@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29050: (2016-07-16 )
MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAEIKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF
Atome Classification :
(91 SA)
.........10........20...-----....-.--30.---..-.....40..-......50........60........70-........80........90........100.......110......------------------.--------------------120--------------.---------------.-------.---------------.--------------------....130.......140.......150.......--160--.......170.......180.......190...----.----------..----------.----------200---------.-------.---.......210.......220.......230.......240.......250.......260....-.---..270---.........280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTT
H
L
Q
A
K
A
TLHNGVEM
P
W
F
G
L
G
V
-----
F
Q
VE-E--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-GYRSI
D
T
A
A
I
YGNEAG
V
G
E
G
I
R
E
G
I
E
E
A-GISRE
D
L
F
I
T
S
KVWNADL
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
HWP------------------V--------------------EG---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
KEG
R
I
K
A
I
GVSN
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
QVEFHPRL
T
Q
K
E
L
I
R
Y
C
Q
NQG
I
Q
MEAWS
P
----
L
----------MQ----------G----------Q-----------L-------L---D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
RWDLQHG
I
I
TIPKST
K
E
H
RIKENA
S
V
F
D
F
EL
T
Q
D
D
M
N
R
I
D
A
LN-E---NLR-----VGPDPDNFDF
22
PsiBlast_CBE
98.12
100%
-96
- C5 -
3B3D
1
YTBE_BACSU
B:
[38-314]
---
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
21
PsiBlast_CBE
97.45
100%
-90
- C5 -
3B3D
1
YTBE_BACSU
C:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
101
HHSearch
96.33
100%
-89
- C5 -
3B3D
1
YTBE_BACSU
A:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
1
PsiBlast_PDB
96.33
100%
-89
- C5 -
3B3D
1
YTBE_BACSU
A:
[35-314]
M
T
T
H
L
Q
A
K
A
T
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
Q
V
E
-
E
--
G
S
E
---
L
V
-
N
A
V
K
T
A
I
V
H
-
G
Y
R
S
I
D
T
A
A
I
Y
G
N
E
A
G
V
G
E
G
I
R
E
G
I
E
E
A
-
G
I
S
R
E
D
L
F
I
T
S
K
V
W
N
A
D
L
G
Y
E
E
T
L
A
A
F
E
T
S
L
S
K
L
G
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
V
--------------------
E
G
---------------
K
---------------
Y
-------
K
---------------
E
--------------------
A
W
R
A
L
E
T
L
Y
K
E
G
R
I
K
A
I
G
V
S
N
F
Q
I
H
H
L
E
D
L
M
T
A
A
--
E
I
K
--
P
M
I
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
I
R
Y
C
Q
N
Q
G
I
Q
M
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
H
P
V
L
A
D
I
A
Q
T
Y
N
K
S
V
A
Q
I
I
L
R
W
D
L
Q
H
G
I
I
T
I
P
K
S
T
K
E
H
R
I
K
E
N
A
S
V
F
D
F
E
L
T
Q
D
D
M
N
R
I
D
A
L
N
-
E
---
N
L
R
-----
V
G
P
D
P
D
N
F
D
F
104
HHSearch
86.06
72%
-78
- C5 -
3F7J
8
GR_BACSU
A:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
2
PsiBlast_PDB
85.85
71%
-78
- C5 -
3F7J
8
GR_BACSU
A:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
24
PsiBlast_CBE
85.65
71%
-84
- C5 -
3D3F
1
GR_BACSU
B:
[2-275]
--
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
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Q
I
A
E
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N
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A
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W
D
L
Q
H
G
V
V
T
I
P
K
S
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E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
3
PsiBlast_PDB
85.32
71%
-78
- C5 -
3D3F
1
GR_BACSU
A:
[2-275]
--
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
23
PsiBlast_CBE
85.28
71%
-79
- C5 -
3F7J
7
GR_BACSU
B:
[1-276]
M
P
T
S
L
K
D
T
V
K
L
H
N
G
V
E
M
P
W
F
G
L
G
V
-----
F
K
V
E
-
N
--
G
N
E
---
A
T
-
E
S
V
K
A
A
I
K
N
-
G
Y
R
S
I
D
T
A
A
I
Y
K
N
E
E
G
V
G
I
G
I
K
E
----
S
-
G
V
A
R
E
E
L
F
I
T
S
K
V
W
N
E
D
Q
G
Y
E
T
T
L
A
A
F
E
K
S
L
E
R
L
Q
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
Y
-------
K
---------------
D
--------------------
T
W
R
A
L
E
K
L
Y
K
D
G
K
I
R
A
I
G
V
S
N
F
Q
V
H
H
L
E
E
L
L
K
D
A
--
E
I
K
--
P
M
V
N
Q
V
E
F
H
P
R
L
T
Q
K
E
L
R
D
Y
C
K
G
Q
G
I
Q
L
E
A
W
S
P
----
L
----------
M
Q
----------
G
----------
Q
-----------
L
-------
L
---
D
N
E
V
L
T
Q
I
A
E
K
H
N
K
S
V
A
Q
V
I
L
R
W
D
L
Q
H
G
V
V
T
I
P
K
S
I
K
E
H
R
I
I
E
N
A
D
I
F
D
F
E
L
S
Q
E
D
M
D
K
I
D
A
L
N
-
K
---
D
E
R
-----
V
G
P
N
P
D
E
L
L
F
27
PsiBlast_CBE
84.39
55%
-92
- C5 -
4FZI
2
PGFS_TRYCC
B:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
---------------------------------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
102
HHSearch
81.04
51%
-96
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[10-277]
------
Q
S
L
K
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
A
S
----
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
8
PsiBlast_PDB
80.48
51%
-96
- C5 -
1VBJ
2
PGFS_TRYBB
A:
[14-277]
----------
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
S
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
28
PsiBlast_CBE
79.72
51%
-92
- C5 -
1VBJ
2
PGFS_TRYBB
B:
[14-277]
----------
L
S
N
G
V
M
M
P
V
L
G
F
G
M
-----
W
K
L
Q
-
D
--
G
N
E
---
A
E
-
T
A
T
M
W
A
I
K
S
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
A
G
R
A
I
----
A
S
C
-
G
V
P
R
E
E
L
F
V
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
S
A
F
E
K
S
I
K
K
L
G
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
D
---------------
K
---------------
F
-------
I
---------------
D
--------------------
T
W
K
A
F
E
K
L
Y
A
D
K
K
V
R
A
I
G
V
S
N
F
H
E
H
H
I
E
E
L
L
K
H
C
--
K
V
A
--
P
M
V
N
Q
I
E
L
H
P
L
L
N
Q
K
A
L
C
E
Y
C
K
S
K
N
I
A
V
T
A
W
S
P
----
L
----------
G
Q
----------
G
----------
H
-----------
L
-------
V
---
E
D
A
R
L
K
A
I
G
G
K
Y
G
K
T
A
A
Q
V
M
L
R
W
E
I
Q
A
G
V
I
T
I
P
K
S
G
N
E
A
R
I
K
E
N
G
N
I
F
D
F
E
L
T
A
E
D
I
Q
V
I
D
G
M
N
-
A
---
G
H
R
-----
Y
G
P
D
P
E
V
F
--
105
HHSearch
79.63
56%
-58
- C5 -
4GIE
2
PGFS_TRYCC
A:
[15-284]
-------
C
V
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
-----------
E
-------
A
GIL
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
7
PsiBlast_PDB
79.31
55%
-56
- C5 -
4GIE
2
PGFS_TRYCC
A:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
EAG--------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
6
PsiBlast_PDB
78.80
55%
-58
- C5 -
4FZI
1
PGFS_TRYCC
A:
[17-284]
---------
T
L
H
N
S
V
R
M
P
Q
L
G
L
G
V
-----
W
R
A
Q
-
D
--
G
A
E
---
T
A
-
N
A
V
R
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
Y
I
Y
S
N
E
R
G
V
G
Q
G
I
R
E
----
S
-
G
V
P
R
E
E
V
W
V
T
T
K
V
W
N
S
D
Q
G
Y
E
K
T
L
A
A
F
E
R
S
R
E
L
L
G
L
E
Y
I
D
L
Y
L
I
H
W
P
------------------
G
--------------------
K
K
---------------
K
---------------
F
-------
V
---------------
D
--------------------
T
W
K
A
L
E
K
L
Y
E
E
K
K
V
R
A
I
G
V
S
N
F
E
P
H
H
L
T
E
L
F
K
S
C
--
K
I
R
--
P
M
V
N
Q
V
E
L
H
P
L
F
Q
Q
R
T
L
R
E
F
C
K
Q
H
N
I
A
I
T
A
W
S
P
----
L
----------
G
S
----------
G
----------
E
EAG--------
I
-------
L
---
K
N
H
V
L
G
E
I
A
K
K
H
N
K
S
P
A
Q
V
V
I
R
W
D
I
Q
H
G
I
V
T
I
P
K
S
T
N
K
G
R
I
Q
E
N
F
N
V
W
D
F
K
L
T
E
E
E
M
R
Q
I
D
E
L
N
-
E
---
D
K
R
-----
I
G
A
D
P
D
N
F
--
26
PsiBlast_CBE
73.53
56%
-20
- C5 -
4F40
10
PGFS_LEIMA
B:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RGKDILS-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
25
PsiBlast_CBE
73.50
56%
-11
- C5 -
4G5D
1
PGFS_LEIMA
B:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
115
HHSearch
73.44
47%
-59
- C5 -
4MHB
8
?
A:
[15-273]
-----
M
Q
T
V
K
L
N
N
G
I
A
M
P
L
L
G
F
G
V
-----
F
Q
M
T
-
N
--
T
A
E
---
C
E
-
R
A
V
I
D
A
I
E
T
-
G
Y
R
L
I
D
T
A
A
S
Y
Q
N
E
T
Q
V
G
N
A
L
K
L
----
S
-
G
I
A
R
D
E
L
F
I
T
T
K
L
W
L
Q
D
T
Y
Y
E
G
A
K
A
Q
F
E
R
S
L
N
R
L
Q
L
D
Y
V
D
L
Y
L
I
H
Q
P
------------------
Y
--------------------
G
----------------
D
---------------
V
-------
H
---------------
G
--------------------
A
W
R
A
M
E
E
L
H
Q
A
G
K
I
R
A
I
G
V
S
N
F
H
P
D
R
L
A
D
L
M
A
F
N
--
K
I
I
--
P
A
V
N
Q
I
E
V
N
P
F
N
Q
Q
L
H
A
V
P
W
M
Q
S
R
G
I
Q
P
E
A
W
A
P
----
F
----------
A
E
----------
G
----------
R
NG---------
L
-------
F
---
Q
N
P
V
L
T
A
I
G
E
K
Y
G
K
S
V
G
Q
V
V
L
R
W
I
F
Q
R
G
I
V
S
L
A
K
S
V
R
K
G
R
M
E
E
N
I
N
I
L
D
F
E
L
S
A
E
D
M
L
Q
I
A
A
L
D
-
T
---------------------
4
PsiBlast_PDB
73.39
56%
-20
- C5 -
4F40
11
PGFS_LEIMA
A:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
106
HHSearch
73.34
58%
-22
- C5 -
4F40
11
PGFS_LEIMA
A:
[13-285]
--------
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
------------------
R
--------------------
G
K
D
I
L
S
K
EGK-------
K
---------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
---
5
PsiBlast_PDB
72.69
56%
-12
- C5 -
4G5D
1
PGFS_LEIMA
A:
[10-288]
-----
K
A
M
V
T
L
S
N
G
V
K
M
P
Q
F
G
L
G
V
-----
W
Q
S
P
-
A
--
G
E
V
---
T
E
-
N
A
V
K
W
A
L
C
A
-
G
Y
R
H
I
D
T
A
A
I
Y
K
N
E
E
S
V
G
A
G
L
R
A
----
S
-
G
V
P
R
E
D
V
F
I
T
T
K
L
W
N
T
E
Q
G
Y
E
S
T
L
A
A
F
E
E
S
R
Q
K
L
G
V
D
Y
I
D
L
Y
L
I
H
W
P
RG
K
D
I
L
S
-----------
K
--------------------
E
G
---------------
K
K--------------
Y
-------
L
---------------
D
--------------------
S
W
R
A
F
E
Q
L
Y
K
E
K
K
V
R
A
I
G
V
S
N
F
H
I
H
H
L
E
D
V
L
A
M
C
--
T
V
T
--
P
M
V
N
Q
V
E
L
H
P
L
N
N
Q
A
D
L
R
A
F
C
D
A
K
Q
I
K
V
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------
K
-----------
L
-------
L
---
S
N
P
I
L
S
A
I
G
A
K
Y
N
K
T
A
A
Q
V
I
L
R
W
N
I
Q
K
N
L
I
T
I
P
K
S
V
H
R
E
R
I
E
E
N
A
D
I
F
D
F
E
L
G
A
E
D
V
M
S
I
D
A
L
N
-
T
---
N
S
R
-----
Y
G
P
D
P
D
E
A
Q
F
16
PsiBlast_PDB
68.77
41%
-18
- C5 -
3H4G
3
AK1A1_PIG
A:
[8-301]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
E
RGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
IRYDATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
117
HHSearch
68.72
40%
-36
- C5 -
3H7U
2
AKRC9_ARATH
A:
[24-307]
----
A
I
T
F
F
K
L
N
T
G
A
K
F
P
S
V
G
L
G
T
-----
W
Q
A
S
-
P
---
G
L
---
V
G
-
D
A
V
A
A
A
V
K
I
-
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
E
D
R
-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
--------------------
R
I
K
K
GSVGIKPENLLPV
D
---------------
I
-------
P
---------------
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
----
L
----------
G
S
----------
P
----------
G
-----------
T
TWLKSDV
L
---
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
P
D
Y
M
F
A
K
F
A
E
I
E
-
Q
---------------------
17
PsiBlast_PDB
68.60
41%
-16
- C5 -
3FX4
5
AK1A1_PIG
A:
[8-297]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
I
R
Y
D
ATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
54
PsiBlast_CBE
68.25
41%
-34
- C5 -
4GAB
3
AK1BA_HUMAN
A:
[7-297]
----------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
----------
G
S
----------
P
DRPWAKPEDP
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
55
PsiBlast_CBE
68.19
41%
-36
- C5 -
4GA8
2
AK1BA_HUMAN
A:
[7-297]
----------
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
----------
G
S
----------
P
DRPWAKPEDP
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
49
PsiBlast_CBE
68.07
40%
-35
- C5 -
4JII
3
AK1BA_HUMAN
X:
[1-299]
--
S
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
29
PsiBlast_CBE
67.99
52%
-15
- C5 -
1VP5
1
?
B:
[17-276]
-------
K
V
T
L
N
N
G
V
E
M
P
I
L
G
Y
G
V
-----
F
Q
I
P
P
E
--
K
T
E
------
E
C
V
Y
E
A
I
K
V
-
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
D
E
G
-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
---------------------
G
---------------
D
---------------
V
-------
H
---------------
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
--
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
----
F
----------
A
E
----------
G
----------
R
KN---------
I
-------
F
---
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-
E
---------------------
12
PsiBlast_PDB
67.96
47%
-20
- C5 -
1MZR
4
DKGA_ECOLI
A:
[30-294]
----------
L
Q
D
G
N
V
M
P
Q
L
G
L
G
V
-----
W
Q
A
S
----
N
E
E
---
V
I
-
T
A
I
Q
K
A
L
E
V
-
G
Y
R
S
I
D
T
A
A
A
Y
K
N
E
E
G
V
G
K
A
L
K
N
----
A
-
S
V
N
R
E
E
L
F
I
T
T
K
L
W
N
D
D
--
H
K
R
P
R
E
A
L
L
D
S
L
K
K
L
Q
L
D
Y
I
D
L
Y
L
M
H
W
P
------------------
V
--------------------
P
A
ID-------------
H
---------------
Y
-------
V
---------------
E
--------------------
A
W
K
G
M
I
E
L
Q
K
E
G
L
I
K
S
I
G
V
C
N
F
Q
I
H
H
L
Q
R
L
I
D
E
T
--
G
V
T
--
P
V
I
N
Q
I
E
L
H
P
L
M
Q
Q
R
Q
L
H
A
W
N
A
T
H
K
I
Q
T
E
S
W
S
P
----
L
----------
A
Q
----------
G
GK--------
G
-----------
V
-------
F
---
D
Q
K
V
I
R
D
L
A
D
K
Y
G
K
T
P
A
Q
I
V
I
R
W
H
L
D
S
G
L
V
V
I
P
K
S
V
T
P
S
R
I
A
E
N
F
D
V
W
D
F
R
L
D
K
D
E
L
G
E
I
A
K
L
D
-
Q
---
G
K
R
-----
L
G
P
D
P
D
Q
F
--
48
PsiBlast_CBE
67.89
40%
-37
- C5 -
4JIH
2
AK1BA_HUMAN
A:
[1-299]
--
S
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
15
PsiBlast_PDB
67.75
41%
-15
- C5 -
3CV7
5
AK1A1_PIG
A:
[8-300]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
Q
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
I
R
Y
D
ATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
53
PsiBlast_CBE
67.65
40%
-35
- C5 -
1ZUA
2
AK1BA_HUMAN
X:
[1-298]
---
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDLFPKDDKGNA
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
44
PsiBlast_CBE
67.53
39%
-16
- C5 -
4GAC
2
AK1A1_MOUSE
A:
[7-296]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
H
A
L
S
A
-
G
Y
R
H
I
D
C
A
S
V
Y
G
N
E
T
E
I
G
E
A
L
K
E
S
V
G
S
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
------------------
Y
A
F
ERGDNPFPKNADG
T
V
R
Y
D
S
T
---------------
H
---------------
Y
-------
K
---------------
E
--------------------
T
W
K
A
L
E
V
L
V
A
K
G
L
V
K
A
L
G
L
S
N
F
N
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
H
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRHPDEPV-
L
-------
L
---
E
E
P
V
V
L
A
L
A
E
K
H
G
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
I
N
P
S
R
I
L
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
W
R
---------------
50
PsiBlast_CBE
67.44
40%
-36
- C5 -
4GQG
1
AK1BA_HUMAN
A:
[1-299]
--
S
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
QGFKSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
9
PsiBlast_PDB
67.29
52%
-15
- C5 -
1VP5
1
?
A:
[17-276]
-------
K
V
T
L
N
N
G
V
E
M
P
I
L
G
Y
G
V
-----
F
Q
I
P
P
E
--
K
T
E
------
E
C
V
Y
E
A
I
K
V
-
G
Y
R
L
I
D
T
A
A
S
Y
M
N
E
E
G
V
G
R
A
I
K
R
A
I
D
E
G
-
I
V
R
R
E
E
L
F
V
T
T
K
L
W
V
S
D
V
G
Y
E
S
T
K
K
A
F
E
K
S
L
K
K
L
Q
L
E
Y
I
D
L
Y
L
I
H
Q
P
------------------
F
---------------------
G
---------------
D
---------------
V
-------
H
---------------
C
--------------------
A
W
K
A
M
E
E
M
Y
K
D
G
L
V
R
A
I
G
V
S
N
F
Y
P
D
R
L
M
D
L
M
V
H
H
--
E
I
V
--
P
A
V
N
Q
I
E
I
H
P
F
Y
Q
R
Q
E
E
I
E
F
M
R
N
Y
N
I
Q
P
E
A
W
G
P
----
F
----------
A
E
----------
G
----------
R
KN---------
I
-------
F
---
Q
N
G
V
L
R
S
I
A
E
K
Y
G
K
T
V
A
Q
V
I
L
R
W
L
T
Q
K
G
I
V
A
I
P
K
T
V
R
R
E
R
M
K
E
N
I
S
I
F
D
F
E
L
T
Q
E
D
M
E
K
I
A
T
L
D
-
E
---------------------
52
PsiBlast_CBE
67.23
40%
-35
- C5 -
4I5X
2
AK1BA_HUMAN
A:
[1-299]
--
A
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDLFPKDDKG
N
A
I
--------------------
G
G
---------------
K
AT-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
51
PsiBlast_CBE
67.16
40%
-39
- C5 -
4GQ0
2
AK1BA_HUMAN (first)
A:
[1-299]
--
S
H
M
A
T
F
V
E
L
S
T
K
A
K
M
P
I
V
G
L
G
T
-----
W
K
S
P
-
L
--
G
-
K
---
V
K
-
E
A
V
K
V
A
I
D
A
-
G
Y
R
H
I
D
C
A
Y
V
Y
Q
N
E
H
E
V
G
E
A
I
Q
E
K
I
Q
E
K
-
A
V
K
R
E
D
L
F
I
V
S
K
L
W
P
T
F
F
E
R
P
L
V
R
K
A
F
E
K
T
L
K
D
L
K
L
S
Y
L
D
V
Y
L
I
H
W
P
Q
G
F
KSGDDL
F
P
K
D
DKG
N
A
I
--------------------
G
G
---------------
K
A
T-------------
F
-------
L
---------------
D
--------------------
A
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
L
G
V
S
N
F
S
H
F
Q
I
E
K
L
L
N
K
P
GL
K
Y
K
--
P
V
T
N
Q
V
E
C
H
P
Y
L
T
Q
E
K
L
I
Q
Y
C
H
S
K
G
I
T
V
T
A
Y
S
P
----
L
GSPDRPWAKP
E
D
----------
P
----------
S
-----------
L
-------
L
---
E
D
P
K
I
K
E
I
A
A
K
H
K
K
T
A
A
Q
V
L
I
R
F
H
I
Q
R
N
V
I
V
I
P
K
S
V
T
P
A
R
I
V
E
N
I
Q
V
F
D
F
K
L
S
D
E
E
M
A
T
I
L
S
F
N
-
R
---
N
W
R
---------------
63
PsiBlast_CBE
66.35
40%
-12
- C5 -
1A80
1
DKGA_CORSC
A:
[6-277]
---------
V
L
N
D
G
N
S
I
P
Q
L
G
Y
G
V
-----
F
K
V
P
-
P
---
A
D
---
T
Q
-
R
A
V
E
E
A
L
E
V
-
G
Y
R
H
I
D
T
A
A
I
Y
G
N
E
----
E
G
V
G
A
A
I
A
A
S
-
G
I
A
R
D
D
L
F
I
T
T
K
L
W
N
D
R
H
D
G
D
E
P
A
A
A
I
A
E
S
L
A
K
L
A
L
D
Q
V
D
L
Y
L
V
H
W
P
------------------
T
--------------------
P
A
AD-------------
N
---------------
Y
-------
V
---------------
H
--------------------
A
W
E
K
M
I
E
L
R
A
A
G
L
T
R
S
I
G
V
S
N
H
L
V
P
H
L
E
R
I
V
A
A
T
--
G
V
V
--
P
A
V
N
Q
I
E
L
H
P
A
Y
Q
Q
R
E
I
T
D
W
A
A
A
H
D
V
K
I
E
S
W
G
P
----
L
----------
G
Q
----------
G
----------
K
YD---------
L
-------
F
---
G
A
E
P
V
T
A
A
A
A
A
H
G
K
T
P
A
Q
A
V
L
R
W
H
L
Q
K
G
F
V
V
F
P
K
S
V
R
R
E
R
L
E
E
N
L
D
V
F
D
F
D
L
T
D
T
E
I
A
A
I
D
A
M
D
-
P
GDG
S
G
R
-----
V
S
A
H
P
D
E
V
D
-
31
PsiBlast_CBE
65.86
51%
-13
- C5 -
3O0K
3
?
C:
[31-283]
----------
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
-----
W
Q
I
S
-
N
---
D
E
---
A
V
-
S
A
V
S
E
A
L
K
A
-
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
----
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
--------------------
P
S
---------------
K
D
L
-------------
F
-------
M
---------------
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
----------
G
----------------------------------
L
-------
L
---
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-----------------------
32
PsiBlast_CBE
65.32
51%
-11
- C5 -
3O0K
4
?
B:
[31-283]
----------
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
-----
W
Q
I
S
-
N
---
D
E
---
A
V
-
S
A
V
S
E
A
L
K
A
-
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
----
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
--------------------
P
S
---------------
K
D
L
-------------
F
-------
M
---------------
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
----------
G
----------------------------------
L
-------
L
---
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-----------------------
70
PsiBlast_CBE
65.21
37%
-8
- C5 -
3UZY
3
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
92
PsiBlast_CBE
65.15
37%
-7
- C5 -
3COT
2
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
30
PsiBlast_CBE
65.15
51%
-4
- C5 -
3O0K
3
?
D:
[31-283]
----------
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
-----
W
Q
I
S
-
N
---
D
E
---
A
V
-
S
A
V
S
E
A
L
K
A
-
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
----
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
--------------------
P
S
---------------
K
DL-------------
F
-------
M
---------------
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
----------
G
----------------------
K
-----------
L
-------
L
---
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-----------------------
109
HHSearch
65.14
51%
-9
- C5 -
3O0K
4
?
A:
[26-282]
-----
V
P
T
V
K
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
-----
W
Q
I
S
-
N
---
D
E
---
A
V
-
S
A
V
S
E
A
L
K
A
-
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
----
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
--------------------
P
S
K
D
-------------
L
---------------
F
-------
M
---------------
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------------------
L
-------
L
---
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
------------------------
75
PsiBlast_CBE
64.97
37%
-7
- C5 -
3UZW
2
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
AFKPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
88
PsiBlast_CBE
64.92
37%
-3
- C5 -
3G1R
2
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
68
PsiBlast_CBE
64.90
37%
-7
- C5 -
3UZZ
2
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
87
PsiBlast_CBE
64.87
37%
-1
- C5 -
3BUR
10
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
72
PsiBlast_CBE
64.76
37%
-6
- C5 -
3UZX
5
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
90
PsiBlast_CBE
64.70
37%
-4
- C5 -
3DOP
2
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
74
PsiBlast_CBE
64.70
37%
-5
- C5 -
3UZW
3
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
94
PsiBlast_CBE
64.58
37%
-7
- C5 -
3CMF
2
AK1D1_HUMAN
B:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
84
PsiBlast_CBE
64.57
37%
0
- C5 -
3BUV
3
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
73
PsiBlast_CBE
64.32
37%
-6
- C5 -
3UZX
3
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
69
PsiBlast_CBE
64.28
37%
-5
- C5 -
3UZZ
3
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
82
PsiBlast_CBE
64.21
37%
-4
- C5 -
3BV7
2
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
86
PsiBlast_CBE
64.08
37%
-4
- C5 -
3BUR
7
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
71
PsiBlast_CBE
64.04
37%
-5
- C5 -
3UZY
3
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
H
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
77
PsiBlast_CBE
63.98
37%
-4
- C5 -
3CAV
6
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
91
PsiBlast_CBE
63.97
37%
-4
- C5 -
3DOP
1
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
41
PsiBlast_CBE
63.95
41%
2
- C5 -
3WBY
1
?
B:
[14-282]
-----
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
-----
W
E
T
P
-
P
---
D
E
---
T
A
-
E
V
V
K
E
A
V
K
L
-
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
E
---------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
PA------------------
Q
G
---------------
Q
---------------
Y
-------
V
---------------
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
----
L
----------
G
K
----------
G
----------
R
-----------
V
-------
L
---
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
---
D
G
R
-----
M
G
A
D
P
N
T
A
K
F
80
PsiBlast_CBE
63.90
37%
-5
- C5 -
3CAQ
5
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
83
PsiBlast_CBE
63.87
37%
-3
- C5 -
3BV7
4
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
62
PsiBlast_CBE
63.78
37%
-35
- C5 -
3H7R
13
AKRC8_ARATH
A:
[30-293]
----------
L
N
T
G
A
K
L
P
C
V
G
L
G
T
-----
Y
A
M
-----------
V
A
-
T
A
I
E
Q
A
I
K
I
-
G
Y
R
H
I
D
C
A
S
I
Y
G
N
E
K
E
I
G
G
V
L
K
K
L
I
G
D
G
-
F
V
K
R
E
E
L
F
I
T
S
K
L
W
S
N
D
H
L
P
E
D
V
P
K
A
L
E
K
T
L
Q
D
L
Q
I
D
Y
V
D
L
Y
L
I
H
W
P
------------------
A
--------------------
S
L
---------------
K
---------------
K
-------
E
SLMPTPEMLTKPD
I
T
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
S
K
K
L
T
D
L
L
N
V
A
--
R
V
T
--
P
A
V
N
Q
V
E
C
H
P
V
W
Q
Q
Q
G
L
H
E
L
C
K
S
K
G
V
H
L
S
G
Y
S
P
----
L
GSQSKGE---
V
R
----------
L
----------
K
-----------
V
-------
L
---
Q
N
P
I
V
T
E
V
A
E
K
L
G
K
T
T
A
Q
V
A
L
R
W
G
L
Q
T
G
H
S
V
L
P
K
S
S
S
G
A
R
L
K
E
N
L
D
V
F
D
W
S
I
P
E
D
--------------------------------
89
PsiBlast_CBE
63.76
37%
-1
- C5 -
3G1R
1
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
76
PsiBlast_CBE
63.64
37%
-4
- C5 -
3CAV
5
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
93
PsiBlast_CBE
63.60
37%
-1
- C5 -
3COT
2
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
10
PsiBlast_PDB
63.55
51%
-7
- C5 -
3O0K
4
?
A:
[31-283]
----------
L
N
D
G
N
H
I
P
Q
L
G
Y
G
V
-----
W
Q
I
S
-
N
---
D
E
---
A
V
-
S
A
V
S
E
A
L
K
A
-
G
Y
R
H
I
D
T
A
T
I
Y
G
N
E
E
G
V
G
K
A
I
N
G
----
S
-
G
I
A
R
A
D
I
F
L
T
T
K
L
W
N
S
D
Q
G
Y
E
S
T
L
K
A
F
D
T
S
L
K
K
L
G
T
D
Y
V
D
L
Y
L
I
H
W
P
------------------
M
--------------------
P
S
---------------
K
D
L
-------------
F
-------
M
---------------
E
--------------------
T
W
R
A
F
I
K
L
K
E
E
G
R
V
K
S
I
G
V
S
N
F
R
T
A
D
L
E
R
L
I
K
E
S
--
G
V
T
--
P
V
L
N
Q
I
E
L
H
P
Q
F
Q
Q
D
E
L
R
L
F
H
G
K
H
D
I
A
T
E
A
W
S
P
----
L
----------
G
Q
----------
G
----------------------
L
-------
L
---
E
D
P
T
L
K
S
I
A
E
K
H
A
K
S
V
A
Q
I
I
L
R
W
H
I
E
T
G
N
I
V
I
P
K
S
I
T
P
A
R
I
K
E
N
F
D
I
F
D
F
T
L
N
G
T
D
H
D
A
I
T
K
L
D
-----------------------
95
PsiBlast_CBE
63.52
37%
-3
- C5 -
3CMF
2
AK1D1_HUMAN
A:
[29-327]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
40
PsiBlast_CBE
63.38
42%
7
- C5 -
3WBW
3
?
B:
[14-282]
-----
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
-----
W
E
T
P
-
P
---
D
E
---
T
A
-
E
V
V
K
E
A
V
K
L
-
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
E
---------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
PA------------------
Q
G
---------------
Q
---------------
Y
-------
V
---------------
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
----
L
----------
G
K
----------
G
----------
R
-----------
V
-------
L
---
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
---
D
G
R
-----
M
G
A
D
P
N
T
A
K
F
78
PsiBlast_CBE
63.35
37%
1
- C5 -
3CAS
5
AK1D1_HUMAN
B:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KGA
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
AFKPGDEIYPRDE-------
N
G
---------------
K
---------------
W
LYHKSNL
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
79
PsiBlast_CBE
63.26
37%
-1
- C5 -
3CAS
6
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
81
PsiBlast_CBE
63.24
37%
-1
- C5 -
3CAQ
5
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
L
Y
H
KSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
19
PsiBlast_PDB
63.09
42%
12
- C5 -
3WBW
2
?
A:
[14-282]
-----
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
-----
W
E
T
P
-
P
---
D
E
---
T
A
-
E
V
V
K
E
A
V
K
L
-
G
Y
R
S
V
D
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
E
---------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
PA------------------
Q
G
---------------
Q
---------------
Y
-------
V
---------------
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
----
L
----------
G
K
----------
G
----------
R
-----------
V
-------
L
---
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
---
D
G
R
-----
M
G
A
D
P
N
T
A
K
F
42
PsiBlast_CBE
62.92
41%
5
- C5 -
3WBY
2
?
A:
[14-282]
-----
Q
T
V
I
S
F
H
D
G
H
T
M
P
Q
I
G
L
G
V
-----
W
E
T
P
-
P
---
D
E
---
T
A
-
E
V
V
K
E
A
V
K
L
-
G
Y
R
S
V
A
T
A
R
L
Y
K
N
E
E
G
V
G
K
G
L
E
D
H
P
E
---------
I
F
L
T
T
K
L
W
N
D
E
Q
G
Y
D
S
T
L
R
A
Y
E
E
S
A
R
L
L
R
R
P
V
L
D
L
Y
L
I
H
W
P
------------------
M
PA------------------
Q
G
---------------
Q
---------------
Y
-------
V
---------------
E
--------------------
T
W
K
A
L
V
E
L
K
K
S
G
R
V
K
S
I
G
V
S
N
F
E
S
E
H
L
E
R
I
M
D
A
T
--
G
V
V
--
P
V
V
N
Q
I
E
L
H
P
D
F
Q
Q
R
A
L
R
E
F
H
E
K
H
N
I
R
T
E
S
W
R
P
----
L
----------
G
K
----------
G
----------
R
-----------
V
-------
L
---
S
D
E
R
I
G
K
I
A
E
K
H
S
R
T
P
A
Q
V
V
I
R
W
H
L
Q
N
G
L
I
V
I
P
K
S
V
N
P
K
R
L
A
E
N
L
D
V
F
G
F
V
L
D
A
D
D
M
Q
A
I
E
Q
M
D
R
K
---
D
G
R
-----
M
G
A
D
P
N
T
A
K
F
85
PsiBlast_CBE
62.78
37%
-1
- C5 -
3BUV
4
AK1D1_HUMAN
A:
[9-307]
-------
R
I
P
L
S
D
G
N
S
I
P
I
I
G
L
G
T
-----
Y
S
E
P
-
K
--
S
T
P
KG
A
C
A
-
T
S
V
K
V
A
I
D
T
-
G
Y
R
H
I
D
G
A
Y
I
Y
Q
N
E
H
E
V
G
E
A
I
R
E
K
I
A
E
G
-
K
V
R
R
E
D
I
F
Y
C
G
K
L
W
A
T
N
H
V
P
E
M
V
R
P
T
L
E
R
T
L
R
V
L
Q
L
D
Y
V
D
L
Y
I
I
E
V
P
------------------
M
A
F
KPGDEI
Y
P
R
D
E-------
N
G
---------------
K
---------------
W
LYHKSN
L
C
---------------
A
--------------------
T
W
E
A
M
E
A
C
K
D
A
G
L
V
K
S
L
G
V
S
N
F
N
R
R
Q
L
E
L
I
L
N
K
P
--
G
L
K
HK
P
V
S
N
Q
V
E
C
H
P
Y
F
T
Q
P
K
L
L
K
F
C
Q
Q
H
D
I
V
I
T
A
Y
S
P
----
L
----------
G
T
----------
S
----------
R
NPIWVNVSSPP
L
-------
L
---
K
D
A
L
L
N
S
L
G
K
R
Y
N
K
T
A
A
Q
I
V
L
R
F
N
I
Q
R
G
V
V
V
I
P
K
S
F
N
L
E
R
I
K
E
N
F
Q
I
F
D
F
S
L
T
E
E
E
M
K
D
I
E
A
L
N
-
K
---
N
V
R
---------------
14
PsiBlast_PDB
62.04
41%
-
- C5 -
1AE4
1
AK1A1_PIG
A:
[8-297]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNPFPKN-----
A
--------------------
D
G
---------------
T
IRYDATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
13
PsiBlast_PDB
62.03
41%
-
- C5 -
1CWN
1
AK1A1_PIG
A:
[7-296]
----------
L
H
T
G
Q
K
M
P
L
I
G
L
G
T
-----
W
K
S
E
-
P
--
G
-
Q
---
V
K
-
A
A
I
K
Y
A
L
T
V
-
G
Y
R
H
I
D
C
A
A
I
Y
G
N
E
L
E
I
G
E
A
L
T
E
T
V
G
P
G
K
A
V
P
R
E
E
L
F
V
T
S
K
L
W
N
T
K
H
H
P
E
D
V
E
P
A
L
R
K
T
L
A
D
L
Q
L
E
Y
L
D
L
Y
L
M
H
W
P
Y
A
F
ERGDNP
F
P
K
N
-----
A
--------------------
D
G
---------------
T
I
R
Y
D
ATH--------
Y
-------
K
---------------
D
--------------------
T
W
K
A
L
E
A
L
V
A
K
G
L
V
R
A
L
G
L
S
N
F
S
S
R
Q
I
D
D
V
L
S
V
A
--
S
V
R
--
P
A
V
L
Q
V
E
C
H
P
Y
L
A
Q
N
E
L
I
A
H
C
Q
A
R
G
L
E
V
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
D
RAWRDPNEPV-
L
-------
L
---
E
E
P
V
V
Q
A
L
A
E
K
Y
N
R
S
P
A
Q
I
L
L
R
W
Q
V
Q
R
K
V
I
C
I
P
K
S
V
T
P
S
R
I
P
Q
N
I
Q
V
F
D
F
T
F
S
P
E
E
M
K
Q
L
D
A
L
N
-
K
---
N
L
R
---------------
56
PsiBlast_CBE
61.04
39%
2
- C5 -
3WCZ
6
AK2E4_BOMMO
A:
[10-294]
----------
L
N
D
G
N
T
I
P
I
V
A
L
G
T
GRGTA
K
E
S
D
-
S
--
I
D
E
---
V
R
-
Q
A
V
Y
W
A
I
E
A
-
G
Y
R
H
I
D
T
A
A
V
Y
Q
D
E
E
Q
V
G
Q
G
I
A
E
A
I
A
N
G
-
L
V
T
R
E
E
L
F
V
T
T
K
L
W
N
D
K
H
A
R
D
Q
V
V
P
A
L
Q
E
S
L
K
K
L
G
L
D
Y
I
D
L
Y
L
I
H
F
P
------------------
I
--------------------
A
T
---------------
K
PDDS
P
D
N
I
D------
Y
-------
L
---------------
E
--------------------
T
W
Q
G
M
Q
D
A
R
Q
L
G
L
A
R
S
I
G
V
S
N
F
N
A
T
Q
I
T
R
L
V
S
N
S
--
Y
I
R
--
P
V
I
N
Q
I
E
V
N
P
T
N
T
Q
E
P
L
V
A
H
C
Q
S
L
G
I
A
V
M
A
Y
S
P
FGFV
V
----------
S
R
----------
G
----------
Q
-----------
T
GAPPPR-
S
---
D
D
P
T
L
T
A
L
A
N
K
Y
R
K
S
V
G
Q
I
L
L
R
Y
L
I
D
R
G
L
I
P
I
P
K
S
T
N
K
Q
R
I
A
Q
N
I
D
L
F
D
F
Q
L
T
F
E
E
V
A
A
I
N
Q
F
N
-
K
---
N
H
R
-----
V
---------
57
PsiBlast_CBE
60.83
41%
-9
- C5 -
3H7U
2
AKRC9_ARATH
A:
[30-294]
----------
L
N
T
G
A
K
F
P
S
V
G
L
G
T
-----
W
Q
A
S
-
P
--
G
-----
L
V
G
D
A
V
A
A
A
V
K
I
-
G
Y
R
H
I
D
C
A
Q
I
Y
G
N
E
K
E
I
G
A
V
L
K
K
L
F
E
D
R
-
V
V
K
R
E
D
L
F
I
T
S
K
L
W
C
T
D
H
D
P
Q
D
V
P
E
A
L
N
R
T
L
K
D
L
Q
L
E
Y
V
D
L
Y
L
I
H
W
P
------------------
A
--------------------
R
I
---------------
K
K
GSVGIKPENLLPVD
I
-------
P
---------------
S
--------------------
T
W
K
A
M
E
A
L
Y
D
S
G
K
A
R
A
I
G
V
S
N
F
S
T
K
K
L
A
D
L
L
E
L
A
--
R
V
P
--
P
A
V
N
Q
V
E
C
H
P
S
W
R
Q
T
K
L
Q
E
F
C
K
S
K
G
V
H
L
S
A
Y
S
P
----
L
GSPGTTW---
L
K
----------
S
----------
D
-----------
V
-------
L
---
K
N
P
I
L
N
M
V
A
E
K
L
G
K
S
P
A
Q
V
A
L
R
W
G
L
Q
M
G
H
S
V
L
P
K
S
T
N
E
G
R
I
K
E
N
F
N
V
F
D
W
S
I
-----------------------------------
59
PsiBlast_CBE
60.18
38%
9
- C5 -
2BGS
4
ALDR_HORVU
A:
[42-318]
----------
L
K
S
G
H
A
M
P
A
V
G
L
G
T
-----
W
R
A
-----
G
S
D
---
T
A
-
H
S
V
R
T
A
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
V
E
K
E
V
G
K
G
L
K
A
A
M
E
-
A
-
G
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
F
R
L
K
DGAHMPPEAGE
V
--
L
--------------------
E
F
---------------
D
---------------
M
-------
E
---------------
G
--------------------
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
S
A
--
K
I
P
--
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
E
KN---------
L
-------
A
---
H
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
F
G
W
E
I
P
E
E
D
F
K
V
L
C
S
I
K
-
D
---
E
K
R
-----
V
---------
58
PsiBlast_CBE
59.39
38%
6
- C5 -
2VDG
6
ALDR_HORVU
A:
[42-318]
----------
L
K
S
G
H
A
M
P
A
V
G
L
G
T
-----
W
R
A
-----
G
S
D
---
T
A
-
H
S
V
R
T
A
I
T
E
A
G
Y
R
H
V
D
T
A
A
E
Y
G
V
E
K
E
V
G
K
G
L
K
A
A
M
E
-
A
-
G
I
D
R
K
D
L
F
V
T
S
K
I
W
C
T
N
L
A
P
E
R
V
R
P
A
L
E
N
T
L
K
D
L
Q
L
D
Y
I
D
L
Y
H
I
H
W
P
F
R
L
K
DGAHMPPEAGE
V
--
L
--------------------
E
F
---------------
D
---------------
M
-------
E
---------------
G
--------------------
V
W
K
E
M
E
N
L
V
K
D
G
L
V
K
D
I
G
V
C
N
Y
T
V
T
K
L
N
R
L
L
R
S
A
--
K
I
P
--
P
A
V
C
Q
M
E
M
H
P
G
W
K
N
D
K
I
F
E
A
C
K
K
H
G
I
H
I
T
A
Y
S
P
----
L
----------
G
S
----------
S
----------
E
KN---------
L
-------
A
---
H
D
P
V
V
E
K
V
A
N
K
L
N
K
T
P
G
Q
V
L
I
K
W
A
L
Q
R
G
T
S
V
I
P
K
S
S
K
D
E
R
I
K
E
N
I
Q
V
F
G
W
E
I
P
E
E
D
F
K
V
L
C
S
I
K
-
D
---
E
K
R
-----
V
---------
100
PsiBlast_CBE
58.91
36%
27
- C5 -
3NTY
3
AK1C1_HUMAN
A:
[10-319]
----------
L
N
D
G
H
F
M
P
V
L
G
F
G
T
-----
Y
A
P
A
-
E
VP
K
S
K
---
A
L
-
E
A
T
K
L
A
I
E
A
-
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
--------------------
S
V
---------------
K
---------------
P
-------
G
---------------
E
EV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
----
L
----------
G
S
----------
H
----------
R
EEPWVDPNSPV
L
-------
L
---
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
---
N
V
R
YLTLD
I
F
A
G
P
P
N
Y
P
F
98
PsiBlast_CBE
58.84
36%
31
- C5 -
4YVP
2
AK1C1_HUMAN
B:
[10-319]
----------
L
N
D
G
H
F
M
P
V
L
G
F
G
T
-----
Y
A
P
A
-
E
VP
K
S
K
---
A
L
-
E
A
T
K
L
A
I
E
A
-
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
--------------------
S
V
---------------
K
---------------
P
-------
G
---------------
E
EVIPKDENGKILFDTVDLCA
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
----
L
----------
G
S
----------
H
----------
R
EEPWVDPNSPV
L
-------
L
---
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
---
N
V
R
YLTLD
I
F
A
G
P
P
N
Y
P
F
99
PsiBlast_CBE
58.11
36%
32
- C5 -
4YVP
2
AK1C1_HUMAN
A:
[10-319]
----------
L
N
D
G
H
F
M
P
V
L
G
F
G
T
-----
Y
A
P
A
-
E
VP
K
S
K
---
A
L
-
E
A
T
K
L
A
I
E
A
-
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
--------------------
S
V
---------------
K
---------------
P
-------
G
---------------
E
EV
I
P
K
D
ENGKIL
F
D
T
V
D
L
C
A
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
----
L
----------
G
S
----------
H
----------
R
EEPWVDPNSPV
L
-------
L
---
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
---
N
V
R
YLTLD
I
F
A
G
P
P
N
Y
P
F
96
PsiBlast_CBE
58.11
36%
28
- C5 -
3GUG
3
AK1C1_HUMAN
A:
[10-319]
----------
L
N
D
G
H
F
M
P
V
L
G
F
G
T
-----
Y
A
P
A
-
E
VP
K
S
K
---
A
L
-
E
A
T
K
L
A
I
E
A
-
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
--------------------
S
V
---------------
K
---------------
P
-------
G
---------------
E
EV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
----
L
----------
G
S
----------
H
----------
R
EEPWVDPNSPV
L
-------
L
---
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
---
N
V
R
YLTVD
I
F
A
G
P
P
N
Y
P
F
97
PsiBlast_CBE
56.68
36%
29
- C5 -
1MRQ
3
AK1C1_HUMAN
A:
[10-319]
----------
L
N
D
G
H
F
M
P
V
L
G
F
G
T
-----
Y
A
P
A
-
E
VP
K
S
K
---
A
L
-
E
A
T
K
L
A
I
E
A
-
G
F
R
H
I
D
S
A
H
L
Y
N
N
E
E
Q
V
G
L
A
I
R
S
K
I
A
D
G
-
S
V
K
R
E
D
I
F
Y
T
S
K
L
W
C
N
S
H
R
P
E
L
V
R
P
A
L
E
R
S
L
K
N
L
Q
L
D
Y
V
D
L
Y
L
I
H
F
P
------------------
V
--------------------
S
V
---------------
K
---------------
P
-------
G
---------------
E
EV
I
P
K
D
ENG
K
I
L
F
D
T
V
D
L
C
A
T
W
E
A
V
E
K
C
K
D
A
G
L
A
K
S
I
G
V
S
N
F
N
R
R
Q
L
E
M
I
L
N
K
P
GL
K
Y
K
--
P
V
C
N
Q
V
E
C
H
P
Y
F
N
Q
R
K
L
L
D
F
C
K
S
K
D
I
V
L
V
A
Y
S
A
----
L
----------
G
S
----------
H
----------
R
EEPWVDPNSPV
L
-------
L
---
E
D
P
V
L
C
A
L
A
K
K
H
K
R
T
P
A
L
I
A
L
R
Y
Q
L
Q
R
G
V
V
V
L
A
K
S
Y
N
E
Q
R
I
R
Q
N
V
Q
V
F
E
F
Q
L
T
S
E
E
M
K
A
I
D
G
L
N
-
R
---
N
V
R
YLTLD
I
F
A
G
P
P
N
Y
P
F
64
PsiBlast_CBE
45.66
41%
1
- C5 -
1AH0
2
ALDR_PIG
A:
[8-298]
---------
V
L
Y
T
G
A
K
M
P
I
L
G
L
G
T
-----
W
K
S
P
-
P
--
G
-
K
---
V
T
-
E
A
V
K
V
A
I
D
L
-
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
L
G
L
Q
E
K
L
Q
G
Q
-
V
V
K
R
E
D
L
F
I
V
S
K
L
W
C
T
D
H
E
K
N
L
V
K
G
A
C
Q
T
T
L
R
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
T
G
F
KPGKDPFPLDGDG
N
V
V
P
D
E
S
---------------
D
---------------
F
-------
V
---------------
E
--------------------
T
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
V
S
N
F
N
H
L
Q
V
E
K
I
L
N
K
P
GL
K
Y
K
--
P
A
V
N
Q
I
E
V
H
P
Y
L
T
Q
E
K
L
I
E
Y
C
K
S
K
G
I
V
V
T
A
Y
S
P
----
L
----------
G
S
PDRPWAKPED
P
----------
S
-----------
L
-------
L
---
E
D
P
R
I
K
A
I
A
A
K
Y
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
I
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
Q
V
F
D
F
E
L
S
P
E
D
M
N
T
L
L
S
Y
N
-
R
---
N
W
R
-----
V
---------
67
PsiBlast_CBE
44.78
41%
3
- C5 -
1AH3
2
ALDR_PIG
A:
[7-297]
---------
V
L
Y
T
G
A
K
M
P
I
L
G
L
G
T
-----
W
K
S
P
-
P
--
G
-
K
---
V
T
-
E
A
V
K
V
A
I
D
L
-
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
L
G
L
Q
E
K
L
Q
G
Q
-
V
V
K
R
E
D
L
F
I
V
S
K
L
W
C
T
D
H
E
K
N
L
V
K
G
A
C
Q
T
T
L
R
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
T
G
F
KPGKDP
F
P
L
D
GDG
N
V
V
P
D
E
S
---------------
D
---------------
F
-------
V
---------------
E
--------------------
T
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
V
S
N
F
N
H
L
Q
V
E
K
I
L
N
K
P
GL
K
Y
K
--
P
A
V
N
Q
I
E
V
H
P
Y
L
T
Q
E
K
L
I
E
Y
C
K
S
K
G
I
V
V
T
A
Y
S
P
----
L
----------
G
S
PDRPWAKPED
P
----------
S
-----------
L
-------
L
---
E
D
P
R
I
K
A
I
A
A
K
Y
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
I
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
Q
V
F
D
F
E
L
S
P
E
D
M
N
T
L
L
S
Y
N
-
R
---
N
W
R
-----
V
---------
66
PsiBlast_CBE
44.20
41%
0
- C5 -
1AH4
1
ALDR_PIG
A:
[7-297]
---------
V
L
Y
T
G
A
K
M
P
I
L
G
L
G
T
-----
W
K
S
P
-
P
--
G
-
K
---
V
T
-
E
A
V
K
V
A
I
D
L
-
G
Y
R
H
I
D
C
A
H
V
Y
Q
N
E
N
E
V
G
L
G
L
Q
E
K
L
Q
G
Q
-
V
V
K
R
E
D
L
F
I
V
S
K
L
W
C
T
D
H
E
K
N
L
V
K
G
A
C
Q
T
T
L
R
D
L
K
L
D
Y
L
D
L
Y
L
I
H
W
P
------------------
T
G
F
KPGKDP
F
P
L
D
GDG
N
V
V
P
D
E
S
---------------
D
---------------
F
-------
V
---------------
E
--------------------
T
W
E
A
M
E
E
L
V
D
E
G
L
V
K
A
I
G
V
S
N
F
N
H
L
Q
V
E
K
I
L
N
K
P
GL
K
Y
K
--
P
A
V
N
Q
I
E
V
H
P
Y
L
T
Q
E
K
L
I
E
Y
C
K
S
K
G
I
V
V
T
A
Y
S
P
----
L
----------
G
S
PDRPWAKPED
P
----------
S
-----------
L
-------
L
---
E
D
P
R
I
K
A
I
A
A
K
Y
N
K
T
T
A
Q
V
L
I
R
F
P
M
Q
R
N
L
I
V
I
P
K
S
V
T
P
E
R
I
A
E
N
F
Q
V
F
D
F
E
L
S
P
E
D
M
N
T
L
L
S
Y
N
-
R
---
N
W
R
-----
V
---------