D
G
F
V
V
S
D
W
N
A
H
K
F
V
E
G
-
C
---
D
L
E
Q
C
A
Q
A
I
N
A
G
V
D
V
I
M
V
P
E
H
F
---------
E
A
F
Y
H
N
T
V
K
Q
V
K
A
G
V
I
A
E
S
R
I
N
D
A
V
R
R
F
L
R
A
K
I
R
W
G
V
F
T
K
S
K
P
S
A
R
P
--
E
S
Q
H
P
Q
W
L
G
A
A
E
H
R
T
L
A
R
E
A
V
R
K
S
L
V
L
L
K
N
N
E
S
I
L
P
I
K
A
S
--
S
R
I
L
V
A
G
K
G
A
N
A
I
N
M
Q
A
G
G
--------
W
S
VSWQGTDNTNSDFPNA
T
S
I
F
-
S
G
L
Q
S
Q
V
T
K
---
A
------------------------------
G
G
K
I
T
L
S
E
S
---
G
E
Y
T
S
K
P
D
V
A
I
V
V
I
G
E
E
P
Y
A
E
--
W
F
G
-
D
I
E
L
L
E
----
F
Q
HE
T
K
H
A
L
A
L
L
K
Q
L
K
A
D
N
I
P
V
V
T
V
F
L
S
-
G
R
P
L
W
V
N
K
E
L
N
-
A
S
D
A
F
V
A
A
W
L
P
G
----------
S
E
G
-
E
G
V
A
D
V
L
L
T
N
KQGKTQ
F
D
F
T
G
K
L
S
F
S
W
P
K
Y
D
D
QFTLNLNDA
D
-----------------------------
Y
D
P
L
F
A
Y
G
Y
G
L
T
Y
Q
D
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.13
39%
-56
- C1 -
3SQL
8
?
A:
[83-351]
-----------------------------------------------------------------------------------------------------------------------------------------
E
I
P
L
L
I
A
A
D
I
E
E
G
V
G
Q
R
F
-
R
-
G
-
A
-
T
E
-
F
P
P
P
M
A
F
G
E
I
W
-
R
T
D
-
P
H
Q
A
I
A
L
A
E
T
M
G
A
T
T
A
Q
E
A
L
S
L
G
I
N
W
V
L
A
P
V
L
D
V
N
N
N
P
H
N
P
V
I
N
I
R
A
F
G
E
T
P
D
Q
V
S
A
L
G
T
A
F
I
R
G
A
Q
Q
---------
Y
------
A
V
L
T
T
A
K
H
F
P
G
H
G
D
T
A
T
D
S
H
L
A
L
P
T
I
S
H
D
D
T
R
L
N
T
V
E
L
P
P
F
K
A
A
I
Q
G
G
----
V
----
D
A
V
M
N
A
H
L
M
I
P
A
W
D
Q
Q
------------
Y
P
A
T
L
S
P
A
I
L
T
G
Q
L
R
H
K
L
G
-
F
K
G
L
I
V
T
D
A
L
V
M
G
G
I
T
Q
F
A
--
A
P
D
T
V
V
V
Q
A
I
A
A
G
A
D
I
L
L
M
P
P
D
V
D
G
---------
A
I
I
A
I
E
T
A
I
K
T
G
Q
L
S
E
S
R
I
Y
E
S
V
E
R
I
W
Q
A
K
Q
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
48.18
30%
-53
- C1 -
4GNV
3
?
A:
[39-291]
--------------------------------------------------------------------------------------
G
G
V
I
L
F
A
R
H
F
Q
------
N
R
A
Q
L
T
A
L
T
D
S
I
R
--
A
----
V
R
-------
E
----
D
I
--
L
I
A
V
D
H
E
G
G
R
V
Q
R
F
R
T
-
D
-
G
F
T
V
-
L
P
A
M
R
R
L
G
E
L
W
D
R
D
V
-
L
L
A
T
K
V
A
T
A
V
-
G
Y
I
L
A
A
E
L
R
A
C
G
I
D
M
S
F
T
P
V
L
D
L
D
Y
G
-
H
S
K
V
I
G
D
R
A
F
H
R
D
P
R
V
V
T
L
L
A
K
S
L
N
H
G
L
S
L
---------
A
------
G
M
A
N
C
G
K
H
F
P
G
H
G
F
A
E
A
D
S
H
V
A
L
P
T
D
D
R
T
L
D
A
I
L
E
Q
D
V
A
P
Y
D
W
-
L
G
L
S
----
L
----
A
A
V
I
P
A
H
V
I
Y
T
Q
V
D
K
R
-------------
P
A
G
F
S
R
V
W
L
Q
D
I
L
R
G
K
L
G
-
F
T
G
A
I
F
S
D
D
L
S
M
E
A
A
R
-----
T
L
T
Q
A
A
D
A
A
L
A
A
G
C
D
M
V
L
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
45.49
30%
-49
- C1 -
1Y65
1
NAGZ_VIBCH
A:
[29-274]
--------------------------------------------------------------------------------------
G
G
V
I
L
F
G
R
N
Y
H
------
D
N
Q
Q
L
L
A
L
N
K
A
I
R
--
Q
----
A
A
------------
K
R
P
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
-
R
-
E
-
G
F
S
R
-
I
P
P
A
Q
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
-------
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
---------
V
------
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
---
Y
D
E
R
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
G
----
V
L---
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
Q
-------------
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
-
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
--
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
44.81
30%
-50
- C1 -
2OXN
1
NAGZ_VIBCH
A:
[2-276]
-------------------------------------------------
G
P
L
W
L
D
V
A
G
Y
E
L
------------
S
A
E
D
R
E
I
L
Q
H
P
T
V
G
G
V
I
L
F
G
R
N
Y
H
------
D
N
Q
Q
L
L
A
L
N
K
A
I
R
--
Q
----
A
A
------------
K
R
P
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
-
R
E
G
-
F
-
S
R
I
P
P
A
Q
Y
Y
A
R
A
E
N
G
V
E
L
-
A
E
Q
G
-------
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
F
A
C
K
A
--
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
---------
V
------
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
Y
D
---
E
R
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
G
V---
L
----
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
-------------
Q
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
-
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
--
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
C
N
K
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
43.84
30%
-46
- C1 -
2OXN
1
NAGZ_VIBCH
A:
[27-272]
--------------------------------------------------------------------------------------
G
G
V
I
L
F
G
R
N
Y
H
------
D
N
Q
Q
L
L
A
L
N
K
A
I
R
--
Q
----
A
A
------------
K
R
P
I
L
I
G
V
D
Q
E
G
G
R
V
Q
R
F
-
R
-
E
-
G
F
S
R
-
I
P
P
A
Q
Y
Y
A
R
A
E
N
G
V
E
L
A
E
Q
G
-------
G
W
L
M
A
A
E
L
I
A
H
D
V
D
L
S
F
A
P
V
L
D
M
G
F
A
--
C
K
A
I
G
N
R
A
F
G
E
D
V
Q
T
V
L
K
H
S
S
A
F
L
R
G
M
K
A
---------
V
------
G
M
A
T
T
G
K
H
F
P
G
H
G
A
V
I
A
D
S
H
L
E
T
P
---
Y
D
E
R
E
T
I
A
Q
D
M
A
I
F
R
A
Q
I
E
A
G
----
V
L---
D
A
M
M
P
A
H
V
V
Y
P
H
Y
D
A
Q
-------------
P
A
S
G
S
S
Y
W
L
K
Q
V
L
R
E
E
L
G
-
F
K
G
I
V
F
S
D
D
L
S
M
E
G
A
A
V
M
G
--
G
P
V
E
R
S
H
Q
A
L
V
A
G
C
D
M
I
L
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------