@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF02146_HST2_Y: (2014-09-28 )
MSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNLETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQGGMGDNSKEQLLEIVHDLENLSLDQSEHESADKKDKKLQRLNGHDSDEDGASNSSSSQKAAKE
Atome Classification :
(25 SA)
.........10........20........30........40........50........60........70........80......--..90........100.......110.......120.......130.......140...--....150.......160.......------------------------170.......180.......190.......200.......210.......220.......230.......-240.......250..----------------.....260.......270.--......280.......290.......300.......310.......320.......330.......340.......350.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSVSTA
S
T
E
M
S
V
R
K
I
A
A
H
MKSNPN
A
K
V
I
F
M
VGAGISTSCGIPDFRSPG
T
G
L
Y
H
N
L
A
R
LKLPYPE
A
V
F
D
V
DFFQSDP
L
P
F
Y
T
L
A
K
E
LY--PGNFR
P
S
K
F
H
Y
L
L
K
L
FQ
D
K
D
V
L
K
R
V
Y
TQ
N
I
D
T
L
E
R
QAGVKD
D
L
I
I
E
AHGS
F
A
H
C
H
C
IG--CGKVY
P
P
Q
V
F
K
S
K
L
A
EH
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
FGEDL
P
D
S
F
S
E
TWL
N
D
S
E
W
L
R
E
K
ITTSGKHPQQ
P
L
V
I
V
VGTS
L
A
VY
P
F
AS
L
P
E
E
I
P
-
R
K
V
K
R
V
L
CNLETVGD----------------FKANKRPT
D
L
I
V
HQY
S
D
E
F
--
A
E
Q
L
V
E
ELG
W
Q
E
D
F
E
K
I
L
T
AQGGMGDN
S
K
E
Q
L
L
E
I
V
H
D
L
E
NLSLD
Q
S
EHESA
D
K
K
D
K
K
L
Q
RLNGHDSDEDGASNSSSSQKAAKE
5
PsiBlast_PDB
96.67
100%
-117
- C3 -
2OD7
2
HST2_YEAST
A:
[15-307]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
-------
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
8
PsiBlast_PDB
96.00
100%
-112
- C3 -
2QQG
3
HST2_YEAST
A:
[15-307]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
-----
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
6
PsiBlast_PDB
96.00
100%
-112
- C3 -
2OD9
3
HST2_YEAST
A:
[15-307]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
-----
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
3
PsiBlast_PDB
95.98
100%
-111
- C3 -
1SZD
5
HST2_YEAST
A:
[4-296]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
-----
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
10
PsiBlast_PDB
95.92
100%
-118
- C3 -
1Q1A
2
HST2_YEAST
A:
[1-289]
----
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
----
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
4
PsiBlast_PDB
95.89
100%
-114
- C3 -
1Q17
2
HST2_YEAST
A:
[7-300]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
--------
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
Q
---------------------------------------------------------------
2
PsiBlast_PDB
95.49
100%
-112
- C3 -
1SZC
6
HST2_YEAST
A:
[4-296]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
-----
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
21
PsiBlast_CBE
95.42
100%
-117
- C3 -
1Q17
1
HST2_YEAST
C:
[7-300]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
----
K
H
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
Q
---------------------------------------------------------------
9
PsiBlast_PDB
95.41
99%
-114
- C3 -
2OD2
6
HST2_YEAST
A:
[15-307]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
F
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
T
T
-----
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
22
PsiBlast_CBE
95.27
100%
-109
- C3 -
1Q17
1
HST2_YEAST
B:
[7-300]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
------
P
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
Q
---------------------------------------------------------------
7
PsiBlast_PDB
95.20
100%
-115
- C3 -
2QQF
2
HST2_YEAST
A:
[15-307]
M
S
V
S
T
A
S
T
E
M
S
V
R
K
I
A
A
H
M
K
S
N
P
N
A
K
V
I
F
M
V
G
A
G
I
S
T
S
C
G
I
P
D
F
R
S
P
G
T
G
L
Y
H
N
L
A
R
L
K
L
P
Y
P
E
A
V
F
D
V
D
F
F
Q
S
D
P
L
P
F
Y
T
L
A
K
E
L
Y
--
P
G
N
F
R
P
S
K
F
H
Y
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
T
Q
N
I
D
T
L
E
R
Q
A
G
V
K
D
D
L
I
I
E
A
H
G
S
F
A
H
C
H
C
I
G
--
C
G
K
V
Y
P
P
Q
V
F
K
S
K
L
A
E
H
P
I
K
D
F
V
K
------------------------
C
D
V
C
G
E
L
V
K
P
A
I
V
F
F
G
E
D
L
P
D
S
F
S
E
T
W
L
N
D
S
E
W
L
R
E
K
I
-------
Q
Q
P
L
V
I
V
V
G
T
S
L
A
V
Y
P
F
A
S
L
P
E
E
I
P
-
R
K
V
K
R
V
L
C
N
L
E
T
V
G
D
----------------
F
K
A
N
K
R
P
T
D
L
I
V
H
Q
Y
S
D
E
F
--
A
E
Q
L
V
E
E
L
G
W
Q
E
D
F
E
K
I
L
T
A
----------------------------------------------------------------
33
HHSearch
79.70
44%
-99
- C3 -
3ZGO
3
SIR2_HUMAN
A:
[24-321]
--
K
E
R
L
L
D
E
L
T
L
E
G
V
A
R
Y
M
Q
S
E
R
C
R
R
V
I
C
L
V
G
A
G
I
S
T
S
A
G
I
P
D
F
R
S
P
S
T
G
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Y
F
K
K
H
P
E
P
F
F
A
L
A
K
E
L
Y
--
P
G
Q
F
K
P
T
I
C
H
Y
F
M
R
L
L
K
D
K
G
L
L
L
R
C
Y
T
Q
N
I
D
T
L
E
R
I
A
G
L
E
Q
E
D
L
V
E
A
H
G
T
F
Y
T
S
H
C
V
S
AS
C
R
H
E
Y
P
L
S
W
M
K
E
K
I
F
S
E
V
T
P
---
K
------------------------
C
E
D
C
Q
S
L
V
K
P
D
I
V
F
F
G
E
S
P
P
A
R
F
F
S
C
M
Q
S
D
F
-------------
L
K
V
D
L
L
L
V
M
G
T
S
L
Q
V
Q
P
F
A
S
L
I
S
K
A
P
-
L
S
T
P
R
L
L
I
N
K
E
K
A
G
Q
SD
P
F
L
G
M
I
M
G
L
G
GGMD
F
D
S
K
K
A
Y
R
D
V
A
W
L
G
E
C
D
Q
G
--
C
L
A
L
A
E
L
L
G
W
K
K
E
L
E
D
L
V
R
R
E
H
A
S
I
-----------------------------------------------------------
13
PsiBlast_PDB
74.31
41%
-99
- C3 -
4BVB
2
SIR3_HUMAN
A:
[7-279]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-----------------------------------------------------------
14
PsiBlast_PDB
74.28
41%
-102
- C3 -
4BVE
3
SIR3_HUMAN
A:
[6-279]
-------
G
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-----------------------------------------------------------
17
PsiBlast_PDB
73.98
41%
-92
- C3 -
4BVH
2
SIR3_HUMAN
A:
[6-277]
-------
G
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
-------------------------------------------------------------
15
PsiBlast_PDB
73.39
41%
-95
- C3 -
4BVF
2
SIR3_HUMAN
A:
[7-279]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-----------------------------------------------------------
16
PsiBlast_PDB
73.21
41%
-95
- C3 -
4BVG
13
SIR3_HUMAN
A:
[7-279]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-----------------------------------------------------------
19
PsiBlast_PDB
71.92
41%
-95
- C3 -
4C7B
6
SIR3_HUMAN
A:
[6-277]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
-----------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
------------------------------------------------------------
12
PsiBlast_PDB
71.89
41%
-97
- C3 -
4BV3
4
SIR3_HUMAN
A:
[7-276]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
P
G
S
G
L
Y
S
N
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
--------------------------------------------------------------
11
PsiBlast_PDB
71.73
41%
-97
- C3 -
4HD8
3
SIR3_HUMAN
A:
[7-278]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
------------
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
------------------------------------------------------------
18
PsiBlast_PDB
71.30
41%
-96
- C3 -
4C78
2
SIR3_HUMAN
A:
[7-279]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
R
S
------------
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
G
K
L
-----------------------------------------------------------
20
PsiBlast_PDB
70.56
42%
-97
- C3 -
4FZ3
1
SIR3_HUMAN
A:
[6-275]
--------
K
L
S
L
Q
D
V
A
E
L
I
R
A
R
A
C
Q
R
V
V
V
M
V
G
A
G
I
S
T
P
S
G
I
P
D
F
----------
L
Q
Q
Y
D
L
P
Y
P
E
A
I
F
E
L
P
F
F
F
H
N
P
K
P
F
F
T
L
A
K
E
L
Y
--
P
G
N
Y
K
P
N
V
T
H
Y
F
L
R
L
L
H
D
K
G
L
L
L
R
L
Y
T
Q
N
I
D
G
L
E
R
V
S
G
I
P
A
S
K
L
V
E
A
H
G
T
F
A
S
A
T
C
T
V
--
C
Q
R
P
F
P
G
E
D
I
R
A
D
V
M
A
D
R
V
P
---
R
------------------------
C
P
V
C
T
G
V
V
K
P
D
I
V
F
F
G
E
P
L
P
Q
R
F
--------------
L
L
H
V
V
D
F
P
M
A
D
L
L
L
I
L
G
T
S
L
E
V
E
P
F
A
S
L
T
E
A
V
R
-
S
S
V
P
R
L
L
I
N
R
D
L
V
G
P
----------------
L
A
W
H
P
R
S
R
D
--
V
A
Q
L
G
D
V
V
H
G
V
E
S
L
V
E
L
L
G
W
T
E
E
M
R
D
L
V
Q
R
E
T
--------------------------------------------------------------
38
HHSearch
70.20
33%
-105
- C3 -
4IAO
1
SIR2_YEAST
A:
[171-465]
--------
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
E
-
G
F
Y
S
K
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
PEGYNNKSMSERPPY
I
L
N
S
Y
G
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
I
-------------
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
----------------
A
-----
E
F
D
L
S
L
L
G
Y
C
D
D
I
--
A
A
M
V
A
Q
K
C
G
W
T
I
P
H
-
K
K
W
N
D
----------------------------------------------------------------
37
HHSearch
69.25
33%
-104
- C3 -
2HJH
2
SIR2_YEAST
A:
[30-327]
-----
L
S
N
F
F
T
I
D
H
F
I
Q
K
L
H
T
--
A
R
K
I
L
V
L
T
G
A
G
V
S
T
S
L
G
I
P
D
F
R
S
S
E
-
G
F
Y
S
K
I
K
H
L
G
L
D
D
P
Q
D
V
F
N
Y
N
I
F
M
H
D
P
S
V
F
Y
N
I
A
N
M
V
L
--
P
P
E
K
I
Y
S
P
L
H
S
F
I
K
M
L
Q
M
K
G
K
L
L
R
N
Y
T
Q
N
I
D
N
L
E
S
Y
A
G
I
S
T
D
K
L
V
Q
C
H
G
S
F
A
T
A
T
C
V
T
--
C
H
W
N
L
P
G
E
R
I
F
N
K
I
R
N
L
E
L
P
L
C
P
Y
C
Y
K
K
R
R
E
Y
F
PERPPY---------
I
L
N
S
Y
G
V
L
K
P
D
I
T
F
F
G
E
A
L
P
N
K
F
H
K
S
I
R
E
D
I
-------------
L
E
C
D
L
L
I
C
I
G
T
S
L
K
V
A
P
V
S
E
I
V
N
M
V
P
-
S
H
V
P
Q
V
L
I
N
R
D
P
V
K
H
----------------
A
-----
E
F
D
L
S
L
L
G
Y
C
D
D
I
--
A
A
M
V
A
Q
K
C
G
W
T
I
P
H
-
K
K
W
N
D
----------------------------------------------------------------
40
HHSearch
63.52
36%
-100
- C3 -
1YC5
2
NPD_THEMA
A:
[2-245]
----------
K
M
K
E
F
L
D
L
L
N
E
--
S
R
L
T
V
T
L
T
G
A
G
I
S
T
P
S
G
I
P
D
F
-------------------
Q
N
V
F
D
I
D
F
F
Y
S
H
P
E
E
F
Y
R
F
A
K
E
G
I
FP
M
L
Q
A
K
P
N
L
A
H
V
L
L
A
K
L
E
E
K
G
L
I
E
A
V
I
T
Q
N
I
D
R
L
H
Q
R
A
G
--
S
K
K
V
I
E
L
H
G
N
V
E
E
Y
Y
C
V
R
--
C
E
K
K
Y
T
V
E
D
V
I
K
K
L
E
S
S
D
V
P
---
L
------------------------
C
D
D
C
N
S
L
I
R
P
N
I
V
F
F
G
E
N
L
P
Q
D
A
L
R
E
A
I
G
L
-------------
S
S
R
A
S
L
M
I
V
L
G
S
S
L
V
V
Y
P
A
A
E
L
P
L
I
T
V
R
S
G
G
K
L
V
I
V
N
L
G
E
T
P
F
--------------------
D
D
I
A
T
L
K
Y
N
M
D
V
V
E
F
--
A
R
R
V
M
E
E
G
G
I
--------------------------------------------------------------------------