@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22700: (2016-07-05 )
MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTDEEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIAFGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQPKAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMIFKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALYISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLNELGKVADHTFSRNELESWLNKWRLEETS
Atome Classification :
(39 SA)
.........10........20..--..-....30......---..40........50........60-.-------.----.--------..--...-70--.........80........90..--....-..100........110.......120.......130...-....140.......150.......160.......170.......180.......190..---..---..-.200.-....-----...-210------------...---------....---..220.......230.......240.......250.....-.-.260.......270---....-------...-.280-...-.-...-.290---.........300..-.----------.-..---------.310----------.......320.-----......330...-....340.--.------.....350.......360----
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
T
L
H
V
Q
TASSSY
P
V
F
I
GQ
G
I
R
K
--
K
A
-
C
E
L
L
T
S
LNRP
L
T
---
R
I
M
F
VT
D
E
E
V
D
R
L
Y
G
D
E
M
L
H
L
L
Q
E-K-------W----P--------
V
K
--
K
V
T-V---PSGEQA
K
S
M
D
M
Y
T
K
L
Q
S
E
A
I
R
F
H--MDRS-
S
C
I
-
I
A
FGG
G
V
V
G
D
L
A
G
F
V
A
A
T
F
M
RGI
D
F
IQM
P
T
T
L
LAH-DSAVG
G
K
V
A
VNHPL
G
K
N
L
I
G
A
FYQP
K
A
V
L
Y
D
T
D
F
L
R
SL
P
E
K
E
L
R
S
G
M
A
E
V
I
K
H
A
F
I
Y
D
R
---
A
F
---
L
E
-
E
L
-
L
N
-
I
H
S
L
-----
R
D
I
-
T
--------------
N
D
Q
---------
L
N
D
M
---
I
F
KGI
S
I
K
A
S
V
V
Q
Q
D
E
K
E
E
G
I
R
A
Y
L
N
F
G
H
TLG
H
A
V
E
AEYG-Y-GQITHG
D
A
V
A
L
G
M
----
Q
F
A
L
-------
Y
I
S-EKT--VG
C
-
E
-
M
D
R
-
K
R
-----
L
V
S
W
L
K
SLG
Y
P
S
Q
I
-
R
----------K-E
T
---------
E
T
S
V
----------
L
L
N
R
M
MNDKKT-----RG
G
K
I
Q
F
I
V
L
N
E
-
L
G
K
V
A
DHT--F------
S
R
N
E
L
E
S
W
L
N
KWRLEETS----
1
PsiBlast_PDB
87.29
40%
-68
- C3 -
3OKF
9
AROB_VIBCH
A:
[30-370]
M
E
R
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
--
N
P
-
A
L
L
S
L
S
A
K
Q
------
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
D
H
-
I
-------
G
----
C
--------
Q
H
--
A
L
L
E
L
---
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
D
-
V
V
V
-
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
---
A
F
---
F
D
-
W
L
E
A
Q
-
M
E
A
L
-----
Y
A
L
-
D
--------------
E
Q
A
---------
L
T
Y
A
---
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
-
Y
-
G
N
W
L
H
G
E
A
V
S
A
G
T
----
V
M
A
A
-------
K
T
A
-
Q
L
Q
--
G
L
I
-
D
-
A
S
Q
F
E
R
-----
I
L
A
I
L
K
K
A
H
L
P
V
R
T
-
P
----------
E
-
N
M
---------
T
F
A
D
----------
F
M
Q
H
M
M
R
D
K
K
V
-----
L
A
G
E
L
R
L
V
L
P
T
S
-
I
G
T
S
A
----------------------------------
41
HHSearch
86.37
40%
-44
- C3 -
3OKF
9
AROB_VIBCH
A:
[33-388]
---
I
T
V
N
L
G
E
R
S
Y
P
I
S
I
G
A
G
L
F
A
--
N
P
-
A
L
L
S
---
L
S
A
K
Q
---
K
V
V
I
V
T
N
H
T
V
A
P
L
Y
A
P
A
I
I
S
L
L
D
H
-
I
------------
G
--------
C
Q
H
A
L
L
E
-
L
---
P
D
G
E
Q
Y
K
T
L
E
T
F
N
T
V
M
S
F
L
L
E
H
N
--
Y
S
R
D
-
V
V
V
-
I
A
L
G
G
G
V
I
G
D
L
V
G
F
A
A
A
C
Y
Q
R
G
V
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
V
N
H
P
L
G
K
N
M
I
G
A
F
Y
Q
P
K
A
V
V
I
D
T
D
C
L
T
T
L
P
A
R
E
F
A
A
G
M
A
E
V
I
K
Y
G
I
I
Y
D
S
---
A
F
---
F
D
-
W
L
-
E
A
Q
M
E
A
L
-----
Y
A
L
-
D
--------------
E
Q
A
---------
L
T
Y
A
---
I
A
R
C
C
Q
I
K
A
E
V
V
A
Q
D
E
K
--
G
I
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
A
H
M
G
-
Y
G
N
-
W
L
H
G
E
A
V
S
A
G
T
----
V
M
A
A
-------
K
T
A
-
Q
L
Q
--
G
L
I
-
D
A
S
Q
F
-
E
R
-----
I
L
A
I
L
K
K
A
H
L
P
V
R
T
-
P
----------
E
-
N
M
---------
T
F
A
D
----------
F
M
Q
H
M
M
R
D
K
K
V
-----
L
A
G
E
L
R
L
V
L
P
T
S
-
I
G
T
S
A
V
V
K
--
G
V-----
P
E
A
V
I
A
Q
A
I
E
Y
C
R
---------
22
PsiBlast_CBE
85.99
38%
-101
- C3 -
1XAH
2
AROB_STAAR
B:
[3-333]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
-
G
T
Y
L
N
Q
F
D
Q
S
F
L
---
L
I
----
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
-------------------
N
--------
V
H
--
K
V
I
-
I
---
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
-
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
---
S
A
---
T
Q
-
D
I
-
E
Q
-
H
F
K
D
-----
R
E
I
-
L
--------------
Q
S
----------
L
N
G
M
DKY
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
----
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
----
I
Y
Q
F
-------
I
V
A
-
N
A
L
--
F
D
S
-
K
-
H
D
I
-
S
H
-----
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
-----------------------------
T
----------
L
Y
Q
Y
M
L
-------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
----------------------------------
21
PsiBlast_CBE
85.60
38%
-87
- C3 -
1XAI
3
AROB_STAAR
B:
[3-333]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
-
G
T
Y
L
N
Q
F
D
Q
S
F
L
---
L
I
----
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
D
I
L
S
Y
-
E
------------
N
--------
V
H
--
K
V
I
-
I
---
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
-
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
---
S
A
---
T
Q
-
D
I
-
E
Q
-
H
F
K
D
-----
R
E
I
-
L
--------------
Q
S
----------
L
N
G
M
DKY
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
----
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
----
I
Y
Q
F
-------
I
V
A
-
N
A
L
--
F
D
S
-
K
-
H
D
I
-
S
H
-----
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
-
I
----------
T
-
D
L
---------
D
F
E
T
----------
L
Y
Q
Y
M
L
S
D
K
K
N
-----
D
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
----------------------------------
3
PsiBlast_PDB
85.42
38%
-87
- C3 -
1XAI
3
AROB_STAAR
A:
[3-333]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
-
G
T
Y
L
N
Q
F
D
Q
S
F
L
---
L
I
----
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
D
I
L
S
Y
-
E
------------
N
--------
V
H
--
K
V
I
-
I
---
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
-
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
---
S
A
---
T
Q
-
D
I
-
E
Q
-
H
F
K
D
-----
R
E
I
-
L
--------------
Q
S
----------
L
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
----
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
----
I
Y
Q
F
-------
I
V
A
-
N
A
L
--
F
D
S
-
K
-
H
D
I
-
S
H
-----
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
-
I
----------
T
-
D
L
---------
D
F
E
T
----------
L
Y
Q
Y
M
L
S
D
K
K
N
-----
D
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
----------------------------------
2
PsiBlast_PDB
85.28
38%
-85
- C3 -
1XAG
5
AROB_STAAR
A:
[3-333]
---
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
-
G
T
Y
L
N
Q
F
D
Q
S
F
L
---
L
I
----
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
D
I
L
S
Y
-
E
------------
N
--------
V
H
--
K
V
I
-
I
---
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
-
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
---
S
A
---
T
Q
-
D
I
-
E
Q
-
H
F
K
D
-----
R
E
I
-
L
--------------
Q
S
----------
L
N
G
M
D
K
Y
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
----
Y
-
H
K
I
P
H
G
H
A
V
M
V
G
I
----
I
Y
Q
F
-------
I
V
A
-
N
A
L
--
F
D
S
-
K
-
H
D
I
-
S
H
-----
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
M
-
I
----------
T
-
D
L
---------
D
F
E
T
----------
L
Y
Q
Y
M
L
S
D
K
K
N
-----
D
K
Q
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
----------------------------------
45
HHSearch
81.33
39%
-28
* C3 *
3ZOK
9
DHQS_ACTCH
A:
[16-377]
--
I
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
-
D
L
L
Q
R
--
H
V
H
G
K
---
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
T
N
-
E
N------
P
----
N
--------
V
S
V
E
S
V
I
-
L
---
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
-
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
---
N
F
---
F
E
-
W
Q
-
E
K
N
M
P
A
L
-----
M
A
R
-
D
--------------
P
S
A
---------
L
A
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
-
Y
G
Q
-
W
L
H
G
E
A
V
A
A
G
M
----
V
M
A
V
-------
D
M
S
-
Y
R
L
--
G
W
I
-
D
E
S
I
V
-
N
R
-----
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
-
P
----------
E
-
T
M
---------
T
V
E
M
----------
F
K
S
V
M
A
V
D
K
K
V
-----
A
D
G
L
L
R
L
I
L
L
K
G
P
L
G
N
C
V
F
T
G
--
D
Y-----
D
R
K
A
L
D
E
T
L
H
A
F
C
K
--------
25
PsiBlast_CBE
81.15
39%
-44
- C3 -
3ZOK
11
DHQS_ACTCH
B:
[17-360]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
-
D
L
L
Q
R
H
V
H
G
--
K
---
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
T
N
-
E
-------
N
----
P
NVS-----
V
E
--
S
V
I
-
L
---
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
-
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
---
N
F
---
F
E
W
Q
E
-
K
N
-
M
P
A
L
-----
M
A
R
-
D
--------------
P
S
A
---------
L
A
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
-
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
----
V
M
A
V
DMSYRLG
W
I
D
-
E
S
I
--
V
---------
N
R
-----
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
-
P
----------
E
-
T
M
---------
T
V
E
M
----------
F
K
S
V
M
A
V
D
K
K
V
-----
A
D
G
L
L
R
L
I
L
L
K
---
G
P
L
G
N
C
V
--
F
------
T
---------------------
4
PsiBlast_PDB
81.06
39%
-43
- C3 -
3ZOK
9
DHQS_ACTCH
A:
[17-360]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
-
D
L
L
Q
R
H
V
H
G
--
K
---
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
T
N
-
E
-------
N
----
P
N
V
S
-----
V
E
--
S
V
I
-
L
---
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
-
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
---
N
F
---
F
E
W
Q
E
-
K
N
-
M
P
A
L
-----
M
A
R
-
D
--------------
P
S
A
---------
L
A
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
-
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
----
V
M
A
V
D
M
S
Y
R
L
G
W
I
D
-
E
S
I
--
V
---------
N
R
-----
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
-
P
----------
E
-
T
M
---------
T
V
E
M
----------
F
K
S
V
M
A
V
D
K
K
V
-----
A
D
G
L
L
R
L
I
L
L
K
---
G
P
L
G
N
C
V
--
F
------
T
---------------------
44
HHSearch
80.83
36%
-39
- C3 -
5EKS
2
?
A:
[9-366]
M
Q
T
L
H
V
E
L
G
E
R
R
Y
P
I
F
I
G
S
Q
L
D
P
--
K
--
Q
L
L
E
P
--
Y
I
H
G
Q
---
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
E
S
-
L
------------
G
K
T
------
V
A
--
T
C
I
-
L
---
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
D
-
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
G
D
E
---
D
F
---
L
V
-
W
L
-
E
E
N
M
D
G
L
-----
V
A
R
-
D
--------------
A
D
L
---------
L
A
E
A
---
V
Y
R
S
C
A
H
K
A
R
I
V
A
N
D
E
K
E
---
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
-
Y
G
T
-
W
L
H
G
E
A
V
A
T
G
M
----
V
M
A
A
-------
D
L
S
-
Q
R
L
--
G
W
I
-
S
N
E
D
V
-
A
R
-----
T
K
K
I
I
Q
R
A
N
L
P
I
S
C
-
P
----------
Q
--
I
---------
P
L
D
D
----------
F
L
G
Y
M
A
H
D
K
K
V
--------
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
A
V
I
T
K
--
D
F-----
D
V
E
L
M
K
Q
A
I
L
A
N
Q
---------
23
PsiBlast_CBE
80.69
39%
-42
- C3 -
3ZOK
9
DHQS_ACTCH
D:
[17-360]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
-
D
L
L
Q
R
H
V
H
G
--
K
---
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
T
N
-
E
-------
N
----
P
NVS-----
V
E
--
S
V
I
-
L
---
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
-
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
---
N
F
---
F
E
W
Q
E
-
K
N
-
M
P
A
L
-----
M
A
R
-
D
--------------
P
S
A
---------
L
A
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
-
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
----
V
M
A
V
DMSYRLG
W
I
D
-
E
S
I
--
V
---------
N
R
-----
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
-
P
----------
E
-
T
M
---------
T
V
E
M
----------
F
K
S
V
M
A
V
D
K
K
V
-----
A
D
G
L
L
R
L
I
L
L
K
---
G
P
L
G
N
C
V
--
F
------
T
---------------------
50
HHSearch
80.63
39%
-28
- C3 -
5HVN
2
?
A:
[13-360]
-------
T
F
S
P
S
Y
N
I
I
V
D
S
V
L
----
D
F
S
H
I
L
E
---
Y
V
T
N
K
---
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
L
A
A
L
V
D
-
D
-------
L
----
D
--------
V
R
--
T
C
I
-
L
---
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
N
S
T
V
L
-
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
-
K
---
D
F
---
Y
L
-
W
L
-
D
S
N
R
D
K
I
-----
L
A
K
D
S
--------------
V
T
L
---------
I
-
E
M
---
V
K
R
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
Y
R
-
G
-
L
K
H
G
E
A
V
G
V
G
M
----
A
Q
A
I
-------
D
F
S
-
H
Y
L
--
G
L
I
-
S
Q
Q
Q
A
-
K
D
-----
F
N
D
F
I
V
S
F
G
I
S
I
D
F
-
P
----------
N
-
D
I
---------
C
Q
K
E
----------
F
L
E
A
M
L
L
D
---------
N
K
E
L
K
F
I
L
I
E
N
-
I
G
S
L
S
L
Q
K
--
Q
------
S
K
N
E
L
E
Q
F
L
D
I
-----------
24
PsiBlast_CBE
80.04
39%
-41
- C3 -
3ZOK
10
DHQS_ACTCH
C:
[17-360]
---
V
D
V
D
L
G
D
R
S
Y
P
I
Y
I
G
S
G
L
L
D
--
Q
P
-
D
L
L
Q
R
H
V
H
G
--
K
---
R
V
L
V
V
T
N
S
T
V
A
P
I
Y
L
D
K
V
V
G
A
L
T
N
-
E
-------
N
----
P
NVS-----
V
E
--
S
V
I
-
L
---
P
D
G
E
K
Y
K
N
M
D
T
L
M
K
V
F
D
K
A
I
E
S
R
--
L
D
R
R
-
C
T
F
-
V
A
L
G
G
G
V
I
G
D
M
C
G
Y
A
A
A
S
F
L
R
G
V
N
F
I
Q
I
P
T
T
V
M
A
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
R
L
G
K
N
L
I
G
A
F
Y
Q
P
Q
C
V
L
I
D
T
D
T
L
N
T
L
P
D
R
E
L
A
S
G
L
A
E
V
V
K
Y
G
L
I
R
D
A
---
N
F
---
F
E
W
Q
E
-
K
N
-
M
P
A
L
-----
M
A
R
-
D
--------------
P
S
A
---------
L
A
Y
A
---
I
K
R
S
C
E
N
K
A
E
V
V
S
L
D
E
K
E
S
G
L
R
A
T
L
N
L
G
H
T
F
G
H
A
I
E
T
G
F
G
-
Y
-
G
Q
W
L
H
G
E
A
V
A
A
G
M
----
V
M
A
V
DMSYRLG
W
I
D
-
E
S
I
--
V
---------
N
R
-----
A
H
N
I
L
Q
Q
A
K
L
P
T
A
P
-
P
----------
E
-
T
M
---------
T
V
E
M
----------
F
K
S
V
M
A
V
D
K
K
V
-----
A
D
G
L
L
R
L
I
L
L
K
---
G
P
L
G
N
C
V
--
F
------
T
---------------------
5
PsiBlast_PDB
79.41
40%
-49
- C3 -
5HVN
2
?
A:
[39-362]
-------------------------------------------
Q
V
L
V
V
T
N
T
T
V
A
K
L
Y
L
T
K
F
L
A
A
L
V
D
-
D
-------
L
----
D
--------
V
R
--
T
C
I
-
L
---
E
D
G
E
Q
Y
K
S
Q
Q
S
L
D
K
I
L
S
T
L
L
E
N
H
--
F
T
R
N
-
S
T
V
L
V
A
L
G
G
G
V
I
G
D
I
T
G
F
A
A
A
I
Y
Q
R
G
I
D
F
I
Q
I
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
A
I
N
H
Q
L
G
K
N
M
I
G
A
F
Y
Q
P
K
V
V
Y
T
S
I
E
F
Y
K
T
L
P
Q
R
E
Y
I
A
G
M
A
E
V
V
K
Y
A
F
I
S
K
D
---
F
Y
---
L
W
-
L
D
-
S
N
-
R
D
K
I
-----
L
A
K
-
D
--------------
S
V
T
---------
L
I
E
M
---
V
K
R
S
C
Q
I
K
A
Q
V
V
A
M
D
---
T
G
A
R
A
I
L
N
F
G
H
T
F
G
H
A
I
E
K
C
Q
N
-
Y
-
R
G
L
K
H
G
E
A
V
G
V
G
M
----
A
Q
A
I
-------
D
F
S
-
H
Y
L
--
G
L
I
-
S
-
Q
Q
Q
-
A
K
D
F
N
D
F
I
V
S
F
G
I
S
I
D
F
P
N
D
I
C
Q
----------
K
-
E
------------------------
F
L
E
A
M
L
L
D
---------
N
K
E
L
K
F
I
L
I
E
N
-
I
G
S
L
S
L
Q
K
--
Q
------
S
K
N
E
L
E
Q
F
L
D
I
S
R
---------
64
Fugue
77.05
30%
-68
- C3 -
1UJN
-
?
A:
[1-347]
M
Q
R
L
E
V
R
E
-
P
V
P
Y
P
I
L
V
G
E
G
V
L
K
--
E
--------
V
P
P
L
A
G
---
P
A
A
L
L
F
D
----
R
R
V
E
G
F
A
Q
E
V
A
K
A
-
L
-------
G
----
V
--------
R
H
--
L
L
G
-
L
---
P
G
G
E
A
A
K
S
L
E
V
Y
G
K
V
L
S
W
L
A
E
K
G
--
L
P
R
N
-
A
T
L
-
L
V
V
G
G
G
T
L
T
D
L
G
G
F
V
A
A
T
Y
L
R
G
V
A
Y
L
A
F
P
T
T
T
L
A
I
V
D
A
S
V
G
G
K
T
G
I
N
L
P
E
G
K
N
L
V
G
A
F
H
F
P
Q
G
V
Y
A
E
L
R
A
L
K
T
L
P
L
P
T
F
K
E
G
L
V
E
A
F
K
H
G
L
I
A
G
D
---
E
A
---
L
L
-
K
V
-
E
D
-
L
T
P
----------
Q
--------------
S
P
R
---------
L
E
A
F
---
L
A
R
A
V
A
V
K
V
R
V
T
E
E
D
P
L
E
K
G
K
R
R
L
L
N
L
G
H
T
L
G
H
A
L
E
A
Q
T
R
-
H
-
A
-
L
P
H
G
M
A
V
A
Y
G
L
----
L
Y
A
A
-------
L
L
G
-
R
A
L
---
G
G
-
E
-
D
L
L
-
P
P
-----
V
R
R
L
L
L
W
L
S
P
P
P
------------------------------------------
L
P
P
L
A
F
E
D
L
L
-----
P
Y
L
S
L
H
W
V
V
P
L
A
-
P
G
R
L
V
V
R
P
--
L
------
P
E
G
L
L
R
E
A
F
A
A
W
R
E
E
L
K
G
L
GLL
26
PsiBlast_CBE
76.87
38%
-28
- C3 -
5EKS
2
?
B:
[9-346]
M
Q
T
L
H
V
E
L
--
R
R
Y
P
I
F
I
G
S
Q
L
D
P
--
K
-------
Q
L
L
E
P
Y
I
HGQ
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
E
S
L
G
-------
K
----
T
--------
V
A
--
T
C
I
-
L
---
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
D
-
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
G
D
E
---
D
F
L
V
W
L
E
-
E
---
N
-
M
D
G
L
-----
V
A
R
-
D
--------------
A
D
L
---------
L
A
E
A
---
V
Y
R
S
C
A
H
K
A
R
I
V
A
N
D
E
----
E
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
-
Y
-
G
T
W
L
H
G
E
A
V
A
T
G
M
----
V
M
A
A
-------
D
L
S
-
Q
R
L
GW
I
S
N
-
E
--
D
V
-
A
R
-----
T
K
K
I
I
Q
R
A
N
L
P
I
S
C
------------
P
-
Q
I
---------
P
L
D
D
----------
F
L
G
Y
M
A
H
D
K
K
V
-------
G
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
------------------------------------
48
HHSearch
76.64
35%
-18
- C3 -
3QBE
3
AROB_MYCTU
A:
[19-366]
-------
A
V
D
P
P
Y
P
V
V
I
G
T
G
L
L
D
--
E
L
E
D
L
L
A
-----
D
R
H
---
K
V
A
V
V
H
Q
P
G
L
A
E
-
T
A
E
E
I
R
K
R
L
A
G
-
K
------------
G
--------
V
D
A
H
R
I
E
-
I
---
P
D
A
E
A
G
K
D
L
P
V
V
G
F
I
W
E
V
L
G
R
I
G
--
I
G
R
K
-
D
A
L
-
V
S
L
G
G
G
A
A
T
D
V
A
G
F
A
A
A
T
W
L
R
G
V
S
I
V
H
L
P
T
T
L
L
G
M
V
D
A
A
V
G
G
K
T
G
I
N
T
D
A
G
K
N
L
V
G
A
F
H
Q
P
L
A
V
L
V
D
L
A
T
L
Q
T
L
P
R
D
E
M
I
C
G
M
A
E
V
V
K
A
G
F
I
A
D
P
---
V
I
---
L
D
-
L
I
-
E
A
D
P
Q
A
A
-----
L
D
P
-
A
--------------
G
D
V
---------
L
P
E
L
---
I
R
R
A
I
T
V
K
A
E
V
V
A
A
----
S
E
L
R
E
I
L
N
Y
G
H
T
L
G
H
A
I
E
R
R
E
R
-
Y
-
R
-
W
R
H
G
A
A
V
S
V
G
L
----
V
F
A
A
-------
E
L
A
-
R
L
A
--
G
R
L
-
D
D
A
T
A
-
Q
R
-----
H
R
T
I
L
S
S
L
G
L
P
V
S
Y
-
D
----------
P
--
D
---------
A
L
P
Q
----------
L
L
E
I
M
A
G
D
K
K
T
-----
R
A
G
V
L
R
F
V
V
L
D
G
-
L
A
K
P
G
R
M
V
--
G
P-----
D
P
G
L
L
V
T
A
Y
A
G
V
C
---------
40
HHSearch
76.16
36%
-35
- C3 -
1XAH
2
AROB_STAAR
A:
[2-352]
--
K
L
Q
T
T
Y
P
S
N
N
Y
P
I
Y
V
E
H
G
A
I
K
--
Y
I
G
T
Y
L
N
Q
-----
F
D
---
Q
S
F
L
L
I
D
E
Y
V
N
Q
Y
F
A
N
K
F
D
-------------------
N
--------
V
H
--
K
V
I
-
I
---
P
A
G
E
K
T
K
T
F
E
Q
Y
Q
E
T
L
E
Y
I
L
S
H
H
--
V
T
R
N
-
T
A
I
-
I
A
V
G
G
G
A
T
G
D
F
A
G
F
V
A
A
T
L
L
R
G
V
H
F
I
Q
V
P
T
T
I
L
A
H
-
D
S
S
V
G
G
K
V
G
I
N
S
K
Q
G
K
N
L
I
G
A
F
Y
R
P
T
A
V
I
Y
D
L
D
F
L
K
T
L
P
F
K
Q
I
L
S
G
Y
A
E
V
Y
K
H
A
L
L
N
G
E
---
S
A
---
T
Q
-
D
I
-
E
Q
H
F
K
D
R
-----
E
I
L
Q
S
--------------
L
N
G
---------
M
D
K
Y
---
I
A
K
G
I
E
T
K
L
D
I
V
V
A
D
E
K
E
Q
G
V
R
K
F
L
N
L
G
H
T
F
G
H
A
V
E
Y
Y
---
H
-
K
-
I
P
H
G
H
A
V
M
V
G
I
----
I
Y
Q
F
-------
I
V
A
-
N
A
L
--
F
D
S
-
K
-
H
D
I
-
S
H
-----
Y
I
Q
Y
L
I
Q
L
G
Y
P
L
D
-----------------------------------------------------------
G
V
Q
M
V
L
M
R
Q
-
F
G
D
I
V
V
Q
H
--
V
------
D
Q
L
T
L
Q
H
A
C
E
Q
L
K
T
Y
-------
42
HHSearch
74.96
28%
-38
- C3 -
2GRU
8
DOIS_BACCI
A:
[2-366]
-
T
T
K
Q
I
C
F
A
D
R
C
F
N
F
A
F
G
E
H
V
L
E
--
S
V
E
S
Y
I
P
R
---
D
E
F
D
---
Q
Y
I
M
I
S
D
S
G
V
P
D
S
I
V
H
Y
A
A
E
Y
F
G
K
-
L
-------
A
----
P
--------
V
H
--
I
L
R
-
F
---
Q
G
G
E
E
Y
K
T
L
S
T
V
T
N
L
Q
E
R
A
I
A
L
G
--
A
N
R
R
-
T
A
I
-
V
A
V
G
G
G
L
T
G
N
V
A
G
V
A
A
G
M
M
F
R
G
I
A
L
I
H
V
P
T
T
F
L
A
A
S
D
S
V
L
S
I
K
Q
A
V
N
L
T
S
G
K
N
L
V
G
F
Y
Y
P
P
R
F
V
F
A
D
T
R
I
L
S
E
S
P
P
R
Q
V
K
A
G
M
C
E
L
V
K
N
M
L
I
L
E
N
---
D
N
---
K
E
-
F
T
-
E
D
D
L
N
S
A
-----
N
V
Y
-
S
--------------
P
K
Q
---------
L
E
T
F
---
I
N
F
C
I
S
A
K
M
S
V
L
S
E
D
I
Y
E
K
K
K
G
L
I
F
E
Y
G
H
T
I
G
H
A
I
E
L
A
E
Q
-
G
-
G
-
I
T
H
G
E
A
I
A
V
G
M
----
I
Y
A
A
-------
K
I
A
-
N
R
M
--
N
L
M
-
P
E
H
D
V
-
S
A
-----
H
Y
W
L
L
N
K
I
G
A
L
Q
D
I
-
P
----------
L
-
K
S
---------
D
P
D
S
----------
I
F
H
Y
L
I
H
D
N
K
R
GYIKL
D
E
D
N
L
G
M
I
L
L
S
G
-
V
G
K
P
A
M
Y
N
--
Q
TL
L
T
P
V
R
K
T
L
I
K
E
V
I
R
E
-----------
6
PsiBlast_PDB
74.47
38%
-24
- C3 -
5EKS
2
?
A:
[9-346]
M
Q
T
L
H
V
E
L
G
E
R
R
Y
P
I
F
I
G
S
Q
L
D
P
--
K
-------
Q
L
L
E
P
Y
I
HGQ
Q
V
M
I
V
S
N
V
T
V
A
P
L
Y
L
S
H
Y
Q
E
A
L
E
S
L
G
-------
K
----
T
--------
V
A
--
T
C
I
-
L
---
P
D
G
E
K
Y
K
D
I
Q
H
L
N
L
I
F
D
A
L
L
E
A
G
--
F
N
R
D
-
C
T
V
-
L
A
L
G
G
G
V
I
G
D
M
A
G
F
A
S
A
C
F
Q
R
G
V
Y
F
V
Q
V
P
T
T
L
L
S
Q
V
D
S
S
V
G
G
K
T
G
I
N
H
P
L
G
K
N
M
L
G
A
F
Q
Q
P
Q
V
V
L
A
D
M
A
Q
L
N
T
L
P
E
R
E
L
S
A
G
L
A
E
V
I
K
Y
A
L
L
G
D
E
---
D
F
L
V
W
L
E
-
E
---
N
-
M
D
G
L
-----
V
A
R
-
D
--------------
A
D
L
---------
L
A
E
A
---
V
Y
R
S
C
A
H
K
A
R
I
V
A
N
D
E
K
---
E
R
A
L
L
N
L
G
H
T
F
G
H
A
I
E
S
Y
L
G
-
Y
-
G
T
W
L
H
G
E
A
V
A
T
G
M
----
V
M
A
A
-------
D
L
S
-
Q
R
L
GW
I
S
N
-
E
--
D
V
-
A
R
-----
T
K
K
I
I
Q
R
A
N
L
P
I
S
C
------------
P
-
Q
I
---------
P
L
D
D
----------
F
L
G
Y
M
A
H
D
K
K
V
--------
Q
L
R
L
V
L
L
K
Q
-
L
G
Q
------------------------------------
47
HHSearch
69.06
33%
-11
- C3 -
1SG6
2
ARO1_EMENI
A:
[9-391]
--------
I
L
G
R
E
S
I
I
A
D
F
G
L
W
R
NY
V
A
K
D
L
I
S
D
---
C
S
S
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
------------
A
A
EITP
S
P
R
L
L
--
I
Y
N
-
R
---
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
---
E
E
---
F
T
-
A
L
-
E
E
N
A
E
T
I
-----
L
K
A
-
V
R
R
E
V
T
PGEHRFEGT
E
E
I
---------
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-----
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
-
P
-
Q
-
I
L
H
G
E
C
V
A
I
G
M
----
V
K
E
A
-------
E
L
A
-
R
H
L
--
G
I
L
-
K
G
V
A
V
-
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
----------
D
A
R
I
R
K
L
T
AGKHC
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
------------
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
R
A
S
V
V
-----
A
N
E
D
I
R
V
V
L
-------------
63
Fugue
68.20
32%
-7
- C3 -
1DQS
5
ARO1_EMENI
A:
[4-391]
---
P
T
K
I
S
I
L
G
R
E
S
I
I
A
D
F
G
L
W
R
--
N
Y
-
V
A
K
D
L
I
S
D
C
S
S
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
A
A
EITP
S
P
----
R
--------
L
L
--
I
Y
N
-
R
---
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
---
E
E
---
F
T
-
A
L
E
E
N
-
A
E
T
I
-----
L
K
A
-
V
R
RRFEGT-------
E
E
I
---------
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
T
-
P
--
Q
I
L
H
G
E
C
V
A
I
G
M
----
V
K
E
A
-------
E
L
A
-
R
H
L
--
G
I
L
K
G
-
V
A
V
-
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
----------
D
-
A
R
---------
I
R
K
L
TAGKHCS
V
D
Q
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
T
P
Y
E
T
R
--
A
------
S
V
V
A
N
E
D
I
R
V
V
L
----------
15
PsiBlast_PDB
63.53
34%
-8
- C3 -
1NVD
4
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
IT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-------------------RFEGT
E
E
I
-
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
A
G
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
30
PsiBlast_CBE
63.38
34%
-8
- C3 -
1NVF
5
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
AEIT
P
--------
S
P
--
R
L
L
-
I
YNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
EEF
T
A
---
L
E
-
E
---
N
-
A
E
T
I
LKAVR
R
E
V
-
T
--------------
P
G
E
HRFEGTEEI
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
VKEA
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
DARIRKLTAG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
37
PsiBlast_CBE
62.95
34%
-8
- C3 -
1NR5
5
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
I
T
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
33
PsiBlast_CBE
62.66
34%
-11
- C3 -
1NVB
2
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
AEIT
P
--------
S
P
--
R
L
L
-
I
YNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
EEF
T
A
---
L
E
-
E
---
N
-
A
E
T
I
LKAVR
R
E
V
-
T
--------------
P
G
E
HRFEGTEEI
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
VKEA
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
DARIRKLTAG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
32
PsiBlast_CBE
62.64
34%
-8
- C3 -
1NVD
4
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
EIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R----------------------RFEGT
E
E
I
-
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
10
PsiBlast_PDB
62.60
34%
-9
- C3 -
1NR5
4
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
IT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
14
PsiBlast_PDB
62.45
34%
-10
- C3 -
1NVB
5
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
I
T
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
17
PsiBlast_PDB
62.42
34%
-14
- C3 -
1SG6
2
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
EIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
-----
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
------------
I
V
L
L
S
A
-
I
G
-------------------------------------
9
PsiBlast_PDB
62.30
34%
-8
- C3 -
1DQS
5
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
EIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
---------------------RFEGT
E
E
I
-
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
TAG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
29
PsiBlast_CBE
62.04
34%
-7
- C3 -
1NVF
5
ARO1_EMENI
C:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
AEIT
P
--------
S
P
--
R
L
L
-
I
YNR
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
EEF
T
A
---
L
E
-
E
---
N
-
A
E
T
I
LKAVR
R
E
V
-
T
--------------
P
G
E
HRFEGTEEI
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
VKEA
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
DARIRKLTAG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
34
PsiBlast_CBE
61.39
34%
-8
- C3 -
1NVA
3
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
I
T
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
A
G
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
--------
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
28
PsiBlast_CBE
61.14
34%
-18
- C3 -
1SG6
2
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
I
T
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
-------------
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
38
PsiBlast_CBE
61.05
34%
-8
- C3 -
1DQS
5
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
EIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
---------------------T
E
E
I
-----
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
16
PsiBlast_PDB
60.72
34%
-5
- C3 -
1NVF
5
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
EIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
E
R
E
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
A
G
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
K
K
N
-----
D
G
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
36
PsiBlast_CBE
60.47
34%
-9
- C3 -
1NRX
7
ARO1_EMENI
B:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
AEIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
13
PsiBlast_PDB
59.72
34%
-11
- C3 -
1NVA
3
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
A
E
I
T
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
E
HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
----
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
A
G
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------
11
PsiBlast_PDB
59.12
34%
-11
- C3 -
1NRX
7
ARO1_EMENI
A:
[37-372]
---------------------------------------
T
---
T
Y
V
L
V
T
D
T
N
I
G
S
I
Y
T
P
S
F
E
E
A
F
R
K
-
R
-------
A
AEIT
P
--------
S
P
--
R
L
L
-
I
Y
N
R
P
P
G
E
V
S
K
S
R
Q
T
K
A
D
I
E
D
W
M
L
S
Q
N
PP
C
G
R
D
-
T
V
V
-
I
A
L
G
G
G
V
I
G
D
L
T
G
F
V
A
S
T
Y
M
R
G
V
R
Y
V
Q
V
P
T
T
L
L
A
M
V
D
S
S
I
G
G
K
T
A
I
D
T
P
L
G
K
N
L
I
G
A
I
W
Q
P
T
K
I
Y
I
D
L
E
F
L
E
T
L
P
V
R
E
F
I
N
G
M
A
E
V
I
K
T
A
A
I
S
S
E
E
E
F
T
A
---
L
E
-
E
---
N
-
A
E
T
I
L
K
A
V
R
R
E
V
-
T
--------------
P
G
-HRFEGT
E
E
I
L
K
A
R
---
I
L
A
S
A
R
H
K
A
Y
V
V
S
A
D
---
G
G
L
R
N
L
L
N
W
G
H
S
I
G
H
A
I
E
A
I
L
--
T
-
P
Q
I
L
H
G
E
C
V
A
I
G
M
V
K
E
A
E
L
A
R
-------
H
L
G
I
L
K
G
--
V
A
V
-------
S
R
-----
I
V
K
C
L
A
A
Y
G
L
P
T
S
L
-
K
D
A
R
I
R
K
L
T
AG
K
-
H
C
---------
S
V
D
Q
----------
L
M
F
N
M
A
L
D
----------
P
K
K
K
I
V
L
L
S
A
-
I
G
-------------------------------------