@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu02260: (2016-06-03 )
MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKTHIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAMETRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFISFHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTENGFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLSLEQPEYVNQRVLSFLCGGIK
Atome Classification :
(20 SA)
.........10........20........30........40.-.......50--........60.---.....---..70.......-.80........90.......---.---100......-.-..110.......120.......130.......140.......150.......160-.-.---.-..-.----.---170-.---..-.---.---.-----.180..-.---.---..-----.---.190.-......200.-----------..-.--------------...210....-------------.-..-----220-..-----..-----.-....230---------........240.......250.......260........270.......280.......290....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MIQD
S
M
Q
F
A
A
V
E
S
G
L
R
F
Y
Q
A
Y
DQSLSLWPIESE
A
F
Y
V
S
TRFG-K
T
H
I
IASGP--KDA
P
S
L
I
L
L
HG---GLFSS---AMWYP
N
I
A
A
W
S
-SQ
F
R
T
Y
A
V
D
I
IGDKNKSI
P
S
---
A
---
A
--
M
E
T
R
A
D
-
F
-
A
E
W
M
K
D
V
F
D
SLGL
E
T
A
H
L
AGLSLG
G
S
H
I
V
N
F
L
LRA
P
E
R
V
E
R
A
V
V
IS
P
A
E
A
F
I
SFH-
P
-
D
---
V
-
Y
K
-
Y
----
A
---
A
E
L-T---GA-R---
G
---
A
-----
E
S
Y
-
I
K
-
W
---I---TG-----D---SY
D
L
H
-
P
L
L
Q
R
Q
I
V
AG-----------VE-W--------------
Q
D
E
QRSLKPT-------------E-NG-----F---
P
Y
-----
V
F-----
T
-
D
Q
E
L
KS----------IQV
P
V
L
L
M
FGE
H
E
A
M
Y
H
Q
Q
M
A
F
E
R
A
S
V
LVP-G
I
Q
A
E
I
V
K
NAG
H
L
LSLEQ
P
E
Y
V
N
Q
R
V
L
S
F
L
CGGIK
1
PsiBlast_PDB
90.18
100%
-126
- C1 -
4CCY
2
YBFK_BACSU
B:
[11-295]
----------
V
E
S
G
L
R
F
Y
Q
A
Y
D
Q
S
L
S
L
W
P
I
E
S
E
A
F
Y
V
S
T
R
F
G
-
K
T
H
I
I
A
S
G
P
--
K
D
A
P
S
L
I
L
L
H
G
---
G
L
F
S
S
---
A
M
W
Y
P
N
I
A
A
W
S
-
S
Q
F
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
S
---
A
---
A
--
M
E
T
R
A
D
-
F
-
A
E
W
M
K
D
V
F
D
S
L
G
L
E
T
A
H
L
A
G
L
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G
G
S
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N
F
L
L
R
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V
I
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A
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A
F
I
S
F
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-
P
-
D
---
V
-
Y
K
-
Y
----
A
---
A
E
L
-
T
---
G
A
-
R
---
G
---
A
-----
E
S
Y
-
I
K
-
W
---
I
---
T
G
-----
D
---
S
Y
D
L
H
-
P
L
L
Q
R
Q
I
V
A
G
-----------
V
E
-
W
--------------
Q
D
E
Q
R
S
L
K
P
T
-------------
E
-
N
G
-----
F
---
P
Y
-----
V
F
-----
T
-
D
Q
E
L
K
S
----------
I
Q
V
P
V
L
L
M
F
G
E
H
E
A
M
Y
H
Q
Q
M
A
F
E
R
A
S
V
L
V
P
-
G
I
Q
A
E
I
V
K
N
A
G
H
L
L
S
L
E
Q
P
E
Y
V
N
Q
R
V
L
S
F
L
C
G
G
I
-
41
HHSearch
89.23
100%
-123
- C1 -
4CCY
2
YBFK_BACSU
A:
[11-295]
----------
V
E
S
G
L
R
F
Y
Q
A
Y
D
Q
S
L
S
L
W
P
I
E
S
E
A
F
Y
V
S
T
R
F
G
-
K
T
H
I
I
A
S
G
P
--
K
D
A
P
S
L
I
L
L
H
G
---
G
L
F
S
S
---
A
M
W
Y
P
N
I
A
A
W
S
-
S
Q
F
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
S
---
A
---
A
--
M
E
T
R
A
D
-
F
-
A
E
W
M
K
D
V
F
D
S
L
G
L
E
T
A
H
L
A
G
L
S
L
G
G
S
H
I
V
N
F
L
L
R
A
P
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R
V
E
R
A
V
V
I
S
P
A
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A
F
I
S
F
H
-
P
-
D
---
V
-
Y
K
-
Y
----
A
---
A
E
L
-
T
---
G
A
-
R
---
G
---
A
-----
E
S
Y
-
I
K
-
W
---
I
---
T
G
-----
D
---
S
Y
D
L
H
-
P
L
L
Q
R
Q
I
V
A
G
-----------
V
E
-
W
--------------
Q
D
E
Q
R
S
L
K
P
T
-------------
E
-
N
G
-----
F
---
P
Y
-----
V
F
-----
T
-
D
Q
E
L
K
S
----------
I
Q
V
P
V
L
L
M
F
G
E
H
E
A
M
Y
H
Q
Q
M
A
F
E
R
A
S
V
L
V
P
-
G
I
Q
A
E
I
V
K
N
A
G
H
L
L
S
L
E
Q
P
E
Y
V
N
Q
R
V
L
S
F
L
C
G
G
I
-
3
PsiBlast_PDB
77.03
59%
-125
- C1 -
2R11
1
NAP_BACSU
A:
[25-304]
-----------
D
N
G
I
R
Y
Y
Q
T
Y
N
E
S
L
S
L
W
P
V
R
C
K
S
F
Y
I
S
T
R
F
G
-
Q
T
H
V
I
A
S
G
P
--
E
D
A
P
P
L
V
L
L
H
G
---
A
L
F
S
S
---
T
M
W
Y
P
N
I
A
D
W
S
-
S
K
Y
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
E
---
N
---
V
--
S
G
T
R
T
D
-
Y
-
A
N
W
L
L
D
V
F
D
N
L
G
I
E
K
S
H
M
I
G
L
S
L
G
G
L
H
T
M
N
F
L
L
R
M
P
E
R
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K
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A
A
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S
P
A
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T
F
L
P
F
H
-
H
-
D
---
F
-
Y
K
-
Y
----
A
---
L
G
L
-
T
---
A
S
-
N
---
G
---
V
-----
E
T
F
-
L
N
-
W
---
M
---
M
N
-----
D
---
Q
N
V
L
H
-
P
I
F
V
K
Q
F
K
A
G
-----------
V
M
-
W
--------------
Q
D
G
S
R
N
P
N
P
N
-------------
A
-
D
G
-----
F
---
P
Y
-----
V
F
-----
T
-
D
E
E
L
R
S
----------
A
R
V
P
I
L
L
L
L
G
E
H
E
V
I
Y
D
P
H
S
A
L
H
R
A
S
S
F
V
P
-
D
I
E
A
E
V
I
K
N
A
G
H
V
L
S
M
E
Q
P
T
Y
V
N
E
R
V
M
R
F
F
-----
42
HHSearch
76.95
59%
-123
- C1 -
4CCW
1
?
A:
[11-292]
----------
S
D
N
G
I
R
Y
Y
Q
T
Y
N
E
S
L
S
L
W
P
V
R
C
K
S
F
Y
I
S
T
R
F
G
-
Q
T
H
V
I
A
S
G
P
--
E
D
A
P
P
L
V
L
L
H
G
---
A
L
F
S
S
---
T
M
W
Y
P
N
I
A
D
W
S
-
S
K
Y
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
E
---
N
---
L
--
S
G
T
R
T
D
-
Y
-
A
N
W
L
L
D
V
F
D
N
L
G
I
E
K
S
H
M
I
G
L
S
L
G
G
L
H
T
M
N
F
L
L
R
M
P
E
R
V
K
S
A
A
I
L
S
P
A
E
T
F
L
P
F
H
-
H
-
D
---
F
-
Y
K
-
Y
----
A
---
L
G
L
-
T
---
A
S
-
N
---
G
---
V
-----
E
K
F
-
L
N
-
W
---
M
---
M
T
-----
D
---
Q
N
V
L
H
-
P
I
F
V
K
Q
F
Q
A
G
-----------
V
M
-
W
--------------
Q
D
G
S
R
N
P
N
P
K
-------------
A
-
D
G
-----
F
---
P
Y
-----
V
F
-----
T
-
D
E
E
L
R
S
----------
A
R
V
P
I
L
L
L
L
G
E
H
E
V
I
Y
D
P
H
S
A
L
H
R
A
S
S
F
V
P
-
D
I
E
A
E
V
I
K
N
A
G
H
V
L
S
M
E
Q
P
A
Y
V
N
E
R
V
M
R
F
F
N
----
2
PsiBlast_PDB
76.40
60%
-124
- C1 -
4CCW
1
?
A:
[12-291]
-----------
D
N
G
I
R
Y
Y
Q
T
Y
N
E
S
L
S
L
W
P
V
R
C
K
S
F
Y
I
S
T
R
F
G
-
Q
T
H
V
I
A
S
G
P
--
E
D
A
P
P
L
V
L
L
H
G
---
A
L
F
S
S
---
T
M
W
Y
P
N
I
A
D
W
S
-
S
K
Y
R
T
Y
A
V
D
I
I
G
D
K
N
K
S
I
P
E
---
N
---
L
--
S
G
T
R
T
D
-
Y
-
A
N
W
L
L
D
V
F
D
N
L
G
I
E
K
S
H
M
I
G
L
S
L
G
G
L
H
T
M
N
F
L
L
R
M
P
E
R
V
K
S
A
A
I
L
S
P
A
E
T
F
L
P
F
H
-
H
-
D
---
F
-
Y
K
-
Y
----
A
---
L
G
L
-
T
---
A
S
-
N
---
G
---
V
-----
E
K
F
-
L
N
-
W
---
M
---
M
T
-----
D
---
Q
N
V
L
H
-
P
I
F
V
K
Q
F
Q
A
G
-----------
V
M
-
W
--------------
Q
D
G
S
R
N
P
N
P
K
-------------
A
-
D
G
-----
F
---
P
Y
-----
V
F
-----
T
-
D
E
E
L
R
S
----------
A
R
V
P
I
L
L
L
L
G
E
H
E
V
I
Y
D
P
H
S
A
L
H
R
A
S
S
F
V
P
-
D
I
E
A
E
V
I
K
N
A
G
H
V
L
S
M
E
Q
P
A
Y
V
N
E
R
V
M
R
F
F
-----
13
PsiBlast_PDB
55.67
23%
-137
- C1 -
4LXI
2
?
A:
[6-273]
--------------------------------
E
S
K
F
I
D
C
D
G
I
-
R
T
H
Y
I
E
M
G
E
--
G
D
--
P
L
V
L
V
H
G
---
G
G
A
G
A
DGR
S
N
F
A
D
N
F
P
I
F
A
-
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
---
P
---
A
GF
A
Y
T
Q
A
A
-
R
-
T
D
H
L
I
S
F
I
K
A
L
G
L
S
K
I
C
L
I
G
N
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
---
V
N
I
S
-
P
-
D
------------------
D
M
-
V
---
A
N
-
R
---
D
---
D
-----
L
A
A
-
V
M
--------------------
S
Y
D
G
S
-
E
E
G
M
R
K
I
I
A
A
L
T
H
S
Y
Q
P
T
D
D
I
V
H
-
Y
--------------
R
H
E
A
-
S
L
R
P
T
T
T
A
A
Y
K
A
T
M
G
W
A
K
Q
-
N
G
-----
L
---
Y
Y
------------
S
-
P
E
Q
L
A
S
----------
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
I
-
L
A
I
P
-
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
-----
10
PsiBlast_PDB
52.75
23%
-133
- C1 -
4LXH
2
?
A:
[6-273]
--------------------------------
E
S
K
F
I
D
C
D
G
I
-
R
T
H
Y
I
E
M
G
E
--
G
D
--
P
L
V
L
V
H
G
---
G
G
A
G
A
DGR
S
N
F
A
D
N
F
P
I
F
A
-
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
---
P
---
A
GF
A
Y
T
Q
A
A
-
R
-
T
D
H
L
I
S
F
I
K
A
L
G
L
S
K
I
C
L
I
G
N
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
---
V
N
I
S
-
P
-
D
------------------
D
M
-
V
---
A
N
-
R
---
D
---
D
-----
L
A
A
-
V
M
--------------------
S
Y
D
G
S
-
E
E
G
M
R
K
I
I
A
A
L
T
HS
Y
Q
P
T
D
D
I
V
H
-
Y
--------------
R
H
E
A
-
S
L
R
P
T
T
T
A
A
Y
K
A
T
M
G
W
A
K
Q
-
N
G
-----
L
---
Y
Y
------------
S
-
P
E
Q
L
A
S
----------
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
I
-
L
A
I
P
-
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
-----
9
PsiBlast_PDB
52.28
23%
-133
- C1 -
4LXG
3
?
A:
[6-273]
--------------------------------
E
S
K
F
I
D
C
D
G
I
-
R
T
H
Y
I
E
M
G
E
--
G
D
--
P
L
V
L
V
H
G
---
G
G
A
G
A
DGR
S
N
F
A
D
N
F
P
I
F
A
-
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
---
P
---
A
GF
A
Y
T
Q
A
A
-
R
-
T
D
H
L
I
S
F
I
K
A
L
G
L
S
K
I
C
L
I
G
N
S
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
---
V
N
I
S
-
P
-
D
------------------
D
M
-
V
---
A
------
D
---
D
-----
L
A
A
-
V
M
--------------------
S
Y
D
G
S
-
E
E
G
M
R
K
I
I
A
A
L
T
HS
Y
Q
P
T
D
D
I
V
H
-
Y
--------------
R
H
E
A
-
S
L
R
P
T
T
T
A
A
Y
K
A
T
M
G
W
A
K
Q
-
N
G
-----
L
---
Y
Y
------------
S
-
P
E
Q
L
A
S
----------
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
I
-
L
A
I
P
-
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
-----
12
PsiBlast_PDB
52.08
23%
-135
- C1 -
4LYE
1
?
A:
[6-273]
--------------------------------
E
S
K
F
I
D
C
D
G
I
-
R
T
H
Y
I
E
M
G
E
--
G
D
--
P
L
V
L
V
H
G
---
G
G
A
G
A
DGR
S
N
F
A
D
N
F
P
I
F
A
-
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
---
P
---
A
GF
A
Y
T
Q
A
A
-
R
-
T
D
H
L
I
S
F
I
K
A
L
G
L
S
K
I
C
L
I
G
N
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
---
V
N
I
S
-
P
-
D
------------------
D
M
-
V
---
A
N
-
R
---
D
---
D
-----
L
A
A
-
V
M
--------------------
S
Y
D
G
S
-
E
E
G
M
R
K
I
I
A
A
L
T
HS
Y
Q
P
T
D
D
I
V
H
-
Y
--------------
R
H
E
A
-
S
L
R
P
T
T
T
A
A
Y
K
A
T
M
G
W
A
K
Q
-
N
G
-----
L
---
Y
Y
------------
S
-
P
E
Q
L
A
S
----------
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
I
-
L
A
I
P
-
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
-----
19
PsiBlast_PDB
51.87
22%
-125
- C1 -
4O08
5
?
A:
[39-319]
-----------------------------------
Y
I
N
V
N
G
V
-
N
L
H
Y
I
S
K
G
Q
--
G
E
L
--
M
L
F
L
H
G
---
F
P
D
F
S
---
H
I
W
R
H
Q
I
D
E
F
S
-
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
---
G
---
L
--
E
S
Y
E
I
D
V
L
-
V
E
D
I
R
Q
V
I
E
G
L
G
Y
S
S
C
T
L
V
V
H
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
------
A
F
N
G
P
H
-
P
-------
Y
T
-
F
----
M
---
R
E
L
-
R
---
T
N
-
K
---
N
Q
Q
K
A
-----
S
E
Y
-
M
K
-
W
---
F
---
Q
----------
K
Q
E
V
Q
-
D
Y
M
E
R
D
N
F
S
G
-----------
L
R
-
K
L
V
I
D
P
G
V
K
K
GYLT
A
D
D
V
Q
A
Y
M
N
S
W
-------------
E
-
N
G
S
V
L
S
M
L
---
S
Y
Y
R
N
LK
I
F
-----
T
-
E
E
D
L
R
R
KSLFPLEEEV
L
N
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
-
N
L
D
G
I
E
E
Y
V
P
-
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
-----
11
PsiBlast_PDB
51.48
23%
-134
- C1 -
4LYD
-
?
A:
[6-273]
--------------------------------
E
S
K
F
I
D
C
D
G
I
-
R
T
H
Y
I
E
M
G
E
--
G
D
--
P
L
V
L
V
H
G
---
G
G
A
G
A
DGR
S
N
F
A
D
N
F
P
I
F
A
-
R
H
M
R
V
I
A
Y
D
M
V
G
F
G
Q
T
D
A
P
D
---
P
---
A
GF
A
Y
T
Q
A
A
-
R
-
T
D
H
L
I
S
F
I
K
A
L
G
L
S
K
I
C
L
I
G
N
A
M
G
G
T
T
A
C
G
A
A
L
K
A
P
E
L
I
D
R
L
V
L
M
G
A
A
---
V
N
I
S
-
P
-
D
------------------
D
M
-
V
---
A
N
-
R
----------------------------------------
Y
D
G
S
-
E
E
G
M
R
K
I
I
A
A
L
T
H
S
Y
Q
P
T
D
D
I
V
H
-
Y
--------------
R
H
E
A
-
S
L
R
P
T
T
T
A
A
Y
K
A
T
M
G
W
A
K
Q
-
N
G
-----
L
---
Y
Y
------------
S
-
P
E
Q
L
A
S
----------
L
T
M
P
V
L
V
L
G
G
K
N
D
V
M
V
P
V
R
K
V
I
D
Q
I
-
L
A
I
P
-
Q
A
I
G
H
V
F
P
N
C
G
H
W
V
M
I
E
Y
P
E
E
F
C
T
Q
T
L
H
F
F
-----
18
PsiBlast_PDB
48.13
22%
-125
- C- -
4NZZ
-
?
A:
[5-285]
-----------------------------------
Y
I
N
V
N
G
V
-
N
L
H
Y
I
S
K
G
Q
--
G
E
L
--
M
L
F
L
H
G
---
F
P
D
F
S
---
H
I
W
R
H
Q
I
D
E
F
S
-
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
---
G
---
L
--
E
S
Y
E
I
D
V
L
-
V
E
D
I
R
Q
V
I
E
G
L
G
Y
S
S
C
T
L
V
V
H
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
------
A
F
N
G
P
H
-
P
-------
Y
T
-
F
----
M
---
R
E
L
-
R
---
T
N
-
K
---
N
Q
Q
K
A
-----
S
E
Y
-
M
K
-
W
---
F
---
Q
----------
K
Q
E
V
Q
-
D
Y
M
E
R
D
N
F
S
G
-----------
L
R
-
K
L
V
I
D
P
G
V
K
K
GYLT
A
D
D
V
Q
A
Y
M
N
S
W
-------------
E
-
N
G
S
V
L
S
M
L
---
S
Y
Y
R
N
LK
I
F
-----
T
-
E
E
D
L
R
R
KSLFPLEEEV
L
N
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
-
N
L
D
G
I
E
E
Y
V
P
-
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
-----
56
HHSearch
46.75
14%
-139
- C1 -
3W06
6
KAI2_ARATH
A:
[11-270]
---------------------------------------------
N
V
K
V
I
G
S
---
G
E
A
T
I
V
L
G
H
G
---
F
G
T
D
Q
---
S
V
W
K
H
L
V
P
H
L
V
-
D
D
Y
R
V
V
L
Y
D
N
M
G
A
G
T
T
N
P
D
Y
---
F
DFD
R
--
Y
S
N
L
E
G
-
Y
-
S
F
D
L
I
A
I
L
E
D
L
K
I
E
S
C
I
F
V
G
H
S
V
S
A
M
I
G
V
L
A
S
L
N
R
P
D
L
F
S
K
I
V
M
I
S
A
S
P
R
Y
V
N
D
V
D
Y
-
Q
G--
G
-
F
E
Q
E
----
D
---
L
N
Q
-
L
---
F
E
-
A
---
I
---
R
-----
S
N
Y
-
K
A
-
W
---
C
L
G
F
A
P
-----
L
A
V
-
G
G
D
M
D
-
S
I
A
V
Q
E
F
S
R
T
-----------
L
F
-
N
--------------
M
R
P
D
I
-
A
L
S
V
-------------
G
-
Q
T
-----
I
---
F
Q
-----
S
D
-----
M
-
R
Q
I
L
P
F
----------
V
T
V
P
C
H
I
L
Q
S
V
K
D
L
A
V
P
V
V
V
-
S
E
Y
L
H
A
N
L
G
C
E
S
V
V
E
V
I
P
S
D
G
H
L
P
Q
L
S
S
P
D
S
V
I
P
V
I
L
R
H
I
R
N
D
I
-
58
HHSearch
46.11
16%
-127
- C1 -
3QVM
4
?
A:
[24-278]
-------------------------------------------------
T
G
G
---
G
E
K
T
V
L
L
A
H
G
---
F
G
C
D
Q
---
N
M
W
R
F
M
L
P
E
L
E
-
K
Q
F
T
V
I
V
F
D
Y
V
G
S
G
Q
S
D
L
E
S
FST
K
---
R
--
Y
S
S
L
E
G
-
Y
-
A
K
D
V
E
E
I
L
V
A
L
D
L
V
N
V
S
I
I
G
H
S
V
S
S
I
I
A
G
I
A
S
T
H
V
G
D
R
I
S
D
I
T
M
I
C
P
S
P
C
F
M
N
F
P
-
P
-
D
YVG
G
-
F
E
R
D
----
D
---
L
E
E
-
L
---
I
N
-
L
---
M
---
D
-----
K
N
Y
-
I
G
-
W
A
N
Y
L
---
A
P
-----
L
VM-
G
A
S
H
S
-
S
E
L
I
G
E
L
S
G
S
-----------
F
C
-
T
--------------
T
D
P
I
V
A
K
T
-
F
-------------
A
-
K
A
-----
T
---
F
F
-----
S
D
-----
Y
-
R
S
L
L
E
D
----------
I
S
T
P
A
L
I
F
Q
S
A
K
D
S
L
A
S
P
E
V
-
G
Q
Y
M
A
E
N
I
P
-
N
S
Q
L
E
L
I
Q
A
E
G
H
C
L
H
M
T
D
A
G
L
I
T
P
L
L
I
H
F
I
Q
N
N
--
53
HHSearch
45.20
19%
-114
- C1 -
4INZ
2
?
A:
[19-304]
--------------------------------
S
K
Q
Y
I
N
V
N
G
V
-
N
L
H
Y
I
S
K
G
Q
----
G
E
L
M
L
F
L
H
G
---
F
P
D
F
S
---
H
I
W
R
H
Q
I
D
E
F
S
-
N
D
F
H
T
V
A
L
D
L
R
G
Y
N
L
S
E
K
P
S
---
G
L--
E
--
S
Y
E
I
D
V
-
L
-
V
E
D
I
R
Q
V
I
E
G
L
G
Y
S
S
C
T
L
V
V
H
D
W
G
A
G
I
G
W
T
F
A
Y
R
Y
P
E
Y
V
Q
K
L
I
A
F
N
G
P
H
P
Y
T
F
M
R
-
E
L
R
---
T
N
K
N
Q
Q
----
K
A
S
E
Y
A
K
W
F
---
Q
K
Q
E
V
Q
D
Y
---
M
E
RDNF
S
G
L
-
R
K
-
L
---
V
---
I
D
-----
P
G
V
K
K
G
Y
L
T
A
D
D
V
Q
A
Y
M
N
S
W
-----------
E
N
G
S
--------------
V
L
S
M
L
S
Y
Y
R
N
-------------
L
-
K
I
-----
F
---
T
E
-----
E
D
L
R
RKS
L
F
P
L
E
E
E
V
----------
L
N
I
P
V
Q
I
I
W
G
N
Q
D
P
T
F
M
P
E
N
-
L
D
G
I
E
E
Y
V
P
-
N
I
S
V
H
R
L
A
E
A
S
H
A
P
Q
H
E
K
P
Q
E
V
N
N
V
M
W
N
F
L
N
K
---
20
PsiBlast_PDB
44.32
21%
-129
- C1 -
1IUN
1
?
A:
[28-270]
-----------------------------------------------------------
V
I
L
I
H
G
S
G
P
G
V
S
A
Y
---
A
N
W
R
L
T
I
P
A
L
S
-
K
F
Y
R
V
I
A
P
D
M
V
G
F
G
F
T
D
R
P
E
---
N
---
Y
--
N
Y
S
K
D
S
-
W
-
V
D
H
I
I
G
I
M
D
A
L
E
I
E
K
A
H
I
V
G
N
A
F
G
G
G
L
A
I
A
T
A
L
R
Y
S
E
R
V
D
R
M
V
L
M
G
A
A
G
T
R
F
D
V
T
-
E
-
G
L
N
A
V
-
W
G
-
Y
----
T
---
P
S
I
-
E
---
N
M
-
R
---
N
---
L
-----
L
D
I
-
F
A
-
Y
---
D
---
R
S
-----
L
---
V
T
D
E
L
-
A
R
L
R
Y
E
A
S
I
Q
-----------
P
G
-
F
--------------
Q
E
S
F
S
S
M
F
P
E
-------------
P
-
R
Q
-----
R
W
I
D
A
L
-----
A
S
-----
S
-
D
E
D
I
K
T
----------
L
P
N
E
T
L
I
I
H
G
R
E
D
Q
V
V
P
L
S
S
S
L
-
R
L
G
E
L
I
D
-
R
A
Q
L
H
V
F
G
R
C
G
H
W
T
Q
I
E
Q
T
D
R
F
N
R
L
V
V
E
F
F
-----
57
HHSearch
42.96
16%
-112
- C1 -
1WOM
11
RSBQ_BACSU
A:
[9-270]
-----------------------------------------
S
-
R
N
H
V
K
V
K
G
S
---
G
K
A
S
I
M
F
A
P
G
---
F
G
C
D
Q
---
S
V
W
N
A
V
A
P
A
F
E
-
E
D
H
R
V
I
L
F
D
Y
V
G
S
G
H
S
D
L
R
A
---
Y
DLN
R
--
Y
Q
T
L
D
G
-
Y
-
A
Q
D
V
L
D
V
C
E
A
L
D
L
K
E
T
V
F
V
G
H
S
V
G
A
L
I
G
M
L
A
S
I
R
R
P
E
L
F
S
H
L
V
M
V
G
P
S
P
C
Y
L
N
D
P
-
P
-
E
---
Y
-
Y
G
-
G
FE
E
E
Q
---
L
L
G
-
L
---
L
E
-
M
---
M
---
E
-----
K
N
Y
-
I
G
-
W
---
A
---
T
V
F
A
A
T
V
L
---
N
Q
P
D
R
-
P
E
I
K
E
E
L
E
S
R
-----------
F
C
-
S
--------------
T
D
--
P
V
I
A
R
Q
-------------
F
A
K
A
-----
A
---
F
F
-----
S
D
-----
H
-
R
E
D
L
S
K
----------
V
T
V
P
S
L
I
L
Q
C
A
D
D
I
I
A
P
A
T
V
-
G
K
Y
M
H
Q
H
L
P
-
Y
S
S
L
K
Q
M
E
A
R
G
H
C
P
H
M
S
H
P
D
E
T
I
Q
L
I
G
D
Y
L
K
A
H
--
48
HHSearch
41.90
21%
-103
* C1 *
2XUA
-
?
A:
[7-264]
------------------------------------
A
A
V
N
G
T
-
E
L
H
Y
R
I
D
G
E
RH
G
N
A
P
W
I
V
L
S
N
S
---
L
G
T
D
L
---
S
M
W
A
P
Q
V
A
A
L
S
-
K
H
F
R
V
L
R
Y
D
T
R
G
H
G
H
S
E
A
P
K
---
G
------
P
Y
T
I
E
Q
-
L
-
T
G
D
V
L
G
L
M
D
T
L
K
I
A
R
A
N
F
C
G
L
S
M
G
G
L
T
G
V
A
L
A
A
R
H
A
D
R
I
E
R
V
A
L
C
N
T
A
A
R
I
G
S
P
E
---
V
---
W
-
V
P
-
R
----
A
---
V
K
A
-
R
T
EG
M
H
-
A
---
L
---
A
-----
D
A
V
L
P
R
-
W
---
F
---
T
A
-----
D
---
Y
M
E
R
E
-
P
V
V
L
A
M
I
R
D
V
-----------
F
V
-
H
--------------
T
D
K
E
-
G
Y
A
S
N
-------------
C
-
E
A
-----
I
---
D
A
-----
A
D
-----
L
-
R
P
E
A
P
G
----------
I
K
V
P
A
L
V
I
S
G
T
H
D
L
A
A
T
P
A
Q
-
G
R
E
L
A
Q
A
I
A
-
G
A
R
Y
V
E
L
-
D
A
S
H
I
S
N
I
E
R
A
D
A
F
T
K
T
V
V
D
F
L
T
E
---
43
HHSearch
41.30
22%
-113
- C1 -
3OM8
2
?
A:
[12-266]
--------------------------------------
S
D
G
A
-
S
L
A
Y
R
L
D
G
A
--
A
E
K
P
L
L
A
L
S
N
S
---
I
G
T
T
L
---
H
M
W
D
A
Q
L
P
A
L
T
-
R
H
F
R
V
L
R
Y
D
A
R
G
H
G
A
S
S
V
P
P
---
G
------
P
Y
T
L
A
R
-
L
-
G
E
D
V
L
E
L
L
D
A
L
E
V
R
R
A
H
F
L
G
L
S
L
G
G
I
V
G
Q
W
L
A
L
H
A
P
Q
R
I
E
R
L
V
L
A
N
T
S
A
W
L
G
P
A
A
Q
W
-
D
---
E
R
I
A
-
A
----
V
---
L
Q
A
-
E
D--
M
S
-
E
---
T
---
A
-----
A
G
F
-
L
G
N
W
---
F
---
P
P
-----
A
---
L
L
E
R
A
-
E
P
V
V
E
R
F
R
A
M
-----------
L
M
-
A
--------------
T
N
R
H
-
G
L
A
G
S
-------------
F
-
A
A
-----
V
---
R
D
-----
T
D
-----
L
-
R
A
Q
L
A
R
----------
I
E
R
P
T
L
V
I
A
G
A
Y
D
T
V
T
A
A
S
H
-
G
E
L
I
A
A
S
I
A
-
G
A
R
L
V
T
L
P
-
A
V
H
L
S
N
V
E
F
P
Q
A
F
E
G
A
V
L
S
F
L
G
A
---
25
PsiBlast_CBE
41.15
32%
-158
- C1 -
1CR6
1
HYES_MOUSE
B:
[239-367]
-----------------------------------
Y
V
T
V
K
P
G
I
R
L
H
F
V
E
M
G
----
S
G
P
A
L
C
L
C
H
G
---
F
P
E
S
W
---
F
S
W
R
Y
Q
I
P
A
L
A
Q
A
G
F
R
V
L
A
I
D
M
K
G
Y
G
D
S
S
S
P
P
---
E
---
I
--
E
E
Y
A
M
E
-
L
L
C
K
E
M
V
T
F
L
D
K
L
G
I
P
Q
A
V
F
I
G
H
D
W
A
G
V
M
V
W
N
M
A
L
F
Y
P
E
R
V
-
R
A
V
A
-
S
L
N
T
P
F
M
P
P
D
-
P
-
D
---
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------